PMC_ID stringlengths 8 11 | Image_num stringclasses 399 values | Online_file_path stringlengths 20 50 ⌀ | Image_info_Cleaned stringlengths 2 20.6k | Caption_Clean stringlengths 1 10.6k ⌀ | label stringclasses 2 values |
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PMC9515104 | Figure_1 | oa_package/bc/77/PMC9515104.tar.gz | [' 1a illustrates an exemplary WSI with pathologist annotations in the SlideRunner user interface.', 'User interfaces of recommended open source software tools for dataset visualization.', 'EXACTEXACT enables the collaborative analysis of the dataset with integrated annotation versioning.', ' 1b shows an overview of the demo dataset in EXACT.'] | Fig. 1 User interfaces of recommended open source software tools for dataset visualization. ( ) SlideRunner. ( ) EXACT. | yes |
PMC10454703 | Figure_1 | oa_package/b0/04/PMC10454703.tar.gz | ['ATRX status was determined in 40 CM cases, with 9 cases (23%) showing ATRX loss ().', 'The flow chart in concerns the analysis of the different conjunctival melanocytic lesions, depicting the results from the benign lesions (green boxes) versus the (pre)malignant lesions (red boxes), with ATRX loss only found in the (pre)malignant conjunctival melanocytic lesions.', 'However, ATRX loss was found in two cases (40%) of PAM+ without an invasive component and five cases (71%) of PAM+ with invasive component ().', 'One case with recurrent disease had an unknown ATRX status ().', 'Two cases with metastatic disease had an unknown ATRX status ().', 'Only one CM case with metastatic disease revealed neither a TERT promoter mutation nor ATRX loss ().', '1186/s40942-022-00374-435365243TERT promoter and ATRX status in conjunctival melanocytic lesions.'] | Figure 1 promoter and status in conjunctival melanocytic lesions. These images are meant to highlight the methods that are used to obtain the data (H&E staining and immunohistochemistry instead of other (diagnostic) methods; Microscope's magnification or scale bar is not of relevance for understanding this figure. Exact data concerning these images can be provided upon request. | yes |
PMC8633817 | Figure_1 | oa_package/44/92/PMC8633817.tar.gz | ['The single major complication occurred in a 79-year-old male subject who developed a symptomatic moderate-sized pneumothorax following biopsy of a prevascular (anterior) mediastinal mass using a transpleural approach ().', 'Major complication of a large pneumothorax following biopsy of a prevascular mass (arrow) in a 78-year-old male patient with subsequent diagnosis of thymoma.'] | Figure Major complication of a large pneumothorax following biopsy of a prevascular mass (arrow) in a 78-year-old male patient with subsequent diagnosis of thymoma. A,B Contrast enhanced computed tomography (CT) showing infiltrative prevascular mediastinal mass in both lung and soft tissue windows in patient status post median sternotomy. C, CT image showing transpleural pathway of biopsy needle. D, CT shows postbiopsy symptomatic moderate-sized pneumothorax requiring chest tube insertion. | yes |
PMC8679157 | Figure_1 | oa_package/46/93/PMC8679157.tar.gz | ['4\n\nTreatment given\n\nOral corticosteroids in tapering doses for 4 weeks\n\nOral corticosteroids in tapering doses for 2 weeks\n\nOral corticosteroids in tapering doses for 2 weeks\n\nPost treatment Radiology\n\nClearing of reticulations GGOs\n(s 1b 2b)\n\nClearing of GGOs\n(b)\n\nClearing of reticulations\n(b)\n(a), Case 1 Chest X-ray (posteroanterior view) showing bilateral diffuse reticulations; (b), Case 1 showing clearing of reticulations after 7 weeks(a), Case 1 CT scan of chest showing patchy areas of ground glass opacities.'] | Figure 1 (a), Case 1 Chest X-ray (posteroanterior view) showing bilateral diffuse reticulations; (b), Case 1 showing clearing of reticulations after 7 weeks | yes |
PMC7977697 | Figure_44 | oa_package/de/90/PMC7977697.tar.gz | [] | Figure 18: Combined pulmonary fibrosis and emphysema. Coronal CT image demonstrates upper lungpredominant centrilobular and paraseptal emphysema with additional lower lung, peripheral-predominant reticular abnormality, traction bronchiectasis, and honeycomb cyst formation. | yes |
PMC7481605 | Figure_3 | oa_package/86/e2/PMC7481605.tar.gz | ['On chest CT scan, the PPM appeared as an isolated, round, solid, and well-circumscribed nodule, with or without lobulation (A,B).', 'PPMs on CT.'] | Figure 3 PPMs on CT. (A,B) PPMs showing as isolated, round, solid, and well-circumscribed nodules, with or without lobulation. PPMs, primary pulmonary meningiomas; CT, computed tomography. | yes |
PMC8360022 | Figure_2 | oa_package/e3/a2/PMC8360022.tar.gz | [] | FIGURE 2 Performance of two trained models for individual patient in the test set. (a) Model 1 performance for classifying cancer vs. benign. (b) The number of patients that were identified correct or incorrect by Model 1, negative predictive value, positive predictive value, specificity, sensitivity, and accuracy for cancer vs. benign. (c) Model 2 performance for classifying high risk vs. low risk. (d) The number of patients that were identified correct or incorrect by Model 2, negative predictive value, positive predictive value, specificity, sensitivity, and accuracy for high risk vs. low risk. | yes |
PMC3868051 | Figure_3 | oa_package/ed/c0/PMC3868051.tar.gz | ['Fractional mesangial area was evaluated as described in Research Design and Methods (A and B).', 'Nondiabetic GLO1-KD (Aband B, bar 2) showed a twofold increase in mesangial expansion compared with nondiabetic Wt mice (', 'In these nondiabetic mice, mesangial expansion was increased to the same degree as in diabetic Wt mice (Adand B, bar 4).', 'In contrast, mesangial expansion in kidneys of diabetic GLO1-Tg mice (Afand B, bar 6) was the same as in nondiabetic Wt mice.', 'Fractional mesangial area in nondiabetic GLO1-Tg mice was reduced 50% compared with nondiabetic WT mice (, bar 3).', 'Quantitation of mesangial fractional volume (n = 15).', 'GBM thickness was evaluated by ultrastructural analysis of electron micrographs as described in Research Design and Methods ().'] | Figure 3 Quantitation of mesangial fractional volume ( = 15). : Representative photomicrographs of PAS-stained glomeruli from kidneys of nondiabetic and diabetic Wt ( ), GLO1-KD ( ), and GLO1-Tg ( ) mice. Original magnification 600. : Quantitation of mesangial fractional volume for each group of mice. Data are expressed as mean SD (* < 0.05 vs. Wt; # < 0.05 vs. STZ-Wt; ANOVA). | yes |
PMC10576788 | Figure_3 | oa_package/74/76/PMC10576788.tar.gz | [' 3a).', ' 3b).', 'RfxCas13d reduces ATXN2 mRNA in the brain and spinal cord.', 'Using its hemagglutinin epitope (HA) tag for detection, we observed at four weeks post-injection that RfxCas13d was present throughout the brain, including in the motor, somatosensory, and visual cortices (MC, SSC and VC respectively), the brainstem (BS), the striatum (STR), the hippocampus (HPC), the cerebellum (CBM), and the spinal cord (SC; ', ' 3c g and Supplementary ', ' 3d h Supplementary ', ' 3i and Supplementary '] | Fig. 3 RfxCas13d reduces ATXN2 mRNA in the brain and spinal cord. Schematic of the AAV vector encoding RfxCas13d and its crRNA. ITR, inverted terminal repeat; CBh, chicken -actin promoter; NLS, nuclear localization signal; BGH, bovine growth hormone polyadenylation signal. Overview of the experimental plan. ICV, intracerebroventricular; IV, intravenous. Representative immunofluorescence staining of the dorsal sagittal section of the brain (scale bar, 1mm), motor cortex (MC; scale bar, 50m), hippocampus [HPC; scale bar, (left) 100m, (right) 50m], striatum (STR; scale bar, 50m), spinal cord [SC; scale bar, (left) 500m, (right) 100m]. , Images were acquired by tile-scanning using an AxioScan.Z1 (Carl R. Woese Institute for Genomic Biology, Univ. Illinois) and subsequently stitched together to display a larger view. Quantification of the percentage of NeuN cells positive for the HA epitope tag. Values represent means and error bars indicate SD ( =3). >104 NeuN cells counted were per replicate. Relative mATXN2 mRNA in B6SJLF1/J mice injected with AAV9-CBh-RfxCas13d-mATXN2. Data are normalized to relative mATXN2 mRNA from B6SJLF1/J mice injected with AAV9-CBh-RfxCas13d-NTG. Values represent means and error bars indicate SD ( =4 for the MC; =5 for NTG and =4 for mATXN2 in the HPC, =4 for the STR, =5 for NTG and =4 for mATXN2 in the BS; =4 for the SC). Data were compared using a one-tailed unpaired -test, with the exact -values shown. All analyses were conducted four weeks post-injection. All data points are biologically independent samples. | yes |
PMC1475889 | Figure_5 | oa_package/76/99/PMC1475889.tar.gz | ['Strong and diffuse cytoplasmic reactivity for bcl-2 in case 11.'] | Figure 5 Strong and diffuse cytoplasmic reactivity for bcl-2 in case 11. | yes |
PMC4885100 | Figure_1 | oa_package/29/3e/PMC4885100.tar.gz | ['Virus was detectable in the serum starting at 1 dpi by both real-time RT-PCR (A C) and the plaque assay (D) for the Ken06 group.', 'By 2 dpi, four of five in the SA01 group and three of five in the Ken06 group were positive by real-time RT-PCR, and also, three of five in both groups were viremic (A D).', 'Peak viremia determined by the plaque assay occurred at 2 and 3 dpi (D).', 'Cattle infected with the SA01 strain were all negative by both real-time RT-PCR (A C) and the plaque assay by 4 dpi (D).', 'Cattle inoculated with the Ken06 strain were negative by real-time RT-PCR (A C) by 5 dpi, but some weakly positive Ct values above the standard threshold cut-off of 35 were detected out to 7 dpi.', 'No virus plaques were detected by Day 5 dpi for Ken06 (D).', '06190-11\n22156530Kinetics of viral RNA and virus titers for calves infected with RVFV strains, SA01 (blue) and Ken06 (gray).'] | Figure 1 Kinetics of viral RNA and virus titers for calves infected with RVFV strains, SA01 (blue) and Ken06 (gray). The mean with the standard deviation of change in Ct values; (40-Ct)/40 ( ) RVFV L RNA segment (dashed line indicates standard Ct = 35 cut-off or 0.13 change in Ct), ( ) RVFV M RNA segment and ( ) RVFV S RNA segment from calf serum are shown; ( ) viral titers in pfu/mL. To be considered positive by the multiplex real-time RT-PCR, the Ct value for at least two of the three RVFV genome segments must be less than or equal to 35 [ ]. | yes |
PMC4083547 | Figure_5 | oa_package/df/1c/PMC4083547.tar.gz | [] | Figure 2d Anterior progression of TME dissection to the posterior wall of the vagina (arrows) | yes |
PMC4747167 | Figure_5 | oa_package/7b/f0/PMC4747167.tar.gz | ['Analysis of the effect of alcohol and oleate on the activation of autophagyPHH or HepG2 E47 cells were pre-incubated with 0.'] | Figure 5 Analysis of the effect of alcohol and oleate on the activation of autophagy PHH or HepG2 E47 cells were pre-incubated with 0.2mM oleate (Ol) or BSA (served as control) for 24h. Subsequently, cells were co-incubated with/without chloroquine [CQ] (10 M) for 1 h before adding 50 mM alcohol (Alc) to cultured medium for additional 24h. Analysis of LC3I/II protein levels in PHH by Western blot analysis (left panel); densitometric analysis of LC3II/I ratio of 3 experiments (right panel). Analysis of p62 protein expression in PHH by Western blot analysis (upper panel); densitometric analysis of p62 protein of 3 experiments (lower panel). Analysis of LC3I/II protein levels in HepG2 E47 cells by Western blot analysis. Analysis of ATG7 mRNA and protein levels in PHH by quantitative RT-PCR and Western blot analysis. Actin served as control for loading adjustment. Analysis of cellular mRNA levels of VPS34 in PHH by quantitative RT-PCR. Analysis of cellular mRNA levels of ATG7 and VPS34 by quantitative RT-PCR in HepG2 C34 (not expressing CYP2E1) in comparison with HepG2 E47 cells (expressing CYP2E1). Analysis of cellular mRNA levels of ATG7 and VPS34 by quantitative RT-PCR in HepG2 E47 cells (Ctrl cells) in comparison to chlormethiazole (CMZ) or N-acetylcysteine (NAC)-treated cells. (*: < 0.05 compared to corresponding control; #: < 0.05 compared to corresponding oleate or alcohol condition). | yes |
