title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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2.2. Diet, Physical Activity and Weight Data Collection | Both the postnatal diet and PA data collection and coding replicated the methods used during the pregnancy phase of the study, which have been published [PA data were collected using the 32-item validated Pregnancy PA Questionnaire (PPAQ), including questions about the type and duration of activity in the previous week... | PMC10490453 | ||
2.3. Data Analysis | obesity | OBESITY | Not all participants completed each follow-up questionnaire. Therefore, cross-sectional analysis was undertaken at each postnatal time point. As these are pilot data, descriptive analysis was carried out on women’s diet, PA, and weight change data at 3-, 6-, 9- and 12-months postnatal to explore patterns. Comparison of... | PMC10490453 |
3. Results | PMC10490453 | |||
3.1. Participants Characteristics | In total, 39 women who returned pregnancy questionnaires also returned postnatal questionnaires at one or more time points (38%) between March 2018 and June 2019. At 3-, 6-, 9- and 12-months postnatal, the socio-demographic, diet and PA data were available for 24 (23.1%), 22 (21.2%), 12 (11.5%) and 20 (19.2%) women, re... | PMC10490453 | ||
3.2. Dietary Behaviours | Across the postnatal time points, the median milk intake was 142 mL/day, spread ranged from 5–10 g/day, and cheese 4–12 g/day ( | PMC10490453 | ||
3.3. Physical Activity Behaviours | Reported levels of PA showed a pattern towards higher median EE with each postnatal time point, from 213.4 MET-hr/week at 3-months postnatal to 300.7 MET-h/week at 12-months ( | PMC10490453 | ||
3.4. Postnatal Weight Change | 3rd-trimester, weight loss | All women in this study had their weight recorded at their booking appointment, and at least one postnatal weight was available for 35 women. The last recorded postnatal weight for 21 women (60%) was lower than their booking weight. When looking at weight change, the median values across all time points showed weight l... | PMC10490453 | |
4. Discussion | obesity, 3rd-trimester, weight loss | OBESITY, SECONDARY | This secondary analysis has provided novel data on postnatal diet, PA, and weight change among a highly deprived population of women living with obesity in the UK. This population had a suboptimal dietary intake, particularly regarding fruit and vegetables, unrefined breakfast cereals, fish, and oily fish, which did no... | PMC10490453 |
Strengths and Limitations | obesity | OBESITY, SECONDARY | This is one of the first studies to explore the postnatal dietary and PA behaviours of women living with obesity in an area of high deprivation in the UK. Extensive data were collected as part of the GLOWING pilot trial, providing a rich dataset for analysis. However, this study was a secondary data analysis with a sma... | PMC10490453 |
5. Conclusions | obesity, weight loss | OBESITY | The postnatal period is important for the mother’s long-term health, as well as preconception health for those who have subsequent pregnancies. This descriptive study suggests that, among a highly deprived population of women living with obesity in the UK, postnatal diet and PA behaviours are inadequate and do not meet... | PMC10490453 |
Supplementary Materials | The following supporting information can be downloaded at: Click here for additional data file. | PMC10490453 | ||
Author Contributions | N.H. | Conceptualization, N.H., E.M., J.R., F.F.S. and C.M.; methodology, N.H., E.M., J.R., A.C.F., L.S., C.B., E.C. and F.F.S.; validation, N.H., E.C., L.S., C.B. and C.M.; formal analysis, N.H., E.C., C.M., C.B., L.S. and A.C.F.; investigation, N.H. and C.M.; data curation, N.H., C.M., E.M., J.R. and F.F.S.; writing—origina... | PMC10490453 | |
Institutional Review Board Statement | This study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Proportionate Review Sub-committee of the Yorkshire and The Humber—South Yorkshire Research Ethics Committee (ref: 15/YH/0565, 16 December 2015). | PMC10490453 | ||
Informed Consent Statement | Informed written consent was obtained from all participants involved in this study. | PMC10490453 | ||
Data Availability Statement | The data presented in this study are available on request from the corresponding author. The data are not publicly available due to ethical approval restrictions, and any further data sharing will be subject to necessary approvals. | PMC10490453 | ||
