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Declarations | PMC10201743 | |||
Ethics approval and consent to participate | The study was approved by the Ethics Committee of China (ChiECRCT20200137) on June 12, 2020, and registered at ClinicalTrials.gov (NCT04421976). Participants were included after obtaining written informed consent. All methods were carried out in accordance with relevant guidelines and regulations(declaration of helsink... | PMC10201743 | ||
Consent for publication | Not applicable. | PMC10201743 | ||
Competing interests | Dr. Zhanqi Zhao receives a consulting fee from Dräger Medical. The remaining authors have no conflicts of interest to declare. | PMC10201743 | ||
Abbreviations | respiratory distress | Postoperative pulmonary complicationsDriving pressureElectrical impedance tomographyGlobal inhomogeneityLung ultrasonography scoresIntracranial pressurePositive end-expiratory pressureThe partial pressure of arterial oxygen to the fraction of inspired oxygenAcute respiratory distress syndromeTidal volumeComputed tomogr... | PMC10201743 | |
References | PMC10201743 | |||
Background | HF, fracture, dementia, Cognitive impairment, depressive disorders | Hip fracture (HF) is a significant cause of mortality among older people. Almost half of the patients with HF have dementia, which increases the mortality risk further. Cognitive impairment is associated with depressive disorders (DDs) and both dementia and DDs are independent risk factors for poor outcome after HF. Ho... | PMC9996856 | |
Aims | dementia, depressive disorders | To investigate whether dementia with depressive disorders (DDwD) affects the mortality risk at 12, 24, and 36 months after HF among older people. | PMC9996856 | |
Methods | Patients with acute HF ( | PMC9996856 | ||
Results | comorbidity, fracture, dementia, depressive disorders | In analyses adjusted for age, sex, comorbidity, pre-fracture walking ability, and fracture type, patients with DDwD had increased mortality risks at 12 [odds ratio (OR) 4.67, 95% confidence interval (CI) 1.75–12.51], 24 (OR 3.61, 95% CI 1.71–7.60), and 36 (OR 4.53, 95% CI 2.24–9.14) months. Similar results were obtaine... | PMC9996856 | |
Conclusion | depressive disorders | DDwD is an important risk factor for increased mortality at 12, 24, and 36 months after HF among older people. Routinely assessments after HF for cognitive- and depressive disorders could identify patients at risk for increased mortality, and enable early interventions. | PMC9996856 | |
Trial registration | RCT2: International Standard Randomized Controlled Trial Number Register, trial registration number: ISRCTN15738119. | PMC9996856 | ||
Keywords | Open access funding provided by Umea University. | PMC9996856 | ||
Introduction | fracture, HF, dementia | The hip fracture (HF) incidence increases with age, and HF is a significant cause of mortality among older (aged < 60 years) people [Almost half of patients sustaining HFs have dementia [DDs and dementia are independent predictors of poor outcomes and increased mortality risk after HF [ | PMC9996856 | |
Method | PMC9996856 | |||
Study design and participants | femoral-neck fractures | MAY, SECONDARY | Data used in this secondary analysis of 404 patients with acute HFs were from two randomized controlled trials (RCT1 and RCT2). Both RCT were performed in the orthopedic- and the geriatric departments of Umeå University Hospital, Sweden. RCT1 included 199 patients with femoral-neck fractures enrolled in May 2000-Decemb... | PMC9996856 |
Randomized controlled trials | RECRUITMENT, POSTOPERATIVE COMPLICATIONS | Participants in both RCTs were randomized consecutively to intervention and control groups. In RCT1, participants in the intervention group received postoperative care according to a multifactorial rehabilitation program in a specialist orthopedic geriatric unit. Multidisciplinary teams performed comprehensive geriatri... | PMC9996856 | |
Data collection | death | At baseline, research assistants (nurses, physiotherapists, and occupational therapists) collected medical, functional, and social data from the patients, their relatives, and/or medical charts. In RCT1 and RCT 2, assessments were performed at 3–5 days postoperatively. Dates of death were collected from medical records... | PMC9996856 | |
Outcome measurements | Depression, depressive symptoms | COMPLICATIONS | The outcome was 12-, 24- and 36-month mortality following HF surgery. DDs diagnoses were based on current antidepressant treatment and Geriatric Depression Scale (GDS-15) scores (scores ≥ 5 indicate significant depressive symptoms) [At the end of the RCTs, a consultant geriatrician (YG), blinded to group allocation and... | PMC9996856 |
Statistics | Baseline characteristics were compared between surviving and deceased participants at 36 months after HF. Pearson’s chi-square test and Fisher’s exact test were used to analyze categorical variables. Normally and non-normally distributed data were compared between groups using the independent-sample t and Mann–Whitney ... | PMC9996856 | ||
Results | PMC9996856 | |||
Discussion | fracture, dementia | DISORDERS | The main finding in our study was that DDwD were significantly associated with increased 12-, 24- and 36-month mortality risk following HF. In addition, patients with dementia, without DDs, also had increased mortality risk at all three follow ups.The mortality risk is the highest the first year after hip fracture, whi... | PMC9996856 |
Conclusion | depressive disorders | This study showed that patients with baseline DDwD have increased mortality risks at 12, 24, and 36 months after HF. Routinely assessments after HF for cognitive- and depressive disorders could identify patients at risk for increased mortality, and enable early interventions.
