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001/InvasionFront_CD3_block2_x3_y9_patient001_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13442.9,
+    "Centroid Y µm": 35881.0,
+    "Num Detections": 21339,
+    "Num Negative": 18549,
+    "Num Positive": 2790,
+    "Positive %": 13.07,
+    "Num Positive per mm^2": 1318.7
+  }
+}

001/InvasionFront_CD3_block2_x4_y9_patient001_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16016.5,
+    "Centroid Y µm": 36030.9,
+    "Num Detections": 22226,
+    "Num Negative": 20639,
+    "Num Positive": 1587,
+    "Positive %": 7.14,
+    "Num Positive per mm^2": 737.02
+  }
+}

001/InvasionFront_CD8_block2_x3_y9_patient001_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 12293.5,
+    "Centroid Y µm": 23562.5,
+    "Num Detections": 18371,
+    "Num Negative": 9496,
+    "Num Positive": 8875,
+    "Positive %": 48.31,
+    "Num Positive per mm^2": 4363.9
+  }
+}

001/InvasionFront_CD8_block2_x4_y9_patient001_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14817.2,
+    "Centroid Y µm": 23687.5,
+    "Num Detections": 17943,
+    "Num Negative": 7553,
+    "Num Positive": 10390,
+    "Positive %": 57.91,
+    "Num Positive per mm^2": 4985.2
+  }
+}

001/TumorCenter_CD3_block2_x3_y9_patient001_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11019.2,
+    "Centroid Y µm": 21963.4,
+    "Num Detections": 22642,
+    "Num Negative": 20385,
+    "Num Positive": 2257,
+    "Positive %": 9.968,
+    "Num Positive per mm^2": 1143.1
+  }
+}

001/TumorCenter_CD3_block2_x4_y9_patient001_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13517.8,
+    "Centroid Y µm": 22113.3,
+    "Num Detections": 24686,
+    "Num Negative": 19049,
+    "Num Positive": 5637,
+    "Positive %": 22.83,
+    "Num Positive per mm^2": 2676.8
+  }
+}

001/TumorCenter_CD8_block2_x3_y9_patient001_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13193.0,
+    "Centroid Y µm": 22088.3,
+    "Num Detections": 15477,
+    "Num Negative": 5738,
+    "Num Positive": 9739,
+    "Positive %": 62.93,
+    "Num Positive per mm^2": 4877.6
+  }
+}

001/TumorCenter_CD8_block2_x4_y9_patient001_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 15666.7,
+    "Centroid Y µm": 22063.3,
+    "Num Detections": 19096,
+    "Num Negative": 6578,
+    "Num Positive": 12518,
+    "Positive %": 65.55,
+    "Num Positive per mm^2": 6063.4
+  }
+}

001/patient_pathological_data.json

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+{
+  "patient_id": "001",
+  "primary_tumor_site": "Hypopharynx",
+  "pT_stage": "pT4a",
+  "pN_stage": "pN2b",
+  "grading": "G3",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 3.0,
+  "number_of_resected_lymph_nodes": 61,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "yes",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "<0.1",
+  "histologic_type": "SCC_Basaloid",
+  "infiltration_depth_in_mm": 19.0
+}

002/InvasionFront_CD8_block19_x1_y7_patient002_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4122.8,
+    "Centroid Y µm": 27085.7,
+    "Num Detections": 23736,
+    "Num Negative": 22751,
+    "Num Positive": 985,
+    "Positive %": 4.15,
+    "Num Positive per mm^2": 383.91
+  }
+}

002/InvasionFront_CD8_block19_x2_y7_patient002_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6746.4,
+    "Centroid Y µm": 27310.5,
+    "Num Detections": 15540,
+    "Num Negative": 14768,
+    "Num Positive": 772,
+    "Positive %": 4.968,
+    "Num Positive per mm^2": 439.1
+  }
+}

002/TumorCenter_CD8_block19_x1_y7_patient002_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6471.6,
+    "Centroid Y µm": 28909.7,
+    "Num Detections": 21616,
+    "Num Negative": 19937,
+    "Num Positive": 1679,
+    "Positive %": 7.767,
+    "Num Positive per mm^2": 690.27
+  }
+}

002/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2016,
+  "age_at_initial_diagnosis": 62,
+  "sex": "male",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "yes",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 16,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

002/patient_pathological_data.json

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+{
+  "patient_id": "002",
+  "primary_tumor_site": "Larynx",
+  "pT_stage": "pT2",
+  "pN_stage": "pN2c",
+  "grading": "G3",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 3.0,
+  "number_of_resected_lymph_nodes": 48,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "yes",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": null,
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 9.0
+}

003/InvasionFront_CD3_block7_x1_y2_patient003_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4322.7,
+    "Centroid Y µm": 4772.5,
+    "Num Detections": 26548,
+    "Num Negative": 14240,
+    "Num Positive": 12308,
+    "Positive %": 46.36,
+    "Num Positive per mm^2": 4469.6
+  }
+}

