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Influence of genital heat stress on semen quality in humans. The concept that an elevation of testicular temperature results in impairment of spermatogenesis is widely accepted. Here, current knowledge concerning genital heat stress and its consequences in men is reviewed. Duration of sitting during work positively correlates with daytime scrotal temperatures and daytime scrotal temperature negatively correlates with semen quality. However, the assumed negative correlation between duration of sitting and semen quality could not be shown in the available studies. Fertility parameters of professional drivers with long periods of sitting in vehicles were impaired; however, for predominantly affected drivers of vans, trucks or industrial heavy machinery potential confounders have to be considered. Wearing tight fitting compared with loose-fitting underwear is associated with significantly higher scrotal temperatures. However, available observations suggesting a link between tight-fitting underwear or trousers and impaired semen quality are not convincing. Studies addressing professional exposure to high temperatures delivered conflicting results concerning fertility parameters. The postulated negative impact of sauna visits on semen quality is not sufficiently underlined by the available studies. Oligozoospermic men with a varicocele have significantly higher scrotal temperatures than normozoospermic men, and according to several studies varicocelectomy normalises scrotal temperatures. A further link has been reported between fever and deteriorated semen quality. Contraception via genital heat stress has been demonstrated using hot sitting baths or insulating suspensors. However, down-regulation of spermatogenesis is inconsistent and unsafe. On the other hand, scrotal and consecutively testicular cooling is able to improve semen quality.
{ "pile_set_name": "PubMed Abstracts" }
The Stranglers rocker JEAN-JACQUES BURNEL blames a fight he had with The Clash bassist PAUL SIMONON for almost wrecking his band's career in the mid-1970s. Bass player Burnel and Stranglers keyboardist DAVE GREENFIELD both became involved in a brawl that turned the British music press against them. Burnell says, "In 1976, when we supported the Ramones, I had a punch-up with Paul Simonon from The Clash, and that was seen by everyone. "Dave had John Lydon (Sex Pistols frontman JOHNNY ROTTEN) up against a transit van, while (The Clash frontman) Joe Strummer and (The Stranglers guitarist) HUGH CORNWELL stood at the side, saying, 'I think your bass player is having a thing with my bass player.' "Ever since that, the press were against us. Those journalists are dead or retired and the people reviewing our records now don't know about all that b**locks."
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Once you select us to obtain your home loan, you'll be amazed at how quickly and simply the loan process moves. Before you know it, you'll have a mortgage that suits your lifestyle and saves you money. Throughout the loan-application process, we provide you with regular updates. You can also e-mail us with questions or new information. And if you want assistance, a mortgage expert who can answer questions is just a phone call away. Here's an overview of the loan-application process STEP ONE -- Be Prepared When you've decided to buy a home or refinance your current home click one of the links on the left to fill out our Got A Minute application or you can request a free consultation. STEP TWO -- You are Pre-Approved! You can now go searching for the perfect home for you. Once you have a signed contract make sure to get it to us as soon as possible. We will work with you and your realtor to ensure a smooth and successful home loan process. Keeping it simple and LOCAL for your benefit. Reasonable costs, quick processing and closings.
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Q: Decomposition of $sl_2(\mathbb{C})$ Let $L = sl_2(\mathbb{C})$. We call $L = H_0 \oplus H_1 \oplus H_2$ an $orthogonal \ decomposition$ if all components $H_i$ of decomposition are Cartan subalgebras and pairwise orthogonal with respect to the Killing form. Now, suppose that $H_0$ is a Cartan subalgebra consisting of the diagonal matrices and $H_1$ is another Cartan subalgebra orthogonal to $H_0$ via the Killing Form. One can check easily that $H_1$ has a basis of the form: $H_1 = \Big < \begin{pmatrix} 0 & 1 \\ a & 0 \end{pmatrix} \Big >_\mathbb{C}$ for some $a \neq 0$. Thus, $L = H_0 \oplus \Big < \begin{pmatrix} 0 & 1 \\ a & 0 \end{pmatrix} \Big >_\mathbb{C}\oplus \Big < \begin{pmatrix} 0 & 1 \\ b & 0 \end{pmatrix} \Big >_\mathbb{C}$ for some $a, b \neq 0$. Can we prove that either $a$ or $b$ (from above) must be $1$ in order to have the orthogonal decomposition? Or they don't have to be. If the answer is negative, can we still show that for each $a \neq 0$, there exists an automorphism $\phi \in Aut(L)$ such that $\phi(H_0) = H_0$ and $\phi(\begin{pmatrix} 0 & 1 \\ a & 0 \end{pmatrix}) = \begin{pmatrix} 0 & 1 \\ 1 & 0 \end{pmatrix}$? Note that the Killing form can be given by $K(A, B) = 4Tr(AB)$ for all $A, B \in sl_2(\mathbb{C})$. A: The orthogonal complement of $H_0$ in $\mathfrak sl_2$ with respect to the killing form is $$\{\begin{pmatrix} 0 & a \\ b & 0 \end{pmatrix} : a, b \in \mathbb{C} \}$$ and as you mentioned if you want to decompose the two dimensional space $H_0^{\perp}$ into a direct sum of Cartan subalgebras $H_1 \oplus H_2$, then you're forced to have $H_1 = \langle \begin{pmatrix} 0 & 1 \\ a & 0 \end{pmatrix} \rangle, H_2 = \langle \begin{pmatrix} 0 & 1 \\ b & 0 \end{pmatrix} \rangle$ for distinct, nonzero $a, b$. If you want $H_1, H_2$ to be orthogonal, then you just need the trace $\begin{pmatrix} 0 & 1 \\ a & 0 \end{pmatrix} \begin{pmatrix} 0 & 1 \\ b & 0 \end{pmatrix} = \begin{pmatrix}b & 0 \\ 0 & a \end{pmatrix}$ to be zero. So neither $a$ nor $b$ has to be one; you just need $a = -b$. For your question about the automorphism, I think the answer is no. I believe every Lie algebra automorphism of $\mathfrak{sl}_2$ is the differential of an automorphism of algebraic groups of $\textrm{SL}_2$. Every automorphism $\phi$ of $\textrm{SL}_2$ is know to be inner, say $x \mapsto gxg^{-1}$ for some $g \in \textrm{SL}_2$. The differential $d\phi$ of such an automorphism is given by the same formula: $X \mapsto gXg^{-1}$. In order for $d\phi$ to fix $H_0$, $\phi$ has to fix the standard torus in $\textrm{SL}_2$, which means $g$ needs to be in that torus: so $g = \begin{pmatrix} c \\ & \frac{1}{c} \end{pmatrix}$. From here you can see that what you want is impossible.
{ "pile_set_name": "StackExchange" }
Speed Drawing - youtu.be/UYQ9bEHc9lY This drawing took longer to make than I though it would. I was really busy last week, and it took a long time to get this picture done. I do like the way it turned out, though.Isabelle is (c): Nintendo
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Charlie Moran played in the majors in 1903 and again in 1908, appearing in 16 games at catcher, 3 at pitcher and 1 at shortstop. He coached Texas A&M University from 1909-1914 and was also a National Leagueumpire from 1918 to 1939. Charlie played many years in the minors and also managed at least five seasons. He is not to be confused with Charles Moran, who was also in the majors at the same time. The way that Sporting Life dealt with the two was to describe Charles as "Charlie Moran the shortstop", or "Charlie Moran the second baseman" or "Charlie Moran the Georgetown boy", while the other fellow was "Charlie Moran the catcher". Either one could be referred to as "Charley" rather than "Charlie". Other Morans added to the possible confusion - the Sporting Life issue of October 25, 1902, believed that a story about Charles possibly going to play with Boston appeared because some writer had confused Charles with Pat Moran, a Boston catcher in 1902. Although he was called Charlie the catcher, Moran did some pitching during his early years in the minors (and in the majors). He was 10-7 in 1902. He also appears to have played primarily first base in the minors in 1903.
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Unfortunately for the people of the world everything is going according to the New World Order Plan. But what is this New World Order Plan? In a nutshell the Plan is this. The Dark Agenda of the secret planners of the New World Order is to reduce the world's population to a "sustainable" level "in perpetual balance with nature" by a ruthless Population Control Agenda via Population and Reproduction Control. A Mass Culling of the People via Planned Parenthood, toxic adulteration of water and food supplies, release of weaponised man-made viruses, man-made pandemics, mass vaccination campaigns and a planned Third World War. Then, the Dark Agenda will impose upon the drastically reduced world population a global feudal-fascist state with a World Government, World Religion, World Army, World Central Bank, World Currency and a micro-chipped population. In short, to kill 90% of the world's population and to control all aspects of the human condition and thus rule everyone, everywhere from the cradle to the grave. British-Israelism (also called Anglo-Israelism) is a composite of religious doctrines, first elaborated in 18th century England, whose common theme is that some ancient British people and/or royal lineages are direct lineal descendants of some of the Ten Lost Tribes of Israel. Thus, British-Israelism was founded upon the claim that the English Anglo-Saxons were one of the Ten Lost Tribes of Israel. Moreover that the British monarch was the direct descendant of King David, were of the Davidic Bloodline, and so, heir to"the throne of King David."In short, the British were the true Israelites and therefore"God's Chosen People."Moreover, by extension, that the Israelites of the Bible are not the modern Jews, but, rather, today's Anglo-Saxons. These belies have spawned the Christian Identity movement. British-Israelism relies upon the belief that large numbers of the Ten Tribes of Israel living in the Northern Kingdom of Israel were deported by Sargon, king of Assyria, on the fall of its capitol, Samaria, to him in 721 BC (2 Kings 17:5). After the downfall of the Northern Kingdom, the people were transported wholesale by the conqueror causing a massive depopulationof the land such that: "... the king of Assyria brought men from Babylon, and from Cuthah, and from Avva, and from Hamath and Sepharvaim, and placed them in the cities of Samaria instead of the children of Israel; and they possessed Samaria, and dwelt in the cities thereof"(2 Kings 17:24). Thus, the Northern Kingdom of Israel was conquered its people removed and replaced by non-Israelites: that is, the depopulation and re-population of Samaria. That during various episodes of deportation and re-population in connection with the subjugation of the Northern Kingdom the Ten Northern Tribes of Israel were taken into captivity, to Assyria, and subsequently lost to history; and so, become known asthe Ten Lost Tribes of Israel. However, although lost to the historian, the belief that the Ten Lost Tribes were distinct and maintained their identity after the Assyrian captivity is an old idea appearing in various ancient sources. For instance, in the second century BC in the apocryphal Book of Tobit whose eponymous hero is a member of the tribe of Naphtali, "who in the days of Shalmaneser, king of the Assyrians, was taken into captivity from Thisbe." And, in the pseudepigraphal 2 Baruch, produced in the latter half of the first century AD in which the author claims to be Baruch, the secretary of Jeremiah (Jer. 36:4) and begins a letter "to the nine and a half tribes, which were across the river Euphrates." And also the apocryphal work 2 Esdras from the same period in which: "These are the ten tribes which were led away from their own land into captivity in the days of King Hoshea, whom Shalmaneser the king of the Assyrians led captive; he took them across the river, and they were taken into another land. But they formed this plan ... that they would ... go to a more distant region, where mankind had never lived ... [to] Azareth." And even Josephus (1st century AD) mentions the Ten Tribes in his Antiquities: "Wherefore there are but two tribes in Asia and Europe subject to the Romans, while the ten tribes are beyond the Euphrates till now, and are an immense multitude, and not to be estimated by numbers" Even Jerome (347-420), one of the great fathers of the early Christian Church writing in the fifth century AD, believed the Ten Tribes were still in the land of their captivity. However. the first public appearance of the theory of the glorious heritage, which belongs to the British, emerged in the 1700s during the religious climate of Millenarianism and especially in the preaching and writings of two men, Richard Brothers (1757-1824) and John Wilson (1788-1870) In 1793, Richard Brothers declared himself the"revealed Prince and Prophet" of The Lost Ten Tribes of Israel, the lost"Jews" who were hidden amongst the population of Great Britain. Brothers let it be known that he was the apostle of a new religion and his special role was the gathering of the "Jews" back into the Promised Land of Israel. Moreover, that the "hidden Israel" settled amidst the other pagan tribes of Europe were the true Biblical "Jews" lost to history. And, since they had no notion of their cherished lineage, it was his special role to make it known to them and then lead them back to the land of Canaan. In fact, the mentally unstable Brothers not only proclaimed himself to be "Prince of the Hebrews" and so the literal descendant of the Biblical House of David but also the "Nephew of the Almighty" -"Ruler of the world"- who would rule over Israel until the return of Jesus Christ. All done, said Brothers, using a rod fashioned from a wild rosebush with which he would perform miracles similar to those Moses had performed. It was from this inauspicious start that arose the powerful modern British-Israel Movement. Whereas Brothers could claim to be the first in print it was Rev. John Wilson's Lectures onOur Israelitish Origins (1840) underpinned by Scripture, historiography, logic and reason that put British-Israelism on firmer footing. Wilson seemingly established the Israelitish origin of the Anglo-Saxons bytracing the migrations of the peoples of Israel as they made their way across the continent of Europe to the British Isles. Wilson's hypothesis was that The Lost Ten Tribes of Israel taken captive by the Assyrians in the 721 BC had migrated north and west and had been assimilated into the pagan cultures of Europe and especially the Anglo-Saxons that settled in Britain. Consequently, Great Britain is the geographical home of The Lost Ten Tribes of Israel and thepeople of Anglo-Saxon descent are heirs of the Covenant Promises made to Israel by Yahweh in the Old Testament. Thus, according to Wilson and his followers, British-Israelisms affirms both the proper identification of The Lost Ten Tribes of Israel and proper application of biblical prophecy as directed to Anglo-Saxons specifically. Thus, its Anglo-Saxon advocates established a unique relationship with Yahweh and, therefore, the British people became the world's elite and in receipt of the rewards and privileges associated with this lofty status vis-à-vis a World Empire. Wilson's successor was Edward Hine (1825-91) who enthusiastically took up the cause claiming to have addressed five million people on this theory during his lecture-circuit career in Britain and in the United States. Hine wrote Forty-Seven Identifications of the British Nation With Lost Israel (1871) and edited a magazine called The Banner of Israelin which he introduced one of his most important teachings was pyramidism: the belief in a divine source behind the construction of the Great Pyramids of Egypt with its own superior form of measurement. Moreover, Hine believed that the future can be revealed if these superior measurements of the inner tunnels of the Great Pyramid of Giza are correctly interpreted. Thus, Hine introduced sacred geometry and superior mathematics of the pyramids into the romance of British-Israelism. His theory of pyramidism was eagerly taken up by others in the British-Israel Movement who also viewed the pyramids and their sacred geometry as a tool whereby God's Will for the future could be discerned. Hence: "... the region in which granite reappears, after being wholly absent for an interval of near 2,900 inches [represents] the years during which the two houses of Israel and Judah have remained separate..." Jane Simpson: The Journal of the British-Israel Association (July 1907) This, then, is the romance of the Ten Northern Tribes of Israel, apparently lost from the pages of history, which in a nutshell is this: that the Anglo-Saxons are the physical descendants of the Israelites and that Great Britain with her daughter the United States of America has inherited all the Covenant Blessings given to Abraham by Yahweh. That, these two English-speaking nations that changed the world are the two nations who are in receipt of Yahweh's commitments to Abraham and his descendants (Gen. 12:1-3; 17:5). Moreover, that persuasive mass of Biblical passages, ancient texts, linguistics arguments, pyramidism and legends are offered as proof of the theory. Theologically, the movement did not regard its esoteric truths as incompatible with the established denominations and so never regarded itself as a cult or sect and so never took sectarian form. However, lacking hierarchy and an organisational centre, the movement's disparate threads and characters inevitably developed increasingly fantastic ideological and theological scenarios unchecked by any recognised centre of Christian orthodoxy. And, this enthusiasm for the theory was seen especially in America. British-Israelism was a theory and movement that, in Britain, peaked in the 1920s and has been in decline ever since, but, one that found fertile ground in America in the Depression Era of the 1930s. Howard B Rand (1889-1991) founded the Anglo-Saxon Federation of America in 1930 with the help of Wesley Swift who later founded his own church, called the Church of Jesus Christ Christian, which developed into the Aryan Nations. These two men laid the foundations of the so-called Christian Identity Movement or simply the Identity Movement. This was a logical extension of the theory propounded first by the British that they were the true Israelites and so true heirs of the Abrahamic Covenant. Rand and Swift argued that if this was the case then the modern Jew's claim to the Covenant was false. From this arose the doctrines of a modern movement that opposed the claim ofmodern Jews to everything pertaining to Biblical Promisesgiven by Yahweh to the Ancient Israelites. This movement became increasingly defined by this claim and by its intrinsic racial argument. Critics of British-Israelism argue that not only is it a false doctrine its tenets are not without peril with its most patent danger being the ease with which it appears to justify and foster racial pride and racial prejudice vis-à-vis the supposed supremacy of the Anglo-Saxon race as proof that they are The Lost Ten Tribes of Israel andYahweh's "chosen people." Hence, the central thesis of Christian Identity is that whites, not modern Jews, are the true Biblical Israelites favoured by Yahweh. Its more zealous adherents also argue that modern Jews are biologically descended from Satan, while non-whites are soulless"mud people"created with the other Biblical"beasts of the field."In short: the bitter critics of the Christian Identity Movement accuse it not only of sophistry but also of latent racism and crude "anti-Semitism." Thus, these critics claim, with the advent of the North American form ofBritish-Israelism as taught by Brand and his creed "anti-Semitic teachings" and an exclusionary hatred claimed legitimacy for the first time in the movement's history. Thus, critics argue that although Christian Identity roots are in the 19th century British-Israelism, a theory which was initially friendly to Jews, but was adopted and transformed in the 20th century by a number of "racist preachers" in the United States into a rabidly anti-Semitic creed. Furthermore, that the Identity Theory has been one of the most important ideologies underpinning the so-called White Supremacist Movement, which in the crudest form is this: Christ will only return to Earth when it is racially cleansed of Jews. A doctrine described by W A Redding in his book, The Millennial Kingdom: A Book of Surprises (1894) "I shall therefore take a shorter route through the subject by calling your attention to some facts, as they exist, which will convince you, without history, that the Anglo-Saxons are the Lost Ten Tribes of Israel. Go over the earth and collect together all the Anglo-Saxon people and put them in a bunch to themselves; then collect together all the other races of people, such as the Chinese, Japanese, Egyptians, Hindoos, Malays, Negroes, Indians, Arabians and many other kinds of human beings, and put them all together in a bunch to themselves. Then compare the one congregation with the other. In the Anglo-Saxon bunch you will see high foreheads, long, slim, intellectual noses, brilliant eyes, fine texture of the skin, well-proportioned physical frames and fine, smooth hair. Turn to the other group of races. There you will see the low, flat foreheads, heavy, short, thick noses, vicious eyes, coarse hair, and uncomely features." And on the question of the Jew: "God designated one part as Israel and the other part as Judah, and this part called Judah are the Jews we see on our streets to-day, and we can pick them out by their looks, as the Bible tells us that God marked their faces so we can tell them anywhere, so that they can be persecuted for killing Christ." British-Israelism can thus lead to its adherents to teach, at least by implication, Salvation by Race as well as by Grace. British-Israelism was originally not an "anti-Semitic" doctrine since its advocates typically viewed the modern Jews as legitimate descendants of Israel together with the Anglo-Saxon peoples. Moreover, today not all British-Israelites today are "anti-Semitic," nor are they all part of the Christian Identity Movement.
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Q: How to send message to JMS server from one machine and receive that from another machine in JBoss 7 I am trying to send message(TextMessage) to JMS server from my laptop, then I am trying to receive that message from another laptop. I am using JBoss AS 7.1. My both laptops are connected in same network. When I am doing that I am getting exception. I searched for this in google and some is saying that in JBoss 7.1 JNDI will not get connections from remote IP's and they are saying that we have to use HornetQ. Can any one please help in this issue. A: Looks like you have two queues, one on each machine. They only have the same name, but are not connected in any way. You could make the sender machine use the remote queue directly, but it's advisable to use (like you have) two queues instead, one on each node, and then configure a bridge to move the messages from one to the other. In this way, sending as well as receiving messages will work within your local transactions, which is what you'll normally want. In order to configure the bridge, HornetQ offers two options: A generic JMS bridge, and a core bridge. The former is generic, as it can bridge between JMS queues of any JMS provider. But the HornetQ docs recommend core bridges when using HornetQ on both sides, as they are faster and more robust. The JBoss docs (the section "JMS Bridge"), describes the setup for a JMS-Bridge using the CLI. The HornetQ docs for core bridges describes the stand alone setup (outside of the JBoss server); converting that to CLI, you'll get (replace the parts in curly brackets with your values): /subsystem=messaging/hornetq-server=default/bridge={bridge-name}:add(queue-name="{queue-name}", forwarding-address="{remote-hostname}", static-connectors=["http-acceptor"]) To see a brief description of all parameters, use this command: /subsystem=messaging/hornetq-server=default/bridge=x:read-resource-description
{ "pile_set_name": "StackExchange" }
Backpacking in Argentina – my Argentina Travel Guide My Argentina Travel Guide helps you to plan your trip to Argentina and explore the most incredible places this country has to offer from Salta in the north down to Ushuaia in the very south. Beside useful information on how to prepare I sum up practical tips on things to do, accommodations and outdoor activities you shouldn't miss. Backpacking in Argentina: My Argentina Travel Guide is a clear and concise 100 page eBook based on my experience from more than 3 months traveling through Argentina. This ebook includes travel guides for the several regions of Argentina as well as a tiny trekking guide for El Chaltén and Ushuaia (route itineraries for recommended hikes). Checklists are included to help make sure you don’t forget anything. This eBook is designed to save you a lot of time & make your trip much easier. Buy Now & Download Immediately You can easily purchase this eBook through Amazon for your Kindle or any other electronic device such as your PC/Mac, Smartphone or Tablet (you only need the free Kindle App). After the purchase you can download the eBook and take it with you wherever you go!
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Q: How to showing value on dropdown list form auto select value from database i have a from to edit/ update data . on colomn input like name ,email ,date i dont have a problem because this value can e displayed at this colomn like this : <div class="item form-group"> <label class="control-label col-md-3 col-sm-3 col-xs-12" for="nama">NAMA <span class="required">*</span> </label> <div class="col-md-6 col-sm-6 col-xs-12"> <input id="nama" type="text" class="form-control @error('nama') is-invalid @enderror" name="nama" value="{{$pns->users->nama}}" required autocomplete="nama"> @error('nama') <span class="invalid-feedback" role="alert"> <strong>{{ $message }}</strong> </span> @enderror </div> </div> this value on this input is value="{{$pns->users->nama}}" and its still working , but how i can do this on this input ? this input is select dropdown list like this : <div class="form-group"> <label class="control-label col-md-3 col-sm-3 col-xs-12">Agama <span class="required">*</span></label> <div class="col-md-6 col-sm-9 col-xs-12"> <select name="agama_id" id="agama_id" class="form-control"> @foreach($agama as $masters => $agamas ) <option value="{{ $masters }}">{{ $agamas }}</option> @endforeach </select> </div> </div> where i can user this value like {{$pns->users->nama}} ??? if i open this update form , its will choose automaticlly like this db ?? someone have solution ? A: Try this. <select name="agama_id" id="agama_id" class="form-control"> @foreach($agama as $masters => $agamas ) <option value="{{ $masters }}" @if ($pns->users->agama_id == $masters ) selected @endif>{{ $agamas }}</option> @endforeach </select>
{ "pile_set_name": "StackExchange" }
Spectroscopic investigation of ligand interaction with hepatic phenylalanine hydroxylase: evidence for a conformational change associated with activation. We have examined the interaction of phenylalanine hydroxylase with phenylalanine, tetrahydropterin cofactors, and an activating phospholipid, lysophosphatidylcholine. Incubation of native phenylalanine hydroxylase with phenylalanine or lysophosphatidylcholine results in an increase in the fluorescence emission of the enzyme at 360 nm, which closely parallels the increase in tetrahydrobiopterin-dependent activity observed under these conditions. The presence of tetrahydrobiopterin in the absence of phenylalanine results in quenching of the enzyme fluorescence emission; this quenching exhibits a sharp end point at about 1 mol of tetrahydrobiopterin bound/mol of enzyme subunit. The binding of tetrahydrobiopterin under these conditions is unexpectedly tight, with an estimated KD of 10-20 nM, while in the presence of lysophosphatidylcholine, the KD is increased to about 25 microM. Quenching experiments with sodium iodide indicate greater exposure of tryptophan residues in the phenylalanine-activated enzyme. The ultraviolet difference spectrum of phenylalanine hydroxylase in the presence of phenylalanine exhibits a peak at 238 nm, which correlates with the fluorescence increase and activation, as well as additional changes in the aromatic region, which do not correlate well with activation. Phenylalanine does not alter the far-ultraviolet circular dichroism spectrum of phenylalanine hydroxylase. In contrast, lysophosphatidylcholine appears to induce a dramatic change in enzyme secondary structure upon activation. These results suggest that activation of phenylalanine hydroxylase results in a conformation change and the exposure of buried tryptophan(s) and possibly a cysteine residue.
{ "pile_set_name": "PubMed Abstracts" }
APTA Language Reflected in Senate Appropriations Bill APTA has successfully secured report language in appropriations legislation specific to rehabilitation research and physical therapy issues recently passed by the US Senate Committee on Appropriations. The association's recommendations for language are well-represented, many times verbatim, in the Fiscal Year 2012 appropriations bill for the departments of Labor, Health and Human Services, Education, and related agencies. While this language is nonbinding statutorily, it specifically indicates the priorities of the Senate in the amounts of federal funding it has allocated to specific agencies. The report language includes APTA's recommendation "… to build a sustainable infrastructure and capacity of emerging scientists in rehabilitation research …" and encourages "awards for emerging scientists, such as physical therapists, to meet this need." The legislation also calls for the Agency for Healthcare Research and Quality to seek opportunities to collaborate with the Centers for Medicare and Medicaid Services and the National Center for Medical Rehabilitation Research within the Eunice Kennedy Shriver National Institute for Child Health and Human Development. Such a partnership, APTA suggested, "can advance potential opportunities to conduct comparative investigations of rehabilitation interventions with other health care treatment approaches." Overall, the Senate bill finances many programs important to physical therapy at levels near 2011 funding. However, the committee acknowledges its inability to fund certain agencies at their requested amounts, specifically the National Institutes of Health (NIH). "With tight budgets likely to continue for the foreseeable future, the committee strongly urges NIH to explore creative ways to rethink the way it allocates its funding."
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Q: hard code custom field for custom post type in wordpress I have created a custom post type in wordpress called videos. When the admin adds a video he also needs to provide a youtube-id. This can be done by selecting the appropriate custom field from the drop-down list and then entering the ID. I was wondering though, isn't there a way to always display that custom field when you are adding or editing a video? (And optionally, could you even make it a required field?) A: I'll just answer my own question after 8 years :) For people who live on another planet: just use the ACF plugin
{ "pile_set_name": "StackExchange" }
Case studies: a research strategy appropriate for palliative care? Selecting an appropriate research strategy is key to ensuring that research questions are addressed in a way which has value and is congruent with the overall topic, questions and purpose of the research. This paper will argue that there are situations when a case study strategy is appropriate to use in palliative care research. These include: when complex situations need to be addressed; when context is central to the study; when multiple perspectives need to be recognized; when the design needs to be flexible; when the research needs to be congruent with clinical practice; when there is no strong theory to which to appeal; and when other methodologies could be difficult to conduct. Using case study strategies rigorously and appropriately can contribute to knowledge in a way which is sensitive to the complex, context-dependent and multiprofessional nature of palliative care.
{ "pile_set_name": "PubMed Abstracts" }
Introduction {#Sec1} ============ In Europe, on average 70% of total expenditure on dental care is private expenditure and 16% of this private expenditure is covered by complementary dental insurance (CDI) \[[@CR1]\]. However, most CDI products currently on the market in Belgium, France, Germany, and the Netherlands are not optimal because (1) they provide little protection against financial risk and do not improve access to otherwise unaffordable dental treatment (e.g., implants and crowns) and (2) moral hazard and adverse selection are not sufficiently counteracted. The suboptimal character of CDI can be explained by supply-side aspects (the limits of insurability) and demand-side aspects (behavioral economics). On the basis of these potential explanations, strategies will be drawn to optimize dental insurance. We begin by presenting a framework for optimal insurance design, as well as the current situation of CDI in Belgium, France, Germany, and the Netherlands. Optimal health insurance design {#Sec2} =============================== Health insurance has two important advantages for the consumer, but also two disadvantages (see Table [1](#Tab1){ref-type="table"} below). On the one hand, health insurance reduces the financial risk for the insured and provides access to health care that would otherwise be unaffordable \[[@CR2]\]. On the other hand, insurance increases costs due to loading costs---the administrative and other expenses of the insurer---and moral hazard. In relation to dental care, perhaps more so than in relation to other types of care, a choice is possible between cheaper basic treatments and more expensive 'luxury' treatments (e.g., placing a metal crown versus a porcelain crown), which may result in substantial moral hazard (both consumer- and supplier-induced moral hazard).Table 1Advantages and disadvantages of health insuranceAdvantagesDisadvantagesReduction of financial risk for the insuredLoading costsAccess to health care that would otherwise be unaffordableMoral hazard Optimal health insurance should maintain the advantages and reduce the disadvantages as much as possible. First, it should reduce the insured's financial risk as far as possible. Because trivial risks lead to losses that can be borne by the insured without any noticeable burden, optimal insurance should not provide coverage for trivial risks. This avoids relatively high administrative expenses and loss settlement costs (loading costs) that are very high for these risks compared with the pure risk premium. Secondly, optimal insurance should provide 'access to health care that would otherwise be unaffordable'. This implies that cover limits should be avoided and expensive care should be covered as much as possible. Third, the optimality of CDI can be increased by restricting the loading costs of dental insurance by increasing insurers' efficiency. Fourth, to reduce moral hazard, optimal insurance should involve cost-sharing arrangements such as deductibles and co-insurance, and apply managed care. A deductible makes the enrollee responsible for all costs up to a defined threshold. A co-insurance rate makes the enrollee responsible for a percentage of costs. Optimal insurance contracts should also have a stop-loss, a limit on out-of-pocket expenses \[[@CR3]\]. Fifth, optimal insurance should also counteract adverse selection as much as possible. Adverse selection occurs when the insured knows more information about his expected losses than the insurer knows or uses in his premium setting and underwriting process. Adverse selection can be counteracted by selective underwriting (using medical questionnaires), risk rating (setting higher premiums for groups presenting high risk, e.g., age-related) and product differentiation (designing benefits so to attract lower risks). The features of optimal health insurance are summarized in the first column of Table [4](#Tab4){ref-type="table"}. Complementary dental insurance in Belgium, France, Germany, and the Netherlands {#Sec3} =============================================================================== Complementary dental insurance (CDI) provides coverage for care that is either not covered or not fully covered by the mandatory basic insurance (MBI). In the four countries studied, private expenditure on dental care (i.e., not covered by MBI) expressed as a percentage of total expenditure on dental care ranges between 30% in Germany and 74% in the Netherlands (Table [2](#Tab2){ref-type="table"}). CDI represents 3% (Belgium) to 55% (Netherlands) of total expenditure on dental care. Out-of-pocket expenditure on dental care is the highest in Belgium (42%) and the lowest in the Netherlands (19%).Table 2Dental care: expenditure and insuranceBelgiumFranceGermanyNetherlandsAverage expenditure per person on dental care€150€160€314€179Private expenditure (i.e., not covered by MBI)^a^45%65%30%74%Complementary dental insurance (CDI)^a^3%^b^43%5.4%55%Percentage of population with CDI5%95%18%62%Source: \[[@CR1]\]^a^As share of total expenditure on dental care^b^Authors' estimate The coverage provided by CDI is complementary to that provided by MBI, which covers 26% (the Netherlands) to 70% (Germany) of total expenditure on dental care. Table [3](#Tab3){ref-type="table"} provides an overview of the dental care covered by MBI in the four countries.Table 3Dental care covered by mandatory basic health insuranceBelgiumFranceGermanyNetherlandsConservative care (e.g., fillings)+++^a^+++^a^++++^b^Orthodontics (e.g., braces)++++−Prosthetics (e.g., implants, bridges, crowns)−++−Periodontics (gum disease treatment)++++−+++: good coverage++: medium coverage+: low coverage−: no coverage^a^Extra billing is possible^b^Conservative dental care is covered for children only (under age 18) No optimal dental insurance {#Sec4} --------------------------- Currently, CDI offered in Belgium, France, Germany, and the Netherlands cannot be described as 'optimal' (Table [4](#Tab4){ref-type="table"}). German CDI responds best to the criteria of optimal health insurance.Table 4Complementary dental insurance: presence of features of optimal health insurance designBelgiumFranceGermanyNetherlandsNo upper limit on coverage−−+−No coverage of trivial risks−−−−Deductible−−−−Co-insurance+−++Cap on out-of-pocket expenses−−−−Selective underwriting−^a^−^a^+−^a^Risk rating++++Product differentiation++++Managed care−+++−: The feature is not present in CDI products offered+: The feature is present in CDI products offered^a^Selective underwriting is applied only for a limited number of contracts, i.e., those with the highest upper limits on coverage Only in Germany are there no upper limits on coverage for dental care (after an initial period). CDI in the other three countries does not provide access to otherwise unaffordable health services and protection against unpredictable high financial risks. For example, replacing four teeth by implants and crowns can cost about €10,000. Upper limits of only €250 (the Netherlands) or €1000 (Belgium) do not provide protection against high financial risks nor do they make this kind of dental care more accessible. In France, even the most extensive complementary covers provide a maximum amount of only €750 per year for implants. With total costs for an implant easily amounting to about €2500, €1750 still needs to be paid for out-of-pocket after complementary insurance has kicked in. In all four countries, CDI provides coverage of trivial risks. In all four countries, cost sharing is applied, but only in the form of co-insurance. Co-insurance rates vary between 0 and 50% in Belgium, 0 and 55% in Germany, and 0 and 25% in the Netherlands. In France, co-insurance is generally not used. In Germany and the Netherlands, many products are offered with 0% co-insurance. Deductibles are not used. Caps on out-of-pocket expenses, which protect the consumer against high financial risk, are not applied in any of the four countries studied. Selective underwriting is primarily used in Germany, and to a lesser extent in the other three countries. In Belgium, selective underwriting is used by only one insurer offering CDI. In France, where a 7% tax has to be paid for contracts that apply selective underwriting, most CDI contracts abstain from selective underwriting. In Germany, a medical questionnaire needs to be filled out for most CDI products. The insurer can decline to cover the candidate or charge an additional premium or exclude missing teeth or the use of certain techniques from the scope of coverage. Insurance products without selective underwriting usually have contractual clauses excluding reimbursement for problems that existed well before the start of the contract and for treatments running at the moment of the conclusion of the contract ('pre-existing conditions'). In the Netherlands, selective underwriting is rarely applied (only for the high-end dental coverage). In all four countries, risk rating and product differentiation are used to a certain extent (e.g., age-related premiums). Products are designed and marketed to attract certain market segments. In all countries except Belgium, preferred provider networks are used as an element of managed care for CDI. In all countries, waiting times are used as a means to contain costs and to counteract adverse selection. Why is dental insurance suboptimal? {#Sec5} =================================== Both supply-side aspects (the limits of insurability) and demand-side aspects (behavioral economics) may explain why dental insurance is not optimal. Limits of insurability {#Sec6} ---------------------- A potential explanation of why insurers offer suboptimal CDI is that optimal CDI exceeds the limits of insurability. According to Berliner \[[@CR4]\], risks properly belong in the area of insurability where: (1) losses occur with a high degree of randomness; (2) the maximum possible loss for the insurer is limited; (3) the average loss amount upon loss occurrence is small; (4) the average time interval between two loss occurrences is small (i.e., losses occur frequently); (5) the insurance premium is sufficiently high; (6) there is virtually no possibility of moral hazard; (7) coverage of the risk is consistent with public policy; and (8) the law permits the cover. Public policy (7), moral hazard (6), the degree of randomness of losses (1) and the maximum possible loss (2) are important issues as far as the suboptimality of CDI is concerned. Public policy plays an important role in Belgium, France, and the Netherlands, where the 'solidarity' principle is paramount in health care financing. Equal access to health insurance is at the heart of the values of the mutual insurers ('mutuelles') established in those countries. Their goal is to organize solidarity between their members for the reimbursement of health care costs. According to the French 'Code de la mutualité', medical questionnaires may not be used by mutuals and thus selective underwriting cannot be applied. The solidarity idea is not restricted to mutuals. In France, for instance, a 7% tax is due when selective underwriting is applied. So, commercial insurance companies are encouraged by the French government not to apply selective underwriting. In Belgium as well, the government intervenes in the organization of CDI. Premium increases for existing clients are strictly regulated. Premiums can only be adjusted in line with the consumer price index or a specific 'medical index' for dental care, which is calculated annually by the Ministry of Economic Affairs. Fear of reputational damage and the wish to avoid (further) restrictive regulation being adopted may help to explain why (commercial) insurance companies in Belgium, France, and the Netherlands refrain from applying 'hard insurance logic' such as selective underwriting. By offering limited coverage, which is equally accessible for all citizens, insurers willingly refrain from applying private insurance logic. Rather, they apply 'social security mechanisms' (open enrolment, no selective underwriting, community rating). Insurance companies may be concerned that the unfettered application of insurance logic could provoke a reaction from the regulator. In a market where it is impossible or very difficult for mutuals to engage in selective underwriting, commercial insurance companies applying selective underwriting could easily be accused of 'cherry-picking'. By sticking to social security-type mechanisms, insurance companies err on the safe side. However, insurers' reluctance to apply private insurance logic (such as selective underwriting) and reliance on other methods (such as setting upper limits on coverage) lead to the development of suboptimal CDI products. Moral hazard is an important problem due to the very nature of dental care. Choices among different treatment options are strongly influenced by individual consumer preferences, where aesthetic aspects often play a role. Dentists also have their preferences, which can be influenced by the consumer's and insurer's 'willingness to pay'. Dental insurance can thus provide fertile ground for both consumer- and provider-induced moral hazard. Therefore, in an optimally designed scheme, insurers ought to fully invest in countermeasures. However, classic private insurance measures such as deductibles and co-insurance are not or are not fully implemented due to public policy concerns. Rather, insurers prefer to use other measures such as offering restricted coverage, setting upper limits on coverage, and not applying a cap on out-of-pocket expenditure. However, this contributes to the development of suboptimal CDI products. The degree of randomness of losses varies between total randomness and absolute predictability. Pre-existing conditions come close to being absolutely predictable. In Belgium, France, and the Netherlands, CDI covers pre-existing conditions. Consequently, adverse selection is inadequately counteracted and a vicious circle arises whereby the insurer needs to repeatedly increase premiums to be able to continue coverage for the high risks that have subscribed the insurance policy. This leads to the development of suboptimal CDI products \[[@CR5]\]. By comparison, in Germany, CDI is effectively limited to future, unforeseen events. It may not be a coincidence that CDI in Germany generally provides unlimited coverage, in contrast to the situation in Belgium, France, and the Netherlands. The 'maximum possible loss' is also a potential explanation for the sub-optimality of CDI. Certain dental treatments, i.e., prosthetic treatments such as the replacement of multiple teeth, constitute a risk with a relatively large loss amount (more than €10,000) and a low loss frequency. Such risks can only be made insurable if the insurer is given the opportunity to build up long-term loss reserves from its premium income. However, CDI contracts can be cancelled by the insured every year. Uncertainty about the duration of the contract together with moral hazard and adverse selection may lead insurers to limit coverage, resulting in suboptimal dental insurance. Behavioral economics {#Sec7} -------------------- Van Winssen et al. \[[@CR6]\] explored potential explanations of why individuals choose suboptimal complementary health insurance. Based on key insights from behavioral economics, they discuss several factors that can have an impact on the high uptake of suboptimal insurance by consumers. For CDI, the following factors are relevant. Factors such as liquidity constraints and debt aversion may help to explain why people buy dental insurance products that provide only limited coverage. Liquidity constraints imply that individuals do not have the means to free up (substantial) funds at a given point in time. Debt aversion stems from mental accounting theory \[[@CR7]\] and is illustrated by individuals' preference to prepay for consumption and to get paid for work after completion. Ignorance and social comparison may also affect individuals' willingness to purchase suboptimal insurance. People often do not know exactly what they are insuring themselves against by taking out complementary dental insurance (see, e.g., \[[@CR8]\]) and they often do not know the costs of dental care that is (not) covered by their insurance. They often rely on what their peers decide \[[@CR9]\]. Strategies for optimizing complementary dental insurance {#Sec8} ======================================================== In many countries, MBI does not cover certain types of dental care such as prosthetic treatments (e.g., crowns, implants, and bridges) or provides only limited coverage (see, e.g., Table [3](#Tab3){ref-type="table"}). With 70% of total expenditure on dental care being privately financed in Europe, CDI can play an essential role in the affordability and accessibility of dental care. Therefore, it is important for CDI products to respond as closely as possible to the features of optimal insurance design. However, currently, many CDI products on the market are suboptimal. The gap with optimal insurance design can be explained by both supply-side aspects and demand-side aspects. From these potential explanations, the following strategies to optimize CDI can be drawn. First, public policy would like voluntary CDI products to provide both optimal insurance coverage and equal access to insurance. However, this is not possible because optimal insurance requires selective underwriting and risk rating (to counteract adverse selection to protect existing clients against free riders who abuse the insurance system), which is inconsistent with the principle of equal access. Therefore, policymakers should carefully decide which types of dental care are essential and ought to be covered by MBI. Dental care that is considered non-essential by policymakers and that is therefore not covered by MBI should be subject to private insurance logic. If, because of budgetary constraints, essential dental care cannot be covered by MBI, subsidization of private insurance for persons with low incomes might be an alternative to full public provision. Second, moral hazard could be counteracted by the systematic use of deductibles and co-insurance. Standard lists of usual market prices could be compiled (as, e.g., in the Netherlands and France) and provider networks adhering to a price list could be created. Insurers should not shy away from legal action in case of excessive amounts being claimed (i.e., excessive extra billing). Third, selective underwriting and risk rating could be used to counteract adverse selection and to protect existing clients against free riders who abuse the insurance system. Providing insurance for pre-existing conditions is incompatible with the insurance principle that only future, unforeseen risks can be covered: a burning house cannot be insured. Fourth, applying waiting times for expensive treatments such as prosthetics and providing only limited coverage during the initial years of the contract constitute alternatives to a general limitation of coverage. For instance, in Germany, limited coverage typically applies during the first 4 years of the insurance contract. Fifth, behavioral economics aspects such as liquidity constraints and debt aversion could be dealt with by offering a combination of optimal dental insurance in combination with a health (dental) savings account. The dental savings account could be used to finance trivial costs. In this way, CDI could be optimized and would not be tainted by attempts to also cover trivial risks. Ignorance and social comparison can be taken care of by improving the transparency of CDI products. Consumer organizations can play an important role in clarifying the market offer for the consumer. The authors wish to thank Richard Burton and Seraf Van Den Bosch for their corrections and suggestions.
