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10,006,802 | Combined abdominal and intrauterine pregnancy. | [
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10,006,803 | Glucagon and gastrin secretion by a pancreatic tumour and its metastases. | [
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10,006,804 | Moodiness: a heavenly problem? Observations on the pathology of moodiness. | [
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10,006,805 | 2-beta-D-Ribofuranosylthiazole-4-carboxamide, a novel potential antitumor agent for lung tumors and metastases. | [
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10,006,806 | Synthesis and hypoglycemic activity of phenylalkyloxiranecarboxylic acid derivatives. | [
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10,006,807 | A series of new 2-(phenylalkyl)oxirane-2-carboxylic acids has been synthesized and studied for its effects on the concentration of blood glucose. Most of the compounds exhibit remarkable blood glucose lowering activities in fasted rats. Structure-activity studies reveal that substituents like Cl or CF3 on the phenyl ri... | [
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10,006,808 | Darmstoff analogues. 2. Ring and side-chain effects on smooth-muscle contraction. | [
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10,006,809 | 2-cis-delta 8-Heptadecenyl-4-(hydroxymethyl)-1,3-dioxolane monosodium phosphate (1b) has been shown to be present as a major component of Darmstoff in mammalian intestine and to be a potent inducer for contraction of intestinal smooth muscle. The analogous 2-pentadecyl material 1a, also found abundantly in the intestin... | [
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10,006,810 | Preparation and antiinflammatory activity of 2- and 4-pyridones. | [
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10,006,811 | Several N-alkyl- and N-arylacetoacetamides have been self-condensed to form pyridones. N-Alkylacetoacetamides give 2-pyridones, while N-arylacetoacetamides give 4-pyridones. In an attempt to develop nonacidic, nonsteroidal antiinflammatory agents, the pyridones were tested in a carrageenan-induced pedal edema assay in ... | [
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10,006,812 | Crystal structures and pharmacological activity of calcium channel antagonists: 2,6-dimethyl-3,5-dicarbomethoxy-4-(unsubstituted, 2-methyl-, 4-methyl-, 3-nitro-, 4-nitro-, and 2,4-dinitrophenyl)-1,4-dihydropyridine. | [
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10,006,813 | The molecular structures of 2,6-dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine and the 3-methyl-, 4-methyl-, 3-nitro-, 4-nitro-, and 2,4-dinitrophenyl derivatives were determined by X-ray diffraction methods. The dihydropyridine ring in each of the compounds exists in a boat-type conformation. However, the de... | [
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10,006,814 | Mammary tumor inhibiting effect of 3,3'-diacetoxy-alpha, beta-dialkylstilbenes and of related stilbene oxides. | [
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10,006,815 | 3,3'-Diacetoxy-alpha, beta-dialkylstilbenes (alkyl = CH3 to C4H9, 1-4) 3,3'-dihydroxy-alpha, beta-diethylstilbene (5), and their corresponding stilbene oxides (6-10) were synthesized. Compounds 1-10 competitively antagonized in vitro the interaction of [3H]estradiol with its receptor. 3,3'-Diacetoxy-alpha, beta-diethyl... | [
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10,006,816 | Quantitative structure-activity relationships of aromatic esters of 1-methyl-4-piperidinol as analgesics. | [
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10,006,817 | Substituted benzoic acid esters of 1-methyl-4-piperidinol showed analgesic activity when assayed by the mouse hot-plate methods, the more potent ones falling in the morphine-codeine range. To understand how substituents on the aromatic ring affect the analgesic potency, quantitative structure-activity correlations were... | [
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10,006,818 | Comparison of quantitative structure-activity relationships of the inhibition of leukemia cells in culture with the inhibition of dihydrofolate reductase from leukemia cells and other cell types. | [
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10,006,819 | A set of 2,4-diamino-5-(3-X-phenyl)-s-triazines was used to inhibit the growth of tumor cells (L5178 leukemia) in culture. The molar concentration (C) of triazine causing 50% reduction in the rate of cell growth was used to develop a quantitative structure-activity relationship: log 1/C = 1.32 pi - 1.70 log (beta.10 pi... | [
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10,006,820 | A comparison of the inhibition of growth of methotrexate-resistant and -sensitive leukemia cells in culture by triazines. Evidence for a new mechanism of cell resistance to methotrexate. | [
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10,006,821 | Forty-five 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-X-phenyl)-s-triazine inhibitors of dihydrofolate reductase (DHFR) and methotrexate (MTX) were tested on L5178Y/R murine tumor cell culture. The concentration of inhibitor causing a 50% decrease in growth rate was determined, and from these results a quantitative stru... | [
