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861 | Repair of salivary fistulae after laryngectomy.
A new surgical technique is described for the repair of salivary fistulae.
It has been used in three patients.
The fistulae occurred after laryngectomy and had been unsuccessfully treated with local and regional flaps.
The principle of the technique is to use a bipedi... | 6 |
2,993 | Lung sound nomenclature survey.
We report the terms used by 223 pulmonary physicians and 54 physicians in other specialties to describe eight recorded examples of lung sounds.
The participants listened to the lung sounds at the 1988 American College of Chest Physicians annual convention and wrote "free form" answers.... | 22 |
2,678 | Low level atmospheric sulfur dioxide pollution and childhood asthma.
Quarterly analysis (1983-1987) of childhood asthma in Hong Kong from 13,620 hospitalization episodes in relation to levels of pollutants (SO2, NO2, NO, O3, TSP, and RSP) revealed a seasonal pattern of attack rates that correlates inversely with expos... | 19 |
1,045 | Dementia: what to do.
Dementia is a syndrome of acquired intellectual deterioration that interferes with personal or social functioning.
Diagnosis requires historical information from the family and the mental status evaluation of orientation, recent memory, comprehension, calculation, and abstraction.
Most dementia... | 9 |
3,305 | Profound digital collagen atrophy: a new cutaneous presentation of adrenal-dependent Cushing's syndrome.
A 59-year-old Caucasian housewife presented with a 2-year history of marked loss of tissue substance from the finger and toe pulps and the heel pads.
There was no clinical evidence or history of urticaria or other... | 22 |
1,686 | Systolic hypertension in the elderly: reasons not to treat.
Isolated systolic hypertension in the elderly is associated with increased morbidity and mortality.
Accurate measurement of blood pressure in older patients is difficult.
Therapy can be associated with various complications, and the special problems of the ... | 13 |
2,674 | Seroprevalence of HIV infection in the general population of the Cote d'Ivoire, West Africa.
A seroepidemiological survey to determine the prevalence of human immunodeficiency virus (HIV) infection in the general population of the Ivory Coast was carried out in February 1989.
Sera were collected from subjects between... | 19 |
561 | Glucocorticoids locally disrupt an array of positioned nucleosomes on the rat tyrosine aminotransferase promoter in hepatoma cells.
Transcriptional activation by steroid hormones is often associated with the appearance of a DNase I hypersensitive site resulting from a local alteration of the nucleoprotein structure of... | 3 |
2,162 | Total and differential leukocyte counts in clinically well children. Information or misinformation?
To determine whether the total and differential leukocyte count is of value as a case-finding test, we applied the evaluation criteria developed by the US Preventive Services Task Force.
The criteria comprise review of... | 14 |
2,446 | Molecular mapping of the mouse db mutation.
Diabetes (db) is an autosomal recessive mutation located in the midportion of mouse chromosome 4 that results in profound obesity with hyperphagia, increased metabolic efficiency, and insulin resistance.
To clone this gene and generate a molecular map of the region around t... | 17 |
453 | A phosphatase activity present in peripheral blood myeloid cells of chronic myelogenous leukemia patients but not normal individuals alters nuclear protein binding to transcriptional enhancers of interferon-inducible genes.
Cytoplasmic protein from peripheral blood myeloid cells of chronic myelogenous leukemia (CML) p... | 3 |
1,725 | Effect of captopril injection in patients with moderate to severe hypertension.
The effect of intravenous captopril was studied in 24 white patients who had moderate to severe hypertension.
Patients received incremental doses of 1 to 10 mg delivered at 10 min intervals over 50 to 80 min.
Blood pressure (BP) was lowe... | 13 |
646 | A controlled trial of intravenous immunoglobulin G in chronic fatigue syndrome
PURPOSE: Currently, there is no established therapy for chronic fatigue syndrome (CFS), a recently defined illness that has been associated with a variety of immunologic abnormalities.
Based on the hypothesis that a chronic viral infectio... | 4 |
1,479 | Effect of serum from patients with minimal to mild endometriosis on mouse embryo development in vitro.
Two-cell mouse embryos were cultured at 37 degrees C in 5% CO2, 95% air with a 7.5% serum supplement from patients with minimal to mild endometriosis, (group I, n = 31), tubal factor (group II, n = 33), male factor (... | 12 |
2,543 | A human XY female with a frame shift mutation in the candidate testis-determining gene SRY.