{ "pile_set_name": "PubMed Central" }
Turbidimetric-kinetic assay of endotoxin in rumen fluid or serum of cattle fed rations containing various levels of rolled barley. A new, automated turbidimetric-kinetic (ATK) assay was used to quantitate bacterial endotoxin in rumen fluid or in serum of Holstein steers. The ATK method used Limulus amebocyte lysate (LAL) reagent with added beta-glucan (LAL-ES) which improved specific sensitivity to endotoxin. Design of the feeding trial permitted comparison of endotoxin levels found during consumption of a basal ration with those higher levels detected at various times following the introduction of increasing percentages of rolled barley to that basal ration. Both serum and ruminal endotoxin levels were significantly higher in steers on the higher concentrate rations. Peak endotoxin levels were detected 20 days following the change to the highest concentrate ration which contained 60% barley. Endotoxin levels from both sources subsequently decreased. Ruminal endotoxin stabilized at about 10 times the level, and serum endotoxin stabilized at 2 to 4 times the level, of that previously found during feeding of the basal ration. Test protocol included sample dilution and heating in order to avoid the effects of endotoxin inhibitors. Recovery rates for added endotoxin to either serum or rumen fluid supernates ranged from 120 to 136%. Coefficient of variation for endotoxin concentration in serum was lower than 10%, and in rumen fluid only slightly higher. There was significant correlation between ruminal concentration as measured by the ATK method and an alternative chromogenic substrate assay procedure. Changes in endotoxin level in experimental steers were those predictable from experience with naturally occurring incidents of grain engorgement. The ATK assay appears to be an accurate and rather simple technique which will prove useful for experimental and clinical studies in the future.
{ "pile_set_name": "PubMed Abstracts" }
Battle of Coronel The Battle of Coronel was a First World War Imperial German Naval victory over the Royal Navy on 1 November 1914, off the coast of central Chile near the city of Coronel. The East Asia Squadron (Ostasiengeschwader or Kreuzergeschwader) of the Kaiserliche Marine (Imperial German Navy) led by Vice-Admiral Graf Maximilian von Spee met and defeated a British squadron commanded by Rear-Admiral Sir Christopher Cradock. The engagement probably took place as a result of misunderstandings. Neither admiral expected to meet the other in full force. Once the two met, Cradock understood his orders were to fight to the end, despite the odds being heavily against him. Although Spee had an easy victory, destroying two enemy armoured cruisers for just three men injured, the engagement also cost him almost half his supply of ammunition, which was irreplaceable. Shock at the British losses led the Admiralty to send more ships, including two modern battlecruisers, which in turn destroyed Spee and the majority of his squadron on 8 December at the Battle of the Falkland Islands. Background At the outbreak of war the Royal Navy and the Royal Australian Navy, with assistance from New Zealand and Japanese naval and land forces in the Far East, had captured the German colonies of Kaiser-Wilhelmsland, Yap, Nauru and Samoa early in the war, instead of searching for the German East Asia Squadron commanded by Vice-Admiral Maximilian von Spee, which had abandoned its base at the German concession at Tsingtao in the expectation of war breaking out with Japan. The East Asiatic Squadron rendezvoused at Pagan Island in the Marianas in early August 1914. Eventually, recognising the German squadron's potential for disrupting trade in the Pacific, the British Admiralty decided to destroy the squadron and searched the western Pacific Ocean after the East Asia Squadron had conducted the Bombardment of Papeete (22 September 1914), where a French steamer reported its presence. On 4 October 1914, the British learned from an intercepted radio message that Spee planned to attack shipping on the trade routes along the west coast of South America. Having correctly guessed the intention of the German commander, Rear-Admiral Sir Christopher Cradock patrolled the area with a Squadron consisting of the armoured cruisers (flagship) and , the modern light cruiser , and the armed merchantman . The Admiralty had planned to reinforce the squadron by sending the newer and more powerful armoured cruiser from the Mediterranean but temporarily diverted this ship to patrol the western Atlantic. Defence reached Montevideo two days after the battle and instead, Cradock received the pre-dreadnought battleship . The change of plan meant that the British squadron comprised obsolete or lightly armed vessels, crewed by inexperienced naval reservists. Monmouth and Good Hope had a large number of 6-inch guns but only Good Hope was armed with two 9.2-inch guns mounted in single turrets. Spee had a superior force of five modern vessels (the armoured cruisers and and the light cruisers , and ), led by officers hand-picked by Grand Admiral Alfred von Tirpitz. Scharnhorst and Gneisenau carried eight 8.2-inch guns each, which gave them an overwhelming advantage in range and firepower; the crews of both ships had earned accolades for their gunnery before the war. The Admiralty ordered Cradock to "be prepared to meet them in company", with no effort being made to clarify what action he was expected to take should he find Spee. On receiving his orders, Cradock asked the Admiralty for permission to split his fleet into two forces, each able to face Spee independently. The two groups would operate on the east and west coasts of South America to counter the possibility of Spee slipping past Cradock into the Atlantic Ocean. The Admiralty agreed and established the east coast squadron under Rear-Admiral Archibald Stoddart, consisting of three cruisers and two armed merchantmen. The remaining vessels formed the west coast squadron, which was reinforced by Canopus on 18 October. Reprieved from scrapping by the outbreak of war and badly in need of overhaul, Canopus was claimed to have a top speed of only , about two-thirds her design speed and just over half that of the remainder of the squadron. (After the fleet sailed, it was found that the ship could make and that the senior engineer was mentally ill.) The Admiralty agreed that with Canopus the fleet would be too slow to force an engagement with the German cruisers and that without Canopus the west coast squadron stood no chance. Cradock sailed from the Falklands on 20 October, still under the impression that Defence would soon arrive and with Admiralty orders to attack German merchant ships and to seek out the East Asiatic Squadron. As the British squadron rounded Cape Horn, wireless transmissions from Leipzig increased in power and it seemed that the British would catch the ship while isolated, but Spee had made rendezvous with Leipzig on 14 October and had enforced wireless silence on the other ships. Lines of communication On 30 October, before the battle but due to communications delays too late to have any effect, Admiral Jackie Fisher was re-appointed First Sea Lord, replacing Prince Louis of Battenberg, who, along with Churchill, had been preoccupied with fighting to keep his position as First Sea Lord in the face of widespread concern over the senior British Admiral being of German descent. Battenberg was a proven and reliable admiral but was replaced to appease public opinion. The crisis drew the attention of the most senior members of the Admiralty away from the events in South America: Churchill later claimed that if he had not been distracted, he would have questioned the intentions of his admiral at sea more deeply. A signal from Cradock was received by Churchill on 27 October, advising the Admiralty of his intention to leave Canopus behind because of her slow speed and, as previously instructed, to take his remaining ships in search of Spee. He re-stated that he was still expecting reinforcements in the form of Defence, which he had previously been told was coming and that he had given orders for her to follow him as soon as possible. Although Defence had once been sent to reinforce Cradock, it had then been recalled part way, returned to the Mediterranean and then been sent again to form part of a new squadron patrolling the eastern coast of South America. A misunderstanding had arisen between Cradock and the Admiralty over how ships were to be assigned and used. Cradock believed he was expected to advance against Spee with those forces he had, whereas the Admiralty expected him to exercise caution, using Canopus for defence and merely to scout for the enemy or take advantage of any situation where he might come across part of the enemy force. Churchill replied to the signal, telling Cradock that Defence was to remain on the east coast and that Cradock was considered to have sufficient forces for his task, making no comment about his plan to abandon Canopus. Churchill had passed on the message to the Admiralty staff, saying he did not properly understand what Cradock intended. Cradock probably received Churchill's reply on 1 November with the messages collected by Glasgow at Coronel, giving him time to read it before the battle. Thus, Cradock would have taken the message as final confirmation that he was doing what was expected. Departing from Stanley he had left behind a letter to be forwarded to Admiral of the Fleet Sir Hedworth Meux in the event of his death. In this, he commented that he did not intend to suffer the fate of Rear Admiral Ernest Troubridge, a friend of Cradock, who at the time was awaiting court-martial for failing to engage the enemy. The governor of the Falklands reported that Cradock had not expected to survive, as did the governor's aide. Luce reported that "Cradock was constitutionally incapable of refusing or even postponing action if there was the smallest chance of success". On 3 November, Fisher in London received news from Valparaiso that Spee had been sighted. He urgently gave orders for Defence to join Cradock and stressed the need to keep Canopus together with the other ships. On 4 November, German reports of the battle started to reach London. Prelude British preparations On 22 October, Cradock cabled the Admiralty that he was going to round Cape Horn and was leaving Canopus behind to escort his colliers. Admiral John Fisher replaced Battenberg as First Sea Lord on 27 October, and the following day Fisher ordered Cradock not to engage Spee without Canopus. He then ordered HMS Defence to reinforce Cradock. The previous week Cradock had sent Glasgow to Coronel to pick up any messages the Admiralty might have sent. Spee, having learned of the presence of Glasgow off Coronel, sailed south from Valparaíso with all five warships with the intention of destroying her. Glasgow intercepted radio traffic from one of the German cruisers and informed Cradock, who turned his fleet north to intercept the cruiser. Given the German superiority in speed, firepower, efficiency and numbers, why Cradock chose to engage puzzles historians. At the time Rear Admiral Ernest Troubridge, a friend of Cradock, was awaiting court-martial for failing to engage the enemy, and he had been told by the Admiralty that his force was "sufficient". The accepted view among Cradock's colleagues was that he was "constitutionally incapable of refusing action". On 31 October, he ordered his squadron to adopt an attacking formation. Both sides are thought to have expected to encounter a single ship until they sighted each other at 16:40 on 1 November. Battle On 31 October, Glasgow entered Coronel harbour to collect messages and news from the British consul. Also in harbour was a supply ship—Göttingen—working for Spee, which immediately radioed with the news of the British ship entering harbour. Glasgow was listening to radio traffic, which suggested that German warships were close. Matters were confused because the German ships had been instructed to all use the same call sign, that of Leipzig. Spee decided to move his ships to Coronel to trap Glasgow while Admiral Cradock hurried north to catch Leipzig. Neither side realised the other's main force was nearby. At 09:15 on 1 November, Glasgow left port to meet Cradock at noon, west of Coronel. Seas were rough so that it was impossible to send a boat between the ships to deliver the messages, which had to be transferred on a line floated in the sea. At 13:5, the ships formed into a line abreast formation apart, with Glasgow at the eastern end, and started to steam north at searching for Leipzig. At 16:17 Leipzig, accompanied by the other German ships, spotted smoke from the line of British ships. Spee ordered full speed so that Scharnhorst, Gneisenau and Leipzig were approaching the British at , with the slower light cruisers Dresden and Nürnberg some way behind. At 16:20, Glasgow and Otranto saw smoke to the north and then three ships at a range of . The British reversed direction, so that both fleets were moving south, and a chase began which lasted 90 minutes. Cradock was faced with a choice; he could either take his three cruisers capable of , abandon Otranto and run from the Germans, or stay and fight with Otranto, which could only manage . The German ships slowed at a range of to reorganise themselves for best positions, and to await best visibility, when the British to their west would be outlined against the setting sun. At 17:10, Cradock decided he must fight, and drew his ships closer together. He changed course to south-east and attempted to close upon the German ships while the sun remained high. Spee declined to engage and turned his faster ships away, maintaining the distance between the forces which sailed roughly parallel at a distance of . At 18:18, Cradock again attempted to close, steering directly towards the enemy, which once again turned away to a greater range of . At 18:50, the sun set; Spee closed to and commenced firing. The German ships had sixteen guns of comparable range to the two guns on Good Hope. One of these was hit within five minutes of the engagement's starting. Of the remaining guns on the British ships, most were in casemates along the sides of the ships, which continually flooded if the gun doors were opened to fire in heavy seas. The merchant cruiser Otranto—having only guns and being a much larger target than the other ships—retired west at full speed. Since the British guns had insufficient range to match the German guns, Cradock attempted to close on the German ships. By 19:30, he had reached but as he closed, the German fire became correspondingly more accurate. Good Hope and Monmouth caught fire, presenting easy targets to the German gunners now that darkness had fallen, whereas the German ships had disappeared into the dark. Monmouth was first to be silenced. Good Hope continued firing, continuing to close on the German ships and receiving more and more fire. By 19:50, she had also ceased firing; subsequently her forward section exploded, then she broke apart and sank, with no-one witness to the sinking. Scharnhorst switched her fire to Monmouth, while Gneisenau joined Leipzig and Dresden which had been engaging Glasgow. The German light cruisers had only guns, which had left Glasgow almost unscathed, but these were now joined by the guns of Gneisenau. John Luce, captain of Glasgow, determined that nothing would be gained by staying and attempting to fight. It was noticed that each time he fired, the flash of his guns was used by the Germans to aim a new salvo, so he also ceased firing. One compartment of the ship was flooded but she could still manage . He returned first to Monmouth, which was now dark but still afloat. Nothing was to be done for the ship, which was sinking slowly but would attempt to beach on the Chilean coast. Glasgow turned south and departed. There was some confusion amongst the German ships as to the fate of the two armoured cruisers, which had disappeared into the dark once they ceased firing, and a hunt began. Leipzig saw something burning, but on approaching found only wreckage. Nürnberg—slower than the other German ships—arrived late at the battle and sighted Monmouth, listing and badly damaged but still moving. After pointedly directing his searchlights at the ship's ensign, an invitation to surrender—which was declined—he opened fire, finally sinking the ship. Without firm information, Spee decided that Good Hope had escaped and called off the search at 22:15. Mindful of the reports that a British battleship was around somewhere, he turned north. With no survivors from either Good Hope or Monmouth, 1,600 British officers and men were dead, including Admiral Cradock. Glasgow and Otranto both escaped (the former suffering five hits and five wounded men). Just two shells had struck Scharnhorst, neither of which exploded: one 6-inch shell hit above the armour belt and penetrated to a storeroom where, in Spee's words, "the creature just lay there as a kind of greeting." Another struck a funnel. In return, Scharnhorst had managed at least 35 hits on Good Hope, but at the expense of 422 shells, leaving her with 350. Four shells had struck Gneisenau, one of which nearly flooded the officers' wardroom. A shell from Glasgow struck her aft turret and temporarily knocked it out. Three of Gneisenaus men were wounded; she expended 244 of her shells and had 528 left. Aftermath This was Britain's first naval defeat since the Battle of Lake Champlain in the War of 1812 and the first of a British naval squadron since the Battle of Grand Port in 1810. Once news of the defeat reached the Admiralty, a new naval force was assembled under Vice-Admiral Doveton Sturdee, including the battlecruisers and her sister-ship . This found and destroyed Spee's force at the Battle of the Falkland Islands. Glasgow, having escaped the battle, steamed south for three days at , passing through the Straits of Magellan. Canopus—warned by Glasgows messages—turned about and headed back at the best speed she could manage, . On 6 November, the two ships met and proceeded slowly towards the Falklands. Twice during the voyage Canopus had to report that she was not under control. After coaling, both ships were ordered north but again Canopus broke down. She was finally ordered to be beached in the inner part of Stanley Harbour, where she could serve as a defensive battery. Otranto steamed out into the Pacific Ocean before turning south and rounding Cape Horn. On 4 November the Admiralty issued orders for the surviving ships to go to the Abrolhos Rocks, where a new force was being assembled. Rear-Admiral Archibald Stoddart, with the armoured cruisers and , were to meet them there and await the arrival of Defence. Sturdee was ordered to travel with the battlecruisers and —then attached to the Grand Fleet in the North Sea—to command a new squadron with clear superiority over Spee. Despite his victory Spee was pessimistic about his own chances of survival and dismissive with regard to the harm done to the British navy The official explanation of the defeat as presented to the House of Commons by Winston Churchill was: "feeling he could not bring the enemy immediately to action as long as he kept with Canopus, he decided to attack them with his fast ships alone, in the belief that even if he himself were destroyed... he would inflict damage on them which ...would lead to their certain subsequent destruction." On 3 November Scharnhorst, Gneisenau and Nürnberg entered Valparaiso harbour to a welcome by the German population. Spee refused to join in the celebrations; when presented with a bouquet of flowers, he refused them, commenting that "these will do nicely for my grave". He was to die with most of the men on his ships on 8 December 1914, at the Battle of the Falkland Islands. Commemoration The Coronel Memorial Library at Royal Roads Military College, now Royal Roads University in Victoria, British Columbia, Canada, was named in honour of the four Canadian midshipmen who perished in HMS Good Hope at the Battle of Coronel. In 1989 a memorial to those who perished in the battle was erected in the 21st May Square at Coronel, Chile. Along with two plaques depicting HMS Good Hope and HMS Monmouth, it has a central dedication plaque (in Spanish) which reads Footnotes References Further reading External links Andreas Leipold: Coronel, Battle of, in: 1914-1918-online. International Encyclopedia of the First World War. Battle of Coronel Battles of Coronel and the Falklands – a Pictorial Look Nafziger, Order of Battle Category:Naval battles of the Asian and Pacific Theatre (World War I) Category:Naval battles of World War I involving Germany Category:Naval battles of World War I involving the United Kingdom Category:Maritime incidents in Chile Category:1914 in Chile Category:Conflicts in 1914 Battle of Coronel Category:November 1914 events
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Bruno Mars is calling on a few friends to join him on the road. The pop superstar announced on Tuesday (Aug. 14) that Ciara, Boyz II Men, Ella Mai and Charlie Wilson have been added to his “24K Magic World Tour” finale. The news comes a few weeks after Cardi B, the original additional act on the tour, pulled out to take time to recovery after her pregnancy. While the new additions won’t perform together on the same night, the four will appear on various dates throughout the North American tour which kicks off on Sept. 7 in Denver, CO.
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Havana, Cuba (CNN) One bitter holdover of the Cold War slipped into the history books at 12:01 a.m. Monday, when the United States and Cuba re-established diplomatic relations. For the first time since severing ties in 1961, they reopened embassies in each other's capitals. Cuban Foreign Minister Bruno Rodriguez Parrilla traveled to the Cuban Embassy in Washington to raise his country's flag, an event that Cuban government officials said would be broadcast live on the island's state-run TV. A Cuban delegation of diplomats, artists and veterans of the revolution commemorated the breakthrough with about 500 guests and more than likely down a few celebratory mojitos and shots of Havana Club rum. U.S. diplomats in Havana have readied everything from new business cards to the embassy sign. But the festivities and flag-raising will have to wait for Secretary of State John Kerry's visit -- the highest-level trip by a U.S. official to Cuba since the 1959 revolution -- for the embassy reopening ceremony in August. Starting Monday, U.S. officials said, the Cuban government will pull back some of the tight cordon of security that had surrounded America's diplomatic mission in Havana and no longer record the names of Cubans entering the building. The Cuban and American heads of their respective Interest Sections will became charges d'affaires until ambassadors are named. Plenty of longtime enmity to overcome "A new stage will begin, long and complex, on the road toward normalization," Cuban President Raul Castro said in a televised address last week to the Cuban people. "Which will require the will to find solutions to the problems that have accumulated over more than five decades and hurt ties between our nations and peoples." If there were ever two countries in need of a "new stage" of relations, they are Cuba and the United States. Cuban Embassy sign Already frayed ties between Washington and Havana snapped in 1961 when Cuban leader Fidel Castro threatened to expel American diplomats for meddling in Cuban affairs. The United States had blasted the Cuban government's seizure of American property and the summary executions of officials from the Fulgencio Batista regime that Castro had overthrown. "There is a limit to what the United States in self-respect can endure. That limit has now been reached," President Dwight D. Eisenhower said, announcing the rupture. Swiss diplomats took over the maintenance of the seaside former U.S. Embassy and the sprawling ambassador's residence in Havana. The failed U.S.-backed invasion at the Bay of Pigs, Fidel Castro's declaration that his revolution was socialist, repeated CIA plots to assassinate Castro, and the Cuban Missile crisis further poisoned affairs for the decades that followed. Photos: The Stars and Stripes in Cuba Photos: The Stars and Stripes in Cuba Women wearing pants designed with the colors of the U.S. flag walk through Old Havana in Cuba in January. Many Cubans say displaying U.S. flags makes them no less patriotic about their own country, according to Patrick Oppmann , CNN's correspondent in Cuba. They have relatives in the States and a positive opinion of their neighbor to the north despite the antagonism between the U.S. and Cuban governments. Hide Caption 1 of 12 Photos: The Stars and Stripes in Cuba A man looks at a magazine stand in Havana in January. Hide Caption 2 of 12 Photos: The Stars and Stripes in Cuba A handkerchief in the colors of the American flag hangs on a clothesline in Havana in February. Hide Caption 3 of 12 Photos: The Stars and Stripes in Cuba A woman has her nails painted in the likeness of the Cuban and U.S. flags inside her Havana home in December. Hide Caption 4 of 12 Photos: The Stars and Stripes in Cuba The American flag is displayed on a Havana cobbler's sewing machine in January. Hide Caption 5 of 12 Photos: The Stars and Stripes in Cuba An American flag hangs next to a Cuban flag in an Havana barbershop in February. Hide Caption 6 of 12 Photos: The Stars and Stripes in Cuba American flags adorn a pedicab in Havana in January. Hide Caption 7 of 12 Photos: The Stars and Stripes in Cuba A woman wearing an American flag bandana gives her son some ice cream in Havana in January. Hide Caption 8 of 12 Photos: The Stars and Stripes in Cuba A car passes a man in Havana wearing a cap displaying the U.S. flag in February. Hide Caption 9 of 12 Photos: The Stars and Stripes in Cuba A man wearing an American flag sweatshirt walks through a street in Havana in February. Hide Caption 10 of 12 Photos: The Stars and Stripes in Cuba A man with the American flag on his sleeve stands with a woman in Havana in January. Hide Caption 11 of 12 Photos: The Stars and Stripes in Cuba Cuban and U.S. flags decorate the dashboard of a car in Havana. Hide Caption 12 of 12 But in 1977, during a brief period of improved relations in the Carter administration, Cuba and the United States opened Interests Sections in their former embassies. A step below embassies, Interests Sections allowed the Cold War foes to have diplomatic dealings without officially restoring relations. Keeping a diplomatic low profile in Cuba Diplomats returning to the old U.S. Embassy in Havana found years of dust accumulated on the furniture and calendars from 1961 still on the walls. Since the United States couldn't fly the American flag or name an ambassador to Havana, there were no obvious signs of a large U.S. diplomatic presence in Communist-run Cuba. "Most Americans who visit Cuba seem to think there's no relationship, there's just a tiny room in the Swiss Embassy. And every day they are driving past the old embassy, but they don't know there's an embassy because there's no flag," said Vicki Huddleston, who was chief of the Interests Section from 1999 to 2002. With 51 Americans and 300 Cuban employees, the U.S. Interests Section is one of the largest diplomatic missions of any country in Cuba. But instead of improving relations with Cuba, the Interests Section often served as a lightning rod for confrontation. The Cuban government plastered propaganda around the building, including one iconic sign that showed a fatigue-clad revolutionary telling a hissing caricature of Uncle Sam, "Mister imperialists, we are not the least bit afraid of you!" Fidel Castro called the section "a nest of spies" and led frequent marches with hundreds of thousands of supporters in tow to protest U.S. policies. Tarantulas would show up in the oddest places Cuban intelligence kept a close eye on American diplomats' comings and goings. "They had 3,000 to 4000 people that were focused on our personnel, trying to recruit them or harass us," said James Cason, the chief of the Interests Section from 2002 to 2005. "They would break into your house and do things to show they had control of your existence. In my days, if they knew you didn't like spiders, you would find a tarantula wandering around your room." Cuban diplomats serving in the United States complained of similar harassment at the hands of American minders. Cuban flags all but block out the U.S. diplomatic mission in Havana during frostier diplomatic times. Sometimes the intimidation backfired, as when Huddleston was informed that her Afghan hound, Havana, could no longer take part in local dog shows. "You have been thrown out of the dog club because of your country's policies and your actions," Huddleston said the letter of expulsion read. But negative publicity over the incident led Cuban officials to declare it all had been a mistake, since the dog really belonged to Huddleston's husband. "The Cubans were really embarrassed," Huddleston said. "Fidel said he would give my husband's dog a pardon. " Sometimes it was the United States that sparked diplomatic incidents, such as in 2006 when diplomats installed an electronic ticker across the top floor of the Interests Section to display information the Cuban government didn't want reported. "We decided we would talk over the heads of the regime by putting the moving billboard in the top floor of our windows," Cason said. "And one day, to the surprise of the regime, we started off with, 'People of Cuba, how come we can go to your hotels and you can't?'" The Cuban government responded by erecting a "forest" of 138 flag poles to block out the offending American messages. Eventually both the ticker and the flags came down. 'We have a formal relationship' Despite the clashes that often grabbed headlines, in recent years the United States and Cuba have quietly increased cooperation on combating drug smuggling, migrant interdiction and protecting the environment. Working together on areas of mutual interest is only likely to increase with the restoration of diplomatic relations, said John Caulfield, chief of the Interests Section from 2011 to 2014. "As an Interests Section, we were kind of radioactive for Cubans," Caulfield said. "This is a signal to Cuba and all Cubans that even if we don't have a normal relationship, we have a formal relationship." Caulfield said during his final years in Cuba, the thawing of relations was already underway, although his time in Havana was not without its intrigues. Despite the ban on raising the American flag at the Interests Section, Caulfield said his staff presented him with a memorable and clandestine present when he finished his posting. "They gave me a flag they had snuck up in the middle of the night and gave it to me as a going-away gift, and I really appreciated the gesture," Caulfield said. Soon the United States will for the first time in 54 years again fly the American flag in Havana for everyone to see.
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Q: Handling Roo generated AspectJ files in Eclipse I have generated a sample roo project using command prompt and then imported it to the eclipse.But i found that most of the important files are in aj extension.How can i change these files into java files.I want to do this in eclipse. A: If you want the .aj files to show up in the Project Explorer: Click on the down arrow on the top right corner of the Project Explorer panel. Choose Customize View... In the Filters tab, uncheck Hide generated Spring Roo ITDs (I found this question searching for how to do this, so I wrote it here) A: First of all, you do not have to convert the .aj files to java. They are Roo generated aspects which does the magic behind Roo. You should not modify or delete Roo generated .aj files. If you want to override the behavior of them, you should "Push In" refactor the methods to the necessary java files or you can simply create methods with the same method signature in the related java file. Roo will automatically modify the .aj file and remove the overridden method from the .aj file. Remember, you need to have the Roo shell running in order for this to happen or it would happen the next time you start the Roo shell. To use the "Push In" refactoring feature, you can use AJDT for eclipse, which is often the preferred plugin for AspectJ related development in Eclipse. Cheers. A: .aj files are not Java files. They are AspectJ files. These can be removed and everyhting can be moved into Java files but you won't be able to continue using Roo to handle the project changes. There are plugins for Eclipse to handle those files from the IDE. I've mostly used the SpringSource Tool Suite which is a packaged version of Eclipse that has (among other things) the proper tools to work with Roo.
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Aphakic glaucoma after congenital cataract surgery. To describe the largest series of patients who developed aphakic glaucoma after lensectomy for congenital cataracts. A retrospective review was performed of all patients seen by a pediatric glaucoma specialist between October 1, 1970, and November 30, 2002. Patients with intraocular pressures greater than 25 mm Hg after lensectomy were studied. Patients with either conditions independently associated with glaucoma or any signs of glaucoma before lensectomy were excluded. We studied 170 eyes of 117 patients. The mean +/- SD follow-up period was 8.6 +/- 7.6 years. The most common cataract types were complete (40.8%) and nuclear (22.5%). For the lensectomies, 103 eyes underwent modern vitrectomy techniques, and 10 underwent older techniques. Lensectomies were performed in 80.6% of eyes before age 1 year. Onset of glaucoma after lensectomy was by 1 year in 37.1% of eyes, by 6 years in 75.9%, and by 33 years in 100%. Of eyes that had gonioscopy, 93.9% had open angles. Glaucoma surgery was needed in 57.1% of eyes. The median final visual acuity was 20/400. Most cases of aphakic glaucoma are of the open-angle type. Various risk factors are suggested, and the prognosis is guarded. Lifelong follow-up is needed to screen for glaucoma.
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Recognition of halides and Y-shaped oxoanions by carbonylchromium-based urea-like molecules: A theoretical analysis of hydrogen bonding modes. One of the major challenges in anion recognition is to design hosts that can be used to distinguish between anions of different shapes. Urea-based molecules are widely used in anion recognition because the pair of -NH groups acts as an electron acceptor. Although these hosts can bind to both spherical anions (halides) and Y-shaped anions (oxoanions), experimental evidence to date does not provide a clear picture of what differences in the nature of the hydrogen bonding interactions could be used to distinguish between anions of different shapes. Here, we use several computational topology analyses to study the non-covalent interactions between Cr(CO)3-based organometallic urea-like hosts and halides and Y-shaped oxoanions. Our results suggest that the F(-) and AcO(-) anions are recognized experimentally due to a combination of strong interaction and large infrared (IR) shifts upon complexation, verifying the remarkable IR-reporting ability of the Cr(CO)3 moiety and its potential applications in anion recognition. The lone pairs of the oxygen atom in Y-shaped oxoanions directly interact with the -NH groups of the hosts, while all the shell electrons of the halides participate as a group in the interaction; however, the relative contributions of electrostatic and charge-transfer interactions are quite similar for the two types of anions. This insight into the nature of the anion-host interactions can be used to provide guidance for the design of hosts that differentiate between anions.
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Women are often singled out as being difficult to work for or with, but the dynamics that cause this are based in fear, just as they are with men. The way that these situations can be made healthy is for upper management to agree that the culture of their organization must adopt the ethic of reciprocity in all of their interactions with all stakeholders, especially fellow employees. This paves the way for the creation and sustainability of psychologically safe workplaces.
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Glad we’re done with all those World Cup power ranking columns. Booo-Riiiing! Are we wrong? Sure, we were head over heads in love with that particular — what was it again? riiiiight — international ’soccer’ competition while it was happening but some two weeks removed, we couldn’t tell a corner-kick from a kick in the … Continue reading →
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Efficacy of plasma exchange and methylprednisolone pulse therapy on influenza-associated encephalopathy. Patients with a new type of influenza-associated encephalopathy with high mortality are increasing in Japan and the United States. We present three patients treated with methyprednisolone pulse treatment and plasma exchange to remove cytokines, and all three patients recovered without severe sequela. IL-6 decreased dramatically after the start of the plasma exchange and methyprednisolone. Therefore when influenza-associated encephalopathy is actually diagnosed, steroid pulse therapy should be started at an early stage, and when signs of DIC and/or MOF appear, plasma exchange is recommended to remove the cytokines and NOx.
{ "pile_set_name": "PubMed Abstracts" }
Smeagol from Lord of the Rings movie, awesom Black and Grey drawing by Kinko White from Estonia
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The intriguing reactivity of functionalized beta-amino alcohols with glyoxal: application to a new expedient enantioselective synthesis of trans-6-alkylpipecolic acids. New beta-amino alcohols possessing a vinylsilane moiety were reacted with glyoxal to produce lactones that were transformed in three steps in enantiopure pipecolic acid derivatives. The key step was a totally diastereoselective ene-iminium cyclization, whose mechanism can be viewed as a direct cyclization of the vinylsilane moiety onto the iminium ion. The reactivity of two beta-amino alcohols having an allylsilane terminator was also examined. Their difference of reactivity toward glyoxal can be ascribed to the intervention of a carbocation, which presents a behavior that differs according to the position of the trimethylsilyl group.
{ "pile_set_name": "PubMed Abstracts" }
Incompetency to stand trial. Appropriateness and outcome. Of 85 persons (38% of those found incompetent to stand trial in Los Angeles County in 1983), 92% were currently charged with felonies and 62% with crimes of violence. Eighty-seven percent had a history of serious physical violence against persons and 68% had prior felony arrests. This study indicated that in this jurisdiction, incompetency to stand trial is not being used to divert mentally ill persons, charged with minor offenses, into intermediate or long-term psychiatric hospitalization to circumvent obstacles such as restrictive commitment laws and rapid hospital discharge policies. The lack of adequate postrelease planning and follow-up for most of these chronically and severely mentally ill offenders was clear. Neither the criminal justice nor the mental health system is inclined to take responsibility for their care. Mandatory community treatment on release is recommended.
