title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Summary of adverse events (AEs) by safety analysis set. | diarrhoea, myalgia, fatigue, headache, arthralgia | ADVERSE EVENT | AE, adverse event.For AEs at the indicated severity with two numbers, n represents the number of participants per category/number of AEs as one participant experienced several cases of the same AE during the study.The most commonly reported reactions in the Ad5-nCoV group included increase in body temperature (20.2%), ... | PMC9994755 |
Injection site reactions | swelling, pain | INDURATION, INJECTION SITE REACTION, INJECTION SITE REACTIONS | Injection site reactions occurred in 106 participants (28.5%) who received the Ad5-nCoV vaccine. By comparison, only 2 participants in the Placebo group (1.6%) experienced an injection site reaction including swelling and pain or induration ( | PMC9994755 |
Other adverse events (excluding immunisation reactions) | SAEs | EVENTS, INJECTION SITE REACTION | As listed in For most participants, AEs were mild, reported in 28.5% of the Ad5-nCoV group and 16.1% of the Placebo group. Moderate events were registered in 5.6% of participants who received the Ad5-nCoV vaccine and 4.0% who received the placebo. By comparison, SAEs occurred in 0.8% of participants in the Ad5-nCoV gro... | PMC9994755 |
Discussion | RBD, headache, pain | ADVERSE REACTIONS, SECONDARY, ADENOVIRUS | In this multicentre, randomised, double-blind, placebo-controlled, phase 3 trial including 500 adult participants aged 18–85 years (mean age: 41.2 years), the immunogenicity, efficacy and safety of the Ad5-nCoV COVID-19 vaccine was assessed up to 6 months after vaccination. Both study groups (Ad5-nCoV and Placebo) had ... | PMC9994755 |
Conclusions | infections | VIRUS, INFECTIONS | Analysis of data from this phase 3 trial demonstrated the immunogenicity and safety of this Ad5-vector based COVID-19 vaccine. More data are required to determine whether this vaccine reduces infections and transmission. Overall, this stable, single-dose vaccine could contribute to the global fight against the evolving... | PMC9994755 |
Supporting information | PMC9994755 | |||
CONSORT checklist. | (DOC)Click here for additional data file. | PMC9994755 | ||
Study protocol. | (DOCX)Click here for additional data file. | PMC9994755 | ||
Additional details of statistical analysis. | (DOCX)Click here for additional data file. | PMC9994755 | ||
Summary of geometric mean titres and seroconversion rates post-vaccination with Ad5-nCoV or placebo (full analysis set). | (DOCX)Click here for additional data file. | PMC9994755 | ||
Systemic (general) post-vaccination reactions (safety analysis set). | (DOCX)Click here for additional data file. | PMC9994755 | ||
Systemic (general) post-vaccination reactions by severity (safety analysis set). | (DOCX)Click here for additional data file. | PMC9994755 | ||
Summary of all severe adverse events that led to hospitalisation or prolonged hospitalisation (safety analysis set). | (DOCX)Click here for additional data file. | PMC9994755 | ||
Local post-vaccination reactions (safety analysis set). | (DOCX)Click here for additional data file. | PMC9994755 | ||
Local post-vaccination reactions by severity (safety analysis set). | (DOCX)Click here for additional data file. | PMC9994755 | ||
Other adverse events unrelated to vaccination reactions (safety analysis set). | (DOCX)Click here for additional data file. | PMC9994755 | ||
Background | neck pain | The advancement of technology has contributed to a more sedentary lifestyle, and the extensive use of handheld devices among adolescents may potentially result in neck pain. This study aimed to assess the association between exposure to common technology devices and self-reported neck pain in Iranian school-age adolesc... | PMC10644474 | |
Methods | pain | This cross-sectional study was conducted between June and October 2021, employing a randomized multi-stage cluster sampling approach. We enrolled 808 adolescent students aged 11 to 19 years old. We asked participants about any neck pain they experienced in the week leading up to the study. Additionally, we gathered dem... | PMC10644474 | |
