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10,003,000 | To compare the relative merits of conventional and axial RAO/LAO angiography, we performed biplane left ventricular (LV) cineangiograms in 36 patients in both the conventional 30-degree RAO/60-degree LAO projection and in the axial 45-degree RAO/60-degree LAO/25-degree cranial projection, in random sequence. LV volumes were calculated by a computerized system utilizing modification of the area-length method. Eng-diastolic volume, end-systolic volume, and ejection fraction correlated closely between the two projections (r = 0.93, 0.95, and 0.86, respectively). The axial 60-degree LAO view projected the LV apex inferiorly, the LV outflow tract superiorly, reduced LV foreshortening, and "uncovered" the LV outflow tract in all cases. Segmental wall motion abnormalities of the ventricular septum, apex, and posterior wall were better evaluated by the axial 60-degree LAO view in patients with regional asynergy in these zones. The 45-degree RAO, compared to the 30-degree RAO view, allowed a true tangential view of the mitral valve and provided a large "clear area" between the mitral valve and descending aorta, which improved the ability to quantify mitral regurgitation. Thus, axial oblique LV angiography improves evaluation of LV regional wall motion and mitral valve function without compromising LV volume quantitation. | [
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10,003,001 | High predictive accuracy for detection of left main coronary artery disease by antilog signal processing of two-dimensional echocardiographic images. | [
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10,003,002 | Two-dimensional echocardiography has been used to image the left main coronary artery. We have successfully imaged the left main coronary artery in 16 of 19 patients with left main coronary artery disease (LMCAD) and in 14 of 18 control patients using a dynamically focused 3-1/2 MHz experimental phased array sector scanner. Images were displayed with standard logarithmic compression grey scale allocation and with a modified antilog curve which enhances high intensity echoes. All of the 16 patients with LMCAD were identified from the antilog processed image. Only 1 of the 18 control patients had a false positive study. Modified antilog processed images provide high sensitivity (100%) and specificity (93%) for detecting LMCAD. This noninvasive technique could be used to screen patients for the presence or absence of LMCAD. | [
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] |
10,003,003 | Echographic-quantified severity of mitral anulus calcification: prognostic correlation to related hemodynamic, valvular, rhythm, and conduction abnormalities. | [
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] |
10,003,004 | Clinical and echocardiographic findings in 123 patients with mitral anulus calcification (MAC) were analyzed. In all patients M-mode echocardiography demonstrated a dense band of echoes posterior to the mitral valve, moving parallel and anterior to the left ventricular endocardium. Thirty-three per cent of patients were classified as having minimal to mild MAC (< 5 mm) and 67% had moderate to severe MAC (greater than or equal to 5 mm). There was a significant correlation between the degree of MAC to left atrial enlargement, congestive heart failure, aortic valve sclerosis, mitral regurgitation, atrial fibrillation, and AV-fascicular conduction defects. ECG evidence of conduction disturbances was significantly associated with MAC greater than or equal to t mm in width. The echocardiographic demonstration of MAC greater than or equal to 5 mm was significantly associated with the clinical implications known to occur with MAC; this echographic finding has important prognostic value in the evaluation of patients with mitral anulus calcification. | [
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10,003,005 | High prevalence of symptomatic bradyarrhythmias due to atrioventricular node-fascicular and sinus node-atrial disease in patients with mitral anular calcification. | [
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10,003,006 | Mitral anular calcification (MAC) is associated with high frequency of conduction defects. To delineate this association in patients with symptomatic bradyarrhythmias, 68 consecutive patients requiring pacemakers (group I) and 56 matched controls (group II) were studied. The patients comprised 41 men and 27 women, whose ages ranged from 24 to 92 years (mean 68). The control group consisted of 56 subjects without bradyarrhythmias, whose ages ranged from 30 to 86 years (mean 70); there were 36 men and 20 women. MAC was detected in 59 patients (87%) with symptomatic bradyarrhythmias compared with 8 subjects (14%) in the control group. In group I, 15 patients (22%) had complete atrioventricular block, 23 patients (34%) had atrial fibrillation with slow ventricular response, and 30 patients (44%) had intermittent sinus arrest. The incidence of MAC was similar among these subgroups (93%, 83%, and 87%, respectively). Thus the present study confirms the strong association of MAC with symptomatic bradyarrhythmias. | [
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10,003,007 | ECG synchronized computed tomography in clinical evaluation of total and regional cardiac motion: comparison of postmyocardial infarction to normal hearts by rapid sequential imaging. | [
