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001/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2015,
+  "age_at_initial_diagnosis": 65,
+  "sex": "male",
+  "smoking_status": "former",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 28,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

002/InvasionFront_CD3_block19_x1_y7_patient002_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4397.7,
+    "Centroid Y µm": 19239.8,
+    "Num Detections": 24709,
+    "Num Negative": 23303,
+    "Num Positive": 1406,
+    "Positive %": 5.69,
+    "Num Positive per mm^2": 556.86
+  }
+}

002/InvasionFront_CD3_block19_x2_y7_patient002_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7046.3,
+    "Centroid Y µm": 19414.7,
+    "Num Detections": 18969,
+    "Num Negative": 18433,
+    "Num Positive": 536,
+    "Positive %": 2.826,
+    "Num Positive per mm^2": 241.86
+  }
+}

002/TumorCenter_CD3_block19_x1_y7_patient002_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4997.4,
+    "Centroid Y µm": 19839.5,
+    "Num Detections": 21397,
+    "Num Negative": 19709,
+    "Num Positive": 1688,
+    "Positive %": 7.889,
+    "Num Positive per mm^2": 709.32
+  }
+}

002/TumorCenter_CD3_block19_x2_y7_patient002_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7596.0,
+    "Centroid Y µm": 19514.7,
+    "Num Detections": 22153,
+    "Num Negative": 20462,
+    "Num Positive": 1691,
+    "Positive %": 7.633,
+    "Num Positive per mm^2": 668.52
+  }
+}

002/TumorCenter_CD8_block19_x2_y7_patient002_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 9045.2,
+    "Centroid Y µm": 28909.7,
+    "Num Detections": 23532,
+    "Num Negative": 22365,
+    "Num Positive": 1167,
+    "Positive %": 4.959,
+    "Num Positive per mm^2": 450.15
+  }
+}

102/InvasionFront_CD8_block20_x3_y6_patient102_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11818.7,
+    "Centroid Y µm": 15241.9,
+    "Num Detections": 17409,
+    "Num Negative": 17165,
+    "Num Positive": 244,
+    "Positive %": 1.402,
+    "Num Positive per mm^2": 104.93
+  }
+}

102/TumorCenter_CD8_block20_x3_y6_patient102_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10894.2,
+    "Centroid Y µm": 14917.1,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

102/TumorCenter_CD8_block20_x4_y6_patient102_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13392.9,
+    "Centroid Y µm": 14817.2,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

102/icd_codes.txt

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+Glottiskarzinom[C32.0 L]

102/ops_codes.txt

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+Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikal modifizierte Neck dissection in 4 Regionen[5-403.20 B] Ösophagomyotomie pharyngozervikal sonstige[5-420.1x ] Anlegen ösophagotracheale Fistel zur Einlage Stimmprothese[5-429.0 ] Einlegen einer Stimmprothese[5-319.9 ] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ]

102/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2014,
+  "age_at_initial_diagnosis": 72,
+  "sex": "male",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 12,
+  "adjuvant_treatment_intent": null,
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "yes"
+}

102/patient_pathological_data.json

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+{
+  "patient_id": "102",
+  "primary_tumor_site": "Larynx",
+  "pT_stage": "pT4a",
+  "pN_stage": "pN2b",
+  "grading": "G3",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 2.0,
+  "number_of_resected_lymph_nodes": 47,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "yes",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "<0.1",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": NaN
+}

102/surgery_description.txt

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+Laryngectomy, Neck dissection, and Tracheotomy with Voice Prosthesis

