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10,009,803 | 1 Single oral doses of lofexidine, 0.1, 0.3, and 0.6 mg produced dose related decreases in supine and standing arterial pressure and heart rate in nineteen patients with essential hypertension. 2 A mean oral antihypertensive threshold dose of less than 0.1 mg was estimated. 3 Lofexidine decreased mean urinary noradrena... | [
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10,009,804 | On the role of alpha 1-acid glycoprotein in lignocaine accumulation following myocardial infarction. | [
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10,009,805 | 1 Blood plasma and free lignocaine concentrations have been measured 12 h after beginning a constant infusion of 2 mg/min and again at the end of the infusion (36-72 h) in five patients with myocardial infarction (MI) and compared with five control patients who did not develop objective evidence of MI. 2 In MI patients... | [
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10,009,806 | Disopyramide pharmacokinetics during recovery from myocardial infarction. | [
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10,009,807 | 1 Previous pharmacokinetics studies of disopyramide in patients with ischaemic heart disease include unexplained reports of poor bioavailability and extremely long elimination half-lives which undermine accepted dosage recommendations. 2 Disopyramide pharmacokinetics were investigated after intravenous and oral adminis... | [
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10,009,808 | Plasma protein binding of phenytoin in the aged: in vivo studies. | [
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10,009,809 | 1 The relation between plasma water phenytoin content and whole plasma phenytoin content in vivo was studied in 22 elderly patients (age range 62 to 87 years) and in 22 young patients (age range 18 to 33 years), all of whom were taking the drug for epilepsy. 2 The percentage of the drug existing unbound in plasma was s... | [
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10,009,810 | Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients. | [
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10,009,811 | 1 The absorption of single doses of diazepam in six adult epileptic subjects following intravenous, oral and rectal administration were studied in order to evaluate the usefulness of the latter in emergency situations in the adult. 2 Diazepam tablets (Valium, Roche) and rectal solution (Valium solution for intravenous ... | [
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10,009,812 | Bronchodilator activity of prazosin in patients with allergic rhinitis and asthma. | [
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10,009,813 | Protein binding of chloroquine in the presence of aspirin. | [
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10,009,814 | A comparison of the bioavailability of two brands of phenytoin. | [
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10,009,815 | Effect of oral 16,16-dimethyl-prostaglandin E2 on basal acid output in man. | [
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10,009,816 | Relation of growth delay to cure for experimental tumour systems conforming to Poisson cure statistics. | [
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10,009,817 | In tumour regrowth-delay experiments, the analysis of results in the higher dose ranges may be complicated by a dose-dependent proportion of non-recurrent (cured) tumours, whose inclusion in the analysis is not straightforward. A study of the relation of growth delay to cure has been carried out using a model of tumour... | [
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10,009,818 | Cellular repair factors influencing radiocurability of human malignant tumours. | [
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10,009,819 | We have studied the repair of X-ray-induced, potentially lethal damage (PLD) in 9 human tumour lines derived from tumours of varying radiocurability. Cells derived from 3 tumours considered non-radiocurable (1 osteosarcoma, 2 melanoma) repaired significantly more X-ray PLD than cells from 3 tumours considered radiocura... | [
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10,009,820 | Mutagenic and tumourigenic properties of the spores of Aspergillus clavatus. | [
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10,009,821 | Spore walls of a sputum-derived isolate of Aspergillus clavatus yielded mutagen(s) when their extracts were fractionally precipitated with ethanol following alkaline hydrolysis. After spores were given by nasal inoculation to 6-8-week-old CF-1 mice, light and electron microscopy of lung sections showed that they had be... | [
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10,009,822 | Stage-specific breast-cancer incidence rates by age among Japanese and Caucasian women in Hawaii, 1960-1979. | [
