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10,004,900 | In vivo studies have suggested that serotonin (5HT) influences anterior pituitary function at the hypothalamic level. The present in vitro study investigated the possibility that 5HT may act directly on the anterior pituitary. The high affinity uptake of [3H]5HT into adult rat anterior pituitary tissue was examined in ... | [
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10,004,901 | Effects of congenital hypothyroidism and partial and complete food deprivation on phenolic and tyrosyl ring iodothyronine deiodination in rat brain. | [
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10,004,902 | Guanyl nucleotides participate in the beta-adrenergic stimulation of adenylate cyclase activity in the intermediate lobe of the rat pituitary gland. | [
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10,004,903 | The existence of a stimulatory guanyl nucleotide component in the intermediate lobe of the rat pituitary gland (IL) is supported by the observations that: 1) GTP was required for beta-adrenergic stimulation of adenylate cyclase activity in homogenates of IL tissue; 2) GTP, in the absence of a beta-adrenergic agonist, m... | [
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10,004,904 | D-2 dopamine receptor-mediated inhibition of adenylate cyclase activity in the intermediate lobe of the rat pituitary gland requires guanosine 5'-triphosphate. | [
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10,004,905 | After treatment with cholera toxin, homogenates of intact intermediate lobe (IL) tissue of rat pituitary gland synthesized more cAMP than did homogenates of untreated IL tissue, and only in the presence of GTP did dopamine or apomorphine diminish the elevated adenylate cyclase activity in homogenates of cholera toxin-t... | [
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10,004,906 | Effect of pinealectomy on fatty acid composition of rat brain myelin. | [
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10,004,907 | To determine whether the previously demonstrated decrease in rat brian myelin after pinealectomy is associated with an abnormality in myelin composition, 92 rat pups were subjected either to pinealectomy or sham-pinealectomy at 4 days of age. These animals, reared in diurnal lighting, were killed at 40 days of age, and... | [
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10,004,908 | Influence of prolactin-producing pituitary grafts on the in vivo uptake, distribution, and disappearance of [3H]testosterone and [3H]dihydrotestosterone by the rat prostate lobes. | [
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10,004,909 | Light exposure reduces and pinealectomy virtually stops urinary excretion of 6-hydroxymelatonin by rhesus monkeys. | [
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10,004,910 | The major metabolite of the pineal hormone melatonin, conjugated 6-hydroxymelatonin, was hydrolyzed, separated from the urine of rhesus monkeys, and assayed mass spectrometrically. The daily excretion pattern reflected pineal melatonin synthetic activity, being 5- to 16-fold higher at night than during the day. Progres... | [
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10,004,911 | Oesophagitis in Italian and Hungarian asymptomatic subjects. | [
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10,004,912 | It is known that chronic inflammatory phenomena of the gastric mucosa fairly often occur in asymptomatic subjects. Starting from this fact, the authors decided to investigate possible non-symptomatic oesophageal inflammatory lesions referable to oesophagitis and any other digestive and/or systemic pathology. Furthermor... | [
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10,004,913 | Healing and recurrence of duodenal ulcers in relation to the acid-secreting area. | [
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10,004,914 | The relation of the gastric acid-secreting area to the healing and recurrence of duodenal ulcers was examined in 67 patients with duodenal ulcers. Studies were made by the endoscopic Congo red test developed at this institute. Results indicate a close correlation between the healing and recurrence of duodenal ulcers, a... | [
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10,004,915 | Effectiveness of the small-diameter panendoscope in diagnosing cancers of the upper gastrointestinal tract. | [
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10,004,916 | Endoscopic retrograde cholangiography in a case of biliary pseudocyst. | [
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10,004,917 | Successful endoscopic removal of a common bile duct foreign body. | [
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10,004,918 | Adenocarcinoma occurring in a hyperplastic (metaplastic) polyp of the colon. | [
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10,004,919 | A case of adenocarcinoma occurring in a hyperplastic (metaplastic) polyp of the colon is presented. The polyp, two cm in diameter, was located in the transverse colon of a 45-year-old male patient, and was removed endoscopically. From the periphery to the centre, the polyp showed epithelial changes progressing from hyp... | [
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10,004,920 | Collagenous colitis. | [
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10,004,921 | Incidental procurement of gastric biopsy. | [
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10,004,922 | "Ebb phenomenon" -- diagnosis of submucosal diffuse invasion of esophageal cancer. | [
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10,004,923 | The discovery of the "ebb phenomenon" in 1973 made it possible to detect submucosal diffuse invasion endoscopically. In 23 cases out of 74 cases, submucosal diffuse invasion was recognized. In 18 cases, submucosal diffuse invasion was recognized. In 18 cases, submucosal diffuse invasion was less than 30 mm from the mar... | [
