title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Freedom from reintervention and aortic events | Freedom from valve, ascending aorta and arch reintervention at 5 years was similar with 98% for PEARS vs 94.6% for VSRR (p=0.1) (Kaplan-Meier estimate of freedom from aortic valve (AV) and ascending aorta/arch reintervention for total (A) and matched (B) cohorts, including 95% CIs. Graphs were truncated when less than ... | PMC10313978 | ||
Aortic regurgitation | AORTIC REGURGITATION | At last follow-up after PEARS (median 21 months, IQR 4–42), nearly 90% of patients had no AR and only one patient had an Both preoperatively and at discharge, patients undergoing VSRR were significantly more likely to have mild (1/4) AR. After PS matching, there was no significant difference in AR grade at these time p... | PMC10313978 | |
Discussion | death, stiff interposition, bleeding, external annuloplasty, deaths | DISEASE PROGRESSION, BLEEDING, AORTIC DISSECTION, EVENT, DISEASE, EVENTS, COMPLICATIONS | While the perioperative outcomes of PEARS and root replacement have been compared,Our study cohort was derived from real-world clinical data and consists of a selected population of young patients with predominantly MFS, normal ejection fraction and at most mild AR undergoing elective surgery. The PEARS 200 Database re... | PMC10313978 |
Data availability statement | Data are available upon reasonable request. | PMC10313978 | ||
Ethics statements | PMC10313978 | |||
Patient consent for publication | Not required. | PMC10313978 | ||
Ethics approval | For this retrospective study, the need for additional patient consent was waived (Ethical Committee of the University Hospitals Leuven, S63787). | PMC10313978 | ||
References | PMC10313978 | |||
Background | Healthy aging for all in the community is a shared public health agenda for countries with aging populations, but there is a lack of empirical evidence on community-wide preventive models that promote the health of older people residing in socially-disadvantaged communities. The Health and Wellness Program for Seniors ... | PMC9813466 | ||
Methods/design | HWePS is a prospective, non-randomized comparison trial conducted in an intervention and a control neighborhood ( | PMC9813466 | ||
Discussion | As a multi-level health equity project, HWePS has adopted a novel study design that simultaneously targets individual- and community-level factors known to contribute to health inequality in later life in the community. The study will provide insights into the effectiveness and implementation process of an integrated, ... | PMC9813466 | ||
Trial registration | ISRCTN29103760. Registered 2 September 2021, | PMC9813466 | ||
Keywords | PMC9813466 | |||
Background | Healthy aging is a widely accepted common goal of most countries with aging populations, regardless of income level. The proportion of older adults in the world’s population is expected to reach 16% by 2050 [Health equity is a critical goal of public health policy and practice. Beyond mere surveillance and monitoring o... | PMC9813466 | ||
Theoretical rationale | HL | The Health and Wellness Program for Seniors (HWePS) is a technology-enhanced, multi-level, integrated health equity intervention model that aims to promote the health and wellness of older people in an urban, low-income community. As a small-area, public-health equity program (intervention), the HWePS was designed base... | PMC9813466 | |
Objectives | Improving health equity in later life should be a top priority of public health officials, especially considering the possibility of extended later life due to increasing longevity and the proportion of older age groups. In order to advance healthy aging for all, it is imperative to reduce health disparities among olde... | PMC9813466 | ||
Methods/design | PMC9813466 | |||
Study design | The Health and Wellness Program for Seniors (HWePS) is a two-arm, non-randomized, controlled cluster trial that seeks to evaluate a theory-guided, technology-enhanced, integrated health-equity intervention model for older residents in urban, low-income communities in Seoul, Korea, during the COVID-19 pandemic. The HWeP... | PMC9813466 | ||
Study setting and participants | The HWePS is being conducted in two urban neighborhoods (Study participants include older adults residing in the intervention and control areas who consent to participate in the research study. Participants come from a pool of individuals who participated in a community-wide community health and wellness survey conduct... | PMC9813466 | ||
Intervention | PMC9813466 | |||
Process measures | The goal of process evaluation in this study is to understand the factors that can influence the success of complex interventions [Process evaluation constructs and data collection methods adapted from the UK Medical Research Council (MRC) [ | PMC9813466 | ||