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] |
10,003,008 | Computed tomograph (CT) of the heart was performed using the JEOL Dynamic Scanner, which provides CT cardiac images with minimal radiation and within a short period of time. ECG-synchronized CT was undertaken at various phases of the cardiac cycle every 0.04 second. Approximately 30 minutes of scanning was necessary to obtain a series of CT images of one complete cardiac cycle. In contract to 24 normal subjects, 38 patients with recent or remote myocardial infarction (MI) demonstrated hypokinetic, akinetic, or paradoxical movement of the ventricular segment corresponding to the MI sites predicted by ECG. The sequential cardiac area curve was useful in evaluating instantaneous changes of cardiac dimension, extent of ventricular contraction, and regional dyssynergy. ECG-synchronized CT studies using Somatom contrast dye enhancement in selected patients allowed sequential assessment of left ventricular cavity size and wall motion. | [
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10,003,009 | Clinical significance of isolated coronary bridges: benign and frequent condition involving the left anterior descending artery. | [
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10,003,010 | Two-dimensional echocardiographic features of submitral left ventricular aneurysm. | [
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10,003,011 | Walk-through angina phenomenon demonstrated by graded exercise radionuclide ventriculography: possible coronary spasm mechanisms. | [
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10,003,012 | Phonographic-echographic documentation of systolic honk in triscupid prolapse. | [
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10,003,013 | Two-dimensional echocardiographic detection of staphylococcal vegetation attached to calcified mitral anulus. | [
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10,003,014 | Total anomalous pulmonary venous connection: survival for 62 years without surgical intervention. | [
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10,003,015 | High-speed echophonocardiograhic detection of tricuspid valve prolapse in mitral valve prolapse with discrepancy in onset of systolic murmur. | [
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10,003,016 | ECG changes associated with iatrogenic left pneumothorax simulating anterior myocardial infarction. | [
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10,003,017 | Verapamil effects on retrograde conduction in supraventricular tachycardia therapy. | [
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10,003,018 | Possible coronary spasm rebound to abrupt nifedipine withdrawal. | [
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10,003,019 | Ischemic ECG changes with initial nifedipine therapy of severe hypertension. | [
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10,003,020 | Paroxysmal nocturnal dyspnea in CHF: mechanisms and aminophylline therapy. | [
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] |
10,003,021 | The pharmacist and the pediatric patient. | [
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10,003,022 | Prehospital cardiac care: does it make a difference? | [
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10,003,023 | Childhood enuresis. Treating the habitual bed wetter. | [
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10,003,024 | Child health research today ... and tomorrow. | [
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10,003,025 | Wellness: a new concept in health care. | [
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10,003,026 | A strategy for marketing pharmacy services. | [
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] |
10,003,028 | Dimethyl terephthalate. | [
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] |
10,003,029 | Hexadiene. | [
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10,003,030 | Piperidine. | [
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] |
10,003,031 | Health matrix--toxic waste isolation. | [
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10,003,032 | Protecting workers who clean up hazardous waste sites. | [
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10,003,033 | On April 21, 1980, an explosion and fire among the 40 000 drums of unlabeled chemical wastes at the former site of Chemical Control Corporation in Elizabeth, New Jersey, attracted national attention and raised serious concern about the health and safety of workers who would be called upon to clean up the disaster site. Evaluation of workers' exposure during clean up operation and an assessment of the level of respiratory protection needed were necessary. NIOSH conducted 8 days of air monitoring. The chemicals of concern were organic vapors, metals, pesticides, polychlorinated biphenyls, cyanide compounds, and dioxins (TCDD). No excessive exposure to chemical substances by inhalation was found. However, continuous use of respiratory protective equipment and other personal protective devices was necessary because of frequent drum ruptures. | [
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10,003,034 | Human exposure to sulfur dioxide and ozone in a high temperature-humidity environment. | [