{ "pile_set_name": "PubMed Abstracts" }
Is there a job out there that gives you a six-figure income, high job satisfaction and has enough job openings to make it a real possibility? The “Glassdoor Job Score” is determined by weighing three factors equally: Earning potential (median annual base salary), overall job satisfaction rating and number of job openings. The OneFifteen addiction treatment center coming online in Dayton hit another milestone today as a topping out ceremony was held for the first residential treatment facility. However the first patients likely won't be treated until October — a delay from the original date of end of June. I listened to Leon Cooperman’s talk at an event hosted by the New York Alternative Investment Roundtable. There were a few members of the media present at the event and they decided that the most interesting part of Cooperman’s talk was his comments regarding the private equity industry. “I think it’s a scam personally” Cooperman […] Despite positive rhetoric from the top, the economy may be headed for troubled waters. For one thing, the benchmark indices have not demonstrated much conviction. Further, individual names have taken some ugly dives, scaring off investors from the usual stocks to buy.Unfortunately, the situation may not improve in the nearer term. While President Trump has always spouted the message of winning against China, the actual data suggests otherwise. According to Moody's Analytics, the trade war has cost the U.S. approximately 300,000 jobs. Based on present trends, the firm estimates that the job loss tally will reach 450,000 by year's end.Another factor that has stymied stocks to buy is the political situation. Currently, we're in one of the most divisive eras in American history. With a high-stakes election coming up next year, Trump can't afford to look weak to his core voting base. Thus, the trade war might continue for at least another year.InvestorPlace - Stock Market News, Stock Advice & Trading TipsBut in the midst of this turmoil, investors have an opportunity to go contrarian with recession-resistant services stocks to buy. Although consumers are generally incentivized to curtail spending in a downturn, some service providers are simply indelible. Others help clients save money, which is a necessity in troubled times. * 10 Stocks to Sell in Market-Cursed September So without any more delays, here are my picks for recession-resistant services stocks to buy: Alphabet (GOOG, GOOGL)Source: Castleski / Shutterstock.com At first glance, Alphabet (NASDAQ:GOOG, NASDAQ:GOOGL) doesn't appear an intuitive candidate for recession-resistant services stocks to buy. With its technology-centric business, and one that is increasingly geared toward the cloud, GOOGL stock would seem more vulnerable to volatility under a recession.However, what changes the calculus for GOOGL stock is YouTube. As we all know, recessions are generally unhelpful for discretionary retail names: people simply will shut down unnecessary spending. And in some ways, that applies to services stocks as well. However, Alphabet via YouTube provides a wealth of free information (amid all the other junk).I'll use a personal example. I'm not the most technically inclined for household maintenance work. However, with YouTube, I've been able to take care of several basic jobs, allowing me to save hundreds. In a recession, I think this example will be amplified tenfold, making GOOGL stock one of the surprisingly good services stocks to buy. AutoZone (AZO)Source: Robert Gregory Griffeth / Shutterstock.com You don't have to do deep research to understand that auto sales decline sharply in a recession. But if you want the proof, here it is: according to the Federal Reserve's economic research arm, the retail automotive sector was one of the hardest hit segments of the economy during the 2008 financial crisis and the subsequent Great Recession.That's bad news for automakers. However, it might spell at least a stable revenue channel for AutoZone (NYSE:AZO) and AZO stock.Part of the allure of buying a new car is the associated benefits. For instance, many dealerships offer complementary services like oil changes for the first few years of ownership (or lease). But in a recession, such offers won't be enough to overcome consumer fears. That plays into the hands of AZO stock and related services stocks to buy. * 7 Discount Retail Stocks to Buy for a Recession Not only does AutoZone provide an extensive array of parts, their customer service team can help direct you accordingly. Combined with the do-it-yourself information available at YouTube, AZO stock appears a compelling contrarian buy in a recession. O'Reilly Automotive (ORLY)Source: Jonathan Weiss / Shutterstock.com One of the difficult aspects about figuring out which services stocks to buy for a recession is the underlying assumption: nobody truly knows what's going to happen next. With the markets still relatively elevated, it seems a recovery is possible in the nearer term. But for those who think that, I'd still recommend looking into O'Reilly Automotive (NASDAQ:ORLY) and ORLY stock.While benchmark indices still have their foot in the bull market, the automotive sector is decidedly bearish. Earlier this summer, automotive journal Jalopnik noted that car sales have slipped to a "recession-level decline." As I mentioned earlier, this is bad news for most automakers. However, it suits ORLY stock perfectly.Aside from offering a warehouse of parts, O'Reilly also provides several free services. These include critical functions, such as battery testing and "check engine light" testing. While complementary, these offers facilitate upselling for parts and specialized services. That's a big plus for ORLY stock as investors seek out viable opportunities in a distressed environment. H&R Block (HRB)Source: Ken Wolter / Shutterstock.com Among recession-resistant services stocks to buy, H&R Block (NYSE:HRB) is probably the least intuitive play. That assessment has only been exacerbated by the recent sharp decline in HRB stock. With the drop, shares have essentially gone flat for over the last three years. Certainly, this is not a great way to make an introduction.I'll freely admit that HRB stock has substantial risks. If you have a conservative portfolio, you may want to seek other services stocks. That said, if we fall into a recession, H&R Block's core business becomes all the more valuable.Yes, you can do your taxes yourself, which saves frontline costs. However, in the long run, you're better off with credentialed accounting advice. That applies even more so with small business owners and those with complex tax situations. * 10 Battered Tech Stocks to Buy Now Indeed, in these latter categories, people can save money in the long haul. With accountants guiding you to perfectly legal deductions, clients can maximize their financials and have peace of mind. Those are all valuable attributes that underline HRB stock. Aflac (AFL)Source: Ken Wolter / Shutterstock.com Supplemental insurance provider Aflac (NYSE:AFL) hasn't enjoyed the best performance over the past few months. Since the middle of July, AFL stock is down nearly double digits. With some of the recessionary fears impacting trading behavior, the equity may unfortunately be choppy over the nearer term.But in the broader picture, I think the realities of an economic downturn may inspire people to consider Aflac's services. While traditional insurance programs may cover the basics, there are always potential gaps that might not be covered. In these situations, Aflac provides a valuable service, making AFL stock one of the more critical stocks to buy.On a more personal note, I interviewed James Wright, an aircraft mechanic who suffered debilitating osteoarthritis. Wright was out of work for 20 months while he concentrated on rehabilitation. Through his dedicated commitment, as well as assistance from employment network Allsup Employment Services, he was back on his feet.Certainly, Wright is one of the lucky ones. But his story is a reminder that our health is not guaranteed. However, companies like Aflac can provide peace of mind, which is a tremendous boost for AFL stock. Carriage Services (CSV)Source: Shutterstock This is an icky topic, but death is simply a part of life, ironically enough. While it's also not dinner table conversation, investments like Carriage Services (NYSE:CSV) benefit from a guaranteed bullish narrative: we have lots of people in the U.S. and they're all going to die. As one of the biggest funeral services providers, Carriage Services and CSV stock have lucrative growth opportunities.Furthermore, now might be a great time to consider CSV as one of your top recession-resistant stocks to buy. I say this because of demographic realities. Following World War II, the U.S. experienced a surge in population size. Called the baby boom, the demographic belonging to this group peaked in 1999 at nearly 80 million. * 7 Discount Retail Stocks to Buy for a Recession Despite many who passed, there are many more waiting to knock on St. Peter's gate. In other words, CSV stock should have ample opportunities for upside. Service Corporation International (SCI)Source: Shutterstock The same arguments for CSV can be made for other funeral services stocks such as Service Corporation International (NYSE:SCI). There are certain industries where the demand does not decrease when the economy is hurting. Unfortunately, making arrangements for deceased loved ones is one of those industries.SCI states that its brands "provide families with a full range of choices, from the simplest funeral arrangements to elegant ceremonies requiring intricate planning and unique features or events." That means that while simpler services may become more popular out of necessity in a major downturn, SCI can still provide those services. CVS Health (CVS)Source: Shutterstock Prior to its rally that started in early August, CVS Health (NYSE:CVS) was contrary to its name not looking healthy. At one point, CVS stock was down nearly 20% for the year. And part of the reason was the competition. With disruptive names like Amazon (NASDAQ:AMZN) or Walmart (NYSE:WMT) attempting to take more of the healthcare pie, CVS stock has historically absorbed serious pain.Fortunately, that appears to be changing. Since the beginning of August, CVS stock is up nearly 15%, completely altering the implications behind its chart. Against January's opening price, shares are just above break even. By itself, that's nothing to write home about. But considering where it was, investors will gladly take what they can. * 7 Recent IPO Stocks That Are Melting Down But a little more patience might be in order, especially if we hit a recession. Even in a downturn, people can't avoid everyday frustrations, such as getting sick. Thus, CVS enjoys secular demand, which is why you should consider it among relevant stocks to buy. Trupanion (TRUP)Source: Shutterstock If you still have a bad taste in your mouth about the funeral services stocks to buy, don't worry: these last two names will put a smile on your face.I'm going to start this duo of stocks to buy with Trupanion (NASDAQ:TRUP), a medical insurance provider for your pets. Specifically, Trupanion insures dogs and cats, but seeing as how these are the most popular pet species, this fits well for TRUP stock.Of course, we all know how expensive medical insurance for humans is. With insuring pets, it might seem overkill. However, our pets are often a huge part of our lives. Plus, an acute issue can cost thousands of dollars. In a recession, it might make sense to insure whatever you can, thus lifting the case for TRUP stock. IDEXX Laboratories (IDXX)Source: Shutterstock IDEXX Laboratories (NASDAQ:IDXX) specializes in medical diagnostic equipment for pets. Up until a recent decline, business has been good for IDXX stock. Even with the drop in market value, shares are up nearly 47%.And against a longer-term framework, you might want to consider adding IDXX to your list of potential stocks to buy. For one thing, Americans love their furry friends. According to the American Pet Products Association, nearly 70% of U.S. households own a pet. Moreover, millennials will spend more on their pets' healthcare than on their own health-related needs. * 10 Battered Tech Stocks to Buy Now Yes, that sounds crazy, but it also underlines the bullish narrative for IDXX stock. Plus, our four-legged family members offer us humans a number of therapeutic benefits. These factors will especially be important if we incur an economic downturn.As of this writing, Josh Enomoto did not hold a position in any of the aforementioned securities. More From InvestorPlace * 2 Toxic Pot Stocks You Should Avoid * 10 Stocks to Sell in Market-Cursed September * 7 of the Worst IPO Stocks in 2019 * 7 Best Stocks That Crushed It This Earnings Season The post 10 Recession-Resistant Services Stocks to Buy appeared first on InvestorPlace. Over the past decade, Wall Street has witnessed the meteoric rise of Amazon (NASDAQ:AMZN). With a market cap of about $910 billion, AMZN stock is now one of the largest publicly listed companies. In the U.S. as well as in many other countries, it is the dominant online retailer. In recent years, Amazon has also expanded into other growth areas such as cloud computing where it has already become a leader.Source: Jonathan Weiss / Shutterstock.com However, since early July, long-term AMZN shareholders have been somewhat concerned with the stock's price action. On July 11, Amazon stock hit an 52-week high of $2035.80. On Aug. 26, it saw a recent low of $1743.51. Currently the Amazon stock price is hovering around $1850.Now many investors are wondering if this quarter AMZN stock goes and stays over $2000, a price that has become an important resistance level.InvestorPlace - Stock Market News, Stock Advice & Trading Tips * 7 Discount Retail Stocks to Buy for a Recession Until its next earnings report on Oct. 24, I expect AMZN to stay range-bound, possibly between $1750 and $1900. In other words, Amazon stock would need to show strong Q3 financial numbers that would act as catalyst to push the stock over $2,000 again. Here is why. Amazon Stock's Unimpressive Q2 EarningsIn July, when Amazon reported earnings for its second fiscal quarter of 2019 , it missed on the bottom line as it warned profits would disappoint in Q3, too. Amazon stock's EPS in the quarter was $5.22, compared to the forecast EPS of $5.56.The retail giant beat analysts' average revenue estimate by a small amount. Its Q2 revenue came at $63.4 billion. Wall Street was looking for $62.5 billion. In Q2 2018, Amazon had posted $52.9 billion in sales.Amazon stock's revenue comes from five main segments: * Retail Products (about 65% of its revenues) * Retail Third-Party Sellers (about 12% of its revenues) * Amazon Web Services, or AWS (about 15% of its revenues) * Subscriptions such as Amazon Prime (about 5% of its revenues) * Other, such as credit card agreements and advertising (about 3% of its revenues)During the quarter, Amazon's U.S. sales increased by 17% to $35.8 billion. The group's international sales grew by 9% to $16.2 billion.Amazon stock's AWS segment is the growth driver operating at high margins. The group especially uses the cash generated from AWS to fund the growth in other segments.Wall Street noted that Subscriptions, which mainly constitute Amazon Prime members, were up 37% to $4.7 billion.Investors noted that the group's renewed investments into the company are paying off as sales increased. However, this sales growth is coming at the expense of lower profit margins.Since the release of the quarterly results, investors have decreased growth expectations for the coming months, as partly reflected by the sharp drop in the AMZN stock price. Wall Street Needs to See Revenue Growth in AMZN StockNot only has Amazon stock changed the world of e-commerce, but the company has been disrupting how consumer shop overall. Yet, these earnings results show that the revenue growth of Amazon's online store, third-party sellers, and subscriptions has been decelerating.Furthermore, AWS, or Amazon's cloud business, reported its slowest growth rate in several years. Its AWS revenue hit $8.4 billion. However, the consensus estimate was for $8.5 billion. In Q2 2018, the unit revenue had been $6.1 billion. Investors were especially concerned that the growth in AWS is not offsetting the top-line declines of other segments.Over the past few years, revenue and operating profits of AWS have grown extremely quickly. However, its mouth-watering operating margins have also attracted serious competition from other tech giants.Microsoft's (NASDAQ:MSFT) Azure, Alphabet's (NASDAQ:GOOG, NASDAQ:GOOGL) Google Cloud, and Alibaba's (NYSE:BABA) cloud operations have become important competitors.Going forward, Amazon expects its investments to increase, another factor that will negatively affect its bottom line and potentially Amazon stock in the near future. The company is expected to invest heavily in its advertising business, Prime Video, international growth, shipping, and logistics.When the company releases Q3 earnings in late October, analysts will be paying attention to the various growth metrics that Amazon reports. Management gave Q3 net sales guidance to be between $66-$70 billion. This guidance would mean a growth of between 17% and 24% compared with third-quarter 2018.To me, earnings results in the past few quarters show that AMZN stock is becoming increasingly dependent on AWS for revenue growth. Therefore, in Q3 I would be interested to see the metrics for each segment. Is It Time to Buy Amazon Stock Now?If you are wondering whether you should buy Amazon stock right now, the answer depends on your evaluation of Amazon's fundamentals and on your investing time horizon.In the coming weeks, I expect AMZN stock to trade in a range between $1,750 and $1,900. If Amazon stock stays above the $1,820 level, it is likely to test $1,900 and above soon.Year-to-date AMZN share price is up over 21%. If you already own AMZN stock, you might want to hold onto your shares. However, within the parameters of your portfolio allocation and risk/return profile, you may consider placing a stop loss about 3%-5% below the current price point, especially if you want to protect your paper profits.AMZN is a is a high beta stock at 1.55. The stock market has a beta of 1.0. Therefore Amazon stock's beta measures its volatility in relation to the market. In other words, in general, AMZN stock rises more than the market in bullish conditions and decreases more when markets are falling. Short-term traders should exercise caution if they want to participate in Amazon stock's wide daily swings.Patient investors who continue to believe in AMZN may see any price dip towards or below the $1,750 level as an opportunity to go long AMZN stock and ride out its daily volatility.Amazon stock will need to stabilize and build a base again before it can deliver a long-term, sustained rally that would take the shares over $2,000. The Bottom Line on AMZN StockWhen Amazon next reports its Q3 results in October, investors will scrutinize the company's fundamentals. If the results show that the company's growth has slowed further, investors may decide that Amazon is now a maturing company. As a result, they may think that the current valuation of Amazon stock is excessive.Nonetheless, it is important to remember that a mega-company with fundamentals as robust as Amazon's could withstand several months of uncertainty. And, eventually, AMZN's management will make decisions that will move the company forward.On Sep. 25, Amazon will be holding its next hardware event. Wall Street would be looking to see what Alexa-enabled products may be introduced in the coming months.Management also continues to invest heavily in original video content development and online streaming services. I'd also continue to observe that space for its potential effect on AMZN stock revenue.In two to three years, I expect AMZN stock investors to be rewarded handsomely. Eventually, fundamental catalysts will drive Amazon stock higher, and the stock price will rise above $2,000 again.As of this writing, the author did not hold a position in any of the aforementioned securities. More From InvestorPlace * 2 Toxic Pot Stocks You Should Avoid * 10 Big IPO Stocks From 2019 to Watch * 7 Discount Retail Stocks to Buy for a Recession * 7 Stocks to Buy Benefiting From Millennial Money The post New Highs for AMZN Stock Will Come After Growth Challenges End appeared first on InvestorPlace. One of the world's largest technology companies, iPhone maker Apple (NASDAQ:AAPL), just had its biggest day of the year. Recently, the company unveiled a suite of new products and services for the rest of this year and the next. In response to this product launch event, Apple stock has soared to fresh 2019 highs.Source: Shutterstock That must mean the new iPhone is going to sell well, right? After all, for the past decade, as go Apple's iPhone sales, so goes Apple stock. Despite the iPhone 11 Flopping, AAPL Is Moving HigherBut that's no longer the case today. Instead, most analysts, insiders, and investors think that the iPhone 11 will be a flop. That's mostly because the smartphone critically lacks 5G capability whereas many other new smartphones do have this new tech.InvestorPlace - Stock Market News, Stock Advice & Trading TipsIndeed, early responses to the iPhone 11 have been tepid. The only iPhone news I saw trending on Twitter (NYSE:TWTR) the night of the reveal is how the new phone is triggering people with trypophobia. According to Wikipedia, is an "aversion to the sight of irregular patterns or clusters of small holes, or bumps." That's not exactly a bullish read on forthcoming iPhone 11 sales. * 10 Battered Tech Stocks to Buy Now In other words, AAPL stock is soaring to 2019 highs in spite of the fact that most people think the iPhone 11 will be a bust. How is that possible?One word: services.Apple's Services business has been the talk of the town for several years now. Broadly, Apple is no longer hyper-focused on growing its ecosystem of hardware users. Instead, the company is focused on deeply engaging and monetizing that ecosystem through subscription-style software services. The launch event showed that these services are on the up and up, with Apple TV+ and Apple Arcade set to launch soon at compelling price points.And that was enough to get investors to buy AAPL stock. But will this rally continue? I think so. Here's why: Services Are on the Up and UpApple's Services business is on the up and up. That's hugely important for AAPL stock, because it is the key to big profit growth in the long run.Here are the numbers: Apple's Product business has grown revenues at a choppy 2% rate over the past three years, is down about 6% so far in 2019. It currently runs at 33% and produces shrinking gross margins.Apple's Services business, meanwhile, has grown revenues at a steady 20%-plus pace over the past three years. It's up about 15% so far in 2019, and runs at 63% and is expanding gross margins.To be sure, the Products business is far bigger today. It accounts for about 80% of overall revenues. But the Services business is clearly the big growth driver here.Fortunately, that Services business is on the up and up. By the end of 2020, Apple will have a streaming TV service (Apple TV+), a video game streaming service (Apple Arcade), a music streaming service (Apple Music), and a news subscription service (Apple News+). It will also still own the App Store and iCloud.Here's the big picture: Apple's Services business will continue to grow at a double-digit pace for a lot longer. That will push Apple's overall margin profile higher in the long run, because the Services business runs at nearly double the margins as the Products business.Thus, so long as the Services growth trajectory remains on track, Apple will reasonably project as a steady revenue and profit grower in the long run. Apple Stock Has RunwayThe big bear argument against Apple stock is that it trades at 19-times forward earnings. That is both significantly above the historically average multiple for AAPL stock, and a decade high valuation for the stock.The response to the bearish argument? This isn't the Apple stock of 2015. It's the Apple stock of 2019, with the big difference being the Services business.Come 2025, there's a reasonable chance for Apple's Services business to account for about a third of overall revenues. Thus, by that time, Apple will be two parts stable growth, low margin hardware business, and one part hyper-growth, high margin software business.That former characteristic wasn't there back in 2015. Back then, this was 100% a stable growth, low margin hardware business. As such, it makes sense that during this big Services push, Apple stock is being re-rated higher, to account for bigger growth and a more attractive and sustainable margin profile.Indeed, relative to other large capitalization software growth stocks of this ilk, Apple stock is still pretty cheap. Facebook (NASDAQ:FB), Microsoft (NASDAQ:MSFT), and Alphabet (NASDAQ:GOOG, NASDAQ:GOOGL) all trade well north of 20-times forward earnings. I'm not saying Apple stock should be as richly valued as those stocks. It shouldn't. Facebook, Microsoft, and Alphabet are all growing more quickly.But I am saying that at 19-times forward earnings, AAPL stock isn't overvalued. Instead, the valuation seems fair. A fair valuation coupled with healthy fundamentals is a combination which should keep the stock on a winning path. Bottom Line on AAPL StockI don't love Apple stock here. But I do think it can head higher. So long as the outlook in the Services business remains robust -- which it does today -- then AAPL stock should benefit from a dual tailwind of upward estimates revisions and multiple expansion.As of this writing, Luke Lango was long FB and GOOG. More From InvestorPlace * 2 Toxic Pot Stocks You Should Avoid * 10 Battered Tech Stocks to Buy Now * 7 Strong-Buy Stocks Hedge Funds Are Buying Now * The 7 Best Penny Stocks to Buy The post Apple Stock Is Supported by Robust Services Growth appeared first on InvestorPlace. Is now the time to invest in Nvidia (NASDAQ:NVDA)? Nvidia stock has been on a bit of a run this month, up 12% since September 3. NVDA has gained an impressive 38% so far in 2019 -- yet remains far from the $281 highs it hit last October.Source: Hairem / Shutterstock.com The majority of analysts have it as a buy. However, despite their bullish attitude, at its current $184 level, there is little upside to buying now, when those same analysts have an average 12-month price target for NVDA of $189.27.Should you buy Nvidia stock at this point? Does it have the potential to continue growing, or has NVDA pretty much run out of steam?InvestorPlace - Stock Market News, Stock Advice & Trading Tips AI Is a Future Nvidia Stock CatalystThere is much to be said about NVDA's long term potential when it comes to AI. The company has been investing heavily in this area, looking to machine learning and autonomous vehicles as future growth areas. InvestorPlace's Chris Lau has a good read on how AI and self-driving car tech could pay off for Nvidia stock in the long term. * 10 Battered Tech Stocks to Buy Now But I want to focus on gaming because that is the area that is going to hold Nvidia back over the next year. Nvidia Missed the Gaming Console Ramp-UpMicrosoft (NASDAQ:MSFT) and Sony (NYSE:SNE) are releasing next-generation Xbox and Playstation game consoles in 2020. That is going to kick off a huge upgrade cycle, but it won't benefit NVDA. Advanced Micro Devices (NASDAQ:AMD) will be powering both of those consoles.The Nintendo Switch uses custom Nvidia silicon, but with the Switch still mid-cycle in its lifespan, an all-new version isn't expected any time soon. Nvidia stock is not going to see the sort of upside from Switch sales that it did when Nintendo's console first launched.Nvidia is also left in the cold on the most prominent experiment in video game streaming. Alphabet's (NASDAQ:GOOG, NASDAQ:GOOGL) Google is launching its Stadia cloud game streaming service in November. Stadia is a double-blow against Nvidia.Subscribers will be able to play AAA PC video game titles on a wide range of devices without the need for a powerful gaming PC equipped with a graphics card. Instead, cloud data centers will do the heaving lifting, with custom AMD GPUs delivering 4K graphics at 60 fps (with 8k and 120 fps on the horizon).If Google's Stadia is a success, AMD will get orders for more of those custom GPUs. Nvidia will likely see the demand for graphics cards to power gaming PCs take a hit. Putting Together the Pieces for Nvidia StockIf you look at the two factors spiked out here, the somewhat puzzling analyst positions make sense. Why would do many analysts have NVDA rated as a Buy, yet have 12-month price target that has only around 3% upside? The next year doesn't have a lot of revenue growth potential for Nvidia. It's largely missing out on the next-generation game console cycle, it's missing out on the biggest cloud gaming initiative, and it could see its graphics card sales take a hit should cloud gaming take off.At the same time, its investment in AI and autonomous driving technology is seen as likely to pay off in a big way, but that payday is further in the future. Putting all the pieces together, it seems probable that NVDA stock is approaching a ceiling. Buying now, you are unlikely to see major gains over the next year. But if you intend to hold onto it -- with AI ramping up and autonomous cars inching closer to mainstream -- that NVDA investment will pay off in the long term. As of this writing, Brad Moon did not hold a position in any of the aforementioned securities. More From InvestorPlace * 2 Toxic Pot Stocks You Should Avoid * 10 Big IPO Stocks From 2019 to Watch * 7 Discount Retail Stocks to Buy for a Recession * 7 Stocks to Buy Benefiting From Millennial Money The post Keep Nvidia Stock If You Have It, Just Don't Jump in Now appeared first on InvestorPlace. Big tech is at a crossroads in Washington D.C. as lawmakers in the House of Representative are seeking a trove of records in an antitrust probe, according to reports in the Washington Post and Wall Street Journal. Amazon , Apple , Facebook and Alphabet are all under the microscope as leaders of both parties in the House Judiciary Committee have requested private communications from top executives and other detailed information about their individual internal operations. Investing.com -- The House Judiciary Committee has asked Facebook (NASDAQ:FB), Alphabet (NASDAQ:GOOGL), Apple (NASDAQ:AAPL) and Amazon.com (NASDAQ:AMZN) for a broad swathe of documents related to various business issues, ramping up its antitrust scrutiny of the Internet giants. Technology start-ups spent $44bn on advertising and cloud computing from Facebook, Google and Amazon last year, according to new estimates that underline the growing economic clout of venture capital-backed businesses. Research by the hedge fund Bridgewater found that spending by private tech start-ups made up about 10 per cent of the revenue of tech giants and accounted for more than 0.4 per cent of global economic activity. Wall Street's eyes next week will be focused on Washington. Federal Reserve policy makers are expected to cut interest rates by a quarter percentage point after their meeting ends on Wednesday. That'll be the second rate cut since 2008. Fed Chair Jerome Powell finds himself in a tight spot. The U.S.-China trade war and a global slowdown have begun to pinch business spending and manufacturing output, but on the other hand, American consumers continue to spend, wages are rising, and employers keep adding jobs. Also on Wednesday: grilling in store for Google, Facebook, and Twitter. Executives from the tech giants testify before a Senate panel about removing violent content from online platforms. The hearing comes as Congress grows increasingly concerned about the use of social media by people committing mass shootings and other violent acts. Over on Wall Street, investors have begun rotating away from momentum-driven growth stocks like Google's parent Alphabet and towards beaten-down value stocks. Congress is ramping up the pressure on big tech, demanding a trove of documents from Facebook, Amazon, Alphabet and Apple as part of an anti-trust probe. House lawmakers on Friday sent letters asking the four companies to turn over internal emails from CEOs Tim Cook, Jeff Bezos, Mark Zuckerberg and Larry Page - related to acquisitions. Also requested: information from the executives on market share, their competitors and documents from other investigations. SOUNDBITE (ENGLISH) LOUISIANA ATTORNEY GENERAL JEFFREY LAND, SAYING: "We are here because there is an absolutely existential threat in our virtual marketplace." The letters come days after 50 attorneys general representing U.S states and territories banned together to officially launch a probe into whether search giant Google is abusing power as a monopoly. Apple and Facebook did not immediately respond to a request for comment, while Amazon did not immediately comment. Google pointed to a blog post issued this week that said its services "create choice for consumers."
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Rattlers Get 69-55 Win Over Presbyterian in Vegas LAS VEGAS, Nev. (Nov. 24) - The Florida A&M Men's Basketball team picked up their first win of the season as they defeated Presbyterian College 69-55 in their final game of the Las Vegas Invitational, here Saturday afternoon at the Orleans Arena. FAMU (1-5) was paced by Jamie Adams as he scored a team-high 23 points and dished out five assists, followed by a Jamari Bradshaw with 12. Walter Davis led the Rattlers on the Boards with nine, while both Markee Teal and Oneyekachuwu Odi finished with five each. PC (0-6) had three players to finish in double-digit scoring as Joshua Clyburn led the Blue Hose in scoring with 14, followed by Khalid Mutakbbir with 13 and Ryan McTavish added 10 points on the night. William Truss led the Blue Hose on the boards with seven. FAMU grabbed an early 11-6 lead on a Walter Davis dunk with 15:05 to go in the first. PC countered with a 13-1 run to take a 19-12 lead on a Clyburn layup with 8:24 left in the half. The Blue Hose would extend their lead to 31-20 on a Clyburn layup with 3:57 to go in the half. FAMU would close out the half with a 13-3 run as they went into the break trailing PC 34-33, capped off by a Davis free throw with 46 seconds left in the half. The Rattlers finished the first half shooting 33.3 percent (11-of-33) from the field, while the Blue Hose shot 52.4 percent (11-of-21). A Bradshaw three-pointer tied the game at 40-40 with 15:55 to in the game. It would be two minutes before either team would score as Reggie Lewis scored with 13:49 to go in the game, giving the Rattlers a 42-40 lead, sparking a 14-1 run by FAMU as the Rattlers made the score 54-41 on an Adams three pointer with 10:05 left in the game. The Rattlers would extend their lead to 64-47 on another Bradshaw three pointer with 4:03 left in the game as FAMU held on for the 69-55 win. FAMU finished the game shooting 48.4 percent (15-of-31) from the field, while PC finished the game shooting 38.1 percent (8-of-21). The Rattlers held the rebounding edge over the Blue Hose 33-30. Online Public Information File Viewers with disabilities can get assistance accessing this station's FCC Public Inspection File by contacting the station with the information listed below. Questions or concerns relating to the accessibility of the FCC's online public file system should be directed to the FCC at 888-225-5322, 888-835-5322 (TTY), or fccinfo@fcc.gov.
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Hanging out on a street corner in Bushwick, Brooklyn is quite a bit different now than it used to be. There are still bodegas here and there, but they're mixed in with plenty of organic markets and farm-to-table, nose-to-tail brunch spots -- or, as "Saturday Night Live" would have it, the occasional "artisanal mayonnaise" shop. In a brilliant sketch about gentrification, three friends -- Keenan Thompson, Jay Pharaoh and this week's host, Kevin Hart -- hang out in their neighborhood and discuss what they've been up to of late. Recent activities include: Eating gelato on the street, painting landscapes while sipping white wine and hanging out with their "bitches" -- which, in Bushwick 2015, means running a booming dog-walking business. Advertisement: Watch the hilarious skit below:
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Kill the Drive Kill the Drive is a four-piece punk rock band, formed in Haifa, Israel in 2005. The band started as a skate punk trio and gained their first recognition releasing their third album Lady Karma on Broken English Records, in 2012. History Formation and Roadkill (2005–2008) The band was formed in the summer of 2005, in Haifa, Israel, as a skate/hardcore punk trio, with Eyal Reiner on lead vocals and bass, Yuval Segal on guitar, and Gideon Berger (younger brother of Useless ID's Ishay Berger) on drums and percussion, under the name Increase, though not long after formation, guitarist Yuval Segal decided to leave the band and was replaced with Lavy Josephson. Segal returned to the band not long after, and the band decided to stay as a four-piece with both Segal and Josephson on guitars. The band started playing live right away, playing their first live show at the Patiphone club in Tel Aviv. though their close connection to internationally known punk rock band Useless ID landed them many opening slots for Useless ID, as well as other big name Israeli bands such as Betzefer and Man Alive. In September 2005, the band opened for Australian Jewish punk rock band Yidcore and Useless ID on their co-headlining tour of Israel, at the show that took place at the Barby club in Kfar Saba. Not long after, Segal has once again left the band, and the band stayed as a trio. They then decided to record their first demo tape Short Notice, which included 7 songs and was self-released in February 2006. The band celebrated the release of the demo, opening for Useless ID and Whorecore at the City Hall club in Haifa, on February 10, 2006. On July 28, 2006, the band served once again as the opening act for Useless ID, along with ska punk band Cuban B, at the City Hall in Haifa. On December 6, 2006, the band self-released their first full-length album studio album Roadkill. The album was available only through the band and through the website Interpunk. Following the release of the album, the band served as the opening act of the 3-date Betzefer vs. Useless ID Hanuka Tour, opening for Useless ID and Betzefer, along with supporting acts The Fading and This Means You. Shows took place in Tel Aviv, Haifa and Jerusalem. In the summer of 2007, the band went on their first tour of the US, playing for two months, mainly in the West Coast. Returning from their US tour in September, the band opened for NOFX on their first Israeli tour, at the Haifa show on September 7, 2007. The band then continued playing many shows throughout Israel, mainly Tel Aviv and Haifa, though then guitarist Lavy Josephson has decided to quit, and was replaced by Gal Pearlman. On April 8, 2008, the band opened for American nintendocore band HORSE the band on their first Israeli show, in Haifa. The band was also set to open for Sick of It All on June 18, 2008, as part of their Israeli tour, though this tour was eventually cancelled due to poor ticket sales. A Postcard from Hell (2008–2010) On October 4, 2008, the band participated in the show celebrating the release of the first Israeli punk rock compilation by the label High Fiber, which included a previously unreleased song by the band, entitled "Take Me". The release of the compilation took place at the Barby club in Tel Aviv. Around that time, the band was getting ready to record their second studio album, that they have started writing back in 2007. The band started recording their second studio album, with Useless ID frontman Yotam Ben-Horin as producer. In January 2009, the band was signed by Japanese label Radtone Music, who set a release date for their second album A Postcard from Hell, in May 2009, though only in Japan. Before the release of the album, throughout February–March 2009, the band went on their first tour of the UK, when they decided to relocate to a London apartment for the time being, playing shows all around the London area, and promoting the band. A little bit after the release of the album, another major line-up change has been made, and Nadav Rotem has joined as the band's bassist, letting Reiner to focus solely on vocals, though the band then decided to add another guitar, with Reiner switching to rhythm guitar instead of bass. The Israeli release show for A Postcard from Hell took place on September 10, 2009, at the OzenBar. The band then played as an opening act for The Fading on a show that took place at the Sublime club on October 12, 2009, that saw for the first time as a four-piece, since 2006. On January 1, 2010, the band supported Man Alive on their 10-year anniversary show at the Barzilay club in Tel Aviv. Following that show, guitarist Gal Pearlman was replaced by Or Yaakov on the lead guitar position. The band continued to perform all around Israel throughout 2010, playing at the Showdown Festival on May 19, 2010, and opening for Frank Turner in Tel Aviv (June 4, 2010) and Haifa (June 6, 2010). Lady Karma and signing to Broken English Records (2011–present) In February 2011, bassist Nadav Rotem has decided to leave the band to focus on his other band Kids Insane and was replaced by Man Alive bassist Jonathan Shkedi. With Shkedi, the band flew to New York City in April 2011, to record their third studio album Lady Karma with producer John Naclerio, at Nada Recording Studio, where such bands as Polar Bear Club and The Audition have recorded. Recording took place between April 5–24, 2011. On October 30, 2011, the first song from the third album, "Apocalypse 101", was released for free streaming through SoundCloud. On November 11, 2011, the first official single from the album, "Monsters In My Bed", was released along with a music video. The album release show for Lady Karma took place on December 3, 2011, at the OzenBar in Tel Aviv. In February 2012, the band was signed by US label Broken English Records (Just Surrender, Asteria), making their third album Lady Karma available for the first time in the US, Canada and South America. The album was released on February 9, 2012, being the band's first album officially released outside of Israel and Japan. On March 6, 2012, it was announced that the band was signed by European label Fond of Life Records (This Is a Standoff, Failsafe) to release Lady Karma in Europe. On March 7, 2012, it was announced that drummer Gideon Berger will be joining Useless ID as their new drummer, following Jonathan Harpak's departure, though he will remain in both bands. On May 10, 2012, the band announced they will be shooting a music video for the second single off Lady Karma, "Apocalypse 101", over the weekend. The music video premiered on BlankTV on June 18, 2012. On December 29, 2012, the band played their final show for 2012, and last one with lead guitarist Or Yaakov, before his move to the United States, at the Wunderbar in Haifa, along with Kids Insane and Magnolia. On October 25, 2013, the band played their first show in almost a year, and their first with guitarist Roman Mishko of Chains of Past Decisions, who replaced Or Yaakov who was still out of the country. This followed the band going to a Japanese tour on November 1–4, 2013, supporting Useless ID. Band members Eyal Reiner - lead vocals (2005–present), rhythm guitar (2009–present), bass (2005–2009) Or Yaakov - lead guitar, backing vocals (2010–present) Jonathan Shkedi - bass (2011–present) Gideon Berger - drums, percussion (2005–present) Former members Nadav Rotem - bass (2009–2011) Gal Pearlman - guitar (2009–2010) Lavy Josephson - guitar, backing vocals (2005–2009) Yuval Segal - guitar (2005) Discography Studio albums Roadkill (2006) A Postcard from Hell (2009) Lady Karma (2011) EPs Short Notice (2006) References Category:Israeli punk rock groups Category:Musical groups established in 2005
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[Mild and severe organic brain disorders in childhood]. An outline of the classification of minor brain dysfunction and severe brain syndrome is followed by a short historical sketch of the development of the concept of minor brain dysfunction and a description of the clinical and diagnostic relevance of this concept. After evaluation of specific therapeutic approaches, selected empirical studies are reported to elucidate the course of the disorder. The issue concerning the existence of a behavioral syndrome that characterizes severe brain disorders is discussed. The presentation of selected research findings on psychopathological and neuropsychological sequelae of severe brain traumas provides the argument for the final discussion. The necessity of qualifying a highly specific, narrowly defined psychopathological syndrome in childhood is emphasized.
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Despite a sour year in which Berkshire Hathaway posted a loss and was forced to write down $3 billion on its investments, Warren Buffett told shareholders that he wants to make a big acquisition. There is just one problem: Prices are too high. "In the years ahead, we hope to move much of our excess liquidity into businesses that Berkshire will permanently own. The immediate prospects for that, however, are not good: Prices are sky-high for businesses possessing decent long-term prospects," Buffett wrote in the letter released Saturday morning. "That disappointing reality means that 2019 will likely see us again expanding our holdings of marketable equities," Buffett added. "We continue, nevertheless, to hope for an elephant-sized acquisition. Even at our ages of 88 and 95 – I'm the young one – that prospect is what causes my heart and Charlie's to beat faster." He also said, however, that this was "not a market call," noting he did not know how stocks will actually behave this year. Buffett said Berkshire Hathaway had $112 billion in cash at the end of 2018, despite taking a beating on its investment in beleaguered consumer giant Kraft Heinz. Investors were eager to find out what Buffett's plans were for Berkshire Hathaway's massive cash pile. In past years, Buffett has told investors he had not found anything to buy that wasn't overpriced. Meanwhile, Berkshire Hathaway has taken a massive stake in Apple over the past three years. The business giant has also added to its bank holdings and took new stakes in airlines. Buffett's annual letter comes days after Kraft Heinz, one of the company's biggest holdings, wrote down more than $15 billion on two of its most well-known brands: Oscar Mayer and Kraft. Kraft Heinz also trimmed its dividend and disclosed that the Securities and Exchange Commission is investigating its accounting practices. The news sent Kraft Heinz's stock down about 30 percent and slashed the value of Berkshire's stake in the company by more than $4 billion. It also led Barclays analyst Jay Gelb to slash his earnings estimate on Berkshire in half. The analyst also said in a note to clients that Berkshire's quarterly numbers will likely be impacted by "substantial catastrophe losses for the global insurance industry" due to the wildfires in California last year and Hurricane Michael. Click here to review past letters. To review video of Berkshire's past annual meetings and other Buffett interviews go to CNBC's Warren Buffett Archive. —CNBC's Liz Moyer contributed to this report.
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Mushabian culture The Mushabian culture (alternately, Mushabi or Mushabaean) is an archaeological culture suggested to have originated among the Iberomaurusians in North Africa, though once thought to have originated in the Levant. Archaeologists' opinions According to Ofer Bar-Yosef : "A contemporary desertic entity was labeled "Mushabian," and was considered to be, on the basis of the technotypological features of its lithics, of North African origin. The fieldwork done in recent years in northern Sinai and the Negev has shown that the forms of the Mushabian microliths (mainly curved and arched backed bladelets) and the intensive use of the microburin technique was a trait foreign to previous Levantine industries, but instead is closer to the Iberomaurusian." According to Thomas Levy: "The Mushabian is commonly considered to have originated in North Africa, largely on the basis of habitual of the microburin technique and general morphological similarities with some assemblages in Nubia(Phillips and Mintz 1977; Bar-Yosef and Vogel 1987." According to Eric Delson: "A different industry, the Mushabian, is marked by steeply arched microliths and the frequent use of the microburin technique. The Mushabian is found exclusively in the arid interior southern Levant (e.g., Sinai), suggesting it could represent an arid-land adaptation. Some researchers have noted stylistic continuities between the Mushabian and the Ibero-Maurusian of North Africa, suggesting the Mushabian may represent a migration of African groups into the southern Levant." According to Deborah Olszewski: "At the time that Henry and Garrard analyzed and published the Tor Hamar assemblage, it was commonly believed that microburin technique appeared relatively late in the Levantine Epipaleolithic sequence, perhaps being derived from microburin technique in Egypt. Since then, however, several Jordanian sites have produced evidence of microburin technique well in advance of the latter part of the Epipaleolithic sequence. These include Wadi Uwaynid 18 and Wadi Uwaynid 14 in the Azraq region of Jordan, with radiocarbon dates between 19 800 and 18 400 uncal. BP, Tor at-Tareeq in the Wadi al-Hasa area of Jordan, with radiocarbon dates between 16 900 and 15 580 uncal. BP, and Tor Sageer, also in the Wadi al-Hasa area, with radiocarbon dates between 22 590 and 20 330 BP. This new evidence clearly documents the use of the microburin technique in the inland Levant during the earliest phases of the Epipaleolithic. Thus, its presence at sites such as Wadi Madamagh and Tor Hamar cannot necessarily be used to link these sites to the Mushabian Complex, a fact also noted by Byrd". According to Nigel Goring-Morris: "Another technological shift is reflected in the approach to microlith fabrication, when backed microliths replaced finely retouched types, sometimes using the microburin technique. The introduction and systematic use of this technique in the Levant (i.e., Nebekian, Nizzanan, and later the Mushabian, Ramonian, and Natufian) are an endemic phenomenon, originating east of the Rift Valley". Early migrations The migration of farmers from the Middle East into Europe is believed to have significantly influenced the genetic profile of contemporary Europeans. The Natufian culture which existed about 12,000 years ago in the Levant, has been the subject of various archeological investigations as the Natufian culture is generally believed to be the source of the European Neolithic. The Mediterranean Sea and the Sahara Desert were formidable barriers to gene flow between Sub-Saharan Africa and Europe. But Europe was periodically accessible to Africans due to fluctuations in the size and climate of the Sahara. At the Strait of Gibraltar, Africa and Europe are separated by only 15 km of water. At the Suez, Eurasia is connected to Africa forming a single land mass. The Nile river valley, which runs from East Africa to the Mediterranean Sea served as a bidirectional corridor in the Sahara desert, that frequently connected people from Sub-Saharan Africa with the peoples of Eurasia. Mushabian-Kebaran merge According to Bar-Yosef the Natufian culture emerged from the mixing of the Geometric Kebaran (indigenous to the Levant) and the Mushabian (most likely North African). Modern analyses comparing 24 craniofacial measurements reveal a predominantly cosmopolitan population within the pre-Neolithic, Neolithic and Bronze Age Fertile Crescent, supporting the view that a diverse population of peoples occupied this region during these time periods. In particular, evidence demonstrates the presence of North European, Central European, Saharan and strong Sub-Saharan African presence within the region, especially among the Epipalaeolithic Natufians of Palestine. These studies further argue that over time the Sub-Saharan influences would have been "diluted" out of the genetic picture due to interbreeding between Neolithic migrants from the Near East and indigenous hunter-gatherers whom they came in contact with. However, a recent study showed that Natufians had no Sub-Saharan admixture. Ricaut et al. (2008) associate the Sub-Saharan influences detected in the Natufian samples with the migration of E1b1b lineages from North Africa to the Levant and then into Europe. Entering the late mesolithic Natufian culture, the E1b1b1a2 (E-V13) sub-clade has been associated with the spread of farming from the Middle East into Europe either during or just before the Neolithic transition. E1b1b1 lineages are found throughout Europe but are distributed along a South-to-North cline, with an E1b1b1a mode in the Balkans. "Recently, it has been proposed that E3b originated in sub-Saharan Africa and expanded into the Near East and northern Africa at the end of the Pleistocene. E3b lineages would have then been introduced from the Near East into southern Europe by immigrant farmers, during the Neolithic expansion".'''' Also,"a Mesolithic population carrying Group III lineages with the M35/M215 mutation expanded northwards from sub-Saharan to North Africa and the Levant. The Levantine population of farmers that dispersed into Europe during and after the Neolithic carried these African Group III M35/M215 lineages, together with a cluster of Group VI lineages characterized by M172 and M201 mutations".Loosdrecht et al. (2018) consider that the Natufians arose from a population without SSA influences either in Morocco, Libya, or the Levant."We speculate that the Natufian-related ancestral population may have been widespread across North Africa and the Near East, associated with microlithic backed bladelet technologies that started to spread out in this area by at least 25,000 yr B.P. [(10) and references therein]. However, given the absence of ancient genomic data from a similar time frame for this broader area, the epicenter of expansion, if any, for this ancestral population remains unknown. Although the oldest Iberomaurusian microlithic bladelet technologies are found earlier in the Maghreb than their equivalents in northeastern Africa (Cyrenaica) and the earliest Natufian in the Levant, the complex sub-Saharan ancestry in Taforalt makes our individuals an unlikely proxy for the ancestral population of later Natufians who do not harbor sub-Saharan ancestry. An epicenter in the Maghreb is plausible only if the sub-Saharan African admixture into Taforalt either postdated the expansion into the Levant orwas a locally confined phenomenon. Alternatively, placing the epicenter in Cyrenaica or the Levant requires an additional explanation for the observed archaeological chronology."'' Notes Although a migration of people from Africa bringing E-M78 lineages into the Levant took place c. 14,700 years ago it as yet cannot be linked with any of the Levantine cultures at the time (Hamran, Mushabian, Ramonian, Geometric Kebaran) or later (Natufian, Harifian, Khiamian) since all are known to have originated in the Levant. Since a material culture cannot be connected with the E-M78 immigrants into the Levant it is likely they were assimilated into the various Levantine cultures beginning with the Ramonian culture, which was present in the Sinai 14,700 years ago. This migration coincided with the population overflow in the Sinai and Negev that caused the Geometric Kebarans to fall back to the Mediterranean core area which in turn caused them to develop the Natufian culture as a result of the population increase in the Mediterranean park forest. References Category:Archaeological cultures of Asia Category:Stone Age Asia
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The present invention relates generally to equipment utilized and operations performed in conjunction with subterranean wells and, in embodiments described herein, more particularly provides well tools with actuators utilizing swellable materials. Many well tools are commercially available which are actuated by manipulation of a tubular string from the surface. Packers, liner hangers, jars, etc. are some examples of these. Other well tools may be actuated by intervention into a well, such as by using a wireline, slickline, coiled tubing, etc. Still other well tools may be actuated utilizing lines extending to the surface, such as electrical, hydraulic, fiber optic and other types of lines. Telemetry-controlled well tools are also available which are actuated in response to electromagnetic, acoustic, pressure pulse and other forms of telemetry. However, each of these actuation methods has its drawbacks. Manipulation of tubular strings from the surface is time-consuming and labor-intensive, and many well operations cannot be performed during manipulation of a tubing string. Intervention into a well with wireline, slickline, coiled tubing, etc., typically obstructs the wellbore, impedes flow, requires a through-bore for the intervention, requires specialized equipment and presents other difficulties. Electrical, hydraulic and fiber optic lines are relatively easily damaged and require special procedures and equipment during installation. Telemetry requires expensive sophisticated signal transmitting, receiving and processing equipment and is limited by factors such as distance, noise, etc. It will, thus, be readily appreciated that improvements are needed in the art of actuating well tools.
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About 4 results for "kamlesh vyas" Malad resident Jatin Mer, 35, has filed a First Information Report (FIR) dated July 17 at the Amboli police station against the grandson of late PD Dattani aka Dattanibappa, one of the founders of iconic food brand, Lijjat Papad. Mer alleged that ...Mid Day, 1 week ago — By | Jun 15, 2015 02:09 am Indore : The Institute of Company Secretaries of India (ICSI) is focusing on quality improvement of fellow CSs. The course structure of the ICSI is under revision and emphasis is on to improve the quality of the fallow ... From Chicago Bureau BARTLETT, Ill. More than 220 people benefited at no cost from the annual health fair, staffed by 90 volunteers, organized here by the Jain Society of Metropolitan Chicago (JSMC) May 3 and 17. Numerous diagnostic screenings ...
