accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q4L3F2
ISPE_STAHJ
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Staphylococcus
MIYETAPAKINLTLDTLFKRDDGYHEIAMIMTTVDLNDRLSFQKRKDKKIVVDIEHNYVPNDHKNLAYRAAQLMMETYDLNEGVTITIDKDIPVSAGLAGGSADAAATMRGINRLFNLDKSLHELSDLGIQIGTDIPFCIYNRTAVCKGRGEKIRFLKKPPSAWVVLAKPNLGISSADVFKALDLDDAHHVDTEMCEKAIVEGDYKQLCESLSNRLEPVSMSMHPEIKKIKNNMLQCGADGALMSGSGPTVYGLAQKESQAKKIYNAVNGCCNEVYLVRLLG
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Q4L3F2
Q0I476
PROQ_HAES1
RNA chaperone ProQ
Histophilus
MTEIQKLTNNKEIIAYLAEKFPLCFSLEGEAKPLKIGLFQDLAEALANDEKVSKTQLRQALRQYTSNWRYLHGCRAGAVRVDLNGEPAGILEQEHVEHAAAKLAEAKAKVAERRAVEKANNPKANKKRSVYHSGNKSENKKSAGKKFSKPRQVEQIFVNVDLANLQKGDVVRVKAGDKTTKAEILEVVKEGARVELENGLILTVSADRLFA
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.
Q0I476
B8J832
RL20_ANAD2
50S ribosomal protein L20
Anaeromyxobacter
MRVKKGFKARRRRNRVLKLAKGFRGRRKNCYRRANQAVERALNYSTRDRRLKRREFRALWIVRINAAARQNGTTYSKLVAALRKAGIEIDRKILADLALALPGDFAAIVKTAQA
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
B8J832
B7LT80
TRHO_ESCF3
tRNA hydroxylation protein O
Escherichia
MPVLHNRISNDALKAKMLAENEPRTTISFYKYFTIADPQTTRDALYKLFTALNVFGRVYLAHEGINAQISVPESHVDKFRQQLYSFDPALNNLRLNIALDDDGKSFWVLRMKVRERIVADGITDPDFDASNVGNYLQAAQVNAMLDDPDALFIDMRNHYEYEVGHFENAMEIPADTFREQLPKAVEMMQEHKDKKIVMYCTGGIRCEKASAWMKHNGFEKVWHIEGGIIEYARKAREQGLPVRFIGKNFVFDERMGERISEDVIAHCHQCGTPCDSHTNCKNDGCHLLFIQCPVCAEKFNGCCSELCCTESALPPEEQRRLRAGRENGNKIFNKSRGRLNTQQGIPELKI
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
B7LT80
B3MSP2
EI3G2_DROAN
Eukaryotic translation initiation factor 3 subunit 4-2
Sophophora
MKPFKTSWADEVEADYVDGLPPCSEYIEGDYKYVTEYKFNDDGKKVKVVRTFKIEKQVVSKAVARRRGWVKFGDSRLDKPGPNSQTTMASEEIFMLFMGSKEFEQTHETQMDAGKNIAKCRICNGEHWSVNCPYKGTSMDSKTLMESKANAAAAAALNDPSKPGKYVPPFMKDGAGGAGGKGRERDDSSAVRISNLSESMTETDLEELVKKIGPHTKMYLAREKNTGLCKGFAYVHFKFRQDAAAAIEILNGHGYDHLILCVEWSKPQP
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
B3MSP2
B2KBN0
DEOC_ELUMP
Phosphodeoxyriboaldolase
Elusimicrobium
MNKTAKLIDHTLLKPGATEFEIKTLCAEALKYGFASVCVNPFWVKLAASELEGSDVKVCTVIGFPLGANTTEAKVFEAKNALENGAQELDMVINIGAVKSGLYELAYHDIKLIRDLGKNFVLKVILETTLLTDAEKIKVCELSACAEADFVKTSTGFAGGGATIEDVKLMKANISSGMQVKASGGVRDLETLTKMVEAGASRIGTSSSIKIIESL
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
B2KBN0
P59493
DEF_BUCBP
Polypeptide deformylase
Buchnera
MSVLKILKYPDDRLRIIAKPISKIDTKIHNIIINMFDTMYYENGIGLAATQVNIPLQIIVIDKIEELNHPLVLINPKITKRSGLTSIQEGCLSIPNYQAEISRSKKITVTALNYFGKRIKLKTSSTLSICIQHEIDHLIGKLLIDYLSNLTNLKLLKKNK
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
P59493
Q6C922
YTH1_YARLI
null
Yarrowia
MKFETPSRFKFTPYLEREYQFGLDPNRPLCRGFLQFDGCPRGNSCPDKHLAPTFLNKIVCKHWLRGLCKKGLNCEFLHEYNLQKMPECQFYVKNGFCTQSPDCQYLHIDPASKIPVCFNYEKGFCKMGPECSRKHIRRMPCELYMTGFCPKGRVCEFAHPKFVGIYDYMIIKPNPKDKAKDETKQETKEEALQ
Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.
Q6C922
Q94ID2
IPT5_ARATH
Cytokinin synthase 5
Arabidopsis
MKPCMTALRQVIQPLSLNFQGNMVDVPFFRRKDKVVFVMGATGTGKSRLAIDLATRFPAEIVNSDKIQVYKGLDIVTNKVTPEESLGVPHHLLGTVHDTYEDFTAEDFQREAIRAVESIVQRDRVPIIAGGSNSYIEALVNDCVDFRLRYNCCFLWVDVSRPVLHSFVSERVDKMVDMGLVDEVRRIFDPSSSDYSAGIRRAIGVPELDEFLRSEMRNYPAETTERLLETAIEKIKENTCLLACRQLQKIQRLYKQWKWNMHRVDATEVFLRRGEEADEAWDNSVAHPSALAVEKFLSYSDDHHLEGANILLPEISAVPPLPAAVAAISR
Involved in cytokinin biosynthesis. Catalyzes the transfer of an isopentenyl group from dimethylallyl diphosphate (DMAPP) to ATP and ADP.
Q94ID2
Q805B2
FGF8B_DANRE
Fibroblast growth factor 17a
Danio
MRLKSSRLGYLFLQFMTLCFYTQMTMQSISMPNFKHHVTEQSRLSDRMSRRLTRTYQLYSRTSGKHVQVLGNKRVNANAEDGDIHAKLVVETDTFGSRVRIRGAKTGYYICMNKKGKLIGRRKGRGKDCIFTEIVLENNYTALQNAKYKGWYMAFTRKGRPRKAMQTRQHQREAHFMKRLPRGHLLTEQKPFDLIPYPLNKRTKHHQRASVN
May act as signaling molecule during development of the midbrain-hindbrain boundary (MHB) organizer, and be involved in patterning of the nervous system.
Q805B2
A7ZHZ2
DPO4_ECO24
DNA polymerase IV
Escherichia
MRKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGSRERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVTDSVHCHGSATLIAQEIRQTIFSELQLTASAGVAPVKFLAKIASDMNKPNGQFVITPAEVPAFLQTLPLAKIPGVGKVSAAKLEAMGLRTCGDVQKCDLVMLLKRFGKFGRILWERSQGIDERDVNSERLRKSVGVERTMAEDIHHWSECEAIIERLYPELERRLAKVKPDLLIARQGVKLKFDDFQQTTQEHVWPRLNKADLIATARKTWDERRGGRGVRLVGLHVTLLDPQMERQLVLGL
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
A7ZHZ2
B5FSN3
RUVC_SALDC
Holliday junction resolvase RuvC
Salmonella
MSIILGIDPGSRITGYGVIRQVGRQLTYLGSGCIRTKVDDLPSRLKLIYAGVTEIITQFQPDYFAIEQVFMAKNADSALKLGQARGVAIVAAVNQELPVFEYAARQVKQTVVGIGSAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNAMQMSESRLNLARGRMR
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
B5FSN3
Q8HVU9
NDHI_CHAST
NADH-plastoquinone oxidoreductase subunit I
Chaenactis
MFPMVTEFMNYGQQTVRATRYIGQGFMITLSHANRLPVTVQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPMSIIDDYTIRTILNLPEIKT
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Q8HVU9
Q5KWC8
NRDR_GEOKA
Transcriptional repressor NrdR
Geobacillus thermoleovorans group
MRCPSCHHSGTRVLESRPVEEGRSIRRRRECEQCHYRFTTFERIEEPPLIVVKKEGTREEFSREKILRGLIKACEKRPVALEELEKVTQEIERELRNQGVSEVKSETIGEMVMERLSHIDEVAYVRFASVYRQFKDINVFIEELKELIKKGQR
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
Q5KWC8
P53456
ACT2_DIBDE
Actin-2
Dibothriocephalus
MGDEEVQALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTRIMFETFNTPAMYVGIQAVLSLYASGRTTGIVLDSGDGVTHSVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSYELPDGQVITIGNERFRCPESLFQPSFLGMESAGIHESTFNAIMKCDVDIRKDLYANTVLSGGTTMYPGIADRMQKEITSLAPSTMKIKIVAPPERKYSVWIGGSILASLSTFQQMWISKQEYDESGPGIVHRKCF
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
P53456
A6LSQ9
RS15_CLOB8
30S ribosomal protein S15
Clostridium
MDKARKLELIKKFGRSEGDTGSPEVQVALLTERIQSLTEHLKVHKKDHHSRRGLLMMVGQRRGLLNYLSDQDIERYRTLIKELGLRR
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
A6LSQ9
Q5LNP1
ATPB_RUEPO
F-ATPase subunit beta
Ruegeria
MANAKGKVTQIIGAVVDVQFDDALPEILNALETENNGKRLVLEVAQHLGENTVRTIAMDATEGLVRGAVVTDTGGPISVPVGAATLGRILNVIGEPVDEKGPVNATETRAIHQPAPSFDEQSTSSDILVTGIKVIDLLAPYSKGGKIGLFGGAGVGKTVLIMELINNIAKVHSGYSVFAGVGERTREGNDLYHEMIESNVIKLENLEESQVALVYGQMNEPPGARARVALTGLTLAEQFRDQSGTDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGAMQERITSTKAGSITSIQAVYVPADDLTDPAPATTFAHLDATTVLSRAISELGIYPAVDPLDSSSRILDPQVVGEEHYQVARDVQGILQRYKSLQDIIAILGMDELSEEDKLTVARARKIQRFLSQPFDVAKVFTGSDGVQVPLEDTISSFKAVVAGEYDHLPEGAFYMVGGIDEVIAKAERMAAEAA
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q5LNP1
Q7ZZN8
CRVP2_NAJAT
Protein G2b
Naja
MIAFIVLLSLAAVLQQSSGTVDFASESSNKRENQKQIVDKHNALRRSVRPTARNMLQMEWNSNAAQNAKRWADRCSFAHSPPHLRTVGKIGCGENLFMSSQPYAWSRVIQSWYDENKKFVYGVGANPPGSVIGHYTQIVWYNSHLLGCGAAKCSSSKYLYVCQYCPTGNIIGSIATPYKSGPPCGDCPSACVNGLCTNPCKHHNVFSNCQSLAKQNACQTEWMKSKCAASCFCRTEII
Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.