PMC6853637 | Figure_2 | oa_package/6e/27/PMC6853637.tar.gz | ['In A, a cross section of the WT EDL graft with the neighbouring recipient TA muscle is presented.', 'In WT donor grafts, at day nine post-engraftment, the graft had regenerated new myofibers with little remaining necrotic muscle at the core (; images A, B and E).', 'In contrast in the Sun1 / donor grafts (; images C, D and F), necrotic muscle fibres persisted and occupied more than half the central region of the graft.', 'Although myogenesis had initiated at the graft periphery, the persistence of necrotic muscle fibers revealed that myogenesis was defective (F).', 'The total numbers of regenerated myofibers and necrotic myofibers were quantified in each graft and expressed as percentage of muscle regeneration (G) with regeneration being significantly retarded (p 0.', '10.', '004.', '10.', '005 figure supplement 1.', '10.', '006 figure supplement 2.', 'The persistent presence of necrotic myofibers in the Sun1 / grafts probably impedes new myofiber synthesis, as previously demonstrated in other muscle grafts (Shavlakadze et al.', 'However, there was no difference in the number of regenerated myofibers at day nine post-grafting ( figure supplement 1).', 'H and I show the myofiber size distribution in these grafts, with Sun1 / myofiber size distribution being smaller than WT myofibers in both the autografts and transplants into a different host.', 'The SUN1 7 antibody strongly stained the NEs of newly formed WT myofibers within the EDL graft, and to a much lesser extent the peripheral nuclei of the host TA muscle (J,L and M).', 'SUN1 was not detectable in the myofiber nuclei in the Sun1 / grafts (arrowheads) using the SUN1 7 antibody (N,P and Q).', 'The Sun1 7 antibody localized SUN1 to the LaminB1 positive nuclear envelopes (NE) of WT nuclei in myotubes differentiated in culture ( figure supplement 2B upper panels), with Sun1 / myofibers not showing any antibody localization to the NEs confirming its specificity ( figure supplement 2B lower panels).', 'Intriguingly however, in vitro, the loss of SUN1 during myotube differentiation did not overtly impede the differentiation of myoblasts into myotubes ( figure supplement 2C).', 'We showed that transplanted WT EDL muscle into a SUN1 null host and the reciprocal experiment did not rescue muscle regeneration ( figure supplement 2A).'] | 10.7554/eLife.49485.003 | yes |
PMC11424814 | Figure_7 | oa_package/c8/3c/PMC11424814.tar.gz | [] | FIGURE 7 Dorsal lesions induced by different concentrations of TAM. (A) The dorsal skin lesions induced by different dosages of TAM. (B) Histopathology of the back skin. The dorsal skin pathology of mice exhibited significant inflammation and necrosis at a dose of 100mg/kg. However, at a dose of 70mg/kg, the dorsal skin pathology of mice was nearly normal. (C) Immunohistochemistry for Mvd of the dorsal skin (Scale bars, 100m). The data are performed as mean SEM. * < .05, ** < 0.01, *** < 0.001 by using student's test. | yes |
PMC11391139 | Figure_4 | oa_package/52/77/PMC11391139.tar.gz | ['This improves the sonic window, protects surrounding organs from thermal damage, and reduces pain ().', 'Schematic of artificial injection of ascites.'] | Fig. 4 Schematic of artificial injection of ascites. (A) Subphrenic tumors may not be clearly visible on ultrasonographic imaging owing to poor sonic windows. (B) Injecting artificial ascites creates a space between the diaphragm and liver, improving the sonic window by filling this space with fluid. Creating and filling the spaces between the liver and diaphragm, the liver and abdominal wall, the gastrointestinal tract, and other nearby organs can reduce the risk of inadvertent damage to adjacent organs during local ablation procedures. | yes |
PMC3166122 | Figure_4 | oa_package/1b/ab/PMC3166122.tar.gz | ['0010) [[\n: A\n]].', '0110) [[\n: A\n]].', 'g004Microvascular Density is increased in Aged Tg2576 and in Human patients with AD.', 'In the cortex, the ratio of CD105 to -actin was nearly double [[\n: B\n]] in the Tg2576 mice (4.', '05, t-test) [[\n: C\n]].', '25 ) [[\n: D\n]].', '23 ) [[\n: E\n]].', 'The extent of the increased cortical cerebral vascular density from laminin staining in the AD patient [[\n: G\n]] can be visually seen in the representative images compared to the ND patient control [[\n: F\n].', 'Furthermore, in a preliminary examination of well-characterized normal and AD reference standards of postmortem medial cortical and hippocampal brain tissues also exhibit significant hypervascularity in AD, far beyond that present in a normal human brain [[\n: F G\n]].'] | 10.1371/journal.pone.0023789.g004 | yes |
PMC10739299 | Figure_3 | oa_package/b1/23/PMC10739299.tar.gz | ['Initial ECG on admission showing sinus tachycardia, premature atrial complexes with aberrant conduction, right bundle branch block, atrial premature complexes, and aberrant conduction of supraventricular beats.'] | Figure 3 Initial ECG on admission showing sinus tachycardia, premature atrial complexes with aberrant conduction, right bundle branch block, atrial premature complexes, and aberrant conduction of supraventricular beats. | yes |
PMC3796764 | Figure_4 | oa_package/64/aa/PMC3796764.tar.gz | ['They also expressed LTi related genes such as LT and , TRANCE and CXCR5, recently found to be important for the recruitment of LTi-like cells during inflammation (Supplementary ) (refs 13, 14).', 'We found that depletion of Thy1+ cells completely abrogated -CD40 induced innate colitis (a,b), but did not affect the IL-23-independent systemic wasting disease (', 'Furthermore, depletion of Thy1+SCA-1+ cells was associated with a significant decrease in production of IFN- , IL-22, TNF- but not MCP-1 or IL-6 in the colon (d).', 'Indeed, we found high expression of ROR t by Thy1hiSCA-1+ cells isolated from the colons of -CD40 treated mice (e).', 'Although treatment of Rag / Rorc / mice with -CD40 mAb elicited potent systemic inflammation and wasting disease comparable to that observed in Rag / mice (data not shown), Rag / Rorc / mice developed only mild intestinal inflammation (f and g).', 'ROR t-expressing Thy1hi innate lymphoid cells are required for -CD40-induced innate intestinal inflammation.'] | Figure 4 RORt-expressing Thy1 innate lymphoid cells are required for -CD40-induced innate intestinal inflammation. Colitis scores ( ), colon photomicrographs (50) ( ) weight loss ( ) and cLP cytokine secretion following overnight culture ( ) in -CD40 treated C57BL/6 mice injected with or without -Thy1 or isotype control mAb. mRNA expression by sorted Thy1 SCA-1 or the remaining cLP cells (Rest) from -CD40 treated mice. Results are representative of 2 independent experiments. Colitis scores ( ) and photomicrographs (50) ( ) from -CD40 treated C57BL/6 or C57BL/6 mice. ( ) Data represent pooled results from two experiments (n=6-10 ) and ( , ) (n=11-13). ( ) Data represents mean s.e.m. (n=5).**P<0.01; ***P<0.001. | yes |
PMC5775400 | Figure_6 | oa_package/2e/93/PMC5775400.tar.gz | ['Adult Spin1M5 mice exhibit a severe scoliosis, cachexia, and weigh only around 60% of control littermates (s 6a and b).', 'Inspection of hind limb muscles revealed as the most prominent feature an abnormally thin and pale soleus (SOL) muscle in Spin1M5 mice (c).', 'Other hind limb muscles (gastrocnemius (GC), plantaris (PL), TA, extensor digitorum longus (EDL), and quadriceps (QC)) also displayed a reduced mass relative to controls (d; Supplementary a).', 'H E staining confirmed degeneration of the soleus as evidenced by rounded fibers, enormous differences in fiber diameters, and the presence of inflammatory cells (e).', 'Major defects were also observed in the TA, while gastrocnemius and EDL appeared largely normal (e).', 'The TA of control mice exhibited typical fiber type compositions, that is, mainly type IIb fibers in white (primarily glycolytic) TA and type IIa and IIx fibers in red (primarily oxidative) TA (f, top and middle rows).', 'NADH staining correlated with the glycolytic or oxidative properties of the fiber types (f, bottom row).', 'In comparison, in the TA of some Spin1M5 mice, fiber types could not be clearly distinguished since most fibers expressed varying levels of MHC-IIx, in part together with MHC-IIb (f).', 'We rarely observed type IIa fibers in the TA of these animals (f).', 'org/1999/xlink" xlink:href="cddis2017468f5"/>Surviving Spin1M5 mice exhibit major defects in soleus, tibialis anterior, and diaphragm.'] | Figure 6 Surviving Spin1 mice exhibit major defects in soleus, tibialis anterior, and diaphragm. ( ) Appearance ( ) and average body weight ( ) of Spin1 and control mice ( =5 females in each category) at 30 weeks of age. Error bars represent +S.D., ** <0.01. ( ) Degeneration of the soleus (SOL) muscle in adult Spin1 compared with control mice exemplified at 16 weeks of age. ( ) Hind limb muscles (gastrocnemius (GC), plantaris (PL), soleus, tibialis anterior (TA), extensor digitorum longus (EDL), and quadriceps (QC)) of Spin1 and control mice at 30 weeks of age. Arrows point at the soleus embedded in gastrocnemius and plantaris, which is visible in control but degenerated in Spin1 mice. ( ) Hematoxylin & eosin (H&E) staining of gastrocnemius, soleus, TA, and EDL muscle of Spin1 and control mice at 30 weeks of age. ( ) Fiber types in glycolytic (white) or oxidative (red) parts of the TA of Spin1 and control mice at 15 weeks of age (top and middle rows) observed by immunofluorescence (IF) staining. Tissue sections were stained with selective antibody directed against MHC-I (purple), MHC-IIb (cyan), MHC-IIa (red), and MHC-IIx (green). For comparison, NADH staining was included (bottom row). Fibers with abnormal NADH staining are marked with arrows. Corresponding fibers in each column of images are squared | yes |
PMC8573288 | Figure_4 | oa_package/e2/8e/PMC8573288.tar.gz | ['5 cm from the uninvolved resected edge with positive FGFR1 immunohistochemistry staining consistent with a phosphaturic mesenchymal tumor (', ''] | Fig.4 Dark, diffuse positive brown immunohistochemistry staining for FGFR1. | yes |
PMC2847211 | Figure_3 | oa_package/bb/1f/PMC2847211.tar.gz | [] | Fig. (2a) Mitral regurgitation. | yes |
