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10.1210/jc.2013-2350 | Medicine_126 | "Our study indicates women who have PCOS have twice as many hospital admissions as women without the condition. | Some women with PCOS and a eumenorrheic menstrual history may still experience anovulation, and a midluteal serum progesterone may be helpful as an additional screening test. | "PCOS has profound implications for a women's reproductive health as well as her long-term risk of chronic illness," said one of the study's authors, Roger Hart, MD, MRCOG, FRANZCOG, CREI, of the University of Western Australia and Fertility Specialists of Western Australia, both in Perth, Australia. "Our study indicat... | Nevertheless, lifetime fecundity in Swedish women with PCOS was similar to controls, and almost three-fourths of women with PCOS conceived spontaneously . Some women with PCOS and a eumenorrheic menstrual history may still experience anovulation, and a midluteal serum progesterone may be helpful as an additional screen... | [2.0, 1.0, 2.0] | Medicine | train | 1.666667 | news | http://www.healthcanal.com/female-reproductive/59582-women-diagnosed-with-pcos-twice-as-likely-to-be-hospitalized.html |
10.1007/s00127-012-0548-z | Medicine_127 | Unlike PMS, which most women of reproductive age will experience to a greater or lesser degree, the symptoms of PMDD are so intense they disrupt everything in the sufferer's life, from relationships to work. | These findings suggest that clinicians treating women with PMDD should assess and be vigilant for signs of suicidal behavior, and that clinicians might evaluate and treat the premenstrual symptoms of women who express suicidal ideation, plans, or attempts. | Until next month, when it all begins again. Unlike PMS, which most women of reproductive age will experience to a greater or lesser degree, the symptoms of PMDD are so intense they disrupt everything in the sufferer's life, from relationships to work. Of the 12 women with PMDD I spoke to, all had at some point adjusted... | In conclusion, this study is the first to demonstrate a strong, independent association between PMDD and suicidal ideation, plans, and attempts among a nationally representative sample of women. These findings suggest that clinicians treating women with PMDD should assess and be vigilant for signs of suicidal behavior,... | [2.0, 4.0, 4.0, 2.0, 3.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=38040647815&p=1pl&v=1&x=vWjKUbywlMMZxsOdDZ84HQ |
10.1080/08870446.2013.818674 | Medicine_128 | Self-efficacy and support
The result: support from their partners is helpful to smokers who wish to stop and it increases their chances of success, provided that they have developed skills of their own that help them to abstain. | Thus, self-regulation alone might not suffice but smokers might be in need of both high self-regulation skills and high levels of received social support from their spouses. | Self-efficacy and support
The result: support from their partners is helpful to smokers who wish to stop and it increases their chances of success, provided that they have developed skills of their own that help them to abstain. Such support could involve their partner reminding them of their plan to quit as well as e... | Alternatively, the synergistic effects of social support and individual regulation variables as for example found by for the association of attitudes and intentions may also appear in the context of smoking cessation. Thus, self-regulation alone might not suffice but smokers might be in need of both high self-regulatio... | [4.0, 4.0, 5.0, 5.0, 4.0] | Medicine | train | 4.4 | news | http://www.healthcanal.com/substance-abuse/41119-rauchstopp-zu-zweit.html |
10.1111/cdev.12250 | Medicine_129 | The pseudomature behaviors evolved into larger problems and the status of once cool individuals dropped: "The adolescent who comes to depend upon pseudomature behavior to gain peer status may gradually need to shift, for example, from minor forms of delinquency, such as vandalism and shoplifting, to more serious acts o... | These analyses indicate numerous simple correlations between early adolescent pseudomature behaviors (i.e., minor deviance, selection of attractive peers, precocious romantic behavior), and initial (but not later) levels of popularity, and between these early pseudomature behaviors and later negative outcomes, all of w... | In fact, just the opposite happened. The pseudomature behaviors evolved into larger problems and the status of once cool individuals dropped: "The adolescent who comes to depend upon pseudomature behavior to gain peer status may gradually need to shift, for example, from minor forms of delinquency, such as vandalism an... | For descriptive purposes, Table 1 also presents simple correlations among all primary constructs examined in the study. These analyses indicate numerous simple correlations between early adolescent pseudomature behaviors (i.e., minor deviance, selection of attractive peers, precocious romantic behavior), and initial (b... | [4.0, 2.0, 2.0, 4.0, 4.0] | Medicine | train | 3.2 | news | http://www.businessinsider.com/being-popular-in-high-school-leads-to-problems-in-adulthood-2014-6 |
10.1098/rsos.171474 | Medicine_13 | The title lays it out plainly: "Violent video game engagement is not associated with adolescents' aggressive behaviour." | Despite the null findings identified in the present study, history gives us reason to suspect the idea that violent video games drives aggressive behaviour will remain an unsettled question for parents, pundits and policy-makers. | The title lays it out plainly: "Violent video game engagement is not associated with adolescents' aggressive behaviour." Their top-line finding is that their study "did not support the position that violent gaming relates to aggressive behaviour." This contradicts the consensus hammered out by an American Psychological... | Until such findings are confirmed, however, we strongly would caution about drawing impulsive, thoughtless or potentially stigmatizing conclusions about members of such groups . Despite the null findings identified in the present study, history gives us reason to suspect the idea that violent video games drives aggress... | [3.0, 1.0, 5.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=38538076628&p=1pl&v=1&x=7Ko5INusmGh9TtCxVKqTtA |
10.1016/j.jpeds.2017.10.028 | Medicine_130 | The study found that spanked kids tended to have higher odds of being violent toward their dating partners, researchers said. | There was no significant association by sex (c 2 [3] = 3.52, P = .32), ethnicity (c 2 = 15.86, P =.07), or parental education (c 2 = 9.38, P = .40) differences in terms of corporal punishment (Table II) . | The study found that spanked kids tended to have higher odds of being violent toward their dating partners, researchers said. "While we can't say that spanking causes later violence, it follows that if a kid learns that physical punishment is a way to solve conflict, he/she may carry that over into conflicts with later... | Nineteen percent of participants (n = 134) reported physical perpetration of dating violence, and more than one-half (68%) reported experiencing corporal punishment as children (n = 498, mean = 1.07, SD = 0.96). There was no significant association by sex (c 2 [3] = 3.52, P = .32), ethnicity (c 2 = 15.86, P =.07), or p... | [1.0, 2.0, 2.0, 1.0, 2.0] | Medicine | train | 1.6 | news | http://ct.moreover.com/?a=32686504555&p=1pl&v=1&x=J_KXigEKTcXYUPzjI0fyuQ |
10.1001/jamapsychiatry.2015.0500 | Medicine_131 | It's also not necessarily strange that these drugs were used in cases where the child had no mental health diagnosis, though it could suggest overuse. | However, only a minority filled 1 or more antipsychotic prescriptions from a child and adolescent psychiatrist (29.3% of young children, 39.2% of older children, 39.2% of adolescents, and 14.2% of young adults in 2010). | But because of the unknown risks that come with flooding a maturing brain with these drugs, they should be utilized only when it's absolutely necessary. It's also not necessarily strange that these drugs were used in cases where the child had no mental health diagnosis, though it could suggest overuse. The authors hope... | Most young people treated with antipsychotics in each age group filled 1 or more antipsychotic prescriptions that were written by a psychiatrist (57.9% of young children, 71.9% of older children, 77.9% of adolescents, and 70.4% of young adults in 2010) ( Table 2) . However, only a minority filled 1 or more antipsychoti... | [2.0, 3.0, 5.0, 3.0] | Medicine | train | 3.25 | news | http://www.medicaldaily.com/antipsychotics-are-being-given-kids-temporary-behavioral-problems-adhd-341188 |
10.1177/0956797617692041 | Medicine_132 | But data from two additional experiments indicate that this unintended increase in consumption can be dampened somewhat by requiring people to get the refills themselves. | Thus, the increased consumption observed in the refill condition was driven by consumption of large drinksthe only drink size that included free refills. | This may have happened, the researchers surmise, because consumers wanted to get their "money's worth" - that is, they consumed more of the refill since they had already paid for it. But data from two additional experiments indicate that this unintended increase in consumption can be dampened somewhat by requiring peop... | For the large drink, however, the participants consumed 44.0% more calories in the refill condition than in the typical-portion condition (refill: M = 208.05 kcal, SD = 106.69; typical portion: M = 144.51 kcal, SD = 50.43), t(111) = 4.10, p < .001, d = 0.77. Thus, the increased consumption observed in the refill condit... | [5.0, 2.0, 4.0, 1.0, 2.0] | Medicine | train | 2 | news | http://healthmedicinet.com/news/some-strategies-to-limit-sugary-drinks-may-backfire/ |
10.1016/j.socscimed.2018.10.008 | Medicine_133 | Furthermore, women whose births had complications were 174 percent more likely to experience PND compared to those women who had no complications. | We found the odds of PND increased by 71-79% when male infants were born compared to female infants. | Specifically, University of Kent investigators discovered that women who give birth to males are 71-79 percent more likely to develop PND. Furthermore, women whose births had complications were 174 percent more likely to experience PND compared to those women who had no complications. As a result of their findings, inv... | We found the odds of PND increased by 71-79% when male infants were born compared to female infants. The occurrence of birth complications increased the odds of PND by 174% compared to having no complications. Testing for interaction effects found that, while always at increased risk of PND, women with a tendency towar... | [2.0, 2.0, 2.0, 3.0, 2.0] | Medicine | train | 2.2 | news | http://ct.moreover.com/?a=37619913738&p=1pl&v=1&x=c7HTLKfs7Zb4iDFM2zXdrQ |
10.1016/j.socscimed.2018.10.008 | Medicine_134 | Furthermore, women whose births had complications were 174 percent more likely to experience PND compared to those women who had no complications. | We did not find much evidence for the additive effects of birth complications with other PND risk factors in our sample (low SES, low social support, and a history of depression, anxiety, and stress) as anticipated. | Specifically, University of Kent investigators discovered that women who give birth to males are 71-79 percent more likely to develop PND. Furthermore, women whose births had complications were 174 percent more likely to experience PND compared to those women who had no complications. As a result of their findings, inv... | Irrespective of whether post-birth infections are experienced, birth complications are likely to be stressful for women, particularly if they resulted in emergency procedures being undertaken. We did not find much evidence for the additive effects of birth complications with other PND risk factors in our sample (low SE... | [3.0, 2.0, 3.0, 3.0, 3.0] | Medicine | train | 2.8 | news | http://ct.moreover.com/?a=37619913738&p=1pl&v=1&x=c7HTLKfs7Zb4iDFM2zXdrQ |
10.1186/s12916-017-0986-2 | Medicine_135 | "This study highlights how common postoperative complications are among older adults undergoing elective surgery, and the importance of geriatric syndromes, including frailty, in identifying older adults who may be at risk," she said. | One study found that, while frail patients with postoperative complications had prolonged hospitalizations (P < 0.001), those without postoperative complications did not (P = 0.19) . | "Older adults are a diverse group of patients whose risk of postoperative complications is not solely defined by their age, co-morbidities (multiple health problems) or the type of surgical procedure they receive," Watt said. "This study highlights how common postoperative complications are among older adults undergoin... | Among six studies that investigated frailty as a prognostic factor for prolonged hospitalization, there was a significant association identified in four studies . One study found that, while frail patients with postoperative complications had prolonged hospitalizations (P < 0.001), those without postoperative complicat... | [3.0, 3.0, 2.0, 2.0, 1.0] | Medicine | train | 2.2 | news | http://ct.moreover.com/?a=33000673455&p=1pl&v=1&x=ZUA80X35mG1U_VnPyqM0hw |
10.1016/j.jalz.2018.06.2856 | Medicine_136 | "This paper is pointing to a new area of opportunity," he said. | Subsequent studies of ophthalmic diseases in relation to AD and dementia may provide important insights into shared pathological pathways, thus enabling better techniques to prevent and treat. | The researchers said several factors suggest the effects they uncovered were specific to ophthalmic conditions and not merely age-related phenomenon. "This paper is pointing to a new area of opportunity," he said. Note: material may have been edited for length and content. | In summary, glaucoma, AMD, and DR are associated with increased AD risk, whereas cataract is not. Subsequent studies of ophthalmic diseases in relation to AD and dementia may provide important insights into shared pathological pathways, thus enabling better techniques to prevent and treat. Supplementary data related to... | [3.0, 5.0, 1.0, 3.0, 3.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34765487148&p=1pl&v=1&x=ufEabPDBICA34OF2ZCudfA |
