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10,002,500 | Identifying the sources of the recent decline in perinatal mortality rates in California. | [
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10,002,501 | The perinatal mortality rate in California decreased rapidly in the 1970s; neonatal mortality fell about twice as fast as fetal mortality. Decreases in birth-weight-specific mortality accounted for 81 per cent of the decline in the perinatal rate, with only 19 per cent due to improvements in birth weight. No improvement was observed in the birth-weight distribution for blacks. The decrease in mortality rates was significantly faster for cesarean deliveries than for vaginal births. By 1977, all birth-weight-specific fetal mortality rates for cesarean sections were equal to those for vaginal deliveries or lower. For infants weighing less than 2000 g, perinatal mortality rates were also significantly lower for infants born by cesarean section than for infants delivered vaginally. These results suggest that much of the recent decrease in perinatal mortality rates can be attributed to the advent of neonatal intensive care and the increased rate of cesarean section. | [
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10,002,502 | Case records of the Massachusetts General Hospital. Weekly clinicopathological exercise. Case 4-1982. Sudden onset of renal failure and the nephrotic syndrome in a middle-aged woman. | [
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10,002,503 | Treatment of venous thrombosis with subcutaneous heparin. | [
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10,002,504 | A tactic of last resort. | [
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10,002,505 | Closing the books on Laetrile. | [
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] |
10,002,506 | Kawasaki syndrome. | [
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10,002,507 | Calcium for myocardial depression from verapamil. | [
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10,002,508 | Regional body temperature and disease. | [
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10,002,510 | Predicting relapse in acute bronchial asthma. | [
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] |
10,002,511 | As the twig is bent... | [
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10,002,513 | Microvascular transfer of free tissue for closure of bone wounds of the distal lower extremity. | [
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10,002,514 | Extensive compound fractures of the distal lower extremity may result in chronic infection of the deep tissues and bone if primary healing does not occur. Treatment may require several operations and prolonged hospitalization. In an attempt to improve the management of such problems, 18 patients who had chronic bone-exposure wounds and four patients who had extensive compound fracture wounds of the distal lower extremity were treated with radical debridement, intravenous antibiotics, and microvascular transfer of vascularized tissues for immediate wound closure. All wounds healed, and there was no evidence of recurrent infection during a mean follow-up period of 19.3 months in the patients with chronic wounds and 16.3 months in those with acute wounds. In selected patients this free-tissue-transfer method of wound closure appears to have considerable advantages over conventional methods of management. | [
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10,002,515 | An association between neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia in three kindreds. | [
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10,002,516 | Four cases of neonatal severe primary hyperparathyroidism occurred in three families; familial hypocalciuric hypercalcemia was present in each kindred. The diagnosis of familial hypocalciuric hypercalcemia was based on the following features; hypercalcemia in many relatives (eight to 16 per kindred), without other features of the multiple endocrine neoplasia syndromes; recognition of hypercalcemia before the age of 10 in one to three relatives; hypocalciuric hypercalcemia in all relatives tested (five to 14 per kindred); and abnormal serum calcium levels despite parathyroidectomy in all additional relatives (one to five per kindred) undergoing this operation. The association of two uncommon syndromes (neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia) in these kindreds suggests that the two syndromes share a common genetic cause within each kindred. | [
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10,002,517 | Cutaneous localization of the membrane attack complex in discoid and systemic lupus erythematosus. | [
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10,002,518 | Biopsy specimens of skin lesions from three patients with discoid lupus erythematosus and six patients with systemic lupus erythematosus contained the membrane attack complex, which comprises C5b through C9, as well as immune complexes at the dermal-epidermal junction. The basilar epithelium in these areas was vacuolated and edematous, and the dermis contained an inflammatory infiltrate. In contrast, 19 of 29 specimens of normal-appearing skin from patients with discoid or systemic lupus erythematosus showed only immune complexes at the dermal-epidermal junction, without the membrane attack complex. The other 10 specimens, all from patients without cutaneous involvement, showed neither immune complexes nor membrane attack complexes. These data suggest that immune complexes within skin lesions selectively generate the assembly of the membrane attack complex, which mediates membrane injury. A synergistic interaction of immune complexes and cofactors may be required to activate complement in areas of skin that are predisposed to tissue injury. | [
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10,002,519 | The impact of early specialization on the clinical competence of residents. | [
