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10,009,703 | Visuo-motor behavior and visual acuity were assessed in animals who experienced monocular vision after a prolonged period of binocular deprivation. In animals who experienced initial binocular suture, there was limited recovery and no difference between the initially opened and late opened eye. In animals who experienc... | [
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10,009,704 | Post-training amygdaloid lesions impair retention of an inhibitory avoidance response. | [
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10,009,705 | The study examined the effect of pre- and post-training bilateral amygdaloid lesions on retention of a one-trial inhibitory avoidance response. Groups of rats, including unimplanted controls and implanted controls, were trained and tested for retention at 4, 7 or 12 days following training. The lesions were made at one... | [
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10,009,706 | Retention performance of a learned delayed-alternation task after chemical lesions of the cats mediodorsal nucleus. | [
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10,009,707 | The mediodorsal nucleus of the thalamus was lesioned in cats, which had learned a spatial delayed-alternation task. Lesions were carried out with kainic acid or ibotenic acid. From altogether 29 cats, 9 cats with bilateral and 6 cats with unilateral lesions of the mediodorsal nucleus together with a control group of 4 ... | [
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10,009,708 | The accuracy of tilt discrimination in the rabbit. | [
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10,009,709 | [Metabolisms of cyanide in amyotrophic lateral sclerosis (author's transl)]. | [
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10,009,710 | [Electron microscopic, abnormalities of the liver in amyotrophic lateral sclerosis]. | [
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10,009,711 | [Effects of electric stimulation of the unilateral locus coeruleus on cerebral circulation in cats (author's transl)]. | [
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10,009,712 | [A proposal of clinical grading for hypertensive cerebellar hemorrhage (author's transl)]. | [
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10,009,713 | [Neuropathological study of amyotrophic lateral sclerosis and parkinsonism-dementia in Guam: an analysis of 24 autopsy cases (author's transl)]. | [
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10,009,714 | [Amyotrophic lateral sclerosis and metallic metabolisms (author's transl)]. | [
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10,009,715 | [Suspected cases of familial Alzheimer's disease-a case report and a study on aneuploidy in leukocytes (author's transl)]. | [
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10,009,716 | Sibling cases of probable familial Alzheimer's disease were presented. Although familial occurence of Alzheimer's disease has been reported and relatively well known in the western literature, little attention has been paid to the matter in Japan. Some of the clinical features of our cases, for example, an earlier onse... | [
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10,009,717 | [The effects of phenobarbitone on the inhibitory action of GABA (author's transl)]. | [
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10,009,718 | [A case of Sturge-Weber syndrome with the abnormal angiographic findings in the cerebral venous system (author's transl)]. | [
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10,009,719 | A case of Sturge-Weber syndrome with marked abnormalities in the cerebral venous system was reported. The patient was a 2-year old boy who was admitted to the Department of Neurosurgery with the chief complaints of left hemiparesis and left focal seizures. He had vascular nevi on the forehead and upper lip of his face,... | [
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10,009,720 | Assessment of atrioventricular septal defects by two dimensional echocardiography. | [
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10,009,721 | Ninety-six patients with an atrioventricular septal defect were assessed by two dimensional echocardiography. Forty-eight patients were judged as having two discrete valve orifices. In this group, 37 had an intact ventricular septum and 11 a ventricular septal defect. Two patterns of attachment of the valve leaflets to... | [
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10,009,722 | Cardiac work and myocardial substrate extraction in congestive cardiomyopathy. | [
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10,009,723 | New prognostic criteria for children with cyanotic congenital heart disease. | [
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10,009,724 | Available oxygen and oxygen unloading capacity were determined at the time of cardiac catheterisation, from blood gas analysis, p 50 in vivo, and haemoglobin, in 79 children with cyanotic congenital heart disease, their age ranging from 2 weeks to 14 years. The patients were followed up for six months to find out how m... | [
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10,009,725 | "Duplication" of aortic cusp. New M-mode echocardiographic sign of intimal tear in aortic dissection. | [
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10,009,726 | M-mode and two-dimensional echocardiograms were obtained in a patient with acute dissecting aneurysm of the ascending aorta. The M-mode echocardiogram disclosed apparent "duplication" of the non-coronary aortic cusp. Two-dimensional echocardiograms showed this finding to be the result of the motion of a flap of torn ao... | [