Results | neck pain | REGRESSION | Our study comprised 73.5% female participants with an average age of 15.1 ± 1.7 years and 26.5% male participants with an average age of 14.5 ± 1.5 years. In the regression model, the female gender (p = 0.038), using mobile for more than 6 h (p = 0.04), and using electronic devices while sitting on the floor (p = 0.02)... | PMC10644474 |
Conclusion | neck pain | In our study, we observed a relatively high prevalence of neck pain, which was linked to extended daily mobile phone usage and body posture during electronic device use. Policymakers may consider interventions aimed at reducing mobile phone usage and promoting proper body posture while using electronic devices as poten... | PMC10644474 | |
Keywords | PMC10644474 | |||
Background | neck pain, Musculoskeletal pain | Musculoskeletal pain (MSKP) is a global health concern that affects individuals of all ages and genders, presenting with diverse manifestations [Information and Communication Technology (ICT) comprises a wide range of devices, including mobile phones, tablets, gaming consoles, televisions, computers, and laptops. [Stud... | PMC10644474 | |
Method and materials | PMC10644474 | |||
Design | This cross-sectional study was conducted from June to October 2021. The ethics committee of Tehran University of Medical Sciences approved the study (ethics code: IR.TUMS.IKHC.REC.1400.320). The ethics committee waived the parental consent for this study as this was an observational study with no intervention. | PMC10644474 | ||
Participants & setting | We calculated the sample size using G*Power 3.1.9.7. Employing the Exact test family and a binomial statistical test, with a small effect size of 0.05, α = 0.05, and power = 0.8, we determined a sample size of 786 participants. To accommodate an anticipated dropout rate of 5%, we enrolled 808 individuals in our study [... | PMC10644474 | ||
Measurements | Our questionnaire evaluated three groups of variables, including basic and demographic variables, exposures, and outcomes.The demographic variables included age (years), gender (male or female), educational level (level one high school or level two high school), body mass index (BMI), and family structure (living with ... | PMC10644474 | ||
Statistical analysis | neck pain | REGRESSION | Mean and standard deviation (SD) were calculated for continuous variables. Number and percentage were calculated for categorical variables. We used the Fisher exact or Chi-square tests to compare the categorical variables across groups. We used a binary logistic regression model to determine the factors independently a... | PMC10644474 |
Results | neck pain | REGRESSION | Eight hundred-eight adolescents aged 11 to 19 were included in our study. Our sample included 73.5% female participants, with a mean age of 15.1 ± 1.7 years, and 26.5% male participants, with an average age of 14.5 ± 1.5 years. Among all participants, 95.2% lived with both parents, while 3.3% lived with their mother, 0... | PMC10644474 |
Discussion | neck pain, fatigue, pain | REGRESSION, MUSCULOSKELETAL DISORDERS | MSKPs often lack definitive treatments and may require prolonged therapeutic interventions, resulting in significant adverse consequences affecting healthcare demands, daily functional abilities, and adolescent social engagement [Among the devices we examined in our study, mobile phones emerged as the most commonly use... | PMC10644474 |
Limitations | neck pain | This study had a cross-sectional design, which is inappropriate for evaluating causal relationships between variables, and there is a need for future longitudinal studies to determine the risk factors of neck pain among Iranian adolescents. Furthermore, as this study was limited to Qazvin province, we may not generaliz... | PMC10644474 | |
Conclusion | neck pain | The prevalence of neck pain was relatively high in our study and was associated with using mobile phones for more than six hours a day and the body position while using electronic devices. Considering that mobile phones are widely used electronic devices among adolescents, they could be a possible target for future int... | PMC10644474 | |
Acknowledgements | N/A. | PMC10644474 | ||
Authors’ contributions | MA designed the study. SR and AY collected the data. MA supervised the study. AB analyzed the data. AH, MS, and ANA wrote the initial draft of the manuscript. All authors read and approved the final manuscript. | PMC10644474 | ||