102/surgery_report.txt

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+Induction of anesthesia and intubation via the tracheostoma by the anesthetist. Then injection of Ultracaine. Entry with the small bore tube and inspection of the hypopharynx. There are no abnormalities here, the postcricoid region and both piriform sinuses are unremarkable. Then attempt to adjust the larynx. This is only possible with the smallest tube. The tumor has completely taken over the glottic plane and the glottis so that no lumen is visible. Then sterile washing and covering. Form an apron flap in the usual manner, integrating the tracheostoma. Suturing of the skin flap. Start with the neck dissection on the right side. Exposure of the sternocleidomastoid muscle. Exposure of the omohyoid muscle. Exposure of the submandibular gland and the digastric muscle. Exposure of the cervical vascular sheath with free preparation of the internal jugular vein. Exposure of the accessorius nerve. Clearing of levels II to V while sparing the plexus branches and the hypoglossal nerve and facial vein. Then turn to the opposite side. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Exposure of the nervus accessorius, the cervical vascular sheath and free preparation of the internal jugular vein. Clearing of levels II to V while sparing the plexus branches. Exposure of the hypoglossus and facial vein. Clearing of the medial neck block. Level VI was divided in the middle and added to the neck preparations on each side. Then dissection of the cervical vascular sheath from the larynx on both sides. Dissection of the thyroid gland from the larynx on both sides. Ligation of the upper laryngeal bundle on both sides. Exposure of the hyoid bone. Removal of the hyoid bone. Skeletonization of the larynx so that in the anterior region .............. Release of the piriform sinus on both sides. Then enter the mouth with the large Langenbeck spatula and lift the base of the tongue. Perform the pharyngotomy at this point. Pull out the epiglottis and open the pharynx along the epiglottis. This is very easy on the right side, on the left side the tumor appears to have grown into the medial area of the piriform sinus, so the mucosa must be removed more generously here. The entire larynx is detached so that it is only attached to the trachea and the cricoid cartilage. The larynx is removed below the cricoid cartilage and sent for a frozen section. The pathologist can no longer detect any tumor in the edges of the incision and the specimen is therefore resected in sano in the frozen section. Then transition to insertion of a Provox prosthesis. Entry with the trocar and creation of a tracheoesophageal fistula and insertion of a size 10 Provox prosthesis using the pull-through method. Then perform a posteromedial esophagomyotomy on the left side. Perform a myotomy on the sternocleidomastoid muscle to flatten the tracheostoma. Performing the pharyngeal suture with single button sutures. Perform another pharyngeal suture over the first pharyngeal suture, also with single button sutures. The constrictor pharyngeal muscle is then adapted as well as possible. This cannot be done in all places so that the pharynx does not narrow, but so that the largest part of the 3rd pharyngeal suture is still covered. Insertion of 2 Redon drainage tubes. Cut out the skin on the tracheostoma, as it is massively macerated by the previously placed tracheostoma. Then suture the skin to the trachea. Fold back the apron flap and complete the mucocutaneous anastomosis in the tracheal area and close the wound in two layers. Please do not feed orally postoperatively and carry out an X-ray gruel swallow after 10 days, then build up the diet when the pharyngeal suture is tight.

103/InvasionFront_CD3_block7_x1_y1_patient103_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4422.7,
+    "Centroid Y µm": 2173.8,
+    "Num Detections": 22038,
+    "Num Negative": 21471,
+    "Num Positive": 567,
+    "Positive %": 2.573,
+    "Num Positive per mm^2": 238.79
+  }
+}

103/InvasionFront_CD3_block7_x2_y1_patient103_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7071.3,
+    "Centroid Y µm": 2223.8,
+    "Num Detections": 25016,
+    "Num Negative": 24892,
+    "Num Positive": 124,
+    "Positive %": 0.4957,
+    "Num Positive per mm^2": 51.24
+  }
+}

103/InvasionFront_CD8_block7_x1_y1_patient103_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6996.3,
+    "Centroid Y µm": 2448.7,
+    "Num Detections": 17081,
+    "Num Negative": 16763,
+    "Num Positive": 318,
+    "Positive %": 1.862,
+    "Num Positive per mm^2": 166.42
+  }
+}

103/InvasionFront_CD8_block7_x2_y1_patient103_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 9594.9,
+    "Centroid Y µm": 2573.6,
+    "Num Detections": 20705,
+    "Num Negative": 20685,
+    "Num Positive": 20,
+    "Positive %": 0.0966,
+    "Num Positive per mm^2": 8.872
+  }
+}

103/TumorCenter_CD3_block7_x1_y1_patient103_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4230.0,
+    "Centroid Y µm": 2576.7,
+    "Num Detections": 17664,
+    "Num Negative": 17607,
+    "Num Positive": 57,
+    "Positive %": 0.3227,
+    "Num Positive per mm^2": 26.23
+  }
+}

103/TumorCenter_CD3_block7_x2_y1_patient103_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6796.4,
+    "Centroid Y µm": 2673.6,
+    "Num Detections": 18941,
+    "Num Negative": 18879,
+    "Num Positive": 62,
+    "Positive %": 0.3273,
+    "Num Positive per mm^2": 27.24
+  }
+}