Q7ZZN8
Q9RWN1
PFKA_DEIRA
Phosphohexokinase
Deinococcus
MAYPNPAGIKRVAVLTSGGDAPGMNAAIRAVVRTGAQQGIEVVGVRRGFSGLHRGEVQLLGPRDVANTIQRGGTILLTARSHTWRSPEGRAKGAAVLREWGVDGLVVIGGDGSFHGGYFLQEEHGIPVIGVPGTIDNDLYGTDHTIGYFTAVETALEAVDKLRDTGASHERIFVIEVMGRHAGHIALDVAVAGGAEEVFIPEDKKPIGDVVNIVKDSIAKGKRGSIIIVAEGYDGGAEAVAQAIHAGTGLETRVSILGHIQRGGTPVSSDRILASRLGEAAVYALMDGKKGVMVGRIGGGIAYTPLHETWEKRKDVSRDLYRCAKMLSI
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Q9RWN1
A4IJ95
PDXT_GEOTN
Pyridoxal 5'-phosphate synthase glutaminase subunit
Geobacillus
MKIGVLGLQGAVQEHVRAIEACGAEAVVVKKTEQLTGLDGLVLPGGESTTMRRLIDRYGLMEPLKQFAADGKPMFGTCAGLILLAKRIVGYDEPHLGLMDITVERNSFGRQRESFEAELSIKGVGDGFVGVFIRAPHIVEVGDEVEVLATYNDRIVAARQGQFLGCSFHPELTDDHRLMRYFLNMVKEAKTVSSI
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
A4IJ95
Q92EU3
DHAL2_LISIN
PEP-dependent dihydroxyacetone kinase 2, ADP-binding subunit DhaL
Listeria
MSELVMDSAFFGHVLQDMGALIEKERDYLTGLDSDIGDGDHGINLSIGFREVNKQLDELLTVSPDIATLLKKSGMILLGKVGGASGPLYGSFFMKCGADVPGKTEVNFDELCGMIINGAAAVQHRGKAELGDKTMMDAFLPGVEVLQNRDTNADPIETFSAFVDAMHAGAQSTIPLIAKKGRALRLGERAIGHLDPGSESSWMLMNVILENLKKAV
ADP-binding subunit of the dihydroxyacetone kinase, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaL-ADP is converted to DhaL-ATP via a phosphoryl group transfer from DhaM and transmits it to dihydroxyacetone binds to DhaK.
Q92EU3
Q96V54
CREB_EMENI
Ubiquitin-specific-processing protease creB
Aspergillus subgen. Nidulantes
MGSFLKSFRKDVGSAAPSVGAPPAKKEPQPLPMTPLEKMLTELGPIRGDGSDKFYGMENFGNTCYCNSILQCLYYSVPFREAVLNYPKRTPIEDLEAALAKALRYQDPNARLEAEALAEKQKAANSPRPGQPPNPQQKPEDKDSPEYKKKLALQTLPLLETTDNSVSYGIPESLFSSLKDMFESIVGSQSRIGIIRPQHFLEVLRRENEMFRTAMHQDAHEFLNLLLNEVVVDVEKAAAKLLESPQPASDVSDSVIPSSSSGSRTPNTTRWVHELFEGLLTSETQCLTCEKASQRDEVFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVSIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGDKPGLACAYVLFYQETTMEAVMKEQEQENTEPPVEVNASTLKQNGFSSSATLAHAHSASQVPTYEDHDRFTGLKRAPTAPQLSTHPEHTTTDSESLPSPAPDPAPLTSLPPIPPIPETPPAPLTSRKSDLQSKKERVKEEKERKAAEKEKEKQRRKEIETRLKDRQRREDDDLKAALEASKVSKEDEDRRNHAENGTSKKNAGGLGRFRSLSQRLSTKESRTSLSRIPPLPNGNHTLSKVPDESEQTHPKSPTPPAPLSRPASQPLNDDLLGSPRADTLAVPTEQEHIKNSKHDRSSHGKWRSFSLRKKSFNILSS
Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.
Q96V54
Q3SRY6
RL9_NITWN
50S ribosomal protein L9
Nitrobacter
MEIILLERVAKLGQMGEVVKVKDGFARNFLLRRGKALRATAENRAKYDGMKAELEANNIKAKGEAATVAEKINGRDIVVIRQASETGQLFGSVTVRDIVAALAADGIIVSRPQVWLDAPIKTIGQQKLTVAVHPEVEAEITVTVARSVDEAERIQRGEDISTRREDRDAAAEAIAAAGEFFDPDAQHDDEPAAEDDQNAEEK
Binds to the 23S rRNA.
Q3SRY6
A0KPE4
DEOC_AERHH
Phosphodeoxyriboaldolase
Aeromonas
MTDLKLAAQRALNLMDLTTLNDDDTDQKVIDLCRKAKSPAGLTAAVCIYPRFIPIARKTLREIGAADVRIATVTNFPHGNDDIEIAVAETRAAVAYGADEVDVVFPYRAFMAGNEQVGFDLVKACKEACGSQALLKVIIETGELKEEALIRRASEISIDAGADFIKTSTGKVPVNATPEAARIMMEVIKAKNPKVGFKPAGGVKDAAVAGQYLAMAEEILGKDWVSARTFRFGASSLLASLLATLGHGDKPANTSGY
Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.
A0KPE4
A6TFL4
HLDD_KLEP7
ADP-L-glycero-beta-D-manno-heptose-6-epimerase
Klebsiella
MIIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGTKFVNLVDLNIADYMDKEDFLIQIMAGEEFGEIEAIFHEGACSSTTEWDGKYMMDNNYQYSKELLHYCLEREIPFLYASSAATYGGRTSDFIESREYEQPLNVYGYSKFLFDEYVRQILPEANSQIVGFRYFNVYGPREGHKGSMASVAFHLNTQLNNGESPKLFEGSDGFKRDFVYVGDVADVNLWFWENGVSGIFNLGTGRAESFQAVADATLAYHKKGSIEYIPFPDKLKGRYQAFTQADLTNLRKAGYDKPFKTVAEGVTEYMAWLNRDA
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
A6TFL4
Q7VD77
PURA_PROMA
IMP--aspartate ligase
Prochlorococcus
MANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTIVVDEKVLKLHLIPSGILYPETICLIGSGTVVDPKVMLKEIKMLKDNDIDISGLQLASTAHVTMPYHCVIDAAMEERRGLKKIGTTGRGIGPTYADKSQRNGIRVIDLLDERKLREALEIPLAEKNELLEKIYGKEAIDKEKIIEEYLEFGRLIKPHVVDCTRIIHKASRNKKNILFEGAQGTLLDLDHGTYPFVTSSNPVSGGACIGAGVGPTLIDRVIGVAKAYTTRVGEGPFPTELKGKINDQLCDRGGEYGTTTGRRRRCGWFDGVIGKYAVEVNGLDCLAITKLDVLDELEEIKVCTSYELNGEKIDYFPSSAEDFGKCTPIFKTLPGWKSSTANCRHLEDLPPPAMAYLRFLAELMEVPIAIVSLGASRDQTIVVEDPIHGPKRALLSS
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q7VD77
Q7NBP5
SYP_MYCGA
Prolyl-tRNA synthetase
Mycoplasma
MAFKKNLASSKDDNISDWYTEVISKGNLIHYSNIKGFMSFLPNGWKIWQLIKKELTKEFDQRDILELCLPSLISQNDFLLEKKHLEGFAPELFIVTKTSNETEKYILRPTSEIAFCNLWRETLRNYRQLPIKHNQWTSVFRVEKNTRPFLRNSEFFWHEIHSCFETEEQSNDFAVDIWKLYQRFIKDILCIPLVAGEKTEAEKFAGAKTTYTVETIMPDGQALQSATSHNLSQNFSKAFDIRYQTKNNDYQNVFSMSAGVSTRIIGAIIMTHGDDDGLVFPTKVAPYHISLNCIFDDTNQELNAKLKELANKYSQKYRVHLNVNKDSTGEIIKNSQLRGDCCVLLMGPNDLKKNEIVFIDRITKQKQFINLDHLDQKLEELFSTFDQKLYQKAKAVFETKVDFAQTFEEFEQKIASGKFVRVFYCNEDLYEKQIKEKTGASSRCIIKYLDEQTQERCFISNKKAKVEIYFARSY
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Q7NBP5
B2HCX3
RS4_MYCMM
30S ribosomal protein S4
Mycobacterium
MARYTGPVTRKSRRLGTDLVGGDQSFEKRPYPPGQHGRARIKDSEYRQQLQEKQKARFTYGVMEKQFRRYYEEAVRHSGKTGEELLKILESRLDNVVYRAGLARTRRMARQLVSHGHFSVNGVHVNVPSYRVSQYDIIDVRDNSLNTVPFQIARETAGDRPIPSWLQVVGERQRILIHQLPERAQIEVPLTEQLIVEYYSK
With S5 and S12 plays an important role in translational accuracy.