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10,006,822 | Synthesis of pseudo cofactor analogues as potential inhibitors of the folate enzymes. | [
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10,006,823 | Reaction of 5,6,7,8-tetrahydrofolic acid (THF,7) with phosgene, thiophosgene, and cyanogen bromide gave the bridged derivatives, 5,10-(CO)-THF (8), 5,10-(CS)-THF (9), and 5,10-(C = NH)-THF (11), respectively. Catalytic hydrogenation of 10-(chloroacetyl)folic acid (2) gave 5,10-(CH2CO)-THF (12). A similar reaction with ... | [
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10,006,824 | Antiestrogen basicity--activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogues of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (tamoxifen, Nolvadex) having altered basicity. | [
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10,006,825 | A series of N-substituted (Z)-1,2-diphenyl-1-[4-(2-aminoethoxy)phenyl]-1-butenes, analogues of the antiestrogen tamoxifen (Nolvadex), in which the side-chain basicity is varied over a wide range, has been prepared to probe the importance of basicity in evoking estrogen antagonism. All of the compounds, except the pyrro... | [
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10,006,826 | Lipophilic 5'-(alkyl phosphate) esters of 1-beta-D-arabinofuranosylcytosine and its N4-acyl and 2,2'-anhydro-3'-O-acyl derivatives as potential prodrugs. | [
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10,006,827 | Lipophilic 5'-(alkyl phosphate) esters of 1-beta-D-arabinofuranosylcytosine (ara-C) and several N4-acyl and 3'-O-acyl-2,2'-anhydro derivatives of ara-C were synthesized as potential prodrugs of ara-C 5'-monophosphate (ara-CMP). Alkylphosphorylation of ara-C, N4-palmitoyl-ara-C, and N4-stearoyl-ara-C was achieved in a s... | [
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10,006,828 | Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism. | [
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10,006,829 | N-[4-[[(Benzyloxy)carbonyl]methylamino]benzoyl]-L-glutamic acid alpha-benzyl ester (2) and gamma-benzyl ester (6) served as key intermediates in syntheses of precursors to amides and peptides of methotrexate (MTX) involving both the alpha- and gamma-carboxyl groupings of the glutamate moiety. Coupling of 2 and 6 at the... | [
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10,006,830 | Adriamycin analogues. Preparation and biological evaluation of some N-perfluoroacyl analogues of daunorubicin, adriamycin, and N-(trifluoroacetyl)adriamycin 14-valerate and their 9,10-anhydro derivatives. | [
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10,006,831 | The experimental and clinical antitumor activity, as well as the low toxicity, of N-(trifluoroacetyl)adriamycin 14-valerate (AD 32), a non-DNA binding anthracycline analogue, has led us to prepare and evaluate several N-perfluoroacyl analogues of daunorubicin, adriamycin, and N-(trifluoroacetyl)adriamycin 14-valerate. ... | [
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10,006,832 | Synthesis of N-(carbonylamino)-1,2,3,6-tetrahydropyridines with analgesic, antiinflammatory, and hyperglycemic activity. | [
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10,006,833 | A group of N-(carbonylamino)-1,2,3,6-tetrahydropyridines was synthesized to investigate the effects that changes in functionality at the carbonyl group have on analgesic, antiinflammatory, and hyperglycemic activities. One of the most active analgesic compounds was N-[(ethoxycarbonyl)amino]-1,2,3,6-tetrahydropyridine (... | [
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10,006,834 | 'Pseudodiagnosticity' in an idealized medical problem-solving environment. | [
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10,006,835 | Sixty-five senior medical students chose symptom information that would allow them to assess which of two diagnoses was more appropriate for hypothetical patients. Although Bayes' theorem should have governed their data selection, 83 percent of the subjects did not choose the symptom information required for Bayesian c... | [
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10,006,836 | Physician behaviors that correlate with patient satisfaction. | [
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10,006,837 | The behavior of 15 internal medicine residents, each with 10 patients, was observed through a one-way mirror. Ratings by the patients of satisfaction with their physicians were also obtained. Patient satisfaction correlated strongly with ratings for physician courtesy and information-giving, Nonverbal behaviors such as... | [
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10,006,838 | Evaluation of behavior and development training for pediatric residents. | [
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10,006,839 | The evaluation of a behavior and development training program that was integrated into a general pediatric training residency is reported. Thirty-two residents who participated in the program were evaluated over one year on measures designed to assess residents' opinions about the relevance of behavior and development ... | [