10.1038/nature13850 | Medicine_137 | According to the study, "the unexpected morphology suggests that the magnetic field's role during the accretion of a T Tauri star is more complex than the current theoretical understanding," and that magnetic fields are important in forming a planetary system like our own. | Misalignment of the field lines with the rotation axis can help overcome magnetic braking to create a centrifugally supported disk at the 0 AU scale . | These CARMA observations found the first detection of the magnetic field morphology in a T Tauri star disk. According to the study, "the unexpected morphology suggests that the magnetic field's role during the accretion of a T Tauri star is more complex than the current theoretical understanding," and that magnetic fie... | At the 1,000 AU scale, structured magnetic fields are observed around young, low-mass protostars , but the fields appear to be randomly aligned with respect to the inferred disk . Misalignment of the field lines with the rotation axis can help overcome magnetic braking to create a centrifugally supported disk at the 0 ... | [4.0, 1.0, 1.0, 3.0, 2.0] | Medicine | train | 2.2 | news | http://www.futurity.org/stars-magnetic-field-803342/ |
10.1001/jamapediatrics.2013.4951 | Medicine_138 | A Genetic Risk for Big Appetites
The importance of catching these signs could become greater if the child is already genetically predisposed to a large appetite. | Similar patterns are to be expected in the wider population; therefore, this study corroborates the hypothesis that a hearty appetite in infancy is a risk factor for faster weight gain. | This behavior could put her at risk of gaining weight faster than is good for her." A Genetic Risk for Big Appetites
The importance of catching these signs could become greater if the child is already genetically predisposed to a large appetite. "As expected, we found that children with a higher PRS score were likely ... | 25 Our findings indicate that within the same family the sibling with the higher appetite grows faster than the sibling with the lower appetite. Similar patterns are to be expected in the wider population; therefore, this study corroborates the hypothesis that a hearty appetite in infancy is a risk factor for faster we... | [4.0, 3.0, 4.0] | Medicine | train | 3.666667 | news | http://www.medicaldaily.com/controlling-appetite-may-be-best-bet-curbing-childhood-obesity-269480 |
10.1152/ajpregu.00204.2013 | Medicine_139 | This study, the first to look at the effects of CO on the placenta in mice, found that exposing the animals to inhalable CO increased blood flow and vascular growth in the developing placenta, created more, bigger, and stronger connections to the mother's uterus, a process that provides more oxygen and nutrients to the... | We demonstrated that the ratio of placental total VEGFR1 to VEGF was significantly reduced in both chronic and acutely exposed animals, indicating a possible mechanism for the placental vessel changes noted. | Although toxic at high levels, low levels of CO are produced naturally by the body and have positive effects. This study, the first to look at the effects of CO on the placenta in mice, found that exposing the animals to inhalable CO increased blood flow and vascular growth in the developing placenta, created more, big... | Perhaps the CO effect is more strongly related to a decreased sFLT1 release, thus increasing the VEGF bioavailability. We demonstrated that the ratio of placental total VEGFR1 to VEGF was significantly reduced in both chronic and acutely exposed animals, indicating a possible mechanism for the placental vessel changes ... | [2.0, 2.0, 4.0, 2.0, 2.0] | Medicine | train | 2.4 | news | http://www.sciencedaily.com/releases/2013/09/130919154253.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1001/jama.2013.285112 | Medicine_14 | We have to attack the problem with renewed commitment, utilizing both the interventions documented to reduce smoking and perhaps new regulatory approaches. | In women, life expectancy at age 40 years increased 5.4 years (from 37.4 to 42.7 years), but without tobacco control, it would have been projected to increase by only 3.8 years (from 37.3 to 41.2 years). | It is seen by many as a pivotal moment in American public health and as the opening salvo in an ongoing effort to convince people to stop smoking. We have to attack the problem with renewed commitment, utilizing both the interventions documented to reduce smoking and perhaps new regulatory approaches. "The job of tobac... | Hence, 2.3 years (CR, 1.8-2.5) or 30% (CR, 23%-32%) of improved life expectancy for men is projected to be associated with tobacco control. In women, life expectancy at age 40 years increased 5.4 years (from 37.4 to 42.7 years), but without tobacco control, it would have been projected to increase by only 3.8 years (fr... | [1.0, 3.0, 2.0, 1.0] | Medicine | train | 1.75 | news | http://www.healthcanal.com/public-health-safety/46414-millions-of-lives-saved-since-surgeon-general-s-tobacco-warning-50-years-ago.html |
10.1001/jamapsychiatry.2018.1941 | Medicine_142 | In the brains of those living with depressive problems, they discovered a strong connection between the dorsolateral prefrontal cortex (associated with short-term memory), the precuneus (associated with the self), and the lateral orbitofrontal cortex (associated with negative emotion). | In particular, in this subgroup of 92, correlations were found for the Depressive Problems score for 6 links involving the lateral orbitofrontal cortex (to the left middle frontal gyrus: r = 0.410; P < .001; left supramarginal gyrus: r =0 . | This research could lead to better sleep quality for people with depression, and opens up the possibility of new targeted treatments. In the brains of those living with depressive problems, they discovered a strong connection between the dorsolateral prefrontal cortex (associated with short-term memory), the precuneus ... | This was supported by the finding of correlations between the depressive score and many functional connectivities involving the lateral orbitofrontal cortex when only this subgroup of 92 were included. In particular, in this subgroup of 92, correlations were found for the Depressive Problems score for 6 links involving... | [2.0, 4.0, 3.0, 4.0, 3.0] | Medicine | train | 3.2 | news | https://www.futurity.org/depression-sleep-problems-insomnia-1821432-2/ |
10.1038/s41598-018-30980-y | Medicine_143 | "This study demonstrates that napping is beneficial to memory processing," they point out. | This supports an interplay between the nap and subsequent overnight sleep in the consolidation of memories in young children. | As in observations by others, "both a nap and subsequent overnight sleep was necessary to observe performance benefits." "This study demonstrates that napping is beneficial to memory processing," they point out. "Given the importance of socio-emotional learning in preschool naps averaging 70 minutes may support the cur... | A significant benefit of napping was observed only when changes across the entire 24-hour period were considered. This supports an interplay between the nap and subsequent overnight sleep in the consolidation of memories in young children. A day of continuous wake led to significant forgetting, particularly for the hab... | [5.0, 5.0, 5.0, 2.0, 4.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1073/pnas.1504869112 | Medicine_144 | The study will be useful in guiding scientists working to predict the trajectory of carbon storage as atmospheric concentrations rise, and it may help explain recent observations that the carbon storage capacity of tropical forests is declining. | Notwithstanding, our results indicate that, due to their unique attributes, lianas have the potential to severely reduce both the carbon sink potential and long-term carbon storage capacity of tropical forests. | Extrapolating their results to tropical forests as a whole, the team calculated that lianas could potentially reduce long-term storage of carbon in tropical forests by one-third or more. The study will be useful in guiding scientists working to predict the trajectory of carbon storage as atmospheric concentrations rise... | Longer-term data are needed to assess whether this initial difference in carbon sink potential persists over time. Notwithstanding, our results indicate that, due to their unique attributes, lianas have the potential to severely reduce both the carbon sink potential and long-term carbon storage capacity of tropical for... | [3.0, 2.0, 2.0] | Medicine | train | 2.333333 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/PUyOGba13Ho/ |
10.1001/jamapsychiatry.2018.1941 | Medicine_146 | An analysis of the records of 9,735 people living with depressive problems found that there was increased activity between these brain regions in people who also reported disrupted sleep patterns, and that's a crucial discovery in our understanding of these conditions. | Further, the mediating effects of the 39 functional connectivities of the effects of the sleep quality on the depressive problems had much lower significance (3.4% of the total effect size, =0.016, p=0.0095, Fig. | Researchers found a strong connection between the dorsolateral prefrontal cortex (responsible for short-term memory), the precuneus (linked with ideas of the self) and the lateral orbitofrontal cortex (associated with negative emotions). An analysis of the records of 9,735 people living with depressive problems found t... | In the reverse direction, only 2 links significantly mediated effects of sleep quality on depressive problems with FDR correction. Further, the mediating effects of the 39 functional connectivities of the effects of the sleep quality on the depressive problems had much lower significance (3.4% of the total effect size,... | [3.0, 2.0, 1.0, 2.0, 3.0] | Medicine | train | 2.2 | news | http://ct.moreover.com/?a=34644678837&p=1pl&v=1&x=NPMHP58RsDT7VzhGCx19YA |
10.1038/s41467-018-05709-0 | Medicine_147 | In their experiments, the pharmacologists were able to show that it not only suppresses acute itch, but is also effective against chronic itch. | Our results indicate that drugs targeting α2 and α3GABA A receptors are well-suited to alleviate itch, including nonhistaminergic chronic itch for which currently no approved treatment exists. | In their experiments, the pharmacologists were able to show that it not only suppresses acute itch, but is also effective against chronic itch. Mice that were administered with the drug scratched themselves less often, and their skin changes healed significantly quicker than in animals that were given a placebo. The sa... | Systemic treatment with an α2/α3GABA A receptor selective modulator alleviates also chronic itch in a mouse model of atopic dermatitis and in dogs sensitized to house dust mites, without inducing sedation, motor dysfunction, or loss of antipruritic activity after prolonged treatment. Our results indicate that drugs tar... | [3.0, 4.0, 5.0, 3.0, 5.0] | Medicine | train | 4 | news | http://ct.moreover.com/?a=34818663460&p=1pl&v=1&x=L-gib_N5MhiGEP62jfuz-g |
10.1016/j.mayocp.2014.07.004 | Medicine_148 | The investigators found that smokers who used a combination of specialist behavioral support and medication in their quit attempts reported higher levels of urges to smoke than did smokers who tried to quit unaided. | After adjusting for this confounder, we found that smokers who use a combination of specialist behavioral support and medication in their quit attempts had almost 3 times the odds of success than did those who used neither medication nor behavioral support. | A total of 23% reported not smoking at the end of the six-month period. The investigators found that smokers who used a combination of specialist behavioral support and medication in their quit attempts reported higher levels of urges to smoke than did smokers who tried to quit unaided. After adjusting for this, they f... | 8 Still, smokers who used medication and behavioral support reported higher levels of urges to smoke than did smokers who tried to quit unaided. After adjusting for this confounder, we found that smokers who use a combination of specialist behavioral support and medication in their quit attempts had almost 3 times the ... | [1.0, 3.0, 3.0, 5.0] | Medicine | train | 3 | news | http://www.sciencedaily.com/releases/2014/10/141008083514.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1001/jamapsychiatry.2015.0500 | Medicine_149 | This study, which may be the broadest look yet at use of antipsychotics in children, found that most children had not been diagnosed with a mental disorder before being given antipsychotics. | However, only a minority filled 1 or more antipsychotic prescriptions from a child and adolescent psychiatrist (29.3% of young children, 39.2% of older children, 39.2% of adolescents, and 14.2% of young adults in 2010). | Boys were more likely to be given the medications. This study, which may be the broadest look yet at use of antipsychotics in children, found that most children had not been diagnosed with a mental disorder before being given antipsychotics. ADHD was the most common diagnosis, applied to 52.5 percent of young children,... | Most young people treated with antipsychotics in each age group filled 1 or more antipsychotic prescriptions that were written by a psychiatrist (57.9% of young children, 71.9% of older children, 77.9% of adolescents, and 70.4% of young adults in 2010) ( Table 2) . However, only a minority filled 1 or more antipsychoti... | [1.0, 5.0, 1.0, 3.0, 3.0] | Medicine | train | 2 | news | http://www.npr.org/sections/health-shots/2015/07/01/418935734/antipsychotics-too-often-prescribed-for-aggression-in-children |
10.1038/s41598-018-20760-z | Medicine_15 | An AFM height image recorded 1 hour after SDS injection showed random unevenness on the surface, which indicates random adsorption of SDS molecules on the graphene surface. | This result indicates spontaneous random adsorption of the SDS molecules onto the graphene surface after the SDS solution injection. | The development of a reliable method that enables the perfect alignment of molecules or molecular assemblies on a graphene surface may lead the way to tune the electric properties of graphene, and to improve the performance of graphene-based electronic devices. An AFM height image recorded 1 hour after SDS injection sh... | The height of the graphene increased by ~2.5 nm overall, and aggregates of various size appeared (see Supplementary Fig. This result indicates spontaneous random adsorption of the SDS molecules onto the graphene surface after the SDS solution injection. The subsequent intense scanning with a large force between the tip... | [4.0, 5.0, 4.0, 5.0] | Medicine | train | 4.5 | news | http://ct.moreover.com/?a=33624582612&p=1pl&v=1&x=OROGVuUGDgkWIep8DYDL5w |
