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2,500 | 2,575 | Vitrectomy retinotomy aspiration biopsy of choroidal tumors
We used an investigational technique for the biopsy of intraocular tumors to aid in the diagnosis of three choroidal tumors.
A three-port trans-pars plana vitrectomy was performed in conjunction with retinotomy, tumor biopsy, endophotocoagulation, and air-f... | C11 |
2,501 | 8,626 | Anterior segment ischemia: a complication of retinal detachment repair in a patient with sickle cell trait.
Anterior segment ischemia (ASI) is a dreaded complication of retinal detachment surgery particularly in patients with predisposing factors such as sickle cell disease.
We report a case of ASI after scleral buck... | C11 |
2,502 | 6,458 | Pseudoexfoliative fibrillopathy in the skin of patients with ocular pseudoexfoliation.
In addition to its occurrence within the eye, pseudoexfoliative fibrillopathy has been reported in the conjunctiva and around a posterior ciliary artery.
To determine whether it has a more diffuse extraocular distribution, we studi... | C11 |
2,503 | 7,646 | Endophthalmitis due to Sporothrix schenckii after penetrating ocular injury.
A 13-year-old boy developed endophthalmitis from traumatic inoculation of vegetable material penetrating his right eye.
Sporothrix schenckii was morphologically identified from the intraocular fluids.
However, repeated attempts to culture t... | C11 |
2,504 | 3,263 | Cytopathology of adenovirus keratitis by replica technique.
Corneal replicas were made from the severely affected eyes of 12 patients presenting with typical signs and symptoms of epidemic keratoconjunctivitis.
Adenovirus was isolated from the eyes.
Histopathological study of the replicas and cytology of diseased ce... | C11 |
2,505 | 6,056 | Cataract extraction in uveitis patients.
Cataracts are known to develop at an accelerated rate in many forms of uveitis.
Until recently, cataract surgery in such eyes was regarded as a hazardous procedure that yielded unpredictable and often discouraging results.
Recent evidence from a number of reports suggests tha... | C11 |
2,506 | 8,783 | Recession of the superior oblique tendon in A-pattern strabismus.
We performed 9 to 12 mm of recession of the superior oblique tendon for A-pattern strabismus in 10 patients.
The average preoperative A-pattern measured 29.4 prism dioptres (PD), and the average pattern correction was 29.3 PD.
All patients had a resid... | C11 |
2,507 | 5,891 | Long-term results following 131I treatment for Graves' disease in Hong Kong Chinese--discriminant factors predicting hypothyroidism.
The clinical outcome of 1028 Hong Kong Chinese patients with Graves' disease treated with radioiodine therapy and followed for a mean of 9.85 +/- 4.84 years (range 2-20) was analysed.
R... | C11 |
2,508 | 9,005 | A new ophthalmic microtrephine.
We present a new instrument designed to facilitate the microtrephination of tissues required in various ophthalmic procedures.
This microtrephine is a 21-gauge stainless steel tube, 0.81 mm in diameter and 16 mm long, with a sharpened cutting end and a plastic finger-grip area to facil... | C11 |
2,509 | 7,377 | Sports-related ocular trauma.
A prospective evaluation of all patients presenting with a sports-related ocular injury during a 1-year (4-season) period was conducted.
Of the 202 patients evaluated, 28 (13.8%) required hospitalization and 11 (5.6%) required intraocular surgery.
Twenty-six patients (12.8%) sustained p... | C11 |
2,510 | 327 | Ocular complications of rheumatic diseases of childhood.
The association between inflammatory ocular and articular disease is a strong one, although the pathogenesis of this relationship is obscure.
For the physician or surgeon caring for children with chronic arthritis, awareness of the risk of chronic asymptomatic ... | C11 |
2,511 | 7,386 | Longitudinal study of lesions of the posterior segment in onchocerciasis.
Onchocerciasis is a major cause of blindness, and much of the blindness due to onchocerciasis is caused by chorioretinitis.
Little is known about the progression of lesions in the posterior segment in either untreated or treated disease.
The a... | C11 |
2,512 | 5,144 | Visual impairment in a rural Appalachian community. Prevalence and causes.
