title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Intervention | CDA, COLD | As part of the standard of care, all livers were preserved by static cold storage following classic organ procurement. All liver grafts were flushed with 1 L of Institut Georges Lopez (IGL-1) preservation solution through the portal vein ex situ at the end of the back-table preparation at the recipient center. All tran... | PMC9975910 | |
End Point Measures | postreperfusion syndrome, liver IRI | The primary end point was defined as the difference between the 2 study arms in peak serum aspartate aminotransferase (AST) levels within the first 72 hours after graft reperfusion, an accepted clinical surrogate of liver IRI that correlates with patient and graft survival and postreperfusion liver histological assessm... | PMC9975910 | |
Safety | ADVERSE EVENTS | All adverse events were prospectively collected in both groups, categorized as adverse events or serious adverse events, and adjudicated for a possible causal relationship with the treatment. Treatment-related adverse events were considered within the first 7 days following transplant. | PMC9975910 | |
Statistical Analysis | AKI, postreperfusion syndrome, DCD liver | REGRESSION, SECONDARY, SURGICAL COMPLICATIONS | A sample size of 58 patients was needed to detect a 50% reduction in peak AST, as determined with a 2-sided, 2-sample pooled Results for the primary end point are reported for the full analysis set and a per protocol set. For secondary outcomes, the results for the per protocol set are given.For the primary end point, ... | PMC9975910 |
Results | PMC9975910 | |||
Recruitment | Between September 2013 and February 2018, 310 consecutive patients were screened for the trial ( | PMC9975910 | ||
Flow Diagram of Enrollment, Randomization, and Follow-up of Patients | CDA | CDA indicates combined drug approach. | PMC9975910 | |
Donor, Preservation, and Recipient Demographics | Overall, the 2 study arms were balanced with respect to donor and recipient demographics and baseline characteristics ( | PMC9975910 | ||
Baseline Donor and Graft Preservation Characteristics and Recipient Characteristics | HCC,, death, HCV, hepatitis C, ischemia, NASH, hepatocellular carcinoma, End-stage Liver Disease | HEPATITIS B, VIRUS, CIRCULATORY ARREST, ISCHEMIA, BRAIN DEATH, NONALCOHOLIC STEATOHEPATITIS, CEREBROVASCULAR ACCIDENT, CDA, COLD | Abbreviations: CDA, combined drug approach; CIT, cold ischemia time; CVA, cerebrovascular accident; DBD, donation after brain death; DCD, donation after circulatory death; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HTK, histidine tryptophan ketoglutarate; ICU, intensive care unit; IG... | PMC9975910 |
Primary End Point | CDA | In the per protocol analysis, the peak AST level within the first 72 hours following reperfusion was not different in the CDA group compared with the control group both without adjustment for CIT and MELD score (geometric mean, 1262.9 U/L [95% CI, 946.3-1685.4 U/L] vs 1451.2 U/L [95% CI, 1087.4-1936.7 U/L]; geometric m... | PMC9975910 | |
Primary and Secondary End Points | acute kidney injury, ischemia-reperfusion injury | EVENTS, CDA, BRAIN DEATH | Abbreviations: AST, aspartate aminotransferase; CDA, combined drug approach; DBD, donation after brain death; FAS, full analysis set; IRI, ischemia-reperfusion injury; ND, not determined because of an absence of events in 1 group; PPS, per protocol set analysis.SI conversion factor: To convert AST to μkat/L, multiply b... | PMC9975910 |
Secondary End Points | AKI, postreperfusion syndrome | SURGICAL COMPLICATIONS | There was no difference in the IRI score or frequencies of postreperfusion syndrome, EAD, severe surgical complications, IC, AKI, and acute cellular rejection between arms ( | PMC9975910 |
One-year Cumulative Patient Mortality and Graft Loss in the Combined Drug Approach (CDA) and Control Groups | PMC9975910 | |||
Safety and Adverse Events | CDA, ADVERSE EVENT | A significant difference in the proportion of patients with at least 1 serious adverse event was not observed between groups (10 of 36 [27.8%] in the CDA group and 8 of 36 [22.2%] in the control group; | PMC9975910 | |
Discussion | AKI, biliary complications | CDA, SURGICAL COMPLICATIONS, COLD, SYNDROME | In this RCT, we did not find evidence that an add-on perioperative combination drug regimen delivered to the graft immediately before implantation and to the recipient attenuated the degree of IRI. In addition, no differences were found in postreperfusion syndrome, histological IRI score, liver function, and the freque... | PMC9975910 |