10.1210/jc.2013-2350 | Medicine_150 | Women diagnosed with PCOS were hospitalized more often for mental health disorders such as depression, stress and anxiety than other study participants. | Evaluation of women with PCOS should exclude alternate androgen-excess disorders and risk factors for endometrial cancer, mood disorders, obstructive sleep apnea, diabetes, and cardiovascular disease. | Women who had PCOS also had a higher rate of endometrial cancer, or cancer of the lining of the uterus. Women diagnosed with PCOS were hospitalized more often for mental health disorders such as depression, stress and anxiety than other study participants. A PCOS diagnosis also was associated with a higher risk of late... | We suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). Evaluation of women with PCOS should exclude alternate androgen-excess disorders and risk factors for endometrial cancer, mood disorders, obstructive sl... | [2.0, 3.0, 2.0, 3.0, 2.0] | Medicine | train | 2.4 | news | http://www.healthcanal.com/female-reproductive/59582-women-diagnosed-with-pcos-twice-as-likely-to-be-hospitalized.html |
10.1111/cdep.12038 | Medicine_151 | In fact, children who are spanked tend to become more aggressive over time, not less. | Spanking alone does not teach children why their behavior was wrong or what they should do instead . | Overwhelming evidence
It's actually quite stunning that any parent today would use corporal punishment when the evidence overwhelmingly shows that this form of discipline is harmful, not helpful, to a child's development. In fact, children who are spanked tend to become more aggressive over time, not less. In addition... | It is difficult to imagine that a parent would be able to meet all these criteria when administering spanking; indeed, it would likely be both inadvisable and bordering on abusive if parents spanked children following every instance of a given misbehavior. Spanking alone does not teach children why their behavior was w... | [2.0, 3.0, 3.0, 3.0] | Medicine | train | 2.75 | news | http://www.minnpost.com/second-opinion/2014/04/parents-often-spank-out-anger-and-trival-reasons-real-time-study-finds |
10.1038/s41467-018-05229-x | Medicine_152 | In a bulk solid, Wannier-Stark localization can only be maintained for an extremely short period of time, shorter than a single oscillation of infrared light. | Instead, they will be further excited to the energetically higher conduction and the lower valence bands, respectively, which will actually reduce their contribution to the bleaching of the optical absorption in the frequency range that is investigated here. | "This fundamental effect was predicted more than 80 years ago. In a bulk solid, Wannier-Stark localization can only be maintained for an extremely short period of time, shorter than a single oscillation of infrared light. Using the ultrafast laser systems at the University of Konstanz, Wannier-Stark localization has no... | In the experiment, the electron and hole occupations generated by an intense THz field will not stay in the lowest conduction and the highest valence bands. Instead, they will be further excited to the energetically higher conduction and the lower valence bands, respectively, which will actually reduce their contributi... | [2.0, 2.0, 1.0, 1.0] | Medicine | train | 1.5 | news | http://ct.moreover.com/?a=34669971079&p=1pl&v=1&x=vdqBVutlRrBG6NrsU9ADLw |
10.1377/hlthaff.2012.1030 | Medicine_154 | "The scale of this variation signals potential quality issues that should be quite alarming to women, clinicians, hospitals and policymakers," she added.Cesarean delivery is the most common surgery in the United States, performed on 1.67 million women each year. | 43 State or federal public health agencies or licensing and accreditation boards can increase transparency and information availability through public reporting requirements for hospital cesarean delivery rates among lower-risk women, for example. | The variations we uncovered were striking in their magnitude, and were not explained by hospital size, geographic location, or teaching status," study lead author Katy Kozhimannil, an assistant professor at the university's School of Public Health, said in a school news release. "The scale of this variation signals pot... | 42 ▸ENHANCE PATIENT-CENTERED DECISION MAKING FOR MATERNITY CARE THROUGH PUBLIC REPORTING: Some pregnant women may face limited care options and lack full information on risks, benefits, and alternatives associated with medical care at the time of childbirth. 43 State or federal public health agencies or licensing and a... | [2.0, 1.0, 1.0, 4.0, 1.0] | Medicine | train | 1.8 | news | http://www.webmd.com/baby/news/20130304/c-section-rates-vary-widely-at-us-hospitals |
10.1038/s41598-018-30980-y | Medicine_155 | The researchers say another highlight of their work is finding that naps do contribute to emotion processing in preschool children, which is consistent with parents' and early childhood teachers' observations, though this benefit in emotional memory is delayed, say Spencer and colleagues. | predict ΔRecall 24-hr (B = −0.005, p = 0.983), nor was there a significant relationship between ΔRecall 24hr and the average SWA across both the nap and the overnight sleep bouts (B = −0.081, p = 0.936). | This supports an interplay between the nap and subsequent overnight sleep in the consolidation of memories in young children." The researchers say another highlight of their work is finding that naps do contribute to emotion processing in preschool children, which is consistent with parents' and early childhood teacher... | When children napped, it took them longer to Table 2 . predict ΔRecall 24-hr (B = −0.005, p = 0.983), nor was there a significant relationship between ΔRecall 24hr and the average SWA across both the nap and the overnight sleep bouts (B = −0.081, p = 0.936). In light of the reduced accuracy across the nap predicting im... | [1.0, 2.0, 2.0] | Medicine | train | 1.666667 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1038/s41598-018-29793-w | Medicine_157 | The discovery surprised even the longtime cold researchers who made it. | Thus, microbiota at the time of infection may influence subsequent rhinovirus viral load. | The compositions also were found to correlate with viral load - the amount of cold virus inside the body. The discovery surprised even the longtime cold researchers who made it. "The first surprise was that you can kind of identify these different buckets that people kind of fit into, and then the fact that the buckets... | Subjects with Ps/Mix cluster had significantly lower viral load than those subjects with Mor or Staph predominant microbiota types (Fig. Thus, microbiota at the time of infection may influence subsequent rhinovirus viral load. The results also suggest that high inflammatory response does not lead to low viral load as t... | [1.0, 1.0, 3.0, 3.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=37216978560&p=1pl&v=1&x=LVY7mDoQyN4rZ-ttzNExlg |
10.1038/s41467-019-08382-z | Medicine_158 | These interactions help Hel2 identify flaws in protein formation. | This indicates reduced RNA-binding efficiency, particularly for Hel2 . | This clears the way for further proteins to be produced. These interactions help Hel2 identify flaws in protein formation. When researchers removed the parts of Hel2 in direct contact, this prevented the destruction of faulty proteins, showing that these contacts are important for the mechanism. | Despite this, total recovery of RNA in association with the mutant proteins was not increased in comparison to wild-type Hel2 ( Supplementary Tables 5-7) . This indicates reduced RNA-binding efficiency, particularly for Hel2 . In CRAC analyses, both truncation mutants showed substantially altered rRNA recovery, with re... | [2.0, 4.0, 3.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=38442592628&p=1pl&v=1&x=6qnjJlZN_F0RgmqDHnl0dA |
10.1016/j.scitotenv.2019.04.266 | Medicine_159 | "Here again, a good understanding of wildlife consumer demography, economic status, and motivations is essential to the design of effective policy with limited un-intended consequences on more vulnerable communities," the authors write. | On a policy level, these aspects can appear as competing priorities between wildlife conservation, sustainable use, food safety, food security, and cultural aspects. | From questionnaires administered to both seller and buyers, the team found that most consumers bought bushmeat not because they needed the protein, but because they preferred the taste of it to livestock or they saw it as a healthier choice. "Here again, a good understanding of wildlife consumer demography, economic st... | Therefore, it is clear that the hunting, trade, and consumption of wildlife are concurrently concerns for zoonotic disease transmission, significant sources of nutrients and/or livelihood for some communities, and major causes of biodiversity loss. On a policy level, these aspects can appear as competing priorities bet... | [2.0, 1.0, 3.0, 1.0] | Medicine | train | 1.75 | news | http://ct.moreover.com/?a=39231575932&p=1pl&v=1&x=ugOkJg6MHSJ-5jXepqCzLA |
10.1093/jee/tou026 | Medicine_16 | After removing the bark from one of the trees, he found evidence that at least three generations of emerald ash borer larvae had used the tree, and he saw several live larvae that were actively feeding. | Removal of bark from one of these trees yielded evidence of three generations of usage by emerald ash borer, a dead adult, and live emerald ash borer larvae. | Fortunately, its damage has been limited to ash trees -- or so we thought. After removing the bark from one of the trees, he found evidence that at least three generations of emerald ash borer larvae had used the tree, and he saw several live larvae that were actively feeding. In addition, he found a dead adult that ha... | In total, 4 of the 20 mature white fringetrees I examined over this period showed symptoms of emerald ash borer attack. Removal of bark from one of these trees yielded evidence of three generations of usage by emerald ash borer, a dead adult, and live emerald ash borer larvae. Some of the other trees I examined may hav... | [3.0, 5.0, 5.0, 5.0] | Medicine | train | 4.5 | news | http://www.sciencedaily.com/releases/2015/01/150115102827.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1186/s40168-015-0071-z | Medicine_160 | The authors found that the intestinal tracts of infants fed by non-secretor mothers are delayed in establishing a bifidobacteria-dominated microbiota. | At first glance, it appeared as if there were no species-level differences in the bifidobacterial populations of secretorfed and non-secretor-fed infants ( Figure 11 ). | The study found that, on average, Bifidobacterium were established earlier and more frequently in infants fed by women with an active copy of the gene, the secretors, than without one, the non-secretors. The authors found that the intestinal tracts of infants fed by non-secretor mothers are delayed in establishing a bi... | In addition, of the two isolates obtained from non-secretor-fed infants that could grow on 2FL, one was a Bifidobacterium dentium strain, a species adapted to oral niches . At first glance, it appeared as if there were no species-level differences in the bifidobacterial populations of secretorfed and non-secretor-fed i... | [2.0, 5.0, 2.0, 4.0, 4.0] | Medicine | train | 2 | news | http://www.sciencedaily.com/releases/2015/04/150409143035.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1126/science.1252496 | Medicine_162 | "These particles are so precious. | The observed impact density of nonterrestrial materials on the foils is 0.8 cm −2 , and thus the fraction of impacts of interplanetary origin is estimated to be 0.17/0.8 = 0.2. | While the samples are suspected to be from beyond the solar system, he says, potential confirmation of their origin must come from subsequent tests that will ultimately destroy some of the particles. "These particles are so precious. We have to think very carefully about what we do with each particle." | Although the trajectories of the four foil interstellar candidates are unknown, statistical arguments based on trajectories still apply. The observed impact density of nonterrestrial materials on the foils is 0.8 cm −2 , and thus the fraction of impacts of interplanetary origin is estimated to be 0.17/0.8 = 0.2. This v... | [1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://www.nanowerk.com/news2/space/newsid=37140.php |
10.1111/1365-2656.12871 | Medicine_163 | "The effect of RHDV disease virus on rabbits is enhanced by previous infection with MYXV virus. | These suggestions are speculative, and not mutually exclusive, but could be a starting point for examining why rabbits challenged with MYXV have survival rates similar to susceptible animals. | It is no longer a case of which disease is a better control agent, because their effectiveness is intrinsically linked." "The effect of RHDV disease virus on rabbits is enhanced by previous infection with MYXV virus. Survival rates were lowest for rabbits which survived MYXV infection and then were exposed to RHDV dise... | Another possible explanation is that exposure to MYXV compromises the health of rabbits in such a way that it reduces the survival of individuals subsequently infected by RHDV. These suggestions are speculative, and not mutually exclusive, but could be a starting point for examining why rabbits challenged with MYXV hav... | [2.0, 4.0, 3.0, 3.0, 3.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=34506942217&p=1pl&v=1&x=OCP5j07SbNKK_Tx7JPH1Dw |
10.1038/s41598-018-29793-w | Medicine_164 | Each nasal microbiota type had a characteristic inflammatory response and viral load profile. | Our study is aligned with the previous findings suggesting that the microbiota in the nose has seasonal variation. | The study team found that the baseline nasal microbiota samples divided into six types named after predominant bacterial genera: (1) Staphylococcus, (2) Corynebacterium/Alloiococcus, (3) Moraxella, (4) Haemophilus, (5) Pseudomonadaceae/Mixed, and (6) Mixed. Each nasal microbiota type had a characteristic inflammatory r... | The microbiota clusters appear to associate with different inflammatory response, viral titer, and symptom severity profiles in rhinovirus infection. Our study is aligned with the previous findings suggesting that the microbiota in the nose has seasonal variation. We further found that rhinovirus infection did not have... | [3.0, 3.0, 3.0, 2.0] | Medicine | train | 2.75 | news | http://ct.moreover.com/?a=37212363335&p=1pl&v=1&x=sLcdfRtU-o1Jl6n2DiKDzQ |
10.1001/jamapsychiatry.2015.0500 | Medicine_165 | This study, which may be the broadest look yet at use of antipsychotics in children, found that most children had not been diagnosed with a mental disorder before being given antipsychotics. | After several years of increasing rates of antipsychotic treatment of children and adolescents in the United States, the rate of antipsychotic use among children decreased between 2008 and 2010. | Boys were more likely to be given the medications. This study, which may be the broadest look yet at use of antipsychotics in children, found that most children had not been diagnosed with a mental disorder before being given antipsychotics. ADHD was the most common diagnosis, applied to 52.5 percent of young children,... | Fourth, service claims data were available only for a subset of patients. After several years of increasing rates of antipsychotic treatment of children and adolescents in the United States, the rate of antipsychotic use among children decreased between 2008 and 2010. In view of evidence of widespread antipsychotic pre... | [3.0, 2.0, 2.0] | Medicine | train | 2.333333 | news | http://www.npr.org/sections/health-shots/2015/07/01/418935734/antipsychotics-too-often-prescribed-for-aggression-in-children |