The primary decision about male or female sexual development of the human embryo depends on the presence of the Y chromosome, more specifically on a gene on the Y chromosome encoding a testis-determining factor, TDF.
The human... | 18 |
1,815 | Early 24-hour blood pressure elevation in normotensive subjects with parental hypertension
Subjects with a family history of parental hypertension are reported to have a slightly higher office blood pressure in the prehypertensive stage.
Whether this reflects a hyperreactivity to blood pressure measurement or a more... | 13 |
1,178 | Cerebral blood flow velocities in the anterior cerebral arteries and basilar artery in hydrocephalus before and after treatment.
We studied Pourcelot's index (PI), which shows cerebral vascular resistance, in the anterior cerebral arteries and basilar artery, and the PI ratio (Pourcelot's index in the anterior cerebra... | 9 |
2,980 | Tissue expansion of the head and neck. Indications, technique, and complications.
Tissue expansion is indicated in the reconstruction of various defects of the head and neck in instances where there is inadequate adjacent tissue to allow either primary closure of the defect or repair with a local flap.
It may also be... | 22 |
3,121 | Comparison of ventricular arrhythmia induction with use of an indwelling electrode catheter and a newly inserted catheter.
Two methods of serial electrophysiologic testing are in widespread use.
Most commonly, the electrode catheter is removed after each study and a new catheter reinserted through the femoral vein fo... | 22 |
2,840 | Poly(L-lactide) implants in repair of defects of the orbital floor: an animal study.
Because of the life-long presence of alloplastic, nonresorbable orbital floor implants and the complications of their use mentioned in literature, the use of a resorbable material appears to be preferable in the repair of orbital floo... | 20 |
2,157 | Viral infections in transfusion-dependent patients with beta-thalassemia major: the predominant role of cytomegalovirus.
For 9 months, 38 transfusion-dependent patients with beta-thalassemia, ranging in age from 3.4 to 19.1 years, were observed for serologic evidence of viral infections, by the collection of serial se... | 14 |
2,592 | Cytotoxic activity against HIV-infected monocytes by recombinant interleukin 2-activated natural killer cells.
Natural killer (NK) cells have long been known to aid in the control of viral infections by killing virus-infected cells, including those infected with human immunodeficiency virus (HIV).
Among the possible ... | 19 |
1,927 | Erythrocyte fatty acids, plasma lipids, and cardiovascular disease in rural China.
Cardiovascular disease (CVD) mortality (coronary heart disease, hypertensive heart disease, and stroke), plasma lipids, and red blood cell fatty acid composition were examined in an ecologic study in 65 rural counties in the People's Re... | 13 |
2,919 | Biomechanical strength of non-vascularised and vascularised diaphyseal bone transplants. An experimental study.
We studied the healing and torsional strength of non-vascularised (28) and vascularised (28) sections of tibial diaphyses in 56 cats.
Both types of graft achieved fracture union in the same period of time, ... | 20 |
2,632 | Evaluation of active control trials in AIDS.
In settings in which effective standard treatment exists, active control trials provide an ethically appealing approach to evaluating experimental therapies by allowing all patients to be randomized either to a promising new regimen or to the standard as it would be routine... | 19 |
784 | Technical aspects of biliary extracorporeal shock wave lithotripsy.
Radiologic imaging procedures play a major role in the evaluation of the potential patient for biliary extracorporeal shock wave lithotripsy, both during the procedure and in follow-up evaluation.
The treating physician must have a thorough knowledge... | 5 |
1,877 | The frequency-dependent behavior of cerebral autoregulation.
Cerebral autoregulation is a complex physiological process composed of both fast and slow components that may respond differently to different rates and patterns of blood pressure variation.
To assess the temporal nature of autoregulation, transcranial Dopp... | 13 |
1,156 | Neurologic complications of cocaine abuse.
The neurologic complications of cocaine toxicity are responsible for a major portion of the morbidity and mortality associated with cocaine.
Most of the complications appear to be related to the hyperadrenergic state induced by cocaine and may be treated symptomatically.
Di... | 9 |
2,072 | Changes in myocardial ischemic threshold during daily activities.
This study assesses the variations in myocardial ischemic threshold (heart rate at the onset of ischemia) during daily activities in patients with ischemic episodes on Holter monitoring.
Eighty patients with known coronary artery disease, positive trea... | 13 |
2,269 | The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two metaanalyses.