B2HCX3
Q6D2L6
FADI_PECAS
Fatty acid oxidation complex subunit beta
Pectobacterium
MSEVLPLITRRGDRIAFVSGLRTPFARQATAYHGVPAIELGKLVTSELLVRTGIDPELIELLVFGQVVQMPEAPNIAREIVLGTGMSVHTDAYSVSRACATSFQAVANVAESIMAGTVEVGIAGGADSSSVLPIGVSKALARTLVDMNKARTLGQKLRLLSGLRPKDLLPVAPAVAEYSTGLRMGDTAEQMAKTYGITREEQDELAHRSHKLAAQAWESGVLRDEVMTAYVPPYEKALSEDNNVRHDSAIEQYSRLRPAFDRRHGTVTAANSTPLTDGAAAVLMMSESKAKSLGLTPLGYLRSYAFSAIGVQRDMLLGPAYASPLALARAGVALADLTLIDMHEAFAAQTLANLKLFASDEFARNQLGRNAALGEVDRAKFNVLGGSIAYGHPFAATGARMITQTLNELRRRGGGLGLTTACAAGGLGAAMVLEVTP
Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Q6D2L6
Q0IDJ4
NU3C_SYNS3
NDH-1 subunit 3
unclassified Synechococcus
MVYECQTGVQIEAALMFVLPGYDAFLGFLLIAAAVPVLALVTNKLLAPRSQTGERELTYESGMEPIGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFHRLGLLAFIEALVFITILLVALAYAWRKGALEWS
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
Q0IDJ4
P12702
COX3_PARLI
Cytochrome c oxidase polypeptide III
Paracentrotus
MMAHQHPYYLVEQSPWPLTGAISGLMMNLGLVLWFHTGNIILLFTGLLLLILTLVNWWRDIVREATFQGSHTAIVENGLRYPMILFITSEVCFFFAFFWAFFHSSLAPAVEIGVTWPPSGITPLNPFLVPLLNTAVLLSSGVTITWSHHSILAGNRNEAIQALFLTVVLGIYFTILQAWEYIDAPFTIADSVYGSTFFVATGFHGLHVIIGTTFLLVCLIRLSGHHFSTHHHFGFEAAAWYWHFVDVVWLFLYVCIYWWGS
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
P12702
Q6BHL8
IPK1_DEBHA
Ins(1,3,4,5,6)P5 2-kinase
Debaryomyces
MEIYKITTPGEWTYFAKGNANILFKYTGSNDYLRHKLLRVRLLKEDEQYISTCELYDFIELKCKPLFPHQIIDIQLVVLTTDFVNQLNNEGNKLMVKERYGLLLPNILDGDYCKQFLSRNCQLYIGTDTTVQEAGVNRNTVPEKLQGQEQKKLQKQEQFNNDIDSVIFEIKPKWLYDNISSNYCRTCSLNQLRGFQRHFCPLDLLYEETIDQGLDDILSLIPQDLLIEISETNKIPVKQLFRIFLNNPNNVFQKLKEYQRINNKNDLIKNITSIYDVSQNLSLVMTLRDVGLFIKFEKYNKYNNIHNSHNNINNLINIEGYGKFLLTCNIYDLDLKSKLKYKHWLDTEEKLQSIYNSSNPDWRHCVKVHDNTNNLGT
Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.
Q6BHL8
B7JY20
ARGC_RIPO1
N-acetyl-glutamate semialdehyde dehydrogenase
Rippkaea orientalis
MGESERIPVGIIGASGYGGVQLVRLLLEHPQVEIAYLGGKGSAGKPYWDLYPHLSHLVNLTVEPIDLEVVASRCQVVFLGLPNGLACDMAPQLIAKGCKVLDLSADYRFRDLQTYTAWYNKDRSDTETAAKAVYGLPELYRTEIQSASLIGCPGCYPTASLMALSPLLKQGLILPETAIIDAKSGTSGGGRQEKIHLLLAEAEGSLGAYGVAKHRHTPEIEQVCSDLAGHEVKVQFTPHLIPMVRGILSTVYASLRDPGLVRDDILTIYSAFYRSSPFVKILPHGIYPQTKWAWGTNLCYIGIETDPRTDRVIVLSAIDNLMKGQAGQAVQCLNLMMGWEETLGLPQLSFYP
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
B7JY20
Q2K284
METN_RHIEC
Methionine import ATP-binding protein MetN
Rhizobium
MNSVVTRAAIEPRPQAAAEEVVRLIDVKRRFGATPALDGISLNVNRGEILGIIGRSGAGKSTLIRCLNGLERADSGEIRIEGRDITGLQEQELQPLRGRIGMIFQHFNLLSAKTVEDNVALPLKIEGIAKAERLQRAHELLEVVGLADKAQAYPASLSGGQKQRVGIARALAARPALLLSDEATSALDPETTRSILALLRDINRKLGLTILLITHEMEVVRGIADRVAVIDAGRIVEEGQVWSVFANPQTDITRSLLGGIRPQLPDHILSRLSATTGSEVILSVDLAGPEAQGALFAELSAALPHSFRLVHGGIDHIQNQPVARFFIAVPAHEPALAGKVEQFLTARSARVEVLGYDTGHA
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q2K284
Q1MFZ8
RECA_RHIL3
Recombinase A
Rhizobium
MSQNSLRLVEDKSVDKSKALEAALSQIERSFGKGSIMKLGSNENVVEIETISTGSLGLDIALGVGGLPRGRIIEIYGPESSGKTTLALQTIAEAQKKGGICAFVDAEHALDPVYARKLGVDLQNLLISQPDTGEQALEITDTLVRSGAVDVLVVDSVAALTPRAEIEGEMGDSLPGLQARLMSQALRKLTASISKSNTMVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRRIGAVKEREEVIGNQTRVKVVKNKMAPPFKQVEFDIMYGEGVSKTGELVDLGVKAGIVEKSGAWFSYNSQRLGQGRENAKTFLRDNPDLAREIELSLRQNAGLIADRFLQNGGPDPDDGDGDATAEM
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
Q1MFZ8
B1P1D3
JZT18_CHIGU
Jingzhaotoxin-18
Chilobrachys
MKTTILVVILGLTLLFALSAATELKDEERDCKGFQVKCKKDSECCSSYVCGRQWKWCVYPSPFGR
Probable ion channel inhibitor.
B1P1D3
Q330E5
NU2M_MORBE
NADH dehydrogenase subunit 2
Mormopterus
MNPLIMSIILATIILGTTIVMTGSHWLMIWIGFEMNMLAIIPMLMKQHNPRSTEAATKYFFTQATASMLLMLAGIINLMYSGQWTGVKLVNPTASIIMTLALAMKLGLAPFHFWVPEVTQGIPLSSGLILLTWQKLASMTGLYMISPGINLNMLMTMSMLSIAIGGWGGLNQTQLRKIMAYSSIAHMGWMTAILIYNPTMTLLNLVIYILMTTTMFMLFMINSSTTTLSLSHTWNKMPLITTTTLVTLLSMGGLPPLMGFLPKWMIIQEMTKNNNIVLPTIMAITALLNLFFYMRLTYATSLTMFPTTNNMKIKWQFENPKYLSLLTPMIMMSTLTLPLAPMMMILN
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Q330E5
Q18EY6
RS10_HALWD
30S ribosomal protein S10
Haloquadratum
MQQARVRLAGTSPDDLDDICDDVRDIADTTGVNLSGPIPLPTKTLEIPTRKSPDGEGTATWEHWEMRVHKRLIDIDADERALRQLMRIQVPNDVSIEIVLED
Involved in the binding of tRNA to the ribosomes.
Q18EY6
Q34952
CYB_LORTA
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Loris
MTNIRKTHPLTKIINHSFIDLPTPSNISSWWNFGSLLGLCLVIQIMTGLFLAMHYTPDTTTAFSSVTHICRDVNYGWMIRYLHANGASMFFMCLFIHIGRGIYYGSFTFLETWNIGIMLLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIITALTAIHLLFLHESGSNNPSGMTSDSDKIPFHPYYTLKDILGVIALLITLSTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALISSILILALMPFLNMAKQRSMMFRPLSQCLFWTLVANLMVLTWIGGQPVENPFIIIGQLASIMYFSTILIFMPLTNLLENKLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q34952
A4TDE5
RF2_MYCGI
Peptide chain release factor 2
Mycolicibacterium
MDPDRQSDIAALDTTLTTVERVVNVDGLRGRIQQLESDASDPKLWDDQARAQKVTSDLSHAQNELRRVEELRSRLDDLPVLYELAAEEEGAGSSEAFAEADAELAKLREDIAGMEVRTLLSGEYDEREALVNIRSGAGGVDAADWAEMLMRMYIRWAEQHDYPVEVFDTSYAEEAGIKSATFAVHAPYAYGNLSVEQGTHRLVRISPFDNQSRRQTSFADVEVLPVVETTDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPTGIVVTCQNEKSQLQNKVSAMRVLQAKLLERKRLEERAEMDALKGDGGSSWGNQMRSYVLHPYQMVKDLRTEYEVGNPAAVLDGDIDGFLEAGIRWRNQKVDDE
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
A4TDE5
P52643
LDHD_ECOLI
Fermentative lactate dehydrogenase
Escherichia
MKLAVYSTKQYDKKYLQQVNESFGFELEFFDFLLTEKTAKTANGCEAVCIFVNDDGSRPVLEELKKHGVKYIALRCAGFNNVDLDAAKELGLKVVRVPAYDPEAVAEHAIGMMMTLNRRIHRAYQRTRDANFSLEGLTGFTMYGKTAGVIGTGKIGVAMLRILKGFGMRLLAFDPYPSAAALELGVEYVDLPTLFSESDVISLHCPLTPENYHLLNEAAFEQMKNGVMIVNTSRGALIDSQAAIEALKNQKIGSLGMDVYENERDLFFEDKSNDVIQDDVFRRLSACHNVLFTGHQAFLTAEALTSISQTTLQNLSNLEKGETCPNELV
Fermentative lactate dehydrogenase.
P52643
Q2KE55
HSLV_RHIEC
ATP-dependent protease subunit HslV
Rhizobium
MTTIITVRKGGKVVMAGDGQVSLGQTVMKGNARKVRRIGKGDVIAGFAGATADAFTLLERLEKKLEQYPGQLMRAAVELAKDWRTDKYLRNLEAMMLVADKSITLAITGNGDVLEPEHGTTAIGSGGNFAFAAARALMDTDKPAEEIARRALDIAADICVYTNHNIVVELLDVES
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
Q2KE55
Q9CPA2
RBSR_PASMU
Ribose operon repressor
Pasteurella
MATMKDIARIAKVSTSTVSHVINNSRFVSDEIRDKVMHVVKELNYTPSALARSLKVKETKTIGLLVTATNNPFFTEVVSGVEQYCHQHHYNLILSNTEGDTERLRHNLQTLIQKQVDGLLLMCSDARIQIGKDLNVNLPFVVMDWWPTEEKADKIYENSEYGGYLATKQLIEKGHQHIAIITGNLKKSLAQNRLDGYKKALKEANIPLREDCIIESHFDFEGGKRGMEKVLALQPRPTAVFACSDSIAFGAYQTVWHQGLHIPQDISIIGYDNITLAEYMSPPLTTINQPKAELGKLAVETLLQRIKNPTAKHRTLLLEPQLVWRESVRQLYQEKRG
Transcriptional repressor for the ribose rbsDACBK operon.