103/TumorCenter_CD8_block7_x1_y1_patient103_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4022.9,
+    "Centroid Y µm": 2773.5,
+    "Num Detections": 22818,
+    "Num Negative": 22795,
+    "Num Positive": 23,
+    "Positive %": 0.1008,
+    "Num Positive per mm^2": 10.19
+  }
+}

103/TumorCenter_CD8_block7_x2_y1_patient103_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6571.5,
+    "Centroid Y µm": 2923.5,
+    "Num Detections": 25057,
+    "Num Negative": 25037,
+    "Num Positive": 20,
+    "Positive %": 0.0798,
+    "Num Positive per mm^2": 8.611
+  }
+}

103/history_text.txt

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+In the patient, a cT2 cN0 oropharyngeal carcinoma on the left was histologically confirmed during a panendoscopy. The CT scan showed the tumor in direct contact with the internal carotid artery without any definite signs of infiltration. In addition, a subtotal thrombosis of the left internal jugular vein was found. Sonographic and computed tomographic findings of cN0 neck status without evidence of distant metastases.

103/icd_codes.txt

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+Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 ]

103/ops_codes.txt

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+Weichgaumenteilresektion[5-272.1 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Transorale radikale Resektion des Pharynx [Pharyngektomie] mit Rekonstruktion mit freiem mikrovaskulär-anastomosierten Transplantat[5-296.04 ] Deckung mit freiem Radialis-Lappen Unterarm[5-858.73 L] Entnahme myokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.23 L] Entnahme von Vollhaut aus der Leistenregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Permanente Tracheotomie[5-312.0 ] Wechsel vaskuläres Implantat[5-394.3 ] Kontinuierliche Sogbehandlung bei einer Vakuumversiegelung an bis zu 7 Tagen[8-190.10 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B]

103/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2012,
+  "age_at_initial_diagnosis": 70,
+  "sex": "male",
+  "smoking_status": "former",
+  "primarily_metastasis": "no",
+  "survival_status": "deceased",
+  "survival_status_with_cause": "deceased tumor specific",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 19,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

103/patient_pathological_data.json

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+{
+  "patient_id": "103",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT2",
+  "pN_stage": "pN0",
+  "grading": "G3",
+  "hpv_association_p16": "negative",
+  "number_of_positive_lymph_nodes": 0.0,
+  "number_of_resected_lymph_nodes": 51,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "yes",
+  "vascular_invasion_V": "yes",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": 13.0
+}

103/surgery_description.txt

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+Transoral resection, Defect coverage, Free flap (Radial), Neck dissection