PMC8304847 | Figure_3 | oa_package/c3/93/PMC8304847.tar.gz | ['Results showed that Occludin expression significantly decreased (A,C, *** p 0.', '001), and Claudin-2 expression were significantly increased (B,D, *** p 0.', 'However, Occludin expression was significantly increased (A,C, *** p 0.', '001) whereas Claudin-2 expression decreased significantly (B,D, *** p 0.', 'No significant change in Occludin or Claudin-2 protein expression was observed between the vehicle-treated control, and the only AG-treated mice groups (A D, NS = non-significant).', 'GW chemical exposure causes gut leakiness due to altered expression of intestinal tight junction proteins, improved by AG treatment.'] | Figure 3 GW chemical exposure causes gut leakiness due to altered expression of intestinal tight junction proteins, improved by AG treatment. Formalin-fixed, paraffin-embedded 5 m intestinal slices from CONTROL (mice treated with vehicle only), GWT (GW chemical exposed mice), GWT+AG (mice co-exposed to both GW chemicals and AG), and AG (mice treated with AG only) groups were used for immunofluorescence imaging. Representative immunofluorescence images depicting ( ) Occludin and ( ) Claudin-2 reactivity (red) in the small intestine, counterstained with DAPI (blue) of CONTROL, GWT, GWT+AG, and AG mice groups. Images were taken at 40 magnification. Morphometric analysis (calculated as %ROI) of ( ) Occludin and ( ) Claudin-2 immunoreactivity. -axis represents % positive immunoreactive area (% ROI) ( = 3; mean value taken from three separate microscopic fields) (*** < 0.001, NS: non-significant). Data were represented as mean SEM and statistical significance was tested using unpaired -test between the groups (* < 0.05, ** < 0.01, *** < 0.001), followed by Bonferroni Dunn Post hoc corrections. | yes |
PMC6061861 | Figure_4 | oa_package/50/dc/PMC6061861.tar.gz | ['Le patient fut admis au bloc, nous avons r alis une ablation de la plaque v sicale emportant toute la masse tumorale (), avec une d rivation urinaire externe: ur t rostomie cutan e trans-il ale type bricker.'] | Figure 4 Pice opratoire (cystectomie radicale) | yes |
PMC10458919 | Figure_4 | oa_package/75/c0/PMC10458919.tar.gz | [' and Table 5 shows the MAPK immune staining of experimental groups.', 'In general, cells in the lamina propria showed negative MAPK immune reactions; however, macrophages showed positive MAPK expression (a).', 'It can be stated that MAPK initiates the signaling pathways in the endometriosis group (b).', 'Quince gel shows a tissue protective effect and downregulates the signaling (c).', 'While quince gel alone restored the pathology and downregulated the MAPK signaling, the combination of HES with quince gel has an especially anti-inflammatory effect (d).', 'Immune staining of MAPK (a) Sham group: Positive MAPK expression in surface epithelium (arrow), glands (arrowhead) and macrophages (asterisk); (b) EM group: Positive MAPK expression in the epithelium (black arrow), vessels (black arrowhead), glands (red arrowhead) in the EM group; (c) EM+QG group: Positive MAPK expression in the epithelium (black arrow), uterine glands (black arrowhead); (d) EM+QG+HES group: Negative MAPK expression in the epithelium and lamina propria (black arrow), positive MAPK expression in glands and inflammatory cells (black arrowhead), vessel (red arrowhead).'] | Figure 4 Immune staining of MAPK ( ) Sham group: Positive MAPK expression in surface epithelium (arrow), glands (arrowhead) and macrophages (asterisk); ( ) EM group: Positive MAPK expression in the epithelium (black arrow), vessels (black arrowhead), glands (red arrowhead) in the EM group; ( ) EM+QG group: Positive MAPK expression in the epithelium (black arrow), uterine glands (black arrowhead); ( ) EM+QG+HES group: Negative MAPK expression in the epithelium and lamina propria (black arrow), positive MAPK expression in glands and inflammatory cells (black arrowhead), vessel (red arrowhead). | yes |
PMC8655624 | Figure_3 | oa_package/db/05/PMC8655624.tar.gz | ['Mobile chest radiograph after left sided peripherally inserted central catheter (PICC) insertion using the blind pushing technique.'] | Figure 3 Mobile chest radiograph after leftsided peripherally inserted central catheter (PICC) insertion using the blind pushing technique. The tip of the PICC is in the azygous vein (arrow). | yes |
PMC10741466 | Figure_1 | oa_package/78/f1/PMC10741466.tar.gz | ['Various techniques have been developed including RFA, MWA (), cryoablation, and irreversible electroporation (IRE).', 'id=19-C-0094(accessed on 4 December 2023)66-year-old woman with cirrhosis secondary to autoimmune hepatitis and HCC, treated with microwave ablation.'] | Figure 1 66-year-old woman with cirrhosis secondary to autoimmune hepatitis and HCC, treated with microwave ablation. ( ) Arterial phase MRI showing a 3.5 cm arterially enhancing mass in the periphery of segment 7. ( ) Delayed phase MRI demonstrating washout of the mass. Intraprocedural axial ( ) and coronal ( ) CT images demonstrating probe placement bracketing the mass. ( ) Arterial phase MRI one month post ablation showing no residual viable tumor. ( ) Arterial phase MRI one year post ablation demonstrating no residual or recurrent viable tumor and involution of the ablation cavity. | yes |
PMC11250557 | Figure_3 | oa_package/aa/1c/PMC11250557.tar.gz | ['A CT angiogram of the abdomen shows contrast extraversion within the ascending colon (A).'] | Figure 3 A CT angiogram of the abdomen shows contrast extraversion within the ascending colon (Figure ). Interventional radiology (IR)-coil embolization of the right colic artery with a suspected Dieulafoy lesion is seen (Figure ). | yes |
PMC6054362 | Figure_4 | oa_package/7a/77/PMC6054362.tar.gz | [" Ultrasonographic image of the polyp (blue arrow)Heterotopic pancreatic tissue located in gallbladder (H E x100)H E: hematoxylin and eosinDiscussionThe heterotopic pancreatic tissue is often seen in the stomach, duodenum, and in the jejunum, Meckel's diverticulum, and mesentery [2]."] | Figure 4 Ultrasonographic image of the polyp (blue arrow) | yes |
PMC10665002 | Figure_4 | oa_package/9a/97/PMC10665002.tar.gz | [] | Fig.4. Anti-RGMa antibody had therapeutic potential in mSOD1 mice. (A to C) Clinical scores in the mSOD1 mice treated with anti-RGMa Ab ( = 12) and control Ab ( = 12) are shown. ( ) Anti-RGMa Ab prolonged the survival of mSOD1 mice by a mean of 8.4 days ( = 0.0065). ( ) Anti-RGMa Ab significantly mitigated body weight loss ( = 0.033), shown as the ratio to bodyweight in 10-week-old mice. ( ) Anti-RGMa Ab in the mSOD1 mice improved their motor function measured by the rotarod test ( = 0.0099). ( ) Nissl staining of the ventral horn of the spinal cord in mSOD1 mice is shown. Anti-RGMa Ab administration preserved the number of motor neurons with normal morphology ( = 5 for the control Abtreated group and = 5 for the anti-RGMa Abtreated group). Representative images are shown. Scale bar, 100 m. ( ) Immunohistochemical analysis showed that anti-RGMa Ab treatment reduced the number of ubiquitin-positive neurons in mSOD1 mice ( = 3 for the control Abtreated group and = 7 for the anti-RGMa Abtreated group). Representative images are shown. Scale bar, 300 m. ( ) Immunohistochemical analysis revealed that anti-RGMa Ab administration reduced the accumulation of SOD1 protein ( = 4 for the control group and = 6 for the anti-RGMa Abtreated group). Representative images are shown. Scale bar, 300 m. Error bars indicate mean SEM. | yes |
PMC10866662 | Figure_7 | oa_package/af/86/PMC10866662.tar.gz | ['RNA-Seq of full-thickness skin from the back of P4 K14Cre+Kctd1fl/flKctd15fl/fl mice versus WT littermates showed a strong increase in the expression of the alarmin keratins Krt6 and Krt16 and the hair follicle stem cell regulator Foxi3, as well as Stfa2, which plays a role in epidermal differentiation (, A C).', 'Genes downregulated in P4 skin of K14Cre+Kctd1fl/flKctd15fl/fl mice included regulators of fatty acid metabolism (Elovl6, Scd1), which are expressed in the skin mainly in sebaceous glands (, A and B, and Supplemental 0F).', 'Gene Ontology analysis of the differentially expressed genes showed a link to changes in keratinocyte differentiation, fatty acid metabolism, and calcium ion transport processes (D).', 'Gene set enrichment analysis (GSEA) provided evidence for abnormal extracellular matrix/keratinocyte interactions in the mutant skin as well (downregulation of genes linked to elastic fiber formation, cross-linking of collagen fibrils, and activation of matrix metalloproteinases) (E).', 'We also found upregulation of Foxi3, Krt16, and Stfa2 in epidermis derived from P22 K14Cre+Kctd1fl/flKctd15fl/fl mice (telogen/anagen transition phase), indicating a key role of these genes in keratinocytes for the observed abnormalities (C).', 'GSEA linked gene expression changes in the epidermis of P22 K14Cre+Kctd1fl/flKctd15fl/fl mice to alterations in PPAR signaling, retinol metabolism, and regulation of lipid storage (E).', 'Transcriptomic characterization of skin abnormalities in K14Cre+Kctd1fl/flKctd15fl/fl mice.'] | Figure 7 Transcriptomic characterization of skin abnormalities in mice. ( ) Volcano plot of RNA-Seq data from back skin of P4 control mice compared with mice. ( ) Heatmap shows expression of selected differentially expressed genes (DEGs) in the back skin of P4 control mice compared with mice. Upregulated DEGs in the skin of mice include , , and (arrows). ( ) Venn diagrams show DEGs in P4 back skin or 3-week-old back skin epidermis of mice (compared with mice that did not have hair/skin abnormalities). Among DEGs upregulated at both time points examined are Foxi3, Krt16, and Stfa2. ( ) Gene Ontology (GO) enrichment analysis of P4 back skin RNA-Seq data from mice versus control littermates. ( ) GSEA shows downregulated pathways in the back skin of P4 mice, as well as in the back skin epidermis of 3-week-old mice compared with mice. NES, normalized enrichment score. | yes |
PMC6749875 | Figure_7 | oa_package/67/6a/PMC6749875.tar.gz | ['Maxillary sulcus contour (mm) ().', '6Mentocervical angleMaxillary sulcus contour'] | Fig. 7 Maxillary sulcus contour | yes |
PMC8888474 | Figure_4 | oa_package/ec/9f/PMC8888474.tar.gz | [' 4) ist h ufig mit weiteren Endometrioselokalisationen assoziiert.', 'Endometriose des HarntraktesHarnblaseDie Endometriose der Harnblase ist die h ufigste Form der Endometriose des Harntraktes.'] | null | yes |
PMC8625462 | Figure_1 | oa_package/ff/24/PMC8625462.tar.gz | ['Examples of findings of the B-scan ultrasonic examination of two eyes from different patients are demonstrated in .', 'One of the most frequent posterior abnormalities (retinal detachment) is shown in a, and a rare finding (intraocular foreign body) is shown in b.', '1055/s-2004-82135816145582Findings of the B-scan ultrasonic examination.'] | Figure 1 Findings of the B-scan ultrasonic examination. ( ) Retinal detachment and ( ) an intraocular foreign body (white arrow). Posterior segment abnormalities were most commonly associated with posterior uveitis, followed by undetermined and posttraumatic cataracts. Other causes had relatively low incidences of posterior segment lesions, respectively ( ). | yes |
PMC8311012 | Figure_5 | oa_package/c8/0e/PMC8311012.tar.gz | [] | Figure4 Fluoroscopy Imaging Showing the Delivery Sheath and Watchman Device (Boston Scientific, Marlborough, Massachusetts) Fluoroscopy image in the RAO caudal view confirming the position of the delivery sheath in the left atrial appendage. Fluoroscopy image in the AP caudal view showing the Watchman device in the left atrial appendage. AP=anteroposterior; RAO=right anterior oblique; other abbreviations as in . | yes |