Sample size and recruitment | RECRUITMENT | This HWePS intervention study is part of a larger community-wide health equity initiative, starting with a community-wide health and wellness survey conducted from November 2020 to January 2021. The sample for the community-wide survey consisted of approximately 700 older adults in the intervention area and 500 older a... | PMC9813466 | |
Assignment of interventions and blinding | Participant assignment into the intervention group or the control group is solely based on area of residence. Participants reside in 15 Considering the nature of the study, limited single-blinding is applied to the intervention, as participants will not be told whether they reside in the intervention or control area, b... | PMC9813466 | ||
Data collection | infection, mass infection | INFECTION, HAND INFECTION | Data collection is carried out by external assessors. The research team provides a one-day intensive education program consisting of survey procedures, safety and infection education, and an item-by-item explanation. The education session is followed by a Q&A session and three mandatory practice sessions with mock case... | PMC9813466 |
Data analysis plan | PMC9813466 | |||
Effect evaluation | SENSITIVITY | Descriptive statistics will be used to analyze data concerning the participants’ demographic and baseline characteristics. Baseline differences between the intervention and control group will be analyzed using an independent sample t-test or the Mann–Whitney U-test for continuous data and the Chi-square test for catego... | PMC9813466 | |
Process analysis | Quantitative data will be analyzed using simple descriptive analyses using SAS 9.4 (Cary, NC, USA), including the logs from the HWePS ICT system, the HWePS app, and the Walk-On app (a community walking tracking app) in order to monitor delivery of the intervention. We will also analyze the standardized-questionnaire it... | PMC9813466 | ||
Ethics and dissemination | This study was approved by the institutional review board (IRB) of human subjects at Seoul National University (SNU IRB 2011/002–016). No critical modifications have been made to the protocol thus far and any changes in the future will be reported to the relevant parties. All data including personal information is save... | PMC9813466 | ||
Trial status | The study has been rolled out to the intervention and control communities, and data collection is ongoing at the submission of this manuscript. Data analysis has not yet started. | PMC9813466 | ||
Discussion | infection | INFECTION | While healthy aging for all is widely accepted public health agenda, few multi-faceted, multi-level health equity interventions promoting health and wellness exist, especially ones targeting relatively healthy older adults residing in an urban, low-income community in a non-Western country. In Korea, public health cent... | PMC9813466 |
Acknowledgements | None. | PMC9813466 | ||
Authors’ contributions | WL | HK and HC conceived and initiated conceptualization and design of the study. HK, HC, YJ, JL, EK contributed to the refinement of the study design and developed implementation strategies. WL provided statistical expertise in the clinical trial design. HK, JY, HC wrote the first draft of the study protocol, and all autho... | PMC9813466 | |
Funding | DISEASE | This work was based on the Project to Empower Communities to Reduce Health Disparities, supported by the Korea Disease Control and Prevention Agency and the Seoul Metropolitan Government; the project was executed in Jungnang-gu (district) in Seoul. The funding sources had no role in the study design; data collection an... | PMC9813466 | |
Availability of data and materials | The datasets generated and/or analyzed during the current study are not publicly available due to the policy of the SNU IRB, which does not allow the opening and sharing of research data with any third party, but are available from the corresponding author upon reasonable request. | PMC9813466 | ||
Declarations | PMC9813466 | |||
Ethics approval and consent to participate | This study was approved by the institutional review board for human subjects at Seoul National University, Seoul, South Korea (SNU IRB 2011/002–016). Written informed consent is to be obtained from all study participants. | PMC9813466 | ||
Consent for publication | Not applicable. | PMC9813466 | ||
Competing interests | The authors declare that they have no competing interests. | PMC9813466 | ||
References | PMC9813466 | |||
Purpose | occlusal caries lesions | To evaluate and compare the clinical effectiveness of alkasite with nanofilled resin composite restorations for occlusal caries lesions in permanent molar teeth of children, at one-year follow-up. | PMC10317863 | |
Methods | occlusal caries lesions | In this randomized controlled clinical trial with parallel design, 38 children aged 7–13 years with occlusal caries lesions on 59 first permanent molars were randomly allocated into two groups, Group 1: Filtek™ Z350XT (nanocomposite) and Group 2: Cention N | PMC10317863 | |