A population-based survey of 1136 subjects aged 40 years and older was conducted in a rural valley of Kentucky to determine the nature and extent of visual disability in an underserved area of rural America.
Data on corrected visual acuity and... | C11 |
2,513 | 3,266 | Multifocal posterior uveitis: clinical and pathological findings.
A pathological study was performed on the necropsy eyes of a 59-year old-woman who had suffered for nine years from multifocal posterior uveitis.
The disease had been controlled by steroid therapy with good preservation of visual function.
Extensive i... | C11 |
2,514 | 7,712 | Antibodies to Epstein-Barr virus in iridocorneal endothelial syndrome.
Antibody titers to Epstein-Barr virus were determined in 13 patients with iridocorneal endothelial syndrome and in 13 healthy race-, age-, and sex-matched controls.
Both the geometric mean titer of IgG antibodies to the Epstein-Barr virus capsid a... | C11 |
2,515 | 5,579 | Clinical spectrum of leber's congenital amaurosis in the second to fourth decades of life.
Leber's congenital amaurosis is a type of congenital retinitis pigmentosa in which the fundus abnormalities are extremely variable and to some extent age dependent.
Most cases are seen in infancy.
The retinal, electroretinogra... | C11 |
2,516 | 9,447 | Effectiveness of low dose erythropoietin: a possible advantage of high flux hemodialysis.
Recombinant human erythropoietin (EPO) was administered to 32 stable out-patients with end-stage renal disease (ESRD) on a priority basis three times a week.
All patients underwent dialysis with polysulfone hollow fiber dialyzer... | C15 |
2,517 | 3,775 | A case of massive true thymic hyperplasia with non-Hodgkin's lymphoma.
A case of massive true thymic hyperplasia with non-Hodgkin's lymphoma of the mediastinum is reported in a 14-year-old boy.
Computed tomographic scan of the chest showed a mass of the anterior mediastinum and conspicuous swelling of the lymph nodes... | C15 |
2,518 | 5,691 | Eosinophilia-myalgia syndrome linked to tryptophan.
Eosinophilia-myalgia syndrome has been linked to ingestion of tryptophan, but the exact cause of this recently recognized syndrome is unclear.
As in other reported cases, the disease in the patient described here developed while she was taking tryptophan.
Although ... | C15 |
2,519 | 6,402 | Disseminated intravascular coagulation due to intravenous administration of hetastarch.
Disseminated intravascular coagulation occurred in a patient after intravenous administration of hetastarch.
The onset was acute within 3 hours after exposure to the agent and the course was fulminating.
The patient died in 48 ho... | C15 |
2,520 | 3,522 | Splenic septic emboli in endocarditis.
The significance of septic emboli to the spleen is inferred by the frequency of septic emboli in general seen in patients with left-sided infective endocarditis who are referred for valve replacement.
To determine the proper management of splenic infarcts and abscess due to sept... | C15 |
2,521 | 9,473 | Leukocyte overshoot: a new sign of bioincompatibility in fast hemodialysis.
A high blood flow of 400 ml/min induces leukocytosis after 2 hr of dialysis with leukocyte concentrations of 110-150% of predialysis values.
The leukocytosis occurs with both low and high biocompatible membranes, such as Cuprophan, Hemophan, ... | C15 |
2,522 | 2,392 | Primary splenic lymphocyte-depletion Hodgkin's disease.
A case of lymphocyte-depletion Hodgkin's disease is described for the purpose of reviewing the criteria currently used to distinguish this disease from other pleomorphic large-cell malignancies.
A 76-year-old man with a 3-month history of daily fevers underwent ... | C15 |
2,523 | 71 | Effects of recombinant human interleukin-3 in aplastic anemia.
In a phase I/II study, nine patients with aplastic anemia were treated with recombinant human interleukin-3 (rhIL-3) to assess the toxicity and biologic effects of this multipotential hematopoietic growth factor.
Doses ranging from 250 micrograms/m2 to 50... | C15 |
2,524 | 4,306 | Cells immunoreactive for neuropeptide in human thymomas.
The presence of opioid peptides, bombesin, and substance P was investigated by immunohistochemistry in tissue sections from six human thymomas.