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10,004,924 | A quantifiable bleeding gastric ulcer in dogs for assessing the neodymium Yag laser. | [
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10,004,925 | Changes in intelligence following temporal lobectomy: relationship to EEG activity, seizure relief, and pathology. | [
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10,004,926 | Pre- and posttemporal lobectomy measures of intelligence and memory in 36 patients with medically refractory complex partial seizures were compared with (1) various aspects of presurgical ictal and interictal EEG activity derived from surface and deep electrodes, (2) postlobectomy seizure relief, and (3) pathological f... | [
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10,004,927 | Preliminary study of the effects of carbamazepine on congenital orofacial defects in offspring of A/J mice. | [
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10,004,928 | Carbamazepine (CBZ; Tegretol) is an effective anticonvulsant drug. We assessed putative CBZ teratogenicity in a sensitive animal model, the A/J mouse. Plasma CBZ levels were determined by gas-liquid chromatography. To achieve the accepted human plasma therapeutic range (TR) of CBZ (8-12 micrograms/ml), up to a 6X human... | [
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10,004,929 | Feline generalized epilepsy induced by tranexamic acid (AMCA). | [
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10,004,930 | Epileptic activities induced by topical application of tranexamic acid (AMCA) and penicillin to the cortex of 12 cats in acute experiments were compared. Both substances when diffusely applied on a wide cortical area of both hemispheres at very low concentration produced an EEG pattern consisting of spike-wave bursts s... | [
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10,004,931 | Clinical evolution and prognosis of childhood epilepsies. | [
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10,004,932 | Five-hundred twelve epileptic children were followed longitudinally for several years. The 2- and 4-year remission statuses at the latest examination were 50.6 and 44.2%, respectively. Dividing our sample into groups showing onset of seizures in infancy or at 2-3, 4-7, 8-10, or 11-14 years, the remission rates were as ... | [
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10,004,933 | Expression of two late adenovirus genes is altered by introducing antibodies against ribonucleoprotein into living HeLa cells. | [
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10,004,934 | Role of free oxaloacetate in ketogenesis. Derivation from the direct measurement of mitochondrial [3-hydroxybutyrate]/[acetoacetate] ratio in hepatocytes. | [
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10,004,935 | Kinetics of coupled reactions catalyzed by aspartate aminotransferase and glutamate dehydrogenase. | [
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10,004,936 | Liver mitochondrial aspartate aminotransferase and glutamate dehydrogenase catalyze following sequence of reactions: see formula in text. In the presence of a slight excess of dehydrogenase, the time course of NADPH oxidation resulting from the overall reaction goes through a lag phase and reaches a linear phase. The s... | [
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0.00008343492663698271,
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10,004,937 | 31P-NMR analysis of synaptic vesicles. Status of ATP and internal pH. | [
-0.0327669195830822,
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0.009573720395565033,
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10,004,938 | The status of ATP in cholinergic synaptic vesicles from electric organ of Torpedo marmorata has been studied by 31P-NMR. In isolated vesicles, ATP was found to be the only major phosphate-containing constituent. The chemical shifts and the linewidths of the P gamma and P beta resonances are different from those of unco... | [
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0.05... |
10,004,939 | Membranes of protein bodies. I. Isolation from cotyledons of germinating cucumber seeds. | [
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... |
10,004,940 | Protein bodies were prepared from cotyledons of germinating seeds of cucumber (Cucumis sativus) in different ways: the organelles either obtained from protoplasts by lysis or from cotyledons by mechanical disintegration were separated on sucrose-density gradients. In addition, a non-aqueous procedure was employed to is... | [
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10,004,941 | Membranes of protein bodies. II. Detection and partial characterization of membrane glycoproteins. | [
-0.039415307343006134,
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0.065... |
10,004,942 | The synthesis of organelle proteins was studied in cotyledons of Cucumis sativus. Protein constituents of protein-body membranes were shown to be synthesized and assembled, at a stage characterized by mobilization of the storage globulin. Besides L-[35S]methionine various labelled hexoses were incorporated into protein... | [
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... |
10,004,943 | Isolation and characterization of a lipid-embedded domain of the acetylcholine receptor from Torpedo californica. | [
-0.016240425407886505,
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0.03... |
10,004,944 | A structural study of filamin, a high-molecular-weight actin-binding protein from chicken gizzard. | [
-0.0797850713133812,
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0.1334457546... |
10,004,945 | Oligomeric species in glycerol-cycled bovine-brain microtubule protein. Analytical ultracentrifugal characterisation. | [