Limitations | CDA | This study has some limitations. First, it was a single-center RCT. Second, individual effects of each component of the CDA in decreasing IRI were not assessed separately. As the CDA specifically aims to achieve synergistic effects, the parallel testing of individual drugs was considered not useful and, in the clinical... | PMC9975910 | |
Conclusions | CDA, COLD | In this RCT, we did not find evidence that a combined drug approach targeting the post–cold storage graft and the recipient was sufficient to decrease IRI. Targeting the graft before and/or during preservation may also be necessary. The advent of dynamic preservation may bring the opportunity to combine a downstream CD... | PMC9975910 | |
Background | ® | The FAKHRAVAC®, an inactivated SARS-CoV-2 vaccine, was assessed for safety and immunogenicity in a phase II trial. | PMC9951829 | |
Methods | ADVERSE EVENTS | We did a phase II, single-centered, randomized, double-blind, placebo-controlled clinical trial of the FAKHRAVAC inactivated SARS-CoV-2 vaccine on adults aged 18 to 70. The two parallel groups received two intramuscular injections of either a 10-µg vaccine or a placebo at 2-week intervals. The participants' immunogenic... | PMC9951829 | |
Results | tenderness, headache | ADVERSE REACTION | Five hundred eligible participants were randomly (1:1) assigned to vaccine or placebo groups. The median age of the participants was 36 years, and 75% were male. The most frequent local adverse reaction was tenderness (21.29% after the first dose and 8.52% after the second dose), and the most frequent systemic adverse ... | PMC9951829 |
Supplementary Information | The online version contains supplementary material available at 10.1186/s12879-023-08079-1. | PMC9951829 | ||
Keywords | PMC9951829 | |||
Introduction | Different vaccine platforms have been used to develop vaccines against SARS-CoV-2 [FAKHRAVAC is an inactivated vaccine that was developed early in the course of the COVID-19 pandemic. The vaccine seed was isolated from Iranian inpatient COVID-19 cases in March 2020 and cultivated using Vero cells. A fast protein liquid... | PMC9951829 | ||
Methods | PMC9951829 | |||
Study design and setting | We did a phase II, single-centered, randomized, double-blind, parallel groups, placebo-controlled clinical trial of FAKHRAVAC inactivated SARS-CoV-2 vaccine on adults aged 18 to 70. The study protocol was approved by the National Ethics Committee for Research in Medical Sciences (approval number IR.NREC.1400.003, June ... | PMC9951829 | ||
Participants | malignancy, allergic diseases | MAY, DISEASES, RECRUITMENT | Participants were enrolled through a website between May and July 2021. Following declaration of willingness to participate in the trial and an initial online screening, potentially eligible volunteers were invited to attend the trial unit for further psychological, clinical, and laboratory evaluations and to sign a wr... | PMC9951829 |
Randomization and masking | CRF | CRF | We used permuted block randomization to allocate eligible participants to the vaccine and placebo groups. Block sizes of four were used and each block contained an equal number of alternative interventions. Rand function in excel was used to generate the random sequence within each block. Randomly generated four-digit ... | PMC9951829 |
Procedures | ADVERSE EVENTS | Participants received two intramuscular injections of either a 10-µg vaccine or a placebo (an adjuvant-only preparation) at 2-week intervals. FAKHRAVAC inactivated vaccine was made of SARS-CoV-2 strains isolated from the oropharyngeal Swabs of Iranian hospitalized patients replicated using Vero cells (Cat. # 88020401),... | PMC9951829 | |
Outcomes | diarrhea, fatigue, nausea and vomiting, erythema, pain, muscle pain, headache, tenderness, anaphylactic reactions | ADVERSE EVENT, VIRUS, ANAPHYLACTIC REACTION, ADVERSE EVENTS, ERYTHEMA, SECONDARY, HAND SWELLING, ADVERSE REACTION | Our primary safety outcomes were immediate anaphylactic reactions following vaccination and local and systemic adverse events during the week after receiving each vaccine/placebo dose. Participants were kept under close observation in the trial unit for 3 h following vaccination and their vital signs were monitored hou... | PMC9951829 |
Statistical analysis | Based on expert opinion, a sample of 500 volunteers was used for phase II (for participants flow diagram and exclusions see Fig. Participant flow diagram of participants | PMC9951829 | ||