10.1038/s41467-018-07557-4 | Medicine_166 | There's No Silver Lining
To make matters worse, the study also notes that these drastic changes will still happen even if the world decreases its carbon emission significantly. | With respect to the decades following 2050, however, attainment of the goals of the Paris Agreement's climate warming target (i.e., holding global warming to well below 2°C above preindustrial levels and pursuing efforts to limit the temperature increase to 1.5°C) 29 would make a clear difference in terms of potential ... | There's No Silver Lining
To make matters worse, the study also notes that these drastic changes will still happen even if the world decreases its carbon emission significantly. The new findings revealed "an unprecedentedly high spatial resolution" perspective of how permafrost will jeopardize infrastructure. The findi... | This result is congruent with projected changes in the Arctic 1 , and emphasizes the need for adaptation-based policies at community and regional levels in the near future. With respect to the decades following 2050, however, attainment of the goals of the Paris Agreement's climate warming target (i.e., holding global ... | [1.0, 1.0, 2.0] | Medicine | train | 1.333333 | news | http://ct.moreover.com/?a=37967333906&p=1pl&v=1&x=ltio0H7-Rr6r3LuvSX7DEA |
10.1093/chemse/bjt066 | Medicine_167 | In this study, however, cumin - which was rated positively when presented with the label "Indian food" - did not result in a slower reaction time, unlike parmesan cheese, which yield slower reaction times and was rated positively when presented with the "parmesan cheese" label. | Furthermore, we found an impact of labels on intensity ratings for one of the administered odors that goes against our hypothesis. | "We were surprised by this result because we expected reaction times to increase when all four odours were associated with positive labels," says Manescu. In this study, however, cumin - which was rated positively when presented with the label "Indian food" - did not result in a slower reaction time, unlike parmesan ch... | These findings further strengthen the concept that odor perception is influenced by cognitive interpretation. Furthermore, we found an impact of labels on intensity ratings for one of the administered odors that goes against our hypothesis. We found that participants rated geraniol as more intense when it was labeled p... | [2.0, 4.0, 1.0, 4.0] | Medicine | train | 4 | news | http://www.newswise.com/articles/smelling-with-our-eyes-descriptions-affect-odour-perception |
10.1007/s13524-014-0321-x | Medicine_168 | Older parents, between the ages of 35 -- 49, have the strongest happiness gains around the time of birth and stay at a higher level of happiness after becoming parents. | We then analyze the patterns for different socioeconomic groups and parities and show that the changes in subjective well-being over the transition to parenthood are highly consistent with the low and late fertility behavior that has emerged during the second demographic transition: older parents and those with more so... | Those who have children at an older age or who are more educated have a particularly positive response to a first birth. Older parents, between the ages of 35 -- 49, have the strongest happiness gains around the time of birth and stay at a higher level of happiness after becoming parents. Those who become parents in th... | Importantly, we observe that happiness increases before birth, suggesting that the happiness gain around the time of birth may capture not only the effect of the birth but also the complex childbearing process that may involve partnership formation, partnership quality, and increased sexual activity. We then analyze th... | [2.0, 5.0, 3.0, 3.0] | Medicine | train | 3.25 | news | http://www.sciencedaily.com/releases/2014/10/141028082454.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1098/rspb.2013.3172 | Medicine_169 | Bauch said that as this trend continues, people will come to find themselves in a situation where vaccination coverage has declined and populations are more susceptible to disease. | Vaccine scares can have long-term impacts on vaccine coverage, causing depressed coverage even after the perceived vaccine risk has returned to baseline levels. | Although pediatric vaccination is mandatory across most of North America's public school, the researchers report that the number of parents applying for their children to be exempt from vaccination requirements is on the rise. Bauch said that as this trend continues, people will come to find themselves in a situation w... | The social learning rate k can also influence whether the population converges to no vaccine coverage or returns to full vaccine coverage, after a vaccine scare (figure 5). Vaccine scares can have long-term impacts on vaccine coverage, causing depressed coverage even after the perceived vaccine risk has returned to bas... | [3.0, 3.0, 3.0] | Medicine | train | 3 | news | http://www.natureworldnews.com/articles/6038/20140214/vaccine-scares-perpetrate-below-optimal-coverage-spread-infectious-diseases.htm |
10.1210/jc.2013-2350 | Medicine_17 | Researchers analyzing the data found women who were diagnosed with PCOS were more likely to be hospitalized for reasons unrelated to reproductive health or injury than their counterparts. | We suggest no specific interventions for prevention of PCOS in offspring of women with PCOS (2͉QEEE). | Additional health care resources should be directed to address the risks facing this population." Researchers analyzing the data found women who were diagnosed with PCOS were more likely to be hospitalized for reasons unrelated to reproductive health or injury than their counterparts. Women who had PCOS were more likel... | Whether these increased risks are due to PCOS itself or the features associated with PCOS such as IR or obesity requires further study. We suggest no specific interventions for prevention of PCOS in offspring of women with PCOS (2͉QEEE). Androgen levels may be increased in pregnant women with PCOS . | [2.0, 1.0, 1.0] | Medicine | train | 1.333333 | news | http://www.healthcanal.com/female-reproductive/59582-women-diagnosed-with-pcos-twice-as-likely-to-be-hospitalized.html |
10.1002/ijc.31746 | Medicine_170 | "We found that small genetic changes to the ANO7 gene increase a patient's risk of aggressive prostate cancer. | In our study, higher ANO7 mRNA expression strongly correlated with poor overall survival in PrCa patients. | They were particularly interested in studying mutations to the ANO7 gene because their previous research suggested this could be a gene of interest for prostate cancer. "We found that small genetic changes to the ANO7 gene increase a patient's risk of aggressive prostate cancer. Genetic testing for ANO7 could help iden... | on the other hand, reported high individual variability of ANO expression between individual samples, both in terms of absolute expression levels and of expression level ratios between matched normal and tumorous prostate. In our study, higher ANO7 mRNA expression strongly correlated with poor overall survival in PrCa ... | [4.0, 5.0, 5.0, 4.0, 4.0] | Medicine | train | 4.4 | news | http://ct.moreover.com/?a=34961246227&p=1pl&v=1&x=fiF8OmDGvWhClXOSUOnd9w |
10.1073/pnas.1515528113 | Medicine_171 | "The greatest benefits of HPV vaccination both in terms of cancer reduction and health care costs are realized when policy promoting vaccination is coordinated across states," said Alison Galvani, the Burnett and Stender Families Professor of Epidemiology and director of CIDMA. | Therefore, both cervical cancer incidence and expenditure can be substantially reduced if the states coordinate policies to promote expansion of coverage, particularly for the new nonavalent vaccine. | In addition, efforts to expand HPV vaccination, particularly in states with low coverage, could prevent even more cancers and deaths, said the researchers, adding that due to interstate migration, all states would benefit if they aligned vaccination policy. "The greatest benefits of HPV vaccination both in terms of can... | Because of interstate migration and the long duration between HPV infection and resultant cervical cancer, much of the benefit of vaccination will be realized beyond a state's borders. Therefore, both cervical cancer incidence and expenditure can be substantially reduced if the states coordinate policies to promote exp... | [4.0, 4.0, 3.0, 5.0] | Medicine | train | 4 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/tL7ylLtvSRo/ |
10.1001/jamapsychiatry.2015.0500 | Medicine_173 | Performing the most extensive analysis of antipsychotic use among children and adolescents of its kind, the study authors found that drugs normally recommended for the treatment of mental illnesses like schizophrenia and bipolar disorder are often being given to children and teens suffering from self-limiting behaviora... | This age profile refines earlier reports of steadily increasing rates of antipsychotic use across multiyear developmental categories of childhood to adolescence 28 to early adulthood. | Performing the most extensive analysis of antipsychotic use among children and adolescents of its kind, the study authors found that drugs normally recommended for the treatment of mental illnesses like schizophrenia and bipolar disorder are often being given to children and teens suffering from self-limiting behaviora... | There was a rise in antipsychotic use during childhood that extended into adolescence for females, followed by a plateau and a decline during the transition to early adulthood. This age profile refines earlier reports of steadily increasing rates of antipsychotic use across multiyear developmental categories of childho... | [3.0, 3.0, 3.0, 1.0, 2.0] | Medicine | train | 2.4 | news | http://www.medicaldaily.com/antipsychotics-are-being-given-kids-temporary-behavioral-problems-adhd-341188 |
10.1016/j.cell.2016.09.056 | Medicine_174 | The second surprise came with the unearthing of CD81's inner cavity and the discovery that it can hold a cholesterol molecule. | The tetraspanin CD81 contains a large intramembrane cavity occupied by cholesterol, indicating the potential for functional modulation by small molecules. | "It's different from all prior predictions," said Blacklow. The second surprise came with the unearthing of CD81's inner cavity and the discovery that it can hold a cholesterol molecule. That got the team especially excited, because it revealed that researchers can now try to manipulate CD81 using cholesterol or other ... | Cholesterol binding appears to modulate CD81 activity in cells, suggesting a potential mechanism for regulation of tetraspanin function. The tetraspanin CD81 contains a large intramembrane cavity occupied by cholesterol, indicating the potential for functional modulation by small molecules. The development of specializ... | [4.0, 4.0, 4.0] | Medicine | train | 4 | news | http://feedproxy.google.com/~r/TechnologyOrg/~3/Ay74vlkGcfw/ |
10.1038/s41467-018-07557-4 | Medicine_175 | "This is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisphere permafrost area under climate change," Hjort and his colleagues wrote in the paper. | Detrimental effects on engineered structures, socio-economic activities, and natural systems can, therefore, all be expected throughout the permafrost domain under climate warming 1 , particularly in high-risk areas with substantial urban and industrial centres such as Vorkuta and Novyi Urengoy in hot spots of infrastr... | The team found that 3.6 million people--three quarters of the current population in the Northern Hemisphere permafrost area--may be affected by infrastructure damage from permafrost thaw. "This is the first study to explicitly show the amount of fundamental infrastructure potentially at risk across the Northern Hemisph... | The potential harm to industrial facilities could be larger than estimated (pipelines: estimate = 32%, range = 24-70%; industrial areas: estimate = 25%, range = 20-64%) ( Fig. Detrimental effects on engineered structures, socio-economic activities, and natural systems can, therefore, all be expected throughout the perm... | [3.0, 4.0, 2.0, 3.0, 2.0] | Medicine | train | 2.8 | news | http://ct.moreover.com/?a=37952323296&p=1pl&v=1&x=YZkcSHKHdqhjfYYiUvZ_gw |
10.1016/j.ijnurstu.2014.02.007 | Medicine_177 | Recent catastrophic failures such as events at Mid-Staffordshire have highlighted the importance of staffing levels to patient survival, and this study has reinforced that message." | The estimated magnitude of these effects is similar to the corresponding estimates of their effects on the risk of mortality in the ICU. | Professor Elizabeth West, pictured, who led the research, says: "This is timely because the public are concerned about the ability of the NHS to provide safe and compassionate care. Recent catastrophic failures such as events at Mid-Staffordshire have highlighted the importance of staffing levels to patient survival, a... | Again, the number of nurses and the number of consultants per bed have a negative association with the risk of mortality. The estimated magnitude of these effects is similar to the corresponding estimates of their effects on the risk of mortality in the ICU. However, although both main effects are statistically signifi... | [2.0, 1.0, 2.0, 3.0, 5.0] | Medicine | train | 2 | news | http://www.healthcanal.com/public-health-safety/49249-low-icu-staffing-levels-affect-patient-survival.html |
10.1001/jamaoncol.2018.0798 | Medicine_18 | "Our findings underscore the importance of a thorough FDA review of new cancer therapies," said Cary Gross, M.D., senior author, YSM professor of medicine, and a member of Yale Cancer Center. | Overall, similar proportions of older and younger patients received anti-PD-1 treatment during the first 9 months after FDA approval. | The study results also concern the researchers because new therapies are being approved when questions remain about their risks and benefits. "Our findings underscore the importance of a thorough FDA review of new cancer therapies," said Cary Gross, M.D., senior author, YSM professor of medicine, and a member of Yale C... | Within 4 months after FDA approval, greater than 60% of eligible patients in each cohort had received anti-PD-1 treatment. Overall, similar proportions of older and younger patients received anti-PD-1 treatment during the first 9 months after FDA approval. However, there were significant differences in age between clin... | [1.0, 2.0, 1.0, 2.0] | Medicine | train | 1.5 | news | http://ct.moreover.com/?a=34024686802&p=1pl&v=1&x=V7M9zzFOhn6CjXB9WZIACw |