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10,004,946 | Conformational changes induced by hapten in pig antibodies to the dinitrophenyl group. Analysis by temperature-perturbation and solvent-perturbation spectroscopy. | [
-0.021767010912299156,
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10,004,947 | Pig antibodies to the dinitrophenyl group and fragments derived from them by limited proteolysis were studied by temperature-perturbation and solvent-perturbation spectroscopy with particular attention to differences between the number of perturbed chromophores in free antibodies and in antibody-hapten complexes. The p... | [
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0.06264742... |
10,004,948 | Hemoglobin expression in clones of K562 cell line. | [
-0.027776598930358887,
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-0.06... |
10,004,949 | The K562 cell line was cloned by dilution and the pattern of hemoglobin (Hb) production was analyzed in the clones thus obtained. The pattern of hemoglobin synthesis was different from one clone to another. According to the Hb phenotype the clones were classified in three main groups; group I no detectable Hb; group II... | [
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... |
10,004,950 | Carbon-13 nuclear-magnetic-resonance studies of glucose catabolism by Trypanosoma brucei gambiense. | [
-0.005333101376891136,
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0.040... |
10,004,951 | 13C Nuclear magnetic resonance studies have been performed in vivo on Trypanosoma brucei gambiense. The glycolytic pathway has been observed using specifically labelled 13C-enriched glucose and it has been ascertained that there is, under anaerobic conditions, predominant incorporation of C-1 of glucose into glycerol w... | [
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0.027194315567612648,
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... |
10,004,952 | A special education course with pediatric components. | [
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0.02863152138888836,
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0.082... |
10,004,953 | Psychiatric hospitalization of adolescents and successful mainstream reentry. | [
0.013772890903055668,
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0.09780409187078476,
0.046813253313302994,
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0.01289... |
10,004,954 | Strategies to increase parent participation in IEP conferences. | [
0.05581504479050636,
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0.016... |
10,004,955 | Expanded use of captioned films for learning disabled students. | [
0.010134718380868435,
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0.01537898276001215,
0.05510... |
10,004,956 | Effects of the label "institutionalized" vs. "regular school student" on teacher expectations. | [
0.0933084562420845,
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0.03798085... |
10,004,957 | Regular classroom teacher involvement in the development and utilization of IEP's. | [
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0.025136... |
10,004,958 | Comprehension scores of learning disabled high school students on aurally presented content. | [
0.09682238847017288,
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0.009197280742228031,
0.01266... |
10,004,959 | Systolic time intervals during spironolactone treatment of digitalized and non-digitalized patients with ischaemic heart disease. | [
0.030498137697577477,
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0.0... |
10,004,960 | The effect of spironolactone on cardiac contractility indices was studied by externally recording systolic time intervals in four digitalized and four non-digitalized patients with ischaemic heart disease. A negative inotropic effect was found after spironolactone 100mg b.i.d. in all eight patients, as measured by an i... | [
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0.... |
10,004,961 | Response of blood pressure and plasma norepinephrine to propranolol, metoprolol and clonidine during isometric and dynamic exercise in hypertensive patients. | [
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0... |
10,004,962 | The effects of metropolol (beta 1-selective), propranolol (nonselective) and clonidine (central alpha-stimulant) on plasma norepinephrine, blood pressure and heart rate were assessed at rest, during isometric work and dynamic exercise in 15 patients with moderate hypertension. Metroprolol resulted in a lower diastolic ... | [
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0.02323586866259575,
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0.... |
10,004,963 | Quinidine-digoxin interaction: evidence for involvement of an extrarenal mechanism. | [
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0.043... |
10,004,964 | The influence of quinidine 750mg per day for one week on serum digoxin concentration (SDC) was evaluated in digitalized anuric patients on chronic haemodialysis. During quinidine administration the SDC increased markedly, from 0.84 +/- 0.37 to 1.58 +/- 0.72 ng/ml (p less than 0.01), a comparable effect ot that reported... | [
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0.0... |
10,004,965 | The effect of food on the pharmacokinetics and pharmacodynamics of tolmesoxide in essential hypertensives. | [
-0.043836407363414764,
-0.03461576625704765,
-0.09346859902143478,
0.11585642397403717,
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0.006593895610421896,
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-0.03179768845438957,
0.00466... |
10,004,966 | Tolmesoxide is a new, direct-acting vasodilator drug for use in the management of both hypertension and cardiac failure. In 6 essential hypertensives inadequately controlled by combined beta-blocker and diuretic therapy (average supine blood pressure 178/103 mmHg) the addition of tolmesoxide (300-900mg daily) was assoc... | [