The number of immunoreactive cells seemed to vary from one case to another.
Ultrastructural investigation, showing t... | C15 |
2,525 | 6,934 | Lovastatin. Warfarin interaction.
Two patients who developed hypoprothrombinemia and bleeding due to lovastatin-warfarin drug interaction are described.
Because of the wider use of lovastatin and warfarin, heightened clinical awareness of this potentially serious interaction must be publicized.
Therefore, prothrombi... | C15 |
2,526 | 4,529 | Small bile duct abnormalities in sarcoidosis.
We report four patients with hepatic involvement of sarcoidosis manifested primarily by bile duct depletion.
The patients developed fever, weight loss, anorexia, a markedly elevated alkaline phosphatase, and mildly abnormal serum levels of aspartate aminotransferase.
End... | C15 |
2,527 | 5,270 | Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients.
The efficacy of the oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one (L1) was compared with that of subcutaneous desferrioxamine in 26 patients with transfusional iron overload.
Immediately after red-cell transfusion, 20 patients wer... | C15 |
2,528 | 5,265 | Value of antigen detection in predicting invasive pulmonary aspergillosis
Two ELISAs were used to detect serum and urinary aspergillus antigen in 121 patients who were profoundly neutropenic after leukaemia therapy or bone marrow transplantation.
The presence of antigen correctly predicted development of invasive pu... | C15 |
2,529 | 5,506 | Antibodies to synthetic peptide (125-148) of the alpha-subunit of human nicotinic acetylcholine receptor in sera from patients with myasthenia gravis.
We measured the amount of antibodies to a synthetic peptide that corresponds to the alpha-subunit residues Lys125-Thr148 of human acetylcholine receptor (AChR) in myast... | C15 |
2,530 | 7,857 | Alterations in pulmonary mechanics after transfusion in anemic preterm infants.
Pulmonary mechanics were studied in ten anemic preterm infants using an esophageal balloon and mask, before and after transfusion with 10 ml/kg of packed RBC.
Their mean birth weight was 1212 +/- 323 g and gestational age was 29.27 +/- 2.... | C15 |
2,531 | 3,401 | Sarcoid reaction mimicking intrathoracic dissemination of testicular cancer.
The close observation of patients treated for testicular cancer led to the suspicion of intrathoracic and/or mediastinal metastases on radiologic examination in a number of patients without other evidence of relapse.
This report presents two... | C15 |
2,532 | 864 | Scleroderma and L-tryptophan: a possible explanation of the eosinophilia-myalgia syndrome.
Scleroderma developed in six women who were taking L-tryptophan.
Fasciitis and morphea were most common, but one patient had pleural effusion, hypertension, and signs of cardiac and kidney failure.
In five patients the biopsy ... | C15 |
2,533 | 2,067 | Acute promyelocytic leukemia: impact of hemorrhagic complications on response to induction chemotherapy and survival.
From 1976 to 1989, 21 adult patients with previously untreated acute promyelocytic leukemia were seen at the University of Virginia Hospital.
We reviewed their cases retrospectively to determine the i... | C15 |
2,534 | 7,088 | Plasma thrombomodulin in health and diseases.
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by immunoblot analysis of plasma thrombomodulin concentrate revealed that four degraded forms of thrombomodulin with different molecular weights are present in plasma.
Plasma concentrations of thrombomodul... | C15 |
2,535 | 2,262 | Tryptophan-induced eosinophilia-myalgia syndrome
Eight patients who became ill while taking tryptophan had myalgia, fatigue, rash, fever, edema, alopecia, arthralgias, diminished joint motion, skin tightening, muscle cramping, and distal paresthesias.
Three had shortness of breath, and one had pulmonary hypertension... | C15 |
2,536 | 8,574 | Corporectomy for intractable sickle-associated priapism.
Priapism is a complication of sickle cell disease, and for those with severe prolonged attacks, it is serious, often resulting in permanent sexual impairment.
Treatment is frustrating, and psychological consequences may be profound.
A 20-year-old sickle cell p... | C15 |
2,537 | 9,180 | Synchronous diffuse well-differentiated lymphocytic lymphoma and gastric adenocarcinoma presenting as splenomegaly and iron deficiency anemia.
