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10,003,200 | As part of a prospective study investigating maternal characteristics and habits during pregnancy and their impact on fetal development, 1,690 mother/infant pairs were studied. Of the mothers, 375 reported using Bendectin during pregnancy. Multivariate analyses examining birth weight, length, head circumference, gestational age, and congenital malformations as dependent variables demonstrated no associations between Bendectin exposure and adverse fetal outcome. | [
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10,003,201 | Follow-up of a survivor of intrauterine lightning exposure. | [
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10,003,202 | Delivery obstructed by sacrococcygeal teratoma. | [
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] |
10,003,203 | Management of labor with umbilical cord prolapse. | [
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10,003,204 | Intrauterine fetal transfusion: monitoring intraperitoneal pressures. | [
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10,003,205 | Retained chorionic membrane following repeated amniocenteses. | [
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] |
10,003,206 | External hypoxia and corneal hydration dynamics. | [
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10,003,207 | Optical pachometry was used to monitor thickness increases in six human corneas exposed to an anoxic external environment. Corneal swelling was observed to occur to an extent consistent with an earlier study (5%/hr or 25mu m/hr). Use of Darcy's law allows analysis of the "pump-leak" equilibrium, which leads to the conclusion that any direct interference by surface anoxia affecting corneal hydration must be at the endothelial side of the cornea. | [
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] |
10,003,208 | In office angle-closure precipitation management. | [
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10,003,209 | Contrast sensitivity predicts pilots' performance in aircraft simulators. | [
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10,003,210 | Contrast sensitivity was found to be better than visual acuity for predicting a pilot's ability to detect a small, semi-isolated, air-to-ground target. Eleven instructor pilots had their acuity measured by both conventional and contrast sensitivity methods. Scotopic contract sensitivity showed the highest correlation with slant detection range (0.83). Conventionally determined visual acuity proved to be a poor predictor of a pilot's ability to detect a small low contrast target. | [
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10,003,211 | Effects of contact lens deformation on tear film pressures induced during blinking. | [
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10,003,212 | The pressures induced in a tear film between a contact lens and the eye during the initial stages of a blink are estimated by means of a flexible slider-bearing model. Calculations are made of the pressure distributions as functions of two nondimensional parameters, one of which is purely geometrical and the other involves the sliding velocity, the viscosity of the tear film, and the flexibility of the lens. For the dimensions and velocities which apply to a typical blink, it is found that the effects of soft lens deformation in reducing pressure can be significant, especially for small tear film thicknesses. | [
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] |
10,003,213 | Human response to cyclofusional stimuli containing depth cues. | [
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10,003,214 | The cyclofusional response to stimuli containing depth cues was studied. Eye positions were monitored by an objective, binocular, eye movement measuring technique while a psychophysical method was used to measure the stereoscopic responses. We found that the overall response contains both stereoscopic and cyclofusional components and that the cyclofusional response includes a large nonmotor, or sensory, contribution. The composition of the response was unaffected by changes in stimulus size. Increased stimulus complexity elicited larger cyclotorsional eye movements and diminished the amount of perceived inclination which was observed in the fused percept. | [
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10,003,215 | Component and correlation ametropia. | [
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10,003,216 | The average axial length for eyes grouped according to refractive error must vary as a function of refractive error. In fact, this change in the average axial length can account almost totally for the change in refractive error. This finding is incompatible with the usual interpretation of correlation ametropia. When the categorization of eyes is based on axial length rather than on refractive error, then a more statistically meaningful division of eyes into component and correlation categories is achieved. | [
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10,003,217 | Optical density of the crystalline lens. | [
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10,003,218 | The optical density for the noncataractous crystalline lens is written as a sum of two terms, each with a specific dependence on wavelength. The first term, proportional to 1/lambda 2, represents all light-scattering processes in the lens. The second term, assumed significant only for lambda less than or equal to 500 nm, accounts for absorption by lens pigments. By analyzing transmittance data on lenses of subjects aged 21 to 63 years, a spectrum for light absorption by lens pigment is derived and it is shown to be essentially the same for all of the lenses. | [