062/InvasionFront_CD8_block7_x2_y12_patient062_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6071.8,
+    "Centroid Y µm": 29684.3,
+    "Num Detections": 19668,
+    "Num Negative": 18839,
+    "Num Positive": 829,
+    "Positive %": 4.215,
+    "Num Positive per mm^2": 348.93
+  }
+}

062/TumorCenter_CD3_block7_x1_y12_patient062_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3448.2,
+    "Centroid Y µm": 30358.9,
+    "Num Detections": 21151,
+    "Num Negative": 17571,
+    "Num Positive": 3580,
+    "Positive %": 16.93,
+    "Num Positive per mm^2": 1405.3
+  }
+}

062/TumorCenter_CD3_block7_x2_y12_patient062_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6071.8,
+    "Centroid Y µm": 30333.9,
+    "Num Detections": 21504,
+    "Num Negative": 18842,
+    "Num Positive": 2662,
+    "Positive %": 12.38,
+    "Num Positive per mm^2": 1080.2
+  }
+}

062/TumorCenter_CD8_block7_x1_y12_patient062_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3423.2,
+    "Centroid Y µm": 30084.1,
+    "Num Detections": 19298,
+    "Num Negative": 17049,
+    "Num Positive": 2249,
+    "Positive %": 11.65,
+    "Num Positive per mm^2": 1052.9
+  }
+}

062/TumorCenter_CD8_block7_x2_y12_patient062_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6021.8,
+    "Centroid Y µm": 30084.1,
+    "Num Detections": 22982,
+    "Num Negative": 21462,
+    "Num Positive": 1520,
+    "Positive %": 6.614,
+    "Num Positive per mm^2": 631.03
+  }
+}

062/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2007,
+  "age_at_initial_diagnosis": 53,
+  "sex": "female",
+  "smoking_status": null,
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 5,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

062/patient_pathological_data.json

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+{
+  "patient_id": "062",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT2",
+  "pN_stage": "pN2b",
+  "grading": "G2",
+  "hpv_association_p16": "negative",
+  "number_of_positive_lymph_nodes": 13.0,
+  "number_of_resected_lymph_nodes": 22,
+  "perinodal_invasion": "no",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": 11.0
+}

063/InvasionFront_CD3_block18_x1_y6_patient063_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3898.9,
+    "Centroid Y µm": 19486.7,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

063/InvasionFront_CD3_block18_x2_y6_patient063_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6421.6,
+    "Centroid Y µm": 19564.6,
+    "Num Detections": 10698,
+    "Num Negative": 10407,
+    "Num Positive": 291,
+    "Positive %": 2.72,
+    "Num Positive per mm^2": 208.47
+  }
+}

063/InvasionFront_CD8_block18_x1_y6_patient063_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4172.8,
+    "Centroid Y µm": 22837.9,
+    "Num Detections": 12084,
+    "Num Negative": 11918,
+    "Num Positive": 166,
+    "Positive %": 1.374,
+    "Num Positive per mm^2": 102.67
+  }
+}

063/InvasionFront_CD8_block18_x2_y6_patient063_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6721.4,
+    "Centroid Y µm": 22862.9,
+    "Num Detections": 14792,
+    "Num Negative": 14510,
+    "Num Positive": 282,
+    "Positive %": 1.906,
+    "Num Positive per mm^2": 148.61
+  }
+}

063/TumorCenter_CD3_block18_x1_y6_patient063_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3639.8,
+    "Centroid Y µm": 14434.5,
+    "Num Detections": 13786,
+    "Num Negative": 13687,
+    "Num Positive": 99,
+    "Positive %": 0.7181,
+    "Num Positive per mm^2": 54.42
+  }
+}

063/TumorCenter_CD3_block18_x2_y6_patient063_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6084.2,
+    "Centroid Y µm": 14504.8,
+    "Num Detections": 15280,
+    "Num Negative": 15126,
+    "Num Positive": 154,
+    "Positive %": 1.008,
+    "Num Positive per mm^2": 78.02
+  }
+}

063/TumorCenter_CD8_block18_x1_y6_patient063_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3498.1,
+    "Centroid Y µm": 15341.9,
+    "Num Detections": 16875,
+    "Num Negative": 16733,
+    "Num Positive": 142,
+    "Positive %": 0.8415,
+    "Num Positive per mm^2": 72.1
+  }
+}

063/TumorCenter_CD8_block18_x2_y6_patient063_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 5946.9,
+    "Centroid Y µm": 15366.9,
+    "Num Detections": 16299,
+    "Num Negative": 16149,
+    "Num Positive": 150,
+    "Positive %": 0.9203,
+    "Num Positive per mm^2": 74.84
+  }
+}