Q9CPA2
A2WXR5
ALFL6_ORYSI
PHD finger protein ALFIN-LIKE 6
Oryza sativa
MEGGGGGGGGGGGGGGGGGGGGAPYATRTAEEVFRDLRGRRAGMIKALTTDVEKFYKLCDPEKENLCLYGYPNETWEVTLPAEEVPPEIPEPALGINFARDGMNEKDWLALVAVHSDSWLLSVAFYFGARFGFDREARRRLFNMINNLPTIFEVVTGAAKKQAKEKTPNSSSKSNKPSSKVQSKAESRSKSKLSAPKDEEGSGDDEGEEEEDDHDNTLCGTCGTNDGKDEFWICCDNCEKWYHGKCVKITPARAEHIKQYKCPDCTNKRTRA
Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.
A2WXR5
Q93705
UNC3_CAEEL
Uncoordinated protein 3
Caenorhabditis
MSLTAPLRAGQMNFYDEPYNPVLNLHIQPSVKDENQRSTWPIIDTSNTSTQIARAHFEKHPPNNLRKSNFFHFVIALYDRNSQPIEVERTQFAGFVEKEKEVDGQDTRNGIHYRLSLMFQNGIRSEHDLFVRLIDSSTKQAITYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVLCSSARIDGPLLAVSDNMFVHNNSKHGRRTKRTDASDDSEYSESAELPSSVPVIKALFPSEGWIQGGTQVVLIGENFFEGLQVAFGTASPNWGESVQLISPHAIRVTTPPKHSAGPVDVTLQYKSKTYSRGTPLRFSYITLAEPGIEYGFQRLQKLLPKYPGDPERLPKDQILKRAAELAEALYNRTSTESLSSYYHTQFDATSDYAARTHTSPRSTLPYGAGPPALSSAVYQTSYPTVNATPAANFLNTQTGFATFGAVNPFAATLQSSSRLS
Transcription factor . Involved in motor neuron fate determination and maintenance, acting as an activator of gene expression in a subset of motor neurons . May act in concert with GFI1 homolog pag-3 in motor neuron fate determination . Required to maintain the expression of transcriptional repressors bnc-1 and cfi-1, which play roles in the cell fate of motor neurons . May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons . Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development .
Q93705
A4Y732
AROA_SHEPC
5-enolpyruvylshikimate-3-phosphate synthase
Shewanella
MKQLRLEPVVQVRGEINIPGSKSISNRALLLATLAQGTTTLTNLLDSDDIRHMLASLKQLGVNYRLSQNNTVCELDGIGGVISSASAQELFLGNAGTAMRPLCAALTLGQGEFTLTGEPRMEERPIGDLVDALRQLGANIVYLKNDGFPPLTINATGLNGGDVEIAGDLSSQFLTALLMVAPLAKGSVNIHVKGELVSKPYIDITIALMAQFGVNVINHDYARFEIVAGQRYISPGKVLVEGDASSASYFLAAGAIKGGEVKVTGVGRLSIQGDVKFADVLEKMGADIEWGDDYIIARGSPLTAVDLDMNHIPDAAMTIATAALFAKGTTVIRNIYNWRIKETDRLAAMATELRKVGAEVEEGNDYIKITPPAVINTAEIDTYNDHRMAMCFSMLAFADCGITINDPDCTSKTFPDYFKQFASLQG
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
A4Y732
A5VJ33
MURG_LIMRD
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Limosilactobacillus
MRLLVSGGGTGGHIYPALALIERLKQVEPDTEVLYVGTTRGLENKIVPDAGIELETMHMQGFKRSLSLENFKTIYLFLNSVHHAKKIISEFKPDVVLGTGGYVSGAVLYAAAKKHIPTVIHEQNSVVGVTNKFLSRYVDQIAIAFEAARSQFPADKVTMAGNPRAQQVAAKKDSDFSWTRYDLKDDVPTLMIFGGSQGAPKINKTVVDAIPEFNKRPYQVIFATGQKRYDDVKKQLAEGNIKPADNVKVVPYIKDMPAKMPRVAALVSRAGATTIAEVTALGVPTILIPSPYVTANHQVKNAQALVKNNAGLMITEDKLDARALLTQADKIMEDEEVRKEMAHAAEKMGRPDAADRLIKILHKAIDEHEK
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
A5VJ33
Q2W2J8
RL16_MAGSA
50S ribosomal protein L16
Magnetospirillum
MLSPKRTKFRKAHKGRIKGVTKGGSALNFGAYGLKALEPERITARQIEAARRALTRHMKRQGRVWIRIFPDLPVSSKPAEVRMGSGKGAPEFWTARVAPGRILFEVDGVAEEIARHGFALAAAKLPIKTKFISRIGDI
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q2W2J8
Q21691
NRDE3_CAEEL
Nuclear RNAi defective-3 protein
Caenorhabditis
MDLLDKVMGEMGSKPGSTAKKPATSASSTPRTNVWGTAKKPSSQQQPPKPLFTTPGSQQGSLGGRIPKREHTDRTGPDPKRKPLGGLSVPDSFNNFGTFRVQMNAWNLDISKMDERISRIMFRATLVHTDGRRFELSLGVSAFSGDVNRQQRRQAQCLLFRAWFKRNPELFKGMTDPAIAAYDAAETIYVGCSFFDVELTEHVCHLTEADFSPQEWKIVSLISRRSGSTFEIRIKTNPPIYTRGPNALTLENRSELTRIIEAITDQCLHNEKFLLYSSGTFPTKGGDIASPDEVTLIKSGFVKTTKIVDRDGVPDAIMTVDTTKSPFYKDTSLLKFFTAKMDQLTNSGGGPRGHNGGRERRDGGGNSRKYDDRRSPRDGEIDYDERTVSHYQRQFQDERISDGMLNTLKQSLKGLDCQPIHLKDSKANRSIMIDEIHTGTADSVTFEQKLPDGEMKLTSITEYYLQRYNYRLKFPHLPLVTSKRAKCYDFYPMELMSILPGQRIKQSHMTVDIQSYMTGKMSSLPDQHIKQSKLVLTEYLKLGDQPANRQMDAFRVSLKSIQPIVTNAHWLSPPDMKFANNQLYSLNPTRGVRFQTNGKFVMPARVKSVTIINYDKEFNRNVDMFAEGLAKHCSEQGMKFDSRPNSWKKVNLGSSDRRGTKVEIEEAIRNGVTIVFGIIAEKRPDMHDILKYFEEKLGQQTIQISSETADKFMRDHGGKQTIDNVIRKLNPKCGGTNFLIDVPESVGHRVVCNNSAEMRAKLYAKTQFIGFEMSHTGARTRFDIQKVMFDGDPTVVGVAYSLKHSAQLGGFSYFQESRLHKLTNLQEKMQICLNAYEQSSSYLPETVVVYRVGSGEGDYPQIVNEVNEMKLAARKKKHGYNPKFLVICTQRNSHIRVFPEHINERGKSMEQNVKSGTCVDVPGASHGYEEFILCCQTPLIGTVKPTKYTIIVNDCRWSKNEIMNVTYHLAFAHQVSYAPPAIPNVSYAAQNLAKRGHNNYKTHTKLVDMNDYSYRIKEKHEEIISSEEVDDILMRDFIETVSNDLNAMTINGRNFWA
Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei . Required for exogenous RNAi-induced H3K27 methylation .
Q21691
A0PT89
RECA_MYCUA
Recombinase A
Mycobacterium
MAQAPDREKALELAMAQIEKSYGKGSVMRLGDEVRQPISIIPTGSIALDVALGIGGLPRGRVIEIYGPESSGKTTVALHAVANAQAAGGVAAFIDAEHALDPEYAKKLGVDTDSLLVSQPDTGEQALEIVDMLIRSGALDIVVIDSVAALVPRAELEGEMGDSHVGLQARLMSQALRKMTGALNNSGTTAIFINQLRDKIGVMFGSPETTTGGKALKFYASVRMDVRRIETLKDGTNAVGNRTRVKIVKNKVSPPFKQAEFDILYGRGISREGSLIDMGVDQGFIRKSGAWFTYEGEQLGQGKENARNFLLENGGVANEIEKKIKEKLGIGAVVTDDGVLPAPVDF
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
A0PT89
Q88XX0
RL18_LACPL
50S ribosomal protein L18
Lactiplantibacillus
MISKPDKNKTRQRRHARVRGKISGTAERPRLNVYRSNKNIYAQVIDDVEGVTLASASTLDSEVKGNNKTEKAASVGEVVAKRAAEKKIVDVVFDRGGYLYHGRVQALAEAARENGLKF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q88XX0
P68064
HBB2_PANON
Hemoglobin beta-2 chain
Panthera
MGFLSAEEKGLVNGLWSKVNVDEVGGEALGRLLVVYPWTQRFFQSFGDLSSADAIMSNAKVKAHGKKVLNSFSDGLKNIDDLKGAFAKLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGHEFNPQVQAAFQKVVAGVAKALAHRYH
Involved in oxygen transport from the lung to the various peripheral tissues.
P68064
Q9PEN0
AOTC_XYLFA
N-acetyl-L-ornithine transcarbamylase
Xylella
MALKHFLNTQDWSCSELNALLTQARAFKHNKLGNGLKGKSIALVFFNASMRTRSSFELGAFQLGGHAIVLQPGKDAWPIEFDTGTVMEAETEEHICEVARVLGHYVDLIGVRAFPKFLDWTYDRQDIVLNGFAKYSPVPVINMETITHPCQELAHIMALQEHFGTTDLRGKKYVLTWTYHPKPLNTAVANSALTIATRLGMDVTLLCPTPDYVLDERYIDWAQQNIADTGSTFQVSHDIDNAYRGADVIYAKSWGALPFFGNWAMEKPIRDQYRHFIVDEAKMALTNNAVFSHCLPLRRNVKATDAVMDGPNCIAIHEAGNRLHVQKAIMAALASQ
Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N(2)-acetyl-L-ornithine to produce N(2)-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway. The enzyme has no activity with ornithine.