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10,009,823 | We have analysed the age- and stage-specific breast-cancer incidence rates of Japanese and Caucasian women in Hawaii for a 20-year period. A comparison of the 1192 Japanese and 1531 Caucasian patients by stage at diagnosis showed that Japanese women were likely to have breast cancer diagnosed at an earlier stage than C... | [
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10,009,824 | Mesothelioma mortality in asbestos workers: implications for models of carcinogenesis and risk assessment. | [
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10,009,825 | Mesothelioma death rates in asbestos workers appear to be proportional to the 3rd or 4th power of time from first exposure under a wide range of conditions of exposure for both pleural and peritoneal tumours, though the peritoneal:pleural ratio depends on fibre dimension and type. Age at first exposure has little or no... | [
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10,009,826 | Endothelial cell proliferation as a novel approach to targeting tumour therapy. | [
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10,009,827 | Sensitivity to RNase treatment of ribosomes and rRNA from normal rat liver and Novikoff hepatoma. | [
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10,009,828 | Tumour-promoting diterpene esters prevent macrophage activation. | [
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10,009,829 | The age-mortality curve of endemic pleural mesothelioma in Karain, Central Turkey. | [
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10,009,830 | Critique of a study of cancer incidence and alcohol/cigarette consumption in Hawaii. | [
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10,009,831 | Response of two mouse tumours to hyperthermia with CCNU or melphalan. | [
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10,009,832 | The in vivo response of B16 melanoma and Lewis lung carcinoma to combinations of hyperthermia and graded doses of CCNU or Melphalan was studied. To obtain dose-response curves and quantitative comparisons of different treatments, an agar-colony assay was used to measure survival of cells from excised tumours. For heati... | [
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10,009,833 | Response of a high-glucuronidase human tumour xenograft to aniline mustard. | [
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10,009,834 | The HT29R colonic adenocarcinoma xenograft has been shown to be rich in the enzyme beta-glucuronidase. Experiments in rodent systems have demonstrated a marked anti-tumour effect of the drug aniline mustard (AM) on tumours with high levels of this enzyme (e.g. the plasmacytomas PC5 and PC6). We have found that AM is no... | [
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10,009,835 | Cimetidine enhancement of cyclophosphamide antitumour activity. | [
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10,009,836 | Male DBA2 mice were given 10(6) P-388 leukaemic cells i.p. and cimetidine (CMT) at 100 mg/kg 1 day for 10 days, or as a single 100 mg/kg injection 30 min before cyclophosphamide (CTX). CMT significantly prolonged the survival of groups of mice receiving 50, 100 and 200 mg/kg of CTX 3 days after tumour inoculation. Medi... | [
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10,009,837 | Metastatic inefficiency in mice bearing B16 melanomas. | [
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10,009,838 | When injected i.v. into mice, the F10 subline of B16 melanoma cells produced significantly more lung tumours over a 3-week period than cells of the F101.r-6 subline. However, in animals bearing intramuscular tumours produced by these sublines, the high pulmonary-colonization potential of the F10 cells was not realized,... | [
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10,009,839 | Decrease in tumour growth by injections of histamine or serotonin in fibrosarcoma-bearing mice: influence of H1 and H2 histamine receptors. | [
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10,009,840 | C3H and C57 BL/6 mice carrying methylcholanthrene-induced fibrosarcomas were injected i.p. daily with histamine, metiamide (anti-histamine type-2 receptor), histamine + metiamide, mepyramine (anti-histamine type-1 receptor), serotonin and methysergide (anti-serotonin). Inhibition of tumour growth and lengthened surviva... | [
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0.0188674... |
10,009,841 | A new melanoma seeker for possible clinical use: selective accumulation of radiolabelled thiouracil. | [
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10,009,842 | In a previous report we have shown that a few substances, especially thiouracil, are incorporated as false precursors into melanin during its synthesis. In the present investigation, we have intensified our studies on the incorporation of thiouracil into melanotic melanomas. Firstly, the distribution and retention of b... | [