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10,002,520 | To study the relation between first-year postgraduate training and performance on a test of general clinical competence, we analyzed results on the Part III National Board Examination according to the type of residency chosen by 1514 graduates of Jefferson Medical College between 1970 and 1979. The results show that physicians in family medicine, internal medicine, or flexible programs score higher on Part III than do those in surgery, pediatrics, obstetrics/gynecology, psychiatry, or pathology, even after correction for their performance on Part II of the boards. Although these differences could be due to other factors, we suggest that in the first year of some residency programs, knowledge and skills in broad areas of medicine are not being sufficiently emphasized, and that changes are needed to strengthen the residents' general capabilities. | [
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10,002,521 | Thrombosis as a complication of pulmonary-artery catheterization via the internal jugular vein: prospective evaluation by phlebography. | [
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10,002,522 | Autoimmune hemolytic anemia with reticulocytopenia and erythroid marrow. | [
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10,002,523 | Violence and epilepsy. | [
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10,002,524 | The muscle flap for management of osteomyelitis. | [
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10,002,525 | Intracoronary thrombolysis with streptokinase in acute myocardial infarction. | [
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10,002,526 | Danger of evacuated bottles for phlebotomy. | [
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10,002,528 | Pathology and probabilities. | [
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] |
10,002,529 | The Ingelfinger rule and the "right to know". | [
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] |
10,002,530 | Bakke decision revisited. | [
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] |
10,002,531 | A protocol for selecting patients with injured extremities who need x-rays. | [
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10,002,532 | To help curb excessive radiography, we developed a protocol for selecting patients with injured extremities who need x-ray examination, and we tested the protocol prospectively in 848 patients to determine its safety and effectiveness. Strict adherence to the protocol would have reduced x-ray usage by 12 per cent for upper extremities and 19 per cent for lower extremities. The actual reductions were 5 per cent and 16 per cent, respectively, since further reductions were limited by patient's demands for x-ray examinations. One fracture in 287 were missed, but the treatment was appropriate and the outcome satisfactory. By eliminating superfluous x-ray procedures, the protocol could reduce charges by $79 million to $139 million nationwide, without compromising quality of care or increasing malpractice liability. Nevertheless, even the best protocol cannot eliminate all negative x-ray studies. These results should serve as a stimulus for judicious use of radiography, but also as a warning to avoid overzealous cost-containment strategies that would reduce x-ray usage to below a safe threshold. | [
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10,002,533 | Successful treatment of primary amebic meningoencephalitis. | [
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10,002,534 | Steroids in the treatment of brain edema. | [
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10,002,536 | The syndrome of nonthrombocytopenic purpura with eosinophilia: an acquired platelet dysfunction. | [
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10,002,537 | More on diagnosing fractures of the hip or pelvis. | [
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] |
10,002,538 | Lead-associated intellectual deficit. | [
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] |
10,002,539 | Sex ratio in offspring of patients with non-Hodgkin lymphoma. | [
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10,002,541 | Profits and the end-stage renal-disease program. | [
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10,002,542 | Two cases of normally masculinized males with low titers of H-Y antigen. | [
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] |
10,002,543 | Family secrets: who is to know about AID? | [
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] |
10,002,544 | [Anniversary competition: which requirements of form and content should be satisfied in a general medical scientific weekly in your opinion? Jury report on contributions for the competition of the Nederlands Tijdschrift voor Geneeskunde on the occasion of its 125th anniversary]. | [
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10,002,545 | [Prize paper submitted under the slogan of : Golden apples on silver platters. Which requirements of form and content should be satisfied in a general medical science weekly in your opinion?]. | [
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10,002,550 | Crystal ball gazing: the general journal in the year 2000. | [
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10,002,551 | [Arrogance]. | [
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10,002,552 | [Chronic carbon monoxide poisoning]. | [
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10,002,553 | [Brain abscess: new insights in diagnosis and treatment]. | [
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10,002,554 | [Temporal arteritis]. | [
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10,002,555 | [The practical initial management of pseudocroup]. | [
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10,002,556 | [Carbon monoxide poisoning]. | [
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10,002,557 | [Pumps for insulin infusion]. | [