| PMC9996856 | |
Acknowledgements | The authors thank the patients and staff in the orthopedic and geriatric departments at Umeå University Hospital, especially Anna Rehnmark, who helped with data merging. We also thank Eva Elinge, Monica Långström‐Berggren, Nina Lindelöf, Åsa Karlsson, and Michael Stenvall for helping with data collection, and Undis Eng... | PMC9996856 | ||
Authors’ contributions | dementia | COMPLICATIONS | EO analyzed, interpreted the patient data and was a major contributor in writing the manuscript. YG analyzed all assessments, documentations, registered diagnosis and complications from patients’ medical records. The same consultant analyzed all assessment data and documentation to determine whether participants fulfil... | PMC9996856 |
Funding | ALF, Dementia | Open access funding provided by Umea University. This study was supported by the Vardal Foundation, Joint Committee of the Northern Health Region of Sweden (Visare Norr), ALF, JC Kempe Memorial Foundation, Foundation of the Medical Faculty of Umeå University, County Council of Västerbotten (“Dagmar,” “FoU,” and “Äldrec... | PMC9996856 | |
Availability of data and materials | The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request. | PMC9996856 | ||
Declarations | PMC9996856 | |||
Ethics approval and consent to participate | Participants in both RCTs received written and oral information, and they or their next of kin was consulted to provide written informed consent on their behalf. Participants and/or next of kin were informed that they could withdraw at any time with no repercussion. The RCTs were approved by the Regional Ethical Review... | PMC9996856 | ||
Consent for publication | Not applicable. | PMC9996856 | ||
Competing interests | The authors declare that they have no competing interests. | PMC9996856 | ||
References | PMC9996856 | |||
Purpose | The primary aim of this study was to examine whether a glycine-rich collagen peptides (CP) supplement could enhance sleep quality in physically active men with self-reported sleep complaints. | PMC10799148 | ||
Methods | In a randomized, crossover design, 13 athletic males (age: 24 ± 4 years; training volume; 7 ± 3 h·wk | PMC10799148 | ||
Results | fatigue | INFLAMMATION | Polysomnography showed less awakenings with CP than CON (21.3 ± 9.7 vs. 29.3 ± 13.8 counts, respectively; P = 0.028). The 7-day average for subjective awakenings were less with CP vs. CON (1.3 ± 1.5 vs. 1.9 ± 0.6 counts, respectively; P = 0.023). The proportion of correct responses on the baseline Stroop cognitive test... | PMC10799148 |
Conclusion | CP supplementation did not influence sleep quantity, latency, or efficiency, but reduced awakenings and improved cognitive function in physically active males with sleep complaints. | PMC10799148 | ||
Keywords | PMC10799148 | |||
Introduction | daytime impairment, sleep disorders, sleep disturbance, Insomnia | Insomnia, defined by nocturnal sleep disturbance (e.g., difficulty falling asleep and staying asleep) and functional daytime impairment, is one of the most common sleep disorders [As several nutrients interact with neurotransmitters that help regulate the sleep–wake cycle, there is a growing interest in dietary strateg... | PMC10799148 | |
Methods | PMC10799148 | |||
Sample size estimation | Our sample size was determined from an a priori power analysis (G*power 3.1.9.2, Microsoft Windows [ | PMC10799148 | ||
Experimental design | sleepiness, fatigue | Prior to the supplementation trials, participants completed a familiarisation trial, in which they had their physical activity and sleep monitored for 7 days and nights in their home. This was to characterise exercise and sleep schedules (i.e., bedtimes and wake times) for the supplementation trials, and to familiarise... | PMC10799148 | |
Supplementation | Participants consumed 15 g/day of CP derived from bovine hide or an inert, taste matched, CON as a 200 ml liquid bolus, without food, ~ 1 h before their scheduled bedtime (as recorded in the familiarisation trial) for 7 days. A 15 g CP dose was selected as it contains ~ 3.5 g of glycine, an amount shown to enhance slee... | PMC10799148 | ||