103/surgery_report.txt

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+First, a pharyngoscopy is performed to determine the exact extent of the tumor: An exophytic mass is found on the left oropharyngeal side wall. Tumor growth begins at the posterior palatal arch with transition to the lateral pharyngeal wall and to approximately one third of the posterior pharyngeal wall. The tonsil and the anterior palatal arch are not infiltrated macroscopically and palpatorily. Growth over the posterior palatal arch up to the vicinity of the parauvular mucosal triangle. Overall moderate palpatory displacement. After positioning the patient, first transoral tumor resection: To obtain an overview and safe resection, enter the anterior palatal arch, taking the tonsil with you. Entering the anterior palatal arch. Release of the tonsil using the dissection technique. Behind the tonsil without direct contact, but according to ....................... the tumorous mass is now encountered. First cut around the mass on all sides with an electric knife. Resection up to the middle of the posterior pharyngeal wall. Problem-free loosening and resection of the tumor to the caudal and medial border. Complete removal of the posterior palatal arch. After loosening the edges in depth, careful dissection. However, a good displacement layer is now visible here, so that the tumor can be completely resected transorally macroscopically in sano. Circumscribed exposed fatty tissue from the neck, but no direct contact with the carotid artery as described in the CT scan. The tumor is now sent macroscopically in toto for frozen section diagnostics. If the resection in the area of the parauvular triangle on the posterior palatal arch is macroscopically scarce, a complete resection is performed here as well as a covering final margin sample, which is also sent for frozen section diagnostics. The tumor is now diagnosed in sano on all sides; only in the area of the caudal pharyngeal margin is there a clear alteration with questionable CIS. A new resection is therefore performed here, which is diagnosed as completely tumor-free in the frozen section diagnostics. Also basal free conditions. The deep wound bed is also resected later via pharyngotomy and placement of the vascular pedicle. After careful hemostasis, the neck is dissected on the left side: after injection of xylocaine with added adrenaline, the skin incision on the anterior edge of the sternocleidomastoid muscle is modified in a curved fashion. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure and careful preservation of the external jugular vein, which is very pronounced. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Release of the anterior neck preparation with careful protection of the superior thyroid artery and vein, the hypoglossal nerve and the cervical vein. Free preparation of the internal jugular vein. The vein shows clear wall changes, palpation with residual flow, no evidence of inflammatory changes, therefore the vein is left intact. Clear collateral formation with strong external jugular vein and anterior jugular vein. Exposure of the accessorius nerve. Clearing of the accessorius triangle and level V with careful protection of the cervical plexus branches. Overall macroscopically no suspicious nodes. Irrigation of the wound. Now turn to pharyngotomy. Resection of the digastric muscle, exposure of the stylohyoid. Exposure of the cervical vascular sheath and the external carotid artery. Preservation of the superior thyroid artery, the lingual artery, the facial artery and the occipital artery. Blunt perforation of the pharynx in the direction of the resection area. Widen the pharyngotomy until an approximately 3 ˝ finger-wide shaft is created. Basal co-resection of the wound bed. Neck dissection of the right side and radialis graft harvesting from the lower left side are now performed in parallel. Neck dissection on the right: In principle the same procedure as on the opposite side. Skin incision on the front edge of the sternocleidomastoid muscle. Cut through the skin and subcutaneous tissue. Exposure and transection of the platysma. Creation of a platysma flap. Exposure and preservation of the external jugular vein. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the submandibular gland and the digastric muscle. Clearing out the anterior neck preparation while carefully protecting the superior thyroid artery and the hypoglossal nerve. Exposure and protection of the accessorius nerve. Clearing out the accessorius triangle while carefully protecting the nerve. Completion of level V with careful protection of the cervical plexus branches. Final wound inspection. Wound irrigation. In dry wound conditions, without macroscopically suspicious nodes, insertion of a 10 Redon drain and careful, two-layer wound closure. Removal of the radialis graft from the left forearm: After marking a graft measuring 13 x 6 cm in total, using a skin monitor, the graft is cut into a bloodless area. Initially radial exposure and removal of the cephalic vein. Exposure and preservation of the superficial radial nerve ramus, which can remain completely intact. Expose the distal vascular pedicle. Dissection of the vascular pedicle. Strictly subfascial release of the graft. The ulnar artery lies deep and is not exposed. Strictly subfascial dissection of the graft with careful clipping of the outgoing muscle branches. Removal of the monitor bed. In the antecubital fossa it can now be seen that the cephalic vein remains relatively slender and does not form a visible bridge to the radial vein area. However, the radial veins unite to form a strong, common vessel, hence clipping of the cephalic vein, isolation also artery and vein. After reopening of the tourniquet, regular hand perfusion and excellent graft perfusion. Minutious hemostasis. Removal of the graft after regular blood flow. Subsequently, after wound inspection, careful, two-layered wound closure and insertion of the full-thickness skin graft lifted from the right groin. A vacuum sealing pump is then applied, the Kramer splint is placed in the functional position and the arm is repositioned. Full-thickness skin harvesting from the groin: For this purpose, cutting around an oval piece of skin measuring 15 x just under 6 cm, strictly cutaneous elevation, subcutaneous mobilization. Hemostasis and wound inspection. Placement of a 10 Redon drain and strong, two-layer wound closure under moderate tension. Now insertion of the graft combined transorally and transcervically. This is now considerably more difficult due to significant swelling in the throat and tongue area. Good fit, but extremely laborious insertion due to the local conditions and tight spaces. Finally, adequate suture intact on all sides. Positioning of the vascular pedicle and the cervical skin monitor. In the meantime, the tracheotomy was also performed due to the swelling conditions described: For this, with very deep lying cricoid cartilage, skin incision at the level of the cricoid cartilage. Cut through. Cut through the skin and subcutaneous tissue. Exposure and transection of the very strong anterior jugular vein. Ligation of the infrahyoid muscles that represent the veins. Dissection of the musculature. Exposure of the cricoid cartilage and the thyroid isthmus, which is coagulated if very thin. Very deep trachea, therefore insertion between the 1st and 2nd tracheal ring. Creation of a broad-based pedunculated Björk flap. Difficult incision with a low-lying trachea, but finally a wide tracheotomy and problem-free intubation onto an 8-gauge low-cuff cannula, which is suture-fixed. This is followed by cervical vascular preparation. This involves conditioning the flap vessels and the strong facial artery, which corresponds most closely to the strong radial artery. Carefully adapt the vascular suture with 8.0 Ethilon. Subsequently, regular flow conditions with immediate venous return and excellent graft perfusion, therefore now conditioning of the external jugular vein. If the flow is good, measure a size 3.5 coupler and perform the venous anastomosis with the coupler without any problems. Subsequently, regular blood flow with renewed excellent vitality of the graft and the skin monitor. Positioning of the skin monitor and insertion and careful, two-layer wound closure after insertion of a 10 Redon drain. Vital graft conditions at the end of the operation. Transfer of the patient intubated to the intensive care unit. Conclusion: Intraoperative R0-resected cT2 cN0 oropharyngeal carcinoma on the left. Laborious but sufficient reconstruction using a radialis graft. Due to the laborious intake conditions, the evaluation of the dietary reconstruction .............. Swallowing function should only be evaluated from the 9th to 10th postoperative day. Cannula supply, depending on swallowing function. Please strictly avoid cervical pressure dressings and exercise extreme caution when manipulating a venous anastomosis that is directly subcutaneous.