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Living Room Modern The beauty of modern-day interiors is that your whole house or apartment One of the easiest styles to pick up for a living room, dining area corner, a passageway or even your bedroom, is vintage. There's immense power and sophistication in paisleys (MENAFN Press) Dubai, UAE (August 3, 2015): Welcome your guests into a living room that radiates a timeless elegant appeal and evokes inviting comfort with the Calligaris Divano Lounge series, the contemporary Italian interiors brand known all over the Images » Luxury Kitchen » Kitchen Renovation Exciting Open Floor Plan Kitchen Dining living room modern Luxury Brown Decorating Ideas With Cool Lighting And Awesome Furniture And Tile Floor And Ceiling Tray Kitchen Floor Plan Ideas Luxury Dining Room Luxuriously modern bathrooms will be all marble, and in the Penthouse Suite in particular, guests will have the option of closing off a patterned glass wall to the living room to create a distinctive and private bedroom space. off the dining room and kitchen was designed for year-round living. There's a barbecue, television, fireplace and ceiling heaters. "A big part is of the reason this house is special is because of the family who wanted a modern aesthetic, places to be While track lighting works well in kitchens and living rooms, which often have auxiliary light sources This rings especially true in contemporary settings, Hill says. "Design-wise, track has a more modern or eclectic feel," he says. . Barclay also used that granite to top a custom iron and stone console table that sits against the back wall of the living room. “It’s traditional but has a modern twist to it,” Barclay said. The coffee table is made of Bastagne Walnut and forged iron. As we've looked at the transformations of a few spaces in the Heincker home, my favorite of these projects has been the family room. A large, 24-by-20 dual living/family room is wingback chairs), and very modern (chrome and glass side tables, mid Putting together a beautiful space is less mysterious than it seems. Once you know the tricks decorators depend on, the fairy dust follows. Here are the layman-level strategies you need to achieve pro-level success. Commit to a style Take a look at the There is a corner solarium off the living room. The kitchen is entered from the front hall a step-up oval Jacuzzi tub with pot lights on the floor, a modern vanity sink, pot lights and an oversized separate glass steam shower. The second and third .
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Behavioral effects of chronic WIN 55,212-2 administration during adolescence and adulthood in mice. Marijuana, a psychoactive drug that activates cannabinoid-1 (CB1) receptors in the brain, is the most prevalently abused illicit drug among American adolescents and young adults. However, the long-term consequences of adolescent exposure to cannabinoids on the brain and behavior remain poorly understood. In both humans and nonhumans, adolescence is characterized by the maturation of the endocannabinoid neurotransmitter system in the prefrontal cortex and striatum-brain regions that underlie choice and decision making and are densely packed with CB1 receptors. In the current study, the effects of chronic WIN 55,212-2 (a CB1 agonist) exposure during adolescence on reversal learning and delay discounting were compared with those of adult-onset exposure using mice. Mice were administered 3.0 mg/kg/day WIN 55,212-2 or vehicle for 21 days beginning in adolescence (postnatal days 28-49) or adulthood (postnatal days 90-111). For the reversal-learning task, there was no difference in errors or omissions to criterion following a reversal in adolescent-exposed mice but adult-exposed mice showed a delay in beginning the reversal, suggesting that adolescents, but not adults, are resilient to this drug. Adult mice given WIN 55,212-2 in adolescence displayed greater impulsivity in the form of preference for smaller-sooner reinforcers over larger-delayed ones in the delay-discounting procedure, but this was seen to a lesser extent with adult-onset exposure. These data underscore the importance of variables related to the timing and duration of exposure as well as the specific and persistent behavioral endpoints affected by chronic cannabinoid administration. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
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PHILADELPHIA – A simple test performed at the sideline of sporting events can accurately detect concussions in athletes, according to study by researchers at the University of Pennsylvania School of Medicine. Current sideline tests can leave a wide amount a brain function untested following concussion. Penn researchers showed that this simple test adds to current methods and accurately and reliably identified athletes with head trauma. The study appears online now in Neurology. The one-minute test involves the athlete reading single digit numbers displayed on index-sized cards. Any increase (worsening) in the time needed to complete the test suggests a concussion has occurred, particularly if the delay is greater than five seconds compared to the individual’s baseline test time. The test, called the King-Devick test, captures impairments of eye movement, attention, language and other symptoms of impaired brain function. It looks at saccadic and other types of eye movements that are frequently abnormal following a concussion. “This rapid screening test provides an effective way to detect early signs of concussion, which can improve outcomes and hopefully prevent repetitive concussions,” said the study’s senior author, Laura Balcer, MD, MSCE, Professor of Neurology, Ophthalmology and Epidemiology at the University of Pennsylvania School of Medicine. “If validated in future studies, this test has the potential to become a standard sideline test for athletes.” While more extensive testing can best capture post-concussion syndrome symptoms, and these tests may be influenced by other factors such as intellectual ability or depression, tests of rapid number naming such as the King-Devick test are objective and capture many aspects of function. This may help coaches and athletic trainers determine whether players should be removed from games or not. As emphasized by the study’s lead author, Kristin Galetta, MS, "Concussion is a complex type of brain injury that is not visible on the routine scans we do of the brain, yet is detectable when we measure important aspects of brain function, such as vision. The K-D test is only one test on the sidelines, though, and the diagnosis of concussion requires a combination of tests and input of medical professionals." In a study of 39 boxers and MMA fighters, post-fight time test scores were significantly higher (worse) for those who had head trauma during their matches (59.1 ± 7.4 vs 41.0 ± 6.7 seconds, p < 0.0001). Among those with head trauma, fighters who lost consciousness had even higher post-fight scores compared to those who didn’t lose consciousness (65.5 ± 2.9 vs 52.7 ± 2.9 seconds, p < 0.0001). Test times improved by more than a second on average for participants who did not have head trauma, while average times for those who suffered head trauma worsened by 11.1 seconds. Fighters who lost consciousness were 18 seconds slower on the test after their bouts. The study was funded by a grant from the National Eye Institute. A follow-up study, looking prospectively at college athletes at the University of Pennsylvania, is examining changes in athlete test scores over the course of a season, reliability of retest or tests conducted by different testers such as athletic trainers, and establish test norms and expected ranges of pre-competition scores for this age group. It will also provide large-scale results to further evaluate the effectiveness of the test to identify closed head injury and concussions accurately. The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 17 years, according to U.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $392 million awarded in the 2013 fiscal year. The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top "Honor Roll" hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; Chester County Hospital; Penn Wissahickon Hospice; and Pennsylvania Hospital -- the nation's first hospital, founded in 1751. Additional affiliated inpatient care facilities and services throughout the Philadelphia region include Chestnut Hill Hospital and Good Shepherd Penn Partners, a partnership between Good Shepherd Rehabilitation Network and Penn Medicine. Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2013, Penn Medicine provided $814 million to benefit our community.
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It's my cakeday, invest all your karma in me 182 shares
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Last night I sat in front of my computer for hours with a blank page open, trying to think about how I would finally write a presidential endorsement for The Verge. I wanted to be eloquent, sharp, and timeless — to make a poetic stand In Defense Of The Republic. But after a bit of tequila and a lot of writer’s block, I gave up, closed the tab, and went to bed. Today I saw this video today of Donald Trump getting booed on his way in and out of a voting booth in his home state. It’s better than anything I could have written. Here's a video of @realDonaldTrump getting booed on his way to vote for himself... pic.twitter.com/l0zWQrpFS9 — Harrison Greenbaum (@harrisoncomedy) November 8, 2016 In 1925, Baltimore Sun columnist H.L. Mencken surveyed the debate on evolution made famous in the Scopes trial -- a contest that set rationality and progress against dogma and fear. "On the one side was bigotry, ignorance, hatred, superstition, every sort of blackness that the human mind is capable of," Mencken wrote. "On the other side was sense." I cannot think of a more useful way to describe what we have seen in the campaign of Donald Trump. Trump’s cynical quest for power will probably end today. He will not stand in the ranks of the dictators he admires. He will be remembered as a sad, small tyrant who rode a wave of Facebook hoaxes and Twitter hate to hijack a party. And for what? To promote his golf courses, hotels, and above all, himself. He will now be the punchline of a joke we tell each other every four years, until the end of our democracy, a long time from now. Today Donald Trump’s campaign ended the same way his life in New York began: to the sound of ridicule. So long, Mr. Trump. The haters and losers are winning. Amazing how the haters & losers keep tweeting the name "F**kface Von Clownstick" like they are so original & like no one else is doing it... — Donald J. Trump (@realDonaldTrump) May 3, 2013 Trump’s success reveals weakness in our democracy
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Search form Sartre, Meet Sarkozy September is the month of La rentrée, that time of year when the French return to work or, anyway, to their jobs. And hyperkinetic President Nicolas Sarkozy has set such a blistering pace for his ministers ("Like your Energizer bunny," a weary bureaucrat tells an American reporter) that memories are fading fast of those languorous holidays on topless beaches where the French whiled away the last days of summer. But one subject for passionate debate that emerged in the heat of August still lingers: do the French as a people discuss, contemplate, cogitate—in fact, think—altogether too much? The calculated impression given by Sarkozy and his cabinet is that, yes, indeed, they do. Since long before his election in May, Sarkozy has talked about the need "to move from incantation to action." And the discussion was opened in earnest when Finance Minister Christine Lagarde fired a shot across the brow of French intellectuals in July. "It's an old national way of doing things: France is a country that thinks," said Lagarde, who as a young woman studied briefly at a prep school in the United States and later headed the major U.S.-based law firm Baker & McKenzie. "In our libraries we have enough to talk about for centuries to come. That's why I'd like to say to you: enough thinking already. Let's roll up our sleeves." The aim, of course, is to pull the French out of that supposed citadel of intellectualizing where they retreat to opine with lofty superiority about the global competitors that are passing them by. As journalist Gilles Delafon says in his recent book, called "Hello Earth? It's France …," this is a "curious country that perceives every change as an attack, every evolution as a regression, and all adaptation as surrender." Sarkozy's relentless call for aggressive efforts to energize the population and his suspicion of academic blather sounds perfectly common-sensical to American ears. There is, after all, an "old national way of doing things" in the United States that disparages "eggheads," a term used by supporters of President Dwight D. Eisenhower in the 1950s, and denounces "pointy-headed intellectuals," in the phrase made famous by the late Alabama demagogue George Wallace. "All talk and no action" is a well-known American put-down. But the context in France is profoundly different. This, remember, is the country of 17th-century philosopher René Descartes. "Cogito ergo sum," he wrote—I think, therefore I am—and that idea is as deeply ingrained in the French psyche as the pioneer spirit is in the American. "Instead of deploring this, I think we ought to congratulate ourselves," says author Pierre Assouline, who writes the widely read Le Monde blog La République des Livres. "The idea that thought and action are opposites is so puerile there's nothing to discuss." And when it comes to talking, well, "the French have made conversation one of the fine arts," says Assouline. "I suppose Madame Lagarde doesn't have time to waste on conversation—the real thing. Too bad for her." Perhaps more to the point in today's world of global commerce, as political science professor Thierry Leterre has pointed out, France's reputation for intellectualism "is a trademark of our nation." Precisely in matters of economic competition, it's an important "comparative advantage" akin to other forms of branding, adding value to the image of the country and to what it produces by setting it apart from increasingly mindless pop culture. (As the American comedian Bill Maher said with evident appreciation, "They have public intellectuals in France—we have Dr. Phil," a TV talk-show psychologist.) The debate over whether the French are too intellectual touches on several issues that are not so much about the amount of thinking, in fact, as about who's been doing it and what those people represent, not least in the mind of Nicolas Sarkozy. France's intellectuals may not be action figures, but for more than a century, they've been recognized as activists and, in that sense, as a class apart. Although there were many on the right after the upheaval of a student revolt in France in May 1968 and the increasing radicalization of such towering figures as Jean-Paul Sartre during the same period, the intellectual class has tended to be seen popularly as on the left or far left. When the Soviet empire collapsed and Marxism was discredited in the early 1990s, many French intellectuals seemed to be cast adrift, but still held some influence over the country's political debate and its policies. The 35-hour workweek, founded on the specious intellectual argument that it would somehow reduce unemployment and increase competitiveness, is one example. So is some of the lingering anti-Americanism in French society. During Sarkozy's presidential campaign, he ran against what he described as the '68 mind-set. But Sarkozy himself is not immune to the demands of France's image as a nation of thinkers. Dartmouth professor Lawrence D. Kritzman, editor of the massive "Columbia History of Twentieth-Century French Thought," published this month, notes that the country's presidents have a long and impressive intellectual tradition. "Charles de Gaulle was quite a remarkable writer. If you look at his memoir, the knowledge of history and literature is astounding," says Kritzman. "Georges Pompidou knew the Surrealists and published an anthology of French poetry that is used in French schools to this day." Valéry Giscard d'Estaing is a member of the prestigious French Academy. François Mitterrand wrote copiously and befriended many writers. Jacques Chirac is a passionate collector of African and Asian art. Sarkozy may say that he listens to Elvis and Céline Dion instead of anything more classical or esoteric when he goes jogging, but in a smart political ploy, he decided to associate himself with a prominent intellectual. The acclaimed novelist and playwright Yasmina Reza (best known, perhaps, for her play "Art") was allowed to follow him throughout the campaign and write an unexpurgated book about it. Even if she were to massacre him, he said, he'd come out of it with his reputation enhanced. Now a best seller, Reza's "L'Aube le Soir ou la Nuit" is not always complimentary. (In one passage, Sarkozy calls Reza just before a big speech and asks her how to pronounce the last name of the great German poet Rainer Maria Rilke. She says he has it right. He's not sure and drops the name altogether.) But Sarkozy was correct about the overall effect of the book. It makes him look like a down-to-earth man of action even as it associates him with a French intellectual world he eschews: a neat trick indeed. Sarkozy may prefer to be seen as a doer rather than a thinker, but as a political tactician, he's never got a shortage of bright ideas.
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William Kelly Wallace William Kelly Wallace (1883–1969) was an Irish railway engineer who joined the Northern Counties Committee and later became Chief Civil Engineer of the London Midland and Scottish Railway (LMS). He was awarded a civil CBE in the 1946 New Year Honours. Biography William Kelly Wallace was born in 1883 and educated privately. He joined the Midland Railway Northern Counties Committee (NCC) railway in Ireland in 1906, after three years of practical training. He gained knowledge as a railway engineering, particularly in bridges inspecting all 228 bridges from Belfast to Londonderry in 1910. In 1919 he an assistant engineer to Bowman Malcolm. Although primarily a civil engineer, he was appointed to the joint positions of Locomotive Engineer and Civil Engineer on the NCC in 1922 when Bowman Malcolm retired. In 1924 he became chief engineer, a position he held till 1930. In collaboration with the Manager, James Pepper, he initiated a renewal programme in which, not only were new locomotives built, but suitable classes of older locomotives would be "heavily rebuilt", in the main following the style of the Midland Railway and, later, the London Midland and Scottish Railway (LMS). As Civil Engineer, Wallace took over the task of completing the new bridge across the River Bann at Coleraine, County Londonderry from Bowman Malcolm. This opened for traffic in March 1924. He oversaw the installation of colour light signalling at York Road station, Belfast which was commissioned in 1926. This was the first of its kind in Ireland and among the earliest large installations in the United Kingdom. Wallace devised an innovative method of constructing reinforced concrete bridges using T-section pre-cast concrete beams carried on reinforced concrete piers. Four beams created the bridge deck on to which ballasted track could be directly laid. In September 1930 he left the NCC to become Chief Stores Superintendent (Euston) on the LMS. In 1934 he became Chief Civil Engineer. Wallace was an advocate of British Standard track and flat-bottom rails and among the works he carried out were extensive trials of flat-bottom track with two types of baseplate on the former Midland and Caledonian mainlines. He also initiated an assessment of continuously welded rail (CWR). In 1946 he designed the Adam Viaduct, the first prestressed concrete railway bridge in the United Kingdom. In 1948 he left the railway service. Wallace was known for having a dry sense of humour and was popular with his colleagues. He was appointed President of the Institution of Civil Engineers for 1955–56, after being on its council and committees for 11 years. In 1949 he chaired the first meeting of its associated society, the British Geotechnical Society, and he received an honorary doctorate of science from Queen's University, Belfast in 1956. William Kelly Wallace died in Surrey in May 1969. References Further reading Currie, J.R.L. (1974) The Northern Counties Railway, Volume 2: 1903–1972, David & Charles, Newton Abbot, Ellis, Hamilton (1970) London Midland & Scottish, A Railway in Retrospect, Ian Allan Ltd., Shepperton, Category:1883 births Category:1969 deaths Category:Irish civil engineers Category:Irish mechanical engineers Category:Irish people in rail transport Category:British people in rail transport Category:London, Midland and Scottish Railway people Category:Presidents of the Institution of Civil Engineers Category:Presidents of the Smeatonian Society of Civil Engineers Category:20th-century Irish engineers
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1. The Field of the Invention The present invention relates to direct access storage drives having a rotating media. More specifically, the present invention relates to manners of improving data access in a direct access storage drive using knowledge of the particular values of off-track read capability of the heads within the drive. 2. The Relevant Technology Computer systems generally utilize auxiliary storage devices on which data can be written and from which data can be read for later use. A direct access storage device (DASD) is a common auxiliary storage device which incorporates rotating magnetic disks for storing data in magnetic form on concentric, radially spaced tracks on the disk surfaces. Transducer heads driven in a path generally perpendicular to the drive axis are used to write data to the disks and read data from the disks. Current DASDs typically utilize a head for reading or writing data onto the various tracks and an actuator connected by a support arm assembly to the head for moving the head to the desired track and maintaining it over the track centerline during read or write operations. The movement of the head to a desired track is referred to as data seeking, or merely xe2x80x9cseeking.xe2x80x9d Maintaining the head over the center line of the desired track during a read or write operation is referred to as track following or xe2x80x9ctracking.xe2x80x9d DASD systems are required to position each data head over the proper radial location for writing a track and return the data head very close to the same location when reading the track. Current DASD systems, such as hard disk drives, use a voice coil type of actuator and a control device with a feedback response to locate and consistently maintain the head over a given track. Typically, seeking and tracking are enabled by magnetically written patterns on the disk surface. The patterns generally take the form of prerecorded tracking servo marks. The servo marks are read by the transducer head and transmitted to a control unit, which utilizes the servo marks to set and correct the trajectory of the transducer head. The actuator is typically a voice coil motor (VCM) which comprises a coil movable throughout the magnetic field of a permanent magnetic stator. The application of current to the VCM causes the coil and thus the attached head to move radially. In the absence of bias forces, the acceleration of the coil is proportional to the applied current. This current is applied by a power amplifier in response to a control input. If the input control is small enough, then the applied current is proportional to the control input and the power amplifier is nonsaturated; if the control input is too large, the applied current reaches a maximum possible value, and the power amplifier is saturated. In disk files which have a relatively high density of data tracks on the disk, it is necessary to incorporate a servo control system to efficiently move the head between tracks and to maintain the head precisely over the centerline of the desired track during read or write operations. This is accomplished by utilizing prerecorded servo information either on a dedicated servo disk or on sectors angularly spaced and interspersed among the data on a data disk. The servo information sensed by the read/write head (or the dedicated servo head if a dedicated servo disk is used) is demodulated to generate a position error signal (PES) which is an indication of the position error of the head away from the nearest track centerline and to detect the track number or position sample. In a DASD digital servo control system, a microprocessor utilizes a control signal algorithm to calculate a digital control signal based upon the digital values of certain state variables such as head position, VCM current, and head velocity. The digital control signal is converted to an analog signal and amplified to provide input current to the VCM. Such a digital servo control system is described in assignee""s U.S. Pat. No. 4,679,103, incorporated by reference herein. The described system, as a part of the computation of the control signal to the actuator, makes use of the state estimator algorithm to estimate the state (i.e., position, velocity, and acceleration or current input to the VCM) of the head. In this type of system, a microprocessor receives, at discrete sample times, digital values corresponding to the PES, position sample, and the VCM input current, and computes through the use of the state estimator algorithm, a digital control signal. The digital control signal is then converted to an analog signal to provide a power amplifier control signal. A power amplifier then generates a new VCM input current. One area of system performance in which there is room for improvement is in dealing with the off-track read capability (OTRC) of a head. As the track pitch of a DASD becomes smaller, manufacturing variations of the head manifests itself as a larger relative distribution of read and write performance. Coupled with other factors, such as servo positioning or channel robustness, this distribution can be an important component of the overall system performance. Variations in head sizes that result from the manufacturing of a DASD can yield OTRC values that range from 15 to 30 percent of the track pitch. Head width is the primary variable in the OTRC of a head. Other variables, including head composition and sensitivity, spindle rotational speed, track pitch, and fly height of the head. While these latter variables must be considered, they generally do not vary within a DASD design. Also, in order to improve the overall performance of the drive, seek order scheduling is conducted to improve throughput. That is, the seeks are not performed in the order received, but the order is rearranged so that more seeks can be conducted in a given time. To best rearrange the order, the microprocessor is generally provided with a table of read and write times versus seek length to predict how long a seek will take. The prior art currently selects a single OTRC and incorporates that OTRC into its table of seek time versus seek length estimates. Only a single preselected OTRC is used for each head in a DASD and for each DASD of a given design. Generally, the OTRC value used must be a worst case or near worst case OTRC for all heads of all DASDs of the given design. Such methods have been found by the inventors to leave much room for improving seek latency. Accordingly, a need exists for an apparatus and method for applying the head-specific OTRC to seeking and tracking operations within a DASD, such that seek latency may be improved and tracking may be optimized. The apparatus of the present invention has been developed in response to the present state of the art, and in particular, in response to the problems and needs in the art that have not yet been fully solved by currently available direct access storage devices. Thus, it is an overall objective of the present invention to provide a system and method for employing off-track read capability in data access operations in a direct access storage device. To achieve the foregoing object, and in accordance with the invention as embodied and broadly described herein in the preferred embodiments, a DASD system and method for employing customized off-track read capability (OTRC) in accessing data on a direct access storage device (DASD) is provided. In one embodiment, the DASD comprises a rotating data storage medium; a read head positionable for interaction with the data storage medium; and a control unit for positioning the read head with respect to the data storage medium. Preferably, the control unit comprises an off-track read capability (OTRC) storage module configured to store an indicator of an OTRC particular to the read head and an access module configured to apply the OTRC in accessing data from the data storage medium. The data access module is, in one embodiment, configured to apply the OTRC to generate an improved read time estimate for optimal scheduling of data operations. The OTRC is preferably measured during manufacturing of the DASD. In one embodiment, the access module comprises a seek module configured to apply the OTRC dynamically during a data seeking operation, while in another embodiment, the access module comprises a tracking module configured to apply the OTRC dynamically during a data tracking operation. In applying the OTRC in the data seeking operation, it is used to calculate an improved estimate of read time. This estimate can then be employed directly in conducting the seek operations, or may be employed in queuing seeks in random queued data access operations. The control unit may comprise a servo control loop that uses the OTRC to determine a seeking control and/or a tracking control law. The parameters of the servo control in one embodiment are changed by applying the OTRC. In one embodiment, the control unit comprises a data seek algorithm and is configured to apply the OTRC to the data seek algorithm to determine an optimal trajectory of the head to the target data. A queuing module may be provided within the control unit and may be configured to apply the OTRC in ordering a random queued seek operation. In one embodiment, the OTRC storage module comprises a table of time-to-data values for various numbers of tracks traversed, the table incorporating the OTRC specific to the head. In an alternative embodiment, the OTRC storage module comprises a standard table of time-to-data values for various numbers of tracks traversed and an adder corresponding to the OTRC. In yet another embodiment, the OTRC storage module comprises a plurality of tables of time-to-data for various numbers of tracks traversed, each of the plurality of tables specific to an OTRC or range of OTRC. The DASD may, in one embodiment, also be provided with a buffer memory in communication with the control unit, an OTRC indicator particular to each read head, the OTRCs stored in the buffer memory, and a queuing module disposed within the control unit. Preferably, the queuing module is configured to receive a queue of target data to be accessed from the data storage medium into the control unit, determine the physical locations of the target data, access the specific OTRCs for one or more heads involved, determine, using the one or more OTRCs and the physical target location and the physical starting location, which of the target data can be accessed most quickly, and access said target data that can be accessed most quickly prior to the other target data. The OTRC indicator particular to each read head may comprise a table specific to the head, the table containing access times for various amounts of tracks to be traversed in accessing target data. Alternatively, the OTRC indicator particular to each read head may comprise an adder specific to the head stored within buffer memory. Accordingly, the queuing module is, in this embodiment, configured to consult a table containing nominal access times for various amounts of tracks to be traversed in accessing target data, extract a time-to-data value from the table, reference the adder, and add the adder to the time-to-data value. The access module may comprise a seeking module disposed within the control unit. In one embodiment, the seeking module is configured to receive a physical address of target data, receive the OTRC of the head involved in accessing the target data, and apply the OTRC to pick the optimal seek and/or tracking parameters for that OTRC. The seek is then performed to access the data at the target location. An attendant method for employing customized off-track read capability (OTRC) in accessing data on a direct access storage device (DASD) comprises providing a DASD having a rotating data storage medium and a read head positionable for interaction with the data storage medium, determining the OTRC particular to the read head, and applying the OTRC in accessing data from the data storage medium. Applying knowledge of the OTRC in accessing data from the DASD may comprise applying the OTRC dynamically during a seek operation and may also comprise applying the OTRC dynamically during a tracking operation. In one embodiment, determining the OTRC comprises measuring the OTRC of the read head during manufacturing of the DASD. The method may further comprise providing a servo control loop within the DASD, and applying the OTRC in accessing data from the data storage medium may comprise applying the OTRC within the servo control loop. Preferably, the OTRC is applied to determine an optimal servo loop for seeking and/or tracking. In one embodiment, applying the OTRC comprises applying the OTRC to a data seek algorithm to determine an optimal trajectory of the head to the target data. In yet another embodiment, applying the OTRC comprises applying the OTRC to a seek queuing algorithm to determine the order of seeking a plurality of blocks of target data by improving the read time estimates. Applying the OTRC may also comprise referencing a table of time-to-data for various numbers of tracks traversed, the table incorporating the OTRC specific to the head. Additionally, applying the OTRC may comprise referencing a standard table of time-to-data values for various numbers of tracks traversed and applying an adder corresponding to the OTRC. Applying the OTRC may also comprise referencing from among a plurality of tables of time-to-data for various numbers of tracks traversed, each of the plurality of tables specific to a OTRC, a table with an OTRC specific to the head. Under an additional embodiment, the DASD comprises a plurality of read heads and determining the OTRC particular to the read head comprises measuring the OTRC of each of the plurality of read heads and recording the OTRCs on a reserved area on the data storage medium. In this embodiment, applying the OTRC in accessing data from the data storage medium comprises providing a control unit having access to a buffer memory within the DASD, transferring the OTRCs from the reserved area to the buffer memory, receiving a queue of target data to be accessed from the data storage medium into the control unit, determining the physical locations of the target data, accessing the specific OTRCs for one or more heads involved, determining, using the one or more OTRCs, which of the target data can be accessed most quickly, and accessing said target data that can be accessed most quickly prior to the other target data. In one embodiment, the transfer of data to the buffer area from the reserved area happens only at the spin up of the drive. Under this embodiment, accessing the specific OTRCs for one or more heads involved comprises consulting a table specific to the head, the table containing access times for various amounts of tracks to be traversed in accessing target data. Alternatively, accessing the specific OTRCs for one or more heads involved may comprise consulting a table containing nominal access times for various amounts of tracks to be traversed in accessing target data, extracting a time-to-data value from the table, referencing an adder specific to the head stored within buffer memory, and adding the adder to the time-to-data value. In another embodiment, the DASD comprises a plurality of read heads. Determining the OTRC particular to the read head comprises measuring the OTRC of each of the plurality of read heads and recording the OTRCs on a reserved area on the data storage medium. Applying the OTRC in accessing data from the data storage medium comprises providing a control unit having access to a buffer memory within the DASD, an actuator arm for transporting the head across the data storage medium, and a voice coil motor for powering the arm. The method in this embodiment further comprises transferring the OTRCs from the reserved area to the buffer memory, receiving a block of target data to be accessed from the data storage medium into the control unit, determining the physical locations of the target data, accessing the specific OTRC for a head involved in accessing the target data, and calculating, using the OTRC of the involved head, an amount of current to transmit to the arm to transport the head to the target data with an optimized trajectory.
{ "pile_set_name": "USPTO Backgrounds" }
name: "ris80_h2_VGG_ILSVRC_19_rgb2imNet" input: "data" input_dim: 10 input_dim: 3 input_dim: 224 input_dim: 224 layers { bottom: "data" top: "conv1_1" name: "conv1_1" type: CONVOLUTION convolution_param { num_output: 64 pad: 1 kernel_size: 3 } } layers { bottom: "conv1_1" top: "conv1_1" name: "relu1_1" type: RELU } layers { bottom: "conv1_1" top: "conv1_2" name: "conv1_2" type: CONVOLUTION convolution_param { num_output: 64 pad: 1 kernel_size: 3 } } layers { bottom: "conv1_2" top: "conv1_2" name: "relu1_2" type: RELU } layers { bottom: "conv1_2" top: "pool1" name: "pool1" type: POOLING pooling_param { pool: MAX kernel_size: 2 stride: 2 } } layers { bottom: "pool1" top: "conv2_1" name: "conv2_1" type: CONVOLUTION convolution_param { num_output: 128 pad: 1 kernel_size: 3 } } layers { bottom: "conv2_1" top: "conv2_1" name: "relu2_1" type: RELU } layers { bottom: "conv2_1" top: "conv2_2" name: "conv2_2" type: CONVOLUTION convolution_param { num_output: 128 pad: 1 kernel_size: 3 } } layers { bottom: "conv2_2" top: "conv2_2" name: "relu2_2" type: RELU } layers { bottom: "conv2_2" top: "pool2" name: "pool2" type: POOLING pooling_param { pool: MAX kernel_size: 2 stride: 2 } } layers { bottom: "pool2" top: "conv3_1" name: "conv3_1" type: CONVOLUTION convolution_param { num_output: 256 pad: 1 kernel_size: 3 } } layers { bottom: "conv3_1" top: "conv3_1" name: "relu3_1" type: RELU } layers { bottom: "conv3_1" top: "conv3_2" name: "conv3_2" type: CONVOLUTION convolution_param { num_output: 256 pad: 1 kernel_size: 3 } } layers { bottom: "conv3_2" top: "conv3_2" name: "relu3_2" type: RELU } layers { bottom: "conv3_2" top: "conv3_3" name: "conv3_3" type: CONVOLUTION convolution_param { num_output: 256 pad: 1 kernel_size: 3 } } layers { bottom: "conv3_3" top: "conv3_3" name: "relu3_3" type: RELU } layers { bottom: "conv3_3" top: "conv3_4" name: "conv3_4" type: CONVOLUTION convolution_param { num_output: 256 pad: 1 kernel_size: 3 } } layers { bottom: "conv3_4" top: "conv3_4" name: "relu3_4" type: RELU } layers { bottom: "conv3_4" top: "pool3" name: "pool3" type: POOLING pooling_param { pool: MAX kernel_size: 2 stride: 2 } } layers { bottom: "pool3" top: "conv4_1" name: "conv4_1" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv4_1" top: "conv4_1" name: "relu4_1" type: RELU } layers { bottom: "conv4_1" top: "conv4_2" name: "conv4_2" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv4_2" top: "conv4_2" name: "relu4_2" type: RELU } layers { bottom: "conv4_2" top: "conv4_3" name: "conv4_3" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv4_3" top: "conv4_3" name: "relu4_3" type: RELU } layers { bottom: "conv4_3" top: "conv4_4" name: "conv4_4" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv4_4" top: "conv4_4" name: "relu4_4" type: RELU } layers { bottom: "conv4_4" top: "pool4" name: "pool4" type: POOLING pooling_param { pool: MAX kernel_size: 2 stride: 2 } } layers { bottom: "pool4" top: "conv5_1" name: "conv5_1" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv5_1" top: "conv5_1" name: "relu5_1" type: RELU } layers { bottom: "conv5_1" top: "conv5_2" name: "conv5_2" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv5_2" top: "conv5_2" name: "relu5_2" type: RELU } layers { bottom: "conv5_2" top: "conv5_3" name: "conv5_3" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv5_3" top: "conv5_3" name: "relu5_3" type: RELU } layers { bottom: "conv5_3" top: "conv5_4" name: "conv5_4" type: CONVOLUTION convolution_param { num_output: 512 pad: 1 kernel_size: 3 } } layers { bottom: "conv5_4" top: "conv5_4" name: "relu5_4" type: RELU } layers { bottom: "conv5_4" top: "pool5" name: "pool5" type: POOLING pooling_param { pool: MAX kernel_size: 2 stride: 2 } } layers { bottom: "pool5" top: "fc6" name: "fc6" type: INNER_PRODUCT inner_product_param { num_output: 4096 } } layers { bottom: "fc6" top: "fc6" name: "relu6" type: RELU } layers { bottom: "fc6" top: "fc6" name: "drop6" type: DROPOUT dropout_param { dropout_ratio: 0.5 } } layers { bottom: "fc6" top: "fc7" name: "fc7" type: INNER_PRODUCT inner_product_param { num_output: 4096 } } layers { bottom: "fc7" top: "fc7" name: "relu7" type: RELU } layers { bottom: "fc7" top: "fc7" name: "drop7" type: DROPOUT dropout_param { dropout_ratio: 0.5 } } layers { name: "fc8_ris80h2ilsvrc12rgb2im" type: INNER_PRODUCT bottom: "fc7" top: "fc8_ris80h2ilsvrc12rgb2im" # blobs_lr is set to higher than for other layers, because this layer is starting from random while the others are already trained blobs_lr: 10 blobs_lr: 20 weight_decay: 1 weight_decay: 0 inner_product_param { num_output: 385 weight_filler { type: "gaussian" std: 0.01 } bias_filler { type: "constant" value: 0 } } } layers { bottom: "fc8_ris80h2ilsvrc12rgb2im" top: "prob" name: "prob" type: SOFTMAX }
{ "pile_set_name": "Github" }
Do cats really have nine lives or is it just a myth? This is a good question for discussing how metaphors and other figures of speech function in using language to convey ideas. As with any complex organism like mammals, there is an important, even (as the word implies) a vital connection between blood circulation and brainwave function, and whatever criteria you use to determine the termination of life, it is an irreversible process. When we say that a cat has nine lives, we are actually referring to its agility, it's ability to cushion a fall with its limbs, its ability to crawl through small spaces,etc., so that they give an appearance of surviving deadly experiences. Language "flattens" this idea, here with the soft verb "have". Today the saying has achieved "cliche" status, and fills a space in an utterance without demanding fresh expression.
{ "pile_set_name": "Pile-CC" }
Life Like Movie Stills #2 - Late Night Walk "Life Like Movie Stills" is an ongoing photo project that tries to emulate the feeling of watching a movie through the cinemascope aspect and acting. "Late Night Walk" tells the story of a photographer walking around an isolated village at night, looking for inspiration.
{ "pile_set_name": "Pile-CC" }
#ifndef BILINEARPROCESSOROCL_H #define BILINEARPROCESSOROCL_H #include "IProcessorOCL.h" class BilinearProcessorOCL : public IProcessorOCL { private: void* _redChannel; void* _greenChannel; void* _blueChannel; unsigned int _width; unsigned int _height; unsigned long _size; cl::Kernel* _kernels; cl::NDRange _globalSizes; cl::NDRange _localSizes; cl::NDRange _verticalSize; cl::NDRange _horizontalSize; cl::NDRange _greenOffsets; cl::NDRange _greenSizes; // Varies accordingly to pattern. cl::NDRange _redOffsets, _redVerticalOffsets, _redHorizontalOffsets; cl::NDRange _blueOffsets, _blueVerticalOffsets, _blueHorizontalOffsets; cl::Buffer _redBuffer; cl::Buffer _greenBuffer; cl::Buffer _blueBuffer; public: virtual std::string GetKernelFilePath() override; virtual void GetArguments(cl::Context& context, OC::Image::OCImage& image, cl::Kernel kernels[6]) override; void GetKernelsStrings(OC::Image::BayerPattern pattern, std::string kernelsStrings[6]) override; void Process(cl::CommandQueue& queue) override; void* GetRedChannel() override; void* GetGreenChannel() override; void* GetBlueChannel() override; }; #endif // BILINEARPROCESSOROCL_H
{ "pile_set_name": "Github" }
Devices for removing at least the crop from slaughtered poultry, also known as crop removers or (de)croppers, are known among others from the applicant's firm and from European patent application 0.162.254 and U.S. Pat. No. 5,178,578, for example. A suchlike crop remover is installed downstream from an eviscerating machine. In the crop remover, with the help of a rotating crop probe which passes into the poultry carcass via the vent, the whole crop and the trachea as well as everything else attached to the neck is removed. The crop remover is subsequently removed through the opposite neck opening of the carcass in order to permit delivery of the loosened parts to a tray placed under that and to be cleaned, after which the crop remover can be retracted again to an out-of-operation position. In slaughter lines, in particular in the so-called eviscerating lines, a number of stations are arranged after the crop remover, such as station where the neck is broken, a station where the inside of the carcass is cleaned and a station where the outside of the carcass is cleaned. Applicant already offers for sale a neck breaker, which breaks the neck and in one embodiment removes it without unnecessarily damaging the skin of the neck and in another embodiment removing the neck together with the skin of the neck. For this reference can be made to the applicant's Dutch patent application 79.04779. In addition, a combination neck breaker/final control machine is part of the applicant's delivery programme, in which not only the neck is broken but also the inside of the carcass is sucked clean. With the help of a pipe provided with a slanting end introduced from above, the lungs and other parts not suitable for consumption, which remained behind after evisceration, are removed. In addition, the applicant has an automatic inside-outside washer, in which the outside of the carcasses is cleaned with sprayers, while the inside is washed by means of a water tube with a special mouth piece. Finally, a combined crop remover/inside-outside washer can be mentioned, in which the inside of the carcasses is washed with the help of spray water supplied via the crop probe.
{ "pile_set_name": "USPTO Backgrounds" }
Q: Error: expected specifier-qualifier-list before ‘TR’ I have a problem defining my structure inside the union on Bison I made a structure typedef enum {Binary_Op,Uni_Op,Variable, Const} Tag_Type; typedef struct tree { Tag_Type Tag; union { struct { char op; struct tree *left, *right; }bin_op; struct { char op; struct tree *arg; /* negative or positive */ }uni_op; char var; int const_val; }u; }TREE_REC, *TR; %} %union { int y_int; TR y_tree; } %type <y_tree> expr term factor assign %token <y_int> CONST %token <y_int> VAR %% but inside the union TR has an error. I don't understand why!! any help? A: You need to define struct tree and TR in a header file that you #include before you #include "y.tab.h". The error message is telling you that you're trying to use TR before the compiler has seen a definition for it. A: I'm a bit confused with your typedef struct tree {...} TREE_REC, *TR. I would have rather written : typedef struct tree {...} TREE_REC; //Alias on struct tree typedef TREE_REC * TR; //Definition of the pointer to a struct tree The , in your typedef is disturbing me. Can you test my solution, or just clarify the syntax of your typedef?
{ "pile_set_name": "StackExchange" }
Effect of in utero irradiation on the postnatal development, behavior, and brain structure of rats: dose fractionation with a 6-h interval. Based on previous studies showing that exposure of the rat fetus to ionizing radiation produces dose-dependent (0.25-1.25 Gy) changes in postnatal development of behavior and decreases in the thickness of the cerebral cortex, we examined the extent to which dose fractionation would reduce expression of damage. Pregnant rats were exposed to single doses of 0.5 or 1.0 Gy, or to two doses of 0.5 Gy 6 h apart on day 15 of gestation. Offspring were subjected to four behavioral tests on postnatal days 7-28; the rats were then sacrificed and their brains removed and processed for histology. For all end points, the fractionated dose produced an effect that was intermediate between that of the 0.5- and 1.0-Gy doses and which, by interpolation, could be expressed as equivalent to a single dose between 0.5 and 1.0 Gy. The equivalent single dose was not significantly different from the 1.0-Gy dose for negative geotaxis (0.54 Gy), reflex suspension (0.80 Gy), and continuous corridor (0.85 Gy). For sine of the angle of the advance of hind feet (0.58 Gy), width of stride (0.69 Gy), length of stride (0.75 Gy), body weight (0.73 Gy), and cerebral cortex thickness (0.69 Gy), the fractionated dose produced effects significantly different (P < 0.05) from the 1.0-Gy dose. Overall, exposure of fetal rats to two doses of 0.5 Gy separated by 6 h produced effects equivalent to a single dose of 0.70 Gy, as measured by postnatal behavioral tests and morphological assessment of brain structure.
{ "pile_set_name": "PubMed Abstracts" }
NEW DELHI: BJP leader Subramanian Swamy on Friday termed Rahul Gandhi 's hug to Prime Minister Narendra Modi a "childish act" and said Parliament will become a "chaotic place" if other members also start doing so. "It was very juvenile behaviour and if everybody starts doing so then Parliament will become a chaotic place. The Lok Sabha Speaker is right as decorum has to be maintained in the House," Swamy told reporters on the sidelines of an event. After a no-holds barred and scathing criticism of Modi on several issues including Rafale jet deal, Congress president Rahul Gandhi walked across to the prime minister and hugged him, a gesture which took the Lok Sabha members by surprise. Modi, who initially looked nonplussed and did not stand up to hug him, recovered quickly and called Gandhi back and patted him on the back. "This is what it means to be a Hindu," Gandhi said after coming back to his seat amid a big applause from his party members, including his mother Sonia Gandhi and other leaders present.