Athens insomnia scale and morning-eveningness questionnaire | AIS | The AIS is an eight-item survey that assesses sleep difficulty in the past month; a score of ≥ 6 is indicative of poor sleep [ | PMC10799148 | |
Sleep and training diaries, and actigraphy | Participants used sleep diaries to self-report their time in bed, bedtime, SOL, number of awakenings, length of awakenings, wake up time, and get up time during the trials. Any day-time naps were also recorded. Training diaries were used to record the intensity and volume of scheduled exercise completed each day. Inten... | PMC10799148 | ||
Subjective surveys | Subjective sleep quality was recorded with a 7-point Likert scale, where 1 = extremely poor and 7 = extremely good [ | PMC10799148 | ||
Cognitive function | Participants completed a series of cognitive tests that took approximately 10 min on a laptop. All tests were preceded by 3–5 practice trials. The first test was simple reaction time (RT), where participants were instructed to press the spacebar when a green circle appeared on a blank screen. The second test was choice... | PMC10799148 | ||
Dietary control | Participants recorded their dietary intake on day 7 of the familiarisation trial and were instructed to replicate this intake on the two supplementation trials. On this day they were instructed to limit their intake of protein-rich foods (a list was provided), avoid consuming any caffeine after 11:00, and attend the la... | PMC10799148 | ||
Blood and urine samples | BLOOD | Blood and urine samples were collected the evening of day 7 and the morning of day 8. Urine samples were collected in a plastic container; venous blood samples were obtained via venipuncture into 1 × 10 ml vacutainer for serum and 1 × 10 ml vacutainer coated with EDTA to obtain plasma. The EDTA vacutainer was immediate... | PMC10799148 | |
Measurements of serum cortisol and urine normetanephrine by LC–MS/MS | SEPARATION, POSITIVE | Serum cortisol and urine normetanephrine were measured using Liquid chromatography tandem mass spectrometry (LC–MS/MS) methods by a Waters Acquity I-class UPLC system coupled to the Xevo TQ-XS tandem mass spectrometer (Waters Corp., Milford, MA, USA) operated in positive electrospray mode. Serum cortisol was extracted ... | PMC10799148 | |
Serum C-Reactive Protein high sensitive (hs-CRP) | Serum hs-CRP was measured using a particle-enhanced immunoturbidimetric assay analysed on the COBAS® C501 analyser (Roche, Burgess Hill, UK). The inter-assay CV was < 2.6% across the assay working range 1.43–190 nmol/L. | PMC10799148 | ||
Data analysis | fatigue | Data analysis was performed with SPSS (IBM SPSS Statistics for Windows, Version 27.0. Armonk, NY: IBM Corp). Normality was assessed by visually inspecting histograms and skewness and kurtosis and homogeneity of variance for linear mixed models by plotting the residuals against the predicted values. Variables collected ... | PMC10799148 | |
Results | Three participants were excluded at screening because they scored < 6 on the AIS; one participant dropped out after contracting COVID-19. In total, 13 volunteers completed the full study. | PMC10799148 | ||
Polysomnography | For intrarater ICC values, apart from N3 (%) which showed moderate reliability (0.61–0.64), all other variables showed good reliability (≥ 0.83). For interrater ICC values, all variables had good reliability (≥ 0.86), apart from N2 (%), which showed moderate reliability (0.58).Table | PMC10799148 | ||
Subjective sleep diary data | Subjective SOL did not differ between CP (19.9 ± 6.6 min) and CON (19.5 ± 14.6 min) (P = 0.972; | PMC10799148 | ||
Actigraphy sleep data | Sleep variables derived from actigraphs are presented in Table Sleep variables for the control and collagen peptides trials, as measured by wristwatch actigraphyData used for analysis is average of 7 nights. 95% CI, 95 confidence interval for the difference in means. Effect size is Hedges | PMC10799148 | ||