104/InvasionFront_CD3_block1_x1_y7_patient104_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3947.9,
+    "Centroid Y µm": 18965.0,
+    "Num Detections": 18275,
+    "Num Negative": 17213,
+    "Num Positive": 1062,
+    "Positive %": 5.811,
+    "Num Positive per mm^2": 479.26
+  }
+}

104/InvasionFront_CD3_block1_x2_y7_patient104_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6521.5,
+    "Centroid Y µm": 19164.9,
+    "Num Detections": 22688,
+    "Num Negative": 20005,
+    "Num Positive": 2683,
+    "Positive %": 11.83,
+    "Num Positive per mm^2": 1075.3
+  }
+}

104/InvasionFront_CD8_block1_x1_y7_patient104_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4097.8,
+    "Centroid Y µm": 17515.7,
+    "Num Detections": 18396,
+    "Num Negative": 15806,
+    "Num Positive": 2590,
+    "Positive %": 14.08,
+    "Num Positive per mm^2": 1121.9
+  }
+}

104/InvasionFront_CD8_block1_x2_y7_patient104_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6621.5,
+    "Centroid Y µm": 17640.7,
+    "Num Detections": 21589,
+    "Num Negative": 17068,
+    "Num Positive": 4521,
+    "Positive %": 20.94,
+    "Num Positive per mm^2": 1834.7
+  }
+}

104/TumorCenter_CD3_block1_x1_y9_patient104_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3848.0,
+    "Centroid Y µm": 22713.0,
+    "Num Detections": 23780,
+    "Num Negative": 14205,
+    "Num Positive": 9575,
+    "Positive %": 40.26,
+    "Num Positive per mm^2": 3786.8
+  }
+}

104/TumorCenter_CD3_block1_x2_y9_patient104_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6346.6,
+    "Centroid Y µm": 22588.0,
+    "Num Detections": 22376,
+    "Num Negative": 15447,
+    "Num Positive": 6929,
+    "Positive %": 30.97,
+    "Num Positive per mm^2": 2830.1
+  }
+}

104/TumorCenter_CD8_block1_x1_y7_patient104_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6296.7,
+    "Centroid Y µm": 26236.1,
+    "Num Detections": 21642,
+    "Num Negative": 18685,
+    "Num Positive": 2957,
+    "Positive %": 13.66,
+    "Num Positive per mm^2": 1213.8
+  }
+}

104/TumorCenter_CD8_block1_x2_y7_patient104_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 8970.3,
+    "Centroid Y µm": 26286.1,
+    "Num Detections": 21717,
+    "Num Negative": 18499,
+    "Num Positive": 3218,
+    "Positive %": 14.82,
+    "Num Positive per mm^2": 1349.8
+  }
+}