Funding | This study was not funded. | PMC10644474 | ||
Data Availability | The datasets generated and/or analysed during the current study are not publicly available to keep the confidentiality of data and privacy of participants, but are available from the corresponding author on reasonable request. | PMC10644474 | ||
Declarations | PMC10644474 | |||
Ethics approval and consent to participate | We declare that all methods were performed in accordance with the relevant guidelines and regulations.The ethics committee of Tehran University of Medical Sciences approved the study (ethics code: IR.TUMS.IKHC.REC.1400.320). Also, participants provided informed consent prior to their participation in the study. | PMC10644474 | ||
Consent for publication | N/A. | PMC10644474 | ||
Competing interests | The authors declare no competing interests. | PMC10644474 | ||
References | PMC10644474 | |||
2. Materials and Methods | PMC10744600 | |||
2.1. Trial Design and Participants | dentine lesions, Caries, caries | DENTAL CARIES, SYSTEMIC DISEASE, CARIES, CARIES, MOTOR DISORDERS | This study was designed as a double-blind three-parallel-group randomized controlled trial, in which the subject, operator, and evaluator were masked to the group assignment. It was accepted by the Comisión de Ética, Facultad de Odontología, Universidad de Buenos Aires No. FOUBA 29/05/2013-52.A sample size calculation ... | PMC10744600 |
2.2. Intervention | calculus, Caries lesions, caries, primary dentition | CARIES | As described above, the children were randomly divided into three different groups according to the mode of treatment:NaF varnish group (NaFV) APF in tray group (APFt) APF in toothbrush group (APFtbru) Three-row children’s brushes with soft, rounded nylon bristles, a compact head and a straight handle were used for all... | PMC10744600 |
2.3. Dental Examination and Monitoring | caries lesions | Observations and clinical examinations were conducted at schools. After 12 and 24 months, the clinical examination was repeated to assess the dental status of schoolchildren following the same criteria described. The presence of new caries lesions was taken as a dependent variable. So, sound surfaces on baseline were o... | PMC10744600 | |
2.4. Statistical Analysis | caries’ | All the data were input into a spreadsheet (Microsoft Excel 2021 for Mac, version 16.4.8). A chi-square test was performed for CTNI changes between experimental groups and follow-up examinations; moreover, tests for trends across ordered experimental groups were tested using the Cuzick’s test trends.Cox Proportional Ha... | PMC10744600 | |
3. Results | caries lesions, caries | CARIES | Overall, 16,719 dental surfaces from 180 kids were included in this study. The CONSORT flow-chart is displayed in The calibration procedure was successfully performed. The level of agreement overall ranged from 90.44% for caries lesions at enamel level (ICDAS 2) to 94.50% for caries lesions at deep dentinal level (ICDA... | PMC10744600 |
4. Discussion | caries | DENTAL CARIES, CARIES | In this study, the use of an alternative application technique for the application of (APF) has been shown to be effective in maintaining healthy surfaces over 24 months.Different caries preventive program strategies were carried out in many countries to decrease caries prevalence and incidence [Fluoride varnishes stan... | PMC10744600 |
Author Contributions | Conceptualization, A.L.S., A.F.S. and G.K.; methodology and data collection, A.L.S., S.F. and R.L.; formal analysis, P.S. and G.C.; investigation, A.L.S., S.F., R.L. and A.F.S.; resources, A.F.S.; data curation, A.L.S.; writing—original draft preparation, A.L.S. and G.C.; writing—review and editing, A.F.S. and G.C.; su... | PMC10744600 | ||
Institutional Review Board Statement | The study protocol was approved by the Research Ethics Committee of the University of Buenos Aires, UBACYT 20020120100324BA (13 December 2016) and registered at | PMC10744600 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC10744600 | ||
Data Availability Statement | The data presented in this study are available on request from the corresponding author. | PMC10744600 | ||