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10,009,843 | Postchemotherapy staging laparotomy in Hodgkin's disease. | [
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10,009,844 | Seventeen patients with Hodgkin's disease who had a staging laparotomy (SL) within 2 months of the completion of initial chemotherapy are presented. Only 1 patient had a positive laparotomy. Postchemotherapy SL allows any residual active disease to be assessed, but the incidence of positive finding may be small, and su... | [
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10,009,845 | Bias and the association of mammographic parenchymal patterns with breast cancer. | [
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... |
10,009,846 | We have carried out a case-control study to evaluate the association between Wolfe's mammographic patterns and the risk of breast cancer, and to examine the influence of control selection and the radiologist who read the films upon the results obtained. Mammograms of the non-cancerous breast of 183 women with unilatera... | [
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10,009,847 | Mammographic signs as risk factors for breast cancer. | [
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10,009,848 | We have carried out a case-control study to examine the relationship between mammographic signs and breast cancer. The mammographic signs assessed were prominent ducts and dysplasia. The cases were a group of 183 women with histologically verified unilateral breast cancer. The controls were a group of women attending a... | [
0.1001858115196228,
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10,009,849 | Cells bearing Fc receptors in human malignant solid tumours. | [
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0.0287... |
10,009,850 | Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells id... | [
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10,009,851 | Blood basophils in lung cancer. | [
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0.01... |
10,009,852 | Peripheral-blood basophils were counted, in thick smears, in samples from patients with primary bronchial carcinoma, from patients in the same wards and from normal individuals. The median counts for patients with other chest conditions (15.5/microliter) and bronchial-carcinoma patients free of tumour months to years a... | [
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0.030... |
10,009,853 | The Tennessee antigen test. An evaluation in cancer and non-cancer patients and normal subjects. | [
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0... |
10,009,854 | The Tennagen test has been evaluated in "normal" subjects, patients with cancer (predominantly colorectal) and patients with non-malignant disease. The incidence of positive values was found to be higher in patients with clinically active cancer than in those with benign conditions or normal subjects. In our hands the ... | [
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0... |
10,009,855 | Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo. | [
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0.07053979486227036,
0.0486693... |
10,009,856 | The survival of epidermal cells in vivo has been used to assess potential radiosensitizers. Mouse skin was made acutely hypoxic for the irradiations, to give radioprotection by a factor of 2.7-3.0. Several concentrations of each drug were used to determine whether any of them were more effective sensitizers than misoni... | [
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0.07251378893852234,
0.1321309953927... |
10,009,857 | Oxygen tensions in multicell spheroids of two cell lines. | [
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10,009,858 | O2 tensions (Po2) were measured with microelectrodes in multicellular spheroids from EMT6/Ro and V-79-171-B cells. The measurements were performed in spheroids kept in flowing growth medium that was equilibrated with 5% CO2 and air at a temperature of 37 degrees C and contained 5.5 mM glucose. The recorded Po2 profiles... | [
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10,009,859 | Differential effect of hyperthermia and x-irradiation on regrowth rate and tumour-bed effect for a rat sarcoma. | [
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0.047419954... |
10,009,860 | The regrowth rate of the rat sarcoma SSB1a was assessed, following treatment with either X-rays or hyperthermia. The growth rate of untreated tumours implanted in pre-irradiated or pre-heated normal tissue was also measured. For treatments giving similar levels of tumour regrowth delay, the regrowth of irradiated tumou... | [
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0.0781... |
10,009,861 | The penetration of misonidazole into a mature structural cartilage. | [