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10,003,219 | Biochemical and surface characteristics of human tear proteins. | [
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10,003,220 | Pooled human tear samples were subjected to biochemical and surface chemical analyses. Gel filtration chromatography yielded four fractions. The second fraction was the most surface active, closely followed by the first. By ionic exchange chromatography, the first fraction obtained by gel filtration chromatography could be further separated into three subfractions. The second of these subfractions was found to be the most surface active, even surpassing the combined surface activity of all the tear components. Altogether eleven protein components were identified in human tears by gradient polyacrylamide gel electrophoresis with sodium dodecyl sulfate (SDS). Their molecular weights range from 16,000 to 400,000 daltons. Isoelectric focusing indicated that most of the tear proteins are negatively charged, whereas the rest are positively charged at physiological pH's. | [
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10,003,221 | The AC/A ratio and convergence in hypermetropia corrected with spectacles or contact lenses. | [
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10,003,222 | Some hypermetropes, when corrected with contact lenses, appear to have a much smaller AC/A ratio than when corrected with spectacle lenses. Ocular convergence measured with contact lenses is greater than that measured with spectacles. Studies were carried out to establish the cause of these effects. Theoretical considerations are compared with the experimental results obtained. This study emphasizes the importance of the different amounts of magnification induced by contact lenses as compared with spectacles. | [
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10,003,223 | Measurement of interpupillary distance with chromostereopsis. | [
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] |
10,003,224 | Chromostereopsis is a perceived depth difference between coplanar objects of different color and can be used for highly accurate measurement of interocular separation (PD). A survey of PD measurement with chromostereopsis and with the PD rule on 83 subjects shows that these methods on average result in the same PD, indicating that chromostereopsis is a valid technique for PD measurement. Repeated PD measures by these 83 individuals on the authors, using the PD rule and chromostereopsis, shows that the chromostereopsis result is far more repeatable than the PD rule. Suggestions are made for the use of the chromostereopsis technique in optometric practice. | [
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] |
10,003,225 | The validity of a screening test. | [
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] |
10,003,226 | Many health professionals screen for the early detection of disease. Unfortunately, many of the tests and programs have poor validity or are applied to screening populations where the prevalence of disease precludes efficient screening operations. The epidemiological concepts of validity testing are presented to aid those designing or implementing screening programs. | [
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10,003,227 | Determination of photoslitlamp exposure settings. | [
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10,003,228 | An apparent case of butterfly-shaped pigment dystrophy of the fovea. | [
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] |
10,003,229 | This 44-year-old patient showed a distinctive bilateral pigmentary lesion of the macula which led to the tentative diagnosis, butterfly-shaped pigment dystrophy of the fovea. This is an extremely rare condition, with only a handful of cases reported in the literature. The disease is described, along with the rationale used in making the diagnosis. | [
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10,003,230 | The effects of PUVA on the eye. | [
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10,003,231 | Psoriasis is a common skin disease which may be treated with 8-methoxy psoralen and long-wave ultraviolet light (PUVA). Eye protection is provided during and after treatment to prevent the development of photokeratitis and cataracts. Fifteen patients, treated with medication and ultraviolet A (UVA) had an initial complete eye examination and a repeat examination after each treatment. No patients developed cataracts but almost one-half of the patients had a mild form of photokeratoconjunctivitis. The ocular manifestations included photophobia, conjunctivitis, keratitis, and dry eyes. Tear break-up time was reduced significantly immediately after treatment for two patients but returned to normal 8 hr later. Dermatologists who employ PUVA treatments should be concerned about photokeratoconjunctivitis and the dry-eye ocular manifestations included photophobia, conjunctivitis, keratitis, and dry eyes. Tear break-up time was reduced significantly immediately after treatment for two patients but returned to normal 8 hr later. Dermatologists who employ PUVA treatments should be concerned about photokeratoconjunctivitis and the dry-eye ocular manifestations included photophobia, conjunctivitis, keratitis, and dry eyes. Tear break-up time was reduced significantly immediately after treatment for two patients but returned to normal 8 hr later. Dermatologists who employ PUVA treatments should be concerned about photokeratoconjunctivitis and the dry-eye syndrome. | [