Diffuse well-differentiated lymphocytic lymphoma (D-WDLL) and chronic lymphocytic lymphoma (CLL) represent closely related neoplasms which may have indolent courses.
Dating ba... | C15 |
2,538 | 2,173 | The hyperimmunoglobulinaemia E and recurrent infections syndrome in an adult [published erratum appears in Thorax 1990 Dec;45(12):984]
A 27 year old white woman with a history of chronic eczema and episodes of serious infection of the chest, skin, and bone presented with acute respiratory failure.
She was found to h... | C15 |
2,539 | 803 | Essential fatty acid deficiency ameliorates acute renal dysfunction in the rat after the administration of the aminonucleoside of puromycin.
The administration of the aminonucleoside of puromycin (PAN) to rats causes the nephrotic syndrome that is associated with an acute decline in renal function, and an interstitial... | C15 |
2,540 | 536 | Effect of cyclosporin on generalized Shwartzman reaction in diabetic rats.
The effect of cyclosporin (CsA) on the endotoxin-induced generalized Shwartzman reaction (GSR) was studied in diabetic and nondiabetic rats.
After 4.5 wk of diabetes, CsA (20 mg/kg) or intralipid as a control substance was given intraperitonea... | C15 |
2,541 | 7,218 | L-tryptophan implicated in human eosinophilia-myalgia syndrome causes fasciitis and perimyositis in the Lewis rat.
Tryptophan-associated eosinophilia-myalgia syndrome (L-TRP-EMS) is a newly described syndrome which occurred in epidemic fashion in the United States in the summer and fall of 1989.
Epidemiologic data ha... | C15 |
2,542 | 6,908 | Job's syndrome: a rare cause of recurrent lung abscess in childhood.
A clinical syndrome characterized by recurrent staphylococcal infection of the skin and respiratory tract from birth was described in 1966 and referred to as Job's syndrome.
Marked hyperimmunoglobulinemia E was later found to be associated with this... | C15 |
2,543 | 2,881 | SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits.
To investigate the potential use of SCH-39304 for the prevention and treatment of disseminated candidiasis in granulocytopenic patients, we studied its in vivo antifungal activity as preventive, early, and late ... | C15 |
2,544 | 96 | Effects of recombinant human interleukin-3 on human hematopoietic progenitor and precursor cells in vivo.
DNA-synthesis rates and concentrations of bone marrow (BM) and peripheral blood (PB) progenitor cells were studied in 22 patients treated with recombinant human interleukin-3 (rhIL3) as part of a clinical phase I/... | C15 |
2,545 | 3,369 | Erythema infectiosum and pregnancy-related complications
Erythema infectiosum, an acute, communicable viral disease with a highly distinctive exanthem, follows the usual course of a self-limiting benign disease.
In pregnant women, however, it may be associated with fetal death and nonimmune hydrops fetalis.
Because... | C15 |
2,546 | 5,667 | Peripheral vascular disorders. Assessment and intervention.
Peripheral vascular diseases are being seen with increased frequency in the health care setting today.
It is imperative that nurses have a clear understanding of arterial, venous, and lymphatic circulatory mechanisms as well as the pathophysiologic changes t... | C15 |
2,547 | 6,337 | Extramedullary hematopoiesis involving the esophagus in myelofibrosis.
In this report, we describe a case of myelofibrosis with myeloid metaplasia; a 53-yr-old man was splenectomized for a massively enlarged spleen in which multiple foci of myeloid metaplasia were histologically demonstrated.
The patient was referred... | C15 |
2,548 | 4,374 | Mandibular osteomyelitis in a patient with sickle cell anemia: report of case.
A case is presented in which mandibular osteomyelitis and mental nerve paresthesia developed in a patient with sickle cell anemia.
This infection appeared to precipitate a sickle cell crisis.
The mechanisms for these patients' propensity ... | C15 |
2,549 | 7,585 | Angiocentric lymphoma with histologic features of neoplastic angioendotheliomatosis presenting with predominant respiratory and hematologic manifestations. Report of a case and review of the literature
Neoplastic angioendotheliomatosis (NAE) is a rare fatal disease characterized by widespread intravascular proliferat... | C15 |
2,550 | 2,526 | The natural history of thrombocytopenia associated with preeclampsia.