Subjective sleep quality and fatigue | sleepiness, fatigue | Table Subjective sleep quality, sleepiness, and fatigue scales for the control and collagen peptides trialsAU = arbitrary units; KSS = 7-day average for Karolinska Sleepiness Scale; AM = recorded 30 min after waking; MID = recorded at 14:00; PM = recorded 1 h pre-beda = significantly lower than AM (P < 0.05)b = signifi... | PMC10799148 | |
Physical activity | Daily training load during the CON and CP trials was 419 ± 214 and 388 ± 269 AU, respectively; these were not significantly different (P = 0.578; | PMC10799148 | ||
Core temperature | Core temperature recordings were missing at random for 7/117 time-points in CON and CP. As shown in Fig. Changes in core temperature during the main trial night (night 7) in the control and collagen peptides (CP) conditions. FA, final awakening/lights on. a = significantly different to -60 min | PMC10799148 | ||
Discussion | SE, sleep complaints | The main findings of this study are that 7 days of CP supplementation; 1) reduced awakenings, as measured objectively by PSG, and subjectively via sleep diaries, and 2) improved cognitive performance, as measured by the Stroop test. This is the first study to show that CP supplementation may reduce sleep fragmentation ... | PMC10799148 | |
Funding | Funding was provided by Rousselot BV. | PMC10799148 | ||
Availability of data and material | Not available. | PMC10799148 | ||
Code availability | Not applicable. | PMC10799148 | ||
Declarations | PMC10799148 | |||
Conflict of interest | The funders supplied the supplements used in this study. Janne Prawitt and Nicolina Virgilio are employees of Rousselot BV. | PMC10799148 | ||
Ethical approval | All the study procedures were in accordance with the ethical standards of the institutional research ethics committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. | PMC10799148 | ||
References | PMC10799148 | |||
Purpose | We conducted this study, comparing the outcomes among Transverse Onlay Island Flap, inlay grafted incised plate and our previous records of tubularized incised plate urethroplasty (TIPU) in patients with narrow urethral plates, aiming to determine which method of repair provides a good outcome. | PMC10693502 | ||
Methods | hypospadias, distal primary hypospadias | This hybrid study included two datasets. The first from a prospective randomized study evaluating outcomes of two treatment modalities; Inlay graft and only flap for distal hypospadias with shallow urethral plate with 80 patients (40 patients in each group) included, the second based on our previous records of TIPU in ... | PMC10693502 | |
Results | The success rate in inlay graft urethroplasty group ( | PMC10693502 | ||
Conclusion | penile hypospadias | COMPLICATIONS | Inlay graft and onlay flap urethroplasty for repair of distal penile hypospadias with narrow urethral plate had higher success rate and fewer complications than traditional TIPU. Moreover, operative time was shorter in TIPU. | PMC10693502 |
Keywords | Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). | PMC10693502 | ||
Introduction | chordee, hypospadias, fibrosis, stenosis | FIBROSIS, STENOSIS | In 1994, Snodgrass reported the use of tubularized incised plate urethroplasty (TIPU) with a urethral plate incision that not only widened the plate but also provided a slit-like vertical neourethral meatus, the incised plate healing is still a matter of debate, some authors think that there is complete re-epithelizati... | PMC10693502 |
Patients and methods | chordee, primary distal penile hypospadias | PENIS | This hybrid study included two datasets. The first dataset was from a prospective randomised study carried out from January 2016 to March 2021 study included 80 patients; 40 patients in group I (grafted incised plate) and 40 patients in II group (onlay flap) who had primary distal penile hypospadias with a narrow ureth... | PMC10693502 |
Operative techniques | PENIS | All operations were performed by two authors. The operation began with a dorsal circumferential subcoronal incision, which was extended ventrally to 2 mm below the hypospadiac urethral meatus. Subsequently, the penis was degloved, and the urethral plate width was measured. The glanular wings were prepared. A deep midli... | PMC10693502 | |
