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10,011,603 | Citrate synthesis in intact rat-liver mitochondria is irreversible. | [
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10,011,604 | Rat-liver mitochondria were incubated with [1,5-14C]citrate in the presence of fluorocitrate to block its oxidation in the Krebs cycle. The reaction products were analysed enzymatically and by anion-exchange chromatography. Incorporation of 14C into acetyl-L-carnitine or ketone bodies via a backward action of citrate s... | [
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10,011,605 | Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets. | [
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10,011,606 | Ribosomal protein S6 from Xenopus laevis ovaries. Isolation, phosphorylation in vivo and cross-reaction with heterologous anti-S6 antibodies. | [
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10,011,607 | Ribosomal protein S6 from Xenopus laevis ovaries was prepared by ion-exchange chromatography on phosphocellulose and gel filtration on Sephadex G-75. The protein was identified as S6 from its position on two-dimensional polyacrylamide gels and from its immunological cross-reaction with monoclonal antibody raised agains... | [
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10,011,608 | 5,6-Dichlororibofuranosylbenzimidazole inhibits the rate of transcription initiation in intact Chironomus cells. | [
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10,011,609 | The 38,000-Mr poly(A)-binding protein of non-polysomal messenger ribonucleoproteins of cryptobiotic gastrulae of Artemia salina. | [
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10,011,610 | The 38,000-Mr poly(A)-binding protein has been purified to near homogeneity from non-polysomal messenger ribonucleoprotein of Artemia salina [Slegers, H., De Herdt, E., and Kondo, M. (1981) Eur. J. Biochem. 117, 111-120]. The protein consists of approximately 357 amino acids and is characterized by a high glycine conte... | [
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10,011,611 | Transport of the precursor for rat-liver ornithine carbamoyltransferase into mitochondria in vitro. | [
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10,011,612 | 'Artificial' myosin isozymes: preparation and characteristics. | [
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10,011,613 | Using precisely monitored proteolytic digestion conditions rabbit fast skeletal muscle myosin could be selectively modified in different ways. A myosin isozyme with a 20-kDa alkali light chain 1 (A1) could be obtained by digesting with papain in the presence of Ca2+. Under these conditions alkali light chain 2 (A2) was... | [
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10,011,614 | Local conformational transition of toxin B from Naja naja as studied by nuclear magnetic resonance and circular dichroism. | [
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10,011,615 | The 270-MHz proton NMR spectra of toxin B, a long neurotoxin from Naja naja, in 2H2O solution were analyzed. From the analysis of the discontinuous pH dependence of His-21 C-2 proton chemical shift a 23 degrees C, toxin B is found to exhibit a slow-exchange conformational transition between the states A and B with the ... | [
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10,011,616 | Pig heart [35S]thiophosphoryl pyruvate dehydrogenase complexes. | [
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10,011,617 | Thiophosphorylation of the pig heart pyruvate dehydrogenase complex with ATP [35S] (adenosine 5'[gamma-thio]-triphosphate) was analogous to phosphorylation with [gamma-32P]ATP except that thiophosphorylation of sites 2 and 3 was more rapid. With pyruvate dehydrogenase phosphatase the rate of dethiophosphorylation was 0... | [
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10,011,618 | Biosynthesis of vitamin B12 in anaerobic bacteria. Mode of incorporation of glycine into the 5,6-dimethylbenzimidazole moiety in Eubacterium limosum. | [
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10,011,619 | [1-13C]Glycine, [2-13C]glycine, and [15N]glycine were added to fermentations with the strictly anaerobic vitamin B12 producer Eubacterium limosum. The vitamin B12 isolated was almost exclusively labeled in its 5,6-dimethylbenzimidazole moiety. It was methylated and degraded to 1,5,6-trimethylbenzimidazole. The position... | [
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10,011,620 | Differential study of phosphatidylcholine and sphingomyelin in human high-density lipoproteins with lipid-specific fluorescent probes. | [
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10,011,621 | Modified phosphatidylcholine and sphingomyelin containing an anthryl end group attached to one of the fatty acyl chains were used as fluorescent probes in an investigation of the molecular organization of human high-density lipoproteins (HDL). Monolayer experiments and NMR measurements showed the anthryl-labeled lipids... | [
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10,011,622 | Role of sialic acid in the mobility of membrane proteins containing O-linked oligosaccharides on polyacrylamide gel electrophoresis in sodium dodecyl sulfate. | [
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10,011,623 | The major sialoglycoprotein of the human red-cell membrane, glycophorin A, contains 15 O-glycosidically linked oligosaccharides and one N-glycosidic oligosaccharide. The protein shows a decreased mobility on polyacrylamide gel electrophoresis in sodium dodecyl sulfate after neuraminidase treatment of the non-denatured ... | [
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10,011,624 | N-Glycosylation of proteins by homogenate preparations of developing chick embryos. | [