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0.012895... |
10,006,840 | An evaluation of the simulated minority admissions exercise. | [
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10,006,841 | The Morehouse Human Values in Medicine Program, 1978-1980: reinforcing a commitment to primary care. | [
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10,006,842 | The role of the medical school in manpower planning. | [
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10,006,843 | School health for medical students. | [
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10,006,844 | Methods of grading. | [
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10,006,845 | A study of geriatric training programs in the United States. | [
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10,006,846 | Training physicians in geriatrics is essential to improving health care for the elderly. The study reported here provides a detailed analysis of geriatric education at the undergraduate, graduate, and fellowship levels. The number of programs for medical students and residents has increased but is still relatively few;... | [
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10,006,847 | Effectiveness of the AHEC concept in Colorado. | [
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10,006,848 | The SEARCH program (Colorado's area health education program) is designed to alleviate the maldistribution in health manpower by recruiting new professionals to underserved areas through student/resident rotations and to retain those professionals already there by providing accessible continuing education. Data obtaine... | [
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10,006,849 | Promotion criteria: perceptions of faculty members and departmental chairmen. | [
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10,006,850 | Medical school promotions committees tend to depend heavily on departmental evaluations of candidates for promotion. Unfortunately, departments often lack clear promotion guidelines; this results in confused perceptions of promotion criteria. Faculty members and department chairman do not always see eye to eye. When as... | [
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10,006,851 | The predictive value of the premedical grade-point average. | [
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10,006,852 | The study reported here assessed the relative utility of premedical grade-point average (GPA) in distinguishing among prospective medical students and in predicting the medical school performance of accepted applicants. Students from each of two medical classes were grouped into one of four categories depending on the ... | [
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10,006,853 | Development and validation of a test instrument for assessing value preferences in medical ethics. | [
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0.03... |
10,006,854 | A test instrument for assessing the preferences medical students display for six value categories--aesthetic, economic, political, religious, social, and theoretical--was developed using a case study approach. The major validation procedures involved the relationship of medical ethics values to general and the differen... | [
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10,006,855 | Nurses in medical school. | [
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0.035... |
10,006,856 | Each year more nurses are accepted into medical school. They bring a unique background and an already established philosophy of patient care. Thirty-three nurses currently enrolled in medical school completed questionnaires that focused on their motivation for a career change and their projected specialty preference. M... | [
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10,006,857 | A required course in decision-making for preclinical medical students. | [
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10,006,858 | Objectives, methods of instruction, and evaluation of a preclinical course in decision-making are described in this article. One set of objectives that related to learning to read and write clinical algorithms was taught by having students read a clinical algorithm about a problem, solve a patient management problem ab... | [
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0.0567287... |
10,006,859 | Medical student attendance at lectures: effect on medical school performance. | [
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10,006,860 | Divergent pediatric CME priorities in a rural area. | [
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0.074814... |
10,006,861 | Recognition of anxiety and depression by residents in a general medicine clinic. | [
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10,006,862 | Faculty promotion and tenure. | [
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0.0149... |
10,006,863 | Evaluation of medical student training in family assessment. | [
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... |
10,006,864 | Women faculty members at U.S. medical schools. | [