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10,003,232 | Reduced acuity and its relation to blur threshold measurements in optometric tests. | [
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10,003,233 | Sensitivity to blue was investigated in a group of subjects having long-standing reduction of visual acuity, and in another group of subjects whose acuity was reduced for the purpose of the study. The distributions of scores was compared with those of a previous study of subjects with normal acuity. The reduction of acuity produced a shift in both distributions, the greater shift occurring in the second group. | [
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10,003,234 | Degeneration and calcification of bioprosthetic cardiac valves. Bioprosthetic tricuspid valve implantation in sheep. | [
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10,003,235 | The pathologist and the sudden infant death syndrome. | [
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10,003,236 | Effects of irradiation on macrophagic response and transport of particles across the alveolar epithelium. | [
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10,003,237 | Macrophagic production and particulate penetration into the lung were studied in mice depleted of monocytes by whole body irradiation. Subsequent intratracheal instillation of 4 mg carbon resulted in a much smaller adaptive increase in the number of alveolar macrophages, as compared with nonirradiated animals. The decreased macrophagic output was associated with increased passage of free carbon across the Type 1 alveolar epithelium in increased accumulation of carbon in interstitial macrophages and hilar lymph nodes of irradiated mice. The results suggest that interference with the adaptive outpouring of alveolar macrophages following a particulate load facilitates the interaction of particles with macrophages within the pulmonary interstitium, where fibrogenic factors released in response to toxic agents would have a maximum effect. | [
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10,003,238 | Morphology of irradiated microvasculature: a combined in vivo and electron-microscopic study. | [
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] |
10,003,239 | The purpose of this study was to establish a standardized experimental system to investigate the local effects of ionizing irradiation in the absence of systemic responses due to radiation. Twenty fully healed rabbit ear chambers in 13 rabbits were irradiated with single exposures of 7500 rads of beta-rays from a strontium-90 source. The irradiation resulted in an acute response, with cellular infiltration of the ear chambers, loss of vasomotion in arterioles, and vasodilatation. Over the weeks following irradiation, a gradual reduction in the number of blood and lymphatic vessels was noticed. A gradual reduction in the number of cells in the interstitium was also observed. Finally, only a few thin-walled blood vessels remained. Their endothelium contained no recognizable organelles and in places had disappeared completely, to expose the vascular basement membrane to the blood. These vessels were observed to be still flowing. No evidence either of capillary blockage due to swelling of endothelial cells or of platelet aggregation leading to thrombosis was obtained. | [
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10,003,240 | Intrahepatic portal vein sclerosis in patients without a history of liver disease. An autopsy study. | [
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10,003,241 | Portal fibrosis with portal venous obliteration is characteristic of noncirrhotic portal hypertension, but similar lesions are also commonly seen in patients without clinical evidence of liver disease. Thus, the ability to predict the presence of portal hypertension with histologic criteria will probably depend on a quantitative assessment of liver tissue. The purpose of this study is to provide a quantitative basis in a "normal" population for evaluation of portal vein obliteration. We reviewed 414 consecutive autopsies of patients without known history of alcoholism or clinical liver disease. Intrahepatic portal vein obliteration was graded 0 to III. The grading system was standardized by morphometry on 34 selected cases. The incidence of portal vein lesions increased with age and reached a plateau at about 60 years of age. Lesions were more common in patients who had severe congestive heart failure or arterial thrombosis. These associations suggest that obliterative lesions may be the result of thrombosis in patients with sluggish portal blood flow or hypercoagulability. Portal tract mineral oil deposits may also have a role, because they were found more often than expected in livers with portal sclerosis. | [
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10,003,242 | Metaplastic changes of nasal respiratory epithelium in rats exposed to hexamethylphosphoramide (HMPA) by inhalation. | [