PMC7734537 | Figure_1 | oa_package/b5/52/PMC7734537.tar.gz | ['The nuclei are large and hyperchromatic with prominent nucleoli and an irregular nuclear membrane ().', '.', '1177_2374289520975173-fig1"/>What Are the Common Pathologic Types of Testicular Germ Cell Tumors?'] | Figure 1. Histologic features. A, Histology of normal seminiferous tubule (400). B, Histologic features of germ cell neoplasia in situ (GCNIS). The seminiferous tubules are small and atrophic with no active spermatogenesis. Neoplastic cells are present at the base of the seminiferous tubules. The large neoplastic cells have distinct borders, abundant clear cytoplasm, enlarged round nuclei, and prominent nucleoli (400). | yes |
PMC11374423 | Figure_7 | oa_package/e5/c9/PMC11374423.tar.gz | ['As shown in , the expression of NQO1, Nrf2, and HO-1 in the APP/PS1 model group was significantly decreased (p 0.', '006" position="float"/>Quercetin treatment enhanced the cognitive ability of APP/PS1 mice.'] | Figure 7 Quercetin treatment enhanced the cognitive ability of APP/PS1 mice. The data is represented as an average of SD. Compared with the normal control group mice, < 0.01. Compared with the APP/PS1 model group mice, < 0.01. | yes |
PMC10654338 | Figure_1 | oa_package/10/9c/PMC10654338.tar.gz | [' 1.', 'Representative autoradiographic and histopathological images.', 'Correlation between PSMA-ligand uptake, histopathology and immunohistochemistryHeterogeneity of PSMA IHC and PSMA-ligand uptakePSMA IHC was performed in 16 postoperative prostate specimens, one dropped out due to PIN.'] | Fig. 1 Representative autoradiographic and histopathological images. Autoradiographic image. HE staining image. prostate cancer. (C) PSMA IHC staining image. (D) Fused image of ARG and HE. ARG=autoradiography, HE=Hematoxylin and Eosin, IHC=immunohistochemistry, PSMA=prostate-specific membrane antigen. | yes |
PMC9375718 | Figure_1 | oa_package/36/e6/PMC9375718.tar.gz | ['The MRI showed a lesion with a size of 180x100x75 mm consisting of cystic components within the right vastus lateralis muscle ().', ':Preoperative magnetic resonance imaging sections of the intramuscular hydatid cyst before and after albendazole treatmentThe mass was reached by a 20 cm longitudinal skin incision on the right thigh anterolaterally.', 'According to the WHO-IWGE classification, the grade of CE appearance changed from CE2 to CE3b after albendazole treatment () (3).'] | Fig. 1: Preoperative magnetic resonance imaging sections of the intramuscular hydatid cyst before and after albendazole treatment | yes |
PMC11200790 | Figure_1 | oa_package/34/ff/PMC11200790.tar.gz | ['Under electron microscopy, these morphologically altered cells showed a stress-fiber-like cytoskeleton structure and extensive cytoplasm, suggesting that the hPDLSCs might differentiate into myofibroblasts (A,B).', '05), but COL1A1 and vimentin expression showed no significant difference (C).', '001) (D).', '1277329480623\nCharacteristics of fibroblast differentiation of hPDLSCs in vitro.'] | Figure 1 Characteristics of fibroblast differentiation of hPDLSCs in vitro. ( ) Spontaneous differentiation of periodontal ligament stem cells was observed in H-DMEM and -MEM medium. During in vitro culture, periodontal ligament stem cells changed from a spindle-like shape to a flat, broad shape with the increase in cell generations. Red arrows represent the shape-changed cells.( ) The 7th and 11th generation hPDLSCs were selected and stained with crystal violet. Under electron microscope, P7 showed a typical spindle morphology, and in the latter, the morphology tended to be the flat morphology of myofibroblasts. ( ) Expression and semi-quantitative analysis of the three proteins in different generations and in different mediums detected by WB. ( ) qPCR was used to detect the expression levels of myofibroblast differentiation-related genes (H-DMEM, -MEM, hPDLSCs, COL1A1: type 1 collagen 1 chain; -SMA, vimentin, = 3, ns > 0.05, * < 0.05, ** < 0.01, *** < 0.001). | yes |
PMC7479645 | Figure_3 | oa_package/28/f0/PMC7479645.tar.gz | ['Due to a significant defect in the aponeurosis, a polypropylene mesh was used ().', 'The use of a polypropylene mesh after R0 resection with significant defect in the aponeurosis.'] | Figure 3 The use of a polypropylene mesh after R0 resection with significant defect in the aponeurosis. | yes |
PMC4230418 | Figure_4 | oa_package/6e/43/PMC4230418.tar.gz | ['Non-lesional cases and controlsIn the five patients with acute cortical injuries following depth electrode studies, tracks lined by reactive inflammatory and granulation tissue were identified in the tissue resections.', 'Prominent labelling with both pS6 antibodies highlighted the injury site with labelling of cell types of mixed morphologies including neurones, astrocytes, macrophages around the electrode cavity as well as vascular endothelium ( 4A).', 'In one case (case 34), there were clear qualitative differences in the density of positive neuronal, glial and vascular labelling with both pS6 antibodies between the sample pairs ( 4B,C), but there were no clear differences between the samples in the three other cases.', 'A greater proportion of neurones were positive with pS6 (ser240/244) than pS6 (ser235/236), particularly in layers III and V, imparting a tramline labelling pattern in some cases ( 4D).', 'Striking perivascular neuronal positivity was also noted in the cortex in other cases with pS6 (ser235/236) ( 4E).', 'Labelling of small multipolar glia-like cells was more prominent with pS6 (ser235/236) in the white matter around vessels, in layer I and the subpial region ( 4F).'] | Figure 4 Intense labelling of morphologically different cells types, including macrophages and multipolar cells (inset), around an organising intracranial electrode track mark. ( and ) Paired samples from regions of different ictal activity, based on intracranial monitoring: is from case 34, sample 1 (ictal onset zone) where less pS6 labelling was seen with both markers (illustrated here with pS6 240/244) compared to sample 2 which represented less active/seizure spreading zone where more pS6 labelling of small cells was observed as well as neuronal cells (inset). Temporal lobe cortex with no specific pathology, adjacent to HS, where prominent tramline labelling of cortical neurones was observed with pS6 240/244. Another pathologically normal temporal lobe in epilepsy with a prominent perivascular labelling pattern of neuronal cells with pS6 235/236 (arrowhead) and labelling of small glial like cells around vessels in the white matter and inset in the subpial layer (inset). Bar in , , , , equivalent to approximately 50 microns and in d to 100 microns. | yes |
PMC5491487 | Figure_1 | oa_package/95/99/PMC5491487.tar.gz | ['He presented to the community hospital where the CT again showed an intra-abdominal abscess containing air within the mesentery mass ().', 'A (axial view) B (coronal view), left lower quadrant mesenteric mass containing fluid collection and air locules, measuring 6.', 'Following transfer, two additional abdominal drains were placed in an attempt to achieve infectious source control.'] | Fig. 1 A (axial view) B (coronal view), left lower quadrant mesenteric mass containing fluid collection and air locules, measuring 6.66.1cm and about the cephalad and lateral component 6.66.9cm. (long white arrow points to tumor, and short white arrow points to fistula track). | yes |
PMC4310207 | Figure_1 | oa_package/1b/26/PMC4310207.tar.gz | ['Histopathology revealed lesions in the liver (Stat1 / , b, c; heterozygous and WT mice, ', 'In the lungs, 73 % of the Stat1 / mice had evidence of pneumonia with focal to multifocal perivascular inflammatory cell infiltrates (d).', 'Phylogenetic analysis of MNV genomic nucleotide sequences showed MNV-O7 to cluster with MNV-O1 (isolated from a WT mouse in the same colony), on a branch separate from other MNV strains, but closely related to two German isolates (GV/CR18/2005/DEU and Berlin/05/O6/DE) and a South Korean isolate (MNV3/K4/2009/Korea) (a).', 'Phylogenetic analysis also showed CR18 to be related closely to MNV-O7 (a).', '0Syst Biol20105930732120525638HsuCCRileyLKWillsHMLivingstonRSPersistent infection with and serologic cross-reactivity of three novel murine norovirusesComp Med20065624725116941951HsuCCRileyLKLivingstonRSMolecular characterization of three novel murine norovirusesVirus Genes20073414715517171545H bscherSGHistological grading and staging in chronic hepatitis: clinical applications and problemsJ Hepatol199829101510229875653JohnsonRPAntigenic change in feline calicivirus during persistent infectionCan J Vet Res1992563263301335833KahanSMLiuGReinhardMKHsuCCLivingstonRSKarstSMComparative murine norovirus studies reveal a lack of correlation between intestinal virus titers and enteric pathologyVirology201142120221022018636KarstSMWobusCELayMDavidsonJVirginHWIVSTAT1-dependent innate immunity to a Norwalk-like virusScience20032991575157812624267KatpallyUWobusCEDrydenKVirginHWIVSmithTJStructure of antibody-neutralized murine norovirus and unexpected differences from viruslike particlesJ Virol2008822079208818094184LochridgeVPHardyMEA single-amino-acid substitution in the P2 domain of VP1 of murine norovirus is sufficient for escape from antibody neutralizationJ Virol200781123161232217804495MalmgaardLSalazar-MatherTPLewisCABironCAPromotion of alpha/beta interferon induction during in vivo viral infection through alpha/beta interferon receptor/STAT1 system-dependent and -independent pathwaysJ Virol2002764520452511932417ManuelCAHsuCCRileyLKLivingstonRSSoiled-bedding sentinel detection of murine norovirus 4J Am Assoc Lab Anim Sci200847313618459710McFaddenNAriasADryIBaileyDWitteveldtJEvansDJGoodfellowISimmondsPInfluence of genome-scale RNA structure disruption on the replication of murine norovirus similar replication kinetics in cell culture but attenuation of viral fitness in vivoNucleic Acids Res2013416316633123630317MohanRRMohanRRKimWJStarkGRWilsonSEDefective keratocyte apoptosis in response to epithelial injury in Stat 1 null miceExp Eye Res20007048549110865997MumphreySMChangotraHMooreTNHeimann-NicholsERWobusCEReillyMJMoghadamfalahiMShuklaDKarstSMMurine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responsesJ Virol2007813251326317229692NiceTJStrongDWMcCuneBTPohlCSVirginHWA single-amino-acid change in murine norovirus NS1/2 is sufficient for colonic tropism and persistenceJ Virol20138732733423077309NicklasWBaneuxPBootRDecelleTDeenyAAFumanelliMIllgen-WilckeBFELASA (Federation of European Laboratory Animal Science Associations Working Group on Health Monitoring of Rodent and Rabbit Colonies)Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental unitsLab Anim200236204211831737OldstoneMBViral persistence: parameters, mechanisms and future predictionsVirology200634411111816364742RadfordADTurnerPCBennettMMcArdleFDawsonSGlennMAWilliamsRAGaskellRMQuasispecies evolution of a hypervariable region of the feline calicivirus capsid gene in cell culture and in persistently infected catsJ Gen Virol1998791109460915RamanaCVGilMPSchreiberRDStarkGRStat1-dependent and -independent pathways in IFN-gamma-dependent signalingTrends Immunol2002239610111929133ShrestaSShararKLPrigozhinDMSniderHMBeattyPRHarrisECritical roles for both STAT1-dependent and STAT1-independent pathways in the control of primary dengue virus infection in miceJ Immunol20051753946395416148142SiebengaJJBeersmaMFVennemaHvan