Role of funding source | The sponsor conducted the immunogenicity tests. The research team coded the serum specimens and concealed their labels before sending them to the lab. The sponsor had no role in data collection, management, analysis, interpretation, and writing of the report. | PMC9951829 | ||
Discussion | ®, COVID-19 disease | ADVERSE EVENTS, DISEASE, ADVERSE REACTION, ASYMPTOMATIC COVID-19 | We found that the 10-µg FAKHRAVAC inactivated SARS-CoV-2 vaccine elicited significant neutralizing antibody response about six times the placebo group (and nine times to the baseline) four weeks after the second dose. Specific antibodies against S and RBD using the ELIZA method also showed a more than three times incre... | PMC9951829 |
Acknowledgements | This work was supported by the Milad Daro Noor Pharmaceutical (MDNP) Company. The immunology lab and all other research staff involved in collecting and examining blood samples taken for immunogenicity assessment were masked to the identity of the participants and the allocated interventions. The study was overseen by ... | PMC9951829 | ||
Author contributions | ASH | AA: MSD: Conceptualization, methodology, data Curation, visualization. PB, MM, AJ, FGH, KG, AA, MA, ZR, MSD: Writing original-draft preparation, writing—review and editing, methodology, project administration, supervision, conceptualization. RHF, AKR, KN, MF, SGH, PKH, MH, SKH, MSH, HM, SM, BSH, HA, AM, AKH: Resource. ... | PMC9951829 | |
Funding | Milad Daro Noor Pharmaceutical (MDNP) Company provided the funding for this study and the logistics for study conduct but had no role in data management, analysis, interpretation, or writing the report. The grant number of this study is not applicable. | PMC9951829 | ||
Availability of data and materials | Data are available on reasonable request. Individual participant data will be made available when the trial is complete on requests directed to the corresponding author; after the approval of a proposal, data can be shared through a secure online platform. | PMC9951829 | ||
Declarations | PMC9951829 | |||
Ethics approval and consent to participate | The trial was conducted in accordance with the 1964 Helsinki Declaration and its later amendments. The clinical trial protocol was approved by the Iranian National Ethics Committee for research (approval number IR. NREC.1400.003, 7th June 2021). Informed consent was obtained from all participants. | PMC9951829 | ||
Consent for publication | Not applicable. | PMC9951829 | ||
Competing interests | ASH | SGH, PKH, MH, SKH, MSH, HM, SM, BSH, HA, AM, and AKH are employees of Milad Daro Noor Pharmaceutical (MDNP). MSD is an Iran University of Medical Science (IUMS) employee. MSD, AA, MA, ASH, ZR, FGH, and KG are members of the clinical trial center of the Iran University of Medical Science that acted as academic CRO. All ... | PMC9951829 | |
References | PMC9951829 | |||
Aim | tremor | The purpose of this study was to determine whether a low-tremor side-bridge exercise for 4 weeks improves bow tremor during archery movements. | PMC10150967 | |
Methods | tremor | Participants were 20 male college students. First, we measured the tremor during side bridges performed with trunk inclinations of 25°, 40°, 55°, and 70° using an accelerometer attached to the elbow joint and identified low-tremor side bridges. The participants were then randomly divided into intervention and non-inter... | PMC10150967 | |
Results | tremor | The effect of the intervention was determined by measuring the total tremor value using an accelerometer attached to the bow and changes in the median power frequency (MdPF) of the middle deltoid, upper trapezius, and lower trapezius. This intervention reduced the bow tremor and the median power frequency of the middle... | PMC10150967 | |
Conclusions | tremor | The findings suggested that the tremor during the archery sighting phase could be reduced by performing side bridges with a specific trunk angle for a certain period of time. This intervention was also shown to reduce the intermediate frequency of the middle deltoid. The reduced tremor can shorten the sighting phase, w... | PMC10150967 | |
Data Availability | All relevant data are within the manuscript and its | PMC10150967 | ||
Introduction | bowstring, tremor, shoulder girdle, tremors | SAID | Archery is a sport enjoyed by millions of people of all ages and abilities worldwide, including people with physical mobility limitations in adaptive recreational or school physical education programs [An archery shot primarily consists of three phases: 1) the stance phase; 2) the arming phase, during which the archer ... | PMC10150967 |