We performed 2 metaanalyses of placebo-controlled and comparative clinical trials to examine the relative efficacy and toxicity of methotrexate (MTX), injectable gold, D-penicillamine (DP), sulfasalazine (S... | 16 |
690 | The role of ERCP in children and adolescents.
The diagnostic and therapeutic role of ERCP in 42 patients ranging from 1 to 19 years of age is discussed.
ERCP provided useful additional information in 15 patients with biliary tract disease, 15 patients with pancreatic disease, and 9 patients with abdominal pain.
The ... | 5 |
3,232 | Hemifacial spasm in Rochester and Olmsted County, Minnesota, 1960 to 1984.
The incidence of hemifacial spasm in residents of Olmsted County, Minnesota, was studied by reviewing the medical records of patients residing in the community between 1960 and 1984.
The average annual incidence rate was 0.74 per 100,000 in me... | 22 |
1,071 | Epidural hematoma: an unusual presentation.
The authors present a patient with a traumatic epidural hematoma who complained only of headache and presented to the emergency department 48 hours after a fall.
Mental status and neurological examination were normal.
This delayed presentation is more commonly seen when a ... | 9 |
2,644 | Therapeutic approaches to neoplasms in AIDS.
The multifactorial etiology of Kaposi's sarcoma (KS), which is seen primarily in men, includes genetic predisposition and immunosuppression.
Recently, the KS seen in association with human immunodeficiency virus (HIV) infection has been shown to be mediated by the producti... | 19 |
661 | Bipolar versus total hip arthroplasty for avascular necrosis of the femoral head. A comparison.
In a relatively small series of cases the results of bipolar prostheses in avascular necrosis were inferior to those of total hip arthroplasty (THA).
Femoral loosening rates were not reduced by using bipolar prostheses.
T... | 4 |
2,473 | Increased testosterone in type I diabetic subjects with severe retinopathy.
Diabetic retinopathy rarely occurs before puberty, suggesting that changes in sex hormones may influence the development of this condition.
The authors measured serum testosterone, estradiol, DHEA-S, and sex hormone binding globulin levels in... | 17 |
2,099 | Additional salutary hemodynamic effects of the combined use of the paraaortic counterpulsation device and intraaortic balloon pump versus a paraaortic counterpulsation device alone.
The hemodynamic effects of the combined use of the paraaortic counterpulsation device (PACD) (stroke volume 65 ml) implanted on the ascen... | 13 |
1,117 | A review of techniques employed to estimate the number of motor units in a muscle.
Being the smallest functional units under neural control, motor units play an integral role in muscle physiology.
However, at the present time, there does not exist any widely accepted technique for quantifying or estimating the number... | 9 |
809 | Intrahepatic cholesterol stones: a rationale for dissolution therapy.
A case of primary cholesterol hepatolithiasis is reported.
Stone composition was documented by infrared spectroscopy, and the presence of cholesterol saturated bile was demonstrated using standard biochemical techniques.
The patient was treated wi... | 5 |
1,647 | Pharmacology of angiotensin-converting enzyme inhibitors as a guide to their use in congestive heart failure.
The pharmacokinetics of the angiotensin-converting enzyme (ACE) inhibitors are difficult to assess for several reasons.
First, these compounds exert their influence by inhibiting an intermediary enzyme of a c... | 13 |
3,272 | Muscle blood flow and muscle metabolism during exercise and heat stress.
The effect of heat stress on blood flow and metabolism in an exercising leg was studied in seven subjects walking uphill (12-17%) at 5 km/h on a treadmill for 90 min or until exhaustion.
The first 30 min of exercise were performed in a cool envi... | 22 |
2,265 | Abnormal essential fatty acid metabolism in Darier's disease.
Fatty acid levels in plasma and erythrocyte cell membranes were determined in 13 Danish patients with Darier's disease and 21 Danish controls.
Concentrations of the main dietary essential fatty acids, linoleic acid (18:2n-6) and alpha-linolenic acid (18:3n... | 16 |
3,278 | Aggressive granulomatous lesions in cementless total hip arthroplasty.
We describe six patients with aggressive granulomatous lesions around cementless total hip prostheses.
Two patients previously had a cemented prosthesis in the same hip.
The Lord prosthesis was used in five patients, the PCA in one.
Both prosthe... | 22 |
146 | In vivo assessment of antimicrobial agents against Toxoplasma gondii by quantification of parasites in the blood, lungs, and brain of infected mice.