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10,009,727 | Survival after subacute cardiac rupture. | [
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10,009,728 | A 43-year-old man collapsed suddenly, with pericardial tamponade, seven weeks after an inferior myocardial infarction. Pericardiocentesis disclosed very heavily blood stained fluid. Left ventricular angiography 10 days later showed a left ventricular aneurysm. At operation a left ventricular false aneurysm was resected... | [
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10,009,729 | Persistent right sinus venosus valve. | [
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10,009,730 | A 13-year-old girl presented with clinical features of pulmonary stenosis and regurgitation. Haemodynamic studies suggested the presence of a right ventricular tumour. M-mode and two dimensional echocardiograms indicated one or probably two soft thin walled structures originating from the right atrium. At operation a p... | [
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10,009,731 | Lignocaine therapy in myocardial infarction. | [
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10,009,732 | Ambulatory electrocardiographic recording in endurance athletes. | [
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10,009,733 | Data from ambulatory electrocardiographic recording in 35 highly trained endurance athletes and in 35 non-athletic controls of similar ages are given. The minimal, mean hourly, and maximal heart rates were significantly lower in the athletes. Thirteen athletes (37 . 1%) but only two controls (5 . 7%) had sinus pauses e... | [
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10,009,734 | Cardiac sequelae of acute head injury. | [
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10,009,735 | An intensive 72 hour study of the cardiovascular effects of severe diffuse brain injury was made in seven patients. No other major injury was present. Patients received optimal care very rapidly after injury and intracranial pressure, which was continuously monitored, was maintained at or just above normal by elective ... | [
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10,009,736 | Abnormal Q waves in right sided chest leads provoked by onset of right bundle-branch block in patients with anteroseptal infarction. | [
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10,009,737 | In five cases of anteroseptal myocardial infarction complicated by intermittent right bundle-branch block, the onset of right bundle-branch block provoked the appearance of abnormal Q waves in leads V1 and V2, whereas a small initial R wave was present in the same leads during normal conduction. The intermittency of th... | [
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10,009,738 | Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction. | [
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10,009,739 | Serum C-reactive protein (CRP) and creatine kinase (CK) MB levels were measured prospectively in patients with definite myocardial infarction, patients with spontaneous or exercise-induced angina, subjects undergoing coronary arteriography, and patients with non-cardiac chest pain. All individuals with infarction devel... | [
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10,009,740 | Two cases with spontaneous spasm of left main trunk. | [
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0.0118698189... |
10,009,741 | Relation of P-S4 interval to left ventricular end-diastolic pressure. | [
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10,009,742 | Reports have suggested that the interval between P wave onset and the fourth heart sound (P-S4 interval) reflects changes in left ventricular myocardial stiffness. We made simultaneous measurements of the P-S4 or atrial electrogram to S4 (A-S4) interval and left ventricular pressure in 19 patients with coronary artery ... | [
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10,009,743 | Hang-out time of pulmonary valve in d-transposition of great arteries. | [
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... |
10,009,744 | Recently it has been shown that in patients with transposition of the great arteries the isometric relaxation time of the left ventricle could be negative in the presence of normal pulmonary artery pressure. In order to find an explanation for this apparently paradoxical situation, it was decided to evaluate the import... | [
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0.040... |
10,009,745 | Angio-pathological appearances of pulmonary valve in pulmonary atresia with intact ventricular septum. Interpretation of nature of right ventricle from pulmonary angiography. | [
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10,009,746 | Correlative angiographic-anatomical studies in 19 cases of pulmonary atresia with infarct ventricular septum showed the following relations between the angiographic appearance of the pulmonary valve and the morphology of the right ventricle. (1) Doming of the pulmonary valve was associated with a nearly normal-sized ri... | [
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10,009,747 | Study of children of parents operated on for congenital cardiovascular malformations. | [
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0.005281322170048952,
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0.012... |
10,009,748 | The incidence of congenital cardiovascular malformation was studied in 246 children of 166 index patients who had been operated upon for this. Twelve children were affected (4 . 9%). More than half of these had the same malformation as the parent. The incidence of other extracardiac congenital abnormalities did not exc... | [
0.018583815544843674,