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10,006,865 | Association of American Medical Colleges annual meeting and annual report. | [
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10,006,866 | Delineation of sodium-stimulated amino acid transport pathways in rabbit kidney brush border vesicles. | [
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10,006,867 | We have confirmed previous demonstrations of sodium gradient-stimulated transport of L-alanine, phenylalanine, proline, and beta-alanine, and in addition demonstrated transport of N-methylamino-isobutyric acid (MeAIB) and lysine in isolated rabbit kidney brush border vesicles. In order to probe the multiplicity of tran... | [
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0.109333604... |
10,006,868 | Effects of the plant alkaloid sanguinarine on cation transport by human red blood cells and lipid bilayer membranes. | [
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10,006,869 | The plant alkaloid, sanguinarine, inhibits the ouabain-sensitive K -- Na pump and increases the downhill, ouabain-insensitive movements of K and Na in human red cells. These two effects have different temporal and concentration dependencies and are mediated by two different chemical forms of sanguinarine. The oxidized,... | [
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10,006,870 | Active potassium transport by rabbit descending colon epithelium. | [
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0.083949... |
10,006,871 | Previous studies of rabbit descending colon have disagreed concerning potassium transport across this epithelium. Some authors reported active K+ secretion under in vitro short-circuited conditions, while others suggested that K+ transport occurs by passive diffusion through a highly potassium-selective paracellular ro... | [
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10,006,872 | Primary structure of horse erythrocyte glycophorin HA. Its amino acid sequence has a unique homology with those of human and porcine erythrocyte glycophorins. | [
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0.0168982... |
10,006,873 | The complete amino acid sequence of the major sialoglycoproteins of horse erythrocyte membranes, glycophorin HA, was determined by manual sequencing methods, using tryptic, chymotryptic, and cyanogen bromide fragments. Glycophorin HA is a polypeptide chain of 120 amino acid residues and contains 10 oligosaccharide unit... | [
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0.01756411... |
10,006,874 | Correlation between lipid partition coefficients and surface permeation in Schistosoma japonicum. | [
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0.01859501749277115,
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0.07717254012823105,
0.06365008652210236,
0.02554897591471672,
0.05101676285266876,
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0.012842743657529354,
0.03111954964697361,
-0.06779588013887405,
0.05637552589178085,
0.0512157... |
10,006,875 | Comparison of transintegumental membrane permeability and partition coefficients of selected nonelectrolytes was attempted to correlate the parameters of lipid solubility, hydrophilicity, and membrane permeation in male and female schistosomes (parasites of the portal venous tributaries of man). Surface permeation (mea... | [
0.0649532824754715,
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0.035086315125226974,
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0.03090573288500309,
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0.03366483747959137,
0.09318093955516815,
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-0.009984897449612617,
-0.008969808928668499,
-0.06120556220412254,
-0.047463249415159225,
0.09624... |
10,006,876 | The external anion binding site of the human erythrocyte anion transporter: DNDS binding and competition with chloride. | [
-0.05102766305208206,
-0.11729031056165695,
-0.0059650735929608345,
0.008066922426223755,
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0.15376439690589905,
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0.004363588057458401,
0.013033248484134674,
-0.07025206834077835,
-0.02207309566438198,
0.09... |
10,006,877 | The interaction between chloride and the anion transport inhibitor DNDS (4,4'-dinitro stilbene-2,2'-disulfonate) at the external anion binding site of the human erythrocyte anion transporter was examined by two techniques: a) chloride tracer flux experiments in the presence of varying concentrations of DNDS, and b) DND... | [
-0.013395906426012516,
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0.11375901103019714,
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0.01894794963300228,
0.0875... |
10,006,878 | Effects of calcium and lanthanum on phosphate efflux from nonmyelinated nerve fibers. | [
0.04305422306060791,
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0.056805726140737534,
0.016267912462353706,
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0.05722206458449364,
0.061690978705883026,
0.037953853607177734,
0.016613120213150978,
0.04... |