Conflicts of Interest | The authors declare no conflict of interest. | PMC10744600 | ||
Background | mucocutaneous, OLP | ORAL LICHEN PLANUS, ADVERSE EFFECT | Oral lichen planus (OLP) is a chronic mucocutaneous immunologically mediated condition that has a great adverse effect on oral functions. Corticosteroids are still the first drugs of choice used in the treatment of OLP; however, they have extensive medical side effects. The present study was carried out to assess the c... | PMC10360223 |
Subjects and methods | pain | We performed a randomized, double blinded controlled trial at the Faculty of Dentistry, Cairo University, Egypt. The study was conducted on 34 patients suffering from symptomatic OLP. Patients were randomly divided into two groups: intervention group (I),who received topical CoQ10 in the form of mucoadhesive tablets (4... | PMC10360223 | |
Results | pain | Both groups showed a significant reduction in pain and the size of the lesions ( | PMC10360223 | |
Conclusions | The topical use of CoQ10 mucoadhesive tablets was as effective as the topical use of triamcinolone acetonide, and its clinical effect was associated with a reduction in the salivary level of MDA. | PMC10360223 | ||
Trial registration | The study protocol was registered at | PMC10360223 | ||
Keywords | Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). | PMC10360223 | ||
Introduction | immune-mediated disease of the oral mucosa, tumor necrosis, OLLs, TNF-α, GVHD, OLP | TUMOR NECROSIS, GRAFT VERSUS HOST DISEASE, ORAL LICHEN PLANUS, LYMPHOCYTIC INFILTRATION, GVHD | Oral lichen planus (OLP) is a relatively common chronic mucocutaneous inflammatory immune-mediated disease of the oral mucosa [On the other hand, oral lichenoid lesions (OLLs) are a term used to identify conditions that are clinically and histopathologically similar to OLP but with identifiable, either local or systemi... | PMC10360223 |
Subjects and methods | PMC10360223 | |||
Study design | The present study is a randomized controlled clinical trial (two parallel groups) with an allocation ratio of 1:1. The number of patients was equal in each group. The study was conducted following the principles of the Helsinki Declaration and was approved by the Research Ethics Committee of the Faculty of Dentistry, C... | PMC10360223 | ||
Study participants | The patients were recruited from the Diagnostic Center, as well as the Clinics of the Oral Medicine and Periodontology Department, at the Faculty of Dentistry, Cairo University, during the period from September 2019 to February 2022. According to specific inclusion and exclusion criteria | PMC10360223 | ||
Inclusion criteria | OLP | SYSTEMIC DISEASE |
Patients were more than 18 years old.Patients were free from any systemic disease according to the detailed questionnaire of the modified Cornell Medical Index [Patients clinically diagnosed by a dermatologist and oral medicine specialist as suffering from OLP.Patients who agreed to the biopsy in undiagnosed casesClin... | PMC10360223 |
Exclusion criteria | LICHENOID REACTION |
Patients taking systemic drugs such as systemic steroids, or other immunosuppressive therapies for at least 8 weeks prior to the study.Patients treated with any oral topical medications for at least four weeks prior to the study.Patients receiving any medication either topical or systemic that could cause lichenoid re... | PMC10360223 | |
Study interventions | The present study was conducted on 34 patients suffering from symptomatic OLP. Patients were randomly divided into two groups and received both treatments in the form of opaque sealed jars (Jar A) for adhesive tablets (Fig. Opaque sealed jar containing mucoadhesive CoQ10 tablets | PMC10360223 | ||
Group I (intervention group) | Seventeen participants received topical coenzyme Q10 (ubiquinol) in the form of mucoadhesive tablets, (Fig. | PMC10360223 | ||
CoQ10 mucoadhesive tablet preparation | The tablets were prepared using 120 mg coQ10 powder (in reduced form which is the antioxidant form) [Mucoadhesive CoQ10 tablets | PMC10360223 | ||
Group II (control group) | Seventeen participants received topical corticosteroid (kenacorte in Orabase: triamcinolone acetonide 0.1% 5-g adhesive paste – dermapharm), (Fig. Opaque sealed jar containing triamcinolone acetonide paste | PMC10360223 | ||