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0.04451873525977135,
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0.186450... |
10,009,862 | Mature cartilage may be expected to contain populations of hypoxic cells as a result of the tissues lack of direct vascularization and structure; it may therefore be at risk from possible radiosensitization. The hypoxic-cell radiosensitizing drug misonidazole Ro-07-0582 (MISO) was administered i.v. to mature New Zealan... | [
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0.1500138789... |
10,009,863 | Modulation of ascites tumour growth by nucleic acids and nucleases. | [
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10,009,864 | Trial of an aromatic retinoid in patients with solid tumours. | [
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-0.02375737... |
10,009,865 | Synergism of chlorpromazine and hyperthermia in two mouse solid tumours. | [
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0... |
10,009,866 | Cimetidine amplifies the anti-neoplastic effect of Trichinella spiralis in mice. | [
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0.03201420232653618,
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0.01663976162672043,
0.0328... |
10,009,867 | Distribution of melanoma on the body surface. | [
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0.024285584688186646,
0.074... |
10,009,868 | Asbestos pleural disease. | [
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0.042432017624378204,
0.09665022790431976,
0.0... |
10,009,869 | The lung function tests on 88 asbestos workers known to have an asbestos-related abnormality on the chest radiography have been analysed with respect to pleural disease. The degree of intrapulmonary and pleural disease were assessed by reading posteroanterior and both oblique films according to a modified ILO U/C Class... | [
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0.028731506317853928,
0.07161662727594376,
0.049346... |
10,009,870 | A new look at adult asthma. | [
0.028376279398798943,
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0.038610175251960754,
0.036196205765008926,
0.01580825448036194,
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0.08012618869543076,
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... |
10,009,871 | Understanding of the natural history of asthma is hampered by the lack of precise definitions. A new definition of severe acute asthma is proposed with primary emphasis on the circulatory disturbances. The natural history of severe acute asthma and the value of steroid therapy are re-examined in the light of the new de... | [
0.02046380750834942,
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0.016286855563521385,
0.09200489521026611,
0.022818442434072495,
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10,009,872 | Acute severe asthma treated without steroids. | [
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0.14244073629379272,
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0.01... |
10,009,873 | Sixty patients with acute severe asthma were treated by conventional methods in all respects except for the use of steroids. Patients who were not currently taking systemic steroids (30) received none during the severe attack, and those who were currently taking systemic steroids (30) were given 400 mg hydrocortisone d... | [
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0.11835738271474838,
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... |
10,009,874 | Does the lung work? 3. Shedding light on the subject. | [
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0.0639999583363533,
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0.10... |
10,009,875 | Lung function in young adults with cystic fibrosis. | [
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0.0452476404607296,
0.0271848663687706,
0.116727046... |
10,009,876 | Pulmonary function tests have been carried out on eight adults with cystic fibrosis. There were statistically significant correlations between the severity of the patient's clinical state as assessed by the Shwachman score and TLco, TLC and VC. In addition the RV/TLC ratio increased with increasing clinical severity. T... | [
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0.023339737206697464,
0.028229955583810806,
-0.03639549762010574,
0.002193373627960682,
0.12... |
10,009,877 | The influence of lung volume on gas transfer in scoliosis. | [
0.04009294882416725,
-0.01769157312810421,
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-0.009091923013329506,
0.016052912920713425,
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0.004840885754674673,
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0.1311037838459015,
0.0585193857550621,
0.08697675... |