Q9PEN0
Q12746
PGA3_YEAST
Processing of GAS1 and ALP protein 3
Saccharomyces
MSKEDIEGTNILDEPVHGIYIPAALFVVGVAITTYMSGELKILWSLPILFMIIFVRAYSAYKRRRSLYPDRWTSLELEDQTIISKNTALYRFKLKTRLESLDIPAGHHVAVRVPIDGKQEVRYYNPISSKLESGYLDLVVKAYVDGKVSKYFAGLNSGDTVDFKGPIGTLNYEPNSSKHLGIVAGGSGITPVLQILNEIITVPEDLTKVSLLYANETENDILLKDELDEMAEKYPHFQVHYVVHYPSDRWTGDVGYITKDQMNRYLPEYSEDNRLLICGPDGMNNLALQYAKELGWKVNSTRSSGDDQVFVF
NADH-dependent cytochrome b5 reductase that reduces coenzyme Q6 at the plasma membrane and mediates lifespan extension by calorie restriction by shifting fermentative to respiratory metabolism, probably through modulating the NAD(+)/NADH ratio.
Q12746
Q67ES9
TR104_RAT
Taste receptor type 2 member 21
Rattus
MLSMLESILLSVATSEAMLGILGNIFIVLVNCTNWVRNKKLSKINFILTGLAISRVFTIWIITLDAYTKVFFLTTLMPSNLHECISYIWVIINHLSVWFATSLSIFYFLKIANFSHYIFLWLKRRADKVFVFLIGYLIITWLASFPLAVTVIKNIKVHHNNTSWLIQLEKRELLINYVFANMGPISLFMVAVFTCFLLTISLWRHRRRMQSTGSKFRDLNTEVHVKAMKVLISFIILFILYFMGVLIETLCLFLTENILLFIFGFTLSSTYPCCHSFILILTSRELKQASMRALQRLKCCET
Putative taste receptor which may play a role in the perception of bitterness.
Q67ES9
D2TDP0
SSUD_ERWP6
FMNH2-dependent aliphatic sulfonate monooxygenase
Erwinia
MRLSVFWFLPTHGDGKYLGTNEGARPVDHAYLQQIAQAADRLGFGGVLIPTGRSCEDAWLVAASLIPVTQRLRFLVALRPGVISPTQAARQAATLDRLSNGRALFNLVTGGDAEELAGDGVFLDHGERYAESAEFTRVWRRVLEGETVDYKGKHVHVRGARLMFKPVQQPRPPLWFGGSSEVAQDLAAEQVDVYLTWGEPPAQVKEKIARVQAKAAARGRKVRFGIRLHVIVRETNDEAWQAADRLISHLDDQTIAKAQAALARTDSVGQQRMAALHGGKRDRLEISPNLWAGVGLVRGGAGTALVGDGPTVAARMQEYADLGIETFILSGYPHLEEAYRVGELLFPHLELNIPEVPKPAAVQAHGEHVAHDFAPQKVPQGER
Catalyzes the desulfonation of aliphatic sulfonates.
D2TDP0
Q62052
P_MOUSE
Pink-eyed dilution protein
Mus
MRLENKDIRLASAVLEVELHQTSALSVPTCPDPGRLLTVKPATSNYKLGQADPCIPYAGEAAGKSVCVPEHTEFGSFLVKGSSSLKDLSFKEDTPLLWNSSQKKRSQLMPVHHPEFIATEGSWENGLTAWEQKCMLGKEVADLSALASSEKRDLAGSVHLRAQVSKLGCCVRWIKITGLFVFVVLCSILFSLYPDQGKFWQLLAVSPLENYSVNLSGHADSMILQLDLAGALMAGGPSGSGKEEHVVVVVTQTDAAGNRRRRPQQLTYNWTVLLNPRSEHVVVSRTFEIVSREAVSISIQASLQQTRLVPLLLAHQFLGASVEAQVASAVAILAGVYTLIIFEIVHRTLAAMLGALAALAALAVVGDRPSLTHVVEWIDFETLALLFGMMILVAVFSETGFFDYCAVKAYQLSRGRVWAMIFMLCLMAAILSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFLGICLVLLVSFPLLRLLYWNKKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRGLLLEKVLALEHLLAQRLHTFHRQISQEDKNWETNIQELQRKHRISDRSLLVKCLTVLGFVISMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALTHLHLVEYVGEQTALLIKMVPEDQRFAAAIVLIVWVSALASSLIDNIPFTATMIPVLLNLSQDPEISLPALPLMYALALGACLGGNGTLIGASTNVVCAGIAEKHGYGFSFMEFFRLGFPVMLMSCTIGMCYLLIAHIVVGWN
Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. It can modulate intracellular glutathione metabolism.
Q62052
F1CJ80
KA23J_HOTJU
U10-hottentoxin-Hj3a
Hottentotta
MQKLLIILILFCILKFNVDVEGRTATMCDLPECQERCKRQNKKGKCVIEPEMNIVYHLCKCY
May block potassium channels.
F1CJ80
P0DO11
FLZ17_ARATH
FCS-Like Zinc finger 17
Arabidopsis
MTKISVGLQLVTRDSREKLNNIVIKSSLRLNRSNPNISELCFLKTCHLCNKQLHQDKDVYMYRGDLGFCSRECRESQMLIDDRKELEASTKMMLASYRRCNNGAGKSESRNLFDDLRRRRQLFIVP
May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway.
P0DO11
Q6L367
IF1C_SACHY
Translation initiation factor IF-1, chloroplastic
unclassified Saccharum
MTEKKNRREKKNPREAKVTFEGLVTEALPNGMFRVRLENDTIILGYISGKIRSSSIRILMGDRVKIEVSRYDSSKGRIIYRLPHKDSKRTEDSKDTEDLKDTKDSKD
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Q6L367
P09824
NIFB_RHIME
Radical SAM assemblase NifB
Sinorhizobium
MSTPMILRESRTSTTFSDQLLENAKSVGCSPPSTAPGDIDPGTWDKIKNHPCFSEEAHHYFARMHVAVAPACNIQCNYCNRKYDCANESRPGVASEKLTPDQAVRKVIAVANEVPQLSVLGIAGPGDACYDWKKTRATFERVAREIPDIRLCISTNGLSLPDHVDELAEMNVDHVTITINMVDPRVGVKIYPWIYYGQRRHTGIDAARILHERQMLGLEMLAERGILTKVNSVMIPGVNDEHLIEVNKVVKGRGALLHNVMPLISNRIHGTYYGLTGQRGPEAFELQALQDRLEGTKLMRHCRHCRADAIGLLGDDRGHEFTLAEIPDEITYDASKRQAYRQLVARERGDHLVAKNEANRTVMSVEYGGSLLIAVATKGGGRINEHFGHAKEFHVYTVSQRGIKLAGRRRVEQYCLGGWGEVATLDHIVVALEGIDILLCVKIGDYPRKQLTQAGLRATEAYGHDYIESALGALYAAEFGIEPPVKTATA
Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
P09824
P54110
RS14Z_METJA
30S ribosomal protein S14 type Z
Methanocaldococcus
MAKKPWKKKYGYGIRPCQRCGHVGPGLIRKYGLNLCRQCFREIAHKLGFKKLD
Binds 16S rRNA, required for the assembly of 30S particles.
P54110
Q73M68
RPIA_TREDE
Phosphoriboisomerase A
Treponema
MDTSQLKERVAYHAIDTLFSEGKIFDGMKIGLGTGSTAMPAVHRLAQLLSSGKLKKIYAVPTSFQTSIECEKLGIPIYSLSSQQIGGSLDLAIDGADEIDPDKNLIKGGGAALLKEKIIAYNSKEFVVIADERKKVKSMGKGFALPIEIIPEARLSITKALEAQGIEVFLREGVKKMGPVVTDNGNFIIDVKWPKAADVDPKALEESLNKITGVVENGFFTKNTPRVFIVHQDGNIEDL
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Q73M68
P05934
CALM_STRPU
Calmodulin
Strongylocentrotus
LTMMARKMKETDSEEEIREAFRVFDKDGNGFISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVAMMTSK
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.
P05934
P0C0I7
SPEH_STRP1
SPE H
Streptococcus
MRYNCRYSHIDKKIYSMIICLSFLLYSNVVQANSYNTTNRHNLESLYKHDSNLIEADSIKNSPDIVTSHMLKYSVKDKNLSVFFEKDWISQEFKDKEVDIYALSAQEVCECPGKRYEAFGGITLTNSEKKEIKVPVNVWDKSKQQPPMFITVNKPKVTAQEVDIKVRKLLIKKYDIYNNREQKYSKGTVTLDLNSGKDIVFDLYYFGNGDFNSMLKIYSNNERIDSTQFHVDVSIS
Mitogenic for human peripheral blood lymphocytes.
P0C0I7
Q66JA6
CAB45_XENLA
Stromal cell-derived factor 4
Xenopus
MVSKQAFLFSLGSLYLSLLFIFLLMDVYARPANNSALKVETKEKATDNKDENEILPPDHLNGVKMEMDGHLNKEFHQEVFLGKELEEFDEDSEPRRNRRKLAAIFAKVDRNEDKQISASEMQRWIMEKTEEHFQEAVNENKLHFRAVDPDGDGHVSWDEYKIKFLASKGFNEKEVAEKLKNNEDLKIDEETQEVLDNLKDRWFQADNPPPDQLLNEEEFLSFLHPEHSRGMLKFMVKEIIRDLDQDGDKKLTLSEFISLPVGTVENQQAQDIDDDWVRDRKKEYEEVIDANHDGIVTMEELEEYMDPMNEYNALNEAKQMIAVADENQDHLLSLEEILKYSEYFTGSKLMDYARNVHEEF
May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.
