Datasets:

everycure
/

drug-list

id stringlengths 8 8	name stringlengths 5 37	translator_id stringlengths 9 29	drugbank_id stringlengths 7 12 ⌀	synonyms listlengths 0 7	aggregated_with listlengths 0 13	drug_class stringlengths 4 79 ⌀	therapeutic_area stringclasses 98 values	drug_function stringlengths 5 201 ⌀	drug_target stringlengths 2 221 ⌀	approved_usa stringclasses 3 values	is_antipsychotic bool 2 classes	is_sedative bool 2 classes	is_antimicrobial bool 2 classes	is_glucose_regulator bool 2 classes	is_chemotherapy bool 2 classes	is_steroid bool 2 classes	is_analgesic bool 2 classes	is_cardiovascular bool 2 classes	is_cell_therapy bool 2 classes	atc_main stringlengths 7 7 ⌀	atc_level_1 stringclasses 14 values	atc_level_2 stringclasses 79 values	atc_level_3 stringclasses 167 values	atc_level_4 stringlengths 5 5 ⌀	atc_level_5 stringlengths 7 7 ⌀	l1_label stringclasses 14 values	l2_label stringclasses 79 values	l3_label stringclasses 167 values	l4_label stringlengths 6 102 ⌀	l5_label stringlengths 5 28 ⌀	deleted bool 2 classes	deleted_reason stringclasses 8 values	new_id stringclasses 4 values	is_fda_generic_drug bool 2 classes	__index_level_0__ int64 0 1.82k
EC:00001	Abacavir	CHEBI:421707	DB01048	[]	[]	Nucleoside reverse transcriptase inhibitor	Antimicrobial	Antiviral	HIV	APPROVED	false	false	true	false	false	false	false	false	false	J05AF06	J	J05	J05A	J05AF	J05AF06	Antiinfectives for systemic use	Antivirals for systemic use	Direct acting antivirals	Nucleoside and nucleotide reverse transcriptase inhibitors	Abacavir	false	null	null	true	0
EC:00002	Abaloparatide	UNII:AVK0I6HY2U	DB05084	[]	[]	Parathyroid hormone analog	Endocrine; Musculoskeletal	Activates osteoblasts	parathyroid hormone-related protein (PTHrP) analog	APPROVED	false	false	false	false	false	false	false	false	false	H05AA04	H	H05	H05A	H05AA	H05AA04	Systemic hormonal preparations, excl. sex hormones and insulins	Calcium homeostasis	Parathyroid hormones and analogues	Parathyroid hormones and analogues	Abaloparatide	false	null	null	false	1
EC:00003	Abatacept	UNII:7D0YB67S97	DB01281	[]	[]	Selective T-cell costimulation blocker	Immune	Immunomodulator \| Selective T-cell costimualation modulator	binds to CD80 and CD86 on APCs, preventing them from binding to CD28 on T-cells.	APPROVED	false	false	false	false	false	false	false	false	false	L04AA24	L	L04	L04A	L04AA	L04AA24	Antineoplastic and immunomodulating agents	Immunosuppressants	Immunosuppressants	Selective immunosuppressants	Abatacept	false	null	null	false	2
EC:00004	Abemaciclib	CHEBI:233362	DB12001	[]	[]	CDK4/6 inhibitor	Targeted cancer therapy	Small molecule inhibitor	CDK4 and CDK6 inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L01EF03	L	L01	L01E	L01EF	L01EF03	Antineoplastic and immunomodulating agents	Antineoplastic agents	Protein kinase inhibitors, antineoplastic and immunomodulating agents	Cyclin-dependent kinase (cdk) inhibitors	Abemaciclib	false	null	null	false	3
EC:00005	Abiraterone	CHEBI:68642	DB05812	[ "Abiraterone acetate" ]	[]	Androgen synthesis inhibitor	Targeted cancer therapy	Hormonal chemotherapy	CYP17 enzyme inhibitor to inhibit testerone production	APPROVED	false	false	false	false	false	false	false	false	false	L02BX03	L	L02	L02B	L02BX	L02BX03	Antineoplastic and immunomodulating agents	Endocrine therapy antineoplastic and immunomodulating agents	Hormone antagonists and related agents	Other hormone antagonists and related agents in atc	Abiraterone	false	null	null	true	4
EC:00006	Abrocitinib	UNII:73SM5SF3OR	DB14973	[]	[]	JAK inhibitor	Immune	Immunosuppressant	JAK1 inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	D11AH08	D	D11	D11A	D11AH	D11AH08	Dermatologicals	Other dermatological preparations in atc	Other dermatological preparations in atc	Agents for dermatitis, excluding corticosteroids	Abrocitinib	false	null	null	false	5
EC:00007	Acalabrutinib	CHEBI:167707	DB11703	[]	[]	BTK inhibitor	Targeted cancer therapy	Small molecule inhibitor	BTK inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L01EL02	L	L01	L01E	L01EL	L01EL02	Antineoplastic and immunomodulating agents	Antineoplastic agents	Protein kinase inhibitors, antineoplastic and immunomodulating agents	Bruton's tyrosine kinase (btk) inhibitors	Acalabrutinib	false	null	null	false	6