Inlay graft [ | mucocutaneous | The graft was outlined, harvested, and defatted from the inner preputial skin; it was then placed over the incised urethral plate and fixed to its edges from the original meatus to the tip of the glans at the mucocutaneous junction with 7/0 Vicryl sutures. The graft was quilted to the underlying corpora in the incised ... | PMC10693502 | |
Onlay flap [ | A transverse inner preputial flap was outlined with a minimum width of 8 mm, and the length was adjusted according to the distance between the hypospadiac meatus and the tip of the glans. The flap was dissected with the dartos pedicle, rotated ventrally, and sutured to the urethral plate edges with 7/0 Vicryl sutures o... | PMC10693502 | ||
Tubularised incised plate urethroplasty as described by Snodgrass [ | fistula | DEHISCENCE, COMPLICATION, PENIS, MEATAL STENOSIS, COMPLICATIONS | A subcuticular closure of the neourethra was achieved with 7/0 Vicryl sutures over a urethral catheter. A second covering layer from the dorsal dartos was applied. Finally, glanular and skin closure was performed as previously described. Patients were discharged with an indwelling catheter measuring 6-8F, which was rem... | PMC10693502 |
Sample size calculation | COMPLICATION | Before the study, the number of patients required in each group was determined after a power calculation according to data obtained from previous studies. In those studies, the complication rate in group I was 8% [ | PMC10693502 | |
Statistical analysis | The data were analysed by Statistical Package for Social Sciences program (SPSS) software version 20. Descriptive statistics for numerical variables are presented as the mean and standard deviation, and those for qualitative variables are presented as numbers and percentages. One-way analysis of variance (ANOVA) was us... | PMC10693502 | ||
Results | hypospadias, dehiscence, meatal stenosis, fistula, glandular dehiscence, fistulas | MEATAL STENOSIS, DEHISCENCE, COMPLICATIONS, COMPLICATION | Of the 315 hypospadias cases at our institution during the study period, 80 met our inclusion criteria (Fig. Consort 2010 flow diagramPatients demographics and outcome in the three studied groupsOperative time (min.)RangeMean ± SD81–11298 ± 1476–11186 ± 2560–9371 ± 22The overall complication rate in the inlay graft ure... | PMC10693502 |
Discussion | hypospadias, Postoperative urinary fistulas, dehiscence, fistula, Tariq, fistulas | DEHISCENCE, COMPLICATIONS, COMPLICATION | TIPU repair for distal and mid-penile hypospadias has gained widespread acceptance because it is versatile, has a low complication rate, and reliably results in a vertically oriented meatus. Various factors affect the success rate of hypospadias repair, among which is the urethral plate [Tariq et al. concluded that the... | PMC10693502 |
Authors contributions | AFH | MMA: operative work, data collection, critical revision of the manuscript for scientific. AZA: operative work, data acquisition and critical revision of the manuscript for scientific. AHA: manuscript drafting. MFR: manuscript revision. MSM: conception and design. AFH: data acquisition, data analysis. MGSH: data collect... | PMC10693502 | |
Funding | Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). | PMC10693502 | ||
Declarations | PMC10693502 | |||
Conflict of interest | All authors declare no conflict of interest and no financial support. | PMC10693502 | ||
Ethical statement | This study was conducted in concordance with the Declaration of Helsinki 2013 and in accordance with our faculty ethical standards, and after obtaining informed consents. | PMC10693502 | ||
References | PMC10693502 | |||
1. Introduction | atherosclerotic cardiovascular diseases | CVD, ATHEROSCLEROTIC CARDIOVASCULAR DISEASE | Most atherosclerotic cardiovascular diseases can be prevented by modifying lifestyles, including unhealthy diets. Eggs contain important carotenoids that may impact cardiovascular risk. The lipid nature of eggs can improve the bioavailability of other carotenoids, such as Annatto (Most atherosclerotic cardiovascular di... | PMC9865189 |