Conflicts of Interest | The authors declare no conflict of interest. The funders had no role in the study’s design, in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results. | PMC10490453 | ||
Background | PERIODONTITIS, INFLAMMATORY DISORDER | During the last decades, in patients with periodontitis, periodontal treatment has been shown to reduce the potential release of local and systemic biomarkers linked to an early risk of systemic inflammatory disorders. This study evaluated the efficacy of non-surgical-periodontal treatment (NSPT) on growth differentiat... | PMC10440880 | |
Methods | periodontitis | PERIODONTITIS | For this two-arm, parallel randomized clinical trial, patients with periodontitis were randomly allocated to receive quadrant scaling and root-planing (Q-SRP, n = 23, median age 51 years old) or full-mouth disinfection (FMD, n = 23, median age 50 years old) treatment. Clinical and periodontal parameters were recorded i... | PMC10440880 |
Results | In comparison with FMD, patients of the Q-SRP group showed a significant improvement in clinical periodontal parameters (p < 0.05) and a reduction in the mean levels of GDF-15 (p = 0.005), hs-CRP (p < 0.001), and SP-D (p = 0.042) and an increase of GPx-1 (p = 0.025) concentrations after 6 months of treatment. At 6 mont... | PMC10440880 | ||
Conclusion | The results evidenced that, after 6 months of treatment, both NSPT protocols improved the periodontal parameters and analyzed biomarkers, but Q-SRP was more efficacious than the FMD approach. Moreover, patients who presented high baseline GDF-15 and SP-D levels benefited more from NSPT at 6-month follow-up. | PMC10440880 | ||
Trial registration | NCT05720481. | PMC10440880 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12903-023-03237-y. | PMC10440880 | ||
Keywords | PMC10440880 | |||
Introduction | periodontitis, CVD, tooth loss, Periodontitis, heart failure | ENDOTHELIAL DYSFUNCTION, CVD, PERIODONTITIS, PERIODONTITIS, HEART FAILURE, INFLAMMATORY DISEASE, INFLAMMATORY RESPONSE | Periodontitis is a chronic, multifactorial, inflammatory disease caused by infectious biofilm that, if not prevented and treated appropriately, might destroy the tooth-supporting tissues and cause tooth loss [Recently some cohort clinical trials have shown that the growth differentiation factor 15 (GDF-15), a biomarker... | PMC10440880 |
Materials and methods | PMC10440880 | |||
Study design and sample | periodontitis, bleeding, PD, tooth | PERIODONTITIS, BLEEDING, ALVEOLAR BONE LOSS, PLAQUE | The present RCT was performed according to the 2016 Helsinki Declaration on medical research. The ethical approval was obtained from the International Review Board of the University of Catania, Catania, Italy (22–149 PO). All participants signed the research informed consent; the study was retrospectively registered on... | PMC10440880 |
Sample size and reliability analysis | The power sample analysis, calculated using statistical software (G* POWER, Universität Düsseldorf, Germany), was obtained by setting up serum GDF-15 as a primary outcome variable [An inter-examiner reliability test among examiners (S.S., A.L.G.) was performed using Cohen’s kappa coefficient and showed an agreement of ... | PMC10440880 | ||
Randomization | Through a permuted block design, the randomization was performed by a single clinician, not involved in the subsequent trial stages, which generated a random assignment of a treatment using a sequence 1:1 ratio by a computer random-number generator.Each patient was allocated to receive Q-SRP or FMD. The allocation was ... | PMC10440880 | ||
Study outcomes | SECONDARY | The primary outcome was the analysis of serum GDF-15 expression changes between groups after 6 months following NSPT protocols. Furthermore, the impact of NSPT on GPx-1, hs-CRP, and SP-D concentration changes was analysed after 6 months of treatment. The secondary objective was to examine the influence and interaction ... | PMC10440880 | |
Treatment | Shortly after the baseline assessments, each enrolled patient received oral hygiene instructions. Patients allocated to the FMD group received a full mouth SRP in one side of the mouth for each session, within 24 h in two separate sessions, on two consecutive days with the adjunctive use of local antiseptic in accordan... | PMC10440880 | ||
