title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Measures | All participants received an email with a link to an online assessment battery at baseline, postintervention and 3 months follow-up. None of the research team had access to these data prior to the final analysis, ensuring independence of assessments. | PMC10577780 | ||
Primary outcome | depressive, Depression, Anxiety, anxiety | We assessed the primary outcomes of anxiety and depressive symptoms with the Hospital Anxiety and Depression Scale (HADS | PMC10577780 | |
Secondary outcomes | Anxiety, worry, anxiety | DISORDER | Generalised anxiety and worry were assessed with the Generalised Anxiety Disorder Scale (GAD-7 | PMC10577780 |
Statistical analyses | The sample size was calculated on the basis of prior trials of group-based interventions delivered during the pandemic,We assessed potential differences between participants across treatment arms using planned t-tests for continuous measures and χ | PMC10577780 | ||
Results | PMC10577780 | |||
Baseline characteristics of participants | anxiety disorder, Anxiety, anxiety, caseness, Insomnia, depression, Depression | DISORDER, DISORDER | Between 10 December 2020 and 16 September 2021 (with final 3-month follow-up assessment completed on 18 February 2022), 174 participants were enrolled into the trial. The majority of participants were female (83.9%), and were university educated (71.3%). In terms of caseness of psychological problems, 85.1% met the cut... | PMC10577780 |
Primary outcome | Anxiety, anxiety, Suicidality, Suicidal Ideation, depression, Depression | DISORDER, SECONDARY, POSITIVE | At 3 months participants in the intervention arm reported greater reductions in depression on the HADS (mean difference 1.2 (95% CI 0.4 to 1.9), p=0.003), with a moderate effect size (0.5 (95% CI 0.2 to 0.9)). There was no between-group difference on anxiety on the HADS (Summary statistics and results from mixed model ... | PMC10577780 |
Secondary outcomes | In terms of suicidality, the intervention led to greater reduction difference at 3-month follow-up (mean difference 4.8 (95% CI 1.32 to 8.4), p=0.008), indicating a moderate effect size (0.4 (95% CI 0.1 to 0.8) ( | PMC10577780 | ||
Subgroup analyses | depression, anxiety | There were 148 participants who reported probable depression or anxiety at baseline; these were equally distributed between the intervention (77, 88.5%) and EUC (71 (81.6%). In terms of analyses that focused on these participants ( | PMC10577780 | |
Sensitivity analyses | suicidality, depression | ADVERSE EVENTS | The sensitivity analysis that focused only on participants who completed the 3-month follow-up indicated that in terms of primary outcomes, the intervention led to greater reductions than EUC for depression and suicidality, and greater increase in quality of life (There were no adverse events throughout the trial. | PMC10577780 |
Data availability statement | Data are available on reasonable request. Data will be available for meta-analysis and other reasonable requests from RB (r.bryant@unsw.edu.au) | PMC10577780 | ||
Ethics statements | PMC10577780 | |||
Patient consent for publication | Not applicable. | PMC10577780 | ||
Ethics approval | This study was approved by University of New South Wales Human Research Ethics Committee (HC200670). Participants gave informed consent to participate in the study before taking part. | PMC10577780 | ||
References | PMC10577780 | |||
Background | autistic, Autistic, Autistic Traits | Autistic people demonstrate focused interests, sensitivity to sensory stimulation, and, compared with the general population, differences in social communication and interaction. We examined whether a combination of the Awareness and Care for My Autistic Traits (ACAT) program and treatment-as-usual is more effective th... | PMC10485995 | |
Methods | autistic, Autism | SECONDARY, BLIND | Forty-nine adolescents and their parents/guardians were randomly assigned to either a combination of ACAT and treatment-as-usual or only treatment-as-usual. The combined group received six weekly 100-minute ACAT sessions, while the treatment-as-usual group received no additional intervention. The primary outcome was th... | PMC10485995 |
Results | Autistic, autistic adolescents, Autism | The combined group (both autistic adolescents and their parents/guardians) showed an increase in Autism Knowledge Quiz scores compared to those in the treatment-as-usual group. Autistic adolescents in the combined group also demonstrated a decrease in treatment-related stigma and an improvement in general mental health... | PMC10485995 | |
Conclusions | autistic, autistic adolescents | The ACAT program could be an effective treatment modality to increase the understanding of autistic attributes among both autistic adolescents and their parents/guardians. The ACAT program positively affects self-understanding, reduces treatment stigma, and stabilizes behavioral issues for autistic adolescents as a par... | PMC10485995 | |