10,006,879 | Phosphate efflux was measured as the fractional rate of loss of radioactivity from rabbit vagus loaded with radiophosphate. The effects of changes in extracellular calcium and of lanthanum have been investigated. In Locke solution with normal, 0.9 mM, calcium and without phosphate, the fractional rate of loss was 1.62 ... | [
0.05506930500268936,
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0.07716493308544159,
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0.032304294407367706,
0.0948527380824089,
0.08318115770... |
10,006,880 | Ionophore-mediated transmembrane movement of divalent cations in small unilamellar liposomes: an evaluation of the chlortetracycline fluorescence technique and correlations with black lipid membrane studies. | [
0.048769738525152206,
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0... |
10,006,881 | Conceptual advances in the field of membrane transport have, in the main, utilized artificial membranes, both planar and vesicular. Systems of biological interest, viz., cells and organelles, resemble vesicles in size and geometry. Methods are, therefore, required to extend the results obtained with planar membranes to... | [
0.017090795561671257,
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0.006392001640051603,
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0.047804225236177444,
0.143... |
10,006,882 | Partial purification of the Na+-dependent D-glucose transport system from renal brush border membranes. | [
-0.07493507862091064,
-0.03218022733926773,
0.022533465176820755,
-0.046599291265010834,
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0.05947931110858917,
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0.0783... |
10,006,883 | A membrane extract enriched with the Na+ -dependent D-glucose transport system was obtained by differential cholate solubilization of rat renal brush border membranes in the presence of 120 mM Na+ ions. Sodium ions were essential in stabilizing the transport system during cholate treatment. This membrane extract was fu... | [
-0.004839732311666012,
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0.022573158144950867,
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0.057846345007419586,
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0.07510311901569366,
0.016146527603268623,
... |
10,006,884 | Effects of salicylate on HCO-3/Cl- exchange across the human erythrocyte membrane. | [
0.01579207554459572,
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-0.04550762474536896,
0.0067007276229560375,
0.040098343044519424,
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0.09777013957500458,
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-0.0379599891602993,
-0.00007491361611755565,
-0.028057189658284187,
0.0610... |
10,006,885 | Changes in extracellular pH (pHo) in human red cell suspensions were monitored in a stopped-flow rapid reaction apparatus. A 20% suspension of washed human RBC in saline at pH 7 containing NaHCO3 and extracellular carbonic anhydrase was mixed with an equal volume of buffered saline solution at pH 6.7. Sodium salicylate... | [
-0.0057898396626114845,
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0.013603112660348415,
0.06344375014305115,
0.04474450647830963,
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0.06069919839501381,
0.026864735409617424,
-0.04461919516324997,
-0.011969851329922676,
0.017484232783317566,
0.0... |
10,006,886 | Potassium transport and intracellular potassium activities in rabbit gallbladder. | [
0.08170805126428604,
-0.11299873143434525,
0.04440123587846756,
0.04179975390434265,
-0.11634152382612228,
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0.07713107764720917,
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0.08558153361082077,
-0.030346635729074478,
-0.0007761361193843186,
0.019002702087163925,
0.0217263363301754,
0.03864... |
10,006,887 | Transport of benzenesulfonic acid derivatives through the rat erythrocyte membrane. | [
-0.006149685941636562,
-0.059354133903980255,
-0.044131744652986526,
0.009503625333309174,
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0.06667406111955643,
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0.031405963003635406,
-0.041386522352695465,
0.... |
10,006,888 | Transport of benzenesulfonic acid derivatives through the rat erythrocyte membrane was studied. The transport properties, such as pH-dependence and effects of reagents reacting with amino-groups, were similar to those to anions like Cl- through the human erythrocyte membrane. The rate of transport of anions through rat... | [
-0.0006730848690494895,
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0.007082852069288492,
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-0.02823575958609581,
0.0... |
10,006,889 | Transepithelial Na+ transport and the intracellular fluids: a computer study. | [
0.027957946062088013,
-0.11666497588157654,
0.02814505249261856,
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0.06141058728098869,
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0.0682055652141571,
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0.05863002687692642,
0.128... |
10,006,890 | Computer simulations of tight epithelia under three experimental conditions have been carried out, using the rheogenic nonlinear model of Lew, Ferreira and Moura (Proc. Roy. Soc. London. B 206:53-83, 1979) based largely on the formulation of Koefoed-Johnsen and Ussing (Acta Physiol. Scand. 42: 298-308. 1958). First, an... | [