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10,011,625 | The isolation, from electromotor neurone perikarya, of messenger RNAs coding for synaptic proteins. | [
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10,011,626 | Poly(A)-containing mRNA was isolated from the electric lobe, cerebellum and forebrain of Torpedo marmorata and from cholinergic electromotor perikarya isolated from the electric lobe. All the mRNA preparations were translated by a cell-free protein-synthesizing system from rabbit reticulocytes; no brain-specific factor... | [
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10,011,627 | Asymmetric transbilayer distribution of sterol across plasma membranes determined by fluorescence quenching of dehydroergosterol. | [
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10,011,628 | A new method for measurement of transbilayer distribution of sterol in plasma membranes is reported. The procedure utilized a fluorescent sterol, dehydroergosterol, and a chemical quenching agent, trinitrobenzenesulfonic acid. Dehydroergosterol was useful as a probe molecule for sterols for the following reasons, (a) D... | [
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10,011,629 | Hepatobiliary scanning in cholecystitis. | [
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10,011,630 | To validate the use of 99mTc-PIPIDA in the diagnosis of biliary tract disease, 117 patients with clinical symptoms of acute cholecystitis were prospectively scanned as an initial screening test. The accuracy of the test was evaluated on the basis of surgical pathology in 59 patients. Three groups were defined: cystic d... | [
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10,011,631 | Bromide space, total body water, and sick cell syndrome. | [
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10,011,632 | Displacements of the bromide space (Br-82-C, as a marker for the extracellular fluid compartment) are caused by an enhanced anatomical space and/or increased permeability of cells to bromide. The ratio Br-82-C: total body water (TBW) was evaluated to be 0.83 +/- 0.17 in critically ill patients (n = 38) compared with th... | [
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10,011,633 | A scintillation camera technique for measurements of the reticuloendothelial function - comparison of different methods for measuring RES function. | [
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10,011,634 | A highly standardized 99mTc-sulphur colloid was used to evaluate reticuloendothelial system (RES)-function in the normal rat and after RE blockade by gelatin (Haemaccel). Activity distribution in the animals was measured with a scintillation camera technique. Total uptake of activity in the liver was estimated. From th... | [
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10,011,635 | Design and application of finite impulse response digital filters. | [
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10,011,636 | The finite impulse response (FIR) digital filter is a spatial domain filter with a frequency domain representation. The theory of the FIR filter is presented and techniques are described for designing FIR filters with known frequency response characteristics. Rational design principles are emphasized based on character... | [
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10,011,637 | Tc-generators - yield of 99mTc and ratio to 'inactive' 99Tc. | [
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10,011,638 | A large amount of inactive 99Tc in some delicate labeling techniques may adversely affect the results obtained. Therefore, it is important to know the ratio Q(t) of inactive 99Tc to active 99mTc, which is dependent on the time (t) elapsed since the last elution. On the other hand, in optimizing the use of Tc-generators... | [
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0.03625171259045601,
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0.10150706768035889,
0.07226... |
10,011,639 | Ischemia-induced transient left bundle branch block during exercise documented by 201Tl perfusion imaging. | [
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0.06075632944703102,
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0.01457... |
10,011,640 | The evolution of renal function after surgical treatment of malignant lithiasis with severely compromised renal function. | [
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... |
10,011,641 | 16 patients with calcic nephrolithiasis and renal failure were admitted to our institute and underwent surgery. 4 patients had bilateral nephrolithiasis and 12 cases had relapsed. Selective nephrotomy was performed in all cases, pyelotomy was done in 8 and partial nephrectomy in 2 patients. In 8 patients renal function... | [
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0.12624... |
10,011,642 | Vascular impressions on the renal-collecting system: diuretic cine-roentgenographic and angiographic study of 50 cases. | [
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10,011,643 | The vascular impressions on the renal pelvis and caliceal system may assume an important role in the study of some patients with hematuria and renal pain of unclear origin. 50 patients presenting vascular impressions on the calices and renal pelvis have been studied. In 12 patients (24%) the impressions were bilateral ... | [
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0.03... |
10,011,644 | Squamous metaplasia in cutaneous ureterostomy stomas. A reaction in everted ureteral mucosa. | [
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0.05192438140511513,
0.0001546648272778839,
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0.0... |
10,011,645 | Vesico-ureteric reflux in the neuropathic bladder with particular reference to the development of renal scarring. | [