EC:00008	Acamprosate	CHEBI:51041	DB00659	[ "Acamprosate calcium" ]	[]	Alcohol abstinence tool	Central nervous system	Reduce alcohol cravings	GABA agonist and partial NMDA antagonist	APPROVED	false	false	false	false	false	false	false	false	false	N07BB03	N	N07	N07B	N07BB	N07BB03	Nervous system drugs	Other nervous system drugs in atc	Drugs used in addictive disorders	Drugs used in alcohol dependence	Acamprosate	false	null	null	true	7
EC:00009	Acarbose	UNII:T58MSI464G	DB00284	[]	[]	α-glucosidase inhibitor	Endocrine	Antidiabetic	α-glucosidase inhibitor	APPROVED	false	false	false	true	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	8
EC:00010	Acebutolol	CHEBI:2379	DB01193	[]	[]	Beta blocker	Cardiovascular	Antihypertensive	Beta-1 antagonist	APPROVED	false	false	false	false	false	false	false	true	false	C07AB04	C	C07	C07A	C07AB	C07AB04	Cardiovascular system drugs	Beta-adrenergic blocking agents	Beta blocking agents	Beta blocking agents, selective	Acebutolol	false	null	null	true	9
EC:00011	Aceclofenac	CHEBI:31159	DB06736	[]	[]	NSAID	Immune	Antiinflammatory	Prostaglandin G/H synthase inhibitor	NOT_APPROVED	false	false	false	false	false	false	true	false	false	M01AB16	M	M01	M01A	M01AB	M01AB16	Musculo-skeletal system drugs	Antiinflammatory and antirheumatic products	Antiinflammatory and antirheumatic products, non-steroids	Acetic acid derivatives and related substances	Aceclofenac	false	null	null	false	10
EC:00012	Acenocoumarol	CHEBI:53766	DB01418	[]	[]	Vitamin K antagonist	Hematology	Anticoagulant	Vitamin K antagonist	NOT_APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	11
EC:00013	Acetaminophen	CHEBI:46195	DB00316	[ "Paracetamol" ]	[]	Other analgesic	Misc	Analgesic	null	APPROVED	false	false	false	false	false	false	true	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	12
EC:00014	Acetazolamide	CHEBI:27690	DB00819	[]	[]	Carbonic anhydrase inhibitor	Renal	Diuretic, ophthlamic, antiseizure	Carbonic anhydase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	13
EC:00015	Acetylcysteine	CHEBI:28939	DB06151	[ "N-acetylcysteine" ]	[]	Mucolytic agent	Respiratory; detoxifying agent	Mucolytic agent	Mech not known	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	14
EC:00016	Acipimox	CHEBI:94688	DB09055	[]	[]	Nicotinic acid derivative	Cardiovascular; Metabolic	Antilipemic agent	Inhibits triglyceride production	NOT_APPROVED	false	false	false	false	false	false	false	true	false	C10AD06	C	C10	C10A	C10AD	C10AD06	Cardiovascular system drugs	Lipid modifying agents	Lipid modifying agents, plain	Nicotinic acid and derivatives, lipid modifying, plain	Acipimox	false	null	null	false	15
EC:00017	Acitretin	CHEBI:50173	DB00459	[]	[]	Retinoid	Dermatology	null	Second gen retinoid	APPROVED	false	false	false	false	false	false	false	false	false	D05BB02	D	D05	D05B	D05BB	D05BB02	Dermatologicals	Antipsoriatics	Antipsoriatics for systemic use	Retinoids for treatment of psoriasis	Acitretin	false	null	null	true	16
EC:00018	Aclidinium	CHEBI:65346	DB08897	[ "Aclidinium bromide" ]	[]	Inhaled antimuscarinic (LAMA)	Respiratory	Bronchodilator	M3 antagonist, long-acting	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	17
EC:00019	Acoltremon	UNII:1L7BVT4Z4Z	DB19202	[]	[]	TRPM8 agonist	Ophthalmic	Increases tear production	Transient receptor potential melastatin 8 thermoreceptor (TRPM8) agonist	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	18
EC:00020	Acoramidis	UNII:T12B44A1OE	DB17999	[]	[]	Transthyretin (TTR) Stabilizer	Cardiovascular	Anti-amyloid	TTR stabilizer	APPROVED	false	false	false	false	false	false	false	true	false	C01EB25	C	C01	C01E	C01EB	C01EB25	Cardiovascular system drugs	Cardiac therapy drugs	Other cardiac preparations in atc	Other plain cardiac preparations in atc	null	false	null	null	false	19
EC:00021	Acrivastine	CHEBI:83168	DB09488	[]	[]	Histamine H1 antagonist	Immune	Antihistamine	Histamine H1 Antagonist	NOT_APPROVED	false	false	false	false	false	false	false	false	false	R06AX18	R	R06	R06A	R06AX	R06AX18	Respiratory system drugs	Antihistamines for systemic use	Antihistamines for systemic use	Other antihistamines for systemic use in atc	Acrivastine	false	null	null	false	20
EC:00022	Acyclovir	CHEBI:2453	DB00787	[ "Aciclovir" ]	[ "Valacyclovir", "Valaciclovir" ]	Viral DNA synthesis inhibitor	Antimicrobial	Antiviral	Herpes virus	APPROVED	false	false	true	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	21
EC:00023	Adagrasib	CHEBI:233309	DB15568	[]	[]	KRAS G12C inhibitor	Targeted cancer therapy	Small molecule inhibitor	KRAS G12C Inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L01XX77	L	L01	L01X	L01XX	L01XX77	Antineoplastic and immunomodulating agents	Antineoplastic agents	Other antineoplastic agents in atc	Other antineoplastic agents in atc	Adagrasib	false	null	null	false	22