Trial registration | : The study was registered in UMIN (UMIN000029851, 06/01/2018). | PMC10485995 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12888-023-05075-2. | PMC10485995 | ||
Keywords | PMC10485995 | |||
Background | PMC10485995 | |||
Autistic people and their mental health | Autistic | Autistic people demonstrate focused interests, sensitivity to sensory stimulation, and, as compared with the general population, differences in social communication and interaction [ | PMC10485995 | |
Psychological interventions for improving autistic individuals’ mental health | autistic, comorbid psychiatric disorders | Various interventions are used to treat social maladjustment and comorbid psychiatric disorders in autistic individuals. For example, psychotherapy, such as cognitive-behavioral therapy (CBT) and social skills training, can be administered to improve coping skills and environmental adjustment [ | PMC10485995 | |
Potential of psychological interventions to enhance autistic self-perception | autistic, ’, autism | Stigma against autism among parents/guardians may prevent autistic adolescents from receiving reasonable accommodations, which in turn, may increase their psychological burden. Destigmatizing the attitudes of parents/guardians is important to lower autistic individuals’ treatment stigma as parents/guardians can help ch... | PMC10485995 | |
Psychoeducation program to improve self-understanding of autistic traits | autistic traits, Autism | The Psychoeducation Group for Autism Spectrum Understanding and Support (PEGASUS) in the UK is one of the few evidence-based, structured family psychoeducation programs for autistic traits worldwide [ | PMC10485995 | |
Development of a new program on awareness and coping strategies for autistic traits using CBT | autistic traits, anxiety, Autism, autistic, depression | CBT is an evidence-based treatment for children, adolescents, and adults who have mental health issues such as depression and anxiety. It can be modified and applied to treat mental health issues in autistic children [
Similarities and differences between the PEGASUS and ACAT programIncreasing the recipient’s awareness... | PMC10485995 | |
Methods | This study was designed as a prospective, randomized, and assessor-blinded endpoint trial with two parallel intervention groups—COMB and TAU—consisting of a six-week intervention for both groups conducted as a multisite study.We evaluated outcomes at pre-intervention (0 weeks), post-intervention (6 weeks), and follow-u... | PMC10485995 | ||
Randomization | MH, autistic traits | Participants were allocated to either the intervention group (ACAT + TAU) or control group (TAU + waiting list to intervention) in a 1:1 ratio using the minimization method, based on gender (boy, girl, or other) and awareness of their autistic traits by the AKQ-Child (AKQ-C) (total score more or less than 2.4) at basel... | PMC10485995 | |
Participants | Autism, degenerative physical disorder, psychiatric, autistic, autism | DISORDERS, DISORDERS | The adolescents and parents/guardians provided written and verbal informed consent using the form and protocol approved by the Chiba University Clinical Research Ethical Review Committee. The inclusion criteria for adolescents were: (1) diagnosed with autism by their general practitioners using the Diagnostic and Stati... | PMC10485995 |
Sample size | In a previous study by Gordon et al. [ | PMC10485995 | ||
Intervention groups | PMC10485995 | |||
COMB group | autistic traits, autistic traits.οNaming the autistic traitsοTo, autistic traitsο Case formulations, autistic, cognitive and behavioral changes, adaptation?ο | SESSION | The ACAT program is an individual CBT intervention conducted once a week for 100 min each time [
Outline of ACAT components across the six-week programThemesο Session contentSession goalsο Required CBT techniquesLearn about your psychological assessment for autismο Sharing the results of psychological assessment testsο... | PMC10485995 |
TAU | The participants in the TAU group received no intervention from the research team. TAU involved regular 10-minute counseling sessions with a psychiatrist and, in some cases, medication and other coping therapies. | PMC10485995 | ||
Assessment and outcomes | PMC10485995 | |||
Participant characterization | PMC10485995 | |||
ADI-R | ADI-R | The ADI-R [ | PMC10485995 | |
ADOS-2 | The ADOS-2 [ | PMC10485995 | ||
WISC-IV | The WISC-IV [ | PMC10485995 | ||
M.I.N.I. | The MINI [ | PMC10485995 | ||
Adolescents’ outcome measures | PMC10485995 | |||
Primary outcome | autistic | AKQ-C. The English AKQ-C [The AKQ-C was administered to autistic adolescents at pre-intervention (week 0: before starting the first session), post-intervention (week 6: when they completed six sessions), and follow-up (week 10: one month after the completion of sessions). The change in AKQ-C scores from pre- to post-in... | PMC10485995 | |