10,009,878 | Single-breath carbon monoxide transfer factor (DLCO) and diffusion coefficient (KCO) have been compared with vital capacity and total lung capacity in 119 subjects with scoliosis, 74 with idiopathic scoliosis, 32 with congenital osteogenic scoliosis and 13 with paralytic scoliosis. In each group mean values of DLCO wer... | [
0.07470078021287918,
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0.03942286595702171,
0.042015980929136276,
0.04272821173071861,
0.026803921908140182,
0.0615... |
10,009,879 | Reproducibility of the Tine tuberculin test. Research Committee of the British Thoracic Association. | [
0.057520631700754166,
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0.006577671505510807,
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0.11582768708467484,
0.12... |
10,009,880 | The reproducibility of the tine tuberculin test was assessed by paired tests on 180 subjects. Using the recommended method of measurement, there was lack of agreement in 23%. The discrepancies were reduced to 18% using a different method. There were no examples of a subject with a negative response on one arm and a pos... | [
0.024304037913680077,
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0.04676121473312378,
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0.09083376824855804,
0.... |
10,009,881 | Alcohol in asthma and the bronchoconstrictor effect of chlorpropamide. | [
0.10635337233543396,
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0.058... |
10,009,882 | The effect of drinking 40 ml of sherry on peak expiratory flow rate in 16 normal subjects and 19 patients with asthma was assessed after oral administration of either chlorpropamide or placebo. After placebo and sherry normal subjects showed no change in peak expiratory flow rate, while an increase was usually shown by... | [
0.07702182978391647,
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0.06779740750789642,
0.05236351862549782,
0.053372... |
10,009,883 | Selective bronchography using the fibreoptic bronchoscope. | [
0.12474311143159866,
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0.012850448489189148,
0.061030399054288864,
0.037499841302633286,
0.0... |
10,009,884 | Pulmonary alveolar microlithiasis with an unusual radiological pattern. | [
0.013935592956840992,
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0.07... |
10,009,885 | We present a case of pulmonary alveolar microlithiasis with an unusual radiological pattern in an an otherwise asymptomatic young woman. It was characterized by a reticulonodular pattern predominantly in the lower lung fields with Kerley B lines. The diagnosis was made by transbronchial lung biopsy. We found an otherwi... | [
0.04533830285072327,
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0.025508245453238487,
0.05725971236824989,
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0.04368070513010025,
0.048451... |
10,009,886 | Fleischner's lines-a model? | [
-0.07328977435827255,
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0.055977970361709595,
0.009921703487634659,
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0.017338253557682037,
0.06328220665454865,
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10,009,887 | Multiple cerebral abscesses in an adult with cystic fibrosis. | [
0.003234376199543476,
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0.04950407147407532,
0... |
10,009,888 | Some cognitive components of the diagnostic thinking process. | [
0.15626035630702972,
0.007145872339606285,
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0.030501198023557663,
0.04825134575366974,
0.04259686917066574,
0.0238431692... |
10,009,889 | Chronic dermatophyte infections. I. Clinical and mycological features. | [
0.020740574225783348,
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0.059176310896873474,
0.004002740141004324,
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0.02832009457051754,
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0.008993906900286674,
0.0419... |
10,009,890 | One hundred and six patients with chronic dermatophytosis unresponsive to griseofulvin were studied. Trichophyton rubrum was the causative organism in 93% of cases. Chronic dermatophyte infections caused by organisms other than T. rubrum occurred predominantly, but not exclusively, in patients with underlying diseases.... | [
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0.053526345640420914,
0.016588222235441208,
-0.0358622707426548,
0.03328564018011093,
0.06... |
10,009,891 | Plasma exchange in corticosteroid-resistant pemphigus. | [
0.051652319729328156,
0.0827704444527626,
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0.05957721918821335,
0.04012732207775116,
-0.09450673311948776,
-0.02497940883040428,
0.0298152882... |
10,009,892 | Dapsone and discoid lupus erythematosus. | [
-0.12465688586235046,
0.05699054151773453,
0.016742220148444176,
0.031518466770648956,
-0.00828559324145317,
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0.02628350630402565,