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0.09763507544994354,
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-0.0126543203368783,
0.06528319418430328,
0.11679... |
10,006,891 | K+ transport in "tight' epithelial monolayers of MDCK cells. | [
-0.010108520276844501,
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-0.05065998435020447,
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0.10315944254398346,
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-0.01294342614710331,
0.01052922010421753,
0.026... |
10,006,892 | Bidirectional transepithelial K+ flux measurements across 'high-resistance' epithelial monolayers of MDCK cells grown upon millipore filters show no significant net K+ flux. Measurements of influx and efflux across the basal-lateral and apical cell membranes demonstrate that the apical membranes are effectively imperme... | [
0.06725294888019562,
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0.07608330249786377,
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0.016026310622692108,
0... |
10,006,893 | Morphology and distribution of chromaffin cells in the adrenal gland of Cordylidae (Reptilia, Sauria): a comparative study. | [
-0.04305112734436989,
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0.0... |
10,006,894 | The distribution of the adrenaline and noradrenaline chromaffin cells in the adrenal glands of 10 members of the family Cordylidae have been examined. In the genus Gerrhosaurus, all the catecholamine cells lie on the surface of the adrenal gland, forming a continuous envelope of one or two layers of cells that mainly c... | [
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0.046414297074079514,
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-0.0646672248840332,
0.04... |
10,006,895 | Immunoglobulin changes after varied resuscitation regimens. | [
0.03275090828537941,
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0.000287432165350765,
0.014373788610100746,
0.04585373029112816,
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0.02335350401699543,
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0.07190311700105667,
0.053423669189214706,
0.1064542... |
10,006,896 | Prior studies showed that albumin supplementation of the resuscitation for hypovolemic shock caused an increase in serum albumin but a fall in serum globulins; immunoglobulins were not measured. Using frozen sera, immunoglobulins (IgG, IgM, IgA, IgD) were measured in 184 severely injured patients including 40 patients ... | [
0.05636947974562645,
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0.0435740202665329,
0.0026153763756155968,
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0.017755473032593727,
0.0019555888138711452,
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-0... |
10,006,897 | CT in head trauma. | [
-0.01601482927799225,
0.03980980068445206,
0.05176147446036339,
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0.049158696085214615,
0.07566875964403152,
0.01565462537109852,
0.018694311380386353,
0.045... |
10,006,898 | Delayed deterioration in the syndrome of temporal lobe contusion: evaluation by computed tomography (CT). | [
0.0368376150727272,
0.0032177853863686323,
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0.04159041494131088,
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0.0037955117877572775,
0.0009021503501571715,
0.021244054660201073,
-0.0021867675241082907,
0.0... |
10,006,899 | The clinical and computed tomographic (CT) features of three consecutive cases of temporal lobe contusion emphasize the presentation and frequent subsequent progressive neurological deterioration. The initial presentation was one of lethargy and combativeness with little or no focal neurological deficits. Thereafter al... | [
0.05434612184762955,
0.029217753559350967,
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0.0030414792709052563,
0.012497310526669025,
-0.01790756732225418,
0.008044073358178139,
... |
10,006,900 | Ocular injuries in automobile crashes. | [
0.06219476833939552,
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0.0783526673913002,
0.002798178233206272,
0.0816173106431961,
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0.0787806361913681,
0.04293466731905937,
0.023020513355731964,
-0.030296429991722107,
0.0500187762... |
10,006,901 | Tempered windshields commonly used in Europe have been shown to be related to the relatively high incidence of ocular injuries. Although windshields of the High Penetration Resistant (HPR) type in cars in North America are not at all significantly involved in ocular injuries, still about 50 % of the injuries of the eye... | [
0.0293746180832386,
0.029528887942433357,
0.06161333620548248,
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0.057099249213933945,
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0.061803240329027176,
0.09219762682914734,
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0.012346487492322922,
0.09638357162475586,
0.021265994757413864,
0.062429558485746384,
0.043345... |
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