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0.0954... |
10,011,646 | 96 unselected and consecutive patients with myeloceles (n = 75), meningomyeloceles (n = 17) and lipomatous meningomyeloceles (n = 4) were admitted to the Wessex Regional Paediatric Surgical Centre between 1st July, 1969, and 31st December, 1971, for early closure of the spinal defect. Intravenous pyelography and cystog... | [
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0.013628867454826832,
0.016312766820192337,
... |
10,011,647 | Effects of adrenergic drugs on miniature contractions of isolated dog urinary bladder. | [
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0.1... |
10,011,648 | Isolated dog urinary bladder showed spontaneous miniature contractions under a steady state. In dome preparations, norepinephrine and isoproterenol decreased the frequency of miniature contractions, while epinephrine produced biphasic responses on it; increase by low concentration and decrease by high concentrations. T... | [
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0.010141877457499504,
0.03734929859638214,
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0.0756... |
10,011,649 | Coexisting cyst of the utricle and carcinoma of the endometrial type in the prostate. | [
-0.027279524132609367,
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... |
10,011,650 | Retroperitoneal fibrosis in the scrotum. | [
-0.024321382865309715,
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0.08727920800447464,
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0.0... |
10,011,651 | A gigantic retroperitoneal myxoid liposarcoma. | [
-0.029833288863301277,
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0.05721193924546242,
0.0078875... |
10,011,652 | Correlation between cytology and cystoscopy in the follow-up of patients with bladder tumours. | [
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0.06902012228965759,
0.020634... |
10,011,653 | The correlation between cytology and cystoscopy was established using data from 450 cytologic and cystoscopic examinations performed on 401 urology outpatients. Cytology specimens were interpreted by cytopathologists, without access to any clinical information. 311 examinations were performed on patients with present o... | [
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0.01407309714704752,
0.08819154649972916,
0.0362086556... |
10,011,654 | Retroperitoneal epididymal structures in adult male. | [
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0.04773082956671715,
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0.056... |
10,011,655 | Vesicoureteral reflux following transurethral resection of bladder tumours at the ureteral orifice. | [
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0.04216746240854263,
0.00567510025575757,
0.0312001... |
10,011,656 | Idiopathic detrusor sphincter dyssynergia in neurologically normal patients with voiding abnormalities. | [
-0.02278539165854454,
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0.05128102004528046,
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0.04506097733974457,
0.06455551832914352,
0.0495237... |
10,011,657 | Symptomatology and clinical manifestations of detrusor sphincter dyssynergia are described in 23 patients without neurological disease. Their cardinal symptoms were recurrent cystitis, enuresis, frequent voiding, back pain during voiding and anal discomfort. The major objective finding was vesicoureteral reflux in 11 c... | [
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0.030292507261037827,
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0.025242879986763,
0.0635109543800354,
0.0586474... |
10,011,658 | Ureteral and renal endoscopy. A new-approach. | [
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0.049966633319854736,
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0.05255894735455513,
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0.08... |
10,011,659 | Malignant mesothelioma of the tunica vaginalis testis. | [
-0.038564104586839676,
0.1317588984966278,
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0.05749322101473808,
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-0.05388989299535751,
0.0423593707382679,
0.0084205... |
10,011,660 | Vascular leiomyoma of the testicular adnexa. | [
-0.009875412099063396,
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0.004128213971853256,
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0.05883025377988815,
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0.0045308... |
10,011,661 | A plea for standardized grading of vesicoureteral reflux. | [
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0.09... |
10,011,662 | The voiding cystourethrogram has become the accepted standard for detection and grading of vesicoureteral reflux. Although selection of treatment alternatives and interpretation of treatment results are modified by cystographic findings, no uniform grading system exists. This not only makes comparison of different seri... | [
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0.006178793963044882,
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0.07208... |
10,011,663 | Ultrasonographic antenatal detection of obstructed bladder. Diagnosis and management. | [
0.03285563364624977,
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0.0027056920807808638,
-0.09003781527280807... |
10,011,664 | Interagency collaboration: driving and restraining forces. | [
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0.05409642308950424,
0.002322330605238676,
0.04... |
10,011,665 | State special education fiscal policy: the quest for equity. | [
0.005018845200538635,
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0.017594261094927788,
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0.09008462727069855,
0.05456747114658356,