Sixty-one of 375 women with hypertension and preeclampsia in a 48-month period had thrombocytopenia.
By postpartum day 3, 90% of these women had rising platelet counts, and by day 4, 59 of 61 women had counts greater than 100,000/mm3.
The two exce... | C15 |
2,551 | 7,436 | A new surgical approach in genital lymphedema.
A new surgical approach has been used in a case of genital lymphedema.
After resection of the lymphedematous mass, U-shaped flaps were made from the suprapubic region anteriorly and the posterior scrotal skin posteriorly.
The denuded penis was transposed to its original... | C15 |
2,552 | 3,412 | Effect of granulocyte colony-stimulating factor on neutropenia due to chemotherapy for non-Hodgkin's lymphoma.
The authors administered recombinant human granulocyte colony-stimulating factor (rhG-CSF) to 16 patients with advanced non-Hodgkin's lymphoma treated with combination chemotherapy.
Groups of three to five p... | C15 |
2,553 | 2,533 | Management and outcomes of pregnancies complicated by human B19 parvovirus infection: a prospective study
During a large statewide outbreak of fifth disease in Connecticut in 1988, 39 pregnant women were identified who had serologic evidence of recent human B19 parvovirus infection.
The patients were followed up pro... | C15 |
2,554 | 8,506 | Giant lymph node hyperplasia of the lung (Castleman's disease) associated with recurrent pleural effusion.
A case of giant lymph node hyperplasia (Castleman's disease) of the lung presented with pleural effusion (which was recurrent), an unusual complication.
The patient was treated with pneumonectomy and has survive... | C15 |
2,555 | 838 | Effect of sample volume on yield of positive blood cultures from adult patients with haematological malignancy.
Six hundred and sixteen blood samples from patients with haematological malignancy were each distributed equally among three identical cells in a Malthus Microbiological Growth Analyser.
The mean (SD) volum... | C15 |
2,556 | 5,252 | Coagulation factor abnormalities as possible thrombotic risk factors after Fontan operations.
Severe thromboembolism occurred in 3 of 37 patients who had undergone Fontan-type operations for correction of congenital heart defects several months to years after the operation.
The patients were screened for coagulation ... | C15 |
2,557 | 3,280 | The hematopoietic defect in aplastic anemia assessed by long-term marrow culture.
Thirty-two patients with aplastic anemia (AA) have been studied using the long-term bone marrow culture (LTBMC) system.
Of these patients, 26 had been treated with immunosuppressive therapy including antilymphocyte globulin (ALG) with o... | C15 |
2,558 | 2,420 | Thymic hyperplasia. A clue to the diagnosis of hyperthyroidism.
The association of simultaneous abnormalities of the thyroid and thymus is well documented, particularly in the case of Graves' disease.
We present a case of a natural death following thyroid storm in which marked thymic hyperplasia was present.
This fi... | C15 |
2,559 | 8,208 | A constitutive antibody in normal human serum directed against rabbit bone marrow cells: lack in parturients, neonates, and hematologic disorders.
Normal human serum effectively inhibits a bioassay for erythropoietin based on DNA synthesis by rabbit erythroid precursors.
This heat-sensitive inhibitory activity is rea... | C15 |
2,560 | 5,385 | Molecular defect of the band 3 protein in southeast Asian ovalocytosis
BACKGROUND.
Southeast Asian ovalocytosis is a form of hereditary elliptocytosis in which the red cells are rigid and resistant to malaria invasion.
The underlying molecular defect is unknown.
METHODS AND RESULTS.
We studied the red cells of 54... | C15 |
2,561 | 3,468 | Anaesthesia for renal transplantation in sickle cell disease.
Sickle cell disease (SCD) is associated with many pathological and functional abnormalities affecting all organ systems.
Renal manifestations of SCD may result in end-stage renal disease (ESRD), which can be treated by chronic haemodialysis or renal transp... | C15 |
2,562 | 7,214 | Human neutrophil cytochrome b light chain (p22-phox). Gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease.