BiezenPHartwigNJKoopmansMHigh prevalence of prolonged norovirus shedding and illness among hospitalized patients: a model for in vivo molecular evolutionJ Infect Dis2008198994100118774885TaubeSRubinJRKatpallyUSmithTJKendallAStuckeyJAWobusCEHigh-resolution x-ray structure and functional analysis of the murine norovirus 1 capsid protein protruding domainJ Virol2010845695570520335262ThackrayLBWobusCEChachuKALiuBAlegreERHendersonKSKelleySTVirginHWIVMurine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergenceJ Virol200781104601047317652401TheiseNDLiver biopsy assessment in chronic viral hepatitis: a personal, practical approachMod Pathol200720Suppl 1S3S1417486049TomovVTOsborneLCDolfiDVSonnenbergGFMonticelliLAMansfieldKVirginHWArtisDWherryEJPersistent enteric murine norovirus infection is associated with functionally suboptimal virus-specific CD8 T cell responsesJ Virol2013877015703123596300WardJMWobusCEThackrayLBErexsonCRFaucetteLJBelliotGBarronELSosnovtsevSVGreenKYPathology of immunodeficient mice with naturally occurring murine norovirus infectionToxicol Pathol20063470871517074739WirtzSNeufertCWeigmannBNeurathMFChemically induced mouse models of intestinal inflammationNat Protoc2007254154617406617WobusCEKarstSMThackrayLBChangKOSosnovtsevSVBelliotGKrugAMackenzieJMGreenKYVirginHWReplication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophagesPLoS Biol20042e43215562321MNV phylogenetic tree including MNV-O7 and pathology caused by natural infection.'] | Fig. 1 MNV phylogenetic tree including MNV-O7 and pathology caused by natural infection. (a) Full-length genomic MNV nucleotide sequences were used to construct a maximum-likelihood phylogenetic tree with PhyML and 100 bootstrap interactions. The bootstrap values are indicated on the branches. Bar, 2 % nucleotide divergence. (bd) Representative pathology in liver (b, c) and lung (d) sections from naturally infected mice from which MNV-O7 was derived. (b) A focus of inflammation in the liver parenchyma that is magnified in (c) to show the presence of inflammatory cells (macrophages shown by the white arrow) and necrotic (black arrow) cells. (d) General infiltration of the lung; the arrow indicates a localized focus of inflammation associated with a bronchiole and blood vessel. Original magnification, 10 (b, d) and 40 (c). | yes |
PMC10662392 | Figure_1 | oa_package/66/5e/PMC10662392.tar.gz | [' 1A-C), with one of these two showing post contrast enhancement of the solid soft tissue component (', '\nWith a single submucosal stromal tumor.', 'CT scan in the arterial phase (B) and portal vein phase (C) showed the calcifications partially protruded into the gastric cavity, calcifications were surrounded by a few solid components, and no heterogeneous enhancement around the calcification foci\nWith a single submucosal stromal tumor.'] | Fig. 1 With a single submucosal stromal tumor. Unenhanced CT scan showed nodular calcifications under the mucosa of the gastric fundus. CT scan in the arterial phase ( ) and portal vein phase ( ) showed the calcifications partially protruded into the gastric cavity, calcifications were surrounded by a few solid components, and no heterogeneous enhancement around the calcification foci | yes |
PMC8141972 | Figure_3 | oa_package/32/84/PMC8141972.tar.gz | ['Mitoses were frequent (3 4 counts/10 high-power field), and focal coagulative necrosis was seen (A C).', 'The tumor cells were immunoreactive for vimentin, epithelial membrane antigen (EMA), S-100 protein, thyroid transcription factor 1 (TTF-1), and galectin-3 (D, E) and negative for glial fibrillary acidic protein.', '7% (F).', 'The neoplastic cells were linked by intermediate junctions and desmosomes (G).', 'Histopathologic findings.'] | Fig. 3 Histopathologic findings. (A) The tumor is composed of interlacing fascicles of spindle cells with abundant eosinophilic cytoplasm. (B) Focal nuclear pleomorphism and hyalinized stroma are seen. (C) Focal coagulative tumor necrosis is present. The tumor cells show immunoreactivity for galectin-3 (D) and thyroid transcription factor 1 (E). (F) The Ki-67 index was 26.7%. (G) Ultrastructural examination using paraffin-embedded tissue block show numerous mitochondria (white arrow) in tumor cell. | yes |
PMC11399706 | Figure_3 | oa_package/4a/90/PMC11399706.tar.gz | ['RE-JOIN clinical sites will also collect information about pain quality and location using RE-JOIN specific homunculus focused on anatomical orofacial and lower body sites ().', 'Homunculus for the RE-JOIN consortium clinical sites.'] | Fig. 3 Homunculus for the RE-JOIN consortium clinical sites. | yes |
PMC11074615 | Figure_7 | oa_package/1a/66/PMC11074615.tar.gz | ['In JEB, the level of cleavage occurs in the lamina lucida, while in DEB it occurs in the sublamina densa ().', 'Immunomapping of dominant dystrophic epidermolysis bullosa (DDEB).', 'Researching mutations in genes associated with EB is the reference technique for defining the EB subtype and would prevent the need for biopsy and immunomapping.'] | Figure 7 Immunomapping of dominant dystrophic epidermolysis bullosa (DDEB). Observe cleavage in the sublamina densa, with marker deposition and fluorescence on the roof of the bullae. The markers used are: (A) Bullous pemphigoid antigen, (B) laminin, (C) collagen IV and (D) collagen VII. | yes |
PMC7673361 | Figure_3 | oa_package/06/cb/PMC7673361.tar.gz | ['.'] | Fig. 3. (A) Timeline of experiments in which mice were subjected to isoproterenol-induced cardiac injury in conjunction with GW4869 exosome inhibition over 10days, followed by histological assessment of cardiac damage. (B) Exosome quantitation assays confirm inhibition of serum exosome levels. Data represent the means.e.m. Statistical significance was determined by a one-way ANOVA. =6 animals per group. * <0.05 day8 versus day0. (C) Representative images from heart sections subjected to Trichrome or Hematoxylin and Eosin (H&E) staining demonstrate isoproterenol-induced damage, which is mitigated by GW4869 exosome inhibition. (D) Quantitation of the percentage fibrotic area from H&E staining. Isoproterenol increases the percentage of cardiac fibrosis in mouse hearts versus myocardial area, and blocking exosome secretion with GW4869 reduces fibrosis. Data represent the means.e.m. Significance was determined using unpaired Student's -test. =6 animals per group; * <0.05 versus vehicle+isoproterenol. Scale bar: 12.7 mm. | yes |
PMC4177881 | Figure_6 | oa_package/23/7e/PMC4177881.tar.gz | ['Control mice had minimal numbers of CD3+ T cells in the liver, lungs, and heart, and a normal distribution of T cells in the spleen ( and <xref ref-type="supplementary-material" rid="pntd.', 'g006CD3+ T cell distribution in infected tissues.'] | 10.1371/journal.pntd.0003191.g006 | yes |
PMC3997226 | Figure_1 | oa_package/2f/6f/PMC3997226.tar.gz | ['Contraction and relaxation during force-length relationship in human right atrial cardiac muscles.'] | Figure 1 Preserved force-length relationship from 80 to 100% L in isolated isometric contracting right atrial cardiac muscles from non-diabetic (non-DM, closed circles, n=8) and type 2 diabetic (DM, open circles, n=6) patients. The contractile parameters, developed force (F , ) and maximum rate of contraction (+dF/dt , ) were not different between both groups. However, both relaxation parameters, minimum rate of relaxation (-dF/dt , ) and time constant of relaxation (Tau, ) were impaired in muscles from type 2 diabetic patients. Overall this indicates preserved contraction but impaired early and late relaxation in human diabetic right atrial myocardium with preserved LV ejection fraction. Two-way ANOVA: length effect: *=p<0.05 vs. 80% L for both non-DM and DM group; Group effect: #=p<0.05 vs. non-DM. Data are meanSEM | yes |
PMC11346804 | Figure_3 | oa_package/fe/20/PMC11346804.tar.gz | [] | Figure 3 The tumor cells that are diffusely positive for the MART-1 IHC study (40) MART-1: melanoma antigen recognized by T-cells 1; IHC:immunohistochemical | yes |
PMC6133455 | Figure_2 | oa_package/88/7b/PMC6133455.tar.gz | ['FDG-PET/CT scan, which was performed for the staging of a patient with squamous cell carcinoma type of NSCLC.'] | Figure 2 FDG-PET/CT scan, which was performed for the staging of a patient with squamous cell carcinoma type of NSCLC. | yes |
PMC8613214 | Figure_3 | oa_package/f2/b8/PMC8613214.tar.gz | [' 3B D).', ' 3F H).', 'Change in neurotransmitter levels has been associated with neurobehavioral phenotypes in PKU patients and mice.', ' 3B,D).', ' 3).'] | Figure 3 Restoration of brain neurotransmitter levels after PAH or PAL administration. Schematic of major steps involved in synthesis of neurotransmitters dopamine and norepinephrine. ( Dopamine precursor L-DOPA was significantly higher in PAL PAH and HET brains as compared to the nave PAH brains. Significant increases in dopamine and norepinephrine were observed in both the PAH and PAL PAH mouse brains as compared to the nave mice. Schematic of serotonin synthesis and downstream metabolite 5-hydroxyindolacetic acid (5-HIAA). Serotonin precursor 5-hydroxytryptophan , serotonin and 5-HIAA were all restored to levels similar to HET mice after PAH and PAL administration. N=5 per group were used for analysis. Control mice and mice treated with 1e11 vg/mouse of PAH or PAL vector were terminated on day 41 and perfused with PBS. Group abbreviations: PKU nave, untreated PAH mice; PKU PAH or PAL, treated PAH mice; HET, untreated HET mice. One-way ANOVA Tukeys multiple comparison, *p<0.05, **p<0.01, ***p<0.001 and ****p<0.0001. | yes |
PMC10360450 | Figure_2 | oa_package/6a/d6/PMC10360450.tar.gz | ['CT of the abdomen shows intraluminal hemorrhage or a mass and abrupt bowel caliber change in the vicinity of the hepatic flexure.'] | Figure 2 CT of the abdomen shows intraluminal hemorrhage or a mass and abrupt bowel caliber change in the vicinity of the hepatic flexure. The white arrow: an abrupt bowel caliber change in the vicinity of the hepatic flexure. | yes |
PMC5460005 | Figure_2 | oa_package/a4/78/PMC5460005.tar.gz | [':Intraoperative image after resection of skin, subcutaneous tissue, a portion of the right ear [E], upper and lower eyelids, peri-ocular muscles, bony orbital wall [O], a portion of the zygomatic bone [Z] and maxillary sinus [MS].'] | Figure 2: Intraoperative image after resection of skin, subcutaneous tissue, a portion of the right ear [E], upper and lower eyelids, peri-ocular muscles, bony orbital wall [O], a portion of the zygomatic bone [Z] and maxillary sinus [MS]. | yes |
PMC4933626 | Figure_2 | oa_package/49/8d/PMC4933626.tar.gz | [] | null | yes |
PMC7571377 | Figure_2 | oa_package/46/eb/PMC7571377.tar.gz | [' 2Fetal vascular malperfusionIntermediate-sized aggregate of villi, rimmed by preserved syncytiotrophoblasts, with total loss of villous capillaries and hyaline fibrosis of the stroma.'] | Figure2 Fetal vascular malperfusion Intermediate-sized aggregate of villi, rimmed by preserved syncytiotrophoblasts, with total loss of villous capillaries and hyaline fibrosis of the stroma. Well-vascularized villi are seen in the upper portion of the figure; a few are scattered in-between the avascular villi. H&E stain200. , hematoxylin and eosin. | yes |