Sampling | At baseline and at 3- and 6 months after NSPT, blood samples from each patient were taken between 8:00 and 10:00 a.m., before any periodontal examination. Following sampling, serum samples were centrifuged at 4 °C (1000x g for 2 min) and stored. The serum GDF-15, GPx-1, and SP-D concentration levels were obtained using... | PMC10440880 | ||
Statistical analysis | SECONDARY | Numerical data were expressed by mean ± standard deviation (SD), while categorical variables were reported as numbers and percentages. Because most of the analyzed variables were not normally distributed, as verified by the Kolmogorov-Smirnov test, a non-parametric approach was applied. The Mann-Whitney test was used f... | PMC10440880 | |
Results | PMC10440880 | |||
Primary outcome | Bleeding, PD | BLEEDING, PLAQUE | In comparison with the FMD group, at 6 months after therapy, the Q-SRP group showed a significant reduction of the GDF-15 levels (p = 0.012) (Table
Differences among GDF-15, GPx-1, hs-CRP and SP-D at baseline and at each follow-up session. Results are expressed as mean and SD (standard deviation). a, significance betw... | PMC10440880 |
Secondary outcome | INTERACTION | The estimation of models aimed to determine the impact of Q-SRP and timing of treatment on GDF-15, GPx-1, hs-CRP, and SP-D concentration changes at 6 months using a two-way ANOVA test revealed that Q-SRP had a significant effect on the reduction of serum GDF-15 (p = 0.015), GPx-1 (p = 0.045), and SP-D (p = 0.045) toget... | PMC10440880 | |
Discussion | periodontitis, infection, CVD | SYSTEMIC DISEASE, CVD, PERIODONTITIS, CHRONIC INFLAMMATORY DISEASE, INFECTION, PERIODONTAL INFLAMMATION, INFLAMMATORY RESPONSE | In the last decade, an increasing amount of evidence has found that the chronic inflammatory stimulus linked to its pathogenic biofilm load is the real factor that directly connects periodontitis to many systemic diseases. Due to these factors, periodontal treatment, through its various approaches, has been shown to be... | PMC10440880 |
Acknowledgements | The authors acknowledge the staff of the Unit of Periodontology, School of Dentistry, of the University of Catania for their support. | PMC10440880 | ||
Authors’ contributions | G.I. conceived the research, planned and performed the experimental procedures and wrote the manuscript. G.M.T., A.L.G. and S.S. performed the procedures. A.C. and A.M. validated the experimental results and revised the manuscript. All authors reviewed the manuscript. | PMC10440880 | ||
Funding | The present research was funded by funds of the University of Catania, Italy, Grant | PMC10440880 | ||
Data Availability | Data are available from corresponding authors upon reasonable request. | PMC10440880 | ||
Declarations | PMC10440880 | |||
Ethics approval and consent to participate | International Review Board of the University of Catania approved the study protocol (22–149 PO). All patients signed an appropriate written informed consent for the study participation. The present RCT was performed according to CONSORT criteria and the 2016 Helsinki Declaration on medical research. | PMC10440880 | ||
Consent for publication | Not Applicable. | PMC10440880 | ||
Competing interests | The authors declare that they have no conflict or competing interests in the present study. | PMC10440880 | ||
References | PMC10440880 | |||
1. Introduction | T1DM, fatigue, LCD, Diabetes, diabetes | DIABETIC KETOACIDOSIS, TYPE 1 DIABETES MELLITUS, TYPE 1 DIABETES MELLITUS, HYPOGLYCEMIA, GLYCOGEN DEPLETION, GROWTH DELAY, DYSLIPIDEMIA, DIABETES, DIABETES | Objective: The aim of this study was to evaluate the macronutrient and micronutrient intake and status in youth with type 1 diabetes mellitus (T1DM) following the consumption of a low-carbohydrate diet (LCD). Research Methods and Procedures: In a prospective intervention clinical trial, adolescents with T1DM using a co... | PMC10051868 |
2. Materials and Methods | PMC10051868 | |||
2.1. Participants and Study Design | T1DM, Diabetes | DIABETES | This report documents a prospective intervention clinical trial conducted in the Pediatric Endocrinology and Diabetes Unit at the Sheba Medical Center. Eligibility criteria were a diagnosis of T1DM according to the American Diabetes Association criteria [ | PMC10051868 |