10.3945/jn.113.188441 | Medicine_181 | "My hope is that this study can lay a foundation for future research about the health effects of instant noodle consumption." | However, the stronger association between instant noodle consumption $2 times/wk and metabolic syndrome among women after excluding participants taking blood pressure-lowering and lipid-lowering medications or who had a history of diabetes mellitus might indicate the robustness of that association. | "This research is significant since many people are consuming instant noodles without knowing possible health risks," Dr. Shin said. "My hope is that this study can lay a foundation for future research about the health effects of instant noodle consumption." Dr. Shin added that the study's health implications could be ... | First, we cannot infer a causal relation given our cross-sectional study design. However, the stronger association between instant noodle consumption $2 times/wk and metabolic syndrome among women after excluding participants taking blood pressure-lowering and lipid-lowering medications or who had a history of diabetes... | [2.0, 2.0, 3.0, 2.0, 2.0] | Medicine | train | 2.2 | news | http://www.sciencedaily.com/releases/2014/08/140812121642.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1146/annurev-publhealth-031914-122421 | Medicine_182 | "As the Latino population continues to grow, it should be a national health policy priority to improve their access to care and determine the best way to deliver high-quality care to this population at the local, state and national levels," Ortega said. | Focusing on efforts to improve delivery systems for Latinos will likely reduce disparities in patients' experiences and the quality of primary care received. | The need to increase the number of Latino physicians and non-physician health care providers to address language and cultural barriers. "As the Latino population continues to grow, it should be a national health policy priority to improve their access to care and determine the best way to deliver high-quality care to t... | Differences in the quality of care appear to be largely attributable to the fact that Latinos are cared for in settings where communication and the quality of care are not especially patient-centered . Focusing on efforts to improve delivery systems for Latinos will likely reduce disparities in patients' experiences an... | [3.0, 2.0, 2.0] | Medicine | train | 2.333333 | news | http://www.sciencedaily.com/releases/2015/03/150319092222.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fmost_popular+%28Most+Popular+News+--+ScienceDaily%29 |
10.1038/s41598-018-30980-y | Medicine_183 | "This study demonstrates that napping is beneficial to memory processing," they point out. | Only of the 20 children with PSG reached REM in their nap (M% REM = 2.5%, SD = 4.51%). | As in observations by others, "both a nap and subsequent overnight sleep was necessary to observe performance benefits." "This study demonstrates that napping is beneficial to memory processing," they point out. "Given the importance of socio-emotional learning in preschool naps averaging 70 minutes may support the cur... | However, we were able to determine sleep latency on all 4, and REM latency on 2 of the unscorable wake night records, as the recording issues did not occur until later in the night. Only of the 20 children with PSG reached REM in their nap (M% REM = 2.5%, SD = 4.51%). For those children who reached REM sleep during the... | [3.0, 3.0, 1.0, 3.0, 1.0] | Medicine | train | 2.2 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1093/chemse/bjt066 | Medicine_185 | "Moreover, this is the first time we have been able to influence the edibility perception of an odour, even though the positive and negative labels accompanying the odours showed non-food words," adds Frasnelli. | Furthermore, we found an impact of labels on intensity ratings for one of the administered odors that goes against our hypothesis. | "It shows that odour perception is not objective: it is affected by the cognitive interpretation that occurs when one looks at a label," says Manescu. "Moreover, this is the first time we have been able to influence the edibility perception of an odour, even though the positive and negative labels accompanying the odou... | These findings further strengthen the concept that odor perception is influenced by cognitive interpretation. Furthermore, we found an impact of labels on intensity ratings for one of the administered odors that goes against our hypothesis. We found that participants rated geraniol as more intense when it was labeled p... | [3.0, 1.0, 3.0] | Medicine | train | 2.333333 | news | http://www.newswise.com/articles/smelling-with-our-eyes-descriptions-affect-odour-perception |
10.1073/pnas.1414221111 | Medicine_186 | In a mouse model of malaria, a single dose of (+)-SJ733 killed 80 percent of malaria parasites within 24 hours. | These morphological changes reach a maximum by 7-8 h after treatment. | In this study, researchers determined that (+)-SJ733 uses a novel mechanism to kill the parasite by recruiting the immune system to eliminate malaria-infected red blood cells. In a mouse model of malaria, a single dose of (+)-SJ733 killed 80 percent of malaria parasites within 24 hours. After 48 hours the parasite was ... | This immediate response triggers other cellular responses, probably including the arrest of protein synthesis , and these are integrated at the level of both the parasite (manifested as a swollen, development-arrested phenotype) and the host erythrocyte (manifested as induction of an eryptotic/senescent phenotype). The... | [2.0, 1.0, 2.0] | Medicine | train | 1.666667 | news | http://www.sciencedaily.com/releases/2014/12/141205175027.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news%2Ftop_science+%28ScienceDaily%3A+Top+Science+News%29 |
10.1038/s41551-018-0317-8 | Medicine_188 | AKI mice treated with rectangular DONs displayed improved kidney excretory function comparable to mice receiving treatment using the mainline drug NAC. | 64 Cu-Rec-DON showed rapid accumulation in the kidneys as early as 5 min post-injection ( Fig. | Examination of stained tissue samples further confirmed the beneficial effects of the DONs in the kidney. AKI mice treated with rectangular DONs displayed improved kidney excretory function comparable to mice receiving treatment using the mainline drug NAC. Results showed the DONs were non-immunogenetic and tissue stai... | 37 ). 64 Cu-Rec-DON showed rapid accumulation in the kidneys as early as 5 min post-injection ( Fig. 3c ) in AKI mice suggested that the injured kidneys may still extract and excrete DONs from the blood pool into the bladder, although at a decreased rate. | [4.0, 2.0, 2.0, 1.0, 2.0] | Medicine | train | 2.2 | news | http://ct.moreover.com/?a=37636191811&p=1pl&v=1&x=qc3pI9OOn-ja-gCCneNC8w |
10.1038/s41467-018-07557-4 | Medicine_189 | Concluding, the researchers say a detailed infrastructure risk assessment is needed to understand how communities in permafrost areas will be affected as the planet warms. | Here, the ground temperature and thaw of near-surface permafrost was considered to be the most important factor affecting infrastructure hazard followed by GIC, relative increase of ALT, fine-grained sediment content and slope gradient. | [To prevent the permafrost thawing], we need to stop climate warming." Concluding, the researchers say a detailed infrastructure risk assessment is needed to understand how communities in permafrost areas will be affected as the planet warms. He told Newsweek the part of the paper looking at Canada uses incorrect perma... | The AHP developed is a multi-objective, multicriteria decision-making approach to analyse complicated problems such as the determination of relative roles of factors affecting geohazards 70 . Here, the ground temperature and thaw of near-surface permafrost was considered to be the most important factor affecting infras... | [3.0, 5.0, 1.0, 2.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=37952048427&p=1pl&v=1&x=WVBbJHZ_CDGkehwcKPFvdQ |
10.1016/j.psyneuen.2016.08.027 | Medicine_19 | The research follows an earlier study which suggested that elevated long-term levels of cortisol may reduce the likelihood of a successful outcome for patients trying to conceive by IVF. | Despite these potential limitations, the present study extends the available evidence for the role of cortisol on clinical pregnancy in IVF patients and provides the first evidence that elevated chronic cortisol levels are associated with a reduced likelihood of pregnancy. | The research follows an earlier study which suggested that elevated long-term levels of cortisol may reduce the likelihood of a successful outcome for patients trying to conceive by IVF. However, many factors influence cortisol (including physical activity, sleep and some aspects of our diet such as caffeine) and so it... | It is also not clear how generalizable our results are to women trying to conceive naturally; also our findings extend only to clinical pregnancy. Despite these potential limitations, the present study extends the available evidence for the role of cortisol on clinical pregnancy in IVF patients and provides the first e... | [3.0, 5.0, 5.0, 5.0, 4.0] | Medicine | train | 4.4 | news | http://ct.moreover.com/?a=33739698938&p=1pl&v=1&x=AcVA0Y4hatHNh4-L_5fqfA |
10.1016/j.jpain.2017.11.005 | Medicine_191 | Acupuncture was similarly effective for each of these conditions, his study found. | Another novel finding is the higher than average effects of acupuncture on upper body musculoskeletal pain. | "If our study had been on a drug, we'd say the drug works--there's a statistically significant effect there," says Andrew Vickers, first author of that study and a biostatistician at Memorial Sloan Kettering Cancer Center in New York City. Acupuncture was similarly effective for each of these conditions, his study foun... | In some cases, heterogeneity was also driven by a set of outlying trials with large effect sizes. Another novel finding is the higher than average effects of acupuncture on upper body musculoskeletal pain. We now have sufficient data to conduct a meta-analysis for neck pain and for shoulder pain, even after exclusion o... | [2.0, 2.0, 3.0, 3.0, 4.0] | Medicine | train | 2.8 | news | http://ct.moreover.com/?a=38497695155&p=1pl&v=1&x=s_16A13LceP0QMt7V7o-QA |
10.1016/j.cell.2018.04.034 | Medicine_192 | This is an exciting prospect for patients who have CDK12 alterations and may benefit from immunotherapy," says senior study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology. | CDK12 mutant cases also lack mutational signatures of HRD ( Figure 3C ) and maintain the expression levels of BRCA1 and BRCA2 ( Figure S4J ). | The fact that immune checkpoint inhibitors may be effective against this sub-type of prostate cancer makes it even more significant. This is an exciting prospect for patients who have CDK12 alterations and may benefit from immunotherapy," says senior study author Arul Chinnaiyan, M.D., Ph.D., director of the Michigan C... | However, our data, and the observations made previously in CDK12 mutant ovarian tumors , are inconsistent with that model. CDK12 mutant cases also lack mutational signatures of HRD ( Figure 3C ) and maintain the expression levels of BRCA1 and BRCA2 ( Figure S4J ). Overall, the genomic phenotypes of HR and CDK12 deficie... | [1.0, 2.0, 3.0, 2.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=34304617241&p=1pl&v=1&x=JkbWFHiGsGoeqOJxN0A0-A |
10.1152/ajpregu.00204.2013 | Medicine_194 | A new study using an animal model to mimic key effects of PE in humans, and led by Graeme Smith of Queen's University, Canada, may help explain the lower incidence of PE in some smokers. | There are other potential beneficial effects of both HO-1 and CO in placental development and fetal survival. | A new study using an animal model to mimic key effects of PE in humans, and led by Graeme Smith of Queen's University, Canada, may help explain the lower incidence of PE in some smokers. The study also suggests a therapy that could offer similar protection against PE with none of smoking's well-known risks. Although to... | Our study did not evaluate the effect of CO on placental oxidative stress, and future work should aim to report on these findings. There are other potential beneficial effects of both HO-1 and CO in placental development and fetal survival. It would make sense then, that increasing one's CO levels could rescue some of ... | [1.0, 1.0, 3.0] | Medicine | train | 1.666667 | news | http://www.sciencedaily.com/releases/2013/09/130919154253.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1210/en.2015-2036 | Medicine_195 | In particular, we show that vitamin D deficiency directly results in an increase in the expression of a gene (called ID1) that promotes breast cancer metastasis. | We found that vitamin D-deficient mice developed mammary tumors that were palpable an average of 7 days earlier than control mice. | It is important to note that the research recommends avoiding deficiency which does not mean that taking more vitamin D than needed is beneficial. In particular, we show that vitamin D deficiency directly results in an increase in the expression of a gene (called ID1) that promotes breast cancer metastasis. Indeed, we ... | Ingestion of the LD25 diet caused a statistically significant decrease in serum 25(OH)D levels compared with control mice (Supplemental Figure 1) . We found that vitamin D-deficient mice developed mammary tumors that were palpable an average of 7 days earlier than control mice. Importantly, vitamin D deficiency also ac... | [5.0, 4.0, 4.0, 4.0, 4.0] | Medicine | train | 4.2 | news | http://www.theepochtimes.com/n3/1987536-vitamin-d-deficiency-promotes-breast-cancer-growth-in-mice/ |
10.1001/jamapsychiatry.2015.0500 | Medicine_196 | It's also not necessarily strange that these drugs were used in cases where the child had no mental health diagnosis, though it could suggest overuse. | There were approximately 270 000 antipsychotic prescriptions dispensed to younger children, 2.14 million to older children, 2.80 million to adolescents, and 1.83 million to young adults nationwide in 2010. | But because of the unknown risks that come with flooding a maturing brain with these drugs, they should be utilized only when it's absolutely necessary. It's also not necessarily strange that these drugs were used in cases where the child had no mental health diagnosis, though it could suggest overuse. The authors hope... | The age and sex composition of the IMS population that filled at least 1 prescription of any kind closely resembled the composition of the corresponding population from the nationally representative Medical Expenditure Panel Survey. There were approximately 270 000 antipsychotic prescriptions dispensed to younger child... | [2.0, 2.0, 1.0, 2.0, 2.0] | Medicine | train | 1.8 | news | http://www.medicaldaily.com/antipsychotics-are-being-given-kids-temporary-behavioral-problems-adhd-341188 |