A membrane-bound cytochrome b, a heterodimer formed by a 91-kD glycoprotein (heavy chain) and a 22-kD polypeptide (light chain), is an esse... | C15 |
2,563 | 4,093 | Magnetic resonance imaging of the bone marrow following treatment with recombinant human erythropoietin in patients with end-stage renal disease.
We used magnetic resonance imaging (MRI) to study vertebral bone marrow in hemodialysis patients during treatment with recombinant human erythropoietin (rHuEPO).
We found c... | C15 |
2,564 | 6,139 | Evaluation of the manual hexadimethrine bromide (Polybrene) technique in the investigation of autoimmune hemolytic anemia.
The use of the direct manual hexadimethrine bromide (Polybrene) test (DPT) in the investigation of patients for autoimmune hemolytic anemia (AIHA) was evaluated.
Seventy-nine blood samples from 6... | C15 |
2,565 | 5,107 | Nonsteroidal anti-inflammatory drugs in the treatment of eosinophilic cystitis.
A 30-year-old white woman with urinary frequency, left costovertebral angle pain and hematuria had left hydronephrosis, a marked decrease in bladder capacity and severe eosinophilic cystitis on biopsy.
She was treated with a nonsteroidal ... | C15 |
2,566 | 4,477 | Down regulation in hypersensitivity pneumonitis.
Levels of soluble interleukin-2 receptor (sol-IL-2R) in the bronchoalveolar lavage fluid (BALF) of pigeon breeders with hypersensitivity pneumonitis were compared with BALF levels in asymptomatic pigeon breeders who had been exposed to pigeon allergens for an equivalent... | C15 |
2,567 | 2,907 | Prognosis of chronic granulomatous disease.
The records of 28 patients with chronic granulomatous disease born over a 32 year period were reviewed.
The characteristics of the group, and the frequency with which various clinical and laboratory features had been recorded, was assessed.
Nine patients were known to have... | C15 |
2,568 | 8,784 | Angle-closure glaucoma as initial presentation of myelodysplastic syndrome.
A 57-year-old man presented with proptosis of the right eye and findings consistent with bilateral angle-closure glaucoma.
Subsequent evaluation revealed severe bilateral uveal effusions and associated nonrhegmatogenous retinal detachments, w... | C15 |
2,569 | 7,905 | Osler-Weber-Rendu disease and pulmonary arteriovenous fistulas. Deterioration and embolotherapy during pregnancy.
Several reports have implicated pregnancy as a cause of deterioration in patients with pulmonary arteriovenous fistulas.
We report a 27-year-old woman with multiple pulmonary arteriovenous fistulas who re... | C15 |
2,570 | 5,387 | The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens
BACKGROUND.
Bacillary angiomatosis is an infectious disease causing proliferation of small blood vessels in the skin and visceral organs of patients with human immunodeficiency virus infection and other immunocompromised h... | C15 |
2,571 | 6,321 | Lead poisoning and thalassemia trait or iron deficiency. The value of the red blood cell distribution width.
The cause of microcytosis and anemia in lead poisoning was investigated using red blood cell distribution width as a screening parameter in 21 consecutive patients with lead poisoning and seven nonrandomly sele... | C15 |
2,572 | 6,911 | Empiric treatment of fungal infections in the neutropenic host. Review of the literature and guidelines for use.
Persistent fever that is refractory to broad-spectrum antibacterials is common in neutropenic patients undergoing induction chemotherapy of acute leukemia.
Clinical experience suggests that many of these p... | C15 |
2,573 | 8,806 | Primary malignant lymphomas of the spleen. A morphologic and immunohistochemical analysis of 17 cases.
Seventeen cases of primary malignant lymphoma of the spleen (PMLS) were identified among 500 splenectomy specimens showing involvement by Hodgkin's disease or non-Hodgkin's lymphoma.
All PMLS represented non-Hodgkin... | C15 |
2,574 | 5,464 | Spinal cord thromboplastin-induced coagulopathy in a rabbit model.
Coagulopathy results from many diverse events, including several neurogenic causes.
Using a rabbit model, we produced coagulopathy by injecting autologous spinal cord and extracted thromboplastin intravenously.
Serial coagulation panels were performe... | C15 |
2,575 | 9,936 | Microscopic Wegener's disease: a particular form of Wegener's granulomatosis.