EC:00024	Adalimumab	UNII:FYS6T7F842	DB00051	[]	[]	Anti-TNF	Immune	Immunosuppressant	anti-TNF-alpha	APPROVED	false	false	false	false	false	false	false	false	false	L04AB04	L	L04	L04A	L04AB	L04AB04	Antineoplastic and immunomodulating agents	Immunosuppressants	Immunosuppressants	Tumor necrosis factor alpha (tnf-alpha) inhibitors	Adalimumab	false	null	null	true	23
EC:00025	Adapalene	CHEBI:31174	DB00210	[]	[]	Retinoid	Dermatology	null	Retinoid-like	APPROVED	false	false	false	false	false	false	false	false	false	D10AD03	D	D10	D10A	D10AD	D10AD03	Dermatologicals	Anti-acne preparations	Anti-acne preparations for topical use	Retinoids for topical use in acne	Adapalene	false	null	null	true	24
EC:00026	Adefovir	CHEBI:2469	DB13868	[ "Adefovir dipivoxil" ]	[]	Viral DNA synthesis inhibitor	Antimicrobial	Antiviral	HBV	APPROVED	false	false	true	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	25
EC:00027	Adenosine	CHEBI:16335	DB00640	[]	[]	Class V antiarrhythmic	Cardiovascular	Antiarrhythmic	Adenosine receptor	APPROVED	false	false	false	false	false	false	false	true	false	C01EB10	C	C01	C01E	C01EB	C01EB10	Cardiovascular system drugs	Cardiac therapy drugs	Other cardiac preparations in atc	Other plain cardiac preparations in atc	Adenosine	false	null	null	true	26
EC:00028	Aducanumab	UNII:105J35OE21	DB12274	[]	[]	Anti-amyloid antibody	Central nervous system	Antidementia	Anti-amyloid	DISCONTINUED	false	false	false	false	false	false	false	false	false	N06DX03	N	N06	N06D	N06DX	N06DX03	Nervous system drugs	Psychoanaleptics	Anti-dementia drugs	Other anti-dementia drugs in atc	Aducanumab	false	null	null	false	27
EC:00029	Afamelanotide	CHEBI:136034	DB04931	[]	[]	Melanocortin receptor agonist	Dermatology	null	melanocortin receptor agonist	APPROVED	false	false	false	false	false	false	false	false	false	D02BB02	D	D02	D02B	D02BB	D02BB02	Dermatologicals	Emollients and protectives	Protectives against uv-radiation	Protectives against uv-radiation for systemic use	Afamelanotide	false	null	null	false	28
EC:00030	Afamitresgene autoleucel	DRUGBANK:DB18592	DB18592	[]	[]	Cell therapy	Cell therapy	TCR cell therapy	Targeting MAGE-A4 protein	APPROVED	false	false	false	false	false	false	false	false	true	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	29
EC:00031	Afatinib	CHEBI:61390	DB08916	[]	[]	EGFR inhibitor	Targeted cancer therapy	Small molecule inhibitor	EGFR, RTK	APPROVED	false	false	false	false	false	false	false	false	false	L01EB03	L	L01	L01E	L01EB	L01EB03	Antineoplastic and immunomodulating agents	Antineoplastic agents	Protein kinase inhibitors, antineoplastic and immunomodulating agents	Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors	Afatinib	false	null	null	false	30
EC:00032	Aflibercept	UNII:15C2VL427D	DB08885	[ "Ziv-aflibercept" ]	[]	VEGF inhibitor	Ophthalmic; Targeted cancer therapy	Small molecule inhibitor	VEGF inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	S01LA05	S	S01	S01L	S01LA	S01LA05	Sensory organ drugs	Ophthalmologicals	Ocular vascular disorder agents	Antineovascularisation agents	Aflibercept	false	null	null	true	31
EC:00033	Agalsidase alfa	UNII:2HLC17MX9G	DB15874	[ "Recombinant human alpha-galactosidase a", "Alpha galactosidase", "Agalsidase beta" ]	[]	Alpha-galactosidase replacement	Metabolic	Lysosomal enzyme replacement	Alpha-galactosidase replacement	NOT_APPROVED	false	false	false	false	false	false	false	false	false	A16AB03	A	A16	A16A	A16AB	A16AB03	Alimentary tract and metabolism drugs	Other alimentary tract and metabolism products in atc	Other alimentary tract and metabolism products in atc	Enzymes for alimentary tract and metabolism	Agalsidase alfa	false	null	null	false	32
EC:00034	Agomelatine	CHEBI:134990	DB06594	[]	[]	Atypical antidepressant	Central nervous system	Antidepressant	Melatonergic agonist and serotonergic antagonist	NOT_APPROVED	false	false	false	false	false	false	false	false	false	N06AX22	N	N06	N06A	N06AX	N06AX22	Nervous system drugs	Psychoanaleptics	Antidepressants	Other antidepressants in atc	Agomelatine	false	null	null	false	33
EC:00035	Albendazole	CHEBI:16664	DB00518	[]	[]	Antihelminthic	Antimicrobial	Antiparasitic	Antihelminthic	APPROVED	false	false	true	false	false	false	false	false	false	P02CA03	P	P02	P02C	P02CA	P02CA03	Antiparasitic products, insecticides and repellents	Anthelmintics	Antinematodal agents	Benzimidazole derivatives, antinematodal	Albendazole	false	null	null	true	34