Results | fracture, caries | SECONDARY, CARIES | All restorations had either Alpha or Bravo scores at one-year follow-up. In Group 1, all restorations scored Alpha, while one restoration each (3.6%) in Group 2 scored Bravo for fracture and marginal adaptation. All restorations in both groups scored Alpha for retention, secondary caries, and post-operative sensitivity... | PMC10317863 |
Conclusions | occlusal caries lesions | The performances of the nanofilled composite and alkasite were clinically acceptable and comparable. Alkasite can be an alternative material for the restoration of occlusal caries lesions in permanent molars of children. | PMC10317863 | |
Clinical trial registration | The clinical trial was registered at Clinical Trials Registry—India (CTRI Reg no: CTRI/2020/12/029830 Dated: 15/12/2020). | PMC10317863 | ||
Keywords | Open access funding provided by Manipal Academy of Higher Education, Manipal | PMC10317863 | ||
Introduction | carious lesions, fracture | Dental resin composites have gradually replaced amalgam as the standard restorative material for permanent teeth in following the principles of minimally invasive dentistry and the treaty of the Minamata Convention on Mercury in 2013 that encourages phase down of amalgam (Celik et al. Recently, an alkasite-based tooth-... | PMC10317863 | |
Material and methods | This clinical study had a randomised controlled, two-arm parallel design and is reported according to the Consolidated Standards of Reporting Clinical Trials (CONSORT) guidelines and is registered in the database for the registration of clinical studies (Clinical Trial registry of India, Reg. No.: CTRI/2020/12/029830).... | PMC10317863 | ||
Compliance with ethical Standards | The Institutional Ethics Committee approved the research protocol (Protocol Reference: 19084). Parents of the participants were informed about the procedure using a patient information sheet and written informed consent was obtained by the principal investigator. Written informed assent from the participating children ... | PMC10317863 | ||
Sample size | fracture | The sample size calculation was performed at a 90% confidence interval and power of 80%, assuming the effect size to be 25% and a failure rate (fracture of restoration) of 3% (Loguerico et al. | PMC10317863 | |
Eligibility criteria | carious lesions, pulpal disease, dentinal caries, mental disabilities, allergy, abnormal parafunctional, pain | SYSTEMIC ILLNESS, ALLERGY, HYPOPLASIA | Children aged 7–13 years, with carious lesions on the occlusal surface in any one of the first permanent molars with ICDAS score ranging from 3–5 (Ismail et al. The exclusion criteria were as follows: permanent molars with deep dentinal caries or presence of any pulpal disease with or without pain, permanent molars wit... | PMC10317863 |
Randomisation | CAVITY | Permuted block randomisation with block sizes 4 and 8 was used. Blocks were randomly allocated using a random table of numbers. An operator who was otherwise not participating in the study assigned participants to one of the groups. The allocation ratio was 1:1. The group to be assigned was marked on cards enclosed in ... | PMC10317863 | |
Clinical procedure | PLAQUE | All the restorative procedures were done under rubber dam isolation by a single operator (Principal Investigator). The included molars were cleaned, polished with non-fluoridated prophylaxis paste, rubber cup and micromotor handpiece to remove any plaque and debris. A topical anaesthetic (10% lidocaine spray) (Neon Lab... | PMC10317863 | |
Cavity preparation | carious lesion, Carious | CAVITY | Carious tissue was removed using a conservative cavity preparation method. The outline form of the cavity was defined by the extent of the carious lesion. Unsupported enamel (enamel unsupported by dentin) was preserved, while undermined enamel (thin or loose enamel) margins were removed. Extensions towards the marginal... | PMC10317863 |
Etching and bonding | Group 1: The tooth surface was etched with 3M ESPE Scotch-bond Etchant (37% phosphoric acid gel) (3M ESPE, St. Paul, MN, USA) with an applicator brush for 15 s. The tooth surface was washed with a three-way syringe for 10 s and gently dried by blotting with a mini sponge to give a moist, glistening appearance, which en... | PMC10317863 | ||
Placement of restorative material | CAVITY | For both groups, the material was placed into the cavity with help of a plastic filling instrument, followed by condensation with a composite condenser.Group 1: Composite material was placed in split horizontal increments of 1.5 mm.Group 2: Composite material was placed as a single increment. The powder and liquid of t... | PMC10317863 | |
Curing time | LED light curing device (Bluedent, BG Light Ltd, Plovdiv, Bulgaria) was used at a constant intensity of ≥ 500 mW/cm | PMC10317863 | ||
Evaluation | After one year, the restorations were evaluated by two examiners who were previously trained and calibrated, using Modified Ryge/USPHS (United States Public Health Service) criteria (Bayne and Schmalz | PMC10317863 | ||