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0.00... |
10,004,967 | Kinetics of furosemide in children with chronic renal failure undergoing regular haemodialysis. | [
0.08126628398895264,
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0.004746348597109318,
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0.06910336017608643,
-0.043544474989175797,
0.02598... |
10,004,968 | Furosemide was measured by gas-liquid chromatography in blood and dialysis fluid from 7 children with chronic renal failure, undergoing regular haemodialysis. It was administered chronically, in two or three daily doses (4.2-9.4mg/kg). Two children received 1 mg/kg intravenously for determination of the pharmacokinetic... | [
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0.06087440997362137,
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0.03727... |
10,004,969 | Kinetics of a high dose of piretanide in renal failure. | [
0.005629741586744785,
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0.0033219666220247746,
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... |
10,004,970 | The kinetics of piretanide was studied in patients with renal failure. After oral administration of a high dose of piretanide (96 mg), the pharmacokinetic parameters were: elimination rate constant 0.346 +/- 0.072 h-1, half life 2.00 +/- 0.35 h, and total plasma clearance 119.55 +/- 35.90 ml x min-1. Compared to the va... | [
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... |
10,004,971 | Protein binding of piretanide in normal and uraemic serum. | [
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0.05802614... |
10,004,972 | The protein binding of piretanide was assessed by continuous ultrafiltration of sera from six normal subjects and seven uraemic subjects (samples taken immediately pre-dialysis). Throughout the range of piretanide concentrations studied (0.5-4.5mM), the mean protein binding for uraemic serum was less than that for norm... | [
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0.0078101507388055325,
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... |
10,004,973 | Pharmacokinetics of bendroflumethiazide alone and in combination with propranolol and hydralazine. | [
0.029527882114052773,
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0.048495180904865265,
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0.... |
10,004,974 | Bendroflumethiazide (Bft) was administered to 6 healthy subjects at 3 different dose levels (2.5, 5 and 10mg) in a cross-over design, either as capsules (2.5mg) or as tablets (5mg). Its pharmacokinetics were evaluated then and following administration of a fixed combination of Bft and propranolol and hydralazine to a f... | [
0.000187672208994627,
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0.0133864376693964,
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0.0... |
10,004,975 | Pharmacokinetics of cimetidine and its sulphoxide metabolite during haemodialysis. | [
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0.03210420534014702,
-0.03134533390402794,
0.0111998... |
10,004,976 | A single intravenous dose of cimetidine 200mg was administered to 6 patients with severe chronic renal failure one hour prior to haemodialysis. The plasma concentrations of cimetidine and its sulphoxide metabolite at the start of haemodialysis were 2.74 +/- 0.12 and 0.76 +/- 0.08 microgram/ml, and after dialysis for 4h... | [
0.001698614563792944,
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0.02271418832242489,
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0.00837... |
10,004,977 | The pharmacokinetics of diclofenac sodium in patients with active rheumatoid disease. | [
-0.007435011677443981,
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0.021858077496290207,
0.05460895597934723,
0.... |
10,004,978 | Pharmacokinetic data for diclofenac sodium has been well established in healthy volunteers, whereas in patients with rheumatoid arthritis very little information is available in the literature. A single oral dose of enteric-coated diclofenac sodium was given to 10 patients with active rheumatoid disease, adopting the s... | [
0.0007578771910630167,
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0.04255501553416252,
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0.012087185867130756,
0.05943102762103081,
0... |
10,004,979 | Pharmacokinetics of 3H-phenylephrine in man. | [
0.0834294855594635,
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-0.0438237339258194,
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0.00975203700363636,
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0.06664... |
10,004,980 | 7-3H-phenylephrine was given to 15 volunteers by a short-infusion n = 4) or p.o. (10 volunteers, 1 patient with porto-caval anastomosis). Analysis of serum for free 3H-phenylephrine and fractionation of urinary radioactivity was performed by ion-exchange and thin-layer chromatography. As almost the same 3H-activity was... | [
0.0896788015961647,
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0.01088554598391056,
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0.09... |
10,004,981 | Difference between single and multiple dose pharmacokinetics of orphenadrine hydrochloride in man. | [
0.061036139726638794,
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0.01581118442118168,
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0.04954476282000542,
0.0312645... |
10,004,982 | Plasma concentrations of orphenadrine were measured by a specific gas chromatographic method in 5 healthy male volunteers after a single oral dose of orphenadrine hydrochloride 100mg. The single dose pharmacokinetic profile of orphenadrine was evaluated from these data. The elimination half-life ranged from 13.2-20.1h ... | [