{ "pile_set_name": "OpenWebText2" }
Q: How to sort a Map[string]int by its values? Given this code block map[string]int {"hello":10, "foo":20, "bar":20} I would like to print out foo, 20 bar, 20 hello, 10 In the order of highest to lowest Thanks! A: Found the answer on Golang-nuts by Andrew Gerrand You can implement the sort interface by writing the len/less/swap functions func rankByWordCount(wordFrequencies map[string]int) PairList{ pl := make(PairList, len(wordFrequencies)) i := 0 for k, v := range wordFrequencies { pl[i] = Pair{k, v} i++ } sort.Sort(sort.Reverse(pl)) return pl } type Pair struct { Key string Value int } type PairList []Pair func (p PairList) Len() int { return len(p) } func (p PairList) Less(i, j int) bool { return p[i].Value < p[j].Value } func (p PairList) Swap(i, j int){ p[i], p[j] = p[j], p[i] } For the original post, please find it here https://groups.google.com/forum/#!topic/golang-nuts/FT7cjmcL7gw A: There's a new sort.Slice function in go 1.8, so now this is simpler. package main import ( "fmt" "sort" ) func main() { m := map[string]int{ "something": 10, "yo": 20, "blah": 20, } type kv struct { Key string Value int } var ss []kv for k, v := range m { ss = append(ss, kv{k, v}) } sort.Slice(ss, func(i, j int) bool { return ss[i].Value > ss[j].Value }) for _, kv := range ss { fmt.Printf("%s, %d\n", kv.Key, kv.Value) } } https://play.golang.org/p/y1_WBENH4N A: For example: package main import ( "fmt" "sort" ) func main() { m := map[string]int{"hello": 10, "foo": 20, "bar": 20} n := map[int][]string{} var a []int for k, v := range m { n[v] = append(n[v], k) } for k := range n { a = append(a, k) } sort.Sort(sort.Reverse(sort.IntSlice(a))) for _, k := range a { for _, s := range n[k] { fmt.Printf("%s, %d\n", s, k) } } } Playground Output: foo, 20 bar, 20 hello, 10
{ "pile_set_name": "StackExchange" }
Posted by samzenpus on Wednesday February 26, 2014 @10:03PM from the look-at-the-bones dept. sciencehabit writes "In 2010, workers widening a remote stretch of highway near the northwestern coast of Chile uncovered a trove of fossils, including the skeletons of at least 30 large baleen whales. The fossils—which may be up to 9 million years old—are the first definitive examples of ancient mass strandings of whales, according to a new study. The work also fingers a possible culprit." 'Oceanic algal bloom' is a credible proposition (though there wasn't any of the palynological or micropalaeontological evidence that one could reasonably have hoped for, and there is evidence of fairly active current movement, which doesn't really help an algal bloom hypothesis). But volcanic gas clouds (e.g. a sulphide-rich ignimbrite projecting out into the bay) is also credible. At this time, the cause of death isn't clear, and there are multiple credible possibilities. If you RTFP [royalsocie...ishing.org] (it is Open Access ; use it, or lose it!) you'll find that the original researchers don't take that paradigm. They're not at all clear about why the whales died, and think that many of the died and hit the seabed in depths of tens to a hundred or so metres (various lines of evidence : sediment patterns, levels of seabed life ; nearby unambiguous shoreline deposits ; constraints on the angle of slope of the seabed for sediment stability). Though parts of the sequence of beds in which the whales were found were definitely emergent (above sea level) at times, that's not considered the case for the particular beds (plural ! They represent thousands, if not tens of thousands, of years of repeated events.) in which the whale fossils have been found. TFP isn't confused. The coverage by a journalist working for Science Magazine may be. (I RTFP a few days ago, and promoted it to several geological discussion lists.)
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Esses eventos naturais brilhantes e chamativos são raros e impressionantes. Para você presencia-los pessoalmente, terá que ter sorte e chegar na hora exata. O arco-íris é um dos fenômenos mais incríveis da natureza. Pixabay/Domínio Público. VAMOS DESCOBRIR... Viagens coloridas podem leva-lo a murais de rua ou cidades lindas, mas quando se trata de espetáculos verdadeiramente únicos e vibrantes, a natureza é capaz de produzir os momentos mais inspiradores da Terra. Quer seja graças à bioluminescência , aos padrões de migração anuais, ou apenas a fortes tempestades, esses fenômenos podem ser frequentemente difíceis de saber quando e onde aconteceram. Por isso aqui terá para você um vislumbre da natureza em fenômenos fantásticos que colorem o mundo. Vamos descobrir: A MIGRAÇÃO DAS BORBOLETAS MONARCAS Em dias calmos, as árvores ganham vida com o as asas de milhões de borboletas monarcas. Foto: Joel Sartore, National Geographic Creative. Milhões de borboletas monarcas fazem a migração anual para o sul de Canadato, no México, durante o inverno, onde transformam os abetos de Michoacán em uma exposição de arte natural viva e respirável. No entanto, a verdadeira explosão de cor ocorre quando elas acordam do sono nos pinheiros, voando pelo ar, transformando suas asas laranjas e pretas ricamente pigmentadas em uma pincelada cor de tangerina. Quando e onde ver as borboletas: entre janeiro e março, em dias calmos e quentes, no México. Leia também: Um show de cores: borboletas fantásticas VAGA-LUMES SINCRÔNICOS Ao menos 19 espécies de vaga-lumes vivem no Parque Nacional Great Smoky Mountains , mas apenas uma dessas espécies é capaz de sincronizar seu show de luz hipnotizante. Foto: David Liittschwager, National Geographic Creative. Uma vez por ano, como parte de seus rituais de acasalamento, os vaga-lumes de Smoky Mountains fazem um dos shows de luzes mais deslumbrantes e frustrantemente impossíveis de prever. Enquanto a maioria dos vaga-lumes não conseguem sincronizar o brilho de suas barrigas bioluminescentes, essa espécie faz disso uma arte, proporcionando aos visitantes um espetáculo de brilhos harmoniosos que ondulam pelas montanhas. Uma vez determinadas, as datas são anunciadas no site oficial, mas a concorrência é alta para se candidatar para uma vaga. Quando e onde ver esses vaga-lumes: de final de maio a meados de junho nos EUA. Leia também: Os cupinzeiros bioluminescentes CAÑO CRISTALES Estas plantas vivem no leito do rio durante todo o ano, mas mostram suas cores brilhantes quando as condições estão perfeitas. Foto: Thomas Marent, Minden Pictures. No norte da Colômbia, este rio deslumbrante recebe uma explosão de cores produzidas por uma planta aquática digna de seu nome. As cores caleidoscópicas cobrem o leito do rio Caño Cristales , dando a impressão de que a água está fluindo sobre a paleta de um artista. Com cores variando de vermelho terra a amarelo mostarda e lilás, deve ser visto para se acreditar. Quando e onde ver esse rio: de junho a novembro, na Colômbia. MIGRAÇÃO DO CARANGUEJO VERMELHO Milhares de jovens caranguejos cobrem as rochas da ilha Christmas. Foto: Warerframe/Alamy Stock Photo. Todos os anos durante a temporada de acasalamento, a população de caranguejos vermelhos da ilha Christmas deixa o berço e dirige-se para a costa, enfrentando estradas na companhia de multidões de pessoas que acompanham a caminhada. Recentemente, pontes e passarelas foram especialmente construídas para ajudar os caranguejos a evitar esmagamentos acidentais, mas prever as datas em que esses crustáceos de casca escarlate iniciarão a migração é complicado, uma vez que seguem não só o calendário lunar, mas também a estação úmida e das chuvas pesadas. Quando e onde ver os caranguejos : no início da estação úmida, em outubro ou novembro, na Ilha Christmas, Austrália. O DESERTO FLORIDO Esta superfloração é única e rara, fazendo com que os anos de chuvas fortes sejam uma ótima razão para marcar uma viagem para ver o deserto colorido. Foto: Andrea Dominguez, Getty Images. As super florações fazem aparições agendadas em todo o mundo, seja nos campos de canola da China ou nos desertos de Namaqualand. Por outro lado, no Atacama chileno – o deserto mais seco do mundo – as superflorações são menos que previsíveis. Na verdade, somente quando o volume de chuva é incomumente alto (geralmente graças ao El Niño), as planícies normalmente estéreis explodem em vida com uma variedade de flores multicoloridas. Quando e onde ver a superfloração: De setembro a novembro, mas somente quando os níveis de chuva são muito altos, no Chile. Leia também: As flores mais cheirosas do mundo AURORA BOREAL As auroras boreais da Noruega estão entre as melhores do hemisfério norte. Foto: Getty Images. As pinturas espaciais que colorem o céu da noite de alguns dos destinos mais ao norte do globo não são tão raras. Na verdade, a Noruega é um dos melhores pontos para ver as auroras boreais anualmente, embora as faixas verdes sejam mais fáceis de serem vistas, você terá que cruzar os dedos para ver as raríssimas luzes vermelhas. Quando e onde ver as auroras boreais : de final de setembro ao final de março, na Noruega. Leia também: Auroras e outras manifestações do campo geomagnético A DESOVA DOS CORAIS, AUSTRÁLIA Todos os anos, os recifes de coral sob as ondas de Ningaloo na Austrália Ocidental desovam em sincronia, liberando minúsculos óvulos que flutuam até a superfície da água. Foto: Look/Alamy Stook Photo. Os recifes de corais da Austrália são, possivelmente, um dos fenômenos naturais mais coloridos do mundo por si só, mas esses mundos subaquáticos têm uma carta ainda mais impressionante em sua manga – a desova dos corais. Descrita como uma tempestade de neve subaquática e antigravitacional, cada ano os recifes de coral sob as ondas de Ningaloo, na Austrália Ocidental, desovam em sincronia, liberando minúsculos óvulos que flutuam até a superfície. Quando e onde ver a desova dos corais: até uma semana após a lua cheia, normalmente no outono, na Austrália. Leia também: O colorido mundo dos corais AS LULAS BRILHANTES DA BAÍA DE TOYAMA Durante a época de acasalamento, as lulas vaga-lume sobem até a superfície e proporcionam um show logo antes do nascer do sol. Foto: Mark Macewen, Nature Picture Library/Getty Images.
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Q: How to make smooth change of css property while scrolling? I have a task - my navigation block has background property background: rgba(0,0,0, 0); I need to smooth change its opacity from 0 to 1 while scrolling, its no problem, but the end of animation (i mean the moment when opacity of background will reach 1) is bottom border of some block so this is my HTML code <header> <nav>...</nav> </header> header has a flexible height. nav has a height of 100px. So i need my nav`s background opacity to reach 1 when scrollTop value will be: $('header').height() - $(nav).height(); https://jsfiddle.net/zzvns9hy/7/ A: You can do something like HTML <header> <nav></nav> </header> CSS nav { width:100px; height:100px; } SCRIPT $(window).scroll(function() { // what is the position of nav from the top of the document var NavTop = Math.floor( $(document).scrollTop() - $('nav').offset().top ); // From 0 to 1, how much is nav scrolled var NavScroll = NavTop / $('nav').height(); $('nav').css('background-color','rgba(255,0,0,'+NavScroll+')'); }); http://jsfiddle.net/an50e93p/
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65 Ill.2d 244 (1976) 357 N.E.2d 530 HELEN W. WALLING, Appellant, v. KAREN LINGELBACH et al. — (Lottie Strahorn, Appellee.) No. 48188. Supreme Court of Illinois. Opinion filed November 24, 1976. North, North & Ohlson and Charles H. Davis, both of Rockford (Larry E. Ohlson, of counsel), for appellant. Maynard, Brassfield & Cowan, of Rockford (Eugene E. Brassfield, of counsel), for appellee. Judgment affirmed. *245 MR. JUSTICE KLUCZYNSKI delivered the opinion of the court: Helen Walling, plaintiff, was seriously injured when the automobile in which she was riding collided head on with an approaching vehicle driven by Karen Lingelbach. At trial, the jury found both drivers guilty of negligence, and the circuit court of Winnebago County entered a judgment on the verdict against both defendant drivers in favor of plaintiff for $82,500. Lottie Strahorn, the driver of the vehicle in which Walling was a passenger, appealed and the appellate court reversed without remandment, holding that the evidence was insufficient to sustain any verdict for Walling against Strahorn. (33 Ill. App.3d 949.) Defendant Lingelbach, however, did not appeal. We granted Walling leave to appeal in which she contends that there was sufficient evidence to allow this case to go to the jury and to sustain a jury verdict under the rule stated in Pedrick v. Peoria and Eastern R.R. Co., 37 Ill.2d 494, 513. She also contends that the appellate court improperly substituted its opinion for that of the jury and trial judge on the credibility of witnesses, the conflicts in the evidence and the weight of evidence, and ignored the jury's findings of proximate cause. The following facts were presented at trial: On November 14, 1973, at 6:20 a.m., Lottie Strahorn was driving her husband and Helen Walling to work. She was traveling northbound on Springfield Avenue, a paved two-lane highway, at approximately 30 to 35 miles per hour. At the same time, Lingelbach was alone in her vehicle, driving southbound on the same road. The day was hazy with intermittent patches of fog ranging from light to very heavy. Strahorn testified that the visibility averaged 25 feet except in areas of heavy fog, where visibility was greatly reduced. Lingelbach observed that the fog got heavier as she traveled further south. Both drivers claimed *246 to have had their headlights on. Lingelbach stated that she was in the right lane and was traveling 50 miles per hour when she entered an intersection 700 feet north of the collision. However, she did not know in which lane the collision occurred. She first saw the other vehicle when it was three or four feet in front of her, and she immediately swerved left just before impact. Strahorn testified that Lingelbach's vehicle was in the southbound lane, but just prior to the collision entered her lane. At this time she exclaimed, "Look at that crazy fool, he must be drunk!" Then she applied her brakes, slowed down, and made a right turn onto the shoulder. Lingelbach's car was 10 feet away when last observed by Strahorn. Her exclamation was somewhat corroborated by Walling's testimony relating that Strahorn stated, "They are going to hit us!" However, Strahorn's husband, also a passenger, had no recollection that his wife made this statement. The two officers that had responded to the call regarding the accident testified that visibility was very poor due to fog and that the pavement was damp. One of the officers, John Markley, observed that Lingelbach's vehicle was facing south on the east shoulder of Springfield Avenue and Strahorn's car was facing north but positioned southeast of the other automobile. No skid marks were found on the road. Markley observed glass and debris from the crushed headlights, and turn signals were scattered in the northbound lane and formed a two-foot circle with a quarter section missing. The center of the circle was one or two feet west of the edge of the pavement, 727 feet south of the intersection, and 58 feet north of the right front tire of defendant's vehicle. The distance between the vehicles after the collision was measured at 264 feet, but Markley, believing the measurement to be a miscalculation, stated that the actual distance was closer to 150 feet. He further observed that no windshields were broken and no glass or debris *247 was found within the proximity of the vehicles or in the southbound lane. The only statement he recalled having been made by parties to the accident was Strahorn saying something to the effect that she looked up and saw the car coming at her. However, she did not remember making any statements to police. Also he noted that neither party knew what happened. A co-worker of both Walling and Strahorn's husband testified that the former, while in the hospital, made the statement that the accident was not Strahorn's fault. This statement was also heard by Strahorn's niece, but Walling denied making this statement. Strahorn's husband stated that he saw the other vehicle "one block away" just prior to the accident, that it had crossed the center lane and was traveling in the middle of the road. He further testified that the fog was light where the collision occurred. In Pedrick v. Peoria and Eastern R.R. Co., 37 Ill.2d 494, 504-05, before formulating its rule governing directed verdicts and judgments, this court observed: "* * * the presence of some evidence of a fact which, when viewed alone may seem substantial, does not always, when viewed in the context of all of the evidence, retain such significance. * * * Constitutional guaranties are not impaired by direction of a verdict despite the presence of some slight evidence to the contrary * * *." With the above as its premise the court presented the following rule: "In our judgment verdicts ought to be directed and judgments entered only in those cases in which all of the evidence, when viewed in its aspect most favorable to the opponent, so overwhelmingly favors movant that no contrary verdict based on that evidence could ever stand." (Emphasis added.) 37 Ill.2d 494, 510. Under the Pedrick rule, we view all the evidence in a *248 light most favorable to Walling. We cannot speculate and will not supply facts in void areas to complete the reconstruction of an accident. The controlling issue in this case is in which lane the collision occurred. If both vehicles had remained in their respective lanes, the accident would not have happened. Conversely, the collision would not have occurred but for one vehicle having crossed the center line. Lingelbach admitted that she did not know in which lane she was at the time of impact, whereas both Mr. and Mrs. Strahorn testified that their automobile never crossed into the southbound lane and that the oncoming vehicle crossed the center line when it approached them. This testimony was not refuted or contradicted. There was no evidence presented that Strahorn was in the improper lane, that the impact occurred in the southbound lane, or that both drivers straddled the center line. All the debris discovered was found scattered on the far eastern portion of the northbound lane. Credibility of witnesses has minimum import in this case. The lack of evidence supporting Walling's case exists whether or not the jury believed Mr. and Mrs. Strahorn's testimony. Although Walling argued that it could be inferred that Strahorn was negligent by exercising improper control and lookout and by speeding, none of these alleged acts were the proximate cause of appellant's injury. We feel that the jury abandoned the domain of allowable inferences and entered the area of speculation in determining that Strahorn's negligence was one of the proximate causes of Walling's injury. Therefore, under these circumstances we hold that the appellate court properly applied the rule expressed in Pedrick in concluding that the evidence was insufficient to present a jury question. Accordingly, we affirm the judgment of the appellate court. Judgment affirmed.
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Ever since the invention of the first scanning probe microscope in 1981, researchers have believed the powerful tool would someday be used for the nanofabrication and nanopatterning of surfaces in a molecule-by-molecule, bottom-up fashion. Despite 25 years of research in this area, the world has hit a brick wall in developing a technique with commercial potential — until now. Northwestern University researchers have developed a 55,000-pen, two-dimensional array that allows them to simultaneously create 55,000 identical patterns drawn with tiny dots of molecular ink on substrates of gold or glass. Each structure is only a single molecule tall. Only a single molecule tall, but 80 nanometers wide, so the “molecule-by-molecule” phrasing above is too optimistic for now. Meanwhile over at IBM Almaden they’re looking instead (or in addition) at DNA, as reported at the DEMO conference in San Diego: …an IBM executive touted the potential capabilities of nanotechnology in storage devices. “Nanotechnology is going to affect that in a very dramatic way,” said Gian-Luca Bona, department group manager of Science & Technology at IBM’s Almaden Research Center, in California. One idea being considered for building devices as small as five-by-five nanometers involves the concept of using DNA-based molecular strands, Bona said. “It’s all about scaling the technology to smaller and smaller area sizes,” reducing costs and increasing performance, he said. Research is being done on scaling down storage devices but obstacles remain in atomic-based developments, according to Bona. But devices are being sought that are faster than today’s flash or hard disk drives. “We’re talking about 1 million instructions per second that you want to retrieve information out of a device that is non-volatile,” which means it holds onto information when turned off, Bona said. It will be great fun watching these competing nanotechnologies duke it out in computing. Or perhaps they’ll each find a niche, at least for a while. —Christine
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Background ========== The post thrombotic syndrome ---------------------------- The post thrombotic syndrome (PTS) (sometimes called \'post-phlebitic syndrome\') is a chronic condition that develops in 20--40% of patients within 1--2 years after symptomatic deep venous thrombosis (DVT). A severe form, which can include venous ulcers, affects 1/4 to 1/3 of patients with PTS \[[@B1]\]. In contrast to research gains in the areas of diagnosis, prevention and treatment of acute venous thromboembolism (VTE), PTS has been understudied and as a result, treatment options are limited. Patients with PTS experience pain, heaviness, swelling, or other symptoms in the affected limb, which are typically aggravated by standing or walking and improve with rest and recumbency. Edema, venous ectasia, hyperpigmentation, eczema, and varicose collateral veins may be apparent. In severe cases, ulceration can occur \[[@B2]\]. Since PTS is a direct consequence of DVT, its prevalence is influenced by the incidence of DVT. Despite advances in VTE prevention and treatment, the annual incidence of VTE has not decreased over time, and remains at 1.0--1.6 per 1000 persons per year, with a per-person lifetime incidence of 2--5% \[[@B3],[@B4]\]. Because of its prevalence and chronicity, PTS is expensive, both in terms of direct medical costs and indirect costs such as loss of productivity and thus it is burdensome to patients and society \[[@B5]\]. Risk factors for the development of PTS --------------------------------------- While hereditary and acquired risk factors that predispose to the development of VTE are widely known \[[@B6]\], factors that influence the development of PTS after DVT have not been well elucidated. The only clearly identified clinical risk factor for PTS is recurrent, ipsilateral DVT \[[@B7],[@B8]\]. The site (proximal vs. distal), size and occlusiveness of the initial DVT and the intensity (i.e. target INR) of long term anticoagulation for DVT do not appear to reliably predict PTS \[[@B1],[@B7]-[@B10]\]. It is not clear why some patients develop PTS while others recover from their DVT. As a result, physicians are unable to provide their DVT patients with reliable, individualized prognostic information. Potential role of inflammation, d-Dimer and thrombophilia in the post-thrombotic syndrome ----------------------------------------------------------------------------------------- While the pathophysiology of PTS is incompletely understood, it is likely that the acute thrombus itself, associated mediators of inflammation, and the process of vein recanalization in the weeks following DVT induce damage to venous valves, leading to valvular incompetence (reflux). Valvular incompetence and/or persistent venous obstruction by thrombus cause venous hypertension, which promotes capillary leakage of plasma proteins, erythrocytes and leukocytes and the development of venous ectasia and varicosities. The result is edema, tissue hypoxia, and ultimately, in some cases, skin ulceration \[[@B11]-[@B14]\]. Inflammation and thrombosis are closely interrelated \[[@B15]-[@B17]\]. It has been appreciated over the last few years that arterial atherothrombosis is, at least in part, an inflammatory disease, and that elevations in markers of inflammation, such as C-reactive protein (CRP), increase the risk of future clinical cardiovascular events \[[@B18]\]. Clinically, patients with DVT exhibit cardinal signs of inflammation such as redness, warmth, swelling, pain and fever. Several clinical studies have examined the association between levels of inflammatory markers and venous thrombosis, and found that a two- to six-fold increase in the risk of DVT associated with elevations in plasma levels of CRP, interleukin (IL)-6, IL-8, monocyte chemotactic protein (MCP)-1 or tumor necrosis factor (TNF)-alpha \[[@B19]\]. A recent paper showed that CRP is elevated in patients with acute DVT (median 37.5 mg/L) compared with controls (5.0 pg/L), and that levels decline during the first 5 days of DVT treatment. Similar trends were noted for IL-6 \[[@B20]\], leading the authors to conclude that the thrombotic process produces a systemic inflammatory response and to speculate whether the observed decrease in levels was partly caused by treatment with heparin, which is known to have anti-inflammatory properties distinct from its anticoagulant properties \[[@B21]\]. Whether levels of markers of inflammation are predictive of PTS has not previously been examined. D-dimer is a degradation product of cross-linked fibrin that reflects fibrinolysis and is an indirect marker of coagulation activation. Recent work performed by our group and by others suggests that D-dimer levels appear to be a significant predictor of first VTE \[[@B22]\] and of recurrent VTE \[[@B23]-[@B28]\], whether measured during or after anticoagulation. Independent of VTE recurrence, persistent coagulation activation, as reflected by elevated D-dimer levels, may also predict a higher risk of developing PTS after DVT \[[@B29]\]. Thrombophilia refers to an inherited or acquired predisposition to VTE. Over 10% of the general population is affected by one or more identifiable inherited thrombophilias which have been shown to underlie at least 1/3 of cases of VTE \[[@B30]\]. The most common inherited thrombophilias are the single nucleotide polymorphisms Factor V Leiden, which renders coagulation factor V resistant to the anticoagulant effects of activated protein C \[[@B31]\], and Prothrombin G20210A, which leads to elevated plasma prothrombin levels \[[@B32],[@B33]\]. Recent studies have also established that elevation of Factor VIII level is an inherited risk factor both for first and for recurrent VTE \[[@B34]-[@B36]\], independent of age, sex, Factor V Leiden, Prothrombin G20210A or markers of acute phase activation such as CRP \[[@B35],[@B37],[@B38]\]. While results of a few studies to date suggest that thrombophilia does not increase the risk of developing PTS \[[@B7],[@B8],[@B10]\], not all thrombophilias have been examined and interactions among disorders have not been studied. Further investigation of the potential link between thrombophilia and PTS is warranted. Management of PTS ----------------- PTS could be averted by primary prevention of the initial DVT with the judicious use of thromboprophylaxis \[[@B39]\], and by preventing recurrent ipsilateral DVT by prescribing adequate anticoagulation for the initial DVT \[[@B40]\]. However, at least 1/2 of all cases of DVT occur unpredictably, hence are not preventable \[[@B41],[@B42]\]. There is no definitive evidence that using thrombolysis to treat DVT reduces the incidence of PTS \[[@B43]\]. The treatment of established PTS is limited and frustrating for patients. Severe PTS can be managed with long-term use of an intermittent compression extremity pump \[[@B44],[@B45]\]. Management of venous ulcers is labor intensive and protracted, and involves compression therapy, leg elevation, topical dressings, and sometimes surgery \[[@B2],[@B46]\]. Ulcers are often recalcitrant to treatment, and tend to recur \[[@B47]\]. A significant reduction in the overall burden of PTS is unlikely to be achieved by attempts to prevent the initial DVT or by treatment of established PTS. Rather, strategies that focus on preventing the development of PTS in patients with DVT are more likely to be effective and cost-effective in reducing the patient and societal impact of PTS. Elastic compression stockings for the prevention of PTS ------------------------------------------------------- Graduated elastic compression stockings (ECS) work by providing graded compression to the leg that is highest at the ankle, which assists the calf muscle pump, reduces venous hypertension and valvular reflux, and consequently reduces edema, improves tissue microcirculation, and prevents skin breakdown \[[@B48],[@B49]\]. Both knee-length and thigh-length stockings appear to have equal physiological effects, but knee-length ECS are easier to apply and are more comfortable \[[@B50]\]. The effectiveness of daily use of ECS to prevent PTS is supported by two studies \[[@B8],[@B51]\] but challenged by another \[[@B52]\]. All three studies have limitations that could affect their validity and generalizability. The first trial, Brandjes\' study of 194 patients with symptomatic proximal DVT, provides evidence supporting the effectiveness of ECS. Patients were randomized to daily use of custom-made, knee-length ECS applied within 2--3 weeks of diagnosis for at least 2 years (class II compression, i.e. 30--40 mm Hg pressure at the ankle), or no stocking. Use of ECS resulted in a 50% reduction in the incidence of PTS, diagnosed using a modification of Villalta\'s clinical PTS scale \[[@B53]\], or an absolute decrease from 47% to 20% of mild/moderate PTS and from 23% to 11% of severe PTS \[[@B51]\]. In contrast, a randomized trial conducted by Ginsberg suggested that ECS were not of benefit in preventing PTS \[[@B52]\]. A strength of Ginsberg\'s study was the use of a control comparison group that wore sham stockings (i.e. stockings that were 1--2 sizes too big to be effective). However, because of the small number of patients with PTS, benefit or harm of up to 30% could not be definitively excluded. Recently, Prandoni published the results of a trial performed at a single center in Italy to evaluate the effectiveness of ECS to prevent PTS \[[@B8]\]. Among 180 patients with proximal DVT, those randomized to wear daily ECS had a 50% reduction in the rate of PTS after a 2 year period, compared with controls. This study, like Brandjes\', lacked a placebo control, an important limitation due to the subjective nature of many of the components of the standardized scale that was used to diagnose PTS \[[@B54]\]. As the Prandoni study was the first, single positive study of \"off-the-rack\" elastic compression stockings, it requires replication. Also, as the study was conducted entirely at a single center in Italy, further evaluation of the generalizability of this data to North American clinical practice in a multi-center study is needed. In light of the above, we believe that a large scale, randomized placebo-controlled trial of ECS to prevent PTS is needed to provide definitive evidence of effectiveness, or lack of effectiveness, of ECS. This will allow physicians to make informed, evidence-based decisions regarding their use in DVT patients. Furthermore, such a trial will permit prospective evaluation of the predictive role of markers of inflammation, d-Dimer and thrombophilia in PTS. Methods/Design ============== The SOX Trial is a Canadian, multicenter, randomized double-blind controlled trial in patients with a first episode of proximal DVT. Aims of the study ----------------- The primary aim of the study is to evaluate whether graduated elastic compression stockings compared to inactive (placebo) stockings, worn daily for 2 years after DVT is diagnosed, decrease the incidence of PTS. Secondary aims are 1) to evaluate whether active compared with inactive stockings reduce the severity of PTS, 2) to compare mean quality of life (QoL) scores during follow-up in the active intervention vs. control groups, 3) to describe the rates of recurrent DVT, death from VTE, venous ulcers, and major bleeding during the 2-year follow-up in the active intervention vs. control groups, 4) to evaluate the cost-effectiveness of ECS for the prevention of PTS, and 5) to determine whether markers of inflammation, D-dimer and thrombophilia influence the development and severity of PTS (Bio-SOX biomarker substudy). Trial design and description of the intervention ------------------------------------------------ ### Original trial design The study was initially designed as a factorial design randomized clinical trial whose primary aims were to determine whether (1) elastic compression stockings used for 2 years compared to inactive (placebo) stockings, and (2) celecoxib, a COX-II inhibitor, used for 30 days compared to placebo, were effective in preventing PTS in patients with symptomatic proximal DVT. The rationale for the use of a COX-II inhibitor was to assess whether an anti-inflammatory drug used acutely could limit the extent of venous valvular damage and reduce the frequency of subsequent PTS. However, in December 2004, The National Institutes of Health announced suspension of the use of celecoxib for all participants in a large colorectal cancer prevention clinical trial conducted by the National Cancer Institute, because analysis by an independent Data Safety and Monitoring Board (DSMB) showed a 2.5-fold increased risk of major fatal and non-fatal cardiovascular events for participants taking the drug compared to those on a placebo. As a result of this announcement, the SOX Trial Steering Committee decided on December 21, 2004 to discontinue the Celecoxib intervention of the SOX Trial \[[@B55]\]. This decision was made after independent meetings of the Steering Committee and the SOX Trial DSMB and was based on patient safety and also on study feasibility. The SOX Trial thus resumed in February 2005 as a parallel group randomized trial, i.e. without the celecoxib/placebo intervention. ### Current trial design The study is a randomized, allocation concealed, double-blind multicenter clinical trial with an intervention allocation ratio of 1:1 (figure [1](#F1){ref-type="fig"} summarizes the study design). Once a patient is deemed eligible and consents to the study, the research nurse at each site logs onto a web-based interface which allocates the patient to one of 2 treatment groups: active stockings or inactive (placebo) stockings. Treatment group is assigned randomly using permuted blocks of randomly varying sizes at each study site to maintain close balance of the numbers in each treatment group, at any time during the trial, and to ensure allocation concealment. The active stockings intervention consists of knee-length, 30--40 mm Hg (Class II), graduated ECS worn on the DVT-affected leg daily, applied upon waking and removed upon retiring, beginning as early as possible within 14 days after DVT diagnosis and continued for 2 years. The inactive stockings intervention (the control intervention) consists of knee-length, inactive stocking (5 mm Hg compression at ankle; similar to store bought trouser sock), identical in appearance to the active stockings, worn on the DVT-affected leg daily, applied upon waking and removed upon retiring, beginning as early as possible within 14 days weeks after DVT diagnosis, and continued for 2 years. Active and inactive stockings are manufactured by SIGVARIS Corp. ![Study architecture-Flow diagram: The SOX Trial.](1471-2261-7-21-1){#F1} ### Patient eligibility criteria Patients presenting with a first, symptomatic, objectively confirmed proximal DVT diagnosed within the last 10 days (with or without concurrent distal DVT or pulmonary embolism), who have no contraindications to standard anticoagulant therapy and who provide informed consent are eligible for the study. Patients are excluded if they 1) have a contraindication to compression stockings e.g. previously documented moderate to severe peripheral arterial disease of the lower extremities, absence of palpable pedal pulses or arterial compromise due to massive venous obstruction; 2) have a limited lifespan (estimated \< 6 months); 3) have geographic inaccessibility preventing their return for follow-up visits; 4) demonstrate inability to apply stockings daily (e.g. severe arthritis, arm paralysis, and unavailability of a caregiver to apply stockings daily); or 5) were prescribed lytic therapy to treat their acute DVT. ### Study procedures Once the patient is recruited and randomized via the SOX Trial\'s web-based interface, the computer generates a unique treatment code for each patient, according to treatment group and center. The study nurse faxes the patient\'s leg measurements to the stocking supplier, who then ships the assigned pair of ECS to the patient (i.e. correct size, according to patient\'s measurements; active or inactive stocking, according to patient\'s treatment code). ECS are pre-packaged by the manufacturer in a plain box, labeled with the unique stocking code (i.e. patient and health personnel blinded). The same procedure is used to replace the patient\'s ECS every 6 months during the trial. Several strategies are used to protect against bias, including: randomization with allocation concealment, enrolling consecutive patients, blinding subjects to treatment assignment, blinding investigators, study nurses and outcome assessors (e.g. vascular technicians, radiologists) to treatment assignment, strict inclusion and exclusion criteria, and use of validated measures to diagnose PTS, recurrent VTE and to measure QoL. To prevent unblinding of study nurses, patients are instructed not to wear ECS on the day of their study visits. While it is possible that patients may be able to distinguish active from inactive ECS, this is minimized by (1) using inactive ECS, developed by the manufacturer, that appear identical to active ECS, and (2) recruiting patients with a first DVT, i.e. likely to be \"ECS-naïve\". In addition to such pre-trial design features, we will assess the blinding procedures by asking patients, investigators and research nurses at the end of the trial (i.e. at 2 years or at time of study termination) if they were aware of the treatment assignment. Study patients are followed for 2 years after enrollment. The procedures at each visit are shown in Table [1](#T1){ref-type="table"}. At any time during the study, if a patient has symptoms or signs suggestive of recurrent VTE, he contacts the study team for medical assessment, at which time recurrent VTE will be ruled in or ruled out. Similarly, if an adverse event occurs, the patient contacts the study team for evaluation. If a patient withdraws from the study, a Study Termination form is completed to account for withdrawal, which will document the reason(s) for withdrawal. If a patient dies, a Death Form is completed which documents the cause(s) of death, further classified as VTE likely or unlikely. Throughout study follow-up, co-interventions are recorded (e.g. diuretics, analgesics, exercise). While not encouraged, any temporary use of elastic bandages/wraps or active stockings during the acute phase of DVT is systematically tracked. ###### Details of study visits and telephone calls -------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ***Enrollment visit*** • The nurse completes the baseline form (inclusion/exclusion criteria, demographic and clinical variables, results of objective tests for DVT), PTS scale and pain scale • The patient self-completes the QOL form • The nurse performs the leg measurements to size the stockings • The nurse teaches patients how to apply (using a plastic leg model) and care for stockings (handling, washing), and reinforces the importance of daily use • Study stockings are supplied to the patient (within a few days after enrollment) • A venous blood sample is taken for markers of inflammation **2-week telephone call** • The nurse reinforces the importance of wearing stockings daily • Bleeding/Other Adverse Event form and pain scale are completed For the following visits, the patient does not wear study stocking to prevent unblinding of study nurse: **1-month visit** • The nurse completes the follow-up form (includes data on symptoms and signs of PTS, suspected recurrent VTE, compliance with stockings, pain scale) • The patient self-completes the QOL form • Bleeding/Other Serious Adverse Event form is completed • A venous blood sample is taken for markers of inflammation and genetic thrombophilia • The nurse reinforces the importance of wearing stockings daily **2-month telephone call** • Same as the 2-week telephone call **6-month visit** • The nurse completes the follow-up form • The patient self-completes the QOL form • Bleeding/Other Serious Adverse Event form is completed • Leg measurements are taken, and a new pair of stockings is supplied • A venous blood sample is taken for markers of inflammation, d-dimer and coagulation-based assays • The nurse reinforces the importance of wearing stockings daily **1-year visit** • Same as 6-month visit except no blood sampling • A venous ultrasound is performed to assess reflux **18-month visit** • Same as 6-month visit except no blood sampling **2-year visit** • The nurse completes the follow-up form • The patient self-completes the QOL form • Bleeding/Other Serious Adverse Event form is completed • The success of blinding (patient, nurse, and investigator) is assessed (or at Study Termination if earlier than 2 years). -------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Primary and secondary outcome measures -------------------------------------- The primary outcome measure is the incidence of PTS during 2 year follow up. PTS will be diagnosed at the 6 month visit or later if the patient reports pain and swelling of ≥ 1 month\'s duration that is typical in character (worse at the end of the day or with prolonged sitting or standing, and better after a night\'s rest and leg elevation), and that is present ≥ 6 months after the acute DVT \[[@B52]\]. Patients diagnosed with PTS will be considered to have reached the study endpoint. Severity of PTS will be graded according to the Villalta scale \[[@B53]\], a clinical post-thrombotic syndrome measure that rates the severity of five patient-rated symptoms and six clinician-rated clinical signs \[[@B53]\]. A Villalta score of 5--9 represents mild post-thrombotic syndrome; 10--14, moderate post-thrombotic syndrome; and \> 15 or presence of a venous ulcer, severe post-thrombotic syndrome \[[@B53]\]. Secondary outcomes measures include: • Reflux: Reflux will be assessed and quantified in a standardized fashion by venous ultrasound \[[@B52],[@B56]\]. • Recurrent VTE: Objective tests and validated algorithms will be used to diagnose recurrent DVT and PE, as described previously \[[@B57]-[@B59]\], and all events and deaths will be independently and blindly adjudicated. Death from VTE will be assessed as \'likely\' or \'unlikely\' after review of the death certificate, patient chart, autopsy report (where available) and by contacting the treating physician. • Bleeding: Clinically suspected bleeding events will be documented by recording the clinical event and results of any objective diagnostic testing performed. Bleeding will be defined as major if it is clinically overt and associated with a fall in hemoglobin of 20 g/L or a need for transfusion of ≥ 2 units of red blood cells; if it was intracranial or retroperitoneal; or if it warranted the permanent discontinuation of anticoagulation. Less severe clinically overt bleeding which is considered abnormal will be classified as minor. • Markers of inflammation: C-reactive protein will be assayed using a nephelometric assay. IL-6, IL-8 and MCP-1 will be measured using commercial ELISA kits which include plasma controls (Biosource Europe SA, Nivelles, Belgium). At the time of blood draw for markers of inflammation, data will be recorded on time of day, type and duration of heparin use, concomitant medications and medical conditions. • DNA polymorphisms associated with thrombophilia: QIAGEN kits and standard protocols will be used to extract DNA from peripheral blood leukocytes. Samples will be run on the ABI Prism 3100 Genetic Analyzer to analyze Factor V Leiden, Prothrombin G20210A, PAI-1 4G/4G, TAFI T1053C, TFPI C536T, TFPI T33C and FXIII Val34Leu. • Coagulation and ELISA-based assays: Factor VIII assays will be performed using the PTT based Diagnostica Stago (Abbott Diagnostics Canada, Mississauga). D-dimer testing will be performed with the IL-Test Latex Agglutination method (Instrumentation Laboratory, Lexington, USA). Lupus anticoagulant testing will be performed on an ACL9000 (Instrumentation Laboratory, Lexington, USA). Standard aPTTs are performed using Alexin HS (Trinity Biotech USA, St. Louis, USA) and HemosIL APTT-SP (Instrumentation Laboratory, Lexington, USA) as a screening test. Abnormal results are followed by a 50:50 mix using Cryocheck Normal (Precision Biologic, Dartmouth, NS), followed by Platelet Neutralization Procedure. Additionally, a Dilute Russell Viper Venom test is performed using IL test LAC Screen followed by Confirm (Instrumentation Laboratory, Lexington, MA, USA). IgG and IgM antiphospholipid antibodies are tested usingapHL-HRP ELISA Kit (Louisville APL Diagnostics, Doraville, USA). • Quality of life measures: Quality of life will be measured using the SF-36 questionnaire for generic QOL \[[@B60],[@B61]\]., and the VEINES-QOL/Sym questionnaire for venous disease-specific quality of life, which our group developed and validated \[[@B62],[@B63]\] • Cost Effectiveness measures: A decision tree-based cost effectiveness analysis will be used to assess the relative cost-effectiveness of the active stockings in reducing the incidence of PTS, as compared to a strategy of inactive stockings \[[@B64],[@B65]\]. Tree structure will schematically reflect the clinical trajectory for each strategy \[[@B66]\]. Sensitivity analyses will be conducted to verify the robustness of the qualitative conclusions to variations in the data \[[@B67]\]. Sample size and power calculations ---------------------------------- We hypothesized that event rates (i.e. PTS at 2 years) will be 30% in the inactive stocking vs. 20% in the active stocking group, i.e. a risk reduction of 33%. Our baseline event rate and effect size for the stocking group were based on a systematic review of available published data \[[@B68]\]. The total sample size required to detect this difference in event rates with a two-tailed α of 0.05 and 80% power is 600 \[[@B69]\]. We increased our sample size to 800 to take into account a projected 25% loss-to-follow up by 2 years. For the biomarker analyses, our sample size provides \> 80% power to detect ORs of 0.5 or lower, or 2.0 or higher. Larger alternatives will be associated with increased power. With regard to inflammatory markers, the analysis will be largely exploratory, as this study will be among the first to provide prospective data on levels of markers of inflammation in patients with DVT and PTS. However, the study design provides power of at least 80% to detect differences on the order of 1/3 of a standard deviation or larger between initial values of inflammatory markers in the two allocation groups. Statistical analysis -------------------- An intention-to-treat analytical approach will be used for all outcomes. Descriptive statistics for baseline variables will be calculated to describe the baseline status of the treatment groups. For the primary outcome variable PTS, a logistic regression analysis initially adjusted only for center will be used to compare the incidence rates between the active vs. inactive stockings groups. In secondary analyses, other covariates that will be adjusted for are duration of anticoagulation with warfarin, recurrent ipsilateral DVT during follow-up, temporary use of active stockings, initial type and duration of heparin anticoagulation, co-morbid conditions that could lead to leg symptoms/signs and differences in pertinent baseline variables. The number needed to treat for benefit will be calculated. As an adjunct to the primary analysis, a secondary explanatory (per-protocol) analysis will be performed as well. Subgroup analyses by age, sex, level of compliance, duration of warfarin anticoagulation and recurrent VTE during study follow-up are also planned. For the secondary outcomes valvular reflux, recurrent VTE, death from VTE, venous ulcer, major bleeding, and severity of PTS, rates in the two intervention groups will be described, and between-group differences explored in similar regression procedures. For differences in mean quality of life scores between intervention groups, analysis of variance incorporating treatment and center will be used. A difference of 4--5 points between groups is considered to be clinically meaningful. Analysis of covariance with adjustment for age, sex and comorbidity will also be used to compare quality of life between groups. For the biomarker variables, univariate analysis will be used to determine the strength of association between each biomarker variable and the occurrence of PTS. For genetic markers, heterozygotes and homozygotes will be analyzed together, given the rarity of homozygotes. IgG, IgM and lupus anticoagulant results will be dichotomized as normal or abnormal. Factor VIII, D-dimer and markers of inflammation will be analyzed both as continuous data and as proportion of values exceeding the upper 90^th^percentile. For binary and nominal data, the appropriate chi-square tests will be used to examine the respective crude associations, and for continuous variables, the unpaired 2-tailed t-test. To examine adjusted associations, multiple logistic regression analyses will be performed in which the dependent variable is the presence of PTS. The independent variables to be tested are markers of thrombophilia, D-dimer, and levels of CRP, IL-6, IL-8 and MCP-1. Other variables of interest (for interaction and/or confounding) are age, sex, ethnicity, comorbid illness, allocation to active ECS, type and duration of heparin and warfarin use, type of DVT (unprovoked vs. secondary; anatomic extent of DVT), and recurrent DVT during follow-up. The analyses will aim to (1) identify the strength of the association between relevant biomarkers, other relevant explanatory variables and PTS; and (2) explore relevant interactions. Similarly, multiple linear regression will be performed in which the dependent variable is the severity of PTS, as measured by the Villalta scale. An interim analysis for efficacy will be performed when half of the subjects have completed 2 years of follow-up. The analysis plans call for a Lan-DeMets alpha spending approach with an O\'Brien Fleming boundary \[[@B70]\]. Data management --------------- All data are collected using standardized case report forms. Data is entered on-line at study sites using a customized web-based data entry tool, and data quality is maintained via use of validation checks at the time of data entry. Data will be reviewed and cleaned by the database coordinator on an on-going basis by initiating and following up on queries to the sites. Data management is being overseen by TrialStat^®^(Ottawa, Canada). Analysis of the cleaned database will be carried out at the coordinating center under the supervision of study principal investigators. Trial committees ---------------- The Steering Committee is chaired by the study principal investigator and includes the trial coordinator and all SOX Trial grant co-applicants. The Steering Committee meets regularly and on an as-needed basis to monitor trial progress, assess the need for changes in procedures, and address issues that could affect the integrity or projected timeframe of the trial. The Expert Adjudication Committee for all outcome events is comprised of two thrombosis experts who are not co-investigators or collaborators. Clinical details and diagnostic studies relating to suspected outcome events and deaths are reviewed by the committee, who are blinded to treatment assignment. The Independent Data Safety and Monitoring Committee consists of an experienced thrombosis physician, a biostatistician and an experienced clinical trialist. Episodes of symptomatic recurrent venous thromboembolism, the post-thrombotic syndrome, and death from all causes are reported to the Chair of the Committee on a quarterly basis. Ethical considerations ---------------------- Each patient is provided with written information about the trial and written informed consent is obtained prior to study inclusion. The study protocol has been approved by Health Canada and by the local Research Ethics Committees of the participating centres. Discussion ========== In this report, we describe the protocol of a multicenter randomized placebo controlled trial of elastic compression stockings for the prevention of post-thrombotic syndrome (The SOX Trial). This large, methodologically rigorous study is evaluating the effectiveness and cost-effectiveness of ECS to prevent PTS and has been designed to provide definitive data on the role of ECS in the prevention of PTS. As such, our results will impact directly on the care of patients with DVT. This will also be the first study to prospectively evaluate the predictive role of biomarkers that are reflective of putative underlying pathophysiological mechanisms in the development of clinical PTS (Bio-SOX biomarker substudy). Our findings will increase understanding of PTS and could result in the development of novel therapies aimed at candidate biomarkers. Competing interests =================== The author(s) declare that they have no competing interests. Authors\' contributions ======================= SRK wrote the initial protocol and designed this study. HS is the trial coordinator and co-authored the manuscript. All other co-authors contributed to study design and/or manuscript revisions. Pre-publication history ======================= The pre-publication history for this paper can be accessed here: <http://www.biomedcentral.com/1471-2261/7/21/prepub> Acknowledgements ================ The SOX Trial is funded by the Canadian Institutes of Health Research (MCT\# 63142) and the BioSOX Study is funded by the Heart and Stroke Foundations of Quebec and Ontario (HSFO\#5629). SIGVARIS corp. manufactures and supplies all active and placebo stockings as in-kind support. We acknowledge the contribution of the SOX Trial site coordinators and investigators, and of Ms. Tatiana Vydykhan MSc, SOX Trial Coordinator from 2003--2006. The SOX Trial investigators and centers Quebec: Susan R. Kahn (Principal Investigator) Hadia Shbaklo (SOX Trial Coordinator) Vicky Tagalakis Stan Shapiro SMBD -- Jewish General Hospital (Trial Coordinating Center) Mira Johri Université de Montréal Isabelle Chagnon Hôpital du Sacré-Coeur de Montréal Christine Demers CHA Hôpital de l\'Enfant-Jésus Sylvie Desmarais Centre Hospitalier Pierre-Boucher Jeannine Kassis Hôpital Maisonneuve-Rosemont Marie-José Miron CHUM Hôpital Notre-Dame Lucie Opatrny Jacques Genest (Biomarker analyses) Royal Victoria Hospital Susan Solymoss Montreal General Hospital St. Mary\'s Hospital Center Ontario: Jeffrey S. Ginsberg McMaster University Medical Centre HHS -- Chedoke Division Rajendar Hanmiah St. Joseph\'s Healthcare Clive Kearon Henderson General Hospital Michael J. Kovacs London Health Sciences Centre Sam Schulman HHS General Hospital Rita Selby Sunnybrook & Women\'s College Health Sciences Centre Philip S. Wells Marc A Rodger The Ottawa Hospital -- Civic Campus Erik Yeo UHN -- Toronto General Hospital British Columbia: Reginald Smith Victoria Heart Institute Foundation Manitoba: Turnly Wong St. Boniface General Hospital Nova Scotia: David Anderson QEII Health Sciences Centre
{ "pile_set_name": "PubMed Central" }
Research NICVA’s research team develops knowledge and provides a strong evidence base on issues that affect the voluntary, community and social enterprise sector. We produce reports for the benefit of sector organisations, researchers, policy makers and organisations interested in the sector. This includes research on workforce, income, volunteers and the composition of the sector Venue Information Featured Event Risk management is an important tool in ensuring the efficient and successful operation of voluntary and community organisations, regardless of their size or nature. This training offers participants a better understanding of risk management and the tools to help implement it effectively within your organisation. Cancer Focus gets its message across Social media training was delivered to a group of Reaching Out: Connecting Older People grant holders to help build their confidence using social media and give them tips and techniques as to how to use Facebook and Twitter more effectively. Dervilia Kernaghan from Cancer Focus attended this course and found it very useful. She learnt about the different social media platforms that she could use. She developed skills in how to adopt a campaign for Facebook etc. Cancer Focus have a Communication Unit who co-ordinate all activity. Since attending the course Dervilia forwards information to the Unit in more useable and accurate format, maximising the opportunity for the ROCOP program. She uses social media to promote the program and to engage with a wider audience. Dervilia in her role has to work with and liaise with health professional and using social media helps target this audience to the benefit of the project and its beneficiaries. One of the main benefits from attending the course was the informal networking with others in the same field. At the course she met with two of the BIG funded Men’s Shed co-ordinators. As a result of this she arranged to hold “Well Aware” session at the Antrim Men’s Shed. Another of the Men’s Shed co-ordinators was invited to speak at the Cancer Focus Conference focussing on men’s health. She is of the view that informal networking aspect of the ROCOP training has been really beneficial – both in terms of promoting the Well Aware sessions but also making contacts with a wider network of relevant people as Antrim’s Men’s Shed co-ordinator was then able to give Cancer Focus details of other Men’s Sheds that it would be useful to engage with.