We describe a case of Wegener's granulomatosis in which the disease was manifested with crescentic glomerulonephritis, upper airway ulcerations, and microangiopathic hemolytic anemia with consumptive coagulopathy.
No granuloma was identifie... | C15 |
2,576 | 6,907 | Malignant thymoma presenting as intracardiac tumor and superior vena caval obstruction.
A case of malignant thymoma with intracardiac infiltration and intrinsic superior vena caval obstruction due to the tumor is reported.
Intracardiac invasion by a thymoma is rare and for this reason is believed worthy of a report. | C15 |
2,577 | 9,134 | Thrombotic thrombocytopenic purpura treated with high-dose intravenous gamma globulin.
Plasma infusion and/or plasma exchange has become standard therapy in the treatment of thrombotic thrombocytopenic purpura (TTP).
The management of patients in whom such primary therapy fails is difficult and uncertain.
We have de... | C15 |
2,578 | 5,186 | Nephron function in the early phase of ischemic renal failure. Significance of erythrocyte trapping.
Trapping of red blood cells (RBCs) in renal medulla vasculature in postischemic acute renal failure (ARF) was found to depend upon the length of the ischemic period.
Thus trapping occurred after 45 minutes but not 25 ... | C15 |
2,579 | 6,338 | Diffuse hemangiomatosis of the spleen: splenic hemangiomatosis presenting with giant splenomegaly, anemia, and thrombocytopenia.
In an elderly patient with oligosymptomatic giant splenomegaly, clinical and laboratory data were nondiagnostic, while nonhomogeneous splenic enlargement was the only finding detected by ima... | C15 |
2,580 | 3,378 | A phase I study of 4'-0-tetrahydropyranyladriamycin. Clinical pharmacology and pharmacokinetics.
A Phase I study of intravenous (IV) bolus 4'-0-tetrahydropyranyladriamycin (Pirarubicin) was done in 55 patients in good performance status with refractory tumors.
Twenty-six had minimal prior therapy (good risk), 23 had ... | C15 |
2,581 | 8,328 | Paraneoplastic pemphigus. An autoimmune mucocutaneous disease associated with neoplasia.
BACKGROUND and METHODS.
We describe five patients with underlying neoplasms in whom painful mucosal ulcerations and polymorphous skin lesions developed, usually with progression to blistering eruptions on the trunk and extremitie... | C15 |
2,582 | 2,803 | Ciliary motility in two patients with yellow nail syndrome and recurrent sinopulmonary infections.
The yellow nail syndrome (YNS) is described as a combination of yellow nails, chronic lymphedema, pleural effusions, and recurrent sinopulmonary infections, but all these features need not be present for the diagnosis.
... | C15 |
2,583 | 5,789 | Hypomutability in Fanconi anemia cells is associated with increased deletion frequency at the HPRT locus.
Fanconi anemia (FA) is an inherited human disorder associated with a predisposition to cancer and characterized by anomalies in the processing of DNA cross-links and certain monoadducts.
We reported previously th... | C15 |
2,584 | 9,798 | Colony-stimulating factors.
Recombinant hematopoietic colony-stimulating factors have profound effects on developing and mature granulocytes, macrophages, and lymphocytes.
Use of these agents for treatment of disease may result in a variety of adverse cutaneous reactions.
The recent discovery of colony-stimulating f... | C15 |
2,585 | 7,628 | Platelet aggregation is not necessary for occurrence of Raynaud's phenomenon: a clinical history and laboratory results.
"Raynaud's phenomenon (R.P.) is characterized by a spastic vasoconstriction of hand and/or feet extremities leading to painful ischemic attacks.
In the pathogeny of this syndrome the role of a plat... | C15 |
2,586 | 2,753 | Adverse reactions to heparin [clinical conference]
Heparin is a medication that has gained widespread use in clinical medicine as the therapy of choice for acute anticoagulation in the prevention and treatment of thromboembolic disease.
Therapy with heparin is associated with many potential adverse side effects.