EC:00036	Albuterol	CHEBI:2549	DB01001	[ "Salbutamol" ]	[]	Short acting beta-2 agonist	Respiratory	bronchodilator	Beta-2 agonist	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	35
EC:00037	Alcaftadine	CHEBI:71023	DB06766	[]	[]	Histamine H1 antagonist	Ophthalmic	Antihistamine	Histamine-1 antagonist	APPROVED	false	false	false	false	false	false	false	false	false	S01GX11	S	S01	S01G	S01GX	S01GX11	Sensory organ drugs	Ophthalmologicals	Decongestants and antiallergics	Other antiallergics in atc	Alcaftadine	false	null	null	true	36
EC:00038	Alclometasone	CHEBI:31184	DB00240	[ "Alclometasone dipropionate" ]	[]	Glucocorticoid	Dermatology	Antiinflammatory	Glucocorticoid receptor agonist	APPROVED	false	false	false	false	false	true	false	false	false	D07AB10	D	D07	D07A	D07AB	D07AB10	Dermatologicals	Corticosteroids, dermatological preparations	Corticosteroid dermatological preparations, plain	Corticosteroids, moderately potent (group ii)	Alclometasone	false	null	null	true	37
EC:00039	Aldesleukin	UNII:M89N0Q7EQR	DB00041	[]	[]	IL-2	Targeted cancer therapy	Immunostimulant	Interleukin (human recombinant IL-2)	APPROVED	false	false	false	false	false	false	false	false	false	L03AC01	L	L03	L03A	L03AC	L03AC01	Antineoplastic and immunomodulating agents	Immunostimulants	Immunostimulants	Interleukins	Aldesleukin	false	null	null	false	38
EC:00040	Alectinib	CHEBI:90936	DB11363	[]	[]	ALK inhibitor	Targeted cancer therapy	Small molecule inhibitor	ALK inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L01ED03	L	L01	L01E	L01ED	L01ED03	Antineoplastic and immunomodulating agents	Antineoplastic agents	Protein kinase inhibitors, antineoplastic and immunomodulating agents	Anaplastic lymphoma kinase (alk) inhibitors	Alectinib	false	null	null	false	39
EC:00041	Alemtuzumab	UNII:3A189DH42V	DB00087	[]	[]	Anti-CD52	Targeted cancer therapy	Monoclonal antibody therapy	Anti-CD52	APPROVED	false	false	false	false	false	false	false	false	false	L04AG06	L	L04	L04A	L04AG	L04AG06	Antineoplastic and immunomodulating agents	Immunosuppressants	Immunosuppressants	Monoclonal antibodies	Alemtuzumab	false	null	null	false	40
EC:00042	Alendronic acid	CHEBI:2567	DB00630	[ "Alendronate" ]	[]	Bisphosphonate	Musculoskeletal	Inhibit osteoclast-mediated bone resorption	FPPS inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	M05BA04	M	M05	M05B	M05BA	M05BA04	Musculo-skeletal system drugs	Drugs for treatment of bone diseases	Drugs affecting bone structure and mineralization	Bisphosphonate drugs affecting bone structure and mineralization	Alendronic acid	false	null	null	true	41
EC:00043	Alfentanil	CHEBI:2569	DB00802	[]	[]	Opioid	Central nervous system	Analgesic	Mu-opioid receptors	NOT_APPROVED	false	false	false	false	false	false	true	false	false	N01AH02	N	N01	N01A	N01AH	N01AH02	Nervous system drugs	Anesthetics	Anesthetics, general	Opioid anesthetics	Alfentanil	false	null	null	false	42
EC:00044	Alfuzosin	CHEBI:51141	DB00346	[ "Alfuzosin hydrochloride" ]	[]	Alpha blocker	Urological	Smooth muscle relaxer in bladder and prostate	Alpha-1 blockers	APPROVED	false	false	false	false	false	false	false	false	false	G04CA01	G	G04	G04C	G04CA	G04CA01	Genito urinary system and sex hormones	Urologicals	Drugs used in benign prostatic hypertrophy	Alpha-adrenoreceptor antagonists, benign prostatic hypertrophy	Alfuzosin	false	null	null	true	43
EC:00045	Alglucosidase alfa	UNII:DTI67O9503	DB01272	[]	[]	GAA replacement	Metabolic	Lysosomal enzyme replacement	alpha-glucosidase enzyme replacement	APPROVED	false	false	false	false	false	false	false	false	false	A16AB07	A	A16	A16A	A16AB	A16AB07	Alimentary tract and metabolism drugs	Other alimentary tract and metabolism products in atc	Other alimentary tract and metabolism products in atc	Enzymes for alimentary tract and metabolism	Alglucosidase alfa	false	null	null	false	44
EC:00046	Alirocumab	UNII:PP0SHH6V16	DB09302	[]	[]	PCSK9 inhibitor	Cardiovascular	Lipid-lowering	PCSK9 inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	C10AX14	C	C10	C10A	C10AX	C10AX14	Cardiovascular system drugs	Lipid modifying agents	Lipid modifying agents, plain	Other lipid modifying agents in atc	Alirocumab	false	null	null	false	45
EC:00047	Aliskiren	CHEBI:601027	DB09026	[]	[]	Renin inhibitor	Cardiovascular	Antihypertensive	Renin inhibitor	APPROVED	false	false	false	false	false	false	false	true	false	C09XA02	C	C09	C09X	C09XA	C09XA02	Cardiovascular system drugs	Agents acting on the renin-angiotensin system	Other agents acting on the renin-angiotensin system in atc	Renin-inhibitors	Aliskiren	false	null	null	true	46