10.1073/pnas.1509654112 | Medicine_197 | But things got interesting when they took a look at the individual brain scans: Only zero to eight percent of people had an aEURoeall maleaEUR or aEURoeall femaleaEUR brain, meaning most people have a mix of elements that are classified as both male and female in their brains. | Here we show that, although there are sex/gender differences in brain and behavior, humans and human brains are comprised of unique "mosaics" of features, some more common in females compared with males, some more common in males compared with females, and some common in both females and males. | They found 29 regions that seem to be different sizes in people who identified as male or female. But things got interesting when they took a look at the individual brain scans: Only zero to eight percent of people had an aEURoeall maleaEUR or aEURoeall femaleaEUR brain, meaning most people have a mix of elements that ... | Such an alignment may be predicted by the classic view of sexual differentiation of the brain, according to which masculinization and defeminization of the brain are under the sole influence of testosterone (9). Here we show that, although there are sex/gender differences in brain and behavior, humans and human brains ... | [3.0, 4.0, 2.0, 4.0, 4.0] | Medicine | train | 3.4 | news | http://healthmedicinet.com/news/science-proves-men-and-women-are-actually-from-the-same-planet/ |
10.1001/jama.2018.20578 | Medicine_198 | Compared with no aspirin, aspirin use correlated with significant reductions in the composite cardiovascular outcome (57.1 versus 61.4 per 10,000 participant-years; hazard ratio, 0.89; absolute risk reduction, 0.38 percent) and correlated with an increased risk for major bleeding events (23.1 versus 16.4 per 10,000 par... | While the reduction in cancer mortality emerged after at least 5 years of follow-up, this result was not replicated in the ASCEND trial that followed up 480 participants with diabetes for a mean of 7.4 years. | The researchers found that the median baseline risk for the primary cardiovascular outcome (composite of cardiovascular mortality, nonfatal myocardial infarction, and nonfatal stroke) was 9.2 percent. Compared with no aspirin, aspirin use correlated with significant reductions in the composite cardiovascular outcome (5... | This finding is in contrast to an individual patient data meta-analysis of primary and secondary prevention aspirin trials that demonstrated a % reduction in cancer mortality associated with aspirin use. While the reduction in cancer mortality emerged after at least 5 years of follow-up, this result was not replicated ... | [1.0, 2.0, 1.0, 1.0] | Medicine | train | 1.25 | news | http://ct.moreover.com/?a=38331905067&p=1pl&v=1&x=XtWX8D8AaSJygxxptr_VHw |
10.1073/pnas.1403984111 | Medicine_199 | "It is obvious that stemming the rate of illegal killing is paramount," the researchers conclude. | This threshold PIKE value can serve as a rule of thumb indicating excessive pressure that requires intervention if the corresponding population is to avoid extirpation. | And as the map above shows, that varies from country to country. "It is obvious that stemming the rate of illegal killing is paramount," the researchers conclude. ... [C]urbing demand -- particularly in the Far East -- appears necessary to reduce black market ivory prices and alleviate the unsustainable pressure from i... | Simulation results given our demographic parameterization indicated populations with PIKE of 0.54 were likely at equilibrium, with higher proportions associated with greater probabilities of decline ( Fig. This threshold PIKE value can serve as a rule of thumb indicating excessive pressure that requires intervention if... | [1.0, 1.0, 1.0, 2.0] | Medicine | train | 1.25 | news | http://www.vox.com/2014/8/20/6045505/more-than-100000-african-elephants-have-been-killed-by-poachers-since |
10.1038/s41598-018-30980-y | Medicine_2 | Further, Spencer and colleagues report, greater nap slow wave activity was associated with greater memory decay during the nap. | Yet nap slow wave activity also predicted greater overnight improvement in memory. | However, when memory was tested again following overnight sleep, the change in memory accuracy was greater if the child had napped the previous day. Further, Spencer and colleagues report, greater nap slow wave activity was associated with greater memory decay during the nap. Yet nap slow wave activity also predicted g... | Greater nap slow wave activity was associated with greater memory decay during the nap. Yet nap slow wave activity also predicted greater overnight improvement in memory. These results suggest that sleep bouts can interact to benefit memory in early childhood. | [4.0, 2.0, 1.0, 3.0, 3.0] | Medicine | train | 2.6 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1038/s41598-018-25573-8 | Medicine_20 | "The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. | Histological analysis revealed P53 complete loss in invasive carcinoma and intraepithelial carcinoma; and strongly (contiguous) positive in other areas. | In contrast, injection of free doxorubicin caused widespread organ damage, even when less amount was administered," write the investigators. "The lack of toxic effect of nanoparticle loaded doxorubicin was associated with specific delivery of doxorubicin to the tumor. Furthermore, we observed excellent tumor accumulati... | Moreover, malignant cells were present, consistent with adenocarcinoma (CK7+/CK20-/CDX-2-/CA-125+). Histological analysis revealed P53 complete loss in invasive carcinoma and intraepithelial carcinoma; and strongly (contiguous) positive in other areas. Ki67 was elevated in invasive carcinoma and intraepithelial carcino... | [1.0, 1.0, 1.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=34218407527&p=1pl&v=1&x=TZ9cA3HHZNB3jHckRRSErA |
10.1016/j.stemcr.2018.03.019 | Medicine_200 | X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs. | This analysis further defined the dynamic regulation of DNA methylation with single-CpG resolution within enhancers during female reprogramming and revealed expected as well as unexpected single-CpG-level DNA methylation changes. | Note: material may have been edited for length and content. For further information, please contact the cited source. X Chromosome Dosage Influences DNA Methylation Dynamics during Reprogramming to Mouse iPSCs. | This analysis enabled us to assess changes in DNA methylation at single CpG resolution, which could be masked in averages. This analysis further defined the dynamic regulation of DNA methylation with single-CpG resolution within enhancers during female reprogramming and revealed expected as well as unexpected single-Cp... | [2.0, 1.0, 2.0] | Medicine | train | 1.666667 | news | http://ct.moreover.com/?a=33847856937&p=1pl&v=1&x=vV_Dne2GAjTKIkp14dSTOw |
10.1038/s41598-018-30980-y | Medicine_202 | Change in memory accuracy also did not differ when tested after a nap compared to the change in memory accuracy after an interval awake, they report. | Greater nap slow wave activity was associated with greater memory decay during the nap. | To do this, they presented children ages approximately three to five years (34-64 months) with faces paired with mean or nice word descriptions, but they saw no significant main effects of emotional valence on recognition memory. Change in memory accuracy also did not differ when tested after a nap compared to the chan... | However, when memory was probed again following overnight sleep, the change in memory accuracy was greater if the child napped the previous day. Greater nap slow wave activity was associated with greater memory decay during the nap. Yet nap slow wave activity also predicted greater overnight improvement in memory. | [2.0, 2.0, 1.0, 1.0] | Medicine | train | 1.5 | news | http://ct.moreover.com/?a=34884544095&p=1pl&v=1&x=ZTfu4WJpcprjoFwmcebiPw |
10.1111/gcb.13526 | Medicine_203 | Alternatively, plants with fewer leaves are more water efficient, and thereby may be potentially drought tolerant." | The additional savings in roots could then be used to further increase seed yield, making our predicted yield increase estimates conservative. | Cutting down on roots could produce additional carbon savings that the plant can invest towards boosting yield. Alternatively, plants with fewer leaves are more water efficient, and thereby may be potentially drought tolerant." Next, the researchers will bioengineer plants or search for varieties that naturally have fe... | S7) , plants with lower LAI can potentially have fewer roots and save on root investment and maintenance costs. The additional savings in roots could then be used to further increase seed yield, making our predicted yield increase estimates conservative. Alternatively maintaining the same amount of root, yet decreasing... | [1.0, 3.0, 2.0] | Medicine | train | 2 | news | http://healthmedicinet.com/news/soybean-plants-with-fewer-leaves-yield-more/ |
10.1534/genetics.116.197285 | Medicine_205 | We argue resistance could be thought of as a good thing -- if we know it's going to evolve, we can plan around it, and understand a gene drive is a temporary solution. | We have shown that for values of μ in this range, resistance is already likely when N e = 6 , which is compatible with estimates from levels of neutral diversity in insect populations 22 . | "Basically, looking at the numbers and assuming a simple gene drive system, it's a foregone conclusion that resistance will evolve," Unckless said. We argue resistance could be thought of as a good thing -- if we know it's going to evolve, we can plan around it, and understand a gene drive is a temporary solution. "Obv... | In addition, indels should occur within the 20 bp-long target sequence at rates comparable to the single nucleotide mutation rate 21 . We have shown that for values of μ in this range, resistance is already likely when N e = 6 , which is compatible with estimates from levels of neutral diversity in insect populations 2... | [4.0, 1.0, 1.0] | Medicine | train | 1 | news | http://healthmedicinet.com/news/research-shows-nature-can-beat-back-scientific-tinkering-with-genes-of-entire-species/ |
10.1126/scitranslmed.aab1290 | Medicine_206 | DHED could be particularly useful in treating women who prematurely enter menopause after surgery, because they have the most drastic changes in hormone levels and often deal with symptoms for the longest, he points out. | We reveal the therapeutic potential of DHED on estrogen deficiency-associated neurological disorders and psychiatric conditions without encountering adverse systemic actions that are typically seen with the direct use of estrogens. | "Because this prodrug remains completely inactive everywhere else in the body, you can remedy the neurological and psychiatric symptoms associated with estrogen deficiency while avoiding side effects in the rest of the body," Prokai says. DHED could be particularly useful in treating women who prematurely enter menopau... | Although this method provides increased selectivity in CNS delivery of the hormone, it still generates elevated levels of the hormone in the periphery with substantial uterotrophic side effects and sustained high circulating estrogen levels even after acute dosing . We reveal the therapeutic potential of DHED on estrog... | [2.0, 3.0, 4.0, 2.0, 4.0] | Medicine | train | 3 | news | http://news.sciencemag.org/biology/2015/07/safer-estrogen-therapy-women |
10.1002/hec.3070 | Medicine_207 | While still imposing a relatively low tax burden, it could lead to weight reductions of up to 3.64 kilograms in middle-income heavy consumers of sweetened beverages. | Thus the per capita, per year, weight loss as a result of the tax is almost six times greater for heavy drinkers relative to persons drinking at an average level. | The effect would be even more striking if a 20 cents per litre volumetric tax were applied. While still imposing a relatively low tax burden, it could lead to weight reductions of up to 3.64 kilograms in middle-income heavy consumers of sweetened beverages. This was chiefly because although a sales tax would have a big... | Using this conversion criteria a reduction of 16,087 kJ as a result of the SSB tax translates into a reduction in body weight of 0.44 Kg (16,087/36,500 Kj) per year at mean level of consumption. Thus the per capita, per year, weight loss as a result of the tax is almost six times greater for heavy drinkers relative to ... | [2.0, 3.0, 2.0, 3.0] | Medicine | train | 2.5 | news | http://www.sciencedaily.com/releases/2014/06/140617094037.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1039/c3cs60122f | Medicine_209 | Second, you must support researchers in their journey from paper to digital, as there are a lot of ELN software providers and not enough concrete information. | Forcing users to abandon paper notebooks and instead use an ELN is unlikely to be successful, users are much more likely to adopt an ELN if they can see some proven value that is relevant to their own work. | We should recognize that every lab has its own unique needs, and that there is no one-size-fits-all available today. Second, you must support researchers in their journey from paper to digital, as there are a lot of ELN software providers and not enough concrete information. Finally but most importantly, any ELN provid... | The authors of the information often do not share these same goals to the same extent, and the recording of their activities and data, and standardization of data entry, 4 is second to other aims such as performing the research activities and the interpretation of the data. Forcing users to abandon paper notebooks and ... | [3.0, 3.0, 3.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=37060720905&p=1pl&v=1&x=mJkzlHa3lmu5bv8uh9G1ig |
10.1016/j.cell.2018.04.034 | Medicine_210 | It was found to be more common in metastatic prostate cancer compared to early stage tumors that had not spread. | Further, we identify that CDK12 mutant tumors have synthetic genetic dependencies and a characteristic immunophenotype, which provide candidate targets for precision therapy. | It was found to be more common in metastatic prostate cancer compared to early stage tumors that had not spread. Tumors in which CDK12 was inactivated were responsive to immune checkpoint inhibitors, a type of immunotherapy treatment that has overall had limited success in prostate cancer. "Because prostate cancer is s... | We show that CDK12 mutants are genetically, transcriptionally, and phenotypically distinct from HRD and MMRD tumors. Further, we identify that CDK12 mutant tumors have synthetic genetic dependencies and a characteristic immunophenotype, which provide candidate targets for precision therapy. We detected aberrations of C... | [1.0, 1.0, 1.0, 3.0, 1.0] | Medicine | train | 1.4 | news | http://ct.moreover.com/?a=34322199988&p=1pl&v=1&x=uADO-y4eWDsh9N-tizLZ7Q |