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10,009,749 | Isolated atresia of the aortic arch in a 65-year-old man. Surgical treatment and review of published reports. | [
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10,009,750 | Echocardiographic diagnosis of isolated pulmonary valve endocarditis. | [
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0.07... |
10,009,751 | Rapid disappearance of left ventricular mass (presumed thrombus) in a patient with cardiomyopathy. | [
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0.03989... |
10,009,752 | A man aged 41 years with a clinical diagnosis of cardiomyopathy and hepatic insufficiency was found, on angiocardiography, to have a mass, presumably a thrombus, within the left ventricle. A second angiocardiogram performed five days later showed that the thrombus had disappeared. The mechanism invoked was more probabl... | [
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10,009,753 | Neuromuscular blockade. | [
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0.0302257... |
10,009,754 | Dosage adjustment in renal insufficiency. | [
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10,009,755 | Bias. | [
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10,009,756 | The pharmacokinetics of cimetidine and its sulphoxide metabolite in patients with normal and impaired renal function. | [
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0.0553... |
10,009,757 | 1 The pharmacokinetics of cimetidine and its sulphoxide metabolite was studied after a single intravenous dose of 200 mg cimetidine in nine patients with normal renal function and ten patients with severe renal failure on regular haemodialysis and during continuous oral cimetidine treatment in ten patients with normal ... | [
0.026039032265543938,
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0.038... |
10,009,758 | A study of pethidine kinetics and analgesia in women in labour following intravenous, intramuscular and epidural administration. | [
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... |
10,009,759 | 1 Epidural administration of opiates for analgesia has recently generated widespread interest and would theoretically be advantageous as a method for relief of pain in labour. 2 Plasma pethidine concentrations were measured after intravenous, intramuscular and epidural administration of pethidine to women in labour and... | [
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0.02700... |
10,009,760 | Pharmacokinetics of single doses of sulphinpyrazone and its major metabolites in plasma and urine. | [
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10,009,761 | 1 High pressure liquid chromatographic assays for the estimation of sulphinpyrazone and its sulphide, sulphone and p-hydroxy metabolites in plasma and urine are described. 2 Five normal volunteers received 200 mg and 400 mg sulphinpyrazone orally. Sulphinpyrazone was rapidly absorbed and eliminated with a half-life of ... | [
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10,009,762 | Comparison of prorenoate potassium and spironolactone after repeated doses and steady state plasma levels of active metabolites. | [
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10,009,763 | 1 After repeated single daily doses, the aldosterone antagonists prorenoate potassium and spironolactone were compared with regard to renal antimineralocorticoid activity, plasma potassium concentration and steady state plasma levels of their active metabolites, prorenone and canrenone respectively, in a balanced cross... | [
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... |
10,009,764 | Ethanol-induced increase in procainamide acetylation in man. | [
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10,009,765 | 1 The effect of ethanol on procainamide pharmacokinetics was studied in humans by two different experimental designs. In one, ethanol was given 1.5 h after taking the drug followed by hourly drinks, while in the other ethanol was given 2 h before and subsequently after taking the drug. 2 In both studies, ethanol caused... | [
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0.04... |
10,009,766 | Antihypertensive action of acebutolol (Sectral) when used concomitantly with hydrochlorothiazide. | [
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10,009,767 | 1 In a placebo-controlled study, the respective anti-hypertensive effects of hydrochlorothiazide and hydrochlorothiazide plus the beta-adrenoceptor blocker acebutolol were assessed in 18 patients with moderately severe essential hypertension. 2 Hydrochlorothiazide 100 mg daily decreased the mean supine blood pressures ... | [
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10,009,768 | Comparison of two recently published algorithms for assessing the probability of adverse drug reactions. | [
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10,009,769 | 1 A simple valid and reliable method for estimating the probability of adverse drug reactions (adverse drug reactions probability scale, APS) has been recently described (Naranjo et al., 1981a). 2 The results using APS were compared to those obtained with another more detailed algorithm (adverse reactions scoring syste... | [
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0... |
10,009,770 | Antipyrine elimination in saliva after low-dose combined or progestogen-only oral contraceptive steroids. | [
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10,009,771 | 1 A 'low-dose' combined oral contraceptive steroid (OCS) preparation containing 30 microgram ethinylo-estradiol and 150 microgram levonorgestrel was found to reduce significantly antipyrine clearance in a group of women acting as their own controls. 2 An OCS preparation containing only a progestogen (75 microgram norge... | [