Secondary outcomes | Depression | SECONDARY | As secondary outcomes for adolescents, self-report and parent/guardian-report questionnaires and semi-structured interviews for parents were used, and as secondary outcomes for parents/guardians, only self-report questionnaires were used to assess the efficacy of the interventions.Barriers to Access to Care Evaluation ... | PMC10485995 |
Secondary outcomes for parents/guardians | PMC10485995 | |||
AKQ-P | Like the AKQ-C [ | PMC10485995 | ||
BACE-3 | Similar to the assessment of adolescents, the BACE-3 was administered to their parents/guardians at three time points: pre-intervention, post-intervention, and follow-up. | PMC10485995 | ||
General health questionnaire | The General Health Questionnaire 12 (GHQ-12) [ | PMC10485995 | ||
Parenting resilience elements questionnaire | The Parenting Resilience Elements Questionnaire (PREQ) [ | PMC10485995 | ||
Other measures | Adherence to the ACAT manual and CBT were measured using the Revised Cognitive Therapy Scale (CTS-R) [ | PMC10485995 | ||
Recruitment and participant flow | autism | RECRUITMENT | From March 2018 to August 2020, recruitment, treatment, and data collection were conducted in Chiba and Fukushima, Japan. Adolescent outpatients (10–17 years) had been diagnosed with autism using gold-standard instruments such as the ADOS-2 and ADI-R. Their parents/guardians were informed about the intervention in the ... | PMC10485995 |
Statistical analyses | All statistical analyses were performed as pre-registered [ | PMC10485995 | ||
Results | autism spectrum disorder, learning disorder, attention-deficit/hyperactivity disorder | The demographic information for participants and parents/guardians in each group is provided in Table
Characteristics of the participantsADHD, attention-deficit/hyperactivity disorder; ASD, autism spectrum disorder; LD, learning disorder.Of the guardians participating in this study, 44 were mothers and one was a fathe... | PMC10485995 | |
Adherence to the ACAT manual and CBT | All ACAT activities were performed according to the manual [ | PMC10485995 | ||
Baseline characteristics | Depression, Autism | The demographic characteristics of the COMB and TAU groups are summarized in Tables 3 and 4. There were no significant differences in demographic characteristics at baseline, except for the participants’ age of consent (COMB: 12.8 years, TAU: 14.1 years,
Outcomes at baseline, post-intervention, and follow-up1.51(0.6(-... | PMC10485995 | |
Primary outcome | PMC10485995 | |||
Adolescents’ self-awareness of their autistic traits | autistic, autistic traits | The primary outcome was self-awareness of autistic traits in autistic adolescents measured by the AKQ-C. The primary interest was to examine if there was a change in the AKQ-C score from pre- to post-intervention for the COMB group compared with the TAU group. After the intervention, comparing the two groups, the effec... | PMC10485995 | |
Secondary outcomes | PMC10485995 | |||
Awareness of children’s autistic traits among parents and guardians | The COMB group had a large effect size (d = 0.99), with scores increasing from 3.8 (SD = 1.7) at week 0 to 6.4 (SD = 3.0) at week 6. The COMB group also had a greater increase in AKQ-P scores than the TAU group. | PMC10485995 | ||
Treatment stigma in autistic adolescents | We did not observe a change in treatment stigma in adolescents; the average score was 24.1 (SD = 10.6) at week 0 and 13.3 (SD = 8.7) at week 6. There were no differences in the degree of change in BACE-3 scores in the COMB group from week 0 to week 6 (d = -0.46, | PMC10485995 | ||
Treatment stigma in parents/guardians | We did not observe a change in scores from 20.3 (SD = 11.8) at week 0 to 20.1 (SD = 11.8) at week 6. | PMC10485995 | ||
General mental health, depression, and social adaptation in adolescents | There were differences between the COMB and TAU groups regarding the degree of change in general mental health; the average SDQ score in the COMB group reduced from 20 (SD = 4.7) at week 0 to 17 (SD = 5.8) at week 6. The COMB group showed a greater decrease in SDQ scores compared to the TAU group ( | PMC10485995 | ||
Mental health, adaptive skills, and attitudes toward children among parents/guardians | SD | We did not observe a change in parents’ resilience; the average PREQ score was 83.4 (SD = 10.5) at week 0 and 80.3 (SD = 13.8) at week 6. The same was the case with the GHQ-12; we did not observe a change in average scores from 16.4 (5.2) at week 0 to 11.5 (5.2) at week 6 in the COMB group. | PMC10485995 | |
Discussion | autistic, depression, autistic traits, ’ adaptive behavior | The objectives of this study were to evaluate the effectiveness of the ACAT intervention, developed to improve awareness of autistic traits among adolescents and parents/guardians. This would reduce treatment stigma and improve adolescents’ coping skills and social adaptation. We hypothesized that: (1) adolescents and ... | PMC10485995 | |