104/icd_codes.txt

@@ -0,0 +1 @@
+Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R] Neubildung bösartig sekundär und onA Lymphknoten Kopf Gesicht Hals[C77.0 R]

104/ops_codes.txt

@@ -0,0 +1 @@
+Direkte diagnostische Laryngoskopie[1-610.0 ] Sonstige diagnostische Pharyngoskopie[1-611.x ] Lokale Exzision Wange[5-273.4 R] Radikale zervikale Lymphadenektomie [Neck dissection] radikal 5 Regionen[5-403.11 R] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 L] Freier Lappen mit mikrovaskuläre Anastomose Haut und Unterhaut Empfängerstelle Hals[5-905.05 ] Gestielte regionale Lappenplastik mit Fernlappen am Hals[5-906.25 ] Spalthaut Entnahmestelle sonstige[5-901.0x R] Wechsel eines vaskulären Implantates[5-394.3 ] Wechsel eines vaskulären Implantates[5-394.3 ] Temporäre Tracheotomie[5-311.0 ] Transfusion Erythrozytenkonzentrat 1 TE (Transfusionseinheit) bis unter 6 TE (Transfusionseinheiten)[8-800.c0 ]

104/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2016,
+  "age_at_initial_diagnosis": 55,
+  "sex": "male",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "deceased",
+  "survival_status_with_cause": "deceased tumor specific",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 59,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

104/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "104",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT1",
+  "pN_stage": "pN3",
+  "grading": "G2",
+  "hpv_association_p16": "negative",
+  "number_of_positive_lymph_nodes": 4.0,
+  "number_of_resected_lymph_nodes": 31,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.2",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": NaN
+}

104/surgery_description.txt

@@ -0,0 +1 @@
+Resection, Bilateral neck dissection, Tracheotomy, Defect coverage, Free flap (Radial), Pectoralis Major flap