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10,009,772 | Bile and serum levels of tinidazole after a single oral dose. | [
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0.1236... |
10,009,773 | Atenolol disposition in young and elderly subjects. | [
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10,009,774 | The effect of age on the responses of human isolated arteries to noradrenaline. | [
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0.10163... |
10,009,775 | Bioavailability of sublingual ergotamine. | [
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10,009,776 | Verapamil bioavailability and dosage in liver disease. | [
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0.... |
10,009,777 | Dose-dependent pharmacokinetics with single daily dose slow release theophylline in patients with chronic lung disease. | [
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0.0914195328950882,
0.011265357956290245,
0.1259429007... |
10,009,778 | Saliva theophylline concentrations after a single oral dose. | [
0.033155374228954315,
-0.03764476999640465,
0.03479279205203056,
-0.05070403590798378,
0.0013771624071523547,
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0.043233148753643036,
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0.03904801979660988,
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0.0012812053319066763,
-0.013699990697205067,
-0.0550360269844532,
0.1... |
10,009,779 | Plasma protein binding and half-life of sulphisoxazole (sulphafurazole). | [
-0.028564123436808586,
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0.024461420252919197,
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0.007744038477540016,
0.0212716031819582,
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0.03311672806739807,
-0.04542268440127373,
0.015596813522279263,
0.061271101236343384,
-0.0012603334616869688,
0.08... |
10,009,780 | Six months experience of new procedures affecting the conduct of clinical trials in the United Kingdom. | [
0.045659005641937256,
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0.01326688937842846,
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0.03488823398947716,
0.0032208887860178947,
0.06902916729450226,
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-0.00... |
10,009,781 | Are propranolol and nifedipine synergistic in angina pectoris? | [
0.05549120903015137,
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0.051551446318626404,
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0.0732... |
10,009,782 | Creatinine clearance, different methods of determination. | [
0.0009430274367332458,
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0.005962759722024202,... |
10,009,783 | Placebos and other comparative treatments. | [
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0.06179561838507652,
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0.0333... |
10,009,784 | Influence of sex, menstrual cycle and oral contraception on the disposition of nitrazepam. | [
-0.006806459277868271,
0.0426119863986969,
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0.05102543160319328,
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0.048074617981910706,
0.032655153423547745,
0.02172... |
10,009,785 | 1 The effects of sex and oral contraceptives (OC) on the disposition of oral nitrazepam were studied in six healthy young males, in six healthy young females in the follicular and luteal phase of the menstrual cycle and in six healthy young females using OC-steroids in two stages of the pill cycle. 2 There was no influ... | [
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0.06446141749620438,
0.0036677513271570206,
-... |
10,009,786 | The gut wall metabolism of ethinyloestradiol and its contribution to the pre-systemic metabolism of ethinyloestradiol in humans. | [
0.04063911363482475,
-0.010012649931013584,
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0.0058578429743647575,
0.018160516396164894,
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0.04073946923017502,
-0.03... |
10,009,787 | 1 Five patients have been studied to determine the contribution of the gut wall to the pre-systemic metabolism of ethinyloestradiol. All patients had a catheter inserted into their hepatic portal vein as part of their surgical management. 2 After an oral dose of 50 micrograms (65 microCi) ethinyloestradiol, blood sampl... | [
0.07628503441810608,
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0.002679623896256089,
0.049927424639463425,
0.02... |
10,009,788 | Tachyphylaxis after repeated dosage of decamethonium in anaesthetized man. | [
0.1096220389008522,
0.02233029156923294,
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0.03348655253648758,
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0.008172957226634026,
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0.013492848724126816,
0.039269719272851944,
0.085666... |
10,009,789 | 1 The tetanic and single twitch responses to the adductor pollicis muscle were used to study the neuromuscular effects of repeated dosage of decamethonium in nine anaesthetized patients. 2 In two of three patients who received the same total dose of decamethonium in three separate series of injections, blockade of the ... | [
0.061689592897892,
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0.005330154672265053,
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0.012928290292620659,
0.0003121056070085615,
-0.03936572000384331,
0.07545769214630127,
0.084157... |
10,009,790 | Isoniazid disposition, comparison of isoniazid phenotyping methods in and acetylator distribution of Japanese patients with idiopathic systemic lupus erythematosus and control subjects. | [