Materials and methods | PMC10150967 | |||
Participants | injuries, dislocation, collegiate, pain | Twenty male collegiate students (20.8 ± 0.3, range: 20–23) participated in this study. All participants were inexperienced in archery. A completed and signed informed consent form was obtained from each participant before the study. The study protocol was approved by the Ethics Committee of the Takarazuka University of... | PMC10150967 | |
Characteristics of the participants in this study. | PMC10150967 | |||
Archery task | bow-side shoulder joints, abduction | All 20 participants used a 9-kg (20 lb.) bow to perform archery shooting. The posture in this task was set to 90° abduction of bow-side shoulder joints ( | PMC10150967 | |
Posture during archery task. | A is the frontal plane and B is the horizontal plane. | PMC10150967 | ||
Selection of trunk inclination during the side-bridge exercise | tremor | Eleven participants were included in this study. The side bridge exercise was performed for 15 seconds in each of the four conditions and arm tremor was analysed. Since all participants were right-handed, they performed the exercise with their left hand holding a bow during archery shooting. For all side-bridge exercis... | PMC10150967 | |
Four conditions used in the side-bridge exercise. | Cond1, cond2, cond3, and cond4 represent trunk inclinations of 25°, 40°, 55°, and 70°, respectively. | PMC10150967 | ||
Exercise intervention | The intervention group exercised 5 days a week for 4 weeks, for a total of 20 days. The exercise was a side bridge performed with a trunk inclination of 40°, which was judged to be the most effective of the four side-bridge exercises (Figs | PMC10150967 | ||
The side-bridge exercise performed in the intervention. | The height of the Bow-side hand was adjusted and the trunk inclination angle was 40 degrees. A non-slip mat was used for the floor and the stand. | PMC10150967 | ||
Data analysis | PMC10150967 | |||
Analysis of tremor | tremor | For the Bow tremor measurement, the accelerometers were fixed to the handle with taping. To measure arm tremor, the accelerometers were fixed to the lateral epicondyle of the humerus with taping. Bow and arm tremor were measured using accelerometers (OE-WS2521; Oisaka, Hiroshima, Japan) fixed to the handle of the bow b... | PMC10150967 | |
Muscle activity analysis | Bipolar surface electrodes (OE-WS2521; Oisaka, Hiroshima, Japan) were placed on three scapulothoracic muscles (the upper and lower trapezius and the serratus anterior) and a scapulohumeral muscle (deltoid middle) in accordance with previously published standardized methods [The frequency band for the analysis was 1–100... | PMC10150967 | ||
Statistical analysis | Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, USA) version 20.0 J for Windows®. The Steel-Dwass method was used for statistical evaluations. The baseline values of the intervention and the non-intervention groups were compared using Welch’s t-test. A p... | PMC10150967 | ||
Results | PMC10150967 | |||
Verification of optimal trunk inclination at the time of the side-bridge exercise | tremor | The arm tremor values were 0.00022 ± 0.00018(m/s | PMC10150967 | |
Comparison of tremors during side-bridge exercise. | PMC10150967 | |||
Comparison of baseline values between the intervention and non-intervention groups | tremor | The baseline age, height, body weight, and BMI were not significantly different between the intervention and non-intervention groups. The two groups also showed no significant differences in baseline tremor intensity and MdPF values for the middle deltoid, upper trapezius, lower trapezius, and serratus anterior muscles... | PMC10150967 | |
Comparison of values before and after the intervention | tremors | Measurements obtained during shooting movements at baseline and after 4 weeks in the intervention group were compared, and significant differences were observed in the intensity of tremors and the MdPF of the middle deltoid ( | PMC10150967 | |
Comparison between the findings at baseline and 4 weeks in the intervention group. | PMC10150967 | |||
Comparison between the findings at baseline and 4 weeks in the non-intervention group. | PMC10150967 | |||