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10,002,558 | Current status of intrauterine devices. II. Intrauterine devices and pelvic inflammatory disease and ectopic pregnancy. | [
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10,002,559 | The suspected causal relationship between use of different types of IUDs and pelvic inflammatory disease and ectopic pregnancy are reviewed. The information available at this time regarding the IUD and pelvic inflammatory disease (PID) in the early IUDs, the Lippes loop and other polyethylene devices, the copper-containing devices, and the progesterone-containing devices. Grafenberg, in 1929, reported 17 cases of inflammation following insertion of silk IUDs which had been placed entirely within the uterine cavity. He found no such evidence following insertion of 150 silver rings. Oppenheimer inserted 1500 rings and did not find any complication such as inflammation, fever, or infection as a result of the ring insertion. In regard to the Lippes loop and other polyethylene devices, investigators in 1 study accumulated 15,419 woman-months experience with 1531 first insertions. The incidence of PID was 1.6%. Another group of investigators reported a 7.7% incidence of PID in a group of 623 clinic patients who were using IUDs. Lippes reported a rate of 0.6/100 woman-years for 1673 patients during 16,077 woman-months of exposure. It has been suggested that the IUD tails may be responsible for the passage of vaginal bacteria into the uterus. A lower incidence of bacterial contamination of the uterine cavity with copper devices as compared with others has been demonstrated. It has been observed that the PID rate in 750 women using the Copper T-200 for 1 year after insertion was 2.1%. A group of investigators reviewed the incidence of PID in 516 never pregnant women using Copper 7 IUD for 9080 woman-months at 4 centers. The incidence of PID varied between 0.9-1.4% per year in different centers. It was found that the rate of PID in women using Progestaserts was between 2 and 3.1% per year, and it was strongly correlated with the history of PID. Comparative trials are reported along with studies relating to the use of IUDs and an increased risk of ectopic pregnancy. A positive relationship between the duration of IUD use the risk of ectopic pregnancy has been observed. An investigator reviewed his experiences of 711 ectopic pregnancies; 70 of these were associated with the use of an IUD, which comprised 10% of all the ectopics in a 9-year period. A prevalence of about 21% extrauterine pregnancies among the Progestasert IUD users, as against 2.5% among other IUD users. Little information is available regarding whether, after removal of the IUD, the woman is still at a higher risk of tubal pregnancy at a subsequent pregnancy. | [
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10,002,560 | [Ocular herpes simplex in children (author's transl)]. | [
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10,002,561 | A series of 38 children with ocular herpes simplex infection is reported. The follow-up periods ranged between 1 and 10 years after the first ocular herpetic involvement. The primary ocular infection occurred in most cases between 2 and 6 years of age, with a similar rate in males and females. The number of recurrences increased with the duration of the follow-up period: during the first 2 years, recurrences developed in 50% of cases and after 2 years, all the children had new herpetic ocular attacks. Idoxuridine treatment failures were found in 11 cases of herpetic superficial keratitis. Ocular herpes simplex in children is a major cause of visual loss and disability. After a follow-up period of 5 years, 75% of patients with herpetic keratitis had a visual acuity of 5/10 or less. | [
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10,002,562 | Dystrophia retinae pigmentosa, fundus flavimaculatus and Stargardt's disease in one family. | [
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10,002,563 | This paper describes a family, the propositus of which suffers from dystrophia retinae pigmentosa combined with fundus flavimaculatus and Stargardt's disease. The patient's mother and a maternal uncle suffer from a dystrophia retinae pigmentosa, whereas a sister shows peripheral degenerations. A further sister has a scotopic b wave of the ERG of low amplitude. | [
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10,002,564 | [The tilted disc syndrome: differential diagnosis of chiasmatic disorders (author's transl)]. | [
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10,002,565 | Kearns syndrome or Kearns disease. Further evidence of a genuine entity in a case with uncommon features. | [
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10,002,566 | A 20-year-old man with the characteristic findings of infantile onset Kearns syndrome is described. Morphological and biochemical investigations proved a mitochondrial disease which we believe to be the cause of the symptoms in various organs. We assume an autosomal-dominant inheritance, the marker sign of which is blepharoptosis in several family members. Characteristic clinical, morphological and biochemical findings, combined with an autosomal-dominant inheritance with very variable expression, mark the Kearns syndrome as an individual disease, not as a symptom complex (syndrome). Kearns disease can be divided into three forms--an infantile form ("Kearns-Sayre syndrome') with early onset, rapid progression, multisystemic involvement and a severe course; and a juvenile and an adult form with onset in the second, respectively third (or later) decades with a generally slower and more benign course and less widespread expression in various organ systems. Furthermore, the occurrence of a curious orthoptic abnormality is described, indicating one of the possible ways to avoid diplopia in chronic progressive external ophthalmoplegia: the coexistence of normal and gliding abnormal retinal correspondence. | [
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] |