The in vivo effects of antimicrobial agents against Toxoplasma gondii were evaluated in mice that were infected intraperitoneally with 10(4) tachyzoites of the RH strain ... | 2 |
1,410 | X linked hypophosphataemia: treatment, height gain, and nephrocalcinosis.
The clinical data of 18 patients with X linked hypophosphataemia were analysed retrospectively.
The height data were expressed as SD scores.
There was no difference in the final height of patients treated with vitamin D (or 1,25-dihydroxyvitam... | 11 |
2,937 | Two cases of fatal atlantoaxial distraction injury without fracture or rotation.
Atlantoaxial injuries, regardless of mechanism, typically result in bony injury.
We present two unusual cases of fatal traumatic C-1-C-2 distraction without associated fracture or rotation.
The ligamentous anatomy, common underlying str... | 20 |
2,220 | Cardiac transplantation for hypoplastic left heart syndrome: a modified technique [see comment]
A modified technique of infant orthotopic cardiac transplantation with arch reconstruction using bicaval cannulation is described, and the results in 4 infants with hypoplastic left heart syndrome are presented.
This techn... | 15 |
1,790 | The changing clinical spectrum of thromboangiitis obliterans (Buerger's disease).
Between 1970 and 1987, 112 patients were diagnosed as having thromboangiitis obliterans (TAO).
The age was 42 +/- 11 years (mean +/- SD; range, 20-75 years); 23% were women, and 7% were more than 60 years old when they were first diagno... | 13 |
1,804 | Depression and recovery of right ventricular function after cardiopulmonary bypass.
Transient left ventricular dysfunction is commonly described in association with cardiopulmonary bypass (CPB).
We evaluated changes in right ventricular (RV) function after elective cardiac surgery in 24 patients with normal preoperat... | 13 |
275 | Autologous bone marrow transplantation in multiple myeloma: identification of prognostic factors.
Multiple myeloma remains a universally fatal malignancy with a median survival time not exceeding 3 years.
A clinical trial was undertaken to determine feasibility and efficacy of marrow-ablative chemoradiotherapy suppor... | 3 |
896 | Plasma cross linked fibrin degradation products in pulmonary embolism.
Plasma concentrations of cross linked fibrin degradation products, a marker of intravascular thrombosis and fibrinolysis, were measured in 495 patients with suspected pulmonary embolism referred for ventilation-perfusion lung scanning to determine ... | 7 |
999 | Transtympanic endoscopic findings in patients with otitis media with effusion.
Using a fine, rigid endoscope (Olympus, SES-1711K), we examined the middle ear, including the tympanic orifice of the eustachian tube, of children with otitis media with effusion (OME) in its active stage (26 ears), in the convalescent stag... | 8 |
207 | Effect of somatostatin analogue (octreotide) on blood flow to endocrine tumors metastatic to the liver: angiographic evaluation.
The effect of an octapeptide analogue of somatostatin, octreotide, on tumor blood flow was evaluated with angiography in eight patients with hepatic endocrine tumors; one patient had primary... | 3 |
2,257 | A method for the determination of UVA protection for normal skin.
Although the UVB portion of the electromagnetic spectrum (290 to 320 nm) is responsible for most of the harmful effects of sunlight on the skin, wavelengths in the UVA region also contribute to photodamage.
A simple and rapid clinical test, the sun pro... | 16 |
1,028 | Asymptomatic congenital cytomegalovirus infection. Audiologic, neuroradiologic, and neurodevelopmental abnormalities during the first year.
Twenty-eight infants with asymptomatic congenital cytomegalovirus infection and 13 control infants were followed up prospectively.
Congenital sensorineural hearing loss was docum... | 8 |
3,293 | Pilot study of nicardipine for acute ischemic stroke.
The author performed a pilot study of nicardipine (NC), a Ca(+)+ channel blocker, to study its dosing, toxicity, and possible efficacy for hemispheric cerebral infarction within 12 hours (mean 6.9 hr) of onset to determine the advisability of proceeding with a mult... | 22 |
2,417 | Calcitonin gene-related peptide and induction of hyperglycemia in conscious rats in vivo.
The effect of calcitonin gene-related peptide (CGRP) on glucose metabolism was investigated in conscious and unrestrained rats in vivo.