2.2. Diet Intervention | At baseline, each participant underwent a cooking workshop and received a personalized diet regime based on the LCD. For participants younger than 18 years, nutrition education was provided to both the participants and their parents. Participants met individually with a dietitian for diet instructions and support at we... | PMC10051868 | ||
2.3. Low-Carbohydrate Diet | The LCD aimed to provide 50–80 g/day of carbohydrates. There was no caloric restriction, but each patient received a weekly plan with main meals and snacks. The planned macronutrient composition of the diet (percentage of total calories) was: 20% carbohydrate, 25% protein, and 55% fat. All the dietary details were stat... | PMC10051868 | ||
2.4. Assessment of Nutritional Composition | The habitual food consumption of the participants was evaluated using the Food Frequency Questionnaire (FFQ), which was taken at baseline and after six months of intervention. The FFQ included 116 food items commonly eaten in Israel, standard portion sizes, and a frequency response section. It is based on a validated F... | PMC10051868 | ||
2.5. Medical History and Anthropometric Measurements | diabetes | DIABETES | Age of diabetes onset, diabetes duration, and other medical diagnoses data were retrieved from medical records. Height, weight, and waist circumference were measured at each visit according to standardized protocol by trained and certified staff. Body mass index (BMI) was calculated as weight (kg)/height squared (m | PMC10051868 |
2.6. Biochemical Parameters | diabetic ketoacidosis | DIABETIC KETOACIDOSIS, BLOOD | Blood samples including HbA1c, total cholesterol, LDL cholesterol, and HDL cholesterol were collected under metabolic stability conditions. The latter were defined as no episode of diabetic ketoacidosis within 1 month before the visit and after ≥12 h of fasting. Laboratory results of serum C-reactive protein (CRP), blo... | PMC10051868 |
2.7. Trial Outcomes | Our primary endpoint was nutritional vitamins and mineral status after 24 weeks of an LCD. Secondary outcomes were body weight and waist circumference at this time point. | PMC10051868 | ||
2.8. Statistical Analysis | Categorical variables were described using frequencies and percentages. Continuous variables were expressed as medians and interquartile ranges (IQR, 25th; 75th percentiles). The Wilcoxon test was used to compare continuous variables before and after the 6-month period. Spearman’s correlation coefficient test was used ... | PMC10051868 | ||
3. Results | PMC10051868 | |||
3.1. Study Group Characteristics | obesity, T1DM, diabetes | OBESITY, DIABETES | Twenty adolescents with T1DM (14 females) were enrolled in the study at median (IQR) age of 17 years (15; 19). The median diabetes duration was 10 years (8; 12). Eighteen participants were treated with an insulin pump and two were treated with multiple daily injections. The median BMI z-score was 1.3 (0.65; 1.50); nine... | PMC10051868 |
3.2. FQQ | The median baseline percent from calories of carbohydrates was 44% (37; 47); from protein, 18% (16.5; 20); and from fat, 35% (30; 37). Baseline median percentages of micronutrients were calculated according to DRI values as follows: fiber 115% (97.5; 145.5), iron 101% (85; 138), magnesium 145% (118; 180), calcium 116% ... | PMC10051868 | ||
3.3. Weight Loss and Waist Circumference | The LCD was associated with significant reductions in median BMI z-scores ( | PMC10051868 | ||
3.4. Blood Laboratory Measurements | The median (interquartile range) HbA1c level declined after LCD, from 8.1% (7.5; 9.4) to 7.7% (6.9; 8.2), | PMC10051868 | ||
3.5. Correlations | Delta body weight was not correlated with any of the parameters examined. The delta of calories from ultra-processed food did not correlate with any of the macronutrients or micronutrients examined. | PMC10051868 | ||
4. Discussion | T1DM, TIDM, LCD, metabolic syndrome, Nutritional deficiencies, diabetes | TRACE ELEMENT DEFICIENCY, AIDS, EVENTS, MAGNESIUM DEFICIENCY, NUTRITIONAL DEFICIENCIES, METABOLIC SYNDROME, DIABETES | In this novel study of youth with TIDM who followed LCD for six months, decreases were found in median intakes of several macronutrients and micronutrients. Median blood levels of several nutrients decreased. These changes were in parallel to an improved median HbA1c level and lower median values of CRP, BMI z-score, a... | PMC10051868 |
5. Conclusions | diabetes | DIABETES | Medical nutrition therapy remains a cornerstone of diabetes care [ | PMC10051868 |