0.007504645735025406,
-0.04689367488026619,
-0.012313064187765121,
0.09061291068792343,
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0.12680476903915405,
0.014804825186729431,
-0.02733532525599003,
0.... |
10,009,791 | 1 Plasma levels of isoniazid (INH) and acetyl INH in plasma were measured with a spectrofluorometric method, and INH and its metabolites (acetyl INH, mono-acetylhydrazine, diacetylhydrazine and free hydrazine) excreted in urine were measured with a gas chromatography-mass spectrometry, respectively, after an oral dose ... | [
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0.0008637744467705488,
0.05399307236075401,
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0.0... |
10,009,792 | A simple pharmacokinetic method for separating the three acetylation phenotypes: a preliminary report. | [
0.005004305858165026,
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-0.11271774023771286,
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0.053353480994701385,
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-0.055930521339178085... |
10,009,793 | 1 Until recently, phenotyping the N-acetyltransferase enzyme had been restricted to distinguishing the slow acetylators from the rapid. Further separation of the heterozygous rapid phenotype from the homozygous rapid phenotype has only been possible by detailed pharmacokinetic studies using sulphadimidine and necessita... | [
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0.02625325880944729,
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0.035441648215055466,
0.019177688285708427,
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10,009,794 | Differential effects of enzyme induction on antipyrine metabolite formation. | [
-0.004715716000646353,
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0.01733250357210636,
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0.03998536616563797,
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0.020609069615602493,
-0.019485831260681152,
0.0... |
10,009,795 | 1 The influence of enzyme induction with antipyrine and pentobarbitone was studied on the rates of formation of the major metabolites of antipyrine: 4-hydroxyantipyrine, norantipyrine and 3-hydroxymethyl-antipyrine + 3-carboxy-antipyrine. The inducing drugs were given to panels of healthy volunteers for 8 days and prio... | [
0.03906799852848053,
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0.010510037653148174,
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-0.10401801764965057,
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0.0655956044793129,
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0.030132027342915535,
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0.0... |
10,009,796 | Effect of rifampicin on metoprolol and antipyrine kinetics. | [
0.004596640355885029,
-0.08133158087730408,
-0.04969911277294159,
0.030077308416366577,
0.028692835941910744,
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0.15558822453022003,
0.08403480798006058,
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0.009098484180867672,
0.03623885661363602,
-0.00... |
10,009,797 | 1 Effects of rifampicin on the pharmacokinetics of single oral doses of metoprolol and antipyrine are reported. 2 Rifampicin, administered daily for 15 days, reduced the area under the plasma concentration-time curve (AUC) of metoprolol but the rate constant for elimination (beta) of metoprolol from plasma did not alte... | [
0.004766860976815224,
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0.0664282888174057,
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0.03616725280880928,
0.017765292897820473,
0.01141... |
10,009,798 | Comparison of the pharmacodynamic and pharmacokinetic profiles of single and multiple doses of a commercial slow-release metoprolol formulation with a new Oros delivery system. | [
0.015368986874818802,
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0.008604115806519985,
0.019034545868635178,
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0.030560148879885674,
-0.... |
10,009,799 | 1 A new osmotic pressure mediated delivery system for metoprolol (Lopresor Oros) has been evaluated by measuring the haemodynamic effects and pharmacokinetics after single and multiple oral dosing in young healthy volunteers. 2 Similar studies have been carried out in the same group using equivalent single and multiple... | [
-0.011622033081948757,
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0.0074051073752343655,
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0.0161188542842865,
-0.0... |
10,009,800 | The use of buccal partitioning as a model to examine the effects of aluminium hydroxide gel on the absorption of propranolol. | [
0.026323512196540833,
-0.05927705392241478,
0.0063840835355222225,
0.081730917096138,
0.0021274040918797255,
0.034373532980680466,
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0.03634117171168327,
0.021943196654319763,
-0.... |
10,009,801 | 1 A buccal partitioning model showed no absorption interaction between propranolol and aluminium hydroxide gel in three volunteer subjects. 2 The previously reported in vivo interaction is therefore not due to propranolol adsorption to, or complexation with the antacid but is more probably due to a decreased gastric em... | [
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0.04329155758023262,
0.0008563199662603438,
0.... |
10,009,802 | Antihypertensive effects of lofexidine in patients with essential hypertension. | [
-0.015905924141407013,
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0.00006688870780635625,
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-0.042473480105400085,
-0.03877316787838936,
0.018217168748378754,
0... |
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