0.04493173211812973,
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0.036998577415943146,
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0.03091755136847496,
0.05721293389797211,
... |
10,004,983 | Distribution of lithium elimination rates in a selected population of psychiatric patients. | [
0.06748278439044952,
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0.06845475733280182,
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0.06586023420095444,
0.03197859227657318,
0.03728817030787468,
0.024027811... |
10,004,984 | Chronic treatment with conventional lithium carbonate was interrupted in a selected group of 40 psychiatric patients of mixed sex and race. All patients had normal renal function. Serum samples were taken 12, 24, 36 and 48 h after the last dose and lithium was assayed by atomic absorption spectrophotometry. Decay rates... | [
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0.032470762729644775,
0.03446899354457855,
-0... |
10,004,985 | Interaction of human and chick DNA repair functions in UV-irradiated xeroderma pigmentosum-chick erythrocyte heterokaryons. | [
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0.03853156417608261,
0.03717850521206856,
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0.0... |
10,004,986 | Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine. | [
-0.018613889813423157,
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0.003713845042511821,
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0.07118312269449234,
0.0306356493383646,
0.06143... |
10,004,987 | Morphological differentiation of mitochondria in the early amphibian embryo. | [
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0.046972617506980896,
0.12285443395376205,
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0.028610680252313614,
0.00... |
10,004,988 | A temperature-sensitive mutant isolated from mouse FM3A cells defective in DNA replication at a non-permissive temperature. | [
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0.08544038236141205,
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0.03356399014592171,
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0.0... |
10,004,989 | In vivo development of adipose tissue following implantation of lipid-depleted cultured adipocyte. | [
0.005734426435083151,
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0.022759076207876205,
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-... |
10,004,990 | Cell detachment mediated by hyaluronic acid. | [
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0.057696472853422165,
0.0891672819852829,
0.05407625809311867,
-0.000003929465037799673,
0.027... |
10,004,991 | Structural and biochemical characteristics of the plasmalemma and vacuole membranes in Amoebae. | [
-0.033494558185338974,
0.020820027217268944,
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0.00958256609737873,
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-0.05897156894207001,
0.006... |
10,004,992 | Kinetic and morphological analysis of the preferential adhesion of chick embryo neuronal cells to astroglial cells in culture. | [
-0.03614120930433273,
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0.01737116277217865,
0.10974487662315369,
0.02183804102241993,
-0.08923550695180893,
-0.002552... |
10,004,993 | Similarities in protein synthesis and degradation in normal and dystrophic muscle cultures. | [
-0.03050035983324051,
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0.006450460758060217,
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0.027269773185253143,
0.01627364009618759,
0.026091035455465317,
0.0362... |
10,004,994 | Demonstration of competence and progression activities for human fibroblasts. | [
0.027500508353114128,
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0.008075036108493805,
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0.03565656766295433,
0.004461233504116535,
0.015076310373842716,
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0.1061... |
10,004,995 | The pre-pairing events in Tetrahymena. II. Partial loss of developmental information upon refeeding starved cells. | [
-0.026790611445903778,
0.03786986321210861,
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0.08913571387529373,
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-0.022... |
10,004,996 | Reversible and irreversible stages in the transition of cell surface marker during the differentiation of pluripotent teratocarcinoma cell induced with retinoic acid. | [
0.020649069920182228,
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0.04307552054524422,
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-0.03... |
10,004,997 | Nuclear transplant studies of the determination of mating type in germ nuclei of Paramecium tetraurelia. | [
0.018201105296611786,
0.0079454081133008,
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0.02603822946548462,
0.10463093221187592,
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0.048073895275592804,
0.016... |
10,004,998 | Does protein synthesis decline in lithium-treated sea urchin embryos because RNA synthesis is inhibited? | [
-0.02284703403711319,
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0.04075361788272858,
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0.01375459786504507,
0.019563978537917137,
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-0.05593015253543854,
-... |
10,004,999 | Changes in phosphorylation of nucleolar proteins correlated with inhibition of ribosomal precursor RNA processing. | [
0.024554207921028137,
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-0.06575538963079453,
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0.08640138059854507,
-0.03845714032649994,
0.07639733701944351,
0.05487576872110367,
0.08051... |
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