Supplementary Materials | The following supporting information can be downloaded at: Click here for additional data file. | PMC10051868 | ||
Author Contributions | Neriya | Conceptualization, N.L. (Neriya Levran), A.A., E.M.-O. and O.P.-H.; Data curation, N.L. (Neriya Levran); Formal analysis, N.L. (Neriya Levran) and O.P.-H.; Investigation, N.L. (Neriya Levran), N.L. (Noah Levek) and B.S.; Methodology, O.P.-H.; Project administration, O.P.-H.; Supervision, E.M.-O. and O.P.-H.; Writing—or... | PMC10051868 | |
Institutional Review Board Statement | The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethical Committee of Sheba Medical Centre (protocol number SMC-5537-18). Informed consent was obtained from obtained from all subjects involved in the study. | PMC10051868 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC10051868 | ||
Data Availability Statement | The data and the questioners are all in Hebrew and could be sent by a personal request. | PMC10051868 | ||
Conflicts of Interest | The authors declare no conflict of interest related to this work. | PMC10051868 | ||
Background | Since its beginnings in 2019, the COVID-19 pandemic is still a problem of global medical concern. Southern Vietnam is one of the country's vast regions, including 20 provinces and the densely populated metropolis Ho Chi Minh City. A randomized retrospective study was performed to investigate the epidemiology and geneti... | PMC10655423 | ||
Methods | Epidemiological data were obtained from the Department of Preventive Medicine of the Vietnamese Ministry of Health. To identify circulating variants, RNA, extracted from 126 nasopharyngeal swabs of patients with suspected COVID-19 were sequenced on Illunina MiSeq to obtain near complete genomes SARS-CoV-2. | PMC10655423 | ||
Results | Due to the effectiveness of restrictive measures in Vietnam, it was possible to keep incidence at a low level. The partial relaxation of restrictive measures, and the spread of Delta lineages, contributed to the beginning of a logarithmic increase in incidence. Lineages 20A-H circulated in Southern Vietnam during 2020.... | PMC10655423 | ||
Conclusions | Pandemic dynamics in Southern Vietnam feature specific variations in incidence, and these reflect the success of the restrictive measures put in place during the early stages of the pandemic. | PMC10655423 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12879-023-08814-8. | PMC10655423 | ||
Keywords | PMC10655423 | |||
Introduction | pneumonia | VIRUS, PNEUMONIA | In late December 2019, a group of patients with pneumonia of unknown etiology was reported in Wuhan, Hubei province, China [After applying many COVID-19 control measures (shutting down Wuhan on the 23rd of January, blocking all travel to and from the city), the daily number of cases in China subsequently decreased. In ... | PMC10655423 |
Materials and methods | PMC10655423 | |||
Epidemiological data and study materials | All epidemiological data were obtained periodically from the Department of Preventive Medicine, Vietnamese Ministry of Health [ | PMC10655423 | ||
RNA purification, Real-time PCR | Total RNA from nasopharyngeal swabs samples were obtained by extraction and purification using the QIAamp Viral RNA Extraction Kit (QIAGEN, Germany) with the QIAcube Connect automatic station (QIAGEN, Germany) according to the manufacturers recommendations. Samples were eluted and stored at -70° C until further analysi... | PMC10655423 | ||
SARS-CoV-2 genome enrichment | -20 | To create NGS libraries, viral RNA was subjected to reverse transcription and subsequent PCR enrichment. Reverse transcription was performed using random hexamers with the Reverta L Kit (AmpliSens, Russia) following the manufacturer's protocol. Samples (cDNA) were stored at -20°C until amplification. To obtain a near c... | PMC10655423 | |
Library preparation and sequencing | Library preparation was performed using the TruSeq DNA CD Indexes Kit (Illumina Inc., USA) according to the Illumina TruSeq Nano DNA Kit protocol. Sequencing was performed on a MiSeq instrument using MiSeq V3 chemistry, generating 2 × 200 bp reads. | PMC10655423 | ||
Genome assembly | The quality of the Illumina reads was assessed using the FastQC program [ | PMC10655423 | ||