10.1152/ajpregu.00204.2013 | Medicine_211 | And, since PE is a multifaceted disorder that begins with abnormal placental development before progressing to maternal disease, the results also suggest the possibility of preventing or treating early PE in humans with controlled CO dosages. | One of the goals of using CO as a possible future therapeutic in patients with PE would be to lower plasma sFLT1 levels. | This study, the first to look at the effects of CO on the placenta in mice, found that exposing the animals to inhalable CO increased blood flow and vascular growth in the developing placenta, created more, bigger, and stronger connections to the mother's uterus, a process that provides more oxygen and nutrients to the... | Therefore, it is possible that in our study, exposure to CO would not affect maternal plasma sFLT1 or VEGF levels until alterations in normal levels were first induced. One of the goals of using CO as a possible future therapeutic in patients with PE would be to lower plasma sFLT1 levels. In this regard, future studies... | [3.0, 4.0, 4.0, 2.0] | Medicine | train | 3.25 | news | http://www.sciencedaily.com/releases/2013/09/130919154253.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1210/jc.2013-2350 | Medicine_214 | "The Society's recommendations allow physicians to make the diagnosis if clear symptoms are present without resorting to universal hormone tests or ultrasound screening." | We do not endorse the need for universal screening with androgen assays or ultrasound if patients already meet two of the three criteria clinically. | "The Society's recommendations allow physicians to make the diagnosis if clear symptoms are present without resorting to universal hormone tests or ultrasound screening." In the CPG, The Endocrine Society recommends that a diagnosis be made if adult women have two of the three cardinal features of PCOS (diagnostic crit... | These criteria allow the diagnosis to be made clinically (based upon a history of hyperandrogenic chronic anovulation) as well as biochemically with androgen assays or with ultrasound examination of the ovaries. We do not endorse the need for universal screening with androgen assays or ultrasound if patients already me... | [4.0, 4.0, 5.0, 5.0, 5.0] | Medicine | train | 4.6 | news | http://www.sciencedaily.com/releases/2013/10/131024121206.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1002/hec.3070 | Medicine_215 | "In absolute terms, the difference in tax over a year can be considered negligible, but the weight change could be significant, making these changes very cost effective," Sharma says. | This means that despite the lower tax burden, the reduction in consumption and body weight is higher under a volumetric tax. | Those who had been heavier consumers would lose more--between 1 and 2 kilos, or about 2 to 4.5 pounds. "In absolute terms, the difference in tax over a year can be considered negligible, but the weight change could be significant, making these changes very cost effective," Sharma says. The effect would be even more str... | The tax burden under a 20% valoric tax and a 20 cents/litre volumetric tax is around $17 and $11 per capita per year, respectively. This means that despite the lower tax burden, the reduction in consumption and body weight is higher under a volumetric tax. This is an interesting result, even more interesting for high l... | [4.0, 3.0, 4.0] | Medicine | train | 3.666667 | news | http://www.theepochtimes.com/n3/778129-higher-soda-tax-may-help-consumers-tighten-their-belt/ |
10.1016/j.celrep.2016.08.013 | Medicine_216 | By calculating the displacement of bacteria from the endothelial cells, the researchers also found that the microbes use bungee-cord-like tethers to stabilize and strengthen these bonds. | This finding suggested that motility is possibly strong enough to modulate the force imposed on load-bearing bonds and drive active bacterial migration over endothelia under PCV shear stress. | "Our in vitro live-cell-imaging-based system will permit more efficient dissection of the underlying interaction mechanisms and more rapid screening for inhibitors of bacterial-endothelial interactions and dissemination." By calculating the displacement of bacteria from the endothelial cells, the researchers also found... | Thus, unexpectedly, B. burgdorferi experienced forces that were small enough to be overcome by bacterial motility. This finding suggested that motility is possibly strong enough to modulate the force imposed on load-bearing bonds and drive active bacterial migration over endothelia under PCV shear stress. We also found... | [4.0, 4.0, 2.0, 4.0] | Medicine | train | 3.5 | news | https://www.sciencedaily.com/releases/2016/08/160825130027.htm |
10.1007/s00125-014-3400-z | Medicine_217 | Our results suggest that preventive strategies, such as an effective vaccine against EV infection, may lessen the incidence of type 1 diabetes in Taiwan." | The incidence rate of type 1 diabetes was lower in the non-EV than the EV group (4 vs 6 per 100,000 person-years; incidence rate ratio 1.48 [95% CI 1.19, 1.83]) ( Table 2 ). | They add: "Taiwan has relatively low type 1 diabetes incidence; we believe that the marked escalation of the said incidence in recent decades can be largely attributed to the highly endemic spread of enterovirus infection in Taiwanese children, given that there has been little gene flow and genetic drift in such a shor... | Compared with the non-EV group, the EV group had a significantly higher prevalence of atopic dermatitis, allergic rhinitis and bronchial asthma ( Table 1) . The incidence rate of type 1 diabetes was lower in the non-EV than the EV group (4 vs 6 per 100,000 person-years; incidence rate ratio 1.48 [95% CI 1.19, 1.83]) ( ... | [4.0, 3.0, 5.0, 4.0] | Medicine | train | 4 | news | http://www.sciencedaily.com/releases/2014/10/141017183715.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Ftop_news+%28ScienceDaily%3A+Top+News%29 |
10.1210/jc.2013-2350 | Medicine_218 | Women who had PCOS were more likely to have miscarriages, ectopic pregnancies or other gynecological conditions such as irregular menstrual periods and endometriosis. | We recognize that the diagnosis of PCOS in postmenopausal women is problematic but feel that it is unlikely that a woman can develop PCOS in the perimenopause or menopause if she has not had symptoms earlier. | Researchers analyzing the data found women who were diagnosed with PCOS were more likely to be hospitalized for reasons unrelated to reproductive health or injury than their counterparts. Women who had PCOS were more likely to have miscarriages, ectopic pregnancies or other gynecological conditions such as irregular me... | Very high T levels and/or virilization may suggest an androgen-producing tumor in postmenopausal women. We recognize that the diagnosis of PCOS in postmenopausal women is problematic but feel that it is unlikely that a woman can develop PCOS in the perimenopause or menopause if she has not had symptoms earlier. 2.1 We ... | [3.0, 2.0, 3.0] | Medicine | train | 2.666667 | news | http://www.healthcanal.com/female-reproductive/59582-women-diagnosed-with-pcos-twice-as-likely-to-be-hospitalized.html |
10.1038/s41598-018-25573-8 | Medicine_219 | The biodegradable PMO carrying doxorubicin quickly eliminated the human ovarian tumours without affecting other organs in the chicken embryo. | The above results show that the nanoparticle formulation enables a higher amount of doxorubicin to be administered safely. | This is a major step toward individualized medicine for cancer patients. The biodegradable PMO carrying doxorubicin quickly eliminated the human ovarian tumours without affecting other organs in the chicken embryo. When a smaller amount of the drug, not enveloped in the nanoparticles, was injected in the egg, severe or... | Doxorubicin is specifically delivered to the tumor after intravenous administration of doxorubicin loaded MSNs. The above results show that the nanoparticle formulation enables a higher amount of doxorubicin to be administered safely. As can be seen in Fig. | [2.0, 2.0, 2.0, 4.0, 3.0] | Medicine | train | 2.6 | news | http://ct.moreover.com/?a=34220579892&p=1pl&v=1&x=hyv7yBfI9spqaAdmPr3ViA |
10.1001/jamapediatrics.2018.0302 | Medicine_22 | "Moreover, we found that the lower dose of vitamin D supplementation (up to 2,000 IU a day) reduced risk of fetal or neonatal mortality and infants being small for gestational age, but higher doses (more than 2,000 IU a day) did not reduce the risk of perinatal mortality and infants being small for gestational age," We... | Late vitamin D supplementation (initiation at ≥20 weeks' gestation) improved birth weight, but early supplementation (initiation at <20 weeks' gestation) did not. | And supplementation reduced infants' risk of being small for gestational age and improved their calcium levels and growth in the first 12 months of life. "Moreover, we found that the lower dose of vitamin D supplementation (up to 2,000 IU a day) reduced risk of fetal or neonatal mortality and infants being small for ge... | We found that maternal vitamin D supplementation timing, dose, and administration method did not affect cord blood vitamin D concentration. Late vitamin D supplementation (initiation at ≥20 weeks' gestation) improved birth weight, but early supplementation (initiation at <20 weeks' gestation) did not. Most importantly,... | [1.0, 1.0, 5.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=34180824606&p=1pl&v=1&x=LymT53igqmp5seujNS7GFA |
10.1016/j.ijnurstu.2014.02.007 | Medicine_220 | Recent catastrophic failures such as events at Mid-Staffordshire have highlighted the importance of staffing levels to patient survival, and this study has reinforced that message." | In the third column, however, we can see that the equivalent interaction is not significant when it involves the number of consultants. | Professor Elizabeth West, pictured, who led the research, says: "This is timely because the public are concerned about the ability of the NHS to provide safe and compassionate care. Recent catastrophic failures such as events at Mid-Staffordshire have highlighted the importance of staffing levels to patient survival, a... | Column two shows that the interaction variable is negative and significant, implying that the reduction in mortality risk from having more nurses is larger for patients who are the most severely ill. In the third column, however, we can see that the equivalent interaction is not significant when it involves the number ... | [1.0, 1.0, 2.0, 1.0] | Medicine | train | 1.25 | news | http://www.healthcanal.com/public-health-safety/49249-low-icu-staffing-levels-affect-patient-survival.html |
10.1001/jamapediatrics.2018.0302 | Medicine_221 | This amount of vitamin D was tied to 55 percent lower odds of an underweight baby and 65 lower chance of a baby dying in the womb or during infancy. | Vitamin D supplementation was associated with higher neonatal vitamin D status (bolus-or regular-dose supplement and early or late timing were equally effective in attaining improvement in vitamin D levels), higher calcium levels, higher Apgar scores, greater neonatal skinfold thickness, greater weight (at birth, 3 mon... | But prenatal vitamin D supplements only appeared to have these benefits when women took 2,000 International Units (IU) or less each day. This amount of vitamin D was tied to 55 percent lower odds of an underweight baby and 65 lower chance of a baby dying in the womb or during infancy. At higher doses, any differences b... | Vitamin D supplementation during pregnancy with lower doses (≤2000 IU/d) was associated with a reduced risk of fetal and neonatal mortality. Vitamin D supplementation was associated with higher neonatal vitamin D status (bolus-or regular-dose supplement and early or late timing were equally effective in attaining impro... | [3.0, 3.0, 4.0] | Medicine | train | 3.333333 | news | http://ct.moreover.com/?a=34180824606&p=1pl&v=1&x=LymT53igqmp5seujNS7GFA |
10.1038/s41467-019-09863-x | Medicine_225 | Still, in the meantime, there are other kinds of "tipping points" that may be of much more immediate concern, according to climate scientist Robert Kopp of Rutgers University, who commented on the new study for E&E News. | Our results show that the PCF gets progressively stronger in warmer climates, while the SAF weakens. | On that kind of time scale, their impact could be formidable. Still, in the meantime, there are other kinds of "tipping points" that may be of much more immediate concern, according to climate scientist Robert Kopp of Rutgers University, who commented on the new study for E&E News. Kopp pointed to the risk of socio-eco... | While not modelled directly, many of these effects are included implicitly in the PAGE-ICE IAM through a number of uncertain climate system parameters constrained according to the latest literature (Methods, Supplementary Note 1). Our results show that the PCF gets progressively stronger in warmer climates, while the S... | [1.0, 1.0, 4.0, 1.0, 1.0] | Medicine | train | 1 | news | http://ct.moreover.com/?a=39068075992&p=1pl&v=1&x=s9tSrEITwL3rwfEi9cWT-w |
10.1098/rspb.2013.3172 | Medicine_226 | Our research suggests that health officials need to have a really good understanding of the social context to better understand vaccine scares and why people refuse vaccines. | Vaccine scares can have long-term impacts on vaccine coverage, causing depressed coverage even after the perceived vaccine risk has returned to baseline levels. | "They are strongly influenced by other parents and what they read. Our research suggests that health officials need to have a really good understanding of the social context to better understand vaccine scares and why people refuse vaccines. Bauch believes this may steadily lead to less immunized children, where popula... | The social learning rate k can also influence whether the population converges to no vaccine coverage or returns to full vaccine coverage, after a vaccine scare (figure 5). Vaccine scares can have long-term impacts on vaccine coverage, causing depressed coverage even after the perceived vaccine risk has returned to bas... | [4.0, 3.0, 2.0, 3.0] | Medicine | train | 3 | news | http://www.medicaldaily.com/spread-infectious-diseases-influenced-vaccine-scares-and-public-paranoia-269370 |