PMC8389213 | Figure_6 | oa_package/85/8f/PMC8389213.tar.gz | ['Several blue dots indicating positive reaction with ferric iron were detected in the extracellular space and intracellularly in NaIO3-treated cells (A, panels 3 and 4).', 'A rare blue dot was also detected in control cells treated with vehicle (A, panels 1 and 2).', 'A similar evaluation of retinal sections from NaIO3-treated mice showed Perls positive vesicles in the space between the RPE and photoreceptor cell layer (B, panels 3 and 4).', 'No reaction was detected in vehicle-treated samples (B, panels 1 and 2).', 'Iron-loaded vesicles are released in the extracellular milieu by NaIO3 treatment.'] | Figure 6 Iron-loaded vesicles are released in the extracellular milieu by NaIO treatment. ( ) Staining with Perls reagent showed several blue dots intracellularly and extracellularly in NaIO -treated ARPE-19 cells (panel 3, arrowhead). Scale bar: 10 m. Boxed area is enlarged in panel 4. Scale bar: 10 m. A rare blue dot was also noted in control cells (panel 1, arrowhead). Boxed area is enlarged in panel 2. Scale bar: 10 m. ( ) Perls reaction of retinal sections from NaIO -treated mice showed a positive reaction in the space between RPE and PR cells (panel 3, arrowhead), better visualized in the enlarged boxed area (panel 4, arrowheads). Scale bar for panel 3: 10 m. Scale bar for panel 4: 10 m. RPE: retinal pigment epithelium; PR: photoreceptors; OS: outer segment of photoreceptors; IS: inner segment of photoreceptors; ELM: external limiting membrane; ONL: outer nuclear layer. | yes |
PMC2703824 | Figure_5 | oa_package/6f/02/PMC2703824.tar.gz | ['05, data not illustrated) and significantly reduced parasite load at the site of pathology (A, P 0.', '05, A).', 'No differences were observed in the draining lymph nodes (A).', 'g005Interfering with arginase-induced L-arginine metabolism restores CD4 T cell responses in nonhealer BALB/c mice.', 'As shown in B, five weeks post infection, BALB/c mice treated with L-arginine develop significantly smaller lesions and harbour less parasites in their lesions as compared to the untreated group.', 'We found that there was a significant increase in the capacity of CD4 T cells from the lesions of BALB/c mice treated with L-arginine both to proliferate and express IFN- as compared to the untreated group (C).'] | 10.1371/journal.pntd.0000480.g005 | yes |
PMC3003672 | Figure_1 | oa_package/d9/45/PMC3003672.tar.gz | ['Examples of incidental findings observed on CT pulmonary angiograms.', 'a: coronary calcification, b: right ventricular mural thrombus.', 'c: aortic wall calcification.'] | Figure 1 . Figure 1a: coronary calcification, Figure 1b: right ventricular mural thrombus. Figure 1c: aortic wall calcification. | yes |
PMC1820987 | Figure_5 | oa_package/a6/b8/PMC1820987.tar.gz | ['Immunostained M.'] | Figure 5 Immunostained antigen in alveolar macrophages (one is arrowed) and free in alveoli (arrow-head). Control goat (culture positive) for immunohistochemistry. StreptABC/HRP, 504. | yes |
PMC11390214 | Figure_2 | oa_package/51/fc/PMC11390214.tar.gz | ['Upon entering the peritoneal cavity, approximately 500 cc of milky fluid was evacuated from the upper abdomen ().', '001" position="float"/>Milky fluid was evacuated from the upper abdomen.'] | Figure 2 Milky fluid was evacuated from the upper abdomen. | yes |
PMC8356707 | Figure_9 | oa_package/57/62/PMC8356707.tar.gz | ['Images appeared more basophilic in DPS4, whereas they were more eosinophilic in DPS3 [].', 'Photomicrograph of resection margin of intestine, depicting wide variation in the color of the image by various digital pathology systems ( 2): digital pathology system 1 (a), digital pathology system 2 (b), digital pathology system 3 (c), and digital pathology system 4 (d)Based on the mean score of the participating pathologist, level of confidence for digital reporting was highest for DPS1 followed by DPS2 for biopsy, resection, and frozen section cases.'] | Figure 9 Photomicrograph of resection margin of intestine, depicting wide variation in the color of the image by various digital pathology systems (2): digital pathology system 1 (a), digital pathology system 2 (b), digital pathology system 3 (c), and digital pathology system 4 (d) | yes |
PMC4122966 | Figure_6 | oa_package/cc/ed/PMC4122966.tar.gz | ['b-wave amplitudes of dark-adapted electroretinograms in non-treated wild-type mice mostly remained unchanged or slightly increased at the age of 33 days (Supplementary a).', 'Note that KUS administration in adult wild-type mice did not induce any significant change in the amplitude of a- and b-waves (Supplementary b and c).', 'When examined by electron microscopy, the outer segment of the control mouse retina was mostly disarranged at the age of 21 days (a and c), whereas that of KUS-treated mouse retina was regularly arranged (', 'org/1999/xlink" xlink:href="srep05970-f5"/>KUSs preserved retinal microstructures in the rd10 mouse model of retinitis pigmentosa.'] | Figure 6 KUSs preserved retinal microstructures in the rd10 mouse model of retinitis pigmentosa. Electron micrographs of 21-day-old rd10 mice, administered saline (a, c) or KUS187 (b, d). RPE, retinal pigment epithelium. Note that morphologies of outer segments of retinas in KUS-treated rd10 mice were well preserved but most of the outer segments in saline-treated control rd10 mice were degenerated. OS in (c) and (d) indicates morphologically intact outer segment, and dOS in (c) morphologically degenerated outer segment. Scale bars: 5m in (a) and (b); 500nm in (c) and (d). | yes |
PMC10442368 | Figure_3 | oa_package/95/f4/PMC10442368.tar.gz | ['2 cm in the right atrium, normal biventricular systolic function, and no obstruction of the tricuspid valve ( 3; Videos 1 and 2).', ' 3(A) Two-dimensional TTE, apical four-chamber view, systolic frame, demonstrating a large mass in the right atrium (arrows).'] | Figure2 Contrast-enhanced CT of the chest reported to be performed as a pulmonary arterial embolism protocol was obtained to rule out pulmonary embolism. It shows a large solid mass in the right atrium in the axial, coronal, and sagittal planes. | yes |
PMC8146351 | Figure_1 | oa_package/47/fe/PMC8146351.tar.gz | ['In addition, treatment with CeO2NPs increases transcription factor NF-kB activation by decreasing the IKB expression ().', '1039/C4RA12007H(a) Rats received vehicle or 1 g/kg acetaminophen (APAP) after CeO2NP treatment.'] | Figure 1 ( ) Rats received vehicle or 1 g/kg acetaminophen (APAP) after CeO NP treatment. The top panels show hematoxylin-eosin stained liver sections. The bottom panels show immunostaining for Ki-67 (green) used as a marker of hepatocellular proliferation. Magnification: 100. ( ) Western blot for IB expression in the HepG2cell line treated with vehicle or CeO NP. ( ) Transcription factor immunosorbent assay for p65 activity in the cell line HepG2 treated with vehicle or CeO NP (adapted from reference [ ]). | yes |
PMC5028983 | Figure_1 | oa_package/7f/95/PMC5028983.tar.gz | [' 1a).', ' 1b).', 'Clinical photographs prior to and during treatment with immune checkpoint inhibition.', 'There is increased confluence of existing lesions, as well as new hyperpigmented papules on the bilateral upper arms and the neckRadiologic findingsThe PET/CT on 11/20/15, four days after the first dose of ipilimumab/nivolumab, showed no remarkable areas of FDG avidity ('] | Fig. 1 Clinical photographs prior to and during treatment with immune checkpoint inhibition. Panel shows a photograph of the chest from 10/5/15 prior to initiation of pembrolizumab, with numerous hyperpigmented papules and plaques scattered across the chest. Panel shows a photograph of the chest from 2/23/16, after completing ipilimumab/nivolumab induction. There is increased confluence of existing lesions, as well as new hyperpigmented papules on the bilateral upper arms and the neck | yes |
PMC6856500 | Figure_1 | oa_package/60/37/PMC6856500.tar.gz | ['Initial percutaneous transhepatic cholangiogram (PTC) from the left biliary duct confirmed the long segment stricture involving the confluence of the right and left main hepatic ducts ().', 'Initial magnetic resonance cholangiopancreatography and cholangiogram demonstrating biliary stricture and dilatation of intrahepatic bile ducts.'] | Fig. 1 Initial magnetic resonance cholangiopancreatography and cholangiogram demonstrating biliary stricture and dilatation of intrahepatic bile ducts. | yes |
PMC5595787 | Figure_1 | oa_package/9f/99/PMC5595787.tar.gz | [' 1A).', ' 1B), suggesting that ATE1 truly favors -syn as a substrate.', 'Notably, in these in vitro assays arginylation occurred on the full length protein and not proteolytically derived fragments (Figs 1 and 2).', ' -syn is arginylated in vitro.', '\n -syn is arginylated in vivo.'] | Figure 1 -syn is arginylated . ( ) arginylation of purified preparations of human tau, -syn, and TDP-43 using radioactively labeled [ C-Arg] and detected by SDS PAGE (top) and autoradiography (bottom). The lines underneath the lanes list the components added to each reaction. ( ) arginylation of human and mouse -syn. Top, Coomassie stained gel. Bottom, autoradiograph. | yes |
PMC3694096 | Figure_4 | oa_package/e9/7e/PMC3694096.tar.gz | ['As summarized in \n\n, both inhibitors occupy the active site, engage the hinge region peptide backbone at Met109, and occupy the nearby hydrophobic pocket.', 'g004Crystal structures of human p38 MAPK with MW108 (PDB 4F9W) or MW181 (PDB 4F9Y) bound in the active site.'] | 10.1371/journal.pone.0066226.g004 | yes |
PMC3169362 | Figure_1 | oa_package/1f/b9/PMC3169362.tar.gz | ['The panoramic radiograph revealed no important alterations in the mandible ().', 'A prop sito de um caso cl nicoCient Dent200742172215CamposPSFDepress o ssea de Stafne: ocorr ncia bilateral e bilocularRPG Revista da P s-Gradua o2006132362406CamposPSFPanellaJCruso -RebelloIMAzevedoRAPenaNCunhaTMandibular ramus-related Stafne s bone cavityDentomaxillofacial Radiology20043316366151408257MinowaKInoueNSawamuraTMatsudaATotsukaYNakamuraMEvaluation of static bone cavities with CT and MRIDentomaxillofacial Radiology200332127128208468CamposPSFEvaluation of the relation between the salivary submandibular gland and the posterior variant of Stafne bone defectJournal of Oral and Maxillofacial Surgery2007632359TurtelliCMCostaPPSSilvaHSLLipoma Paraosteal de Arco Costal: relato de casoRadiologia Brasileira200538317319Panoramic radiograph did not reveal bone defects in the mandible.'] | Figure 1 Panoramic radiograph did not reveal bone defects in the mandible. | yes |
PMC8826390 | Figure_3 | oa_package/78/2c/PMC8826390.tar.gz | ['s 3 and 4 show representative cases for the predictions of the model.', 'A 68-year-old female with known hypertension (The images were created by the authors using open-source software, Matplotlib v3.', 'A 71-year-old man with a recent history of head trauma (The images were created by the authors using open-source software, Matplotlib v3.'] | Figure 3 A 68-year-old female with known hypertension (The images were created by the authors using open-source software, Matplotlib v3.5, Python v3). A right thalamic hematoma extended into the adjacent ventricular system on a non-contrast head CT scan (right). NormGrad (middle) method generates more delicate saliency maps than Grad-CAM (left), highlighting the thalamic hematoma and its ventricular extension. The average quality scores were 3.6 points and 2 points for the NormGrad and Grad-CAM, respectively. Please note that the observers evaluated saliency maps with the same color spectrum, and the current color maps are adjusted for representative purposes. | yes |