Study outcomes | erosion, Pain, pain | CAVITY, EROSION, ATROPHIC |
Primary outcome1.1. Pain measurement using the Visual Analogue Scale: according to Maxwell [All patients were asked to define their level of pain and discomfort by using a numerical rating from 0 to 10 (11-points), with 0 indicating "no pain", 1 to 3 indicating mild pain, 4 to 6 indicating moderate pain, 7 to 9 indica... | PMC10360223 |
Saliva sample collection | Whole unstimulated saliva (WUS) was collected between 8 am to 1 pm using standard techniques according to Navazesh [ | PMC10360223 | ||
Determination of human malondialdehyde (MDA) in saliva using an ELISA kit (prepared by Prof. OS) | Saliva samples were centrifuged for 10 min at 4000 xg. The supernatant was separated and used for determination of MDA levels using ELISA Kit Cat No. MBS263626 provided by My BioSource (USA, NY). This kit employs the “Double Antibody Sandwich” technique. The principle of double antibody sandwich is based on the charact... | PMC10360223 | ||
Sample size calculation | Thomas | An interventional study by Thomas et al. [ | PMC10360223 | |
Randomization and allocation concealment | Simple randomization was generated using | PMC10360223 | ||
Masking/blinding | Neither the statistician nor clinical outcome assessor (associate prof. AH) were aware of which medication was being administered, thus yielding a double-blind controlled study. | PMC10360223 | ||
Data collection and statistical analysis | All data collected from patients using clinical parameters were recorded electronically for statistical analysis. Categorical data are presented as frequencies (n), and percentages (%), and the chi square test was used for the analysis. Quantitative data were explored for normality using Kolmogorov–Smirnov and Shapiro–... | PMC10360223 | ||
Results | thirty-four, OLP | ADVERSE EFFECTS, SYSTEMIC DISEASE, RECRUITMENT | During the recruitment phase, 36 patients were assessed for eligibility from September 2019 to February 2022. Two patients did not meet the inclusion criteria due to their chronic systemic diseases. Only thirty-four participants were eligible for inclusion. All patients gave written informed consent and were randomly a... | PMC10360223 |
Discussion | pain, OLP | ADHESION, ADVERSE DRUG EFFECTS, OXIDATIVE STRESS | The chronic nature of OLP, prolonged course of treatment, and frequent exacerbation of the condition increase the incidence of steroid side effects [In addition to the antioxidant and anti-inflammatory effects of CoQ10, its topical use in the form of mucoadhesive tablets in the present study has many advantages includi... | PMC10360223 |
Conclusions | pain | OXIDATIVE STRESS |
Topical application of mucoadhesive CoQ10 tablets on symptomatic OLP lesions leads to significant pain relief and clinical improvement of the condition in addition to decreasing the salivary levels of one of the markers of oxidative stress (MDA).CoQ10 in a mucoadhesive formula is as effective as the standard treatment... | PMC10360223 |
Recommendations | OLP | REMISSION |
Studies with larger sample sizes are needed to conclude the effective role of CoQ10 in the management of symptomatic OLP.Different concentrations of CoQ10 need to be used to reach the optimum dose required to achieve optimum management of OLP with no side effects.The period between lesion remission and exacerbation fo... | PMC10360223 |
Acknowledgements | The authors of the study would like to express the greatest thanks to all the staff members of the Oral Medicine Department, Faculty of Dentistry, and Cairo University for their cooperation, kind feelings and for sparing no effort in helping us, as well as many thanks to Mepaco_Arab Co. For Pharmaceuticals and Medicine... | PMC10360223 | ||
Authors’ contributions | A.H. | M.A. responsible for the funding and undergoing the clinical and theoretical work of the trial, collecting data, clarification, conclusions and drafting the manuscript. F.Z. responsible for patients’ randomization, providing guidance through the clinical work, revising the theoretical part and help with the conclusions... | PMC10360223 | |
Funding | Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). Self-funded. | PMC10360223 | ||