Intravenous injection of rat CGRP (5.67 and 0.567 nmol/kg) caused a significant, dose-depend... | 17 |
1,069 | Brain imaging abnormalities in mental disorders of late life.
Psychiatric inpatients with dementia (N = 61) or depression (N = 67) in late life were 2.6 times more likely to manifest magnetic resonance imaging abnormalities of the brain than were elderly controls (N = 44).
Controlling for the effects of age and gende... | 9 |
3,270 | Premenstrual syndromes defined by symptom-sets.
An analysis is made of the pattern of presenting premenstrual symptoms in randomly selected general practice patients from the Wellington region, New Zealand.
Participants, 1826 healthy women 16-54 years old whose characteristics were reasonably representative of the ad... | 22 |
2,907 | Frostbite. Methods to minimize tissue loss.
If frostbite is to be treated successfully, direct and indirect effects of injury must be understood.
Rapid rewarming helps to preserve tissue by limiting the amount of direct cellular injury.
Selective management of blisters helps protect the subdermal plexus, and applica... | 20 |
2,454 | Cholesterol-lowering effects of soluble-fiber cereals as part of a prudent diet for patients with mild to moderate hypercholesterolemia.
Soluble-fiber breakfast cereals were examined for their cholesterol-lowering ability in 58 male patients with mild to moderate hypercholesterolemia in a randomized, double-blind, pla... | 17 |
2,856 | Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study
The prevalence of comorbid alcohol, other drug, and mental disorders in the US total community and institutional population was determined from 20,291 persons interviewed in the National Instit... | 20 |
2,400 | Biometry of the crystalline lens in early-onset diabetes
Lenticular biometry on non-cataractous lenses has been studied by means of Scheimpflug photography and digital image analysis in 153 patients with early-onset insulin-dependent diabetes and 153 non-diabetic controls.
Anteroposterior axial lens thickness, corti... | 17 |
1,639 | Left ventricular dilatation and pulmonary thallium uptake after single-photon emission computer tomography using thallium-201 during adenosine-induced coronary hyperemia.
This study examined the implications of left ventricular (LV) dilatation and increased pulmonary thallium uptake during adenosine-induced coronary h... | 13 |
2,986 | The effect of screws and pegs on the initial fixation stability of an uncemented unicondylar knee replacement.
Two uncemented unicompartmental tibial components were examined for initial fixation stability.
A conventional design that employed a single posteriorly angled peg was compared with a new design that was hel... | 22 |
1,963 | An analysis of randomized trials evaluating the effect of cholesterol reduction on total mortality and coronary heart disease incidence.
The primary aim of this study was to estimate the relation between cholesterol reduction and total mortality and coronary heart disease (CHD) incidence.
Secondarily, the clinical is... | 13 |
3,173 | Percutaneous balloon dilatation of benign biliary strictures.
Percutaneous biliary dilatation is an effective alternative to surgical management of benign biliary strictures that has low morbidity and no reported mortality.
Reported success rates for this procedure range from 40% to 90% depending on the size of the s... | 22 |
654 | Focal fibrocartilaginous dysplasia associated with tibia vara.
Focal fibrocartilaginous dysplasia of the tibia at the insertion of the pes anserinus (the expanded tendinous insertion of the gracilis, sartorius, and semitendinous muscles) is a rare unilateral lesion with a characteristic deformity of the proximal tibia... | 4 |
449 | Characterization in vitro of a human tumor necrosis factor-binding protein. A soluble form of a tumor necrosis factor receptor.
Tumor necrosis factor (TNF) is a pleiotropic mediator of inflammatory responses.
A cysteine-rich, highly glycosylated 30-kD TNF-binding protein (TNF-BP) purified from urine may have a role i... | 3 |
2,722 | Differences in knowledge of and risk factors for AIDS between Hispanic and non-Hispanic women attending an urban family planning clinic.
Risk factors for AIDS, contraceptive use, seroprevalence of HIV, and level of knowledge before and after an AIDS education session were assessed for 657 clients attending a family pl... | 19 |
2,105 | Early and late tamponade with the Novacor left ventricular assist system.
Cardiac tamponade can be a major complication after implantation of the Novacor left ventricular assist system (LVAS).
Between 1987 and 1989, 14 patients received an LVAS as a bridge to cardiac transplantation: 3 developed early tamponade (33 +... | 13 |
3,313 | Current trends in suture fixation of posterior chamber intraocular lenses.