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10,003,243 | Rats exposed by inhalation to hexamethylphosphoramide (HMPA) at concentrations of 50, 100, 400, and 4000 parts per billion (ppb) for 6-24 months revealed nasal tumors and squamous metaplasia with inflammation in the nasal epithelium, but no changes were observed at 10 ppb. The ciliated cells were most susceptible to HMPA, showing degenerative changes, with abnormal cilia and extensive deciliation. The desquamated nasal epithelium was repaired initially by undifferentiated mucus or microvillous cuboidal cells, and subsequently the lining cells were replaced with squamous cells migrating upward from the basal layer. In the early stage of squamous metaplasia, thickened nasal epithelium revealed indifferent cells, undifferentiated glandular cells, transitional cells from glandular to squamous cells, poorly differentiated squamous cells, and intermediate cells showing features of glandula and squamous differentiation. Subsequently, the undifferentiated glandular cells were replaced mainly with the squamous or intermediate cells. the undifferentiated glandular cells appeared to be biphasic reserve cells capable of differentiating to glandular or squamous cells. The intermediate cells appeared to be derived from the undifferentiated glandular cells and converted into keratinizing squamous cells. Numerous secretory vesicles and mucus droplets were observed in the squamous cells adjacent to the keratinized area and keratin plates. | [
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10,003,244 | Crotalaria-induced pulmonary hypertension. Uptake of 3H-thymidine by the cells of the pulmonary circulation and alveolar walls. | [
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] |
10,003,245 | Feeding with Crotalaria spectabilis seeds induces structural changes in the pulmonary arterial circulation characteristic of pulmonary hypertension: increased medial and adventitial thickness, the appearance of muscle in smaller arteries than normal, and reduction in the number of peripheral arteries. By autoradiographic techniques, after injection of 3H-thymidine into rats fed Crotalaria for 3, 7, 14, 21, 28, or 35 days, the contribution of hyperplasia to these changes has been assessed at two levels of the pulmonary artery--the hilum and the periphery. In the hilar pulmonary artery, a biphasic increase in labeling index (LI) is seen in each cell type. After 3 days of feeding, the medial smooth muscle cells show a slight but significant increase (1.5 times the control value), and, after 7 days, so do the adventitial fibroblasts (3 x) and the endothelial cells (EC) (2 x). After 14 days LI for all three cell types is again at control values, but after 21 days (wall thickness is no increased) each cell type shows at least a fivefold increase; by 35 days all are again near control levels. In the intra-acinar region, by 14 days, "newly" muscularized arteries are identified and increase in number and proportion up to 35 days; 3H-thymidine uptake is not evident in this cell type until 35 days have passed. The ECs of these arteries, however, show a striking increase in LI after 14 days as do those of the alveolar capillaries. The ECs of the intra-acinar veins show a biphasic response being increased after 7, 28, and 35 days. The present study has shown that Crotalaria ingestion induces hyperplasia and hypertrophy of pulmonary arterial cells at pre- and intra-acinar levels. The early increase in LI probably represents a response to the original cell injury, the later changes, a response to continuing damage or, in part, adaptation to the pulmonary hypertension now present. | [
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10,003,246 | The role of neurological-developmental delay in childhood psychopathology. | [
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] |
10,003,247 | Human ecology and the mental health professions. | [
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10,003,248 | The clinical use of social-ecological concepts: the case of an adolescent girl. | [
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10,003,249 | The influence of family variables on an ecologically-based treatment program for emotionally disturbed children. | [
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10,003,250 | An ecological intervention with adolescents in low-income families. | [
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10,003,251 | Human ecology: primary prevention in pediatrics. | [
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10,003,252 | Labeling the learning disabled child: the social ecology of educational practice. | [
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10,003,253 | Family social support in crises: the special case of divorce. | [
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10,003,254 | Chronic schizophrenics in the community: are they able to report their social adjustment? | [
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10,003,255 | Evolution of an emergency room psychiatric staffing. | [
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10,003,256 | Delivery of social support: the social inoculation. | [
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10,003,257 | Endemic stress: the psychology of resignation and the politics of scarcity. | [
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10,003,258 | Expressive language deficits in preschool children and faulty development of the self: description and case study. | [
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10,003,259 | The value of touch in psychotherapy. | [
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] |
10,003,260 | Child abuse and neglect statutes: legal and clinical implications. | [
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10,003,261 | Experiencing child abuse: effects on emotional adjustment. | [
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10,003,262 | The development of children's enjoyment and comprehension of thematic riddles. | [
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10,003,263 | Presbycusis: the need for a clinical definition. | [