104/surgery_report.txt

@@ -0,0 +1 @@
+Induction of anesthesia by the anesthesia colleagues. Entry with the Kleinsasser tube and inspection of the pharynx and larynx area. In the pharynx, an extensive exophytic mass can be seen in the area of the oropharynx, in the area of the tonsil lobe, infiltrating the anterior and posterior palatal arch and parts of the soft palate. The other pharyngeal areas and the larynx are unremarkable. Sterile washing and draping. Start with neck dissection on the right and left side in parallel. Right side, start with <CLINICIAN_NAME>. Skin incision so that the large cystic metastasis is cut around. A large area of skin must also be resected. Exposure of the sternocleidomastoid muscle in the caudal region. Exposure of the omohyoid muscle and exposure of the capsule of the mass. Dissection of the lower part of the internal jugular vein. Then take over by <CLINICIAN_NAME> and further release of the mass. The mass must be pushed away from the carotid artery. This is achieved without any problems in the area of the common carotid artery. In the bulb area, it can be seen that the external carotid artery is infiltrated by the tumor. The internal jugular vein is then ligated and the mass removed, taking with it the sternocleidomastoid muscle with which the mass has grown together. The hypoglossal nerve is also infiltrated and must be severed as well as the accessorius nerve. The plexus branches of the cervical plexus can be preserved. The vagus nerve can also be preserved. Ultimately, the entire neck preparation with the metastasis is removed en bloc. Only the common carotid artery and internal carotid artery as well as the vagus nerve and the border cord remain. At the same time, perform the neck dissection on the left side through <CLINICIAN_NAME> and <CLINICIAN_NAME>. Neck dissection on the left: Skin incision, transection of the cutaneous and subcutaneous tissue and the platysma. Subplatysmal dissection and elevation of the apron flap. Suturing of the apron flap. Exposure of the anterior border of the sternocleidomastoid muscle and dissection along the muscle in depth until the cervical plexus is exposed. Identification of the omohyoid muscle and dissection along the muscle to the hyoid bone. Identification of the accessorius nerve and the digastric muscle. Dissection medially to the hyoid bone. Release of the submandibular gland, which is left in place during dissection. Identification of the hypoglossal nerve. This can be safely spared. Dissection along the vein from caudal to cranial and detachment of the neck preparation. Sending in levels II, III, IV and V in individual preparations. Irrigation with hydrogen and Ringer and completion of the neck dissection on the left side without complications. Insertion of the tonsil plug and inspection of the tumor region. Incision of the tumor region with a safety margin of at least 1 cm in the oropharynx using the electric needle. Dissection with the needle as well as with scissors and bipolar forceps. The preparation is obtained en bloc and is placed on cork for frozen section. In the frozen section, all margins and also basal R0. The tumor resection creates a defect towards the neck. The tumor itself had no contact with the large metastasis and was still separated from it by a thin layer of tissue. Now measurement of the defect and lifting of the radialis graft from the left forearm by <CLINICIAN_NAME>. Lifting the radialis graft: Marking the graft on the distal forearm on the left side. S-shaped skin incision and proximal forearm. Exposure of the confluence and dissection of a superficial vein (cephalic vein) up to the radial flap edge. Incision along the marked skin incision down to the forearm fascia. Incision of the forearm fascia and subfascial preparation of the radialis graft. Care is taken to protect the external ramus of the radial nerve, particularly at the radial end. The ulnar artery can also be safely spared. Dissection of the distal section of the radial artery and ligation of the radial artery after prior control by clamping with a vascular clip. A good perfusion signal can be measured on the index finger during clamping. Then preparation of the radial artery graft from the depth under constant bipolar coagulation and placement of vessel clips on the perforator vessels. Dissection up to the crook of the elbow, reliable identification of the brachial artery, the ulnar artery and the interosseous artery. Separation of the radial artery after the exit of the interosseous artery. Separation of the veins and irrigation of the graft with heparin. Lift the split skin from the right thigh using <CLINICIAN_NAME> and <CLINICIAN_NAME>. Insertion of the graft from transcervical and transoral through <CLINICIAN_NAME>. Creation of the arterial and venous anastomosis. Arterial to the superior thyroid artery, venous to the facial vein and a second vein. The anastomosis is located on the left side. The stalk was guided over the larynx to the left. Then skin suture in the area of the left side of the neck and a second graft must be lifted to close the right side of the neck. A pectoralis major graft was harvested from the right side for this purpose. To do this, cut around a skin island 8 x 4 cm medial to the nipple. Then dissect down to the thoracic wall. Lifting of the petoral muscle from the thoracic wall. Detachment of the attachment of the pecotralis muscle from the sternum and humerus. The pedicle is clearly identified. The graft is pulled through a tunnel representing the theoretical deltopectoral flap. The deltopectoral flap was not lifted off, but only tunneled under medially. Dissection of a skin flap in the neck area, which is folded back. Fitting of the pectoralis major graft. Adjustment of the folded back neck skin in the sense of a plastic reconstruction. Beforehand, insertion of a Redon drain and completion of the procedure without complications. After the tumor resection, a tracheotomy was performed between the second and third tracheal cartilage in the usual manner. Insertion of a tracheal cannula. Suturing of the tracheostomy tube. Continue antibiotics for at least 24 hours. Flap checks in the usual manner. Presentation at the tumor conference after receipt of the histology. X-ray pelvic swallow after 14 days.

105/InvasionFront_CD3_block15_x1_y10_patient105_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6596.5,
+    "Centroid Y µm": 35556.2,
+    "Num Detections": 15209,
+    "Num Negative": 13700,
+    "Num Positive": 1509,
+    "Positive %": 9.922,
+    "Num Positive per mm^2": 849.5
+  }
+}

105/InvasionFront_CD3_block15_x2_y10_patient105_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 9220.1,
+    "Centroid Y µm": 35481.2,
+    "Num Detections": 5221,
+    "Num Negative": 4974,
+    "Num Positive": 247,
+    "Positive %": 4.731,
+    "Num Positive per mm^2": 401.44
+  }
+}

105/InvasionFront_CD8_block15_x1_y10_patient105_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4291.9,
+    "Centroid Y µm": 24799.2,
+    "Num Detections": 10879,
+    "Num Negative": 10277,
+    "Num Positive": 602,
+    "Positive %": 5.534,
+    "Num Positive per mm^2": 285.14
+  }
+}

105/InvasionFront_CD8_block15_x2_y10_patient105_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6808.1,
+    "Centroid Y µm": 24701.9,
+    "Num Detections": 6289,
+    "Num Negative": 6212,
+    "Num Positive": 77,
+    "Positive %": 1.224,
+    "Num Positive per mm^2": 65.08
+  }
+}