Corneal surgeons were surveyed with regard to their technique of suture fixation of posterior chamber intraocular lenses in the absence of posterior capsular support.
Fifty-nine percent of the 260 respondents stated they perform the procedure ... | 22 |
3,152 | Hemiparkinsonism-hemiatrophy syndrome: clinical and neuroradiologic features.
We evaluated 11 patients with hemiparkinson-hemiatrophy syndrome, 6 with body and contralateral cerebral hemispheric hemiatrophy, 4 with only body hemiatrophy, and 1 with just brain hemiatrophy.
The mean age of symptom onset was 38.1 years ... | 22 |
2,314 | Cicatricial pemphigoid. Identification of two distinct sets of epidermal antigens by IgA and IgG class circulating autoantibodies.
A patient with severe cicatricial pemphigoid demonstrated both in vivo bound and circulating anti-basement membrane zone antibodies of the IgA and IgG classes.
Complement component 3 (C3)... | 16 |
1,618 | Lower extremity percutaneous transluminal angioplasty: multifactorial analysis of morbidity and mortality.
We analyzed the outcome of 202 percutaneous transluminal angioplasty (PTA) procedures performed between 1983 and 1989 to quantitate procedural risks and define factors associated with suboptimal results or immedi... | 13 |
1,851 | Dissociation of changes in cardiovascular mass and performance with angiotensin-converting enzyme inhibitors in Wistar-Kyoto and spontaneously hypertensive rats.
The effects of angiotensin-converting enzyme inhibitors on cardiovascular mass and function were measured in three groups of 22 week old male Wistar-Kyoto no... | 13 |
2,164 | Disseminated intravascular coagulation due to intravenous administration of hetastarch.
Disseminated intravascular coagulation occurred in a patient after intravenous administration of hetastarch.
The onset was acute within 3 hours after exposure to the agent and the course was fulminating.
The patient died in 48 ho... | 14 |
1,993 | Coronary artery disease in the octogenarian: angiographic spectrum and suitability for revascularization.
The angiographic findings of 84 consecutive octogenarians presenting with symptoms of coronary artery disease (CAD) were examined to determine the extent of CAD as well as suitability for both coronary artery bypa... | 13 |
372 | Preoperative cell-mediated immune function and the prognosis of patients with gastric carcinoma.
The cell-mediated immune function of 83 patients with gastric carcinoma was assessed preoperatively and the results were compared to that of 52 patients with benign lesions.
The data were subjected to an analysis in order... | 3 |
2,929 | Familial values as factors influencing long-term psychological adjustment of children after severe burn injury.
This study replicates earlier findings that children who survive severe burn injury do make positive psychological adjustment.
Family support and a family value of autonomy were predicted to be critical var... | 20 |
2,058 | Bone mineral density in spontaneous hypertension: differential effects of dietary calcium and sodium.
Dietary calcium and sodium have been postulated to modify both bone mineral status and blood pressure regulation in humans and animals.
The spontaneously hypertensive rat (SHR) manifests several defects in calcium me... | 13 |
1,170 | Neurodevelopmental outcome of children with evidence of periventricular leukomalacia on late MRI.
Fifteen children, 8 months of age or older, from a neonatal follow-up program underwent magnetic resonance imaging and neurologic, cognitive, and language evaluations.
Magnetic resonance imaging findings in all children ... | 9 |
946 | Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis.
To investigate the distribution of proteinase 3, the target antigen of anti-cytoplasmic antibodies (ACPA or C-ANCA), within the organelles of resting normal human polymorphonuclear l... | 7 |
2,115 | Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility, and relaxation.
We compared the activity and physiologic effects of cardiac angiotensin converting enzyme (ACE) using isovolumic hearts from... | 13 |
641 | An analysis of the effect of the Zielke operation on S-shaped curves in idiopathic scoliosis. A follow-up study revealing some skeletal and soft tissue factors involved in curve progression.
This article analyzes the fate of S-shaped idiopathic spinal curves during follow-up in 18 patients having the Zielke VDS operat... | 4 |
622 | Monosodium urate crystals stimulate phospholipase A2 enzyme activities and the synthesis of a phospholipase A2-activating protein.
Eicosanoids are important mediators of the inflammatory response to monosodium urate crystals (MSUC) that results in gout.
Phospholipase enzymes cleave fatty acids from membrane phospholi... | 4 |
3,266 | The case for porous-coated hip implants. The femoral side.