EC:00048	Alitretinoin	CHEBI:50648	DB00523	[]	[]	Retinoid	Targeted cancer therapy; Dermatology	Vitamin A derivative	retinoid / retinoic acid derivative	NOT_APPROVED	false	false	false	false	false	false	false	false	false	D11AH04	D	D11	D11A	D11AH	D11AH04	Dermatologicals	Other dermatological preparations in atc	Other dermatological preparations in atc	Agents for dermatitis, excluding corticosteroids	Alitretinoin	false	null	null	true	47
EC:00049	Allopurinol	CHEBI:40279	DB00437	[]	[]	Xanthine Oxidase Inhibitor	Musculoskeletal	Antigout agent \| decreases uric acid	Xanthine oxidase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	M04AA01	M	M04	M04A	M04AA	M04AA01	Musculo-skeletal system drugs	Antigout preparations	Antigout preparations	Preparations inhibiting uric acid production	Allopurinol	false	null	null	true	48
EC:00050	Almotriptan	CHEBI:520985	DB00918	[]	[]	Triptan antimigraine	Central nervous system	Antimigraine	selective serotonin (5-HT1) agonist	APPROVED	false	false	false	false	false	false	false	false	false	N02CC05	N	N02	N02C	N02CC	N02CC05	Nervous system drugs	Analgesics	Antimigraine preparations	Selective serotonin (5ht1) agonists	Almotriptan	false	null	null	true	49
EC:00051	Alogliptin	CHEBI:72323	DB06203	[]	[]	DDP-4 inhibitor	Endocrine	Antidiabetic	DDP-4 inhibitor	APPROVED	false	false	false	true	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	50
EC:00052	Alosetron	CHEBI:253342	DB00969	[]	[]	Serotonin 5-HT3 antagonist antiemetic	Gastrointestinal	Anti-diarrheal	selective serotonin (5-HT3) antagonist	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	51
EC:00053	Alpelisib	CHEBI:93752	DB12015	[]	[]	PI3K inhibitor	Targeted cancer therapy	Small molecule inhibitor	PI3K-alpha selective inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	52
EC:00054	Alpha-1-proteinase inhibitor	DRUGBANK:DB00058	DB00058	[ "Human alpha1-proteinase inhibitor" ]	[]	Alpha-1 proteinase inhibitor	Respiratory	Enzyme replacement therapy	Alpha-1 proteinase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	53
EC:00055	Alprazolam	CHEBI:2611	DB00404	[]	[]	Benzodiazepine	Central nervous system	Sedative	GABA-A agonist	APPROVED	false	true	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	54
EC:00056	Alprostadil	CHEBI:15544	DB00770	[]	[]	Prostaglandin analog	Urological	Vasodilator	prostaglandin E1 analog	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	55
EC:00057	Alteplase	UNII:1RXS4UE564	DB00009	[]	[]	Plasminogen activator	Hematology	Thombolytic	tissue plasminogen activator	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	56
EC:00058	Aluminium hydroxide	CHEBI:33130	DB06723	[ "Aluminum hydroxide", "Algeldrate" ]	[]	Antacid	Gastrointestinal	Antacid	Antacid	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	57
EC:00059	Alvimopan	CHEBI:135686	DB06274	[]	[]	Peripherally acting mu-opioid receptor antagonists (PAMORAs)	Gastrointestinal	Increase gastric motility	Opioid antagonist	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	58
EC:00060	Amantadine	CHEBI:2618	DB00915	[ "Amantadine hydrochloride" ]	[]	Amantadine	Central nervous system	Antiparkinson	NMDA receptor agonist	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	59
EC:00061	Ambrisentan	CHEBI:135949	DB06403	[]	[]	Endothelin receptor antagonist	Respiratory	Vasodilator	Endothelin receptor antagonist	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	60
EC:00062	Amcinonide	CHEBI:31199	DB00288	[]	[]	Glucocorticoid	Dermatology	Antiinflammatory	Glucocorticoid receptor agonist	APPROVED	false	false	false	false	false	true	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	61
EC:00063	Amifampridine	CHEBI:135948	DB11640	[]	[]	Neuronal potassium channel blocker	Central nervous system; Peripheral nervous system	Increase acetylcholine release	Potassium channel antagonist	APPROVED	false	false	false	false	false	false	false	false	false	N07XX05	N	N07	N07X	N07XX	N07XX05	Nervous system drugs	Other nervous system drugs in atc	Other nervous system drugs in atc	Other nervous system drugs in atc	Amifampridine	false	null	null	false	62
EC:00064	Amifostine	CHEBI:2636	DB01143	[]	[]	Free radical scavenger	Chemotherapy adjunct	Chemoprotective agent	Free radical scavenger	APPROVED	false	false	false	false	false	false	false	false	false	V03AF05	V	V03	V03A	V03AF	V03AF05	Various drug classes in atc	All other therapeutic products	All other therapeutic products	Detoxifying agents for antineoplastic treatment	Amifostine	false	null	null	false	63