0.08426043391227722,
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10,011,666 | Sign programs with nonverbal hearing children. | [
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0.027997786179184914,
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0.05... |
10,011,667 | Effect of peer presence on psychomotor measures with EMR children. | [
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0.0020778269972652197,
0.0008111970964819193,
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10,011,668 | Assessments of specific behavioral deficits. | [
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0.0016726740868762136,
-0.049369748681783676... |
10,011,669 | Reduction in intraocular pressure induced by colchicine and related compounds. | [
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0.03228503465652466,
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0... |
10,011,670 | The effects of various microtubule inhibitors on the intraocular pressure (IOP) of albino rabbits were investigated. The compounds produced a marked fall in the IOP which was more prolonged after intravitreal injection than after topical administration. Tolerance to this response developed although no cross tolerance b... | [
0.05436773970723152,
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0.0719272717833519,
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0.04201614484190941,
0.0393... |
10,011,671 | Long-term prenylamine therapy: effects on responses to myocardial ischaemia in the isolated rat heart. | [
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0.02866237796843052,
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0.06402021... |
10,011,672 | The effects of long-term administration of prenylamine gluconate were studied to define changes induced by chronic treatment that may alter the responses of the myocardium to ischaemic stress. Prenylamine gluconate was administered orally to rats (10 mg or 100 mg/kg per day) for 2 weeks. At the end of this period, hear... | [
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0.0... |
10,011,673 | Dopaminergic mechanisms in diet-induced thermogenesis and brown adipose tissue metabolism. | [
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10,011,674 | The role of dopamine (DA) in diet-induced thermogenesis was examined. DA was found in, and released from the sympathetic nerves supplying brown adipose tissue. However, the release of DA was only approximately 10% of that of noradrenaline. No significant re-uptake of DA was observed. Hyperphagic, cafeteria-fed rats exh... | [
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10,011,675 | The effect of diltiazem on coronary thrombosis in the conscious canine. | [
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0.106... |
10,011,676 | The effect of diltiazem vs. saline was studied in a conscious canine model of coronary thrombosis. Diltiazem given as a 0.75 mg/kg loading dose intravenously followed by 0.4 mg/kg intravenously every 4 h for 24 h had no significant effect on thrombus wet weight, left ventricular infarct size, frequency of ventricular a... | [
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0.0476694293320179,
-0.0003466633497737348,
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0.... |
10,011,677 | Opiate antagonists stimulate ruminal motility of conscious goats. | [
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0.12202... |
10,011,678 | The effect of opiate antagonists was determined on the extrinsic ruminal contractions of conscious goats. These contractions normally occur approximately once per minute. Naltrexone (greater than or equal to mg/kg, i.v.) and naloxone caused a significant increase in the frequency of ruminal contractions; morphine (0.8 ... | [
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0.1364... |
10,011,679 | Dopamine autoreceptors differ pharmacologically from postsynaptic dopamine receptors: effects of (-)-N-(2-chloroethyl)-norapomorphine. | [
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0.07... |
10,011,680 | Possible physiological role of adrenal and gonadal steroids in morphine analgesia. | [
0.0603439100086689,
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0.0528... |
10,011,681 | The effects of adrenal and gonadal steroids on the antinociceptive potency of parenteral morphine were studied in male rats. At all doses studied, dexamethasone pretreatment 30 min before morphine sensitized the animals to the effects of parenteral morphine. However, at higher doses of dexamethasone this sensitization ... | [
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0.09... |
10,011,682 | Irreversible blockade of responses to a partial agonist acting at the histamine H1-receptor. | [
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0.059927... |
10,011,683 | N,N-Diethyl-2-(1-pyridyl)-ethylamine (E-2-P) has been shown previously to behave as a simple partial agonist at the histamine H1-receptor of guinea-pig ileum. When isolated longitudinal muscle strips from this preparation were tested with E-2-P before and after blockade with 2-haloalkylamines, it was found that these a... | [
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0.04135319963097572,
0.0977... |
10,011,684 | Sulpiride effects on nigral and striatal glutamic acid decarboxylase activity: a possible involvement of prolactin. | [
0.002407121704891324,
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0.0630... |
10,011,685 | Sulpiride, a benzamide derivative neuroleptic, was shown to significantly increase glutamic acid decarboxylase activity in substantia nigra and corpus striatum in either acutely or chronically injected male rats. Hypophysectomy completely prevented this effect suggesting an involvement of an anterior pituitary factor i... | [