PMC11379749 | Figure_4 | oa_package/8d/b5/PMC11379749.tar.gz | ['396 402, with permission from Elsevier) [35]Table 3A Comparison of Revised Duke Criteria for Diagnosis of Infective EndocarditisCRITERIA20002023PATHOLOGICMicroorganism IdentificationMicroorganisms demonstrated by culture or histologic examination of a vegetation, vegetation that has embolized, or an intracardiac abscess specimenVegetation or intracardiac abscess confirmed by histologic examination showing active endocarditisMicroorganisms identified in appropriate sample by PCR, amplicon or metagenomic sequencing, or in situ hybridizationMAJOR CLINICAL CRITERIAMicrobiologyBlood culturesAt least 2 positive cultures of blood samples drawn 12 h apart; or all of 3 or a majority of 4 separate cultures of blood (with first and last sample drawn at least 1 h apart)Removed requirements for timing and separate venipunctures for blood culturesDefinition of typical organismsViridans streptococci, Streptococcus bovis, HACEK group, Staphylococcus aureus; or Community-acquired enterococci, in the absence of primary focusAdded typical pathogens:1) S.'] | Fig.4 Two cases of right-sided IE confirmed by PET/CTA. A 37-year-old woman with a repaired pulmonary atresia and ventricular septal defect (VSD) (no 3). She had fever and positive blood cultures for Staphylococcus epidermidis, 1.1years after her last surgery, which consisted on right ventricle to pulmonary artery homograft replacement. ECHO findings were inconclusive for a vegetation on the VSD patch. PET/CTA performed 3days later showed a large (3cm) vegetation on the pulmonary homograft ( ) that was markedly hypermetabolic (SUVmax 9.93) in the fusion images, thus confirming IE ( ). Another case of a 43-year-old man with tetralogy of Fallot-type CHD (no 12) who had early Staphylococcus epidermidis IE of a bioprosthetic pulmonary valve (Carpentier Magna) 7months after his fifth surgery. PET/CTA showed pulmonary vegetations and a periprosthetic abscess with a SUVmax of 19.28 ( ) associated with septic pulmonary embolisms. He also had a right ventricular outflow tract enlargement patch of pericardium ( ), a Teflon VSD patch ( ), and Dacron pulmonary artery plasties. None of them showed pathological FDG uptake or anatomical abnormalities. (Reprinted from: Pizzi, M.N., et al. Int J Cardiol, 2017. 248: p. 396402, with permission from Elsevier) [ ] | yes |
PMC8345115 | Figure_3 | oa_package/db/3d/PMC8345115.tar.gz | [' shows representative images of the super-resolution reconstruction images (right) alongside the widefield images of nuclei from either carcinoma cells of the tumour region within a colorectal carcinoma tissue (D), or from normal epithelial, submucosa-derived stromal cells, and muscle cells of the muscle layer of corresponding normal colorectal tissue, respectively (A C).', 'The total number of blinking signals for each one of the reconstructed images shown in is 0.', 'This heterogeneity, however, became much more pronounced in the super-resolved images (, , and ).', 'Representative SMLM images of normal colorectal cell nuclei (normal epithelial cell of normal mucosa, submucosa-derived stromal cell, smooth muscle cell within muscular layer) within normal colorectal tissue specimen (A C), and of a carcinoma cell nucleus (D).'] | Figure 3 Representative SMLM images of normal colorectal cell nuclei (normal epithelial cell of normal mucosa, submucosa-derived stromal cell, smooth muscle cell within muscular layer) within normal colorectal tissue specimen ( ), and of a carcinoma cell nucleus ( ). Widefield images ( ) and SMLM reconstructions ( ) of nuclei imaged from human colorectal tissue sections. Scale bars: 3 m. | yes |
PMC8698437 | Figure_7 | oa_package/43/1d/PMC8698437.tar.gz | ['Central to DP is Whole Slide Imaging (WSI), Slides are scanned and converted to digital file that can be viewed on specialised software with quick and easy retrieval at future timepoints at different locations, as required ().', 'Whole Slide Imaging.'] | Figure 7 Whole Slide Imaging. A virtual slide tray of a given case with multiple horizontal and vertical sections. | yes |
PMC5070838 | Figure_6 | oa_package/3c/12/PMC5070838.tar.gz | ['Five years later, physical examination revealed cervical lymph nodes; Neck ultrasound reported a suspected malignancy cervical lymph node () and the fine needle aspiration (FNA) revealed a papillary carcinoma.', ''] | Fig. 6 Neck ultrasound. Lymph nodes with heterogenous echotexture, mixed (central/peripheral) blood vessels, located in left cervical levels IIA, IIB, III and IV. | yes |
PMC2831184 | Figure_2 | oa_package/c0/52/PMC2831184.tar.gz | [' 2a), small plaque-like accumulations of plasma proteins, lymphocytes and macrophages (microatheroma) [31, 67].', ' 2b f) termed lipohyalinosis.', ' 2g) [67] termed arteriolosclerosis.', ' 2h i).', '', '2003 [129] with kind permission\nSVD is first seen in the arteries of the basal ganglia, mainly in the putamen and the globus pallidus, which exhibit small vessel AS and lipohyalinosis.', ' 2c e, h, j).', ' 2, 4a).'] | Fig.2 Small vessel disease-related changes. A leptomeningeal artery shows intima proliferation and a splitting of the internal elastic lamina ( ). These changes are related to small vessel arteriosclerosis/atherosclerosis. A white matter artery exhibits fibrosis, lipohyalinosis of the vessel wall, and fibrinoid necrosis ( ). Lipohyalinosis affected vessels exhibit the plasma proteins apoE ( ), A2M ( ), and IgG ( ) within the vessel wall ( in ) indicating the leakage of plasma proteins into the vessel wall and into the perivascular space ( in ). Macrophages within the lipohyalinotic lesions and perivascular astrocytes strongly exhibit the A2M and apoE receptor LRP (CD91) ( ) indicating that these cells are capable of taking up A2M and apoE. Arteriolosclerosis of a white matter artery shows severe hyalinization ( ) of the vessel wall. ApoE and A2M were observed within the vessel wall of arteriolosclerotic vessels ( in , ). Within the enlarged perivascular spaces high numbers of apoE ( ), A2M ( ), and LRP-positive cells ( in ) were observed indicating that these perivascular cells accumulate apoE and A2M due to an insufficient perivascular drainage. These perivascular macrophages are often Prussian blue negative and do not necessarily represent hemorrhagic residues [ ]. Stainings in as indicated. Anti-apoE and anti-A2M staining was performed as indicated in Fig. . For anti-IgG and anti-LRP immunohistochemistry the following antibodies were used [anti-IgG: polyclonal goat; Biomeda, Foster City, CA; 1/100; microwave pretreatment; anti-LRP (anti-CD91): 2-M-R-II2C7; BioMac, Leipzig, Germany; 1/150; microwave and protease pretreatment]. The calibration bar in corresponds to: 300m, 80m, 40m, , 35m, , 60m, 20m, 16m, 50m. and are reproduced from Thal et al. 2003 [ ] with kind permission | yes |
PMC10655395 | Figure_7 | oa_package/d4/92/PMC10655395.tar.gz | [' 7A and 8A).', ' 7B, C and 8B, C).', 'Cyanidin-3-O-glucoside (C3G) attenuated neuronal apoptosis and tau protein phosphorylation in the cortex of APPswe mice.', 'Bars represent mean SECyanidin-3-O-glucoside (C3G) attenuated neuronal apoptosis and tau protein phosphorylation in the hippocampus of APPswe mice.', ' 7D, E and 8D, E).', ' 7F G and 8F G).', ' 7H and 8H).'] | Fig. 6 Cyanidin-3-O-glucoside (C3G) regulates neuroinflammation and antioxidation in APPswe mice. Mice were divided into three groups: non-transgenic mice (NC), AD mice orally administered PBS (APPswe), and AD mice orally administered 30mg/kg/day C3G in PBS (APPswe_C3G). The mRNA expression levels of pro-inflammatory cytokines, such as interleukin (IL)-1, tumor necrosis factor- (TNF-), and interleukin (IL)-6, in the cortical ( ) and hippocampal regions of the brain ( ) were observed using RT-PCR (n=5). The levels of ( ) TNF- and ( ) IL-6 and antioxidants ( ) catalase (CAT) and ( ) glutathione peroxidase (GSH-Px) were observed in the serum using ELISA (n=5). Data are representative of three independent experiments with similar results. * <0.05, ** <0.01, *** <0.001, **** <0.0001. Bars represent meanSE | yes |
PMC8382268 | Figure_13 | oa_package/c9/59/PMC8382268.tar.gz | [] | Figure 10 CTA (A) 6 months after the initial surgery, (B) 1 month after the stage 1 procedure and (C) 3 months after the final procedure. The total size of the aortic arch had reduced because of shrinkage of the false lumen. Reduced contrast leak is visualised on (B) and (C). CTA, CT angiography. | yes |
PMC6291399 | Figure_2 | oa_package/36/07/PMC6291399.tar.gz | ['As sequelae of mandibular division of the trigeminal nerve (V3) involvement by the tumor, chronic denervation atrophy of the medial and lateral pterygoid, masseter and temporalis muscles, and atrophy of the parotid gland were evident on the left side (\nA\n).', 'org/1999/xlink" xlink:href="10-1055-s-0038-1676455-i180003-1"/>\nPostoperative coronal T1-weighted image with fat saturation (\nA\n) demonstrates typical imaging characteristics of HB with serpentine flow voids.', 'Three-month postoperative MRI showed slightly increased size of the residual mass with increased multilocular cystic component and newly visualized multiple flow voids of enlarged feeding vessels (\nB\n).'] | Fig. 2 Postoperative coronal T1-weighted image with fat saturation ( ) demonstrates typical imaging characteristics of HB with serpentine flow voids. The mass incompletely encases and medially displaces the cavernous portion of the left internal carotid artery ( ). The mass exhibits inferolateral extension into the ipsilateral foramen ovale (white arrow; ) and a nodular projection to the vicinity of the optic tract superiorly. Coronal T2-weighted image ( ) reveals the sequelae of CN V3 involvement by the tumor with advanced chronic denervation atrophy with fatty replacement of the left medial and lateral pterygoid, masseter and temporalis muscles (white arrowheads; ). CN, cranial nerve; HB, hemangioblastoma. | yes |
PMC10681000 | Figure_2 | oa_package/ba/56/PMC10681000.tar.gz | [] | FIGURE 2 Colorectal endoscopic submucosal dissection of a lateral spreading tumorG mixed type with highgrade dysplasia: (a) white light image, (b) linked color imaging, (c) bluelight imaging, (d) bluelight imagingwith low magnification Japan narrow band imaging expert team 2B area, (e) Submucosal dissection, and (f) pinned specimen. | yes |
PMC10661120 | Figure_5 | oa_package/d2/67/PMC10661120.tar.gz | ['Specifically, the presence of Drp1 and Fis1 proteins increased, while the protein levels of Mfn1, Mfn2, and OPA decreased compared to the control cells (A and B).', 'Additionally, Drp1 and Mfn2 fluorescence intensities were comparable to the quantitative evaluations of immunoblot (C, D, and 5E).', 'Reduction of mitophagy was regarded after counting cells with punctate LC3-II appearance (C and F).', 'WB also showed a reduced protein level of mitophagy-related proteins (LC3-II, Beclin-1, Atg5, Atg7, and others), and these proteins were reduced in cells subjected to HG conditions (G and H).', 'Finerenone attenuates HG-induced mitochondrial dynamics and abnormal mitophagy in HK-2 cells.', ''] | Fig. 4 (A) HK-2cells were immuno-stained to show the localization of NR3C2 (green) and p-AKT (red). Scale bar: 10m. (CI) By immunoblotting, the presence of NR3C2 and KIM-1 were increased under HG ambience, but AKT was unaffected. Expressions of PI3K, p-AKT, and eNOS were decreased. Concurrently, the expression and activity of the PI3K/Akt/eNOS pathway and KIM-1, a marker of renal tubular injury, were markedly increased in the HK-2cells treated with finerenone. Interestingly, the overactivation of MR was also reversed (n=3). Data are shown as meansSEM; * <0.05 the NG group, <0.05 . the HG group. | yes |