{ "pile_set_name": "Pile-CC" }
I am in the process of getting my dad's car for free. Its a 85 monte carlo. I want to switch motors from a 4.3 v-6 to a 350. I have multiple pre 86 350 blocks and a 89' 350 with fuel injection. The fuel injeted one is in a van and still works I don't know which motor to start with and find myself short of money. what is the difference between the motors and which one can I get the most bang for the buck Pre 86 had a two peace rear main seal,perimiter bolt valve covers and the standard intake bolt pattern. Post 86 had a one peace rear main seal which fits in a big adaprter thingy,which also requires a special oil pan.Centerbolt valve covers.And altered intake bolts in the center. Another thing is the flexlate bolt pattern is differant from the pre86s and I believe the same might go for the balancer. I would use a pre 86 block and if ya have several look for one with 010 under the timing cover.Thats spossa mean high nickel. 78 got it right, However, keep in mind the 87 and up blocks that came in passenger cars had hydraulic roller cams, the truck line kept the flat tappet cams. the late 80`s blocks were a bit thin on the castings, but they`ll live just fine in a mild street application. I would use the post 86 with the 1 piece rear main seal, as they can go there full service limit with no leaks, the older 2 piece rear seal block usually has a leak within 50,000 miles. I'm in the process of getting my dad's '84 Grand Prix for free, and switching out the 5.0L (305) for a 350. Personally, I'd go with a pre '86 block. While you have it out I'd replace the gasket set and replace the oil pan gasket/rear main seal/timing cover seal. If you get MRG-5884 from Summit Racing it includes all the oil pan seals. I choose the pre '86 block because switching in the fuel injected motor could be more costly and harded to do than switching in a carburated motor. I'm on a strict budget, so I choose a standalone (non computer controlled) engine so I don't have to worry about compatibility (just pull the bulb on the engine warning light ). That way I can just pull the computer (engine is the only thing it controls). Hello, I think the 010 on the blocks is part of the casting number on the back of the block also, the last 3 digits. It used to just signify a fully machined main web. Some are 2 bolt some 4 i think its the same casting just machined differently. I don't know about nickel content on these blocks as far as numbers, i have never seen consistency in the same casting numbers (I use an Ames hardness tester). I have the found the hardest blocks in general, to be out of police, taxi, and 40 series and up trucks. Most of these blocks can be identified by the machinig around the lifter bores. Its hard to explain but you will see the difference if you see one. I wish i knew enough about computers or i would give you a pic. All the parts on the post 86 blocks interchange, heads, and etc. the only difference is roller cam in passenger cars, slotted center intake bolt pattern which is easily done with a drill to a older intake, reverse rotation water pump which can be interchanged with the older pump, oil dip stick on passengers side which is also no problem, external balanced flywheel / flexplate. you could put older heads on the post 86 block and never know the difference. I'm planning to install a 350 in a 91 S-15 Jimmy that currently has a 4.3 with TBI. I have a 1979 350 block. I'd like to put an Edelbrock Performer package on it. The package has a TBI intake, heads, cam and lifters. Can this package be installed on the 1979 block or should I get a 1986 or newer block? Register Now In order to be able to post messages on the Hot Rod Forum : Hotrodders Bulletin Board forums, you must first register. Please enter your desired user name (usually not your first and last name), your email address and other required details in the form below. User Name: Password Please enter a password for your user account. Note that passwords are case-sensitive. Password: Confirm Password: Email Address Please enter a valid email address for yourself. Email Address: Log-in User Name Remember Me? Password Human Verification In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.
{ "pile_set_name": "Pile-CC" }
Research We are in the process of digitizing many of our collections and have decided to make some of them available to view and download online. Please check back often as we add to the online collection of digital resources. Arthur Temple Jr.'s Speech on Unionization, October 1, 1968 On October 1, 1968, Arthur Temple, Jr. spoke to employees at the Southern Pine Lumber Company Plywood Plant as they prepared to vote on joining the International Brotherhood of Plywood Company Workers union. Employees voted 114-30 against unionization on October 3, 1968. Arthur Temple Jr.'s Speech on Unionization, October 1, 1968 Arthur Temple Jr.'s Speech on Unionization, October 1, 1968 On October 1, 1968, Arthur Temple, Jr. spoke to employees at the Southern Pine Lumber Company Plywood Plant as they prepared to vote on joining the union International Brotherhood of Plywood Company Workers. Employees voted 114-30 against unionization on October 3, 1968.
{ "pile_set_name": "Pile-CC" }
The present invention relates to a vehicle door open-limiting device in which a door can be held at any open angle. If a swinging door of a vehicle is carelessly opened nearly to a fully-open position close to another vehicle or a wall, not only the door but also the other is likely to be damaged by hitting the other. A liftgate of a vehicle is likely to hit the ceiling. To prevent such accident, a device for preventing the door from opening all the way is proposed. In JP3461986B2, a locking device for preventing a door from opening comprises a rack which moves with opening of the door; a pinion which engages with the rack; a ratchet elastically fixed to the pinion; a locking member which engages with and disengages from the ratchet for locking and unlocking respectively; and a solenoid for actuating the locking member. The locking device comprises a lot of elements such as the locking member, rack and pinion for keeping the door from opening, so that the structure is complicated and becomes larger.
{ "pile_set_name": "USPTO Backgrounds" }
In the 1970s, archaeologist Peter Bogucki was excavating a Stone Age site in the fertile plains of central Poland when he came across an assortment of odd artefacts. The people who had lived there around 7,000 years ago were among central Europe's first farmers, and they had left behind fragments of pottery dotted with tiny holes. It looked as though the coarse red clay had been baked while pierced with pieces of straw. Looking back through the archaeological literature, Bogucki found other examples of ancient perforated pottery. “They were so unusual — people would almost always include them in publications,” says Bogucki, now at Princeton University in New Jersey. He had seen something similar at a friend's house that was used for straining cheese, so he speculated that the pottery might be connected with cheese-making. But he had no way to test his idea. The mystery potsherds sat in storage until 2011, when Mélanie Roffet-Salque pulled them out and analysed fatty residues preserved in the clay. Roffet-Salque, a geochemist at the University of Bristol, UK, found signatures of abundant milk fats — evidence that the early farmers had used the pottery as sieves to separate fatty milk solids from liquid whey. That makes the Polish relics the oldest known evidence of cheese-making in the world... The African Maasai tribe consume a lot of cow’s milk, often mixed with cow’s blood. I have no idea about what if any chemical interaction between the two fluids is, or if the blood breaks down lactose. The Roman legions went great distances with hard cheese, which is one of the few primitive foods, like pemmican, that travel well. If you don’t have such a food, your travel is dependent on game animals, which for a large number of people is unlikely. At least by the days of the republic, they were also big consumers of meat and grain, enough so that orders were issued that meat had to be either boiled or roasted. 16 posted on 08/02/2013 2:01:20 PM PDT by yefragetuwrabrumuy (Be Brave! Fear is just the opposite of Nar!) To anyone who hasn't read the comments to the original article (and the "Dairy Diaspora" graphic), I must quote this one from "L B": This is standard leftist propaganda that if it can't be "Out of Africa" it has to "Out of the Middle East". Nothing can evolve in (or expand out of) ancient Europe, and in fact ancient Europeans never even really existed, Europe has only ever been a "destination for immigrants". It's been proven that modern (Northern) Europeans are not primarily descended from the small number of Anatolian farmers who shifted their habitat up the Danube during the mid-Holocene Climatic Optimum. (Which incidentally, on the subject of leftist propaganda, was so much warmer than today that Denmark had a Mediterranean climate.) And the signature characteristic of adult lactase persistence in Europe is its identifiability with the blond Nordic type. The blonder you are, not the more Middle Eastern looking you are, the more likely you are to have it. So who are these blonds? Where did they come from? When did they get their hair and eye color? Where did they get those giant ultra-modern skulls and that microcephalin haplogroup D gene for larger brain size from? Where did they really spend the last glacial maximum -- are they the Iberians showing up in Morocco 30,000 years ago? When and by what routes did they re-populate the North Sea/Baltic region? How did they get down to the Ukraine for the Indo-European expansion 5000 years ago? That little bit of background context is needed, before we can ask when, where, and how did they become lactase-persistent, and how did this characteristic spread through Europe, and down to India with their chariots. A background context the Left is working full time today to erase from history -- in advance of the final erasure of its subjects as well. Thanks Renfield. "The last aurochs died in Poland in 1627" it sez here -- remarkable, considering they were the basis for domesticated cattle and that event is prehistoric -- one long haul, and they almost made it to the present. 26 posted on 08/02/2013 5:40:07 PM PDT by SunkenCiv (It's no coincidence that some "conservatives" echo the hard left.) The lactobacteria responsible for acidifying milk is naturally in the raw product. Acidified milk is not hospitable to the bad strains of bacteria that cause food born illness. Pasteurizing destroys the natural beneficial lactobacteria. Raw milk need not be innoculated... it’s just a time issue. I have opened sealed and refrigerated bottles of raw milk 3 months past it’s “expiration date”... the cream on the top is literally sour cream. The skim milk is like buttermilk. I have had a glass of milk every night before bed for my whole life. I am a 73 year old woman and when I get a bone scan every few years they always write WOW! on my chart. Years ago when my husband was in the USCoastGuard I slipped down a flight of stairs and the doctor at a military hospital thought my wrist might be broken. He sent me to x-ray. When they looked at my x-ray (no break) they said I had the whitest bones they had ever seen on an x-ray and that was after looking mostly at the bones of healthy young men. Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.
{ "pile_set_name": "Pile-CC" }
[Alternating shifts: mental fatigue in nurses]. The goal of the present study was to detect signs and symptoms of mental fatigue in nurses working in the hospital with shift schedule. The signs and symptoms of mental fatigue were measured by a subjective indicator, composed of a check list and two objective indicators called critical frequency of light fusion (Flicker) and Reaction Time to auditive stimulus (RTs). During fifteen consecutive days, morning, afternoon and night shifts of 12 nurses working in three different units of a university hospital were analyzed. The great rotation in work schedule, when in just one week a nurse can work up to three different shifts, is hazardous to the health, social, familiar and professional life of those nurses, who were not satisfied with the work schedule adopted by the institution and showed signs and symptoms of mental fatigue. The incidence of symptoms was greater for the night than for the morning shift which was greater than the afternoon shift and they frequently showed irritabilig and sleep disturbances. Indications of mental fatigue were detected by Flicker verification in the following order: morning shift greater than night shift which was greater than afternoon shift. On the other hand, using RTs the following indices of fatigue were detected: greater in the evening shift than morning shift which was greater than the afternoon shift.
{ "pile_set_name": "PubMed Abstracts" }
The far upstream chicken lysozyme enhancer at -6.1 kilobase, by interacting with NF-M, mediates lipopolysaccharide-induced expression of the chicken lysozyme gene in chicken myelomonocytic cells. Macrophages respond to lipopolysaccharide (LPS) with the activation of various genes, including the lysozyme gene. Here, we show that the level of lysozyme mRNA increases following treatment of chicken myelomonocytic HD11 cells with LPS. By transient and stable transfection of the chloramphenicol acetyltransferase (CAT) gene controlled by regulatory elements of the lysozyme gene, we identified a subfragment of the -6.1 kilobase (kb) lysozyme enhancer that mediates the LPS-induced lysozyme expression. This subfragment contains two elements (D and E), each of which matches the highly degenerate consensus sequence of binding sites for C/EBP-like transcription factors. Furthermore, we found protein complexes to interact with elements D and E whose binding activity to elements D and E is LPS-inducible in myelomonocytic HD11 cells. Immunomobility shift assays show that NF-M, a myeloid-specific C/EBP beta-related transcription factor is an essential component of these protein complexes. Mutations of the C/EBP binding sites within D and E cause a reduction of basal activity and abolish LPS responsiveness of the -6.1 kb lysozyme enhancer. These results show that the -6.1 kb lysozyme enhancer, in addition to its role in cell type-specific expression, can mediate, by interacting with NF-M, LPS-induced expression of the lysozyme gene in chicken myelomonocytic cells.
{ "pile_set_name": "PubMed Abstracts" }
Selfish Profit Incentives To Win Military Challenge In A Single Day The Guardian: The Darpa Network Challenge, which took place on Saturday, offered a cash prize for the first group to successfully locate 10 large red weather balloons hidden at a string of secret locations across the US. Competitors were asked to use the internet and social networking sites to discover the whereabouts of the balloons, in what Darpa – the Pentagon’s Defense Advanced Research Projects Agency – said was an experiment to discover how the internet could help with rapid problem solving. Effectively MIT used a pyramid scheme to drive behavior and get the desired result. This may not be a bad thing necessarily. In fact, Borderless Innovation talked about a Creative Bazar for innovation and the Indian conglomerate Tatas use karma points in somewhat similar fashion to identify and reward innovation.
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<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd"> <html><head><title></title> <meta http-equiv="Content-Type" content="text/xhtml;charset=UTF-8"/> <meta name="generator" content="Doxygen 1.8.3.1"> <link rel="stylesheet" type="text/css" href="search.css"/> <script type="text/javascript" src="pages_6c.js"></script> <script type="text/javascript" src="search.js"></script> </head> <body class="SRPage"> <div id="SRIndex"> <div class="SRStatus" id="Loading">Loading...</div> <div id="SRResults"></div> <script type="text/javascript"><!-- createResults(); --></script> <div class="SRStatus" id="Searching">Searching...</div> <div class="SRStatus" id="NoMatches">No Matches</div> <script type="text/javascript"><!-- document.getElementById("Loading").style.display="none"; document.getElementById("NoMatches").style.display="none"; var searchResults = new SearchResults("searchResults"); searchResults.Search(); --></script> </div> </body> </html>
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Am i the only one around here Who thinks each subreddit should have a "best ever" tab? 104 shares
{ "pile_set_name": "OpenWebText2" }
First Presbyterian Church (Gardner, Kansas) First Presbyterian Church (FPC) of Gardner, Kansas is a PC(USA) congregation that was established in 1866. The church now occupies its third building; the first two buildings both were destroyed, one after being hit by lightning, and another due to an electrical fire. First Presbyterian Church has a congregation of approximately 400 adult members. In addition to weekly and holiday services, the church has an active youth group, and several community outreach programs. See also List of Presbyterian churches in the United States References External links First Presbyterian Church, official website Category:Presbyterian churches in Kansas
{ "pile_set_name": "Wikipedia (en)" }
Lipid peroxidation and vitamin E in human coronary atherosclerotic lesions. We aimed to assess the oxidant/antioxidant status within the ex vivo human coronary endarterectomy samples. To achieve this, we measured products of lipid oxidation (malondialdehyde, 7-ketocholesterol), lipids (cholesterol, cholesteryl esters) and vitamin E in endarterectomy samples. Content of malondialdehyde in the plaque ranged from 0.23 to 37.36 microg/g. Unesterified cholesterol content ranged from 0.30 to 1.94 mg/g. It was 9.04+/-4.32% of total cholesterol. Total cholesterol content ranged from 1.73 to 23.69 mg/g. Cholesteryl palmitate content ranged from 0.57 to 19.10 mg/g, which is 11.43-60.86% of the total esters (mean+/-SD 40.27+/-18.42%). Cholesteryl oleate content ranged from 0.24 to 5.76 mg/g, being 9.97-21.81% of total esters (mean+/-SD 14.35+/-4.51%). Cholesteryl linoleate content ranged from 1.05 to 8.21 mg/g, being 17.84-45.15% of total esters (mean+/-SD 30.78+/-11.69%). Cholesteryl arachidonate content ranged from 0.51 to 4.20 mg/g, which is 7.56-22.87% of total esters (mean+/-SD 14.60+/-5.60%). The cholesteryl linoleate/cholesteryl oleate ratio (CL/CO) ranged from 1.01 to 4.33. Content of 7-ketocholesterol in the plaque ranged from 0.0 to 577.5 ng/g of wet weight. The 7-ketocholesterol/total cholesterol ratio was 0.003+/-0.003% (range from 0.0% to 0.008%). The 7-ketocholesterol/unesterified cholesterol ratio was 0.024+/-0.023% (range from 0.0% to 0.066%). The plaque content of vitamin E ranged from 0.0 to 40.9 microg/g of wet weight. The present study, comprising measurements of lipids, products of lipid peroxidation and vitamin E in 12 human coronary endarterectomy samples, lends the evidence for ongoing lipid peroxidation within an atherosclerotic lesion.
{ "pile_set_name": "PubMed Abstracts" }
News in Science Viper's velvet black spots key to camouflage Master of disguise Scientists have identified nanostructures in the ultra-black skin markings of an African viper that could inspire the quest to create the ultimate light-absorbing material. The West African Gaboon viper (Bitis rhinoceros), one of the largest in Africa and a master of camouflage, has dark spots in the geometrical pattern of its skin that are deep, velvety black and reflect very little light. Interwoven with white- and brown-coloured scales that are very reflective, this creates a high contrast that renders the snake difficult to spot on the richly-patterned rainforest floor. The team of German scientists from Kiel University and the University of Bonn set out to find the secret behind the black spots' ultra-darkness. To do this they compared the topography of the velvet black and pale scales. They discovered the scale surface of the black areas was made up of tightly-packed, leaf-like microstructures covered in turn with nanometre-sized ridges. One nanometre is equivalent to a billionth of a metre. "The microornamentation in velvet black regions of the Gaboon viper skin is unique among snakes," they report in the journal Scientific Reports . "Leaf-like microstructures with both nanoridges and hair-like nanoprotuberances that coincide with black skin colouration have never been described before." Master of camouflage The team theorise that the micro- and nanostructures, which protrude at slightly different angles, scatter and trap incoming light. The pale scales reflected and transmitted more light than the dark scales. Differences in reflectance between pale and black scales were higher at short wavelengths of light below 600 nanometres -- a wavelength that corresponds with blueish-green colours. This pattern of colouration provides the perfect camouflage ambushing prey in the low light at dawn and evening, or the green light in forests or blue light in clearings during the day. The researchers say the low reflecting properties of the velvet black spots also have implications for enhancing the darkness of artificial materials. "The structure-based velvet black effect could also be potentially transferred to other materials," they write. The search for a high-absorbing, low-reflecting artificial material is highly prized in science for its potential use in specialised optical systems or solar heat capture, for example. Some artificial ultra-black surfaces are already darker than the snake's spots, says study lead author Marlene Spinner of the University of Bonn's Institute of Zoology. But introducing the snake's nanotechnology could potentially enhance their light absorbancy even more. "The micro-ornamentation on the snake's velvet black scales is a further example that the same physical law applies to both nature and technology and leads consequently to similar constructions," say the researchers.
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Division bench A Division Bench is a term in judicial system in India in which a case is heard and judged by at least 2 judges. However, if the bench during the hearing of any matter feels that the matter needs to be considered by a larger bench, such a matter is referred to a larger bench. References Category:Judiciary of India
{ "pile_set_name": "Wikipedia (en)" }
["Process of the research and development received Nobel Prize in Chemistry 2002"]. Mr. K. Tanaka engaged in Shimadzu Corporation received the Nobel Prize in Chemistry 2002 for the development of soft laser desorption ionization method for mass spectrometric analyses of biological macromolecules. In this paper, the process of the research and development of desorption ionization method and the produced laser desorption ionization time of flight mass spectrometer (LDI-TOFMS) are described.
{ "pile_set_name": "PubMed Abstracts" }
Trouble logging in?If you can't remember your password or are having trouble logging in, you will have to reset your password. If you have trouble resetting your password (for example, if you lost access to the original email address), please do not start posting with a new account, as this is against the forum rules. If you create a temporary account, please contact us right away via Forum Support, and send us any information you can about your original account, such as the account name and any email address that may have been associated with it. They said that its a other Remake... For the love of god. This will be really Frustrating if the stream DIES again after one bloody hour. I will punch a baby and punt a person that for what ever reason bows down. EDIT: ITS CONFIRMED ITS A OTHER REMAKE YAAAAAY. Where the game will drag on forever to the point people cheering for bloody ward kills....AGAIN. They said that its a other Remake... For the love of god. This will be really Frustrating if the stream DIES again after one bloody hour. I will punch a baby and punt a person that for what ever reason bows down. This round will go down infamy, at least now no one will be able to whine about 1st remake screwing WE, since CLG looked ahead this time, so actually more like a best of 5 . Just to sum up some other things: ~30k+ people on the league of legends subreddit Regi is infact retiring.(xpecial mid, nhat support pls) front page of reddit in 4mins lol 1st set for today has lasted about 5 or 7 hours Lol, someone calculated that WE's support bought at least 100 wards (120 as the top estimate) in their 4th game against CLG.eu. Pretty obvious, when all she had was tier 1 boots + 2 gp10 + ruby crystal at 60 mins when opposing support finished tier 2 boots + shurelyas + locket + aegis.
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FRANCE - Muslim women face discrimination Mass transport, hospitals, post offices, these and all public services in France would be off-limits to Muslim women wearing face-covering veils if a parliamentary panel's recommendations becomes law. The panel's number two predicts such a ban by year's end. As envisaged by the 32-member multiparty panel, a woman seeking unemployment benefits or other state aid, for instance, would walk away empty-handed if she refused to uncover her face. She would also be denied entrance to the local town hall, the bus, the Metro and the university classroom. Recommendations A panoply of recommendations aimed at dissuading Muslim women from hiding their faces is contained in the report, which was drawn up after six months of hearings from experts, Muslim leaders and others. One of the other recommendations: denying resident cards and citizenship to women who wear all-encompassing veils. However, the panel was bitterly divided over recommending a ban on face-covering veils on the street, and that was not among the 15 recommendations retained after a vote.
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Jessica Kizorek used to start her day by reading e-mail and responding until she noticed she wasn't getting to the priorities on her to-do list. "Half the day had gone by and e-mail had sucked the juice out of me." • To break the habit, Kizorek, founder of BadassBusinessWoman.org, challenged herself to be more productive, cutting back to only four work hours a day. The rest she allocated to leisure. Instead of planning business meetings at Starbucks, she had phone conversations. "It's amazing when you see what you can cut out, what doesn't go directly into making you money. You only see that when you force yourself to work smarter, not longer," she says. How often do you ask yourself if you are spending your workday being productive or just being busy? Most likely, the answer is not often enough. Even as the average workweek expands, worker productivity in the United States is on a slide, a new Labor Department study shows. In the most recent quarter, the measure of employee output per hour fell at a 0.9 percent annual rate, while hours worked climbed at a 3.6 percent rate. During our workdays, we're answering e-mails, we're responding to text messages, we're chatting with co-workers, we're blogging and twittering. We're spending more than 3 billion minutes on Facebook each day. We're putting in longer hours but we're not necessarily landing more business or moving closer to our goals. "We're focusing on the urgent at the expense of the important," says Dan Markovitz, president of TimeBack Management. "People feel overwhelmed. Some is real, some is psychological. They never feel like they are caught up because they aren't getting to the important stuff." Most of us could learn a lot from the hyperefficient entrepreneur or business executive. They make lists, they set goals, they delegate, they work in blocks of time. They don't start their day in their in-box. When Carol Greenberg Brook arrives at the office, she has already read her e-mails, flagged the priorities and sent them to her assistant to print out and create a to-do list. As co-founder and president of Continental Real Estate Companies, she walks in to her Coral Gables office focused on what needs to get done. That usually includes delegating and guiding staff on how to spend their time wisely. "I'm a good communicator. I pull myself back from minutia and give direction." Experts say the biggest mistake most workers make is starting the day out reading e-mail. Instead, do the important to-dos in the first hour of work. "Ask yourself, if that's the only thing I accomplish, will I be satisfied with my day?" says Timothy Ferriss, author of The 4-Hour Workweek. He says what's most important, typically, is the task you're most uncomfortable doing — having a conversation with your boss or a challenging customer. "We need to reprogram ourselves from 'more is better' to making better decisions about how we spend our time." Ricky Arriola, CEO of Intel Direct in Miami, is among the highly productive. He runs a 700-person company and chairs Miami's Adrian Arsht Performing Arts Center. He says being in good shape and exercising give him energy to stay productive. Weekly, he writes down his goals and includes deadlines and an action plan. He knows what he must do himself, and what to delegate. "The goal is to not get caught up in things that consume my time but don't get me a whole lot of productivity. I want to focus on the big things." Arriola carefully scrutinizes whom he gives face time. "When things come up and people want my attention, I have to measure what they want with whether it will further my goal. If not, then I think before I get involved." He says this takes instilling discipline in his staff, teaching them to only request a meeting when it's something only he uniquely can handle. "Otherwise I push back." Experts say the secret to being productive is to track how you spend your day. One woman I know tracked her hours for a week to figure out why she was busy, but not making money. She discovered she was spending 10 hours a week driving to see clients. She hadn't been billing them for drive time. "It doesn't have to be a monumental analysis," Markovitz, the TimeBack Management president, says. "It doesn't even have to be consecutive days. You just need five or six days of data." The next step is asking why you are spending time on each task and getting rid of what isn't working. RescueTime is software that can track how you spend your time. One executive who used it realized that even though he was reading and responding to e-mail only a couple of minutes at a time, it was adding up to a couple of hours a day. When Stever Robbins, author of Get-It-Done Guy's 9 Steps to Work Less and Do More, scrutinized his time use, he found he was attending networking events for a group, but had never picked up a single client. Robbins says he faced up to recognizing the events as social and decided he would rather spend time hosting a dinner party. After assessing how you spend your time, you should decide how you should be allocating it, what is essential to your success or your organization's success. This often requires a talk with the boss for guidance. Once it is clear, you will want to make those tasks visible — as a Post-it on your computer screen. Clearly, the biggest challenge is avoiding distractions and staying focused. Ferriss says when people get overwhelmed, they often turn to reading e-mail as a default, instead of being proactive. He suggests sticking to set times to read e-mail. Ferriss insists the key to productivity is asking why. "Do you want more income, more time with the kids? If you are doing something and you are having fun, you're not wasting time." Tips for being more productive Identify priorities. Miami productivity expert Michelle Villalobos suggests you write down each day the one thing that would make a huge difference in your career. Do that task first. Create deadlines. Villalobos says you are more likely to stay focused if you have a set amount of time to finish a task. Manage interruptions. Figure out what or who is interrupting you. Is it instant messages? Is it your co-worker? Is if phone calls? Figure out how you can stop them. Consider using computer programs that block use of certain sites during the workday. Designate set e-mail time. Tim Ferriss, author of The 4-Hour Workweek, says people often assume their boss wants immediate response. He found most executives appreciate when workers limit e-mail use to certain times of the day to be more productive. Streamline tasks. Amy Morris, founder of Gotfamilygetorganized.com, stays productive by lumping errands together by location. She also sets a block of time for phone calls and another for paperwork. Say no. Stever Robbins, author of Get-It-Done Guy's 9 Steps to Work Less and Do More, says get rid of poor uses of time. This may require delegating, outsourcing or changing habits. Limit e-mail. Dan Markovitz gives himself three chips a day, each worth a half-hour of e-mail time. When the chips are used up, he's done with e-mail. The Tampa Metropolitan Area YMCA has named Matt Mitchell its new chief executive officer, effective Oct. 16. Selected by the Y's CEO Search Committee following a five-month search, Mitchell will succeed Tom Looby, who is retiring. Looby has served the Y Movement for 37 years, the past 10 … All of Florida's 97,000 state prison inmates are on lockdown — and will remain confined to their dorms at least through the weekend — in response to unspecified threats about possible uprisings, officials from the Florida Department of Corrections confirmed Thursday.
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165-MHz hi-fi pattern generators are compact and rack-mountable Cleveland, Ohio—Keithley Instruments, Inc., a leader in solutions for emerging measurement needs, introduces the Series 3400 Pulse/Pattern Generators. They provide key performance advantages, such as superior signal quality and precise control for pulse widths from three nanoseconds to 1000 seconds, as well as a simple, intuitive user interface. Series 3400 pulse and pattern generators are ideal for semiconductor device and material research and characterization, as well as in process integration and advanced materials research applied to such projects as nanotechnology in R&D labs and technology development labs. The Series 3400 family consists of two units – the Model 3401 Single-Channel 165 MHz Pulse/Pattern Generator and the Model 3402 Dual-Channel 165 MHz Pulse/Pattern Generator. In response to market demand, the Series 3400 represents an extension of Keithley’s pulse testing capabilities to a broad range of applications and expands Keithley's expertise beyond DC to the growing need for pulse sourcing and measurement. Pulse generators are used not only for characterization and transient analysis but also in a wide variety of applications, including data and clock simulation and functional testing for high-speed serial components. In addition, there are many specialized applications, including nanotechnology and serial communications for the wireless industry and beyond that are driven mainly by a reduction in device size and increase in operating speeds of many electronic components and materials. Keithley is evolving its capabilities to meet the changing demands these customers increasingly are facing, such as more complete testing earlier in the process and the need to avoid problems such as self-heating in smaller devices. Precision Signal Control The Series 3400 Pulse/Pattern Generators offer key performance advantages over competitive products that lead to greater signal accuracy and tighter control. The most important of these advantages is superior pulse fidelity with precision edge control, which offers the highest precision on the market. Better and more precise control of signals gives engineers greater precision when testing electrical components and characterizing new materials. The signals produced by the Series 3400 units also have less voltage overshoot, making the signals cleaner and more reliable. Signals generated by the Series 3400 also have greater amplitude accuracy and flatness and less edge-to-edge jitter. These desirable signal characteristics give designers greater pulse control for better measurement certainty. Custom Controlled Instrument Keithley's Series 3400 Pulse/Pattern Generator instruments are designed for maximum flexibility, giving users full control over the pulsed source. Users can set critical parameters, including amplitude, rise time, fall time, pulse width and duty cycle, frequency, delay, and offset -- all based on the specific needs of the application. The Series 3400 family also has pattern generation capability, which lets users simulate serial data patterns to test devices and determine their performance characteristics in less than ideal situations. The Series 3400 Pulse/Pattern Generators feature a maximum frequency of 165MHz with a minimum frequency capability down to 1 milli-hertz and pulse amplitudes of ±10V or ±20V. The minimum attainable pulse width is three nanoseconds, which is ideal for advanced research in nanotechnology materials and devices. Ease of Use Series 3400 instruments are the most intuitive pulse products on the market. Soft menu-specific buttons on the front panel reduce the total number of buttons on the unit. Competitive units have more buttons, making them harder to use. A simplified menu structure eliminates deep, confusing menus common in competitive units. Also, command menus are easier to navigate and require fewer configuration steps, which gets users up and running quickly. The more intuitive interface makes the units quicker to learn than older, more complicated interfaces. Plus, an industry standard command interface eliminates the need to rewrite existing software, reducing installation time and the costs associated with switching from a competitive unit. Series 3400 instruments easily integrate with other instruments, such as digital multimeters, source-measure units, semiconductor characterization systems, and oscilloscopes. The Series 3400 instruments include multiple user connections, such as GPIB and USB, making them easier to set up and integrate with other systems. Price and Availability: Keithley’s Series 3400 Pulse/Pattern Generators are priced at $12,500 (US) for the single-channel Model 3401 and $17,500 (US) for the dual-channel Model 3402. Availability is end of June, 2006. For More Information. For more information on Keithley's Series 3400 Pulse/Pattern Generators and to view a short online product presentation, visit http://www.keithley.com/pr/031.
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Jeryl Lynn Jeryl Lynn are strains of mumps virus used in the Mumpsvax mumps vaccine made by Merck. The strains are named after Jeryl Lynn Hilleman. In 1963, Jeryl’s father, Dr. Maurice Hilleman, was leading efforts to produce a mumps vaccine for Merck. He cultured the mumps virus from her throat, and in 1967 a vaccine was produced which is now widely used. The Jeryl Lynn strains used in the manufacture of Mumpsvax later turned out to contain two distinguishable viral substrains, JL1 and JL2. Further research showed that the JL1 strain was preferentially selected by propagation in Vero and chick embryo fibroblast (CEF) cell cultures. The JL2 strain was preferentially selected by passage in embryonated chicken eggs. In the US the Jeryl Lynn strain-based vaccines supplanted the previous, killed virus, vaccine in 1978. See also MMR vaccine References Category:Vaccines Category:Mumps
{ "pile_set_name": "Wikipedia (en)" }
A perspective on homelessness, ethics, and medical care. People who are homeless are known to have high rates of morbidity and mortality. Yet their attitudes, values, and desires regarding end-of-life care have not been studied. This article reports on the findings from interviews with groups of homeless individuals in the Twin Cities performed by University of Minnesota researchers. It explores the implications of homelessness on two commonly discussed ethical principles-autonomy and justice.