EC:00065	Amikacin	CHEBI:2637	DB00479	[]	[]	Aminoglycoside antibiotic	Antimicrobial	Antibiotic	Aminoglycoside	APPROVED	false	false	true	false	false	false	false	false	false	J01GB06	J	J01	J01G	J01GB	J01GB06	Antiinfectives for systemic use	Antibacterials for systemic use	Aminoglycoside antibacterials	Other aminoglycosides in atc	Amikacin	false	null	null	true	64
EC:00066	Amiloride	CHEBI:2639	DB00594	[ "Amiloride hydrochloride" ]	[]	ENaC Blocker	Cardiovascular; Renal	Diuretic	ENaC antagonist	APPROVED	false	false	false	false	false	false	false	true	false	C03DB01	C	C03	C03D	C03DB	C03DB01	Cardiovascular system drugs	Diuretics	Aldosterone antagonists and other potassium-sparing agents	Other potassium-sparing agents in atc	Amiloride	false	null	null	true	65
EC:00067	Aminobenzoate potassium	UNII:41KZS5432U	DBSALT002730	[ "Aminobenzoic acid", "Vitamin b10", "Potassium aminobenzoate", "Potassium p-aminobenzoate" ]	[]	Vitamin B10	Supplement	Vitamin B supplement	Vitamin B10	APPROVED	false	false	false	false	false	false	false	false	false	D11AX23	D	D11	D11A	D11AX	D11AX23	Dermatologicals	Other dermatological preparations in atc	Other dermatological preparations in atc	Other dermatological preparations in atc	Aminobenzoate potassium	false	null	null	false	66
EC:00068	Aminocaproic acid	CHEBI:16586	DB00513	[]	[]	Antifibrinolytic	Hematology	Hemostatic agent	Plasminogen antagonist	APPROVED	false	false	false	false	false	false	false	false	false	B02AA01	B	B02	B02A	B02AA	B02AA01	Blood and blood forming organ drugs	Antihemorrhagics	Antifibrinolytics	Antifibrinolytic amino acids	Aminocaproic acid	false	null	null	true	67
EC:00069	Aminolevulinic acid	CHEBI:17549	DB00855	[]	[]	PDT photosensitizer	Targeted cancer therapy; Dermatology	photosensitizing agent	protoporphyrin IX precursor	APPROVED	false	false	false	false	false	false	false	false	false	L01XD04	L	L01	L01X	L01XD	L01XD04	Antineoplastic and immunomodulating agents	Antineoplastic agents	Other antineoplastic agents in atc	Sensitizers used in photodynamic/radiation therapy	Aminolevulinic acid	false	null	null	false	68
EC:00070	Aminophylline	CHEBI:2659	DB01223	[]	[]	Methylxanthine	Respiratory	Bronchodilator	PDE-3A inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	R03DA05	R	R03	R03D	R03DA	R03DA05	Respiratory system drugs	Drugs for obstructive airway diseases	Other systemic drugs for obstructive airway diseases in atc	Xanthines, systemic for obstructive airway disease	Aminophylline	false	null	null	true	69
EC:00071	Aminosalicylic acid	CHEBI:27565	DB00233	[ "Para-aminosalicylic acid", "4-aminosalicylic acid", "Aminosalicylate sodium anhydrous" ]	[]	Antimetabolite antitubercular	Antimicrobial	Antibiotic	Antitubercular agent	APPROVED	false	false	true	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	70
EC:00072	Amiodarone	CHEBI:2663	DB01118	[ "Amiodarone hydrochloride" ]	[]	Class III antiarrhythmic	Cardiovascular	Antiarrhythmic	Potassium channel blocker	APPROVED	false	false	false	false	false	false	false	true	false	C01BD01	C	C01	C01B	C01BD	C01BD01	Cardiovascular system drugs	Cardiac therapy drugs	Antiarrhythmics, class i and iii	Antiarrhythmics, class iii	Amiodarone	false	null	null	true	71
EC:00073	Amisulpride	CHEBI:64045	DB06288	[]	[]	Dopamine antagonist	Gastrointestinal; Central nervous system	Antiemetic \| Antipsychotic	Dopamine antagonist	APPROVED	true	false	false	false	false	false	false	false	false	N05AL05	N	N05	N05A	N05AL	N05AL05	Nervous system drugs	Psycholeptics	Antipsychotics	Benzamide antipsychotics	Amisulpride	false	null	null	false	72
EC:00074	Amitriptyline	CHEBI:2666	DB00321	[ "Amitriptyline hydrochloride" ]	[]	Tricyclic antidepressant	Central nervous system	Antidepressant	Serotonin and norepinephrine reuptake inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	N06AA09	N	N06	N06A	N06AA	N06AA09	Nervous system drugs	Psychoanaleptics	Antidepressants	Non-selective monoamine reuptake inhibitors	Amitriptyline	false	null	null	true	73
EC:00075	Amivantamab	UNII:0JSR7Z0NB6	DB16695	[]	[]	Anti-EGFR, Anti-MET bispecific antibody	Targeted cancer therapy	Monoclonal antibody therapy	Anti-EGFR, Anti-MET	APPROVED	false	false	false	false	false	false	false	false	false	L01FX18	L	L01	L01F	L01FX	L01FX18	Antineoplastic and immunomodulating agents	Antineoplastic agents	Monoclonal antibodies and antibody drug conjugates	Other monoclonal antibodies and antibody drug conjugates in atc	Amivantamab	false	null	null	false	74