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10,003,035 | In order to examine the role of high temperature and humidity in the possible synergistic action of ozone and sulfur dioxide on human pulmonary function previously reported by some investigators and repudiated by others, we randomly exposed eight healthy young male nonsmokers to filtered air, 0.4 ppm SO2, 0.4 ppm O3, and 0.4 ppm SO2 plus 0.4 ppm O3 at 35 degrees C--85% rh for 2 hours. Subjects exercised for 15 minutes of each half hour at a workload sufficient to elicit a minute ventilation of 30 liters (BTPS). Pulmonary function tests were performed prior to, during, and following exposure. Observed alterations in pulmonary functions in the SO2 + O3 exposure reflected the changes occurring during the O3 exposure, clearly indicating that no synergistic effects related to the additional presence of SO2 were evident in this study. We considered factors suggested as causes for a potential synergism in comparing the conflicting studies on O3 and SO2, and suggest that factors other than temperature-humidity and/or sulfate aerosol production must be sought. | [
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10,003,036 | Comparison of hearing loss in the first year of employment in workers assigned to noise-hazard and non-noise-hazard areas at the state prison industries. | [
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10,003,037 | Experience in hearing loss at Utah State Prison in noise-hazard and non-noise-hazard areas suggested a matched-pair study of these two groups. The study of noise induced hearing loss and its relation to age has become more and more of scientific and economic interest in the past few years. Since the creation of OSHA and the enforcement of its standards, great strides have been undertaken at USP to protect the worker in noise areas, with both noise abatement and hearing protection. The need became apparent for a measurement of this progress and a comparison on hearing loss between the two worker groups. A retrospective chart study was designed utilizing one hundred pairs of workers matched for age, sex and initial hearing loss. The results suggest no significant difference between the two groups during one year of exposure. | [
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10,003,038 | Exposure to isophorone and other organic solvents in a screen printing plant. | [
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] |
10,003,039 | A study was conducted in a screen printing plant to determine the exposure of workers to isophorone and other organic solvents. One hundred twenty-four charcoal tube samples were collected from both workers breathing zones and various workplace areas. Sampling times were 50-90 minutes. Maximum mean TWACs of isophorone and cyclohexanone were 23 +/- 5.4 ppm and 28 +/- 5 ppm, respectively, at the breathing zones of printing press workers. Exposure levels for other organic vapors such as cellosolve acetate, butyl acetate, xylenes, diacetone alchohol, and petroleum distillate are also presented. Mean TWACs of personal samples were generally higher than area samples due to proximity of the solvent evaporating surfaces to the workers breathing zones. Mean TWACs for the individual organic vapors did not exceed OSHA Limits. However, the sum of (TWAC/TLV) ratios of organic vapors with additive health effects exceeded unity at the breathing zones of workers handling inks and solvents. Actual 8-hour worker exposures were assumed to be lower because workers were exposed to lower concentrations (about 9/10 of the additive TLVs) in the plant's general atmosphere during non-active periods of the work shift. Recommendations for improvement of working conditions and reduction of exposure levels are made. | [
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10,003,040 | Early evaluation of potential worker exposure problems associated with the Claus-type sulfur recovery process. | [
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10,003,041 | Early evaluation of process plants, such as the Claus-type SRU (sulfur recovery unit), in the design stage not only minimizes worker exposure to toxic chemicals and noise, but also reduces costs for retrofit engineering controls. The Claus-type SRU converts the hydrogen sulfide in refinery acid gas into elemental sulfur. In the process, the SRU handles toxic gases containing high concentrations of H2S, SO2, and other sulfur compounds. These gases can be emitted into the worker's breathing zone during start-ups, shutdowns, routine operations, emergencies, and turnarounds. This paper describes the Claus-type sulfur recovery process, the potential sources of worker exposure to toxic chemicals and noise, and the engineering controls that should be adopted at the plant design stage to minimize the risks of worker exposure. Engineering controls include improved pump seals and a choice of sample configurations based on the physical form and concentration of H2S in the process lines. | [
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10,003,042 | A comparative study of aerosol deposition in different lung models. | [
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10,003,043 | Theoretical calculations are made on total and regional deposition of inhaled particles in the human respiratory system based upon various current lung models. It is found that although total deposition does not vary appreciably from model to model, considerably large differences are present in regional deposition. Deposition profiles along the airways from different models also show very different patterns. These differences can be explained in terms of airway dimensions and the number of structures in different models. Extension to explain intersubject variability is also made. | [