Availability of data | Sequences were uploaded to GISAID under the following IDs for year 2020: EPI_ISL_812922, EPI_ISL_760247, EPI_ISL_17454567, EPI_ISL_17436319, EPI_ISL_17454569, EPI_ISL_654872-EPI_ISL_654874, EPI_ISL_17433648-EPI_ISL_17433661, EPI_ISL_654866-EPI_ISL_654870, EPI_ISL_654886-EPI_ISL_654889, and EPI_ISL_654875-EPI_ISL_654884... | PMC10655423 | ||
Variant annotation and phylogenetic tree reconstruction | Variant calling files (.vcf) were processed for the effect of SNP variation with the SnpEff tool ( | PMC10655423 | ||
Results | PMC10655423 | |||
Epidemiology of SARS-CoV-2 in Southern Vietnam, 2020–2021 | MAY, VIRUS | The first COVID-19 cases were confirmed in Southern Vietnam on January 23, 2020, when two Chinese individuals arrived in Ho Chi Minh City and tested positive for the virus [COVID-19 incidence rate in Southern Vietnamese regions in 2020. Due to restrictions on movement and border crossing under strict quarantine, the in... | PMC10655423 | |
Mutations in the SARS-CoV-2 spike protein gene in samples from Vietnam | MINOR | Of 126 genomes that underwent sequencing, 55 S gene sequence variants (SGSV) were identified based on SNP pattern. SGSV-1 was identical to the Wuhan-Hu-1/2019 (MN908947) reference strain without any SNPs or indels. The remaining 54 SGSVs had at least one SNP compared to the reference (Figs. Four different SGSVs were i... | PMC10655423 | |
Discussion | sudden increase | EVENTS, EVENT, SAID | COVID-19 continues to be a pressing public health problem. Different countries have had varying levels of success in combating the COVID-19 pandemic, with some countries among the most successful in the world at containing the pandemic and others in serious jeopardy. In the East Asia and Pacific regions, the most succe... | PMC10655423 |
Conclusion | Pandemic dynamics in Southern Vietnam feature specific variations in incidence, and these largely reflect the success of the substantial, ongoing restrictive measures put in place during the early stages of the pandemic. Tracking of circulating lineages revealed major variants from the list of variants-of-concern, incl... | PMC10655423 | ||
Acknowledgements | The authors would like to thank: Pham Thi Thu Hang, Vu Pham Hong Nhung, Nguyen Viet Thinh and Luong Chan Quang for their technical and epidemiological data assistance; and the US CDC for reagent support. | PMC10655423 | ||
Authors’ contributions | Conceptualization: ASG, TMC, VGD; investigation and methodology: ASG, TMC, EOK, MHD, AAS, VDM, MRP, TVA, VAS, NAT; formal analysis: ASG, TMC, EOK, MHD, AAS, VDM; resources: TMC, VGD; supervision: TMC, VGD; writing – original draft, ASG, TMC, EOK; writing – review & editing, ER. All authors have read and agreed to the f... | PMC10655423 | ||
Funding | The study was funded within the framework of Russian-Vietnamese cooperation in accordance with the Decree of the Government of the Russian Federation of July 13, 2019 (No. 1536-r). | PMC10655423 | ||
Availability of data and materials | Genomic consensus sequences obtained in this study are deposited in GISAID ( | PMC10655423 | ||
Declarations | PMC10655423 | |||
Ethics approval and consent to participate | The study was evaluated and approved by the local Ethics Committee of the St. Petersburg Pasteur Institute (St. Petersburg, Russia, № 063–03) and the Ethics Committee of the Pasteur Institute in Ho Chi Minh City (17/CN-HDDD). Research was performed according to the principles of Declaration of Helsinki for medical rese... | PMC10655423 | ||
Consent for publication | Not applicable. | PMC10655423 | ||
Competing interests | The authors declare no competing interests. | PMC10655423 | ||
References | PMC10655423 | |||
Background | fistula, gastro-cutaneous fistulae | COMPLICATION | Gastro-cutaneous fistula is a rare complication after laparoscopic sleeve gastrectomy (LSG) with incidence of occurrence 1–2%. Most of gastro-cutaneous fistulae do not respond to conservative management and need intervention either surgically or endoscopically.
| PMC10017559 |
Methods | fistula, post-LSG leak or gastro-cutaneous fistula | SECONDARY, RECURRENCE | This prospective randomized clinical study included referred patients who had LSG performed at our department or other centers, and complicated with post-LSG leak or gastro-cutaneous fistula between December/2019 and March/2021. Included patients were ASA Physical status I–II. Primary and secondary outcomes were recurr... | PMC10017559 |
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