10,002,567 | [Choroidal miliary tuberculosis: fluoroangiographic study (author's transl)]. | [
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] |
10,002,568 | The authors have followed the evolution of disseminated choroidal tuberculosis during a period of 16 months. At the beginning of the disease, fluorescein angiography showed an early 'screen effect' and later a 'focus effect'. During the later stage of the disease, the pigmented epithelium was seen to be involved as well, as demonstrated by (1) the presence of advanced pigmented chorioretinitis at the sites where the tubercles were observed at the beginning of the disease and (2) the presence of fluorescent areas early during fluorescein angiography. | [
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10,002,569 | Prophylactic antibiotics in pediatric surgery. | [
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10,002,570 | The frequency and appropriateness of prophylactic antibiotic use in children less than 6 years of age who received surgery were examined. Antibiotics were prescribed for 62% of children who had surgery, and prophylaxis was the sole reason for antibiotic use in 73% of the patients. Prophylactic antibiotics were administered inappropriately with respect to timing or duration to 42% of the children receiving preoperative prophylaxis, 67% receiving intraoperative prophylaxis, and 55% receiving postoperative prophylaxis. Thus, prophylaxis alone is the major indication for antibiotic use in pediatric surgical patients, and prophylactic antibiotics are frequently administered inappropriately. | [
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10,002,571 | American Academy of Pediatrics Committee on Genetics: New issues in newborn screening for phenylketonuria and congenital hypothyroidism. | [
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10,002,572 | Evaluation of the Minolta bilirubin meter as a screening device in white and black infants. | [
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] |
10,002,573 | Asymptomatic neonatal familial hypercalcemia. | [
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] |
10,002,574 | Hypervitaminosis A: a case report. | [
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] |
10,002,575 | Correlation between blood ammonia concentration and organic acid accumulation in isovaleric and propionic acidemia. | [
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10,002,576 | Near fatal hyperkalemia from a dangerous treatment for colic. | [
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10,002,577 | Dog bites in children less than 4 years old. | [
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10,002,578 | Growing up too fast. | [
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10,002,579 | Transcutaneous bilirubinometry: a new light on an old subject. | [
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10,002,580 | Neurologic findings with maternal hyperthermia. | [
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10,002,582 | Sex and respiratory distress syndrome. | [
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10,002,583 | Lead study questioned. | [
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10,002,584 | Role of self-esteem and autonomy in determining medication compliance among adolescents with juvenile rheumatoid arthritis. | [
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10,002,585 | This study was designed to improve understanding of adolescents' compliance with medical regimens. Compliance with salicylate therapy among adolescents with juvenile rheumatoid arthritis was examined in relationship to two of the most important issues of adolescent psychosocial development--self-image and autonomy. Standardized instruments that assessed these variables were administered to 38 adolescents with juvenile rheumatoid arthritis during the year in which compliance was determined, utilizing serum salicylate measurements. Patients and disease-related characteristics were also recorded, and interactions with personality variables were examined. The data show that adolescents with juvenile rheumatoid arthritis who comply with their medical regimen are those who have high self-esteem and are allowed more autonomy than the noncompliers. The longer the duration of the illness and the more symptoms present at onset, the poorer was self-concept, and hence compliance, at adolescence. | [
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10,002,586 | Playground injuries and voluntary product standards for home and public playgrounds. | [
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10,002,587 | Accidents on home and public playgrounds account for more than 150,000 injuries per year. The Division of Hazard Identification and Analysis in the Bureau of Epidemiology has studied playground injuries. Swings, climbing apparatus, gliders, slides, and seesaws were listed as apparatuses associated with the highest percentages of injuries. Falls to the surface also accounted for a large percentage of injuries. Absorbent surfaces other than concrete or asphalt were recommended to reduce the severity of injuries. In addition to making recommendations on playground surfaces, the Consumer Product Safety Commission has developed voluntary product safety standards for home and public playgrounds. Guidelines for safe playgrounds are discussed as well as suggestions concerning people to contact at local, state, and national levels for advice on playground design and safety. | [
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10,002,588 | A simple method of assessment of gestational age in newborn infants. | [
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10,002,589 | A simple method of assessment of gestational age based on only four characteristics, namely, the anterior vascular capsule of the lens, plantar creases, breast nodule, and ear firmness, is presented. Critical evaluation by appropriate statistical analyses has shown this to be a useful method of practical value with 95% confidence limits of 11 days. It is applicable to newborn infants, including sick babies, at any time within the first 2 days of life. | [