Improved awareness regarding autistic traits in adolescents | autistic, autistic traits | The improvement in adolescents’ self-awareness regarding their autistic traits and understanding of their children’s autistic traits among parents/guardians was significantly greater in those who participated in the ACAT program than in those who received TAU. This suggests that the ACAT was effective in helping autist... | PMC10485995 | |
Reduced treatment stigma in adolescents | autistic, autistic traits, Autism | Treatment stigma was reduced in adolescents in both the COMB and TAU groups. Autism diagnosis may be useful if those who receive it have adequate knowledge and self-understanding of autistic traits, which could improve access to services, help formulation of autistic identity, and guide future planning. However, stigma... | PMC10485995 | |
Improvements in general mental health among autistic adolescents | autistic, depression, depressive symptoms | Based on the SDQ scores, in the COMB group, there were improvements in adolescents’ general mental health, but this was not the case with the TAU group. Furthermore, based on the Vineland-II, the social adjustment did not significantly improve in autistic adolescents, but the effect size was moderate (d = 0.60). These ... | PMC10485995 | |
Improved awareness of autistic traits in parents/guardians | autistic, autistic traits |
The increase in awareness of their children’s autistic traits among parents/guardians (AKQ-P) between week 0 and week 6 was significantly higher in the COMB group than in the TAU group. This indicates that the ACAT program can help parents/guardians understand and recognize their children’s autistic traits. However, i... | PMC10485995 | |
Limitations | autistic, autistic traits, psychiatric, autism | DISORDER, DISORDERS | This study has several limitations. First, as the sample size was small and diagnostic timing was not considered, we did not control for the presence of other mental disorders. Second, when comparing the ACAT program and TAU, it was unclear which aspects of the former contributed to changes in self-awareness of autisti... | PMC10485995 |
Conclusions | autistic traits, anxiety, ’ autistic traits, social behaviors, autistic, depression |
The ACAT program is effective in improving autistic adolescents’ self-awareness of autistic traits, and it can help parents/guardians understand their adolescents’ autistic traits. It also helps improve general mental health and reduce treatment stigma in autistic adolescents. Although we did not observe significant e... | PMC10485995 | |
Electronic supplementary material | autistic, Autistic Traits | Below is the link to the electronic supplementary material.
Supplementary Material 1: Supplementary materials for Awareness and Care for my Autistic Traits (ACAT) program for autistic adolescents: a multicenter randomized controlled trial | PMC10485995 | |
Acknowledgements | Our deep appreciation is extended to Kanae Osumi at the Department of Psychiatry, Hamamatsu University School of Medicine, for their immense contribution to this investigation. | PMC10485995 | ||
Authors’ contributions | FO, study concept and design; WM, guidance in research design; MS, drafting of the manuscript; MH, study therapist; AT, drafting of the manuscript; TO, critical revision of the manuscript; YH, clinical revision of the manuscript; CS, clinical revision of the manuscript; SG, study therapist; YN, study therapist; YO, sta... | PMC10485995 | ||
Funding | This work was supported by the Association of Japanese Clinical Psychology (Grant Number 2017 S-1). The funder had no role in the design of the study or collection, analysis, or interpretation of data or in writing the manuscript. | PMC10485995 | ||
Data availability | The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request. | PMC10485995 | ||
Declarations | PMC10485995 | |||
Ethics approval and consent to participate | This trial was approved by the Chiba University Clinical Research Ethical Review Committee (CRB3180015, No. G29027). The participating patients and parents provided written and verbal informed consent using the form and protocol approved by the Chiba University Clinical Research Ethical Review Committee. Following a ve... | PMC10485995 | ||
Consent for publication | Not applicable. | PMC10485995 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10485995 | ||
References | PMC10485995 | |||
Background | DISEASES, ADVERSE EFFECT | To evaluate the effect of transvaginal natural orifice transluminal endoscopic surgery (vNOTES) on female sexual function. Methods: The trial was registered at the Chinese Clinical Trial Registry (ChiCTR2100050887, 07/09/2021). In this prospective cohort study, we prospectively analyzed the data of the female sexual fu... | PMC10398902 | |
Keywords | PMC10398902 | |||