EC:00076	Amlodipine	CHEBI:2668	DB00381	[]	[]	Dihydropyridine calcium channel blocker	Cardiovascular	Antihypertensive	calcium channel antagonist	APPROVED	false	false	false	false	false	false	false	true	false	C08CA01	C	C08	C08C	C08CA	C08CA01	Cardiovascular system drugs	Calcium channel blockers	Selective calcium channel blockers with mainly vascular effects	Dihydropyridine derivative selective calcium channel blockers with mainly vascular effects	Amlodipine	false	null	null	true	75
EC:00077	Ammonium lactate	RXCUI:2646433	DB06768	[]	[]	Keratolytic	Dermatology	Skin protector	Chemical exfoliant and hydrator	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	76
EC:00078	Amobarbital	CHEBI:2673	DB01351	[]	[]	Barbiturate	Central nervous system	Sedative	Barbiturate	NOT_APPROVED	false	true	false	false	false	false	false	false	false	N05CA02	N	N05	N05C	N05CA	N05CA02	Nervous system drugs	Psycholeptics	Hypnotics and sedatives	Barbiturates, hypnotics and sedatives, plain	Amobarbital	false	null	null	false	77
EC:00079	Amorolfine	CHEBI:599440	DB09056	[ "Amorolfin" ]	[]	Topical antifungal	Antimicrobial; Dermatology	Antifungal	Ergosterol synthesis inhibitor	NOT_APPROVED	false	false	true	false	false	false	false	false	false	D01AE16	D	D01	D01A	D01AE	D01AE16	Dermatologicals	Antifungals for dermatological use	Antifungals for topical use	Other antifungals for topical use in atc	Amorolfine	false	null	null	false	78
EC:00080	Amoxapine	CHEBI:2675	DB00543	[]	[]	Tricyclic antidepressant	Central nervous system	Antidepressant	Tricyclic antidepressant	APPROVED	false	false	false	false	false	false	false	false	false	N06AA17	N	N06	N06A	N06AA	N06AA17	Nervous system drugs	Psychoanaleptics	Antidepressants	Non-selective monoamine reuptake inhibitors	Amoxapine	false	null	null	true	79
EC:00081	Amoxicillin	CHEBI:2676	DB01060	[]	[]	Penicillin	Antimicrobial	Antibiotic	Penicillin	APPROVED	false	false	true	false	false	false	false	false	false	J01CA04	J	J01	J01C	J01CA	J01CA04	Antiinfectives for systemic use	Antibacterials for systemic use	Beta-lactam antibacterials, penicillins	Penicillins with extended spectrum	Amoxicillin	false	null	null	true	80
EC:00082	Amphetamine	CHEBI:132233	DB00182	[]	[]	Amphetamine and derivatives	Central nervous system	CNS Stimulant	centrally acting sympathomimetics	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	true	81
EC:00083	Amphotericin b	CHEBI:2682	DB00681	[]	[]	Polyene antifungal	Antimicrobial	Antifungal	Binds ergosterol	APPROVED	false	false	true	false	false	false	false	false	false	J02AA01	J	J02	J02A	J02AA	J02AA01	Antiinfectives for systemic use	Antimycotics for systemic use	Antimycotics for systemic use	Antibiotics for systemic use	Amphotericin b	false	null	null	true	82
EC:00084	Ampicillin	CHEBI:28971	DB00415	[]	[]	Penicillin	Antimicrobial	Antibiotic	Penicillin	APPROVED	false	false	true	false	false	false	false	false	false	J01CA01	J	J01	J01C	J01CA	J01CA01	Antiinfectives for systemic use	Antibacterials for systemic use	Beta-lactam antibacterials, penicillins	Penicillins with extended spectrum	Ampicillin	false	null	null	true	83
EC:00085	Amsacrine	CHEBI:2687	DB00276	[]	[]	Topoisomerase II inhibitor	Traditional cancer therapy	Topoisomerase inhibitor	Topoisomerase II inhibitor	NOT_APPROVED	false	false	false	false	true	false	false	false	false	L01XX01	L	L01	L01X	L01XX	L01XX01	Antineoplastic and immunomodulating agents	Antineoplastic agents	Other antineoplastic agents in atc	Other antineoplastic agents in atc	Amsacrine	false	null	null	false	84
EC:00086	Anagrelide	CHEBI:142290	DB00261	[]	[]	PDE-3 inhibitor	Hematology	Antiplatelet	PDE-3 inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L01XX35	L	L01	L01X	L01XX	L01XX35	Antineoplastic and immunomodulating agents	Antineoplastic agents	Other antineoplastic agents in atc	Other antineoplastic agents in atc	Anagrelide	false	null	null	true	85
EC:00087	Anakinra	UNII:9013DUQ28K	DB00026	[]	[]	IL-1 pathway inhibitor	Immune	Cytokine therapy	IL-1 receptor antagonist	APPROVED	false	false	false	false	false	false	false	false	false	L04AC03	L	L04	L04A	L04AC	L04AC03	Antineoplastic and immunomodulating agents	Immunosuppressants	Immunosuppressants	Interleukin inhibitors	Anakinra	false	null	null	false	86
EC:00088	Anastrozole	CHEBI:2704	DB01217	[]	[]	Aromatase inhibitor	Targeted cancer therapy	Hormonal chemotherapy	Aromatase inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L02BG03	L	L02	L02B	L02BG	L02BG03	Antineoplastic and immunomodulating agents	Endocrine therapy antineoplastic and immunomodulating agents	Hormone antagonists and related agents	Aromatase inhibitors	Anastrozole	false	null	null	true	87