Q66JA6
B2V7F0
ILVC_SULSY
Ketol-acid reductoisomerase type I
unclassified Sulfurihydrogenibium
MANIYYDEDASLDYLKDKTVAIIGYGSQGHAHALNLRDSGIKVIIGLLAGSRSIEKAKAEGFEVYSPDEAAKKADVIMILTPDTVQPALYQSAILPNLDEGNALAFAHGFNIHFGQIVPPSYVDVFLVAPKGPGHLVRWMYEEGKGVPGLFAVYQDFTGKAREIAMAYAKGIGATRAGLIETTFKEETETDLFGEQAVLCGGATALIKAGFETLIEAGYQPEVAYFECLHELKLIVDLIYQYGISGMRYSISDTARYGDVTRGKRVYEAVKPLYKKILEEIQEGEFAKEWILENVANRPHFNALVKKDEEHPVEKVGKELRKMMPWLGGRGL
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
B2V7F0
Q30Y35
GATB_OLEA2
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Oleidesulfovibrio
MAEYEVVIGLEVHAQLRTSSKLFCACSTEFGSEPNTNVCEICSGMPGVLPVVNRKAVEYAVMMGMAVDCTINNDSVFARKNYFYPDLPYGYQISQFERPLCEHGHLDIPVNGGTKRIGITRIHMENDAGKNIHSAADNASYVDLNRAGTPLIEIVSEPDMRSAEEAVAYLKELRSILLYLGICDGNMEEGSFRCDANVSLRPAGQKEFGTRTELKNVNSFRNVQRAIEVEIARQQDLLEDGEKVVQETRLYDAARNVTASMRGKEEAHDYRYFPDPDLIPLHLEDGWLQEWRKALPELPALRRTRFMEQYGLSVQDAELLTAERELADFYEAAVRHGGVPKKVANLMMGEFMRELNERRISVNEAAMTPEAVAELVRLQEEGVVSSKIVHDIFSDLFTSGSMPEAYVKAKGLVQISDSGAIETAVDEVLAENPAEVEAYRGGKTKLMSFFMGQVMRKTRGKANPAVVTGLLTEKLG
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Q30Y35
Q9SVM8
RBG2_ARATH
Small RNA binding protein 3
Arabidopsis
MAFCNKLGGLLRQNISSNGNVPVTSMLGSLRLMSTKLFIGGLSWGTDDASLRDAFAHFGDVVDAKVIVDRETGRSRGFGFVNFNDEGAATAAISEMDGKELNGRHIRVNPANDRPSAPRAYGGGGGYSGGGGGYGGGGGGYGGGGGGYGGGGDGGGGF
Promotes the cis-splicing and editing of several mitochondrial RNAs (including NAD5 transcripts) . Plays a role in RNA transcription or processing during stress. Binds RNAs and DNAs sequence with a preference to single-stranded nucleic acids. Displays strong affinity to poly(U) sequence. Exerts cold and freezing tolerance, probably by exhibiting an RNA chaperone activity during the cold and freezing adaptation process. Mediates cell-to-cell trafficking of RNA interference (RNAi) signals (small RNAs (sRNA), e.g. small interfering RNA (siRNA) and microRNA (miRNA)) which regulate growth and development, as well as responses to environmental inputs, including pathogen attack; can compromise zucchini yellow mosaic virus (ZYMV) and tobacco rattle virus (TRV) infections at the early stage .
Q9SVM8
B7L8B3
ILVD_ECO55
Dihydroxy-acid dehydratase
Escherichia
MPKYRSATTTHGRNMAGARALWRATGMTDADFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEAAGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDSQSDQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVELTKRYYEQNDESALPRNIASKAAFENAMTLDIAMGGSTNTVLHLLAAAQEAEIDFTMSDIDKLSRKVPQLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNRDVKNVLGLTLPQTLEQYDVMLTQDDAVKNMFRAGPAGIRTTQAFSQDCRWDSLDDDRANGCIRSLEHAYSKDGGLAVLYGNFAENGCIVKTAGVDDSILKFTGPAKVYESQDDAVEAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTSFLKSMGLGKACALITDGRFSGGTSGLSIGHVSPEAASGGSIGLIEDGDLIAIDIPNRGIQLQVSDAELAARREAQDARGDKAWTPKNRERQVSFALRAYASLATSADKGAVRDKSKLGG
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
B7L8B3
P08006
OPPC_SALTY
Oligopeptide transport system permease protein OppC
Salmonella
MMLSKKNSETLENFSEKLEVEGRSLWQDARRRFMHNRAAVASLIVLFLIALFVTVAPMLSQFTYFDTDWGMMSSAPDMASGHYFGTDSSGRDLLVRVAIGGRISLMVGIAAALVAVIVGTLYGSLSGYLGGKIDSVMMRLLEILNSFPFMFFVILLVTFFGQNILLIFVAIGMVSWLDMARIVRGQTLSLKRKEFIEAAQVGGVSTASIVIRHIVPNVLGVVVVYASLLVPSMILFESFLSFLGLGTQEPLSSWGALLSDGANSMEVSPWLLLFPAGFLVVTLFCFNFIGDGLRDALDPKDR
Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane.
P08006
B7UM03
RLMF_ECO27
rRNA adenine N-6-methyltransferase
Escherichia
MSAQKPGLHPRNRHHSRYDLATLCQVNPELRQFLTLTPAGEQSVDFANPLAVKALNKALLAHFYAVANWDIPDGFLCPPVPGRADYIHHLADLLAEASGTIQANASILDIGVGANCIYPLIGVHEYGWRFTGSETSSQALSSAQAIISANPGLNRAIRLRRQKESGAIFNGIIHKNEQYDATLCNPPFHDSATAARAGSERKRRNLGLNKDDALNFGGQQQELWCEGGEVAFIKKMIEESKGFAKQVMWFTSLVSRGENLPPLYRALTDVGAVKVVKKEMAQGQKQSRFIAWTFMNDEQRRRFVNRQR
Specifically methylates the adenine in position 1618 of 23S rRNA.
B7UM03
C4Y459
GATB_CLAL4
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial
Clavispora
MEEKSQVQLDSHIFNTTSSSSQYYPLNVMISRSIKGWRPEPGYPFKCGIEIHTQLKTKHKLFSLSKNSPGAAPNTCASYFDFGLPGTIPKLNPEALLLALRAAVALKSDISSISSFDRKHYFYMDQPLGYQITQHYQPLAKNGHLSLVPRLDDVEEAKTIHVEQIQLEQDTAKLNYNAYDGTVDIDHNRANVPLIEMVTKPDFSHLSELRAFVKKYISLMTHLGVCSGDMENGALRCDVNVSVAGGNRVEIKNLGSTSEIIAAAKYEYARQVQLLKHGKTPVEQETRSWDGTKTIRTRSKEDAIDYRYFPDVELPRIRLHPSIGKDLSQTLPELPEQLIQQLCEEPFLLEVKHARFLVENPDLYNYYKNLHHIIVDKHKLSYKVVNNWIIHEFIGAFNKLDIPVDVSVIDTEKLASLIIMVSEKKISITSAKLLLTQILQSPEDRELSIPDLIDAYDLGAVNDIHGDDLKEAIKEVCSEVIDSHPDVVTKIRNGKTKSINFLIGRAMKETQGKVDSKEFEKMFKKLIG
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
C4Y459
P16591
FER_HUMAN
p94-Fer
Homo
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
P16591
Q9CJJ0
ADDB_LACLA
ATP-dependent helicase/nuclease RexB
Lactococcus
MEILYTEITQDLTEGLLEISLEELEKNRKVYYIVPSSMSFEKEKEILERLAKGSDSAVFDLLVTRFKQLPYYFDKREKATTKTELGTAGLSMLFRRVLRSFSKEEIPLYFSLQDSAGFLEMLIQLRTELLTANLSVENLPDSPKNQELKKILSRFEEKLANDYANYSEFGDFTSRLADGEFDFQLKDVTIVIDGYTRFSAEEELFIESIQDRVARFVIGTYSDENSLTAGSETIYISTSQMIGRFRSKFPVELRKMAFSSVNEVYNKLTKLLDLDSRFAISDQNIEINSADAKYFRIWEAENQKVEIEGVAKEIRQKISQGAFFKDFTVLVGDPAAYEITLKEIFELYEIPFFYAQEESMSQHPLVIFFESLLSIKKNNYGTDDVVNLLKSKVYTDVNLDEEVIDYFEYYVQKYKISGRKKFTEAFNESEFSKIELVNQLRENLLGNDSPLQVFLGTNRQKTGKKWVSDLQVLLENGNVMANMNTYFSEAESENKHQMADKHEQVWQMLISILNEFLAVFSDEKLKSVEFLDILLAGLKNAKYRQIPANVDVVNIKDYELVEPKTNKYIYAIGLSQTNFPRIKKNSTLLSDEERLEINQTTDENQFIEQLNVVNYQKNQFTVLSLVNSAKETLVLSMPQIMANEQGEFSPVFQLFLNHSDEKILQKIQEVNLFESLEHIGNSRSVISMIGKIERELVETEEKNDDKRVFWSSIFRILVKSNPDFQKILLDLAKDIDTVNLSQETLDQIYGDKLYASVSSFERFYNCEYQYFLETTLGLETFENIDINSKIVGNFFHEVFEKVMQEEALSAENFDEKLTKVLHDVDSNYSRYFTHDATARFTWTNLEEIVRQTATVLKETVSTDELKTLLTESSFGLPKSELGNFSVDDIYLRGRIDRLDQLSSDYLGAIDYKSSAHSFKLQDAYDGLSLQFMTYLDVIKEAFPNQKIWGALYLQFKNQPINLSEINHLSEIAGLLKESMRYDGLVLEEAADQIKAIENITVKKSNIYNQEEFEQLLKLNENHYQHAGQRLKSGQIAINPIMKRSEGIDQTGNVRGCRYCPLKSICRFEANVHMNDHSREIGQKSQAEILAELKGEGRNE
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity.
Q9CJJ0
Q2IJ55
RL19_ANADE
50S ribosomal protein L19
Anaeromyxobacter
MLRKAIADIEAKYLRTDLPEMRAGDSVRVHTKIKEGDKERIQVFEGVVIAYRKGAPGSSMFTVRKVSYGVGVERMFPVHSPRIDKIEVVGHGGVRRSRLYFLRNLQGKAARLHQEEGPGAADAAHAAPTPA
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Q2IJ55
Q2P8Z6
PYRF_XANOM
OMP decarboxylase
Xanthomonas
MSRAPLPLAAHERLIFALDVPSHDEAIAWVDRLGDSVAFYKIGMELLASGEYFHVLDALAKRDKRVFVDLKFFDIPATVAGTIRRLAQWPVSYCTVHGWHAGMLQAAADANHGAMRLLAVTVLTSMGRPDLAAMGIDREPVDVVVERALAAEAAGIDGVIASGQEAGPIRRATGPAFSIVCPGIRPGGPVADDQQRIVGVAQAFTDGADAIVVGRPIRLAADPAAAAAAIQAEILAAVGQDRS
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Q2P8Z6
A9WPN2
GATA_RENSM
Glutamyl-tRNA(Gln) amidotransferase subunit A
Renibacterium
MTELIKLSAAALAAKLASGEVTSVQVTQAYLDRIALVDGELNAFLHLNAEEALRVAAEVDADRAAGKELHELAGVPIAIKDLIVTKGQPTTAGSKILEGWISPYDATVIEKIRAAKMPILGKTNLDEFAMGSSTEHSAFGPTRNPWDLTRIPGGSGGGSAAAVAAFEAPLALGTDTGGSIRQPGAVTGTVGVKPTYGGVSRYGAIAMASSLDQIGPVSRTVLDAALLQEVIGGHDPKDSTSLVDPINGQTGCTGLADAARLGANGDLTGVRIGVVKELGGEGYQEGVEVRFRESLELLRGAGAEIVEVSCPSFGYALGAYYLIMPSEASSNLAKFDGVRFGLRKLPEDGPMTIERVMSATRAAGFGNEVKRRIILGAYALSAGYYDAYYGSAQKFRTLIQRDFEAAFAQADVLISPTAPTTAFKFGEKMADPLAMYLNDVATIPANLAGVPGMSLPNGLADEDGLPSGIQLLAPAREDALMYRVGAALEALHEAQWGGPILDRAPELGAASNATAVEGTK
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
A9WPN2
Q8UGE7
RS6_AGRFC
30S ribosomal protein S6
Agrobacterium tumefaciens complex
MALYEHIFLARQDISAQQVDALVEQYKGVIESFGGKVGRVENWGLKSLTYRIKKNRKAHYALMDIDAPAAAVHEVERQMRINEDVLRYMTIAVEAHEEGPSAMMQKRDRDDRPRRDGDRPDRGPREDRGPRPPREGGFGDREDRPRRPREDRA
Binds together with S18 to 16S ribosomal RNA.