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0... |
10,011,686 | Infarct size restriction in cats by the beta-adrenergic blocker timolol. | [
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0.042332... |
10,011,687 | The beta-adrenergic antagonist, timolol, was previously shown to exert a protective effect in cats subjected to 5 h of myocardial ischemia. The present study was designed to determine the effect of timolol on infarct size in cats 24 h after coronary occlusion. Timolol (25 microgram/kg) or vehicle (0.9% NaCl) was admini... | [
0.052575819194316864,
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0.... |
10,011,688 | Selective reduction of adrenaline turnover in the dorsal midline area of the caudal medulla oblongata and increase of hypothalamic adrenaline levels in the Lyon strain of genetically hypertensive rats. | [
0.045402854681015015,
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0.013056422583758831,
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-... |
10,011,689 | Catecholamine levels and turnover have been studied in 5 week old male genetically hypertensive (LH) and normotensive (LN) rats of the Sprague-Dawley Lyon strain. The results demonstrate increased hypothalamic adrenaline levels and a reduced adrenaline turnover in the dorsal midline of the medulla oblongata (DCMO) in t... | [
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10,011,690 | Cardiac electrophysiologic effect of indomethacin. | [
0.03476100414991379,
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0.05485330522060394,
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0.07934124022722244,
0.12... |
10,011,691 | The anti-inflammatory agent indomethacin has been shown to antagonize calcium in smooth muscle. This study looked at indomethacin's effect on ventricular muscle and conduction tissue. Indomethacin shortened the duration of the action potential plateau in the tissue studied. This was probably a result of its interferenc... | [
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0.10725974291563034,
0.154042541... |
10,011,692 | Effect of actinomycin D and cycloheximide on experimental myocardial infarction in rats. | [
0.004219848662614822,
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0.08837492763996124,
0.14260... |
10,011,693 | Actinomycin D, an inhibitor of DNA-directed RNA synthesis, or cycloheximide, a protein synthesis inhibitor, administered 24 h and 1 or 4 h respectively, before inducing coronary occlusion in conscious rats, offered marked protection against postinfarction ventricular fibrillation and sudden death. When actinomycin D wa... | [
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0.07307364791631699,
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0.07045218348503113,
0.0565924309194088,
0.13255... |
10,011,694 | Calcium antagonist receptor binding sites labeled with [3H]nitrendipine. | [
0.03332268074154854,
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0.00803013052791357,
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0.013586286455392838,
0.097... |
10,011,695 | Mechanism of action of histamine in the estrogen-primed rat uterus. | [
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0.10082835704088211,
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0.006721972953528166,
0.04... |
10,011,696 | Histamine produced a dose-dependent relaxation of uterine strips obtained from the estrogen-primed rat uterus. The responses to histamine were blocked competitively by metiamide (10(-8)-10(-8) M), a specific H2-receptor antagonist. Propranolol, a selective beta-receptor blocker also produced competitive antagonism of t... | [
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0.0677676... |
10,011,697 | Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468). | [
0.023803364485502243,
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... |
10,011,698 | Experiments were designed to determine whether or not ketanserin (R 41 468) antagonizes the augmentation by 5-hydroxytryptamine of contractions evoked in isolated arteries by non-adrenergic vasoconstrictor substances. Rings of rabbit femoral arteries were studied under isometric conditions in organ chambers filled with... | [
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0.04317145049571991,
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0.016260627657175064,
0.05... |
10,011,699 | Irreversible blockade of striatal dopamine receptors in vivo by a derivative of alpha-flupenthixol. | [
0.1066833958029747,
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0.03904038295149803,
0.013809947296977043,
0.04126... |
10,011,700 | Flupenthixyl chloride (FPT-Cl), a derivative of the dopamine (DA) receptor antagonist and neuroleptic alpha-flupenthixol possessing a chloroethyl side chain, has been prepared and evaluated for use in vivo in affinity labeling of DA receptors. Binding of [3H]spiperone to rat striatal DA receptors was markedly altered u... | [
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0.014718238264322281,
0.03522142395377159,
0.06885... |
10,011,701 | Effect of unilateral carotid ligation on brainstem PNMT activity. | [
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0.07960773259401321,
0.043598536401987076,
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0.03319... |
10,011,702 | Phenylethanolamine N-methyltransferase (PNMT) activity in the C1 and C2 regions of the brainstem was assayed in normotensive Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) with or without unilateral carotid artery ligation. PNMT activity was significantly higher in SHR than in WKY (P less than 0.01).... | [
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0.034018438309431076,
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-0.05479605495929718,
0.0... |
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