EC:00089	Angiotensin ii	CHEBI:2719	DB11842	[ "Synthetic angiotensin ii", "Angiotensin ii (human)" ]	[]	Angiotensin II	Cardiovascular	Vasoactive Agent	Peptide hormone analog	APPROVED	false	false	false	false	false	false	false	true	false	C01CX09	C	C01	C01C	C01CX	C01CX09	Cardiovascular system drugs	Cardiac therapy drugs	Cardiac stimulants excl. cardiac glycosides	Other cardiac stimulants in atc	Angiotensin ii	false	null	null	true	88
EC:00090	Anidulafungin	CHEBI:55346	DB00362	[]	[]	Echinocandin antifungal	Antimicrobial	Antifungal	Beta-glucan synthesis inhibitor	APPROVED	false	false	true	false	false	false	false	false	false	J02AX06	J	J02	J02A	J02AX	J02AX06	Antiinfectives for systemic use	Antimycotics for systemic use	Antimycotics for systemic use	Other antimycotics for systemic use in atc	Anidulafungin	false	null	null	false	89
EC:00091	Anifrolumab	UNII:38RL9AE51Q	DB11976	[]	[]	IFNAR inhibitor	Immune	Antiinflammatory	IFNAR inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L04AG11	L	L04	L04A	L04AG	L04AG11	Antineoplastic and immunomodulating agents	Immunosuppressants	Immunosuppressants	Monoclonal antibodies	Anifrolumab	false	null	null	false	90
EC:00092	Ansuvimab	UNII:TG8IQ19NG2	DB16385	[]	[]	Anti-ebola antibody	Antimicrobial	Antiviral	Ebola	APPROVED	false	false	true	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	91
EC:00093	Anthralin	CHEBI:37510	DB11157	[ "Dithranol" ]	[]	Keratolytic	Dermatology	Inhibit keratinocyte proliferation	null	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	92
EC:00094	Anti-d immunoglobulin	UMLS:C5192004	DB11597	[ "Human rho(d) immune globulin", "Anti-d (rh0) immunoglobulin" ]	[]	Anti-D immunoglobulin	Hematology	Immunomodulator	Anti-D immunoglobulin	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	93
EC:00095	Antithrombin alfa	UMLS:C2316217	DB11166	[ "Antithrombin", "Antithrombin iii human", "Antithrombin iii" ]	[]	Antithrombin replacement	Hematology	Anticoagulant	Antithrombin replacement	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	94
EC:00096	Apadamtase alfa	UMLS:C4547518	DB15164	[ "Adamts13" ]	[]	ADAMTS13 replacement	Hematology	Thrombolytic	Recombinant human ADAMTS13	APPROVED	false	false	false	false	false	false	false	false	false	null	null	null	null	null	null	null	null	null	null	null	false	null	null	false	95
EC:00097	Apalutamide	UNII:4T36H88UA7	DB11901	[]	[]	Androgen receptor inhibitor	Targeted cancer therapy	Hormonal chemotherapy	Androgen receptor inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	L02BB05	L	L02	L02B	L02BB	L02BB05	Antineoplastic and immunomodulating agents	Endocrine therapy antineoplastic and immunomodulating agents	Hormone antagonists and related agents	Anti-androgen hormone antagonists and related agents	Apalutamide	false	null	null	true	96
EC:00098	Apixaban	CHEBI:72296	DB06605	[]	[]	Direct oral factor Xa inhibitor	Hematology	Anticoagulant	Direct oral factor Xa inhibitor	APPROVED	false	false	false	false	false	false	false	false	false	B01AF02	B	B01	B01A	B01AF	B01AF02	Blood and blood forming organ drugs	Antithrombotic agents	Antithrombotic agents	Direct factor xa inhibitors	Apixaban	false	null	null	true	97
EC:00099	Apomorphine	CHEBI:48538	DB00714	[ "Apomorphine hydrochloride" ]	[]	Dopamine agonist	Central nervous system	Antiparkinson	Dopamine agonist	APPROVED	false	false	false	false	false	false	false	false	false	N04BC07	N	N04	N04B	N04BC	N04BC07	Nervous system drugs	Anti-parkinson drugs	Dopaminergic agents	Dopamine agonists	Apomorphine	false	null	null	true	98
EC:00100	Apraclonidine	CHEBI:2788	DB00964	[]	[]	Alpha-adrenergic agonist	Ophthalmic	Reduce IOP \| decrease aqueous humor production	Alpha-2 agonist	APPROVED	false	false	false	false	false	false	false	false	false	S01EA03	S	S01	S01E	S01EA	S01EA03	Sensory organ drugs	Ophthalmologicals	Antiglaucoma preparations and miotics	Sympathomimetics in glaucoma therapy	Apraclonidine	false	null	null	true	99

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Dataset Card for Every Cure Drug List

Dataset Summary

The Every Cure Drug List is a manually curated list of drug entities used by the MATRIX project for drug repurposing predictions. For reference, the list contains ~1,800 drugs with metadata including approval status, drug class flags, therapeutic annotations, and ATC classifications.

For more information see here.

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