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-0.03230707719922066,
0.008349842391908169,
0.06391506642103195,
-0.0001747478381730616,
0.031... |
10,009,893 | Melanocyte-stimulating hormone (MSH) and skin: proceedings of a symposium held at the BAD Investigative Group Meeting, Cardiff, 24 January 1981. | [
0.027923110872507095,
0.032732702791690826,
0.025212399661540985,
0.09679809957742691,
0.038185130804777145,
0.07985065132379532,
0.08329217880964279,
0.05037945508956909,
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0.06919806450605392,
-0.012384938076138496,
-0.09276355057954788,
-0.0678539127111435,
0.0674481... |
10,009,894 | Formaldehyde sensitivity in patients allergic to formaldehyde-releasing biocides. | [
0.08824501186609268,
0.01860509067773819,
0.035288795828819275,
0.016304370015859604,
0.06995101273059845,
0.03802606835961342,
0.02945874258875847,
0.10207744687795639,
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0.0597551167011261,
0.002707169856876135,
-0.005404207855463028,
-0.0645008236169815,
0.076302878... |
10,009,895 | Scarring of the concha as a sign of lupus erythematosus. | [
-0.0007393258856609464,
0.022725306451320648,
0.06767778098583221,
0.08024833351373672,
-0.011442165821790695,
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0.06625351309776306,
0.0783436968922615,
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0.010239425115287304,
0.04977063089609146,
-0.04519791901111603,
0.06248416751623154,
-0.0232... |
10,009,896 | A long-term hypopigmentary effect of thorium-X on freckled skin. | [
0.045873094350099564,
0.07368924468755722,
0.04485264793038368,
0.06436603516340256,
0.082701675593853,
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0.030485864728689194,
0.07939962297677994,
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0.04019184783101082,
-0.053609397262334824,
0.07228292524814606,
0.029711768... |
10,009,897 | Sixteen years ago, an area on the forearm of a freckled subject was painted with a solution containing 500 esu of thorium-X per ml. Since then, despite much exposure to solar irradiation, there has been a complete absence of freckles from this area, which stands out in marked contrast to the surrounding skin. Biopsy of... | [
0.04376022145152092,
0.07639157772064209,
0.06948380917310715,
0.0717136561870575,
0.05375146493315697,
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0.07887247204780579,
0.04301547631621361,
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0.02536752074956894,
0.032701849937438965,
-0.12066973745822906,
0.00885611493140459,
0.0726507902... |
10,009,898 | Do freckles protect the skin from actinic damage? | [
-0.06560113281011581,
0.06819625198841095,
0.06789686530828476,
0.1035236045718193,
0.06729637831449509,
0.05557886138558388,
0.10425832867622375,
0.08127310127019882,
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0.05145266652107239,
0.028197050094604492,
-0.04039635881781578,
-0.056036800146102905,
0.021195538... |
10,009,899 | Epidermal sunburn (SB) cells were counted 24 h after exposure of the skin to suprathreshold doses of solar simulated radiation. The sites compared were evenly pigmented black skin and freckled white skin. SB cell numbers were dose related in all cases. There were fewer SB cells in black than white skin following equiva... | [
0.0512891560792923,
0.05282502993941307,
0.039982687681913376,
0.03102760948240757,
0.07969412952661514,
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0.1192283183336258,
0.09623865783214569,
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0.019928108900785446,
0.06125740706920624,
-0.04620806872844696,
0.04636174067854881,
0.02705296687... |
10,009,900 | UV-B doses received during different outdoor activities and UV-B treatment of psoriasis. | [
0.05205879360437393,
0.047737494111061096,
0.0258535947650671,
0.0070973969995975494,
0.03326326981186867,
0.06434410810470581,
0.05985076352953911,
0.11698855459690094,
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0.054588500410318375,
0.04211706295609474,
0.005219382233917713,
0.020809533074498177,
0.0767069160... |
10,009,901 | UVR radiometry of solar simulated radiation in experimental photocarcinogenesis studies. | [
0.005719022359699011,
0.03506104648113251,
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0.03983389213681221,
0.10818134248256683,
-0.056076530367136,
0.04613879323005676,
0.0450... |
10,009,902 | The UVR radiometry of a long-term mouse photocarcinogenesis project is described. The methods used were (a) a phototherapy (UV-A) radiometer, (b) an electronic integrating dosimeter, (c) indirect spectroradiometry and (d) polysulphone and phenothiazine film badges for UV-B and UV-A respectively. The merits of the vario... | [
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0.02414354681968689,
0.09059270471334457,
-0.010447037406265736,
0.023779384791851044,
0.... |
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