Q8UGE7
A6VMI0
DAPE_ACTSZ
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Actinobacillus
MKHNIIELAQNLIRRPSVSPDDQGCQQMIAQRLEKLGFTIEWMPFNNTLNLWAKHGCGAPVIAFAGHTDVVPTGDKSQWVYPPFEAEIVDDMLYGRGAADMKGSLAAMVVAAEEYVKANPNHAGTIAFLITSDEEAAAKDGTVRVVETLMARGEKIDFCMVGEPSSSKTLGDIVKNGRRGSVTGNLYIEGVLGHVAYPHLAENPVHKALPFLQELTAYQWDNGNEFFPPTSLQIANIQAGTGSNNVIPGELYVQFNLRYCTEVTDEFIKNTVAEMLKKHGLAYRIEWNLSGKPFLTEPGKLVDAVVDSLESVAGVKPKLDTGGGTSDGRFIALMGAEVVELGPLNATIHKVDERVSVTDLVTLGAVYNQMLVNLLD
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
A6VMI0
Q8S8N6
PLA2A_ARATH
Secretory phospholipase A2-alpha
Arabidopsis
MAAPIILFSFLLFFSVSVSALNVGVQLIHPSISLTKECSRKCESEFCSVPPFLRYGKYCGLLYSGCPGERPCDGLDSCCMKHDACVQSKNNDYLSQECSQKFINCMNNFSQKKQPTFKGNKCDADEVIDVISIVMEAALIAGKVLKKP
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Releases lysophospholipids (LPLs) and free fatty acids (FFAs) from membrane phospholipids in response to hormones and other external stimuli. Modulates the trafficking of PIN proteins to the plasma membrane . Negatively regulates MYB30 transcriptional activity and hypersensitive response control .
Q8S8N6
Q8Y7I9
LUXS_LISMO
Autoinducer-2 production protein LuxS
Listeria
MAEKMNVESFNLDHTKVKAPFVRLAGTKVGVHGDEIYKYDVRFKQPNKEHMEMPALHSLEHLMAELARNHTDKLVDISPMGCQTGFYVSFINHSDYDDALEIIATTLTDVLVATEVPACNEVQCGWAASHSLEGAKALAEEFLAKRSEWKNVFGE
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
Q8Y7I9
Q03QS9
DPO3_LEVBA
DNA polymerase III PolC-type
Levilactobacillus
MDEDRHALFEKLLQQLDLTSEADQPYFQTATVDRLTVHEQSRRWQFLLKLPSMLPFTAFVDFHNHLQVAFREIATVEATIEVDQPELTNRLLGDYWEWIVKNSGLTSNLIQELCQSQVPELDENNRVLLYAQNEVVKDFLSNQALGPIESAYRRAGFPKFNIHVMIDESKSQAKIDEFKARQEKTDAQLAQQAAAAIEKANQKRQSQGDTPAAEGPTQIGKAIKGDQPVTKMIDITQEERSVVVEGYVFEKEVRKLRSGRQLLTLKITDYTSSFAVKKFSRGAEDEAQFAGVEEGSWVKVRGNVQEDTYMHDLALNAYDINQVKHASRQDTAPEGEKRVELHLHTSMSQMDATNSIGDYVKQAKKWGMPALAITDHADVQGFPAAFNSAAKAGIKMLYGVEANLVDDGVPIGYNSAHVPLDGATYVVFDVETTGLSAIYDKVIELSAVKMEHQNVVDQFEEFIDPGFPLSEQTTNLTSITDDMVAGSKSEEEVFKLFREFCGDAIIVGHNVTFDVGFMNTGYQRHGMAEISNPIIDTLTLARFLYPTLKSYRLNTLAKRFHVSLEHHHRAVYDAESTGHLNYLFLKDAEDRYDIQYHDQLNDHMTDNDAYKHARPNHAILLAKTQAGLKNMFKLVSASNVDYYYRVPRVPRSVLEEYREGIIVGSACSSGEVFTAMMQKGQVEAAAKAKFYDYLEVQPSAAYQPLIDSGLIADRENMEEIVRNMVKLGHDLNKPVVATGDVHFLNPDDYIYRKILIHSQGGANPLNRQELPDVHFMTTDEMLTDFAYLGEETAKEIVVTNTQKIADDIDEVHPLKDKLYTPRMEGAEDEIRQRTMDTAHAMYGDPLPELVQHRVDRELKSIIGNGFSVIYLIAQRLVAKSNKDGYLVGSRGSVGSSLVATLTGITEVNPLPPHYRCPKCQYSHFYTKGEYSSGYDLPEKDCPECGTLMIGDGHNIPFETFLGFKGNKVPDIDLNFSGDYQPIAHNYTKVLFGEKNVYRAGTIGTVADKTAYGYVKAYERDTEQTFRGAEIDRLAKGATGVKRTTGQHPAGIIVVPDYMDIFDFTPIQYPADDQSAAWQTTHFDFHSIHDNILKIDILGHDDPTMIRTLQDLSGVDPTTIPMDDPGVMGLFSGTDSLGVTPEQIQSKTGTLGVPEFGTRFVRGMLEETHPQNYSQLLQISGLSHGTDVWLGNAEELIKNGTATIANVIGCRDNIMTDLINFGLDSETSFQVMEHVRKGRGIPDEWQEKMKATDCPDWYIDSCLKIKYMFPRAHAAAYVLMALRVAYFKVYFPIIYYAAYFSVRADDFDVVAMSQGKTAVKAAMKAINDQGMDASAKDKNLLTVLELANEMLERGFKFKMIDLEKSDAADWIIDGDTLIAPFKAAPGLGLNVAKQIVAARNDRPFISKEDLAKRGKVSKTLIDFMTENGVLAGLPDENQLSLFDDLM
Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Q03QS9
B1VZW1
DNLJ2_STRGG
Polydeoxyribonucleotide synthase [NAD(+)] 2
null
MAGEDRVEQESSVPADVREKHALLAEQIEEHRFRYYVKDQPVVSDADFDRQLRSLEALEEEHPSLRTPDSPTQKVAGPYRTEFTSVEHRERMLSLDNAFDDEELAAWADRVAKDVGTPDHHFLCELKVDGLAVNLTYEHGRLTRAATRGDGRTGEDITPNVRTIAEIPHRLKGEDIPALVEIRGEVFFPMEDFEELNARLVAADDKPFANPRNAAAGSLRQKDPKVTATRPLHMVVHGIGAHEGLSIDRLSAAYDLLHTWGLPTARHNKVVDSLAGVREFIAHYGENRHSVEHEIDGVVVKLDEIPLQGRLGSTSRAPRWAIAWKYAPEEVNTKLVNIRVGVGRTGRVTPYAQVEPVEVAGSEVEFATLHNQNVVKAKGVLIGDTVVIRKAGEVIPEILGPVVDLRDGTEKAFEMPTHCPECGTELRPMKEADIDLRCPNARTCPAQLRERVFYLAGRKSLDIDHFGYVAAAALTRPLEPAEPVLKDESDLFSLTVEQLLPIRAYVLDQDSGLPKRDPKTGEEKIATVFANQQGEPKKNAVAMLEGIAAAKDAPLARVLTGLSIRHVGPVAAQELARQFRSIERIDEATEEELAAADGVGPTIAASVKQWFAEDWHREIVRKWREAGVRMADEGSDEDEGPRPLEGLTVVVTGTLAGHTRDGAKEALQALGAKVAGSVSKKTAFVVVGDNPGSKYDKAMQLKVPVLDEDGFAILLEQGPERAKEAALPVPEAAPAADPENSGE
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
B1VZW1
Q5FNB7
MSCL_GLUOX
Large-conductance mechanosensitive channel
Gluconobacter
MSETKHTLHTPGWVSDFQKFIMRGNVLDLAVGVVIGAAFSAIVGSAVKDILTPFIGLITGGVDFSNLFITLKGPVKDTLAEAQKAGAVTVNIGVFLNAVIQFLIIAFFIFWLTRILSKLSRKQEAAPAAPPAPTKEEVLLTEIRDLLAQKNS
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Q5FNB7
Q80SY6
ADAL_MOUSE
Adenosine deaminase-like protein
Mus
MEAGQQWPGKTDFYLQLPKVELHAHLNGSISSSTMKKLIAKKPHLNVHGHMTMIDKGKKRTLQECFQMFQVIHQLTTSAEDILMVTKDVIKEFADDGVKYLELRSTPREENATGMTRKTYVESVLEGIKQCKQENLDIDVRYLMAIDRRGGPTIARETVELAKEFFLSTENTVLGLDLSGDPTIGQANDFLEPLLEAKKAGLKLALHLAEIPNREKENQMLLSLLPDRIGHGTFLSASEAGALDQVDFVRQHQIPLELCLTSNIKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFATYLSQEYQLAAETFNLTPFQVWDLSYESINYIFACDNTRSELRKRWTHLKQKVLNCNEVNYF
Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A).