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10,003,264 | The term presbycusis is vague and needs specific signs and symptoms for its definition. Several types of presbycusis, depending on the type of lesion, have been proposed. This article suggests a working definition of "classic presbycusis," which may be defined as a syndrome involving (1) a bilaterally symmetric sensorineural hearing loss, (2) absent or partial recruitment, (3) negative noise history, and (4) poorer speech discrimination than indicated by pure tones (phonemic regression). | [
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10,003,265 | Comfortable speech listening levels: effects of competition and instruction. | [
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10,003,266 | This study was designed to investigate the effects of a background four=falker babble on the comfortable loudness level (CLL) for speech (California Consonant Test stimuli) using three sets of instructions. Three groups of twelve normal-hearing subjects each were tested using an adjustment psychophysical method. Each group received one of three sets of instructions, which were selected to sample the lower limit, most comfortable, or upper limit of the CLL range. Speech CLLs were initially obtained in quiet, then in the presence of four levels of competition (50 to 80 dB SPL, or 70 to 100 dB SPL), and finally in quiet again. Very similar means were found for the two quiet conditions for all instructions, indicating that the intervening four-talker conditions did not alter the final quiet CLL. The four-talker babble resulted in very substantial CLL shifts fro the lower limit instructions, although relatively little effect was observed on the upper limit of the CLL range. These differential effects were reflected as a systematic reduction in th CLL range with increasing competition levels. Whereas there was approximately 60-dB CLL range when the lower and upper limits were measured in quiet, introduction of the 80-dB SPL competition reduced this range to 16 dB. These data raise questions as to which instructions are most appropriate when CLLs are used to select and evaluate hearing aids, and how much, if any, background competition should be employed when making these measurements. | [
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10,003,267 | Cholesteatoma surgery at the otologic medical group: residual and recurrent disease. A report on 307 revision operations. | [
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10,003,268 | Auricularis posterior muscle biopsy. Technique, preparation and uses. | [
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10,003,269 | Abnormalities, congenital anomalies, and unusual anatomic variations of the endolymphatic sac and vestibular aqueduct: clinical, surgical, and radiographic correlations. Group 3, 4, and 5 abnormalities. | [
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] |
10,003,270 | ABR in eighth-nerve and brain-stem disorders. | [
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10,003,271 | Auditory brain-stem response (ABR) results are reported on three cases of acoustic tumors and two cases with brain-stem lesions. These cases highlight several considerations in the clinical use of ABR. The sensitivity of ABR to retrocochlear involvement in light of normal pure-tone hearing and cochlear hearing loss is shown in the first two cases. The third case shows the advantage of "contralateral" ABR testing and a unique effect of stimulus polarity. The use of an intensity function and high presentation rate procedures are shown to be helpful diagnostic procedures in case four. Case five shows bilateral ABR effects which correlate well with the degree of brain-stem involvement. In addition to the ABR data, audiologic, radiologic, and medical findings on these patients are also discussed. | [
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10,003,272 | Clinicopathologic studies in tympanosclerosis. | [
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] |
10,003,273 | Light-and electron-microscopic studies of the tissue from middle ears diagnosed as having tympanosclerosis, adhesive otitis media, postinflammatory ossicular fixation, and chronic otitis media revealed more or less similar findings of inflammatory response and healing. The histopathologic findings of "whitish sclerotic masses," especially around the ossicular chains, were due to fibrosis of submucosal connective tissue with hyalinization and calcification and/or metaplasia of mucosal epithelium. Longstanding and repeated undrained suppurative or nonsuppurative effusions would promote progressively more dense and avascular fibrous adhesions in the tympanum. The extensive fibrous changes in the tympanum would be a consequence of inadequate antibiotic therapy for middle ear inflammation and effusion. A new diagnostic term of tympanomastoidfibrosis is proposed to explain these clinical and histopathologic conditions as a replacement for the terms tympanosclerosis, adhesive otitis media, inflammatory ossicular fixation, and so on. | [
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10,003,275 | Four temporal bones of human newborns were studied with light and electron microscopy. In contrast to the adult human spiral ganglion as described by Kimura and coworkers, that of the newborn baby shows no myelination, either of the large ganglion cells or of the small. Whereas in adults the small ganglion cells contain neurofilaments or neurotubules, newborns have no cytoplasmic criteria by which to differentiate large and small neurons. Except for the small neurons, unmyelinated nerve fibers end on the surface of the ganglion cell or they penetrate into the cytoplasm. They form synaptic contacts. It is assumed that they belong to the efferent intraganglionic spiral bundle. | [
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] |