Hep... | C15 |
2,587 | 5,689 | When a patient with a bleeding disorder needs dental work. How you can work with the dentist to prevent a crisis
Patients with bleeding disorders need close cooperation between their physician and their dental practitioner to receive safe, comprehensive dental care.
When indicated, physicians must advise a compromis... | C15 |
2,588 | 6,138 | Viral infections in transfusion-dependent patients with beta-thalassemia major: the predominant role of cytomegalovirus.
For 9 months, 38 transfusion-dependent patients with beta-thalassemia, ranging in age from 3.4 to 19.1 years, were observed for serologic evidence of viral infections, by the collection of serial se... | C15 |
2,589 | 2,209 | Autoimmune hemolytic anemia in Kawasaki disease: a case report
A 3-year-old boy presented with the fever, conjunctivitis, rash, and lymphadenopathy diagnostic of Kawasaki disease.
Treatment with antibiotics, aspirin, and intravenous immunoglobulin was instituted.
The hematocrit decreased from 35 percent on admissio... | C15 |
2,590 | 2,914 | Social integration of the older thalassaemic patient.
Because social policy favours the fullest possible social integration of chronically ill patients, we have evaluated the facilities that are needed to achieve this for patients with beta thalassaemia major in the light of the therapeutic advances that now permit th... | C15 |
2,591 | 7,109 | Chronic anaemia, hyperbaric oxygen and tumour radiosensitivity.
Anaemia is an important factor in the response of some human tumours to radiotherapy.
The outcome is also influenced by whether the treatment is given in air or high pressure oxygen (HPO).
The present study examined the relationship between anaemia and ... | C15 |
2,592 | 6,358 | The role of aluminum in the functional iron deficiency of patients treated with erythropoietin: case report of clinical characteristics and response to treatment.
The quantitative variation among patients in their response to erythropoietin can be explained, in part, by factors that can independently cause anemia in p... | C15 |
2,593 | 3,740 | Cardiopulmonary assessment in beta-thalassemia major.
Thalassemia patients succumb at a young age to congestive heart failure.
Hitherto, attention has been focused on left ventricular function.
This report emphasizes right ventricular dysfunction and abnormal pulmonary function.
We performed cardiopulmonary evaluat... | C15 |
2,594 | 6,013 | Cytophagic histiocytic panniculitis evolving into total lipodystrophy.
A 15-year-old boy had persistent fever with severe neutropenia, thrombocytopenia, coagulation disorder, and marked elevation of lactate dehydrogenase values.
A diagnosis of cytophagic histiocytic panniculitis was made after repeated skin biopsies.... | C15 |
2,595 | 9,278 | The effect of corticosteroid or methotrexate therapy on lung lymphocytes and macrophages in sarcoidosis.
Methotrexate appears to be an effective alternative to corticosteroid therapy for some patients with sarcoidosis.
The mechanism of action of methotrexate as an immunosuppressive is unknown.
Patients with symptoma... | C15 |
2,596 | 7,100 | Molecular and hematologic characterization of Scottish-Irish type (epsilon gamma delta beta)zero thalassemia.
The DNA deletion associated with an example of (epsilon gamma delta beta)zero thalassemia (Scottish-Irish type) was characterized.
The deletion is approximately 205 kb in length and involves the epsilon, G ga... | C15 |
2,597 | 870 | Hydroxychloroquine is effective therapy for control of cutaneous sarcoidal granulomas.
Cutaneous sarcoidosis often responds poorly to topical and intralesional corticosteroids but may respond to moderate to high doses of oral corticosteroids.
To avoid the use of systemic corticosteroids, we treated 17 patients with c... | C15 |
2,598 | 6,349 | Body fluid spaces and blood pressure in hemodialysis patients during amelioration of anemia with erythropoietin.
Blood pressure (BP) may increase in hemodialysis patients during treatment of anemia with recombinant human erythropoietin (r-HuEPO).
Since fluid volume is a determinant of BP in dialysis patients, changes... | C15 |
2,599 | 5,341 | Coccidioidomycosis during human immunodeficiency virus infection. A review of 77 patients.
Through a retrospective review, we identified 77 previously unreported cases of coccidioidomycosis during HIV infection.
Patients were classified into 1 of 6 categories based on their primary clinical presentation: 20 had focal... | C15 |
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