Background | DISEASE, DISEASES, ADVERSE EFFECTS, CAVITY, VAGINA, URETHRA | Natural orifice transluminal endoscopic surgery (NOTES) emerges as a significant innovation in the field of minimally invasive surgery during the last decade, which utilizes the natural orifices of the body surface, such as the mouth, anus, vagina, or urethra, to access the peritoneal cavity [The clinical feasibility o... | PMC10398902 | |
Methods | This study was approved by the Ethics Committee of Chengdu Women’s and Children’s Central Hospital (No: [2020]164). The trial was registered at the Chinese Clinical Trial Registry (ChiCTR2100050887). All participants provided written informed consent after enrollment. | PMC10398902 | ||
Inclusion criteria | GYNECOLOGICAL DISEASE | 1. From January 1, 2021 to December 31, 2021, nonporous women of reproductive age undergoing laparoscopic surgery for “benign gynecological diseases” in Chengdu Women’s and Children’s Central Hospital; 2. 18–40 years old; 3. Sexually active women who have fixed sex partners, regular sex. | PMC10398902 | |
Exclusion criteria | malignant tumors | MALIGNANT TUMORS | 1. Patients with a previous history of vaginal or cervical surgery; 2. Patients undergoing hysterectomy or subtotal hysterectomy in this surgery; 3. Patients included in the vNOTES group underwent a conversion from vNOTES surgery to trans-abdominal laparoscopy; 4. malignant tumors suggested by postoperative pathologica... | PMC10398902 |
Assignment of the patients | The assignment of the patients is determined by combining the doctor’s assessment and the patient’s wishes. All patients were assigned to the vNOTES group or control group according to different surgical approaches. The control group included traditional laparoscopic surgery and transumbilical laparoendoscopic single-s... | PMC10398902 | ||
Questionnaire | tubal pregnancy fenestration, adenomyoma of uterus | ADENOMYOMA OF UTERUS | The Female Sexual Function Index (FSFI) is a commonly used sexual functioning questionnaire developed by Rosen et al. [
Baseline characteristicsEducation level[n(%)]Bachelor degree or above43(66.15)Bachelor degree or above34(52.31)Below bachelor degree22(33.85)Below bachelor degree31(47.69)surgical type[n(%)]Ovarian cy... | PMC10398902 |
Sample size | SECONDARY | The two-sided test was adopted, setting the level of significance alpha at 5% (α = 0.05) and the power of the sample at 80% (β = 0.20). According to the pre-test results, the FSFI scores of the exposure group and control group were 20.87 ± 6.87 and 23.75 ± 5.50 respectively. Considering a dropout rate of 10%, the estim... | PMC10398902 | |
Statistical analysis | SPSS 20.0 statistical software was used for statistical analysis. The measurement data were expressed as mean ± standard deviation such as age, body mass index and FSFI score. The data conforming to normal distribution and homogeneity of variance adopted the | PMC10398902 | ||
Results | A total of 130 patients were included in this study including 65 in the vNOTES group and 65 in the control group. Among them, 3 patients in the vNOTES group and 2 patients in the control group dropped out during the 3 months of follow-up due to incorrect phone numbers. Moreover, 1 patient in the vNOTES group was droppe... | PMC10398902 | ||
Discussion | sexual pain, vaginal innervation | VAGINA | This study was designed to assess the effect of vNOTES on female sexual function. Our results revealed no significant difference in sexual function before and after surgery in patients undergoing vNOTES, and also no significant difference in sexual function after surgery between patients receiving vNOTES and transabdom... | PMC10398902 |
Acknowledgements | Not applicable. | PMC10398902 | ||
Authors’ contributions | GZL | XDY: study concept, data verification, literature review, manuscript writing, and manuscript revision. HL (Lu Huang): study concept, data verification, literature review, manuscript writing, and manuscript revision. HL (Li He): data verification, literature review, and manuscript writing. LYH: preparation of data for s... | PMC10398902 | |
Funding | This work was supported by grants from Technological Innovation Research and Development Project of Chengdu Science and Technology Management (2021-YF05-00627-SN), the Medical Research Foundation of Chengdu Health Commission (NO. 2021215), and the Chengdu High-level Key Clinical Specialty Construction Project. | PMC10398902 | ||
Data Availability | The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy restricions. | PMC10398902 | ||
Declarations | PMC10398902 | |||
Ethics approval and consent to participate | This study was approved by the Ethics Committee of Chengdu Women’s and Children’s Central Hospital (No: [2020]164). All participants provided written informed consent after enrollment. All methods were carried out in accordance with relevant institutional guidelines and regulations. | PMC10398902 | ||
Consent for publication | Not applicable. | PMC10398902 | ||
Competing interests | The authors declare no competing interests. | PMC10398902 |
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