Calibration of examiners | Both the examiners were trained and calibrated for the USPHS criteria before the evaluation of the restorations (Table Description of the criteria for clinical evaluation of the restorations at follow-up using the USPHS criteria (modified from Canali et al. | PMC10317863 | ||
Blinding | The study participants, the examiners who performed the follow-up examination and the statistician who carried out the analysis were blinded to group allocation. However, the operator who had carried out the restorative procedures was not blinded to the group allocation. | PMC10317863 | ||
Statistical analysis | Data were entered and analyzed using IBM SPSS Statistics for Windows, version 20 (IBM, Armonk, NY, USA). Descriptive statistics were tabulated. The baseline data and the outcomes were compared between the groups using the Students | PMC10317863 | ||
Results | At the beginning of the study, 38 children with 59 erupted first permanent molars were recruited from December 2020 to February 2021(Fig. Flow diagram representing flow of participants until 12 months in the studyComparison of Mean Age, Baseline Mean DMFT and dmft scores between the groupsComparison of frequencies of v... | PMC10317863 | ||
Discussion | Loss of retention, fracture, bond failure, tooth | ADHESION | In this study, two different classes of resin composites were utilised for the restoration of occlusal surfaces of the first permanent molars in paediatric dental patients. The clinical effectiveness of a nanofill (Filtek™ Z350XT) resin composite was compared with an alkasite (Cention NDespite both groups demonstrating... | PMC10317863 |
Author contributions | RS | Conceptualization, methodology: HS, BSS, RS; Investigation: HS, BSS, RS; Data curation: HS and BSS; Statistical Analysis: RS and HK; Writing—original draft preparation: HS and BSS; Writing—review and editing: RS, HK and AR; Supervision: BSS. All authors read and approved the final manuscript. | PMC10317863 | |
Funding | Open access funding provided by Manipal Academy of Higher Education, Manipal. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. | PMC10317863 | ||
Data availability | The data that support the findings of this study are available from the corresponding author upon reasonable request. | PMC10317863 | ||
Declarations | PMC10317863 | |||
Conflict of interest | The authors declare that they have no conflict of interest. | PMC10317863 | ||
Ethics approval | The Institutional Ethics Committee of Manipal College of Dental Sciences, Mangalore, approved this study (Protocol Reference: 19084). The study was performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki (2013 amendment). | PMC10317863 | ||
Consent to participate | The authors confirm that written informed consent was obtained from all the parents of the children included in the study, and written informed assent was obtained from all the children who participated in the study, with the information provided on participation and publication of data. | PMC10317863 | ||
References | PMC10317863 | |||
Background | NSCLC | NON-SMALL CELL LUNG CANCER, PULMONARY METASTASIS, NSCLC | Prognostic factors and survival outcomes of non-small cell lung cancer (NSCLC) with Ipsilateral pulmonary metastasis (IPM) are not well-defined. Thus, this study intended to identify the prognostic factors for these patients and construct a predictive nomogram model. | PMC10614355 |
Methods | REGRESSION | One thousand, seven hundred thirty-two patients with IPM identified between 2000 to 2019 were from the Surveillance, Epidemiology, and End Results (SEER) database. Independent prognostic factors were identified using multivariate Cox regression analyses. Nomograms were constructed to predict the overall survival (OS), ... | PMC10614355 | |
Results | Patients were randomly divided into training ( | PMC10614355 | ||
Conclusion | NSCLC | NSCLC | We constructed and internally validated a nomogram to predict 1-year, 3-year, and 5-year OS for NSCLC patients with IPM according to independent prognostic factors. This nomogram demonstrated good calibration, discrimination, clinical utility, and practical decision-making effects for the prognosis of NSCLC patients wi... | PMC10614355 |
Keywords | PMC10614355 | |||
Introduction | NSCLC, tumor, tumors | NON-SMALL CELL LUNG CANCER, TUMOR, METASTASIS, PULMONARY METASTASIS, MALIGNANT TUMOR, NSCLC, PRIMARY TUMOR, TUMORS | Ipsilateral pulmonary metastasis (IPM), also known as separate or additional tumor nodule(s), is a form of intrapulmonary metastasis in non-small cell lung cancer (NSCLC), including tumors with additional nodule(s) in the same lobe (PM1) and tumors with additional nodule(s) in the ipsilateral different lobe (PM2) [Alth... | PMC10614355 |
Methods | PMC10614355 | |||
Data sources | cancer | CANCER | One thousand, seven hundred thirty-two patients with IPM were identified between 2000 to 2019 from the database "Incidence – SEER Research Plus Data, 17 Registries, Nov 2021 Sub (2000–2019)”. The SEER database was publicly available and established in 1973. The database currently collects and publishes cancer incidence... | PMC10614355 |