PMC7754598 | Figure_2 | oa_package/bb/27/PMC7754598.tar.gz | [' 2a and Additional file 3: S2c).', ' 2b and ', ' 2c).', ' 2d).', '', '01Since mitochondrial OXPHOS besides the tricarboxylic acid (TCA) cycle is the main source of energy in neurons, we measured the intracellular ATP concentrations in WT and SMA MNs.', ' 2e).', ' 2f and Additional file 3: S2 g).', ' 2g).'] | Fig.2 Defective mitochondrial complex I causes cellular dysfunction in SMA MNs. Complex I activity using 20g mitochondria extract isolated from WT and SMA MNs (10DIV) (N=4). Quantification represents the increase in mean OD nm/h. Representative images and quantification of WT and SMA MNs labeled with CellROX (green and rainbow color) for ROS detection, DAPI (blue), and Phalloidin (red). Rainbow color indicates the intensity of CellROX signal. Quantification of mean fluorescence intensity of the CellROX signal in WT and SMA MN (red squares) (n=40, N=4). Scale bars are written on individual images. Quantification of CellROX signal of WT and SMA MNs measured with a microplate reader (N=5). Western blot analysis and quantification of carbonylated proteins (DNP=2,4-dinitrophenyl) in 10DIV WT and SMA MNs (N=4). Bar graph represents the quantification of the DNP signal. ACTB was used as a loading control. ATP levels in WT (N=7) and SMA MNs (N=8). Data are normalized to solubilized protein amounts. ATP levels in WT and SMA MNs (N=6) after 50mM pyruvate treatment for 1h. Data are normalized to solubilized protein amounts. Individual data (circle or square) represent biological replicates. ROS levels of SMA MNs after 50mM pyruvate or 100M menadione treatment for 1h. Two-tailed unpaired t-tests with Holm-Bonferroni correction for multiple comparisons were used on independent biological replicates (N=6) to determine statistical significance. * <0.05, ** <0.01. Blue circles represent data from WT and red squares represent SMA MNs. 10DIV MNs were used. Each dot represents the quantification of individual biological replicates. A two-tailed unpaired t-test was used on independent biological replicates to determine statistical significance. Bar graphs depict the meanS.D., n.s. >0.05, * <0.05, ** <0.01 | yes |
PMC9583263 | Figure_6 | oa_package/a9/62/PMC9583263.tar.gz | [] | Figure6 Severe disease is associated with severe CD8 T cell depletion. Flow cytometry analysis of the proportions of CD3 T cells and CD8 cells comparing healthy uninfected control chickens to susceptible and resistant chickens. Cytokine expression analysis as determined by qPCR, in the lung and spleen of chickens infected with the NP 373T bearing variant of A/Anhui/1/13 (H7N9) compared chickens infected with the NP 373A bearing variant of A/Anhui/1/13 (H7N9). Error bars represent SEM. *p<0.05, **p<0.01. | yes |
PMC7713670 | Figure_4 | oa_package/af/74/PMC7713670.tar.gz | ['4a).', 'Scale bars = 100 mIn agreement with previous studies, significantly elevated IBA1 immunoreactivity was also present in the cortex of TMEV-infected mice compared to PBS-injected controls at both 4 dpi (p = 0.'] | Fig. 4 TMEV-injected animals exhibit scarring and reactive NG2 cells and microglia/macrophages in the hippocampus at 14 dpi. NG2 cells (green) and microglia/macrophages (red) in the CA1 region of the hippocampus of PBS-injected (top) and TMEV-injected (bottom) mice at 14 dpi. TMEV-injected mice showed significantly greater immunoreactivity for NG2 compared to PBS-injected mice. TMEV-injected mice showed significantly greater immunoreactivity for IBA1 compared to PBS-injected mice. Images are 20 maximum-intensity projections of 12m confocal z stacks. Scale bars = 100m | yes |
PMC3851064 | Figure_2 | oa_package/90/de/PMC3851064.tar.gz | ['(a) Enterocele at ECCD: correctly identified also at MR-Defecography(b).'] | Figure 2 . | yes |
PMC7863388 | Figure_7 | oa_package/95/dd/PMC7863388.tar.gz | [] | Figure 4 CSF1R expression in endothelial cells and macrophages affects response to amyloid injection | yes |
PMC6745074 | Figure_2 | oa_package/64/9d/PMC6745074.tar.gz | [' 2).', 'c Contrast-enhanced sagittal MR T1-weighted image with fat saturation illustrating significant enhancement of C5 6 vertebrae marrow with no enhancement of the anterior disc (white arrow), and spinal dural thickening and enhancement (red arrow)TimelineThe timeline for the development of this case is summarized in '] | Fig. 2 Magnetic resonance (MR) imaging findings in the patient. Sagittal MR T1-weighted image of the cervical spine showing the normal bone marrow and endplates signal disappeared and replaced by diffused low-signal intensity of the C5 and C6 vertebrae. Sagittal short time inversion recovery (STIR) MR image illustrating the same diffused high signal intensity of the C56 disc (white arrow), the waved erosion and destruction of both adjacent C56 endplates (red arrows), and the swelling of prevertebral soft tissue. Contrast-enhanced sagittal MR T1-weighted image with fat saturation illustrating significant enhancement of C56 vertebrae marrow with no enhancement of the anterior disc (white arrow), and spinal dural thickening and enhancement (red arrow) | yes |
PMC3515949 | Figure_4 | oa_package/a3/2d/PMC3515949.tar.gz | ['The artery feeding the adenoma tends to branch around the periphery of the gland before penetrating deeper, resulting in a characteristic arc or rim of vascularity [].', 'Longitudinal ultrasound image of a 3-cm oval-shaped, multiloculated nodule in the upper parathyroid.'] | Figure 4 Longitudinal ultrasound image of a 3-cm oval-shaped, multiloculated nodule in the upper parathyroid. Power-Doppler shows peripheral pattern of vascularity (white arrow). | yes |
PMC4091167 | Figure_5 | oa_package/dc/af/PMC4091167.tar.gz | [] | null | yes |
PMC10482020 | Figure_1 | oa_package/84/4a/PMC10482020.tar.gz | ['6)Clinical photograph of lichen planus on the left side of the buccal mucosaClinical photograph of lichen planus on the right side of the buccal mucosaClinical photograph of lichenoid reaction ventral surface of the tongueClinical photograph of periodontitisClinical photograph of malignancy involving the buccal mucosaThe majority of patients had full dentition, followed by partially edentulous and completely edentulous [Table 4].'] | Figure 1 Clinical photograph of lichen planus on the left side of the buccal mucosa | yes |
PMC6257807 | Figure_1 | oa_package/6b/7e/PMC6257807.tar.gz | ['The number of nodules or masses was 2 4 in 13 patients, 5 7 in 5 patients and 8 10 in 2 patients ().', 'HE staining indicated that Cryptococcus neoformans-infested lesions were engulfed by macrophages (), and around them, a larger number of infiltrating lymphocytes were present, which formed multinucleated macrophages or granulomas, which were at times accompanied by coagulative necrosis.', 'Curr Med Res Opin4Suppl 291112013.'] | Figure 1. (A) Computed to mography scans of various cases of primary pulmonary cryptococcosis exhibiting multiple intrapulmonary nodules and round satellite lesions distributed along the bronchial tract (two upper panels). (B) HE staining indicated that was engulfed by macrophages, which were surrounded by massive infiltrating lymphocytes and a large amount of fibrous tissue, which formed multinucleated macrophages or granulomas (left lower panel, magnification, 400). (C) Periodic acid-Schiff staining indicated a large number of purple-red within multinucleated macrophages (middle lower panel magnification, 400). (D) Giemsa staining indicated a large number of black (right lower panel magnification, 400). | yes |
PMC11099496 | Figure_4 | oa_package/ac/f7/PMC11099496.tar.gz | ['A lesion on the left anterior thigh is seen before (4A) and after (4B) one treatment with pulsed dye laserDiscussionThe composition and cell morphology of dermal microvasculature are known to be altered in inflammatory skin diseases, cutaneous neoplasms, and chronological aging.'] | Figure 4 A lesion on the left anterior thigh is seen before (4A) and after (4B) one treatment with pulsed dye laser | yes |
PMC6685413 | Figure_1 | oa_package/14/5e/PMC6685413.tar.gz | ['CAG revealed two giant CAAs in the right coronary artery (RCA) (figure 1).', 'Coronary angiography revealing giant aneurysm ( ) in right coronary artery.'] | Figure 1 Coronary angiography revealing giant aneurysm () in right coronary artery. | yes |
PMC4660494 | Figure_5 | oa_package/ba/bd/PMC4660494.tar.gz | [] | Figure 5 Computed tomography scan of first patient showing dilated intestinal loops | yes |
PMC11329182 | Figure_5 | oa_package/87/8d/PMC11329182.tar.gz | [] | FigureE2 Axial magnetic resonance imaging showing the para-aortic mass. | yes |
PMC1282581 | Figure_2 | oa_package/7c/5e/PMC1282581.tar.gz | ['A.', 'B.'] | Figure 3 The graph shows the invasion assay results for each cell line with experimental conditions. The blue bar for each represents the control proliferation without Imatinib Mesylate, and the red bar with the compound. A statistical difference was seen for the five cell lines after 10 M exposure. | yes |
PMC5815426 | Figure_7 | oa_package/96/f6/PMC5815426.tar.gz | ['A -treated Tc1 mice, the two-way ANOVA showed a genotype effect only for Bcl-W ((c) and (e)) but no change for other pro- or anti-apoptotic proteins compared to Sc.', 'A -treated WT mice ((a), (b), (d)).', '.', '1177_0269881117743484-fig7"/>In the hippocampus, A 25-35 injection significantly increased both pro-apoptotic proteins Bax ((a) and (e)) and Bim ((b) and (e)) in WT mice and failed to affect the anti-apoptotic markers Bcl-W ((c)) and Bcl-XL ((d)).'] | Figure 7. Analyses of apoptotic pathway in the cortex of Tc1 mice injected with amyloid- [25-35] (A ) peptide. Wildtype (WT) or Tc1 mice were administered intracerebroventricular (i.c.v.) injections with scrambled peptide (Sc.A) or A peptide (9 nmol) and sacrificed 10 days after injection. The levels of pro-apoptotic proteins, Bax (a) and Bim (b), and anti-apoptotic proteins, Bcl-W (c) and Bcl-XL (d), were assessed by Western blot in the cortical protein lysates. Typical blots are shown in (e). The number of animals per group is indicated below the columns. Two-way analysis of variance (ANOVA): =0.477, 0.05 for the genotype, =4.43, 0.05 for the treatment, =4.54, 0.05 for the interaction in (a); =0.302, >0.05 for the genotype, =0.649, >0.05 for the treatment, =1.40, >0.05 for the interaction in (b); =10.2, 0.01 for the genotype, =1.33, 0.05 for the treatment, =0.432, 0.05 for the interaction in (c); =12.3, 0.01 for the treatment, =0.181, 0.05 for the genotype, =0.719, 0.05 for the interaction in (d). * 0.05; ** 0.01 vs same genotype Sc.A-treated mice; # 0.05 vs same treatment WT mice; Bonferronis test. | yes |
PMC2838224 | Figure_2 | oa_package/6b/fe/PMC2838224.tar.gz | ['001"/>Assial CT scan showing the tumor (arrow).'] | Figure 2 Assial CT scan showing the tumor (arrow). | yes |
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