Discussion | abduction of the shoulder joint, tremor, Tremors, tremors, muscle hypertrophy | In the arming phase of archery shooting, fast muscle fibre activity is required to pull the strings strongly, and in the sighting phase, the target must be aimed while keeping the strings pulled out. In this study, we hypothesized that the activity of slow muscle fibres was necessary to reduce bow tremor in the sightin... | PMC10150967 | |
Conclusions | tremors, trauma | The findings of this study may provide an effective training method for athletes who cannot control their tremors during shooting movements, such as beginner archers and those experiencing yips. In future research, we would like to verify the appropriate load, such as the angle of the trunk and exercise time for actual... | PMC10150967 | |
Supporting information | PMC10150967 | |||
Selection of trunk inclination during the side-bridge exercise. | The code was written using Python.(TXT)Click here for additional data file. | PMC10150967 | ||
Exercise intervention. | The code was written using Python.(TXT)Click here for additional data file.The authors express their appreciation to Mr. Atsuhiro Toda and Mr. Shinji Kanegawa for supporting this research. We would like to thank Editage ( | PMC10150967 | ||
References | PMC10150967 | |||
1. Introduction | cardiovascular and/or metabolic diseases, death, hypertensive, cardiovascular or metabolic disease | DISEASES, HIGH BLOOD PRESSURE, CARDIOVASCULAR DISEASE, HBP | Background: High blood pressure is an important public health problem due to its high prevalence, the difficulty to control it, and its high contribution to morbidity. A series of changes may be linked to the aging process, compromising cardiac conduction, and reducing cardiovascular baroreceptor function. Advancing ag... | PMC9859152 |
2. Materials and Methods | PMC9859152 | |||
2.1. Study Design | knee osteoarthrosis, musculoskeletal disorders, cardiovascular and/or metabolic diseases, neurological diseases, cardiovascular and/or metabolic disease | CARDIAC EVENT, NEUROLOGICAL DISEASE, LUNG DISEASE, HBP, KNEE OSTEOARTHROSIS, LUNG DISEASES, RECRUITMENT, PULMONARY DISEASES, MUSCULOSKELETAL DISORDERS, HIGH BLOOD PRESSURE, HYPERTENSIVE CRISIS | Our study was a non-randomized controlled study conducted from June 2014 to June 2016 in a rehabilitation clinic for the elderly, located in the state of São Paulo, Brazil, where participants already practiced regular physical activity (practice light or moderate intensity physical activities for about 20 min a day). W... | PMC9859152 |
2.2. Instruments and Data Collection | After signing the Informed Consent Forms, an anamnesis form was used to measure anthropometric variables such as weight and height, and clinical history.We controlled the ambient temperature (between 21 °C and 23 °C) and humidity (between 40 and 60%), and prepared the equipment before participants arrived at the testin... | PMC9859152 | ||
2.3. Analysis of Heart Rate Variability | PMC9859152 | |||
2.3.1. Time Domain (TD) | In the time domain, the statistical parameters used to determine the corresponding RR intervals at any point in time [The triangular index (RRTri) was calculated from a density histogram of the normal RR intervals. The RRtri index was calculated from the density histogram of the normal RR intervals, obtained by dividin... | PMC9859152 | ||
2.3.2. Frequency Domain (FD) | We used the spectral components low frequency (LF), high frequency (HF) in ms squared, and LF/HF ratio for the analysis of HRV in the frequency domain. To obtain the spectral indices, the frequency tachogram undergoes mathematical processing and creates a graph that expresses the variation of RR intervals as a function... | PMC9859152 | ||
2.4. Statistical Analysis | HBP | Data are presented as group mean values and standard deviations. A multivariate analysis of variance (MANOVA) was used to analyze differences between study groups in all baseline variables. ExcelANOVA analysis of dependent variables were used for the HBP and control groups by five moments (rest, exercise, R1, R2, and R... | PMC9859152 | |
3. Results | HIGH BLOOD PRESSURE, HBP | There were 84 participants into the study, 42 in the control group and 42 in the HBP group. Baseline characteristics of those groups are described in MANOVA revealed significant effects for groups [Wilks’ lambda = 0.220, F12, 71 = 20.94, The main effect for groups was found only for mean RR, suggesting that the mean RR... | PMC9859152 | |