Patient selection | NSCLC, non-small-cell carcinoma, tumor, Tumor, pulmonary metastasis, adenocarcinoma, primary lung cancer | NON-SMALL CELL LUNG CANCER, TUMOR, LUNG, TUMOR, PULMONARY METASTASIS, ADENOCARCINOMA, NSCLC, SQUAMOUS CELL CARCINOMA, LARGE CELL CARCINOMA | The inclusion criteria were: (1) primary lung cancer; (2) tumor descriptor with ipsilateral pulmonary metastasis [based on Separate Tumor Nodules Ipsilateral Lung Recode (2010 +) with the information of separate nodules of the same hist type in the ipsilateral lung, same or different lobe]; (3) no overlapping primary s... | PMC10614355 |
Statistical analysis | Random division of patients, all analyses and figures were performed by R version 4.2.2 and R studio 2022.12.0 Build 353 ( | PMC10614355 | ||
Results | PMC10614355 | |||
Construction and validation of nomogram for predicting OS | NSCLC, tumor | NON-SMALL CELL LUNG CANCER, TUMOR, PRIMARY TUMOR, NSCLC, REGRESSION | Based on the results of the multivariate Cox regression model, a nomogram was constructed using independent factors including age, sex, primary tumor size, tumor grade, N status, number of regional lymph nodes removed, and chemotherapy. The nomogram can predict the 1-year, 3-year, and 5-year OS rates by summing the poi... | PMC10614355 |
Discussion | NSCLC, tumor, Tumor, lung cancer, tumors | NON-SMALL CELL LUNG CANCER, TUMOR, METASTASIS, TUMOR, LYMPH NODE METASTASES, LUNG CANCER, NSCLC, PRIMARY TUMOR, TUMORS | IPM is a heterogeneous category in NSCLC and survival outcomes can be affected by various factors [Our data suggest that patients over 65 years old have a worse prognosis, which is consistent with other studies on lung cancer [Tumor size is a well-known prognostic factor for NSCLC, and larger tumors have a greater risk... | PMC10614355 |
Conclusion | NSCLC, tumor | PRIMARY TUMOR, TUMOR, NSCLC | In conclusion, age, sex, primary tumor size, N status, number of regional lymph nodes removed, tumor grade, and chemotherapy of patients were the independent prognostic factors for NSCLC patients with IPM. We constructed and internally validated a nomogram to predict 1-year, 3-year, and 5-year OS for NSCLC patients wit... | PMC10614355 |
Acknowledgements | We thank the Surveillance, Epidemiology, and End Results database ( | PMC10614355 | ||
Authors’ contributions | Jiajun Zhang: conception and design, preparation of the manuscript, and analysis of the data. Jin Zhang: design and review. | PMC10614355 | ||
Funding | No funding. | PMC10614355 | ||
Availability of data and materials | All data and documents needed will be provided upon request through email: 361532004@qq.com. | PMC10614355 | ||
Declarations | PMC10614355 | |||
Ethics approval and consent to participate | cancer, Cancer | CANCER, CANCER | We promise that our research was performed in accordance with the Declaration of Helsinki and all methods were carried out in accordance with relevant guidelines and regulations. All experimental protocols were approved by the ethics committee of National Cancer Institute (USA) to obtain research data on cancer patient... | PMC10614355 |
Consent to publication | Not applicable. | PMC10614355 | ||
Competing interests | The authors declare no competing interests. | PMC10614355 | ||
References | PMC10614355 | |||
Background: | coronavirus disease | CORONAVIRUS, SEVERE ACUTE RESPIRATORY SYNDROME | In individuals with coronavirus disease (COVID-19), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral load (VL) plays an important role in infectivity. | PMC10326526 |
Objectives: | This study aimed to evaluate the reduction in the VL and infectivity induced by phthalocyanine mouthwash and nasal spray in patients with COVID-19. | PMC10326526 | ||
Methods: | Patients with mild COVID-19 were recruited to participate in a triple-blinded randomized controlled trial. Participants were assigned to one of three groups: Group 1, non-active mouthwash and saline nasal spray (SNS); Group 2, phthalocyanine mouthwash and SNS; and Group 3 phthalocyanine mouthwash and phthalocyanine na... | PMC10326526 | ||
Findings: | Forty-six participants were included in the analysis: 15, 16, and 15 in Groups 1, 2, and 3, respectively. After 72 hours, the reduction in VL was significantly higher in Group 3 (mean cycle threshold (Ct) decrease: 11.21) than in Group 1 (mean Ct decrease: 5.53). Additionally, only the mean VL in Group 3 was reduced t... | PMC10326526 | ||
Main conclusions: | Use of phthalocyanine mouthwash and nasal spray is effective at reducing SARS-CoV-2 infectivity. | PMC10326526 | ||
Zusammenfassung | PMC10326526 | |||
Hintergrund: | CORONAVIRUS | Bei Personen mit Coronavirus-Erkrankung (COVID-19) spielt die Viruslast (VL) des schweren akuten respiratorischen Syndroms Coronavirus 2 (SARS-CoV-2) eine wichtige Rolle für die Infektiosität. | PMC10326526 |
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