10.1073/pnas.1318978111 | Medicine_229 | Authors believe the study provides potential biological targets to enhance fertility in women with diminished ovarian reserve, who produce few or no follicles in response to IVF drugs designed to boost follicle development. | S2D ), suggesting that androgens promote FSHR protein expression independent of transcription. | Authors believe the study provides potential biological targets to enhance fertility in women with diminished ovarian reserve, who produce few or no follicles in response to IVF drugs designed to boost follicle development. "Our study doesn't solve the controversy, but, along with some earlier seminal studies from othe... | 5A ) nor testosterone (Fig S2D) alters FSHR mRNA levels, but both significantly increase FSHR protein expression (Fig. S2D ), suggesting that androgens promote FSHR protein expression independent of transcription. S3A ), indicating that DHT promotes FSHR protein expression by enhancing translation through extranuclear ... | [1.0, 1.0, 3.0, 1.0, 1.0] | Medicine | train | 1.4 | news | http://www.sciencedaily.com/releases/2014/03/140304141948.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1007/s13524-014-0324-7 | Medicine_230 | These are some of the reasons to think this isn't random (and that this non-randomness is bad news for women):
"First, if men and women expect families to prioritize husbands' careers in relocation decisions, this may in turn compel women to sort into flexible occupations, thereby reproducing occupational segregation.... | In other words, the tendency for families to relocate for men's careers may be a feature of men's and women's ex ante career choices rather than families' ex post prioritization of husband's careers, and therefore endogenous. | Note that the occupations on the left-hand side are, on the whole, much higher paid than the ones on the right. These are some of the reasons to think this isn't random (and that this non-randomness is bad news for women):
"First, if men and women expect families to prioritize husbands' careers in relocation decisions... | However, occupations are not random by sex, and mobility is not random by occupation; this assumption is violated if men and women segregate into geographically constrained and flexible occupations, as would be the case if their career choices are made in anticipation of the two-body problem or if labor market processe... | [3.0, 4.0, 2.0, 2.0] | Medicine | train | 2.75 | news | http://www.businessinsider.com/why-women-choose-more-flexible-careers-2014-11 |
10.1146/annurev-publhealth-031914-122421 | Medicine_231 | Their analysis, published in the March issue of the Annual Review of Public Health, identifies four problem areas related to health care delivery to Latinos under ACA:
The consequences of not covering undocumented residents. | Research into health care disparities affecting Latinos will likely change rapidly during the next two decades because of two important policy and sociodemographic changes. | Latinos' low rates of insurance coverage and poor access to health care strongly suggest a need for better outreach by health care providers and an improvement in insurance coverage. Their analysis, published in the March issue of the Annual Review of Public Health, identifies four problem areas related to health care ... | Care 535 patient, provider, and system factors that explains such disparities . Research into health care disparities affecting Latinos will likely change rapidly during the next two decades because of two important policy and sociodemographic changes. First, the implementation of the ACA will provide new topics of inq... | [4.0, 1.0, 2.0, 4.0, 2.0] | Medicine | train | 1 | news | http://www.sciencedaily.com/releases/2015/03/150319092222.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily%2Fmost_popular+%28Most+Popular+News+--+ScienceDaily%29 |
10.1038/s41598-018-29793-w | Medicine_232 | "It's not going to be so simple, I don't think, as saying, 'OK, what happens if you give a probiotic?'" | We demonstrated that the baseline nasal microbiota clusters were associated with subsequent nasal inflammatory response, viral titer, and symptom severity in rhinovirus infection. | So it's not like the probiotic alters the microbiome of the gut in any substantial way." It's possible that administering a probiotic directly to the nose, such as through a spray, could have more effect. "It's not going to be so simple, I don't think, as saying, 'OK, what happens if you give a probiotic?'" | Whether intranasal administration of probiotic to the human host would amplify the effects seen following oral administration remains to be determined. We demonstrated that the baseline nasal microbiota clusters were associated with subsequent nasal inflammatory response, viral titer, and symptom severity in rhinovirus... | [3.0, 2.0, 2.0, 1.0] | Medicine | train | 2 | news | http://ct.moreover.com/?a=37225510845&p=1pl&v=1&x=cC_QQTJtCDR1qED9-8SGHg |
10.1038/s41589-018-0155-8 | Medicine_234 | However, in further experiments conducted by the laboratory of study co-senior author John Teijaro, an assistant professor in the Department of Immunology and Microbiology at Scripps Research, it was clear that the reduction in ABHD12 activity had a big effect on the mouse immune system. | Taken together, these data indicate that the inactivation of ABHD12 promotes increased lung ) , regulated on activation, normal T cell expressed and secreted. | The rise wasn't as great as that seen in the ABHD12-knockout mice, and even four weeks of treatment with the inhibitor appeared to cause only slight hearing defects -- nothing like the profound defects experienced by PHARC patients. However, in further experiments conducted by the laboratory of study co-senior author J... | Finally, ABHD12 -/mice that survived the initial exaggerated immune response (~days 8-15) displayed a gradual reduction in viral titers in the serum and lung over the ensuing weeks (Fig. Taken together, these data indicate that the inactivation of ABHD12 promotes increased lung ) , regulated on activation, normal T cel... | [4.0, 2.0, 3.0, 4.0, 5.0] | Medicine | train | 3.6 | news | http://ct.moreover.com/?a=37814264274&p=1pl&v=1&x=fV_-TrzPs9X1ZtNnkmq4RQ |
10.1038/s41598-018-26198-7 | Medicine_236 | Their analyses further suggested that stretching may impact on two possibly related mechanisms that are relevant to cancer--immune cell exhaustion and inflammation resolution. | We next examined tumor cytokine levels and found that, even though individual group differences were not statistically significant, overall levels of inflammatory mediators, including IL-2, IL-6, IL-10, TNF-α and INF-γ, were up-regulated in the stretch group (Table 1) . | Their analyses further suggested that stretching may impact on two possibly related mechanisms that are relevant to cancer--immune cell exhaustion and inflammation resolution. Writing in their published paper in Scientific Reports, the researchers conclude, "The potential clinical significance of our results lies in th... | We found no significant difference in the abundance of macrophages expressing CD64 (M1) and CD206/Arg (M2) between stretch and no-stretch groups ( Table 1 ). We next examined tumor cytokine levels and found that, even though individual group differences were not statistically significant, overall levels of inflammatory... | [4.0, 3.0, 3.0, 2.0, 3.0] | Medicine | train | 3 | news | http://ct.moreover.com/?a=34125675804&p=1pl&v=1&x=EIuTbzUDbEKkr7kvXb-kdg |
10.1001/jamapsychiatry.2015.0500 | Medicine_238 | Psychotherapy has made progress but is still being utilized by only a small portion of young people being treated with antipsychotics, according to the study. | Less than one-fourth of the patients in each of the age groups had an outpatient claim for psychotherapy (younger children, 13.5%; older children, 20.4%; adolescents, 24.8%; young adults, 18.8%) ( Table 4) . | "We may need to put greater effort into increasing access to psychosocial interventions that can treat symptoms and behaviors that are currently being addressed with antipsychotic medications." Psychotherapy has made progress but is still being utilized by only a small portion of young people being treated with antipsy... | Among antipsychotic-treated children and adolescents with mental disorder claims, the most common diagnosis was ADHD (younger children, 52.5%; older children, 60.1%; adolescents, 34.9%), while depression was the most common diagnosis among young adults (34.5%), followed by bipolar (26.6%) and anxiety disorders (22.9%).... | [5.0, 2.0, 3.0, 2.0] | Medicine | train | 4 | news | http://www.medicaldaily.com/prescription-drug-use-retrospective-study-shows-decreased-antipsychotic-drug-340770 |
10.1001/jamasurg.2018.0672 | Medicine_24 | "Our results suggest that functional health literacy can now also be included as an influencing factor for the quality of postoperative recovery," wrote the authors, who added that FHL should be considered a relevant factor in considering how to best optimize recovery for patients undergoing day surgery.In a linked com... | Health literacy is a relevant factor to consider for optimizing the postoperative recovery in patients undergoing day surgery. | Those with inadequate FHL had the following when compared with those with sufficient FHL:Health-related quality of life, as measured by the EuroQol-visual analog scale, also revealed poorer outcomes for those with inadequate FHL; this group had worse scores for physical function, vitality, social functioning, and menta... | CONCLUSIONS AND RELEVANCE Inadequate FHL in patients undergoing day surgery was associated with poorer postoperative recovery and a lower health-related quality of life. Health literacy is a relevant factor to consider for optimizing the postoperative recovery in patients undergoing day surgery. 6 Considering this, the... | [5.0, 4.0, 5.0, 5.0] | Medicine | train | 4.75 | news | http://ct.moreover.com/?a=33887433087&p=1pl&v=1&x=9eFFYNmEjRb2HVG-5W6y0Q |
10.1210/jc.2013-2350 | Medicine_240 | Other recommendations from the CPG include:
* Because women with PCOS face an increased risk of pregnancy complications such as gestational diabetes, preterm delivery and preeclampsia that can be exacerbated by obesity, women should have their body mass index, blood pressure and oral glucose tolerance assessed prior t... | In addition, the nocturnal drop in mean arterial blood pressure is lower, a finding that has also been demonstrated in obese adolescents with PCOS . | "The Society's recommendations allow physicians to make the diagnosis if clear symptoms are present without resorting to universal hormone tests or ultrasound screening." In the CPG, The Endocrine Society recommends that a diagnosis be made if adult women have two of the three cardinal features of PCOS (diagnostic crit... | Women with PCOS should have BMI and blood pressure measured at each clinic visit (and consider waist circumference if nonobese; Ն 36 inches is abnormal), and upon diagnosis of PCOS, additional testing should include a complete fasting lipid profile (total cholesterol, LDL-cholesterol, non-HDL-cholesterol, HDL-cholester... | [4.0, 4.0, 2.0, 5.0] | Medicine | train | 3.75 | news | http://www.sciencedaily.com/releases/2013/10/131024121206.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28ScienceDaily%3A+Latest+Science+News%29 |
10.1016/j.molcel.2014.05.030 | Medicine_241 | D'Orazio and his research team found an important molecular link between MC1R signaling and DNA repair in their study. | In any case, our findings suggest that PKA-mediated phosphorylation of ATR at Ser435 is an important event that dynamically regulates early recruitment/assembly of XPA and possibly other DNA repair proteins to sites of UV damage to optimize NER. | "If you tend to burn, then you may have inherited a problem with your MC1R, and you probably should avoid purposeful UV exposure like tanning bed use or unprotected sun exposure." D'Orazio and his research team found an important molecular link between MC1R signaling and DNA repair in their study. The team hopes to use... | It is possible that the phospho-Ser435 ATR-XPA complex recognizes UV damaged sites through RPA binding (Zou and Elledge, 2003) or perhaps via the excision gap generated by NER . In any case, our findings suggest that PKA-mediated phosphorylation of ATR at Ser435 is an important event that dynamically regulates early re... | [3.0, 3.0, 3.0] | Medicine | train | 3 | news | http://www.sciencedaily.com/releases/2014/07/140715141753.htm?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+sciencedaily+%28Latest+Science+News+--+ScienceDaily%29 |
10.1001/jamapsychiatry.2015.0500 | Medicine_242 | "Antipsychotics should be prescribed with care," says Michael Schoenbaum, co-author of the study and senior adviser for mental health services, epidemiology and economics at the National Institute of Mental Health. | Young adults treated with antipsychotics were more frequently diagnosed as having depression, bipolar disorder, and anxiety disorder than ADHD. | "Antipsychotics should be prescribed with care," says Michael Schoenbaum, co-author of the study and senior adviser for mental health services, epidemiology and economics at the National Institute of Mental Health. Even after medication has stopped, these effects may still persist. The percentage dropped to about half ... | Consistent with clinical diagnoses suggesting that antipsychotics are primarily used to manage impulsive or aggressive behaviors in children associated with ADHD, 27 the highest rate of antipsychotic treatment was in adolescent boys, approximately half of whom also filled prescriptions for stimulants. Young adults trea... | [2.0, 4.0, 4.0, 3.0] | Medicine | train | 3.25 | news | http://www.techtimes.com/articles/65576/20150702/boys-with-adhd-more-likely-to-be-given-antipsychotics-study.htm |
10.1038/s41467-019-08382-z | Medicine_243 | These interactions help Hel2 identify flaws in protein formation. | The major Hel2 crosslink site (C1490-A1492 in yeast; C1554-A1556 in human) and the minor crosslink site of the 3' domain (U1362 in yeast; U1426 in human) both lie close to the 40S-40S interface, indicating that Hel2 and Asc1 may be even closer than judged from the monosome structure. | This clears the way for further proteins to be produced. These interactions help Hel2 identify flaws in protein formation. When researchers removed the parts of Hel2 in direct contact, this prevented the destruction of faulty proteins, showing that these contacts are important for the mechanism. | In collided diribosomes, the interface between both 40S subunits contains hRACK1 of the first (stalled) ribosome and hRPS10, hRPS20 and hRPS3 of the following (collided) ribosome 45 and hRPS10 ubiquitination by hZNF598 happens in the context of the collided ribosomes 45 . The major Hel2 crosslink site (C1490-A1492 in y... | [4.0, 2.0, 2.0, 3.0, 3.0] | Medicine | train | 2.8 | news | http://ct.moreover.com/?a=38442592628&p=1pl&v=1&x=6qnjJlZN_F0RgmqDHnl0dA |
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