10,003,276 | Morphologic features of the normal and "pathologic" vestibular nerve of man. | [
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10,003,277 | The innervation of the outer hair cell system. | [
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10,003,278 | Ultrastructural evaluation of biochemical events of bone resorption in human chronic otitis media. | [
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10,003,279 | Bone resorption is a significant component of chronic inflammatory ear disease. Bone is a unique tissue requiring both demineralization and collagen degradation for breakdown. Mineral removal probably occurs prior to collagen destruction. A localized change in pH may be one of the mechanisms that induces demineralization. Localized accumulations of lysosomal acid hydrolases could provide the acidic environment necessary for mineral removal. The present study utilizes the electron microscope to localize the lysosomal enzyme acid phosphatase in specimens removed from patients with chronic otitis media. Areas of localized bone resorption exhibited mononuclear inflammatory cells attached to the resorption margin. These cells contained abundant acid phosphatase, as did isolated fibroblasts within the zone of inflammation at the resorption margin. Extra cellular acid phosphatase was seen in these areas. Within the bone, osteocytes adjacent to resorption displayed increased cytoplasmic organelle patterns and contained the acid phosphatase reaction. The localization of destructive enzymes in mononuclear inflammatory cells and osteocytes explains the bony destructive changes observed in human chronic otitis media in the absence of multinucleated osteoclasts. | [
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10,003,280 | Bone resorption in otospongiosis. | [
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10,003,281 | "Considerable interest has been raised in recent years concerning the basic mechanisms involved in bone destruction and rebuilding in the otospongiotic focus. Under general bone resorption the osteoclasts play a decisive role, but in otospongiotic tissue electron-microscopic and cytochemical studies have shown that osteoclasts alone are not responsible for the bone resorption. Mononuclear histiocytes found in the marrow spaces and in the surrounding bone of an otospongiotic focus together with osteocytes take active part in the resorption. Cytochemical studies of acid phosphatase activity have shown that hydrolases in the lysosomes are expelled into the surrounding tissue, resulting in its resorption. | [
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10,003,282 | Doctors' discussion. | [
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10,003,283 | The residency program in otolaryngology at Columbia-Presbyterian Medical Center. | [
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10,003,285 | Overview: the sex of the therapist. | [
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10,003,286 | Research studies about the relevance of therapist gender to assessment, duration of treatment, and satisfaction with treatment or its outcome provide no clear, replicable results salient to decision making. Psychoanalytic and other clinical writings deal with the impact of clinician gender on the course or outcome of psychotherapy. Effects appear to depend on many factors, including the type and goal of psychotherapy, the patient's developmental level, the early relationship with parents, and the nature of object relationships and specific conflictual areas, as well as the therapist' sensitivity and value system regarding gender issues. No specific conclusions as to optimal patient-therapist matches on the basis of therapist sex appear warranted. | [
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10,003,287 | Plasma imipramine concentrations in patients receiving concomitant fluphenazine decanoate. | [
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10,003,288 | Erythrocyte calmodulin in chronic schizophrenia. | [
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10,003,289 | Mania responsive to lecithin in a 13-year-old girl. | [
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10,003,290 | Sustaining treatment with the hospitalized patient who refuses treatment. | [
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10,003,291 | Pseudodementia in an elderly woman with schizophrenia. | [
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10,003,292 | Carbamazepine treatment of selected affectively disordered inpatients. | [
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10,003,293 | Concurrent use of theophylline and lithium in a patient with chronic obstructive lung disease and bipolar disorder. | [
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10,003,294 | DSM-III melancholia and the primary-secondary distinction: a comparison of concurrent validity by means of the dexamethasone suppression test. | [
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10,003,295 | Janusian thinking and Nobel prize laureates. | [
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10,003,296 | True and pseudo cholinesterases in depression. | [
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10,003,297 | Staff and inpatient perceptions of change mechanisms in group psychotherapy. | [
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10,003,298 | Fluctuating postdexamethasone cortisol levels in a patient with melancholia. | [
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10,003,299 | Institutional realities behind court decisions. | [
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