4. Discussion | impairment of the HRV, cardiovascular and metabolic diseases, hypertensive, cardiovascular or metabolic pathologies, hypertension | HBP, CARDIOVASCULAR DISEASES, METABOLIC DISEASES, EVENTS, HYPERTENSION, HIGH BLOOD PRESSURE | The interpretations of our results suggest that there was no difference in the autonomic modulation of HR between the elderly participants without cardiovascular and metabolic diseases (the control group), and the hypertensive group. However, there was a reduction in parasympathetic modulation between the pre-exercise ... | PMC9859152 |
Limitations | injuries, hypertensive | COMPLICATIONS, HBP | The hypertensive elderly participants evaluated in this study were physically active, clinically able to practice physical activity, and had controlled HBP. Thus, our results do not provide information on the heart variability of hypertensive elderly in advanced stages, whose injuries may be more severe. Furthermore, s... | PMC9859152 |
5. Conclusions | cardiovascular and metabolic diseases, hypertensive | There was no difference in autonomic modulation and global heart rate variability between elderly people without cardiovascular and metabolic diseases and hypertensive elderly people after a bout of aerobic exercise. The elderly in the control group showed a decrease in parasympathetic modulation and global variability... | PMC9859152 | |
Author Contributions | Conceptualization, P.E.d.A. and R.D.R.; methodology, P.E.d.A., J.Z.-R. and R.D.R.; validation, all authors.; formal analysis, J.Z.-R. and T.C.M.; investigation P.E.d.A., I.C.E.S. and R.D.R.; resources, P.E.d.A. and R.D.R.; data curation, P.E.d.A., J.M.S.J. and R.D.R.; writing—original draft preparation, all authors; wr... | PMC9859152 | ||
Institutional Review Board Statement | The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of ABC Medical School (CAEE protocol 02830612.1.0000.0082/#108.260) and Brazilian Registry of Clinical Trials (#RBR-5mgrttm). | PMC9859152 | ||
Informed Consent Statement | Informed consent was obtained from all subjects involved in the study. | PMC9859152 | ||
Data Availability Statement | The data of this work can be requested from the corresponding author (email: | PMC9859152 | ||
Conflicts of Interest | The authors declare no conflict of interest. | PMC9859152 | ||
References | Baseline characteristics of participants according to sex, age, height, weight, body mass index, smoking, blood pressure, and heart rate.Data are expressed as mean and standard deviation. Analyzed by a Fisher test and | PMC9859152 | ||
Background | bipolar disorder | The impairing neurodevelopmental course of bipolar disorder (BD) suggests the importance of early intervention for youth in the beginning phases of the illness. | PMC10324335 | |
Objective | We report the results of a 3-site randomized trial of family-focused therapy for youth at high-risk (FFT-HR) for BD, and explore psychosocial and neuroimaging variables as mediators of treatment effects. | PMC10324335 | ||
Methods | depressive disorder, active mood symptoms | High-risk youth (<18 years) with major depressive disorder or other specified BD, active mood symptoms, and a family history of BD were randomly assigned to 4 months of FFT-HR (psychoeducation, communication and problem-solving skills training) or 4 months of enhanced care psychoeducation. Adjunctive pharmacotherapy wa... | PMC10324335 | |
Results | ideation | Among 127 youth (mean 13.2 ± 2.6 years) over a median of 98 weeks, FFT-HR was associated with longer intervals prior to new mood episodes and lower levels of suicidal ideation than enhanced care. Reductions in perceived family conflict mediated the effects of psychosocial interventions on the course of mood symptoms. A... | PMC10324335 | |
Conclusion | FFT-HR may delay new mood episodes in symptomatic youth with familial liability to BD. Putative treatment mechanisms include neural adaptations suggestive of improved emotion regulation. | PMC10324335 | ||
Clinical Trial Registration Information | Bipolar Disorder | Early Intervention for Youth at Risk for Bipolar Disorder; | PMC10324335 | |
Keywords | PMC10324335 | |||
INTRODUCTION | manic, anxiety, mood disorders, Bipolar disorder, mood instability, hyperactivity, mania, depressive, hypo/mania, hypomania, depressive symptoms, bipolar | RECURRENCES, REMISSION | Bipolar disorder (BD) can be recognized in childhood and adolescence, typically in the form of depressive symptoms or episodes, subsyndromal mania or hypomania, anxiety, and mood instability [The developmental pathways to the onset of BD in vulnerable youth are being clarified in genetic, neuroimaging, and psychosocial... | PMC10324335 |
METHODOLOGICAL APPROACH: DESIGN OF THE TRIAL | PMC10324335 |
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