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] |
10,003,044 | Six month inhalation toxicity of fluomine dust. | [
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] |
10,003,045 | Fluomine is a cobalt chelate of interest in life support systems of high altitude aircraft. Rats, mice, guinea pigs and dogs were exposed to fluomine particles for a six month period on an industrial-type schedule. Chronic exposure of the dust caused a statistically significant decrease in the mean body weights of the test rats when compared to their respective control group. The dust had irritative effects on the respiratory systems of rats and dogs at the highest exposure level. A concentration of 0.1 mg/m3 is a suggested threshold limit at or below which no serious effects should occur. | [
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10,003,046 | A rapid method of determining the respiratory uptake of radionuclides of varying aerosol size. | [
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10,003,047 | Giant lymph node hyperplasia involving the thymus with associated nephrotic syndrome and myelofibrosis. | [
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10,003,048 | Giant lymph node hyperplasia (GLH) is an unusual form of benign lymphoid hyperplasia which, although it often occurs in the mediastinum, has not previously been reported to involve the thymus. In this report, a case of GLH with involvement of the thymus and with associated nephrotic syndrome and myelofibrosis is presented. The significance of the association of these conditions with GLH is discussed, including the possibility that some or all of the patient's abnormalities may have been related via an abnormal immune mechanism. | [
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10,003,049 | Cystic parathyroid gland hyperplasia--hyperparathyroidism presenting as a neck mass. | [
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10,003,050 | Hyperparathyroidism may occasionally present as a neck mass resulting from cystic change in a parathyroid adenoma. We report an unusual instance of hyperparathyroidism presenting as a palpable, but asymptomatic hyperplastic parathyroid gland cyst. We conclude that hyperplastic parathyroid glands may undergo cystic degeneration resulting in a palpable neck mass; and that all functional parathyroid gland cysts are not necessarily adenomas. Therefore, during parathyroidectomy procedures, biopsy material from at least one additional parathyroid gland should be obtained. | [
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10,003,051 | Who said it first? | [
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10,003,053 | Microcomputer "real time" capability questioned. | [
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10,003,054 | Not the first. | [
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10,003,055 | The diagnostic value of flow cytometric DNA measurements in selected disorders of the human thyroid. | [
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10,003,056 | A flow cytometric (FCM) analysis of biopsies from 19 patients with thyroid lesions (Hashimoto's thyroiditis, hyperplastic goiter, colloid and adenomatous nodular goiter, follicular adenoma, follicular carcinoma, anaplastic carcinoma) was performed to evaluate the relevance of such results for the individual diagnosis and prognosis and prognosis of such diseases. All cases of Hashimoto's thyroiditis, the colloid nodular goiters, and the hyperplastic goiter had a unimodal diploid pattern, while the anaplastic carcinomas were aneuploid. These lesions are, however, easily diagnosed on morphological grounds and their FCM classification would only be redundant. Follicular adenomas and follicular carcinomas may be either unimodal diploid or aneuploid, and our single case of adenomatous colloid goiter showed a bimodal DNA distribution. This means that a diploid modal DNA content in a follicular tumor does not rule out malignancy, while aneuploidy is not an unequivocal sign on malignancy. The evaluation of the percentage of cells in S-phase did not seem to contribute valuable information for the individual diagnosis of malignancy within the group of thyroid lesions studied. Our study indicates a rather limited clinical value of FCM measurements of DNA in the individual case of thyroid disease. | [
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10,003,057 | A lyophilized human reference plasma for coagulation factors. Evidence for stability of factors I, II, V, and VII through XII. | [
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10,003,058 | Results are reported of a one-year study on the stability of a lyophilized normal human reference plasma, originally standardized for eight clotting factor activities against a freshly prepared pool of citrated, platelet-poor normal human plasma. The stability of any particular coagulant activity in this reagent was represented mathematically as a function of the observed clotting times obtained under specific assay conditions, where any observed change in the clotting times over the trial period was taken to reflect a change in the stability of the reference plasma. Taking into consideration estimates of variability contributed by different donors of factor-deficient substrata-plasma, different lots of substrate from the same donor, different technologists, and certain age-of-substrate lot trends, there was no statistically significant change in functional activity for Factors V and VII through XII in the reagent when it was stored unreconstituted below -25C. By less rigorous criteria, both clottable fibrinogen (Factor I) and the thrombin-forming potential of prothrombin (Factor II) also were stable during this same period. Based on these results, it was concluded that when suitably prepared, lyophilized human plasma can be used as a stable, secondary standard reference for the assay of coagulation factors. | [