2. Materials and Methods | This was a parallel randomized clinical trial with three intervention groups. One hundred and five ( | PMC9865189 | ||
2.1. Intervention | RECRUITMENT | The recruitment of the participants took place between October 2019 and December 2020. The volunteers underwent an initial washout period of 2 weeks in which they were asked to not consume eggs. After signing the informed consent document, biochemical tests were done to ensure that no exclusion criteria were present. S... | PMC9865189 | |
2.2. Blood Collection | BLOOD | Blood samples were collected from the antecubital vein using dried tubes after an overnight 12 h fast. After 30 min, the tubes were centrifuged at 450× | PMC9865189 | |
2.3. Anthropometric Measurements | Weight and height were measured using a stadiometer (SECA 216, seca S.A.S., Hamburg, Germany) and a scale (SECA 813, seca S.A.S., Hamburg, Germany). Then, BMI was calculated as kg/m | PMC9865189 | ||
2.4. Blood Lipid Profile, Glucose, and Liver Enzymes | TG | Total cholesterol (TC), HDL cholesterol (HDL-C), LDL cholesterol (LDL-C), triglycerides (TG), glucose, and liver enzymes (AST, aspartate aminotransferase; ALT, alanine aminotransferase) were measured via enzymatic colorimetric methods using an automatic analyzer (Siemens | PMC9865189 | |
2.5. Lipoproteins and Apolipoproteins | Nuclear magnetic resonance was used for the measurement of apolipoprotein (Apo) B, Apo A1 concentration, and the total number, size, and concentration of lipoprotein particles. The analysis was performed by Labcorp© (Laboratory Corporation of America Holdings, Burlington, NC, USA). | PMC9865189 | ||
2.6. Diet Analysis | Diet was evaluated using a semiquantitative food frequency questionnaire (FFQ) at the beginning and last week of the intervention. Total energy (Kcal) and macronutrient intake (g) were estimated using a Colombian food database [ | PMC9865189 | ||
2.7. Statistical Analysis | PBC | A per-protocol analysis was performed with participants who demonstrated at least 80% adherence to the study. To describe the study population, a univariate analysis was performed with percentages and Pearson’s chi-squared test. For frequencies less than 5, Fisher’s Exact Test was applied. In addition, a group mean ana... | PMC9865189 | |
3. Results | One hundred and forty-four (According to the randomization method, the proportion of women was the same in the three groups. Likewise, there were no differences between groups in age, BMI, and sociodemographic variables (The results obtained for the traditional cardiovascular risk variables, from blood lipid profiles a... | PMC9865189 | ||
4. Discussion | CV disease, heart disease, cardiovascular disease, CVD | CARDIOVASCULAR DISEASE, HEART DISEASE, CVD, INCREASED TRIGLYCERIDES, ATHEROGENIC DYSLIPIDEMIA | The main findings in this study were that, compared to egg whites, two eggs per day, alone or in combination with Annatto, resulted in similar concentrations of plasma LDL cholesterol, triglycerides, and apolipoprotein B, important biomarkers for cardiovascular disease risk [In this study, a higher percentage of women ... | PMC9865189 |
5. Conclusions | inflammation | CVD, INFLAMMATION, OXIDATIVE STRESS | Eggs cannot be seen only as a source of cholesterol. Eggs also provide minerals, vitamins, antioxidants, and, importantly, a source of good-quality protein. Therefore, eggs represent an excellent option to be included as part of a balanced and healthy diet without increasing risk factors for CVD in our population, as w... | PMC9865189 |
6. Limitations | BLIND | Although it was possible to control the study for different factors such as age, sex, and BMI, it is important to consider that it was not possible to blind the intervention groups, and this could have implications for biases. Especially for the control group, the only natural food coloring available in the market was ... | PMC9865189 |
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