Availability of data and materials | The datasets used and/or analyzed during the current study are not publicly available due [for better patient data confidentiality] but are available from the corresponding author on reasonable request. | PMC10360223 | ||
Declarations | PMC10360223 | |||
Ethics approval and consent to participate | The study was conducted following the principles of the Helsinki Declaration and was approved by the Research Ethics Committee of the Faculty of Dentistry, Cairo University (code: 19923). All patients were informed about the nature and objectives of the study. All participants read, approved, and signed a written infor... | PMC10360223 | ||
Consent for publication | Not applicable. | PMC10360223 | ||
Competing interests | The authors declare no competing interests. | PMC10360223 | ||
References | PMC10360223 | |||
Background | Social media has emerged as an effective tool to mitigate preventable and costly health issues with social network interventions (SNIs), but a precision public health approach is still lacking to improve health equity and account for population disparities. | PMC10267788 | ||
Objective | This study aimed to (1) develop an SNI framework for precision public health using control systems engineering to improve the delivery of digital educational interventions for health behavior change and (2) validate the SNI framework to increase organ donation awareness in California, taking into account underlying pop... | PMC10267788 | ||
Methods | PID | This study developed and tested an SNI framework that uses publicly available data at the ZIP Code Tabulation Area (ZCTA) level to uncover demographic environments using clustering analysis, which is then used to guide digital health interventions using the Meta business platform. The SNI delivered 5 tailored organ don... | PMC10267788 | |
Results | Four main clusters with distinctive sociodemographic characteristics were identified for the state of California. The ACT mechanism significantly increased the overall click rate per 1000 impressions (β=.2187; | PMC10267788 | ||
Conclusions | The proposed SNI framework, with its ACT mechanism, learns and delivers, in real time, for each distinct subpopulation, the most tailored educational content and establishes a new standard for precision public health to design novel health interventions with the use of social media, automation, and machine learning in ... | PMC10267788 | ||
Trial Registration | ClinicalTrials.gov NTC04850287; https://clinicaltrials.gov/ct2/show/NCT04850287 | PMC10267788 | ||
Introduction | PID | Health care expenditures, especially in the United States, continue to rise [Social network interventions (SNIs) enable the development of large-scale and tailored educational interventions but also need to account for population disparities. SNIs have been increasingly adopted for health behavior change [The design of... | PMC10267788 | |
Methods | PMC10267788 | |||
Overview | The SNI framework is a precision digital education approach developed to enable, test, and improve large-scale and equitable access to health literacy by automating four components: (1) population stratification into demographic environments, (2) cluster-randomized assignment, (3) personalized digital content delivery,... | PMC10267788 | ||
Study Design, Study Setting, and Participants | This was a 3-month, prospective, cluster randomized trial (CRT) to evaluate the engagement performance of optimal and nonoptimal SNIs on health educational content delivered as ads using Meta’s Business Platform (Facebook) [The study setting was the Meta Business Platform [ | PMC10267788 | ||
Study Outcome | The main study outcome was the number of link clicks per 1000 impressions (C/I) on the health educational content, which is a measure of social media engagement retrieved from Facebook and used as a surrogate marker of awareness [ | PMC10267788 | ||
Study Variables | The study variables were the use of ACT mechanism optimization (optimal and nonoptimal) and the type of demographic environment (4 uncovered clusters). The ACT mechanism was applied to the optimal group, and the demographic environments are defined at the ZCTA level. | PMC10267788 |
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