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10,002,590 | Retardation of neuronal maturation in premature infants compared with term infants of the same postconceptional age. | [
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10,002,591 | Neuronal morphologic development and the number of soma and spines in the visual cortex were investigated. Ten premature infants surviving at least three weeks were compared with control infants who had been born at term gestation and had the same postconceptional age. In six cases of sudden infant death syndrome, bronchopulmonary dysplasia, or patent ductus arteriosus, neuronal development was similar to that in the control cases. The persistence of immature neurons in two of the remaining four cases suggested a developmental neuronal delay or arrest. | [
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10,002,592 | Decrease in pulsatile flow in the anterior cerebral arteries in infantile hydrocephalus. | [
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] |
10,002,593 | The effect of ventriculomegaly with or without elevated intracranial pressure (ICP) on pulsatile flow in the anterior cerebral artery has been studied by a noninvasive Doppler technique in 11 infants with hydrocephalus. The cause of hydrocephalus was intraventricular hemorrhage in nine infants, Arnold-Chiari malformation in one, and bacterial meningitis in one. The pulsatility index (PI) (inversely related to pulsatile flow) was calculated from the systolic and diastolic amplitudes of flow in the anterior cerebral artery. All 11 patients with elevated PI had marked ventriculomegaly, and all but two had raised ICP. Four patients with massive ventriculomegaly and elevated ICP had maximal PI (ie, 1.00). The finding of elevated PI with ventriculomegaly and normal ICP, observed in two patients, suggested that ventriculomegaly is a more critical factor than ICP in the pathogenesis of the impaired flow. Treatment of ventriculomegaly in seven patients resulted in a decrease in PI. Of the four untreated patients, three died and one was not available for further study. Compromised flow in the anterior cerebral artery may be a sensitive barometer of impending ischemic injury with evolving ventriculomegaly, particularly following intraventricular hemorrhage. The PI may be a valuable parameter for the study of the mechanism of brain injury and for determination of optimal timing of corrective intervention. | [
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10,002,594 | Failure of hydrocortisone to affect outcome in dengue shock syndrome. | [
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10,002,595 | Despite the absence of a clear-cut rationale for their use, corticosteroids are widely employed in the treatment of dengue shock syndrome. Previous comparative therapeutic trials have yielded contradictory results. Resolution of this therapeutic controversy has been attempted with a double-blind evaluation of the clinical effect of steroid administration in dengue shock syndrome. Placebo or a single dose of hydrocortisone hemisuccinate, 50 mg/kg of body weight, was administered randomly to 97 physiologically treated patients with dengue shock syndrome. The severity of disease on admission to the hospital and the effectiveness of treatment were quantified by a World Health Organization scoring system. The response to therapy as measured by mortality, duration of shock, and amount of replacement fluids required was virtually identical in 47 children who were and 50 children who were not treated with steroids. The comparison groups were composed of children similar in age, sex, and severity of illness. It is concluded that hydrocortisone is of no value in the treatment of dengue shock syndrome. Reliance should be placed on appropriate supportive and physiologic therapy. | [
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10,002,596 | Occlusive lesions of cardiac conducting tissue arteries in sudden infant death syndrome. | [
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10,002,597 | Cardiac conducting tissue from the hearts of 40 victims of sudden infant death syndrome was examined microscopically by serial section. In five hearts there were marked narrowing of the major artery supplying the atrioventricular node. In another there was similar narrowing of the artery supplying the sinus node. The arterial lesions were focal and characterized by cellular intimal thickening which severely narrowed the vessel lumen. This arterial anomaly may be a contributory factor in the pathogenesis of some cases of sudden infant death. | [
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10,002,598 | Lactic acidemia in Reye's syndrome. | [
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10,002,599 | Plasma lactate level was measured in 21 patients with Reye's syndrome and was compared with neurologic state as rated on a simple coma scale. Significant elevations in plasma lactate, ranging from 2 to 15 mEq/liter, were noted in all patients. There was a close correspondence between stage of coma at the time the sample was drawn and lactate levels. The correlation of plasma lactate level with clinical stage could not be accounted for by differences in glucose. PO2, PCO2, pH, blood pressure, or serum osmolality. In contrast, blood ammonia level correlated with the severity of the encephalopathy early in the course only and often returned to normal in patients with persistent coma. Only measurements of hepatic dysfunction such as SGOT and SGPT levels of failed to correlate with clinical state. All patients had a metabolic acidosis; in five patients it was uncompensated. Lactate accounted for nearly all (mean 81%) of the observed base deficit. The findings suggest that lactic acidemia is an important metabolic component of Reye's syndrome. | [
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