Q80SY6
B0BVB7
ATPG_RICRO
F-ATPase gamma subunit
spotted fever group
MSNLKQLRTRIKSVKSTQKITKAMQLVSASKMAKIKSQIANSNFYIEAVSKMMSAILSIDMYELSIEEQKFFNTVPNKANLLIVMTSQRGLCGTFNYSIIQQVKNDIKELENKGEQIKLIIIGKKGYEALKRQYVNYIDSYFELPKIHDENLMLQVKQKIMSAVENLEVSNCVIYFNKFKNAMTQIMTRQQILPVAKYQDDSMIDNPIVNLVGFGYKERGAKPINNRSATSDIVGESKSIDYNYEYEGENLISNLINLYVNSQINYALLQSRASEEGARMTAMENATNNANDLISKLVLKLNRSRQAIITTELIEIIAGSEAV
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
B0BVB7
A0KND9
PNP_AERHH
Polynucleotide phosphorylase
Aeromonas
MNPIVKSFQYGQHTVTLETGVMARQATAAVMVSMDDTCVFVTVVGKKEADHGRDFFPLTVNYQERTYAAGRIPGGFFRREGRPSEGETLISRLIDRPIRPLFPEGFLNEVQVVATVMSVNPAVSPDIVAMIGASAALAISGIPFGGPIGAARVGYMNGQYVLNPTTTELPQSDLDLVVAGTANAVLMVESEAAILSEEVMLGAVVFGHEQMQAVINAINEFAADVGTKPWNWTAPAVNEALKAKVAELATAELGEAYRITEKAVRYETIGAIKARVVEQVIASGVEEDAKKIGEEFHSLESRIVRGRVVRGEPRIDGRDPEMIRALSVATGVLPRAHGSALFTRGETQAMVVATLGTERDAQNIDELTGNRADRFMLHYNFPPYCVGETGMMGSPKRREIGHGRLAKRGVAAVMPSADEFPYVVRVVSEITESNGSSSMASVCGSSLALMDAGVPIKASVAGIAMGLVKEEEGFVVLSDILGDEDHLGDMDFKVAGTTEGVTALQMDIKIEGITKEIMEIALKQARGARLHILKVMDEAIQAPRAEISDFAPRIHTIKINPEKIKDVIGKGGSVIRALTEETGTNIELDDDGTVRIAAVDGDAAKEAIRRIEAITAEIEVNRIYEGKVVRLADFGAFVNILPGKDGLVHISQITDARVQNVADYLKIGDVVKVKVLEVDRQGRVRLSIKEANAPTEAAAEPAVAAVEEPAAE
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
A0KND9
P59851
KAX2Z_CENLM
Potassium channel toxin alpha-KTx 02
Centruroides
TVIDVKCTSPKQCLPPCAKQ
Potent selective inhibitor of Kv1/KCNA voltage-gated potassium channels.
P59851
Q143I2
DCD_PARXL
Deoxycytidine triphosphate deaminase
Paraburkholderia
MTIKSDKWIRRMAESHKMIEPFAPDQVRVSEDGRKIVSYGTSSYGYDIRCADEFKIFTNINSTIVDPKNFDEKSFVDFKGDVCIIPPNSFALARTVEYFRIPRSVLTVCLGKSTYARCGIIVNVTPFEPEWEGHVTLEFSNTTPLPAKIYANEGVAQVLFFESDEICETSYADRGGKYQGQHGVTLPRT
Catalyzes the deamination of dCTP to dUTP.
Q143I2
Q9ZB21
UVRB_MYCPL
Excinuclease ABC subunit B
Mycoplasmopsis
MEEKFVLHSPFAPSGDQPEAIKALVDGIDEKKEHQVLLGVTGSGKTFTIANVIAQLNRPSLIISHNKTLASQLYSELKALFPDNRVEYFVSYFDFYKPEAYIPKSDLYIEKTSKNNKELEAMRMSAINALSIRKDTIVVASVAAIYGESNPKHYRQNFFPIEVGMQIDRKSLLLKLSQIGYERNRMELNKGQFDVKGDSIEICPGYVSDTNIRIDMFGNEIEAITLIDPLSKNVEGSRKNMTLFPATTYTVHENTIQNTVDLIKQELSERIEYFKSHDKLLEAQRIKDRTLNDLDSLLEFGYTSGIENYSRYLDGRAPGQRPYTLFDYLPDDSVIFIDESHLMIPQLHGMHNGDRARKLSLVEYGFRLPSALDNRPLRFEEFAEFKFPKIYISATPGDYELDLTHGEIVTQYIRPTGLLDPIIEIHSRDNQIEDIYDHLKEQIAKKERTLILTTTKKNAEELSLFLQEKKIKSAYIHDRFKIFERNEILKGLRMGKFDVVVGINLLKEGIDLPEVSLICVLNADSTGLMRDTRSLIQIVGRAARNDHGKVIFYANEITSSMRECIEDNLFKRKIQSEYNEKHNIIPKTIVKPIAPPIQNGILSEDHSKYYGEKDLSQMKHNKKFIDQMVRKMTQLAKANKFEEAIEIRDYLIEIGIELDK
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
Q9ZB21
P0DKV3
APOC1_ATEGE
Truncated apolipoprotein C-I
Ateles
MRLFLSLPVLVVVLLMILEGPGPAQGAPEALDTSSGLDKLKEFGNTLEDKVREFFNRVKESDIPAKTRNWFSETLQKVKEKLRIES
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
P0DKV3
Q1BXP1
ASTD_BURCA
Succinylglutamic semialdehyde dehydrogenase
Burkholderia cepacia complex
MTELFIDGAWVAGSGPVFASRNPGTDAVAWQGESASAADVDRAVASARRAFAGWSALDFEARCEIVKRFAALLTERKEAIATAIGRETGKPLWEARTEVASMAAKVGISIQAYQERTGEKRQDMADGVAVLRHRPHGVVAVFGPYNFPGHLPNGHIVPALIAGNTVVFKPSELAPGVARATVEVWQEAGLPAGVLNLVQGEKDTGIALANHRQIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVIGEVEDIDAAVHHTIQSAFLSAGQRCTCARRIFVPQGAFGDRFLARFADVTSKITADVFDADPQPFMGAVISARAAAKLVDAQARLVEQGAKPIVAMAQRDPRLGFVNAAIVDVTGVANLPDEEHFGPLAQVVRYATFDEAIERANDTAFGLSAGLLADDAKVWEHFRRTIRAGIVNWNRPTNGASSAAPFGGTGRSGNHRPSAYYAADYCAYPMASVESTQLTLPASLSPGLHF
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
Q1BXP1
Q57M53
ARNE_SALCH
Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE
Salmonella
MIGIVLVLASLLSVGGQLCQKQATRPLTTGRRRRHLMLWLGLALICMGAAMVLWLLVLQTLPVGIAYPMLSLNFVWVTLAAWKIWHEQVPPRHWLGVALIISGIIILGSAA
Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane.
Q57M53
P29642
CYB_ASTDO
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Asthenes
FGSLLGICLMTQIITGLLMAMHYTADTTLAFTSVAHTCRNVQFGWLIRNLHANGASMFFICIYLHIGRGFYYGSYLFKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPMLTRFFALHFLLPFMIAGLTFIHLTFLHETGSNNPLGISSNCDKIPFHPYFSTKDILGFLAMLVPLTALAMFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLILFLIPFLHKSKQRTMTFRPLSQLLFWILVTNLLILTWVGS
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
P29642
P58719
PDXA_YERPE
4-(phosphohydroxy)-L-threonine dehydrogenase
Yersinia
MHNHNNRLVITPGEPAGVGPDLAITLAQQDWPVELVVCADPALLLARASQLNLPLQLREYQADQPAIAQQAGSLTILPVKTAVNVVPGKLDVGNSHYVVETLAKACDGAISGEFAALVTGPVQKSIINDAGIPFIGHTEFFADRSHCQRVVMMLATEELRVALATTHLPLLAVPGAITQASLHEVITILDNDLKTKFGITQPQIYVCGLNPHAGEGGHMGHEEIDTIIPALNTLRQQGINLIGPLPADTLFQPKYLQHADAVLAMYHDQGLPVLKYQGFGRAVNITLGLPFIRTSVDHGTALELAATGTADVGSFITALNLAIKMINNSNE
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
P58719
Q1LIV1
MTGA_CUPMC
Peptidoglycan glycosyltransferase MtgA
Cupriavidus
MRWLAYLAGCLIVGVVAMQVYFFLQIAAWQVVNPSSTTFMRAERWRLCGFNFWSCPVQRQWVRYDEISRNIKRAVIASEDADFVNHPGYELDAMLDAWERNKQRGRIVRGGSTITQQLAKNLFLSSEQNYLRKGQELAITWMLELWLDKQRIFEIYLNSVEWGEGVFGVEAAAQHYFHTSASKLSVGQAARLAAALPAPKCFDKKQYCANVHVNFRVKASIIARRMGAATLPD
Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors.
Q1LIV1
Q5HW21
ACCA_CAMJR
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Campylobacter
MASYLDFEKNIQQIDEDIINAQIKGDTEAVSILKKNLEKEISKTYKNLSDFQRLQLARHPDRPYALDYIELILNDAHEIHGDRAFRDDPAIVCFMGYLGEKKIIVIGEQKGRGTKDKIARNFGMPHPEGYRKALRVARLAEKFQIPILFLIDTPGAYPGIGAEERGQSEAIARNLYELSDLKIPTIAIVIGEGGSGGALAIGVADKLVMMKNSVFSVISPEGCAAILWNDPAKSEAATKAMKVTADDLKSQGLIDDVIDEPTNGAHRNKEAAAVAIADYVKKSLNELENIDVRELSANRMQKILKLGAYQEA
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
Q5HW21
A1AQS8
NIKR_PELPD
Putative nickel-responsive regulator
Pelobacter
MGETIRFGISIDDKLLESFDQLIEHKGYANRSEALRDLIRASLIDVKWENGEEEMVGTVTLVFNHHVRDLSDKLTEHQHAYHHQIISALHVHLDAHNCLEVLVVRGKAREIKKIADELIGVKGVKHGKLVMTATGHDLH
Transcriptional regulator.
A1AQS8
A8FEQ8
SCPA_BACP2
Segregation and condensation protein A
Bacillus
MLEYQVKIDSFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLYVHTMRELELDVASEYLVMAATLLSIKSRMLLPKQEEELFDEDLLEEEEDPREELIGKLIEYRKYKDAAQELKEREEERQNAFTKPPSDLSEFAKESEAKDTNLHVTVYDMLGAFQKVLNRKKITKPAPSRITRQEIPIEDKMNEIMNHLRKTKKRTNFMTLFQHDQKEHLVVTFLAVLELMKSHQIMLEQEGNFEDIYIIGSETIHDA
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
A8FEQ8