A series of 1163 total hip arthroplasties (THAs) using porous-coated femoral components were roentgenographically assessed for implant fixation.
For 959 primary THAs followed from two to 12 years, the femoral revision rate was 1% and the ten-year survivorship... | 22 |
3,280 | Endoscopic control of upper gastrointestinal bleeding.
It has been estimated that gastrointestinal (GI) bleeding occurs in more than 100,000 patients with peptic ulcer disease each year.
In 75-80% of the cases, bleeding will be self-limited.
A major predictor of persistent or recurrent bleeding is the magnitude of b... | 22 |
335 | Head and neck cancer and ageing: a retrospective study in 438 patients.
To evaluate whether age over 70 years represents a prognostic factor in head and neck cancer, we reviewed all cases observed between 1981 and 1984.
Four hundred and thirty-eight (438) patients were considered in relation to three age groups (less... | 3 |
2,820 | Alcohol withdrawal syndromes.
Current studies have begun to elucidate the pathophysiology of alcoholism and its withdrawal syndrome.
Newer benzodiazepines, beta-blockers, alpha-agonists, butyrophenones and calcium channel blocking agents, alone and in combination, have been studied recently in alcohol withdrawal.
Th... | 20 |
900 | Inhaler and spacer use in obstructive airway diseases.
The role of inhaled aerosols in the treatment of obstructive airway diseases is increasing for both immediate bronchodilation and prophylactic anti-inflammatory effects.
Inhaled aerosol agents are available in metered-dose inhaler and nebulizer forms.
Maximum th... | 7 |
767 | Gallstone disease in north India: clinical and ultrasound profile in a referral hospital.
We studied the prevalence of gallstones in patients with upper abdominal pain, heaviness, or discomfort by ultrasound examination of the gallbladder.
The actual ultrasound examination was performed by a clinical gastroenterologi... | 5 |
284 | Expression of pancreatic secretory trypsin inhibitor gene in human colorectal tumor.
Expression of pancreatic secretory trypsin inhibitor (PSTI) gene was examined by Northern blotting analyses in 31 human colorectal tumors that included two benign adenomas and 26 adenocarcinomas.
Among the total of 28 cases which pro... | 3 |
25 | Comparison of cilofungin and amphotericin B for therapy of murine candidiasis.
We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis.
Three different dosages of each drug plus controls were evaluated.
Statistically improved survival was noted only among m... | 0 |
337 | Human tumor fluorouracil trapping: clinical correlations of in vivo 19F nuclear magnetic resonance spectroscopy pharmacokinetics.
We previously reported that fluorouracil (5FU) accumulation and metabolism in human livers and tumors can be studied by in vivo nuclear magnetic resonance spectroscopy (NMRS).
We have exte... | 3 |
3,140 | The effects of an iron chelator on cellular injury induced by vascular stasis caused by hypothermia.
Rewarming of a cooled rabbit leg was associated with the generation of oxygen-derived free radicals, shown to be instrumental for tissue injury occurring during rewarming.
The present study used a compound that, by it... | 22 |
65 | Protection of mice against the Lyme disease agent by immunizing with recombinant OspA.
Lyme borreliosis is a tick-borne illness caused by Borrelia burgdorferi.
The gene for outer surface protein A (OspA) from B.
burgdorferi strain N40 was cloned into an expression vector and expressed in Escherichia coli.
C3H/HeJ m... | 0 |
1,890 | Silent myocardial ischemia: dilemma or blessing?
Developing an optimal strategy for the evaluation and management of patients with silent myocardial ischemia is extremely difficult.
Although otherwise healthy, asymptomatic individuals may be at risk of dying suddenly during exercise, neither exercise testing nor Holt... | 13 |
3,133 | Biologically inert synthetic dural substitutes. Appraisal of a medical-grade aliphatic polyurethane and a polysiloxane-carbonate block copolymer.
Two types of artificial membranes, a medical-grade aliphatic polyurethane and a polysiloxane-carbonate block copolymer, were tested as substitutes for dura in 24 and 12 rabb... | 22 |
3,044 | Upper GI bleeding in an urban hospital. Etiology, recurrence, and prognosis.
Acute upper gastrointestinal bleeding (UGIB) continues to be a common cause of hospital admission and morbidity and mortality.
This study reviews 469 patients admitted to a surgical service of an urban hospital.
There were 562 total admissi... | 22 |
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