{ "pile_set_name": "PubMed Abstracts" }
Q: Null reference in a foreach over "Table.Rows" In the line foreach (DataRow Row in Table.Rows), I'm getting a NullReferenceException. The program is in an emulator in C#. When I debug it and it crashes, it highlights the word foreach in yellow. I've pasted my whole code below. using System; using System.Collections.Generic; using System.Data; using Reality.Storage; using System.Threading; namespace Reality.Game.Moderation { public static class ModerationBanManager { private static List<uint> mCharacterBlacklist; private static List<string> mRemoteAddressBlacklist; private static Thread mWorkerThread; private static object mSyncRoot; public static void Initialize(SqlDatabaseClient MySqlClient) { mCharacterBlacklist = new List<uint>(); mRemoteAddressBlacklist = new List<string>(); mSyncRoot = new object(); mWorkerThread = new Thread(new ThreadStart(ProcessThread)); mWorkerThread.Name = "ModerationBanManager"; mWorkerThread.Priority = ThreadPriority.Lowest; mWorkerThread.Start(); ReloadCache(MySqlClient); } public static void ProcessThread() { try { while (Program.Alive) { Thread.Sleep(600000); using (SqlDatabaseClient MySqlClient = SqlDatabaseManager.GetClient()) { ReloadCache(MySqlClient); } } } catch (ThreadAbortException) { } catch (ThreadInterruptedException) { } } public static void ReloadCache(SqlDatabaseClient MySqlClient) { lock (mSyncRoot) { mCharacterBlacklist.Clear(); mRemoteAddressBlacklist.Clear(); MySqlClient.SetParameter("timestamp", UnixTimestamp.GetCurrent()); DataTable Table = MySqlClient.ExecuteQueryTable("SELECT * FROM bans WHERE timestamp_expire > @timestamp"); foreach (DataRow Row in Table.Rows) { uint UserId = (uint)Row["user_id"]; string RemoteAddr = (string)Row["remote_address"]; if (UserId > 0 && !mCharacterBlacklist.Contains(UserId)) { mCharacterBlacklist.Add(UserId); } if (RemoteAddr.Length > 0 && !mRemoteAddressBlacklist.Contains(RemoteAddr)) { mRemoteAddressBlacklist.Add(RemoteAddr); } } } } public static bool IsRemoteAddressBlacklisted(string RemoteAddressString) { lock (mSyncRoot) { return mRemoteAddressBlacklist.Contains(RemoteAddressString); } } public static bool IsUserIdBlacklisted(uint UserId) { lock (mSyncRoot) { return mCharacterBlacklist.Contains(UserId); } } public static void BanUser(SqlDatabaseClient MySqlClient, uint UserId, string MessageText, uint ModeratorId) { MySqlClient.SetParameter("userid", UserId); MySqlClient.SetParameter("reason", MessageText); MySqlClient.SetParameter("timestamp", UnixTimestamp.GetCurrent()); MySqlClient.SetParameter("timestampex", UnixTimestamp.GetCurrent()); MySqlClient.SetParameter("moderator", ModeratorId); MySqlClient.ExecuteNonQuery("INSERT INTO bans (user_id,reason_text,timestamp_created,timestamp_expire,moderator_id) VALUES (@userid,@reason,@timestamp,@timestampex,@moderator)"); lock (mSyncRoot) { mCharacterBlacklist.Add(UserId); } } } } A: If it's really being thrown at this line: foreach (DataRow Row in Table.Rows) Then Table or Table.Rows is null. If it is being thrown from inside of your foreach loop: foreach (DataRow Row in Table.Rows) { //aka in here } Then it most likely means that one of your rows is null. To find which one add this at the beginning of your loop and place a break point inside of the if statement. foreach (DataRow Row in Table.Rows) { if(Row == null) { //breakpoint here! } } You can also just examine Table.Rows while debugging, but if there are 1000s of rows this is not a realistic option. A: If you have NullReferenceException in that exact line, this means that either the Table variable or the Rows property is null. There are almost no other options. Please put a breakpoint there and check which one of them is null - and then investigate and correct that.
{ "pile_set_name": "StackExchange" }
Alright. I know that one friend I'll not change his mind as it honors his grandfather who he's named for and is close to. DH is pretty stuck on James. But yeah, with all the hypotheticals it could end up totally different. It depends on how you and your friends feel more than anything else. For example, I adored the name Oliver for years. One day a girl from high school (not even a friend of mine - and we live hours away from each other) named her son Oliver. The appeal of the name was shattered. Make sure none of your friends would feel the same way if you were to use the name James.
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The Most Powerful Sales Tool at Lowe's: Satellites - 1337biz http://www.businessweek.com/articles/2014-02-26/lowes-most-powerful-sales-tool-satellites ====== maxerickson The actual information is less exciting: _Laura Champine - Canaccord Good morning. Thanks for taking my question. Your close rate performance was impressive, how do you measure that? Bob Hull - Chief Financial Officer Laura, so a couple of different ways, so of late, we have been using satellite imagery. So we take pictures of parking lots throughout the course of the year. We max that up with actual transaction counts in stores. Of late we have been actually using some technology that involves traffic counters in the stores, which gives us close rate by day, by hour, which is going to further allow Rick and the team to optimize labor going forward. We have tested both methodologies for the same stores and got similar results. We are pretty comfortable with the methodology. It allows us to forecast and see actual improvement in close rates_ From the earnings call: [http://seekingalpha.com/article/2051323-lowes-companies- ceo-...](http://seekingalpha.com/article/2051323-lowes-companies-ceo- discusses-q4-2013-results-earnings-call-transcript?page=7&p=qanda&l=last) ------ gadders >> "A little creepy? Yeah. Smart? Definitely." Is it creepy? They're only looking at car park occupancy in aggregate. They're not tracking car number plates. ~~~ protomyth I don't get the creepy either. It seems like an ok plan to judge volume[1] of traffic compared to sales. Might even do some analysis of what vehicle types are going to the store. 1) I am with other posters and would have put up security cameras and done my count that way ------ dmd I'm puzzled why they would go to the expense of using real time satellite imagery for this, versus mounting a camera on a light pole in the parking lot. ~~~ kfcm This is the exact same thought I had when reading the story. Not only would it be cheaper, but you could follow each vehicle through the lot and figure out the traffic flow patterns better. Plus, to tie in with this other front-page story ( [https://news.ycombinator.com/item?id=7346629](https://news.ycombinator.com/item?id=7346629) ), you could track the plates of the cars, and tie that in with retail cellular tracking ( [https://news.ycombinator.com/item?id=5154089](https://news.ycombinator.com/item?id=5154089) ). Facial recognition still needs a couple of years. Over time, you could tie the cellular phone, vehicle, and electronic payment (debit or credit card) to an individual. Continual tracking. And all brought to you by technology. In the words of Pogo: "We have met the enemy...and he is us." ~~~ k2enemy That, and you can see the parking lot on cloudy days too. ------ joebo Why not track how many times the entrance/exit doors open or close? Or add a laser(?) that cuts across the entrance that counts each time it's line is broken. Directional but also simple to do. ~~~ Naga A lot of companies do this actually. Sure its not perfect, but it gives a good enough estimate. ------ rollthehard6 It doesn't sound like it would make sense to do this given that stores generally have counters on the readers that detect stolen tagged items on exit. Surely it would be easier to use this data to figure out when the busy periods fall? ------ mrfusion How about if a hardware chain used satellite imagery to detect new structures being built, like sheds, barns, etc, and mailed targeted coupons out to the property owners? ~~~ TheCraiggers Isn't that a bit late in many respects though? The holy grail for a hardware company would be knowing when a person was _thinking_ about building a new shed, barn, etc, not when they've already bought all the wood and nails to begin construction. That said, we already know they're trying their damnedest to track just that. ~~~ vailripper Isn't permitting info in the public domain? I wonder why they don't leverage that? ~~~ TheCraiggers A good question. My assumption is that even though it's considered public knowledge, there is still a cost for it and it's not electronic. For instance, in my state and/or township one can go to township office and request a copy of all the property taxes for any piece of land, no matter who owns it. It costs something like ten dollars and in return you get a hardcopy with a bunch of numbers on it. Assuming the process for getting copies of new permits is similar, the biggest downside is cost for the information and paying for some intern or whatever to type it in. Even if it's five dollars plus intern is decent chunk of money (I have no idea what the profit margin is on lumber, etc). And then you have to factor in the cost of the promotion which will eat into yet more profits. ~~~ drone In Houston, it's electronic and searchable. See: [http://www.cohtora.houstontx.gov/ibi_apps/WFServlet?IBIF_ex=...](http://www.cohtora.houstontx.gov/ibi_apps/WFServlet?IBIF_ex=online_permit_start) ------ incision Neat. Satellite imagery isn't terribly expensive and Lowes has 1830 stores. I'd bet it's a lot more efficient in the end to just buy a consistent set of images for X stores of interest, X times a year than worry about the installation, maintenance of location specific concerns of cameras/sensors at every store. ------ mkmk Kroger uses infrared near the checkout lines to similar effect: [http://www.timesdispatch.com/business/retail/infrared- techno...](http://www.timesdispatch.com/business/retail/infrared-technology- cuts-kroger-checkout-time/) ------ squigs25 really cool? yes. Impractical? probably? Scanning earth using satellites is really cool. Maybe they're outsourcing this to a central company, and paying a hundred bucks per store per month. fine. But to be honest, there are some more effective low tech ways to catch these numbers, for example by looking at the number of transactions, or installing sensors on every entrance to count the number of people entering. Seems like they're shooting a pigeon with a cannon. ~~~ kej >But to be honest, there are some more effective low tech ways to catch these numbers Heck, just have someone count cars and write down the time whenever they retrieve shopping carts from the parking lot. ------ suprgeek "Satellite imagery" is the most powerful Sales Tool? I understand the need for "link-baity" headlines but this is flat-out wrong. The very same article goes on to state some numbers - 1% improvement vs 2% reduced labor. If they can attribute it ALL to Satellite Tracking as opposed to say other promotions/general economy & barring other accounting tricks, it is still too little to be even attributable. ~~~ lostlogin At the hospital I work at we correlate 'sales'in a similar way. Just we found a cheaper way. We noticed that at night less people come in. So we reduced staffing at night. ------ gstar I don't understand why they don't correlate EPOS, door and aisle counters, put it in their data warehouse, and have precise close rate based on 1) visits 2) store departments I'd have thought this was totally standard practice! Still though, really cool that they have confidence that satellite imagery is a good proxy for this. ------ rickdale Hm, what the article doesn't say is that Lowes are typically located near Home Depot. Definitely close enough to get a snapshot of competitors parking lot too.
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IT'S SATURDAY, SEPT. 8, in Tyler, Texas, and it is officially "Jimmy Butler Day." The chancellor of Tyler Junior College has just bestowed an honorary degree on its most famous alumnus, followed by the city council handing the key to the city to the Sixers swingman, an honor not even bestowed upon native son Earl Campbell, an NFL Hall of Famer. Later in the day, a beaming Butler, wearing diamond hoop earrings and torn jeans, looks on as the lobby of the school's gym is renamed in his honor, his jersey is retired and he is inducted into the school's Circle of Honor, making him the youngest graduate to receive that distinction. During the Jimmy Butler Day ceremonies, Butler gives what longtime Tyler basketball coach Mike Marquis says are two of the most thoughtful and impassioned speeches he's ever heard, describing for students how, as a quiet teenager, he was able to springboard from Tyler to Marquette to NBA stardom. "For me, when you're talking about basketball and where you come from, there's always going to be a lot of emotions," Butler says later. "That s--- is special." Later that day, while coaching in the alumni charity game, a scowling Butler paces in front of the bench, yelling out defensive assignments and pick-and-roll instructions. Marquis considers asking Butler to chill a little, then thinks better of it. It's Jimmy Butler Day, after all. And like it or not, that red-line approach to all things hoops is a big part of who Butler is -- and why Sept. 8, 2018, is Jimmy Butler Day in the first place. Almost seven months later, while reminiscing about the day's events and an honor long since overshadowed by his tumultuous and perhaps career-defining NBA season, Butler says: "It's crazy to think that was just [seven] months ago. ... It legit seems like it could have been two years ago." Good Jimmy is an All-NBA player on a championship team. Bad Jimmy can derail a franchise. The Sixers are three months away from making a nine-figure decision on their 29-year-old wing. Hannah Foslien/Getty Images TWO WEEKS AFTER leaving Texas, there's another Jimmy Butler Day -- of sorts. In 2017-18, with Butler averaging a team-high 22.2 points and 36.7 minutes per game, the Minnesota Timberwolves won 47 games and made the playoffs for the first time in 14 years. And then, in a pattern that has come to define his NBA career -- and now, the Sixers' playoff chances -- "Good Jimmy," the aw-shucks, hard-working, small-town Texas kid, eventually gave way to "Bad Jimmy," the moody, aloof, combative and uncompromising diva with delusions of grandeur. In July, Butler turned down a four-year, $100 million extension from the Wolves. Then, at the start of camp, upon surveying the state of the franchise, he announced to his longtime friend and mentor, and now former Minnesota coach, Tom Thibodeau, "This s--- ain't it," and demanded a trade. And then, on Jimmy Butler Day 2, he punctuated the ultimatum by summarily losing it in his first practice since the trade demand, in which he proceeded to challenge the manhood of young stars Andrew Wiggins and Karl Anthony-Towns -- and everyone else in the organization except Crunch, the mascot. "Jimmy's approach has always been not whether he's right or wrong. It's about, 'Are you giving everything you have?'" Marquis says. "And some people don't like to be challenged like that. Society is changing. The old days of coach Bobby Knight and Gen. George Patton being a fiery motivator are not what today is acceptable. Jimmy's got some real old-school toughness in him. And guys don't like to be questioned about their effort." But the expletive-laced tantrum worked. A month later, Butler was traded to Philadelphia. If the past few years have taught us anything, it's this: Butler's All-NBA, two-way greatness and his volatility make him one of the most compelling figures in this year's NBA playoffs. The league waits, popcorn at the ready, to see which Jimmy will show up for the Sixers, both for the next couple of weeks (or months) and into the summer, when Butler will be among the NBA's highest-profile free agents. "I'll be here in Philly for a little bit, and this will be the next chapter," Butler says. "We have the opportunity to do something special. We know what we can do. We talk about it every single day with the coaches in practice and when we watch ourselves on film. We know what we can do. We know. It's all about going out there now and supposedly showing the world, even though I highly doubt anyone on this team gives a damn what the world thinks anyway." Butler, who tweaked his back in his return to Minnesota, has led the NBA in minutes per game since 2013-14, the year he became a starter. Hannah Foslien/Getty Images BUTLER'S IGNOMINIOUS RETURN to a cold and gray-skied Minneapolis begins with him getting booed at breakfast. The friendly-fire heckling from his Sixers teammates, meant to lighten the mood and prepare Butler for the real thing inside Target Center that night, continues through his routine Pilates session and the Sixers' shootaround at North Central University near downtown. "Amir [Johnson] has been booing me since we woke up this morning," Butler says after the shootaround while reclining in the bleachers, his legs extended and his elbows out. Three hours before tipoff, after finishing his pregame routine inside a mostly empty Target Center, he sits courtside, striking the same relaxed pose. It's the forced body language of a villain who's eager for the world to know: I'm enjoying this. That was an attitude Butler tried awfully hard to convey during his late-March return to Minnesota and his return the next week to Chicago, where he spent his first six NBA seasons. The emotional, late-season road trip to face the franchises Butler elevated and then incinerated served as a pre-playoff barometer of Butler's emotional state, his connection to his new teammates and, thus, the Sixers' playoff fate. "Whether I'm home in Texas or in Chicago or Minnesota or Milwaukee, each place played a part, a major role, in me being the player and the person I am today," Butler says. "And I'm for real grateful for all of it." Moments later, the Sixers tweet a picture of Butler's special Jordans, inscribed with the motto: You either die a hero or live long enough to see yourself become the villain. Later, when he is greeted by a thunderous round of boos and Carly Simon's "You're So Vain" during pregame introductions, Bad Jimmy smiles and shuffles onto the court like a prizefighter. In private, though, there's that other Jimmy: After finishing his warm-up, before he took the court, Butler camped out in front of the Wolves' locker room, looking like a lost kid or a politician -- bouncing on the balls of his feet, hands clasped together -- waiting to greet his former teammates and coaches with a series of slightly awkward, conciliatory hugs. "I'll be here in Philly for a little bit, and this will be the next chapter. We have the opportunity to do something special." It was classic Jimmy, a study in contrasts. As much as we want (or need, really) to define our elite athletes in oversimplified terms and roles -- good or bad, winner or loser, hero or villain -- the truth is they're just like the rest of us. Not all good and not all bad, but a combination of both on any given day. Butler's polarities, and his unwillingness to filter or hide them, are just far more pronounced than for the rest of us. In Minnesota, this left him seemingly oblivious to the wreckage he had wrought with the Wolves, who finished the season 12 games out of the eighth playoff spot and, since the All-Star break, ranked dead last in defense. "Being loved all the time, it's no fun that way," Butler says before the tip. "People will pay way more attention whenever they dislike you or hate you. Everything that you do they pay attention to because they have to nitpick something. I welcome it. I embrace it. Let's see what y'all can point out tonight." Turns out, it's quite a bit. Like his personality, Butler's performance on the court in Minnesota vacillates wildly from moment to moment. He struggles on offense, to put it mildly, passing up open corner 3s and failing to generate any significant chances on his own. But rather than lashing out in frustration or losing interest, as Butler can do, he ratchets up his game elsewhere. With the Sixers' best player, Joel Embiid, back in Philadelphia nursing a sore left knee, Butler takes over with 7 offensive rebounds, 5 assists and 2 steals -- the kind of dynamic performance on an otherwise off night that you'd expect to see from someone looking to land a max contract in the offseason. Butler finishes with 12 points on 4-of-17 shooting. "Jimmy thrives under blankets of controversy and heat-of-the-battle type moments, and I greatly respect it," Philly coach Brett Brown says. "If you look at high-level competitors, it's part of their DNA, and it's certainly part of his DNA." In search of a max contract this offseason and hoping to convince cash-rich teams such as the Lakers and Knicks that they could handle the unpredictable, supernatural force that is a fully vested Jimmy Butler, his Bad Jimmy alter ego was on its best behavior during the Sixers' last extended regular-season road trip. With a roster as good as Philly's, Butler is not required to be the face of the franchise (like he was in Chicago) or a mentor and motivator (like he was in Minnesota). "Jimmy does seem to be having fun playing again," Marquis says. "The Sixers are fun to watch, and he seems to be happy. I know him well enough to know that there are bigger and better things ahead still for Jimmy." Give Philly GM Elton Brand credit. He might have finally stumbled on a management formula that works with Butler: a $190 million carrot. Brand also has an escape clause, having made it clear that his expectations for this roster are nothing less than the Eastern Conference finals. Brown, Philly's coach, has smartly channeled Butler's intensity, and his need to have the ball in his hands, into the job of Sixers closer. "Whatever they need me to do, close games, guard people, I'm all for it," Butler says. Still, there are times when Brown sounds a bit like a hostage negotiator, communicating to Butler through the media, keenly aware of a ticking time bomb on his roster. "Right from the get-go, Jimmy came in trying to fit in and be a good teammate," Brown says before the game in Minneapolis. "From that starting point, you've seen the growth of him, just putting his own thumbprint all over the place." Late in the Minnesota game, it is squarely on the Wolves' windpipe. With 27 seconds left, Butler seals the win with two free throws and a self-satisfied sneer. Dejected Wolves fans boo him as they make their way out of the arena. After the game, inside the Sixers' crowded locker room, Butler, his teammates and the gathered media are all tuned in to the final moments of the Elite Eight game between Purdue and Virginia. Instead of watching the NCAA game together on the big-screen TV, the Sixers bunch up in several smaller groups to follow the game on a handful of phones and computer screens. Maybe it's nothing. But the scene looks like the millennial, NBA version of the old quip about 26 Yankees leaving a team event in 26 cabs. After Virginia seals the win, Butler signs his villain Jordans for a young fan before speaking briefly about his back -- "It's injured," he says -- and the reception in Minneapolis: "Not too bad, to tell you the truth." Hearing this, Amir Johnson, standing in the far corner of the room, offers one last chorus of boos. Butler smiles. Today, on Jimmy Butler Day No. 3, he's in on the joke. Perhaps no relationship is more important to the Sixers' 2019 hopes than the one between their franchise star, Joel Embiid, and Butler, whom the Sixers acquired to elevate the team into title contention. Nicole Sweet/USA TODAY Sports EARLY ON A SATURDAY morning in early April, the gym at Roosevelt University, located just a block from Chicago's Grant Park, is a beehive of activity. As the school's golf and softball teams file out of the building in their forest-green uniforms, weaving through a sidewalk crowded with tourists and toward buses waiting on Wabash Avenue, the Sixers slip in, almost unnoticed, and begin to prepare for their morning shootaround. Dressed in a funky, tie-dyed sweat suit, Butler stands off to the side, still nursing his bad back. With the Sixers nearing the end of their trip, the TV inside the Roosevelt student-athlete lounge is playing "The Blues Brothers" on a loop -- just in case the road-weary team needs a reminder of which city it's now in. In 2011, the Chicago Bulls drafted Butler out of Marquette with the last pick in the first round. The oft-told story of Butler's path -- from homeless teen in tiny Tomball, Texas, to a three-time All-Star in Chicago -- is so remarkable that it bears repeating here, even for the umpteenth time. Butler says his mother came to him one day when he was 13 and said, "I don't like the look of you ... you gotta go." Butler spent the next few years couch-surfing with friends and relatives until a local family took him in and guided the quiet and damaged soul to Marquis at Tyler Junior College. "So many guys are ultra-talents, but they haven't had to fight through the kind of adversity Jimmy has," Marquis says. "He has so much fight in him, and he takes criticism for that, but you have to walk a mile in his shoes to really understand Jimmy. Where a lot of people, when they bump into failure, would rather complain or call home or get on the Xbox or go back to their dorm and pout, Jimmy was the opposite: He went right back to the gym and went back to work." During Butler's first six seasons in Chicago, that work ethic, along with his quiet, intense drive and his rare two-way skills, willed the Bulls back into the playoffs, and it appeared that Butler had finally found a permanent home in Chicago. But before the 2014-15 season, when the Bulls offered him a four-year deal worth more than $40 million, Butler balked. Something didn't feel right. He had always thrived by gambling on himself, he explained at the time. And he was right. That season, he won the NBA's Most Improved Player Award and signed a max extension worth more than $90 million, completing his transformation from last guy on the bench to face of the franchise. Something beyond his bank account and Q-rating had changed, though. The quiet kid who had spent his formative years dependent on the hospitality of strangers was now solidly in control of where he would reside and with whom he would play. Butler was never going to give anyone, let alone an NBA team, the power to say to him again, "We don't like the look of you ... you gotta go." "Jimmy thrives under blankets of controversy and heat-of-the-battle type moments, and I greatly respect it." Sixers coach Brett Brown In his final two seasons in Chicago, Butler's relationships with his teammates, his coaches and the Bulls' front office got so bad that at one point he was dressing in a different room at the United Center. "I guess being called the face of an organization isn't as good as I thought," Butler told the Chicago Sun-Times in 2017. "You know what I learned? Face of the team, eventually you're going to see the back of his head as he's leaving town, so no thanks." When it came time for the Bulls to rebuild, they decided to do it without Butler, shipping him to Minnesota after the 2017 season. On Butler's way out of town, his trainer, Travelle Gaines, torched the Bulls on social media, claiming that they had the worst culture in the league and that he had "met drug dealers with better morals than their GM." RETURNING TO CHICAGO in the final week of the 2018-19 regular season, Butler seems to be a changed man, poised to finally make a run deep into the playoffs while playing with his third team in as many years. "This week was special for me," Butler says of his various homecomings. "I appreciate being able to play the game I love, and seeing all these familiar faces from every step of the way was special. We just have to go out there and play and do what we are capable of doing." Back at the Sixers' shootaround at Roosevelt, watching 7-foot Embiid sink Steph Curry-like trick 3s from inside a doorway 40 feet from the basket (with his feet stuck in a pair of red canvas loafers), Butler acknowledges the Sixers' center as "one of the most unstoppable players in the league right here." The normally gregarious Embiid responds with a barely perceptible nod. There don't seem to be any problems or issues, per se, but these two Sixers don't seem especially close, either. In fact, they interact with each other like cabinmates on the first day of summer camp: polite strangers bracing for an impending adventure -- or disaster. Later that day, inside the United Center, where the 60-loss Bulls try to distract frustrated fans before the game with nonstop cat memes broadcast on the scoreboard, Embiid eats his chicken-and-pasta dinner by himself, sitting in the hallway outside the Sixers' locker room, watching Final Four action. Fast-forward another week, and nagging injuries continue to keep Embiid off the floor, with his bothersome left knee preventing him from playing in Game 3 of the Sixers' first-round series against the Nets. As the intensity escalates throughout the series and Philly needs to find the edge it is missing, the Sixers don't just turn to Butler for help -- they seem to transform into him. Butler promised to fill any role the team needed -- and he delivers. In Game 1, he is a scorer, with a career-playoff-high 36 points. In Game 2, he takes on more of a point guard role, dishing the ball out for seven assists. When Ben Simmons withers early in the series, Butler demonstrates to his younger teammates how to embrace the role of the villain. "Oh, I'm all for physicality," he gleefully responds after increased contact and chirping from the Nets. His timing couldn't be better. In the third quarter of Game 4, Embiid knocks Nets center Jarrett Allen to the ground, going for a block. Brooklyn's Jared Dudley, who has been under Simmons' skin the entire series, takes exception, ramming Embiid from the side. Embiid is a force in the game, ending the contest with 31 points, 16 rebounds and 6 blocks. But before he can retaliate, Butler springs into action, cross-checking Dudley into the first row of seats and sparking a melee that results in ejections and fines for Butler and Dudley -- and a 3-1 lead in the series for the Sixers. Afterward, Butler, sitting next to Embiid, speaks to the media. The two giggle and finish each other's sentences, like new bestest buddies. "I'm just here to protect my big fella," Butler says, patting Embiid on the arm. "If somebody runs up on him, I'm gonna push him again." "And I'm gonna pay the fine," Embiid interjects, "'cause he had my back." The Sixers swingman pumps his fist. It is, once again, Jimmy Butler's day. And in that moment, with Philly one win from advancing in the playoffs with newfound swagger, the brashness for which Butler has always been criticized suddenly looks a lot different. It's an outcome to Butler's season-long saga that no one envisioned. Bad Jimmy just might be really good for Philadelphia.
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"Well, I'm the boss now." "Don't worry about my people." "But you better worry about yours." "It ain't safe around here no more." "From now on, you're Giovanni Henriksen." "There's something fishy about that guy." "I'm the project manager for Sjusjoen Belleview." "Thomas, you must meet our new partner properly." "Oh!" " Why, hello." " We go way back." "We want to treat you to a trip to Graceland." "So at least you'll be using your suspension time on something enjoyable." "I've converted to Islam." "No." "He's gone to seed since his son ran away." "Congratulations." "We're having twins?" "Fuck me." "DOUBLE HAPPINESS" " Hi, baby." " Hi." "Listen, I'm sitting here looking at carriages, and I was wondering, do you think we should have one of those where they sit one after the other, or should we go for the wide type of carriage?" "I'm not..." "I'm not sure I follow." "Tomorrow we're going" "to shop for the baby carriage, you know." "Oh, yeah." "I wouldn't miss that for the world." "And then, I'm just wondering, because, you know, in this one thing, when the children sit one after the other," "I've read that that's good, the usual type." "Honey, I..." "But the child that sits behind..." "You know, the baby is behind?" "It can feel a bit neglected." "A little bit neglected." "So, I think this is so hard." "I can't really concentrate right now." "Can we do this tonight?" "Okay." "Then we talk about it later." "Yeah." "Love you, too." "So, where is this party by the way?" "At some cabin Thomas Aune has rented at Hafjell." "Hafjell." "That's where he's hiding out?" "Didn't you hear?" "He got a conviction for some kind of insider-deal, has to wear one of those ankle monitor things." " Are you kidding me?" " No." "He can't move more than 20 meters." "He goes straight to jail." " That sounds like our Tommy boy, all right." "Yeah." "Oh, Jesus!" "I thought it was my parole officer." "Welcome to Honolulu, guys." "False alarm!" "Good, good." "Good atmosphere in this cell of yours." "It's getting better." "14 days to go..." "What are you doing?" "That happens to be a Bérd Breivik." "Cost me 40 grand." "40,000 for an ashtray?" "Are you an idiot or something?" "That sculpture is probably worth around 80 now, so I don't know who's the idiot here." "This art thing, the value tends to appreciate pretty good, huh?" "If it's the right art." "Club's been doing better." "We could use a little investment." " Under the radar, so to speak." "Yeah." "Money laundering." "If you've heard of that." "We have to hook you up with my art dealer in Oslo." "My man, Max." "Good." "Go talk to him." "Hmm?" "But I..." "What the hell do I know about art?" "What's there to know?" "Buy stuff that costs more when you sell it." "First time in The Big Apple?" " How did you guess?" "The fanny pack's a giveaway." "Yeah, right." "So, what'd they book you for?" "Oh, no, no, no." "You see, I'm a policeman, you know, from Norway." " Oh, okay." "Yeah." "Okay." "Yeah, well, that's me." "Well, have fun." "Hello." "Thank you for taking time to see me." "It's not every day I get calls from European colleagues." " I brought donuts." "No, thanks." "I'm on a low-carb diet." "Yeah, I see." "What's this case you wanna talk about?" "A couple of months ago, a stranger shows up in my hometown." "A white, Caucasian male." "My gut says that he is kind of fishy, you know." "First I think, terrorist." "But now, mafia." "Maybe you guys have a file on him." "Nope, never seen the guy before." "I'm sorry I couldn't help you." "Well, okay." "But do you know where I can find this mafia type, where they hang out and stuff?" "If you want to do street work in our jurisdiction, your department needs to send a formal request." "Yeah." "Look, this cop from overseas just stopped by with some interesting information about our friend, the Fixer." "Oh. yeah?" "Yeah, it seems like Tagliano is maybe not so disappeared after all." "Motherfucker." "Hello?" "I was just wondering where you'd got to." "I'm sorry." "The new inventory came in, and I'm stuck here at work." "But when will you get back?" "You know how it is." "These things can take all night." "Okay." "Don't wait up, huh?" " All right?" "Okay." " I'll see you tomorrow." "Bye." "If it isn't Mr. Fanny Pack." "Looks good." "You know what?" "I'm not interested in any soliciting if that's your plan." "What?" "A girl can't ask a guy for a donut anymore?" " You want a donut?" "Okay." "Mm-hmm." "So, how did your meeting go?" " That bad, huh?" "Yeah." "You know, I have a suspect who I think is in the mafia, but the police, they won't give me any clues." " Oh, maybe I can help you." "How?" "I know a couple of places these wise guys hang out." "If you buy me dinner, I'll take you there." " I don't know." "What?" "You got any other leads?" "No." "MAIN ENTRANCE" "I haven't seen liver values like this" "I've probably been overdoing things a bit lately, yes." "But otherwise it all seems good." "That's good to hear." "Was sure that there was something seriously wrong with me." "Breathe in." "Yes." "That mole there." "Where?" " The contours are a bit diffused." "Which one?" "I think we should remove it and send it to be analyzed." "Fuck." "I knew it." "I knew something wasn't right." "Well, we do these all the time." "Better to check it out once too often rather than once too few." "So it's cancer?" "How long do I have left?" "I really think you're jumping to conclusions much too quickly." "You don't have to try to put this gently." "Some things you just know." " It's not certain that anything's wrong." "Fuck." "There's..." "There's no easy way to say this, my girl." "You're not going to take away my MasterCard?" "No, no." "Your dad has most probably been diagnosed with cancer." "I'm going to sell out of Belleview." "Carpe diem, as they say, and I want to dedicate myself to my little family." "It's just such a shame Olav isn't here." "There's a strange smell here." "Alcohol, maybe?" " Is it from you or..." "it's the new inventory." "You know, I just had a taste of it." "It's probably your condition making your nose more sensitive." "Well, it certainly is strong." "How's that pregnant yoga thing going?" "Next week it's birth exercises." "We should practice to give birth, so then you have to come." " What?" "Yeah?" "You must come with me." " Me?" "Yes." "Look, there's a limit to what a man can do and still be a man." "And I'm not crossing that line." "You're coming, I'm telling you." "Get in there." " Hi." " Hi." "How can I be of assistance?" "We're looking for a baby carriage for twins." "Well, we can sure help you with that!" "If I had to choose I'd go for this one, the TK Twinner Twist." "Yes, I've read about that one." "Yes, indeed, it wins every test, and it's very easy to fold and open again." "It's very easy to fold together and it's got very good reviews." "Well, it is rather expensive, but this is like the Rolls Royce of the range." "How much?" "It comes to about 12,000, plus tax." "12 grand?" "Yes." "We got a little misunderstanding here, my friend." "You see, we already have the babies." "We just need the carriage." "We do have simpler models." " But I like this one." "Yes?" "I really like n." " This one?" "Yes." "Don't you?" " You're not going to regret this." "Hey, I'm fine." "We just got to keep an eye on these kids being spoiled too soon, that's all." "Yeah, yeah." "Yes, but don't you think you should..." "Just..." "You have to sort of lift it over." "It's just a little tight, 'cause it's new." "No!" "Shit." "Have you broken it?" "Motherfucker." "Let me see." "Can't you be a little careful?" "Take it easy." "You broke off the whole part." "It's okay." "It's okay." "Just take it easy." "Take it easy." "12 grand." "It didn't last five minutes." "You didn't try to put it together without the folder-lever, did you?" "Look, I'll cover the repair, all right?" "Just give me a new one." "I'm sorry, that's not possible." "This was the last one." "What are you talking about?" "There's one right there." "Oh, no." "That's just a display model." "It's not for sale." "But this one is also nice." "You sell me the Rolls, and now the Volkswagen is suddenly okay?" "I'll cover the repair, that weenie-twister is coming with me!" "Hey." "No, no, no." "No, no, no." "Let go of that weenie-twister!" "Chris!" "Call security." "Give me that thing!" "Call security." "No!" "I'm warning you!" "Give me whatever you got." "What a day." "You know, maybe I'll go to that yoga class after all." "Okay." "That make you happy?" "A little." "Here's your coffee." "Oh, sorry," "I was so involved in the art." "Those are wallpaper samples." "Right." "They're very nice anyway." "So what type of art is it you are after?" "I'm after the type that's worth more when you sell it than when you buy it." "I see." "So you don't have any esthetic preferences?" "No." "The important thing is that the financing is done outside the box, sort of." "Yes, I understood that on the phone." "But don't you have a particular artist in mind?" "No inclinations?" "No, just so long as it's around 300 grand." "Three-hundred..." "Three-hundred thousand." "Okay." "Just to start somewhere, we have a Melgaard painting in at the moment." "Never heard of him." " No?" "Who is that?" "Bjarne Melgaard is one of Norway's most renowned contemporary artists." "Doesn't really ring a bell." "How's he when it comes to price and increase in value and stuff?" "The picture costs 280,000." "You can probably sell for twice that in about five years." "Perfect." "I'll take that one." "I'll buy it." "Okay?" "You don't want to see the picture?" " I'm leaving this to you professionals." "Certainly." "Just pack it up, and I'll take it with me." "Are you going out, Olympia?" " Olav?" "Hi, Dad." "Hi." "What does this mean?" "Are you home again for good now?" "I've spoken to Olympia." "She told me about your condition." "Maybe there's some meaning to this after all." "If you could just grab the back..." "Hey, boss, take a look." "I got no time." "We got an emergency with the Belleview project." "The art has arrived." "That you bought." "What is it?" "I don't know." "Looks like the monkey's getting a blowjob." "See?" "Jesus Christ, did you spend my money on a monkey getting a blowjob?" "The guy in the gallery said this was the hottest art around." "Take it back!" "I'm not sure about what kind of return policy they..." "My return policy is, get it the fuck out of here and get my money back!" "But how am I supposed to..." " Did you like working at the NAV?" "I got it, boss." " I got it boss." " Thank you." "Sit." "Where's Julius, is he coming?" "I haven't heard from him at all." "We'd better just begin." "Hi there, guys." "How's your form, Johnny-boy?" "That was a pretty wild party, eh?" "Stop dwelling on the past, jailbird." "You were so secretive on the phone, what is this about?" "Well, first I want to welcome you to this board meeting in Sjusjoen Belleview." "What board meeting?" "You left the board when i joined, remember?" "Yeah, yeah, but the way it is now," "Julius Backe had to pull out for personal reasons." "So, Julius sold his shares." "What?" "Julius can't sell without talking to us." "But relax." "It's in the best of hands." "Has Julius sold his share to you?" "An investment group comprised of local business people, with yours truly as a kind of front man." "The team up here have a slightly different vision, and they want more focus on family-friendly activities like skiing and a water park." ""Sjusjoen Belleview, El Dorado for kids."" "I got a penthouse in this thing." "I don't plan on living in Disneyland." "We happen to be the majority shareholder." "That's what makes business so exciting." "Sometimes you have to compromise." "Hello?" "Excuse me." "Hey there." "Hang it over there." "Yes?" "I've got some art here I want to get rid of." "Indeed?" "What are we talking about?" "Is it a print, photograph, painting?" "It's some kind of drawing." "Quite." "Let's see." "But this is a Melgaard." "Yeah, it's fuckin' exclusive." "This is something we'd be most interested in." "That's great." "But let's put a price down on the table, I ain't selling this to anybody for any price." "I shall get our expert on modern art to give you a valuation." "Sounds good." "Be careful." "Yes." "What the fuck are you up to with the Belleview project?" "I've had to sell out in order to deal with some family problems." "Bullshit!" "I made the deal with you!" "Not some hillbillies trying to turn the place into fucking Aqualand!" "Well, the deal is done." "I'm sorry." "Not half as sorry as you're gonna be, you whining, fucking cocksucker!" "You really wanna fuck with me?" "You can't talk like that to my father!" "Relax, Osama, it's between me and your father." "Do you have no respect?" "The man is sick!" "What's he saying?" "Come on!" "What are you saying?" "He's got cancer." "Jesus." "Why didn't you say something?" "I don't like to be a burden to people." "Fuck." "Dad, it's for you." "Then tell them that I'm out, then." "Dr. Utsi." "I'm ready." "What's the prognosis?" " Prognosis?" " Yes, how long have I got left?" "No, listen, the tests are completely fine." "What?" "I don't understand." "Is the cancer less aggressive than first assumed?" "What I'm saying is that you don't have cancer." "But what about the diffused contours?" "What about my father's medical record?" "Yes, all that was a cause of concern." "But now it's all been checked." "Jesus." "What the fuck do I do now, then?" "Look, this is good news, Julius." "Good news..." "Oh, yes." "What did he say?" "Hmm?" "What did Dr. Utsi say?" "No, he..." "What should I say..." "It's pretty much what we had expected." "We're going to do some more tests, then we'll see." "This Dr. Tutsy..." "Dr. Utsi?" " He's from Lapland." " Lapland, huh?" "He's good, huh?" " Yeah, he's good." " Well..." "If there's anything I can do, okay, don't hesitate to call." "Thank you, Johnny." "Thank you for being so generous." "All right." "About time." " Well, what's the price?" "We have a problem." "We've checked the register, and it appears that this picture was stolen last year." " What?" "Yes, so we've had to alert the authorities." "This..." "This is just stupid." "Get the painting, and I'll go to another shop." "It's not that simple." "The police are on their way to collect the painting and return it to its rightful owner." "Rightful owner?" "But I bought that from Gallery Air for several hundred thousand." "Then it's just a matter of presenting the papers." "What do you mean "papers"?" "Which papers?" "You surely must have documents relating to a purchase of this magnitude?" "Otherwise, I rather think the police will be wanting to have a word with you, too." "But of course I've got papers." "Good." " Yeah, Torgeir." " Yeah." " Talk to me." "Yeah." "The monkey picture was stolen." "They stole my monkey?" "No, it was stolen when we bought it." "Motherfucker!" "I've been talking to the people here, and the guy that sold it to us is gonna be back in a couple of hours." "So..." "You stay there, you hear me?" "I'm coming." "Sure." "Okay, boss." "You do me a favor tonight..." " Hi." "Hi, baby." "Are you ready?" " Yeah." "Yeah?" " Yeah, I was really ready." "Yeah..." " I was looking forward to this..." " Good." "Torgeir just called." "I got an emergency." "I gotta run." "The good news is Arnie's gonna take you." "Okay?" "He's taking me to yoga class?" " Yeah, he's gonna take you to yoga..." "Oh, come on." "And he's gonna buy you dinner first, okay?" "On me, okay?" "I gotta go." "You can't just leave!" "It's gonna be great." "I can't go to yoga class with Arne!" " Okay." " Excuse me?" "You the European cop who was looking for some wise guy." "Yeah, maybe." "I got a pal who runs a joint a couple of blocks from here, who can help you out." "How do you know what my friend's looking for?" "What the fuck do you care?" "Take a hike, sister." "Come on, man." "I'm getting bad vibes." "Let's get out of here." "You're not going anywhere." "Fucking Oslo prick." "You owe me money." "You con me into buying a pervo-picture and on top of that it turns out to be stolen." "Please." "I'm just a middleman." "I just got a cut!" "We need you to tell us who hired you to sell that painting." "I can't remember." "I've worked with so many..." "I'm gonna mention a name now." "Van Gogh." "You know that name?" "Vincent van Gogh." "That's the one." "You're gonna cooperate, or you're gonna look just like him." "Okay, okay, okay." "It's a guy from Lillehammer." "Thomas Aune." "That fucker." "Motherfucker." "Motherfucker." "Motherfucker!" "What's that?" "It's an installation about how society treats animals." "No, no, no, no." "What's the carriage?" "Is that a weenie-twister?" "I don't know." "I don't know." "That goes with us." "Lose the meat." "You can't just take it." "Sorry." "You don't mind if that goes with us, do you?" "Please, be my guest." "Yeah, I didn't think so." "And when a labor contraction occurs, we do doggy-breathing." "Off we go." "Dads, too." "Hey!" "First of all, what kind of a putz takes a Jacuzzi in this kind of weather?" "Get the fuck down!" "And second, where's my monkey?" "You know what?" "He called me." "He called me, the gallerist from Oslo." "And they told me it was a misunderstanding with the painting." "Oh, really?" "I promise you, I didn't plan to sell it." "But then the Belleview project come up." "And you know how that works." "So you fucked me over with the painting, so you could fuck me over with the Belleview project." "Is that about it, Tommy boy?" "No, no, no, no." "It's Max." "The idiot, Max." "He never should have sold it to you guys." "You're my friends." "But that's what happened." "Where's his monkey, bitch?" "I don't have that painting." "Don't give me that!" "I don't have it." "The gallery-people said they were gonna hand it back." "I sure don't have it." "So, I'm sorry, guys." "I think it's time for a little walk." "No!" "Guys, I go to jail." "If I go out any longer, I go to jail." "I want my monkey." "Not any further." "Johnny wants his monkey!" "Okay, okay, okay, okay, okay." "Okay, what?" "It's behind the oven in the sauna." "It's in the sauna." " That's the truth?" "Yeah." "Let him go." "No!" "Fuck it!" "Where's that piece of shit Frank Tagliano hiding, huh?" "You were dying to talk about him a little while ago, and now you fucking clam up?" "Fuck!" "Shut her up." "Easy, Jerry." "Easy there..." "You're gonna fucking pay for that, bitch." " Put the gun down!" " You fucking perv!" "Put the gun down." " Easy, easy, easy, easy." "Put the..." " Fucking perv." "Put the gun down!" "Fuck!" "Welcome to Sinatra Night here at Flamingo." "I can see that everybody's got something to drink." "That made me think of a quote that an old friend of Blue Eyes..." "Sorry, buddy, there's a dress code here tonight." "I'm gonna have to ask you to leave." "The point is this is a theme night." "And this isn't exactly the theme." "He said," ""I pity the foo!" "who doesn't drink" ""because every time they wake up in the morning," ""that's the best they ever gonna feel that day."" "Ha ha!" "This decorative sweater is worth more... ls there a problem here?" "This gorilla won't let me in." "I wonder why." "You look like Halloween." "I'm wearing traditional summer clothing." "Well, you might be the king of the Eskimos, but we have a dress code here." "I've been honored for my work as a doctor in this town, and now I'm being refused entry because I'm from Lapland." "Yeah, well, I don't really care..." "Did you say you were a doctor from Lapland?" "Yes." "By any chance, would you happen to be the doctor of Mr. Julius Backe?" "Yes, indeed." "You're all right." "Arnie, he's all right." "You're in." "Let me buy you a drink." "Now you say you are a friend of Julius." "Try that." "Is that a genuine Melgaard painting?" " You like his stuff?" " It's fantastic!" "Well, you know, for a price, it could be back on the market." "I don't have that kind of money." "Shame about Julie, huh?" "What do you mean?" "You know, I guess he didn't catch it fast enough." "His tests, they were fine." "Fine?" "The guy got the big C." "I mean, terminal, no?" "Well..." "lam bound to professional secrecy." "Son of a bitch." "I didn't say anything." "Before you go, I got a little business proposition for you." " Are you hurt?" " Yes." "Geir?" "Laila?" "Is that you, Laila?" "Geir?" "It was two guys." "Italian-American." "One short, gray hair." "The other one, younger." "Dark hair." "I can come to the station, help you do the drawing." "No, no." "You've been more than helpful." "Now go get yourself a warm beverage." "Hey, Lieutenant." "Yeah, I'm at the crime scene now." "Yeah, some hillbilly tourist who was here visiting one of the regulars, Deshawna." "Yeah, probably buying drugs." "Yeah." "As per usual, nobody's seen or heard anything." "I'm afraid this is gonna end up right in the pile of unsolved cases." "He's fucking crazy." "It's not really a good time for a call tonight, Johnny." "Well, I figured you might be gone tomorrow." " So we better talk now." "Okay." "I got a solution to the Belleview project." "You're gonna buy me out." "But I already just sold my share because of, you know what." "Yeah, you're gonna take that money you got from Tommy boy and give it to me for my piece." "But my share was four times the size of yours." "Come on, that doesn't make sense." "A lot of things don't make sense, you know." "Like your medical records for instance." "Where the fuck did you get this one?" "It's not important where I got it, Julie." "What's important is what your kids are gonna say when I show it to them." "No, no." "Come on, please." "You've got to understand, Johnny, at first I thought I was ill..." "Then Olav came home, and I was given a fresh start with my kids." "Julie, you're mixing me up with somebody who gives a fuck." "Just sign over the money." "What a fucking idiot, I..." "You really don't want your kids knowing the truth about their father, do you?" " Yeah." " We're ready for you now." "Sorry to disturb you guys." "But I ran into the doc, and he has some news that just won't wait." "Well, as we all know Julius has been diagnosed with cancer." "We've done some new tests, it seems the cancer is in the process of receding." " Receding?" "Yes." "It looks as if he is going to make a complete recovery." "This is almost like a miracle." "It must be all the care from you." "Yeah!" "I've got a boss who loves Sinatra, who's a big Sinatra fan." "And because of that, the band has prepared a tune that we thought we'd hear if..." "What do you feel, boss?" " Take the challenge?" "What?" "Me?" " Yeah." "No." "Oh, come on." " No, I can't." "No..." "Johnny." "Johnny!" "Johnny, Johnny, Johnny, Johnny!" "Johnny, Johnny, Johnny!" "All right." "All right." "Let's hear it!" "Let's hear it!" "Let's hear it!" "Let's hear it!" "How did all these people get in my room?" "Maestro, one of your finest chords, please." "Now this could only happen to a guy like me" "And only happen in a town like this" "Am I right?" "So may I say to each of you most gratefully" "As I throw each one of you a kiss" "This is my kind of town" "Lillehammer is" "My kind of town" "Lillehammer is" "My kind of people, too" "People who smile at you" "And each time i sneeze, Lillehammer is" "It must be that Lillehammer freeze" "Lillehammer is" "Majestic mountain views all around" "It's my kind of town" "Am I right or am I right, huh?" "How am I doing so far?" "Sit down." "I'm not finished yet." "My kind of town" "Lillehammer is" "My kind of town" "Lillehammer is" "Reindeer and moose, hello" "And you know, all that snow" "And each time I run" "Lillehammer is" "Busting my buns, Lillehammer is" "So, no clues as to where this guy is from?" "I'm telling you, that's where Tagliano was hiding out." "No passport, no plane ticket, no driver's license, no nothing." "Well, didn't it occur to you to just ask the guy?" "We were gonna." "But then Mr. Trigger Happy here decided to shoot him instead." "Hey, look, he attacked me." "I mean, fuck this, huh?" "Now, look at this." "Pack your lederhosen, boys." "You're going to Norway." "It's my kind of" "Town" "Yeah!" " Yeah!" " It's my kind of town, baby." " That's still the tune." "Bull's eye!" "Yeah!"