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10,003,059 | Predictability of immunologic phenotype by morphologic criteria in diffuse aggressive non-Hodgkin's lymphomas. | [
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] |
10,003,060 | Diffuse aggressive non-Hodgkin's lymphomas are immunologically and morphologically heterogeneous. Morphologic subclassifications have been proposed with a presumptive relationship to immunologic phenotype. Six histologic types were studied, four of presumed follicular origin (large cleaved, large non-cleaved, mixed follicular center cell, and blastic) and two of presumed nonfollicular origin (pleomorphic pyroninophilic and pleomorphic convoluted). Two of these follicular subtypes were found to be associated with the frequent presence of B-cell markers; large non-cleaved, six of seven; and blastic, four of six. However, four of nine T-cell lymphomas were misclassified as lesions of follicular center cell type, indicating the difficulty of distinguishing some convoluted cells of T-cell lymphoma from irregularly cleaved cells of follicular lymphoma. Pleomorphic pyroninophilic or B-immunoblastic morphology was associated with B-cell markers in only two of six cases; two additional cases had T-cell markers, one had histiocytic markers and in one case, no markers were demonstrable. Thus, this morphology may reflect a common pathway of transformed lymphoid cells. Some cases of T-cell origin could be recognized by the striking pleomorphic convoluted histology (three of five cases) but morphologic overlap with pleomorphic B-cell tumors, particularly transformed nodular lymphomas, posed a problem. This histopathologic subclassification correctly predicted immunologic phenotype in only 61% of cases, suggesting that in diffuse non-Hodgkin's lymphomas, histologic appearance alone may not be a reliable indicator of immunologic surface markers. | [
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10,003,061 | Statement from the Third Quadrennial International Symposium on Quantities and Units in Clinical Medicine--Paris, November 14-15, 1980. | [
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10,003,062 | Serum ferritin levels in celiac disease. | [
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10,003,063 | Of the various common assayed parameters of iron metabolism, serum ferritin levels are the most discriminatory in distinguishing between non-treated celiac disease and other gastrointestinal disorders in the pediatric age group. Patients on normal diets usually have very low ferritin levels that increase at an average rate of 1 microgram/1/month when placed on a gluten-free diet. When the patient returns to a normal diet, however, ferritin levels decrease rapidly at an average rate of about 4 microgram/1/month. There is a relationship between abnormal intestinal changes and low ferritin levels in celiac disease with improvement in both when the patient is on a gluten-free diet. It is suggested that serial blood ferritin evaluations together with the leukocyte migration inhibition factor production assay should eliminate the need for invasive intestinal biopsies for the confirmation and possible follow-up to response to treatment. | [
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10,003,064 | Vitamin E does not modify HDL-cholesterol. | [
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] |
10,003,065 | Vitamin E has been reported to increase serum high-density lipoprotein (HDL) cholesterol. Given the known inverse relationship between HDL-cholesterol and risk of developing coronary artery disease, these preliminary results require verification or refutation. In the present study, 39 volunteers were given 600 U of vitamin E daily for 30 days. Serum vitamin E, cholesterol, HDL-cholesterol, and triglycerides were measured at appropriate intervals. No significant change in serum HDL-cholesterol with vitamin E therapy could be documented. | [
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10,003,066 | Rapid processing of biopsy specimens for examination by electron microscopy. | [
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10,003,067 | A rapid method for embedding biopsies and other small specimens for examination by electron microscopy is described. This method is based on an embedding medium consisting of vinyl cyclohexane dioxide and cyanoacrylate which infiltrates into small specimens and polymerizes to form a cured specimen block within 15 minutes. Fixation, dehydration, infiltration and curing of specimens are all accomplished with 1 hour. The embedded specimens are relatively easy to section, stain by commonly employed electron-dense stains and are very stable under the electron beam. All specimens studied including blood, bacteria, and biopsy samples retained the salient ultrastructural features commonly preserved during lengthy methods of embedding. This method is designed for diagnostic laboratories that require rapid results. | [