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Q: SAP UI5 embed manifest.json right I just wrote the description file for my UI5 application. Now I have these questions: Where and how can I embed the manifest.json in my project correctly? How can I test if it's working fine? (correctly embedded) Is the "start_url": "" similar to initialPage of the index.html? Many thanks for your guidance, Chris A: Usually, the manifest.json file (aka. "Application Descriptor") is put into the same folder as where the Component.js file is located. The component will look for the file name "manifest.json" in the same folder. If the descriptor is located somewhere else or has a different file name, assign the relative URL of the file to the manifestUrl in the component factory function like this, which is recommended to do so anyway because it ... loads the descriptor file before creating the component (same as manifestFirst) allowing us to preload dependencies and model data to improve the initial loading time. makes specifying the name of the component redundant. You can either pass the name of the component or the URL of the descriptor file to load [the component] via the descriptor. To see if the file is correctly embedded, run the app and see if e.g. the rootView is loaded, models (for example ResourceModel for i18n) are set to the component instance, custom resources assigned to sap.ui5/resources are loaded, etc. etc.. → Make sure to include (or in case of manifestFirst/ manifestUrl, don't be tempted to remove) manifest declaration in the component metadata. The "start_url" is purely advisory and meant for the web standard rather than for UI5. It's telling the browser where to look for the initial page when the user starts the web app. To learn more about the descriptor file, take a look at the developer guide such as "Descriptor for Applications" or as a summary, here.
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. Let d = -0.53 + k. What is d rounded to three dps? 0.008 Let j = -59 - -57.15. Let b = -1.8499768 - j. What is b rounded to five decimal places? 0.00002 Let m = 42 - 37. Suppose g + m*g = -384. Let h be ((-11)/((-66)/g))/(4/(-453750)). What is h rounded to the nearest 100000? 1200000 Let k = -42.09 - -27. Let f = -15.087108 - k. What is f rounded to 4 decimal places? 0.0029 Let g = 812698 + -368168. What is g rounded to the nearest ten thousand? 440000 Suppose -10*i + 2033 = -2447. Suppose 2*v + 2688 - i = 0. Round v to the nearest one thousand. -1000 Let y = -57650 - -46701.8. What is y rounded to the nearest 10? -10950 Let i = 2280 - 11046. Round i to the nearest 1000. -9000 Let u = -431 - 2343. Let b = u - -2774.0003698. Round b to five dps. 0.00037 Let x = -794 - -2546. Let h = x + 198. Suppose -b - h = 4*b. Round b to the nearest one hundred. -400 Let t = -962255994634 - -962255995649.999999579. Let x = 1016 - t. What is x rounded to 7 decimal places? 0.0000004 Let p = -67.171566 - -0.052566. Round p to the nearest integer. -67 Suppose -110*g + 105*g - 3*n = 234181, 2*n - 140501 = 3*g. Round g to the nearest ten thousand. -50000 Let c = 123925.050383 + -123925. Round c to two decimal places. 0.05 Let g(a) = -1353487*a - 1104. Let h be g(8). Round h to the nearest one million. -11000000 Let h = -0.80814 + 0.78414124. Let v = 170.124 + -170.1. Let d = h + v. What is d rounded to 6 decimal places? 0.000001 Let w = 12984481.39747967 + -10530028.577482. Let y = w + -2454453. Let v = y + 0.18. What is v rounded to seven dps? -0.0000023 Let m = 644.58 + -758. What is m rounded to the nearest integer? -113 Let x = -273754966 + 273754960.99999998. Let m = -2.57 - 2.43. Let a = x - m. What is a rounded to 7 decimal places? 0 Let d = 18264 - 18263.9987867. Round d to 4 dps. 0.0012 Suppose -2*l = a - 3*a + 29802, 0 = -2*l - 2. Let g = 26826 - a. Suppose 6*q + 674 = -g. Round q to the nearest one hundred. -2100 Let i = -201 + 541. Let k = 100 - i. Let g = k + 187.1. Round g to zero decimal places. -53 Suppose 34*i - 42*i = -72. Suppose 4464 + 1647 = -i*v. What is v rounded to the nearest 10? -680 Let j = -876.8 + 877.047. What is j rounded to 1 decimal place? 0.2 Let j = 10022149.39531 - 10020993.4. Let n = j + -1156. Round n to 3 decimal places. -0.005 Let a = 1.63136 - 1.683. Round a to 2 dps. -0.05 Let y = 77.44264345 + 0.55736275. Let t = 92 - 14. Let n = t - y. Round n to six decimal places. -0.000006 Let u = 600.7696 + -601. Let d = 0.1107 + u. Round d to two dps. -0.12 Let j = 18 - 26. Let s = j - -8.3. Let t = s - 0.32. What is t rounded to three decimal places? -0.02 Let m = 24.0259988159 + -24.026. What is m rounded to 7 decimal places? -0.0000012 Let s = -136558697405 - 233257342182. Let f = 369816039944.999999658 + s. Let b = -358 + f. Round b to 7 dps. -0.0000003 Let m = 571 - 563. Suppose -p + 5*j - 193825 = 0, 5*j = -p + m*j - 193815. Round p to the nearest ten thousand. -190000 Suppose -130*x + 138*x = 3119872. Suppose 5*k - 2*k - 2*a + 389992 = 0, 3*k + x = 4*a. What is k rounded to the nearest one thousand? -130000 Let h = 73.4 - 40. Let w = h - 19.5. Let f = w + -13.89999882. What is f rounded to 7 dps? 0.0000012 Let w = -64.515 + 226.398. Let v = w + -162. Let m = 1.113 - v. Round m to one decimal place. 1.2 Let k = -2055602950.6361507 - -2055603371. Let z = k + -120.3638134. Let i = 300 - z. Round i to six decimal places. -0.000036 Let m = 0 + -410. Let x = m + 410.00626. What is x rounded to 3 decimal places? 0.006 Let u = -60 + 59.755. Let d = u + 0.24912. Round d to four decimal places. 0.0041 Let l(a) = -324*a**2 - 3*a + 6. Let x be l(2). Let q = -597 - x. What is q rounded to the nearest ten? 700 Suppose 5*w = 5*g - 1948100, -4*w + 1948109 = -4*g + 9*g. Suppose 7*b + 162119 = -g. Round b to the nearest one thousand. -79000 Let b = -112.7005008 - -112.7. Round b to four dps. -0.0005 Let m = 353.9 - 359. Let o = 6.967 + m. What is o rounded to one dp? 1.9 Let o = -113.357546 + 243.357447. Let s = 288 + -418. Let c = s + o. Round c to 5 decimal places. -0.0001 Let y = -697438.9 - -697435.44000931. Let c = 3.46 + y. What is c rounded to seven dps? 0.0000093 Let n = -0.0381 + 2.7001. Round n to 1 decimal place. 2.7 Let o = -576 - -575.9653. Let r = 0.031404 + o. What is r rounded to 4 dps? -0.0033 Let x = 45132.20617 - 45132. What is x rounded to two dps? 0.21 Let r = 34.373989 + -2.275733. Let b = r + -32.1. What is b rounded to 4 decimal places? -0.0017 Suppose -2*u - 5*o = -20, 4*u + 0 = 2*o + 16. Suppose -5*t = -3*s - 10560005, -u*s + 6137922 = 2*t + 23737920. Round s to the nearest one million. -4000000 Suppose -2*d + 27 = 23. Suppose d*m + 1734 = 8*m. Suppose 3*r + 2*y + 211 = 6*r, 4*r - m = -5*y. Round r to the nearest ten. 70 Let h = -43.308 + 246.038. Round h to the nearest 10. 200 Let c = -1641343870534 + 1641343791660.8399999. Let j = c + 78872.82. Let m = -0.34 - j. Round m to 6 dps. 0 Let b = -9240 - -8506.69. Let q = b + 744.16103. Let g = q - 10.84. Round g to 3 decimal places. 0.011 Let v = -163 - -278. Let l be (15088/v)/(4119/(-4125) + 1). Round l to the nearest one thousand. 90000 Let k = -3175 + 3237.06. Let v = 63 - k. Let q = -0.9400336 + v. Round q to 6 dps. -0.000034 Let n be -4 + (-31)/(-7) - 12670485/21. Let h = -414756 - n. Round h to the nearest 10000. 190000 Let y = -40310 + 40309.959598. Round y to three decimal places. -0.04 Let z = 1296405.99354 - 1296758. Let x = 208.8 - -143.2. Let j = x + z. Round j to 3 decimal places. -0.006 Let y = -1465.17831 - 0.02169. What is y rounded to the nearest one thousand? -1000 Let h be 6/(-39) + (-836605)/65. Suppose 2*z + 57716 = 6*z. Let w = z - h. Round w to the nearest 1000. 27000 Let u(t) be the third derivative of -193*t**5/60 - 7*t**4/24 - t**3/2 - 41*t**2. Let v be u(2). Round v to the nearest 100. -800 Let a(t) = -t - 4. Let h be a(-6). Let z be (2602 - (-12)/(-3)) + h. Suppose 30*o + z = 25*o. What is o rounded to the nearest one hundred? -500 Suppose 17*n - 21*n = 108. Let o be 98/(9/(n/(-6))*-1). What is o rounded to the nearest 10? -50 Let z = 11028.0000023674 + -11028. What is z rounded to 7 decimal places? 0.0000024 Suppose -l = 3*l - 8. Let z(d) = -d - 3*d**2 + 2*d + 5*d + 5 + 9*d**l - 679*d**3. Let f be z(-5). What is f rounded to the nearest 10000? 90000 Let v = -24.6 - -17.64. Let l = v - 0.54. Round l to the nearest ten. -10 Let l = -0.10972 - 8.63628. What is l rounded to zero decimal places? -9 Let j(d) = 2*d**3 - 16*d**2 + 26*d + 32. Suppose 3*t - 3*n + 252 = 0, -4*t - n = -2*t + 153. Let a = t + 92. Let r be j(a). Round r to the nearest 100. 2100 Let j = 112757.16 - 3429822.66. Let v = -3316961.499874 - j. Let p = 104 - v. What is p rounded to five dps? -0.00013 Suppose -8*p + 5*n = -3*p - 35, 2*p - 29 = 5*n. Let w(a) = 1606*a**2 + 5*a - 14. Let s be w(p). Round s to the nearest one thousand. 6000 Let v(c) = 4943*c**2 - 75*c - 450. Let y(x) = -1648*x**2 + 25*x + 150. Let r(s) = -3*v(s) - 8*y(s). Let n be r(-10). Round n to the nearest 10000. -160000 Let u(i) = -30416*i - 312. Let h be u(43). What is h rounded to the nearest ten thousand? -1310000 Let l = -1.83706628 + 1.837. Round l to 6 decimal places. -0.000066 Let f = 1624.7 - 1624.699994379. Round f to 5 dps. 0.00001 Let r = -23154.968838 + 23155. Round r to 4 dps. 0.0312 Let d(j) = 13213*j + 2315. Let v be d(-55). Round v to the nearest ten thousand. -720000 Let l = 0.17364 - 0.17375556. Round l to 5 dps. -0.00012 Let v = -1506.5 - -1550. What is v rounded to the nearest ten? 40 Let g = -312 - -212. Let k = -178 - g. Let v = -78.00000124 - k. What is v rounded to 7 decimal places? -0.0000012 Suppose -5*o - 5*i + 46 = -i, -3*i = -2*o + 23. Suppose 0 = o*m - 12*m + 692174. Let b = m - 246087. What is b rounded to the nearest 100000? 100000 Let g = 3.010071152 + 1014.989978748. Let y = g + -1018. What is y rounded to 5 dps? 0.00005 Suppose -94*i - 586401 = -97*i. Suppose -i = -37*r + 3671033. Round r to the nearest ten thousand. 100000 Let g = 2.6082 - 3.111. Let s = g + 0.094. What is s rounded to 2 dps? -0.41 Let t = -1550 + 2340. Let w = 4661562017 + -4661562806.9999453. Let y = t + w. Round y to five dps. 0.00005 Let i = -1556.301698438 - -1556.317. Let p = 0.0153 - i. Round p
{ "pile_set_name": "DM Mathematics" }
Gait assessment with solesound instrumented footwear in spinal muscular atrophy. Gait impairment is common in spinal muscular atrophy (SMA) and is described using clinical assessments and instrumented walkways. Continuous over-ground walking has not been studied. Nine SMA participants completed the 6-minute walk test (6MWT) and 10-meter walk/run wearing instrumented footwear (SoleSound). Data were simultaneously collected using a reference system (GAITRite). The root-mean-square error (RMSE) indicated criterion validity. The decrease in walking speed represented fatigue. Foot loading patterns were evaluated using force sensors. The RMSE for stride time, length, and velocity ranged from 1.3% to 1.7%. Fatigue was 11.6 ± 9.1%, which corresponded to an average deceleration of 0.37 ± 0.28 mm/s2 . Participants spent most of their stance without heel contact. Forefoot contact occurred early in the gait cycle. These results suggest that footwear-based devices are an alternative to specialized equipment for gait assessment. Better understanding of gait disturbances should inform ongoing treatment efforts and provide a more sensitive outcome measure. Muscle Nerve 56: 230-236, 2017.
{ "pile_set_name": "PubMed Abstracts" }
The Latest: Uruguay, Venezuela advise against US travel Two Latin American governments with U.S. travel advisories have warned of the dangers of visiting the United States after two mass shootings over the weekend left more than 30 people dead. Uruguay's Foreign Ministry urged citizens who travel to the U.S. to take "extreme precautions." In a release, the ministry said U.S. authorities can't prevent the shootings because of "indiscriminate possession of firearms" and advised Uruguayans to avoid large public events including shopping centers, art and food festivals, and religious gatherings. The U.S. State Department downgraded Uruguay's travel status Friday from "normal precaution" to "increased caution" because of increased crime. Venezuela's Foreign Ministry also issued a statement suggesting that its citizens "postpone travel" to the U.S. in light of "violence and indiscriminate hate crimes." The U.S has warned its citizens against any travel to Venezuela. ___ 6:35 p.m. A list of the 22 people who died in a weekend shooting rampage at a Walmart in El Paso, Texas, shows that most of the victims had Latino surnames and included one German national. The names released by authorities Monday come two days after an attack that Justice Department officials say could warrant hate crime charges. A racist, anti-immigrant screed posted shortly before the shooting began Saturday expressed concern that an influx of Hispanics into the United States will replace aging white voters. El Paso police say 15 people remain hospitalized, including two still in critical condition. ___ 4:45 p.m. Authorities in El Paso, Texas, say the suspected gunman who opened fire at a Walmart and killed 22 people wound up at the store after driving more than 10 hours from the Dallas area. El Paso Police Chief Greg Allen said Monday that the gunman got lost in a neighborhood before ending up at Walmart "because, we understand, he was hungry." Allen didn't elaborate. The details were some of the first to come out regarding the suspected gunman's movements in El Paso prior to the shooting Saturday. Authorities have charged 21-year-old Patrick Crusius with capital murder. Crusius' hometown is the affluent Dallas suburb of Allen. The police chief said the gun used in the shooting was legally purchased near the suspect's hometown. ___ 4:25 p.m. The mayor of El Paso says President Donald Trump will visit the city Wednesday following a weekend mass shooting that killed 22 people. The White House hasn't announced the trip but the Federal Aviation Administration has advised pilots of a presidential visit that day to El Paso and Dayton, where a second weekend shooting left nine people dead. El Paso Mayor Dee Margo says he's "already getting emails and phone calls" about welcoming Trump to town. Democratic lawmakers and some residents have said Trump isn't welcome in the largely Latino border city based on his past anti-immigrant rhetoric. Authorities are scrutinizing a racist, anti-immigrant screed posted online shortly before the attack. Trump on Monday condemned racism and bigotry while addressing the nation for the first time since the shooting. ___ 4 p.m. The man suspected of shooting dozens of people in El Paso, Texas, says he has been unemployed for five months. Patrick Crusius says in his application for a public defender that he has no income, assets or expenses and that he has been living with his grandparents. The document was filed with the El Paso County district clerk's office Sunday and appears to indicate that the 21-year-old Crusius qualifies for a court-appointed attorney. Police shut down streets around Crusius' grandparents' home in the Dallas suburb of Allen in the hours after the mass shooting more than 600 miles (965 kilometers) away. The FBI says agents searched their home and two other homes where Crusius had stayed. Larry and Cynthia Brown said in a statement read by a family friend that their grandson moved out six weeks ago. ___ 3:50 p.m. Mexico's foreign secretary, Marcelo Ebrard, says the Mexican government considers the mass shooting at a Texas Walmart to be an act of terrorism against Mexican citizens on U.S. soil. Ebrard said at a news conference Monday that eight of the 22 people killed in Saturday's attack in El Paso were Mexican nationals, as were six of the roughly two dozen people who were wounded. He says he's been meeting with U.S. law enforcement and will forward what he has learned to Mexico's attorney general on Tuesday. Ebrard also says Mexico will participate in the investigation and trial of the man suspected of carrying out the attack. Authorities are investigating the attack as a possible hate crime aimed at immigrants. ___ 3:30 p.m. The governor of the Mexican state of Chihuahua says the attack at a Walmart in El Paso, Texas, was an "act of hate" against immigration, particularly immigration from Latin America. Chihuahua state Gov. Javier Corral Jurado told reporters outside of the Mexican consulate in El Paso on Monday that the Mexican government may approach Saturday's mass shooting as an act of terrorism. He says there's a growing "discriminatory and racist current" in the U.S. and that "we are living with the consequences of not stopping this narrative of hate." He says he has been meeting with Mexicans who were wounded in the attack and relatives of Mexicans who were killed. He says eight of the 22 people killed were Mexican citizens, including six from the state of Chihuahua, which is across the border from El Paso. ___ 11:30 a.m. The U.S. Border Patrol has re-opened its inland checkpoints around El Paso, Texas, after closing them for several months due to staffing shortages. The re-openings were announced Monday as El Paso grapples with the aftermath of a mass shooting that left more than 20 people dead. Authorities are investigating links between the suspected gunman and a racist, anti-immigrant screed that was posted online. Amid fears that immigrants in the U.S. illegally might not seek help after the shooting, U.S. Customs and Border Protection announced it wouldn't do any enforcement at area hospitals or shelters. The re-opened checkpoints are used by Border Patrol agents to check vehicles coming north for human or drug smuggling. The agency closed them in March because agents were needed to process and detain surging numbers of migrant parents and children. ___ 10:45 a.m. A hospital official says another victim of the weekend mass shooting in El Paso, Texas, has died. Dr. Stephen Flaherty, of the Del Sol Medical Center, says the patient was one of two victims of Saturday's attack to die at the hospital on Monday. Police earlier announced the death of one of the patients. The new deaths bring the death toll from the attack to 22. Roughly two dozen other people were wounded. The attack happened hours before a separate mass shooting in Dayton, Ohio, in which nine people were killed and others were wounded. ___ 9:45 a.m. Authorities say another person has died from a weekend mass shooting at a Walmart in El Paso, Texas, raising the death toll in that attack to 21. El Paso police tweeted that the latest victim died early Monday morning at a hospital. No other details were immediately provided. More than two dozen people were wounded in the attack. The suspected gunman, 21-year-old Patrick Crusius, has been booked on capital murder charges. Speaking from the White House on Monday, President Donald Trump condemned the El Paso mass shooting and another in Dayton, Ohio, hours later in his first public remarks since the attacks. ___ 12:15 a.m. Federal and state authorities continue to investigate the mass shooting at an El Paso, Texas, Walmart that left 20 people dead and more than two dozen others injured. Police said Sunday that all bodies have been removed from the store and its parking lot, and that the attack did not spread to other nearby shopping areas. Police Sgt. Robert Gomez says most of the victims were inside the store. Twenty-one-year-old Patrick Wood Crusius of Allen, Texas, has been booked on capital murder charges and jailed without bond. KDFW-TV reports his grandparents issued a statement Sunday saying they were "devastated" by the rampage. Allen is more than 600 miles (965 kilometers) from where Saturday's rampage occurred. The FBI says the suspect didn't have any contacts in El Paso. Detectives are also trying to determine with a racist, anti-immigrant screed posted online shortly before Saturday's shooting was written by Crusius. This image provided by the FBI shows Patrick Crusius. A gunman opened fire in an El Paso, Texas, shopping area packed with people during the busy back-to-school season Saturday, Aug. 3, 2019, killing over a dozen. The FBI identified the suspect as Crusius. (FBI via AP)People pray a makeshift memorial for victims of a mass shooting at a shopping complex Monday, Aug. 5, 2019, in El Paso, Texas. (AP Photo/John Locher)Edie Hallberg cries while speaking to police outside a Walmart store where a shooting occurred earlier in the day as she looks for her missing mother Angie Englisbee, who was in the store during the attack in El Paso, Texas, Saturday, Aug. 3, 2019. Multiple people were killed and one person was in custody after a shooter went on a rampage at a shopping mall, police in the Texas border town of El Paso said. (AP Photo/Andres Leighton)A relative of a victim of the Walmart mass shooting waits for information from authorities at the reunification center in El Paso, Texas, Sunday, Aug. 4, 2019. (AP Photo/Andres Leighton)Lisa Basa, left, and Ana Rodriguez buy El Paso Strong t-shirts from Proper Printshop's Alan Hudson just after they were printed Monday, Aug. 5, 2019, at his shop in El Paso, Texas. The proceeds from the sales of the shirts will be donated to the El Paso Community Foundation's El Paso Shooting Victim's Fund. (Mark Lambie/The El Paso Times via AP)Law enforcement officials block a road at the scene of a mass shooting at a shopping complex Sunday, Aug. 4, 2019, in El Paso, Texas. (AP Photo/John Locher)In this image provided by Beto O'Rourke's Facebook page, Presidential candidate and former congressman Beto O'Rourke, right, meets with mass shooting survivor, Rosemary, at University Medical Center in El Paso, Texas on Sunday, Aug. 4, 2019. A gunman opened fire in an El Paso shopping area during the busy back-to-school season Saturday, killing at least a dozen. (Beto O'Rourke Facebook via AP)People march in silence Sunday, Aug. 4, 2019, in El Paso, Texas, holding sunflowers and signs to honor the victims of the mass shooting that occurred in Walmart on Saturday, Aug. 3, 2019. (Lola Gomez/Austin American-Statesman via AP)Relatives of victims of the Walmart mass shooting wait for information from authorities at the reunification center in El Paso, Texas, Sunday, Aug. 4, 2019. (AP Photo/Andres Leighton)Someone left a couple of signs outside Del Sol Medical Center after a mass shooting occurred at Walmart early Saturday in El Paso, TX on Sunday, August 4, 2019. (Lola Gomez/Austin American-Statesman via AP)Members of the FBI evidence response team investigate the scene of a mass shooting at a shopping complex Sunday, Aug. 4, 2019, in El Paso, Texas. (AP Photo/John Locher)Locals bring flowers, stuffed animals, candles and posters to honor the memory of the victims of the mass shooting occurred in Walmart on Saturday morning in El Paso on Sunday, August 4, 2019. (Lola Gomez/Austin American-Statesman via AP)Lisa Basa, left, and Ana Rodriguez buy El Paso Strong t-shirts from Proper Printshop's Alan Hudson just after they were printed Monday, Aug. 5, 2019, at his shop in El Paso, Texas. The proceeds from the sales of the shirts will be donated to the El Paso Community Foundation's El Paso Shooting Victim's Fund. (Mark Lambie/The El Paso Times via AP)
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Messier 10 Messier 10 or M10 (also designated NGC 6254) is a globular cluster of stars in the equatorial constellation of Ophiuchus. The object was discovered by the French astronomer Charles Messier on May 29, 1764, who cataloged it as number 10 in his catalogue and described it as a "nebula without stars". In 1774, German astronomer Johann Elert Bode likewise called it a "nebulous patch without stars; very pale". Using larger instrumentation, German-born astronomer William Herschel was able to resolve the cluster into its individual members. He described it as a "beautiful cluster of extremely compressed stars". William Parsons, 3rd Earl of Rosse thought he could distinguish a dark lane through part of the cluster. The first to estimate the distance to the cluster was Harlow Shapley, although his derivation of 33,000 light years was much further than the modern value. The tidal radius of M10 is 19.3 arcminutes, which is about two-thirds of the apparent diameter of the Moon. Viewed through medium-sized telescopes it appears about half that size (8–9 arcminutes), as its bright core is only 35 light-years across. It has a core radius of 48 arcseconds and a half-mass radius of 147 arcseconds (2.5 arcminutes). M10 has a spatial diameter of 83 light-years and is estimated to be 14,300 light-years away from Earth. In terms of the abundance of elements other than hydrogen and helium, what astronomers term the metallicity, Messier 10 is "moderately metal–poor". The abundance of iron, measured as [Fe/H] equals , is only 3.5% of the abundance found at the surface of the Sun. The cluster shows evidence of being enriched by the elements generated through the s-process in massive stars and Type II supernovae. It shows little evidence of enrichment by Type 1a supernovae. Because binary stars are, on average, more massive than normal stars, the binaries tend to migrate toward the center of the cluster. The fraction of binary stars in the core region is about 14%. This proportion decreases with increasing radius to about 1.5% in the outlying regions of the cluster. Correspondingly, the core region contains a concentration of interaction-formed blue straggler stars, most of which formed 2–5 billion years ago. The density of stars in the core region is about 3.8 solar masses per cubic parsec. Four variable stars have been discovered in this cluster. The cluster is currently located about from the Galactic Center. It completes an orbit around the Milky Way galaxy about every 140 million years, during which it crosses the plane of the galactic disk every 53 million years. Its rosette orbit has an eccentricity of 0.21. References External links Messier 10, SEDS Messier pages Messier 10, Galactic Globular Clusters Database page Messier 010 Messier 010 010 Messier 010 17640529
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Q: Entity Attempting to update incorrect table / multiple instances of IEntityChangeTracker issue This is probably a stupid question but here I go anyways. Some facts. Im using entity 6.0.0.0 according to my refs. Im hitting an azure sql db. The project is based of a mvc default template thingo. So I'm attempting to add to table via the following code. Please note only 1 path has been attempted each time not all 3 or a combination at once. public User(UserModel userModel) { using (var db = new SqlDogContext()) { // Path 1 this seem like there is a better way but throws an exception anyways var sillyModel = new UserModel() { Id = userModel.Id }; db.UserLibarys.Add(new UserLib {User = sillyModel, Libary = RssLibObject}); db.SaveChanges(); db.UserLibarys.Add(new UserLib {User = sillyModel, Libary = KodiLibObject}); db.SaveChanges(); db.UserLibarys.Add(new UserLib {User = sillyModel, Libary = SoundCloudLibObject }); db.SaveChanges(); db.UserLibarys.Add(new UserLib {User = sillyModel, Libary = SpotifyBridgeObject }); db.SaveChanges(); // Path 2 I guess this would be ok var sillyModel = new UserModel() { Id = userModel.Id }; db.UserLibarys.Add(new UserLib { User = sillyModel, Libary = RssLibObject }); db.UserLibarys.Add(new UserLib { User = sillyModel, Libary = KodiLibObject }); db.UserLibarys.Add(new UserLib { User = sillyModel, Libary = SoundCloudLibObject }); db.UserLibarys.Add(new UserLib { User = sillyModel, Libary = SpotifyBridgeObject }); db.SaveChanges(); // Path 3 - What i want to use.. db.UserLibarys.Add(new UserLib { User = userModel, Libary = RssLibObject }); db.UserLibarys.Add(new UserLib { User = userModel, Libary = KodiLibObject }); db.UserLibarys.Add(new UserLib { User = userModel, Libary = SoundCloudLibObject }); db.UserLibarys.Add(new UserLib { User = userModel, Libary = SpotifyBridgeObject }); db.SaveChanges(); } } And I'm getting the following exception for path 1. {"Violation of PRIMARY KEY constraint 'PK_dbo.UserModels'. Cannot insert duplicate key in object 'dbo.UserModels'. The duplicate key value is (009d1c33-a3cf-49db-8243-ff8a447eff16). \r\nThe statement has been terminated."} And I'm getting the following exception for path 2. An exception of type 'System.Data.Entity.Validation.DbEntityValidationException' occurred in EntityFramework.dll but was not handled in user code Using this which I found somewhere on stackoverflow. try { // Your code... // Could also be before try if you know the exception occurs in SaveChanges db.SaveChanges(); } catch (DbEntityValidationException e) { foreach (var eve in e.EntityValidationErrors) { Console.WriteLine("Entity of type \"{0}\" in state \"{1}\" has the following validation errors:", eve.Entry.Entity.GetType().Name, eve.Entry.State); foreach (var ve in eve.ValidationErrors) { Console.WriteLine("- Property: \"{0}\", Error: \"{1}\"", ve.PropertyName, ve.ErrorMessage); } } throw; } I get the following message The User field is required. This makes very little sense to me because as I see it I'm providing it. And I'm getting the following exception for path 3. Additional information: An entity object cannot be referenced by multiple instances of IEntityChangeTracker. This is confusing to me because it looks like its updating the wrong table. Here Are my models public class UserLib { [Key] public int LibId { get; set; } public bool UserEnabled { get; set; } [Required] public virtual Lib Libary { get; set; } [Required] public virtual UserModel User { get; set; } } public class UserModel { [Key, ForeignKey("ApplicationUser")] public string Id { get; set; } public virtual UserLib Libary { get; set; } public virtual ApplicationUser ApplicationUser { get; set; } } public class Lib { public string Name { get; set; } public string Logo { get; set; } [Key] public int LibId { get; set; } public virtual UserLib UserLib { get; set; } } public class ApplicationUser : IdentityUser { public virtual UserModel MyUserModel { get; set; } // plus some other stuff in here that seems non relavent } Here is where the usermodel is created using (var db = new SqlDogContext()) { db.UserModels.Add( new UserModel() { Id = currentId } ); db.SaveChanges(); query = from b in db.UserModels where b.Id == currentId select b; } _CurrentUser = new User(query.First()); The end goal is to have one user for one UserModel One UserModel for Many UserLibaries And For UserLibaries to Have a foreign key to the library data base. So I have probably made a rookie mistake but can anyone see my issue :). A: You are trying to set the primary key: var sillyModel = new UserModel() { Id = userModel.Id }; and then store it multiple times which you can not do. Let entity framework set the primary keys. Also note that you do not have to keep calling SaveChanges() after each operation. You can do all of your inserts and then call it one time.
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Q: Permanent redirect from one domain to another but same host I had domain name which expired today and I have registered new domain with same name but different extension. New domain is in the same host where was old domain... just from http://example.com become http://example.net Now I have added in .htaccess this which I took from another question here on SO but when I go to old domain doesn't redirect me. Is this is because they are on the same hosting account? Options +FollowSymLinks RewriteEngine On RewriteCond %{SCRIPT_FILENAME} !-d RewriteCond %{SCRIPT_FILENAME} !-f RewriteBase / RewriteCond %{HTTP_HOST} !^example\.com$ [NC] RewriteRule ^(.*)$ http://example.net [R=301,L] New domain is working without any problems and is loading correctly if I go directly. A: If you don't own example.com, you have no control over where it is hosted now. Read up on how DNS works https://en.wikipedia.org/wiki/Domain_Name_System
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Phonon interference effects in molecular junctions. We study coherent phonon transport through organic, π-conjugated molecules. Using first principles calculations and Green's function methods, we find that the phonon transmission function in cross-conjugated molecules, like meta-connected benzene, exhibits destructive quantum interference features very analogous to those observed theoretically and experimentally for electron transport in similar molecules. The destructive interference features observed in four different cross-conjugated molecules significantly reduce the thermal conductance with respect to linear conjugated analogues. Such control of the thermal conductance by chemical modifications could be important for thermoelectric applications of molecular junctions.
{ "pile_set_name": "PubMed Abstracts" }
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Q: How to implement drag-drop directive for Ionic? //long-press.directive.d.ts import { ElementRef, EventEmitter, OnDestroy, OnInit, NgZone } from '@angular/core'; import { Gesture } from 'ionic-angular/gestures/gesture'; export declare class LongPressDirective implements OnInit, OnDestroy { zone: NgZone; interval: number; onPressStart: EventEmitter<any>; onPressing: EventEmitter<any>; onPressEnd: EventEmitter<any>; el: HTMLElement; pressGesture: Gesture; int: any; constructor(zone: NgZone, el: ElementRef); ngOnInit(): void; ngOnDestroy(): void; } //long-press.drective.js "use strict"; Object.defineProperty(exports, "__esModule", { value: true }); var core_1 = require("@angular/core"); var gesture_1 = require("ionic-angular/gestures/gesture"); var LongPressDirective = (function () { function LongPressDirective(zone, el) { this.zone = zone; this.onPressStart = new core_1.EventEmitter(); this.onPressing = new core_1.EventEmitter(); this.onPressEnd = new core_1.EventEmitter(); this.el = el.nativeElement; } LongPressDirective.prototype.ngOnInit = function () { var _this = this; if (!this.interval) this.interval = 500; if (this.interval < 40) { throw new Error('A limit of 40ms is imposed so you don\'t destroy device performance. If you need less than a 40ms interval, please file an issue explaining your use case.'); } this.pressGesture = new gesture_1.Gesture(this.el); this.pressGesture.listen(); this.pressGesture.on('press', function (e) { _this.onPressStart.emit(e); _this.zone.run(function () { _this.int = setInterval(function () { _this.onPressing.emit(); }, _this.interval); }); }); this.pressGesture.on('pressup', function (e) { _this.zone.run(function () { clearInterval(_this.int); }); _this.onPressEnd.emit(); }); }; LongPressDirective.prototype.ngOnDestroy = function () { var _this = this; this.zone.run(function () { clearInterval(_this.int); }); this.onPressEnd.emit(); this.pressGesture.destroy(); }; return LongPressDirective; }()); LongPressDirective.decorators = [ { type: core_1.Directive, args: [{ selector: '[ion-long-press]' },] }, ]; /** @nocollapse */ LongPressDirective.ctorParameters = function () { return [ { type: core_1.NgZone, }, { type: core_1.ElementRef, }, ]; }; LongPressDirective.propDecorators = { 'interval': [{ type: core_1.Input },], 'onPressStart': [{ type: core_1.Output },], 'onPressing': [{ type: core_1.Output },], 'onPressEnd': [{ type: core_1.Output },], }; exports.LongPressDirective = LongPressDirective; //# sourceMappingURL=long-press.directive.js.map This is implementation of 'press', 'press-up' event. This directive intends to build upon the existing Hammer.JS press event that Ionic uses for long pressing, by giving you interval emission. https://www.npmjs.com/package/ionic-long-press I want to add 'drag'-'drop' event. I am beginner of angular. Expert's help is needed. Thanks. A: I solved the problem using this plugin. https://github.com/AbineshSrishti/ionic2-selection-card-drag
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Consumer-professional collaboration for evaluation in neighborhood mental health programs. Neighborhood mental health programs are challenged with the scientific and fiscal necessity of evaluating their services. Since most such programs are joint endeavors of neighborhood residents (usually a consumer board) and nonneighborhood professionals, such evaluative efforts require the sanction and collaboration of both groups to be maximally effective. However, the authors point out that collaboration is often strained by lack of trust and conflicts of interest. Study design may fail to consider neighborhood values, with the result that the provision of services is impeded, consumers are frightened or coerced, the role of paraprofessionals is threatened, and the consumer board's responsibilities to the neighborhood are ignored. The authors discuss those four issues and suggest ways of resolving them.
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Mark J. Aquilino, President of Outdoor Pride Landscaping in Manchester, NH, discusses how data is used in every aspect of their snow and ice management company, including training and maintenance, stocking equipment, and using technology for accurate record keeping. About SIMA Empowering snow & ice management for success is our mission. We are a non-profit trade association with a focus on training, events, and best practices related to snow plowing, ice management, and business management.
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