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10,003,068 | Sarcoidosis in young children. | [
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10,003,069 | Twenty-eight cases of sarcoidosis in children 4 years of age or younger have been reported in the literature, including the case presented herein. These patients may display a distinct aspect of this disease. Half of them are younger than 1 year and all but two are whit. Clinically, they are different from the older children: they lack pulmonary disease, and they predominantly have uveitis, arthritis, and skin rash. The natural history of the disease not only involves chronic arthritis, but has the potential for renal disease secondary to hypercalciuria. Use of adrenocorticosteroids may be effective in these situations, as well as for eye involvement. | [
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10,003,070 | Sickle cell-Hb Lepore Boston syndrome. Uncommon differential diagnosis to homozygous sickle cell disease. | [
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10,003,071 | Two siblings assumed on the basis of clinical and hematological evidence to have homozygous sickle cell (SS) disease were found to have a mother without sickle hemoglobin. Subsequent investigation and hemoglobin structural studies indicated the diagnosis to be sickle cell-Hb Lepore Boston syndrome. This syndrome generally manifests clinically significant sickle cell disease, and this genotype should be borne in mind in apparent SS disease where a parent without sickle hemoglobin in discovered. | [
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10,003,072 | Prune belly syndrome in two siblings and a first cousin. Possible genetic implications. | [
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10,003,073 | Fractures in the first year of life. A diagnostic dilemma. | [
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10,003,074 | Thirty-four patients with 55 fractures in the first year of life were studied. There were 189 patients with 21 skull fractures and 16 patients with 19 extremity fractures. Extremity fractures occurred at a significantly younger age than did skull fractures. Cause was defined as accidental in 15 patients (44%) and nonaccidental (child abuse) in 19 patients (56%), representing a greater incidence of accidental cause than previous reports indicated in this age group. There were no significant differences between the two groups with regard to mean age, percentage of girls, number of fractures per patient, and distribution of fractures. Eight patients had notable constitutional abnormalities contributing to the causes of their fractures. There was no difference between this group and normal patients with regard to mean age, percentage of girls, distribution of fractures, and number of fractures per patient. | [
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10,003,075 | Nonconvulsive epileptiform activity appearing as ataxia. | [
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10,003,076 | Ataxia may be the result of otherwise silent epileptiform activity. We studied three patients, between 3 and 5 years of age, whose initial complaint was unsteadiness of gait. Each one of the patients had an epileptiform EEG with bursts of slow spike and wave activity. Each had normal results of diagnostic studies for other causes of ataxia. Specifically, none had anticonvulsant drug levels in the toxic range. Modification of the anticonvulsant regimen resulted in dramatic clinical and EEG improvement. Nonconvulsive epileptiform activity has been called pseudoataxia in the scant literature on this subject. This process should be considered in the evaluation of ataxia in children. | [
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10,003,077 | Cefaclor therapy twice daily for acute otitis media. Controlled comparative study of twice-daily vs thrice-daily dose schedule. | [
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10,003,078 | Breast-feeding and infant health in a rural US community. | [
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10,003,079 | The medical history for the first year of life of 106 infants in a rural community was reviewed. During the first month of life, a significant difference was found in the number of office visits for illness between breast-fed infants and infants who were bottle-fed from birth. For the first 6 months of life, breast-fed infants with and without bottle supplements had significantly fewer months with illness than bottle-fed infants, regardless of prior exposure to breast milk. Demographic data indicated no appreciable differences between feeding groups. It is concluded that breast-feeding offers a protective advantage against illness. | [
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10,003,080 | Penicillin-resistant Streptococcus constellatus as a cause of endocarditis. | [
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] |
10,003,081 | Endocarditis in a 2-year-old child was caused by a penicillin-resistant Streptococcus constellatus. Viridans streptococci in general and those associated with endocarditis in particular are usually believed to be penicillin sensitive. Although the patient did not receive prophylactic antibiotics, the child had recently been treated with an oral penicillin. Penicillin-resistant viridans streptococci are usually sensitive to the synergistic effects of penicillin and an aminoglycoside, but this organism was not. Clindamycin was ultimately shown to demonstrate admirable bactericidal activity against this patient's S constellatus. | [
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10,003,082 | Fluoride supplementation in Harris County, Texas. | [
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10,003,083 | We sent questionnaires to 421 physicians in Harris County, Texas, to determine the use of oral fluoride supplementation. The response rate was 56%. Although 95% of the physicians practice in fluoride-deficient areas (less than 0.7 ppm), 36% of those responding stated that the fluoride content of the water was adequate; 25% were unsure. Of those who thought that the fluoride content was adequate, 79% stated that the actual fluoride content was less than 0.7 ppm or were unsure. Only 35% of the responding physicians prescribed fluoride, only 45% knew the correct dose. Only 50% of the responders made routine dental referrals in the 3- and 4-year age group. More physician education is needed to ensure oral fluoride supplementation in communities with inadequately fluoridated water supplies. | [
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] |
10,003,084 | Radiological case of the month. Neonatal fracture of the femur: iatrogenic? | [
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10,003,085 | Epididymal sarcoidosis in a prepubertal child. | [
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] |
10,003,086 | Medication bezoar in a neonate. | [
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10,003,087 | Apnea associated with theophylline withdrawal in a term neonate. | [
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10,003,088 | Intussusception in a premature infant simulating neonatal necrotizing enterocolitis. | [
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10,003,089 | Zinc deficiency in a premature infant fed exclusively human milk. | [
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10,003,090 | Myositis with Kawasaki's disease. | [
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10,003,091 | Survival after massive small intestinal resection in a neonate. | [
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10,003,093 | Smoking and pregnancy. | [
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] |
10,003,094 | Should dead cases be matched to dead controls? | [
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10,003,095 | Quantitated effects of carbon disulfide exposure, elevated blood pressure and aging on coronary mortality. | [
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] |
10,003,096 | Risk function analysis was performed in order to clarify the relationship between coronary heart disease death rate and occupational carbon disulfide exposure along with two other important risk factors, elevated diastolic blood pressure and older age, in a data set obtained from a 10-year prospective follow-up of coronary mortality in two cohorts of over 340 male industrial workers in Finland. The sole effect of carbon disulfide on the coronary mortality was statistically significant (relative risk = 2.3), and it was largely independent of the level of the other two risk factors. Log-linear models were fitted to predict coronary heart disease deaths. The analysis identified the dual role of raised blood pressure in the potential mechanism of coronary death. Relative risks ranging up to 48 were obtained for the joint non-synergistic effect of these three factors in the exposed group compared to a subgroup of nonexposed, 40-year-old normotensive men. The effect of carbon disulfide exposure on the risk of coronary death, while clearly distinguishable from the effect of hypertension and aging, stayed subordinate to them, but nevertheless remained an important risk element in the work environment. | [
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10,003,097 | A two stage design for the study of the relationship between a rare exposure and a rare disease. | [
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10,003,098 | Studies of the relationship between a rare disease and a rare exposure to a risk factor require a very large sample size to obtain reasonable estimates of risk. The cost of such studies is often prohibitive. This paper presents a less costly, two stage approach. Disease and exposure status are ascertained on a large sample in the first stage, but covariate data are collected on only a subsample in the second stage. This subsample is chosen by separately sampling from the four groups based on disease and exposure status (the diseased and exposed, the diseased and unexposed, etc.). The efficiency of this design is achieved by sampling a large proportion (or all) of the subjects from the small groups and a smaller proportion of those from the large groups. An example of a method of analyzing data from this study design, based on weighted least squares techniques, is given. Application of this new design to studies not involving a rare disease and rare exposure are discussed. | [
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10,003,099 | Models of varying parametric form in case-referent studies. | [
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