accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
D2KQB0
HHEX_PATMI
HEX homeodomain transcription factor
Patiria
MSTLQYPGPPPPSSMNLHNPHMNHHHGLVGPGLAPLSAPNGIQSLNTLHNGSGPPSHTPFYIDNILGSRLNMTGPARPTPTLPSPTFPAHMNSAYNSYYEQAVHPGLAAPTPISYGSGAFSSPPPYPFARGDYPHGLIDRHDPYSKVPGKPFLWNPFIQRPLHKRKGGQVRFSNDQTMELEKKFESQKYLSPPERKKLAKLLQLSERQVKTWFQNRRAKWRRVKQEVPTGKGEGDENSHEKPRDLDRDDFSREQVLSNGAACAFTHGGGSEADSLEEKEA
Transcription factor that may play a central role in activating or maintaining gene expression in the vegetal pole. Part of a gene regulatory circuit with Erg and Tgif that operates early in mesoderm development.
D2KQB0
Q6B8V8
RK22_GRATL
50S ribosomal protein L22, chloroplastic
Agarophyton tenuistipitatum
MTNKTTNIQATGKYVRLSTAKTRRVLNQIKGKKYQEAILILEFMTYKPCKIIKKILESAGNNALNLKYEKQNLIIKQAFANDGPKLKRFQPRAQGRAFRIQKPTCHITINLSIN
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Q6B8V8
A8LX76
SEPF_SALAI
Cell division protein SepF
Salinispora
MGALRKAGVWLGLVEEDDERAYDDAGYDKGGYRESRYRSSRYSEDFGDEDDEDEEAAVPRSRRGDRSRLERAAARSGDVDHNVEGEQPERVERASVRSITRSAEPSESLTYHTRDNLALAPQPVRERVPADEEQRYQITTLHPTTYREARTIGEHFRDGVPVIINLTEMDEADARRLVDFAAGLAFGLRGTIERVTNRVFLLSPANVQVTAEDKAKIAEGGFFSLS
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
A8LX76
Q3ZBV3
MGN_BOVIN
Protein mago nashi homolog
Bos
MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly.
Q3ZBV3
A7I4V4
DPCKG_METB6
Dephospho-coenzyme A kinase
Methanoregula
MFVLPDESRQLFKDPFGTLHRDIGTVLPELAGRTIYSVGDVVTHSLQQNGITPAIAVVDGQTMRSPCIKMPEIAGPCIHVKNPPGTITDELVSALTHAVDHTPVTILVDGEEDLAVIPLVIAAPLSSIVIYGQPNEGVVLRIVDDQAKTAARRLLTQFTKTESPIPHN
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
A7I4V4
Q0BCH2
KDSB1_BURCM
CMP-2-keto-3-deoxyoctulosonic acid synthase 1
Burkholderia cepacia complex
MTHPQPFIAVIPARLASTRLPNKPLADLGGKPMVVRVAERAREAGAQQVLIASDAQSVLDAARDHGFEAVLTRADHPSGTDRLAEVAATFGWSDDTVVVNVQGDEPLIDPVLVRDVASHLAAHPDCAIATAAHPIHDAADVFNPNVVKVALDARNVAMYFSRAPIPWSRDAYLPHWPDVSAMPAPAFPVHRHIGLYAYRARFLRTYPSLAQAPVEQAEQLEQLRAMWHGERIAVLITEHAPEAGIDTPADLARVQALFRPGSK
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Q0BCH2
A3PHR7
RSMH_CERS1
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Cereibacter
MAEADTERRPHIPVLLRPLLAAVAPVEGTWLDGTFGAGGYARGLLEAGADRVIGVDRDPLALKMASGWAGDYGDRLRLVAGTFSQLDSHAGAPLDGVVLDLGVSSMQLDLAERGFSFQKDGPLDMRMSQEGESAADLVNTASEESLADILYHYGEERASRRIARAIVEARAAAPITRTLALAEIVARCLPRPKPGQMHPATRSFQAIRIAVNAEFSELVEGLEAAERALRPGGRLAVVTFHSLEDRIVKRFLQLRSGGEGQGNRYAPETRAYAPRFTLPLRRAISPDEAELAENPRARSARLRVGVRTDAPAGKVDPQALGTPLIPKKGRR
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
A3PHR7
A6UW70
GGGPS_META3
Phosphoglycerol geranylgeranyltransferase
Methanococcus
MFGKVEEKLNNVLKTEGALYFILIDPDEKNCLEIAEKVKDYADAIILGGSIGITNLDETTKQIKEIIGDIPIILFPGNVDGLTPYADAVFFMSFMNSNNTYWTTTAPTLGAITVKKYNLEPISMAYLGIEPIKRTAVGFVGEVNEIPQRKPEIAGMYCLSAKYFGMRWAYLEAGSGAELPVSNEIIGISKKLSGINIIVGGGIRTPETAYQKVLSGADAIVTGTLIEDNPDAVKEMRNAIKKAGIDKL
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
A6UW70
C4L0W8
AZOR_EXISA
FMN-dependent NADH-azoreductase
unclassified Exiguobacterium
MTKVLYVSANPKPTELSYSKQVAETFVSTLKAENASIEVEAIELYDVDVQEIDGDVLSAWGKFASGEALTDVEAKKVGTMSGMLEKFMEADLYVFATPMWNFFFPARMKMFLDSVLMAGKTFRYTEQGPVGLLENKQAIHIQGTGGIYTGTDLNFADAYLRQALAFVGVSEVTTVAVEGMNQYPDKIEEIVADAKAKAEALAKEVAGAVTV
Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
C4L0W8
A7MAQ2
DIOA3_DIOJA
Tuber storage protein dioA3
Dioscorea
MSSSTLLHLLLLSSLLFSCLSCLTNVEDEFSYIEGNPNGPENWGNLKPEWETCGKGMEQSPIQLRDNRVIFDQTLGKLRRNYRAVDARLRNSGHDVLVDFKGNAGSLSINRVEYQLKRIHFHSPSEHEMNGERFDLEAQLVHESQDQKRAVVSILFRFGRADPFLSDLEDFIKQFSNSQKNEINAGVVDPNQLQIDDSAYYRYMGSFTAPPCTEGISWTVMRKVATVSPRQVLLLKQAVNENAINNARPLQPTNFRSVFYFEQLKSKLGVI
Storage protein of tuber. Involved in protection against oxidative stress (Probable). Has carbonate dehydratase, trypsin inhibitor, dehydroascorbate (DHA) reductase and monodehydroascorbate (MDA) reductase activities . Catalyzes the reactions of carbonate dehydratase and DHA reductase independently of zinc and glutathione (GSH). The coupled reaction is capable of recycling a plant antioxidant ascorbate using ubiquitous compounds H(2)O and CO(2) . Exhibits antioxidant activity. Able to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. Exhibits immunomodulatory activity. Activates Toll-like receptor 4 signaling pathways by up-regulating the gene expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-1 beta and interleukin-6, and chemokines RANTES and MCP-1, in mouse RAW 264.7 macrophages. Stimulates the phagocytosis of E.coli by the LPS-treated mouse macrophages .
A7MAQ2
P13854
MGF_CHICK
Myelomonocytic growth factor
Gallus
MCCLTPVLALALVLGAPWQALHGAPLAELSGDHDFQLFLHKNLEFTRKIRGDVAALQRAVCDTFQLCTEEELQLVQPDPHLVQAPLDQCHKRGFQAEVCFTQIRAGLHAYHDSLGAVLRLLPNHTTLVETLQLDAANLSSNIQQQMEDLGLDTVTLPAEQRSPPPTFSGPFQQQVGGFFILANFQRFLETAYRALRHLARL
Hematopoietic growth factor that stimulates the proliferation and colony formation of normal and transformed avian cells of the myeloid lineage.
P13854
P83264
PRT1_SCOSC
Scombrine alpha-1
Scomber
MPRRRRRASRPVRRRRRARRSTAVRRRRRVVRRRR
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
P83264
Q9BT25
HAUS8_HUMAN
Sarcoma antigen NY-SAR-48
Homo
MADSSGRGAGKPATGPTNSSSAKKKDKRVQGGRVIESRYLQYEKKTTQKAPAGDGSQTRGKMSEGGRKSSLLQKSKADSSGVGKGDLQSTLLEGHGTAPPDLDLSAINDKSIVKKTPQLAKTISKKPESTSFSAPRKKSPDLSEAMEMMESQTLLLTLLSVKMENNLAEFERRAEKNLLIMCKEKEKLQKKAHELKRRLLLSQRKRELADVLDAQIEMLSPFEAVATRFKEQYRTFATALDTTRHELPVRSIHLEGDGQQLLDALQHELVTTQRLLGELDVGDSEENVQVLDLLSELKDVTAKKDLELRRSFAQVLELSAEASKEAALANQEVWEETQGMAPPSRWYFNQDSACRESGGAPKNTPLSEDDNPGASSAPAQATFISPSEDFSSSSQAEVPPSLSRSGRDLS
Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Q9BT25
Q4KL97
ANKR1_XENLA
Ankyrin repeat domain-containing protein 1
Xenopus
MLLKMEEMVIEKKNEMKQTGDFVSGVSKNGEYETAVALEKQEDLKTTSKSLIELEEEKQSKEKQLKSELLKKKLEERPKLDNLEDLQTIINLKKRKRVKKVKVPVVKEPEPEETIGDVDQMTFFKAALDNKMSIIEKYLADGGDPNTCDEYKRTALHRACSEGHTAIVEKLIEAGANIEFKDMLESTALHWTCRGGSVETLKLLLNKGAAINARDKLLSTPLHVAVRTGYYECGEHLIACEADLNAKDREGDTPMHDGVRLNRYKMIRLLILYGVNLNIKNCAGKTPMELVMQWQNGAKEIFNGLQNKSYKNSHISKF
May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes.
Q4KL97
A1BJ37
EFG_CHLPD
Elongation factor G
Chlorobium
MARLVALDKVRNIGIMAHIDAGKTTTTERILYYTGRLHRMGEVHEGGATMDWMEQEKERGITITSAATTCFWSPNYGNYSGLRHRINIIDTPGHVDFTVEVERSLRVLDGAVALFCAVGGVEPQSETVWRQANKYGVPRIAYVNKMDRTGANFFDTVKAIRERLSANPVPIQIPIGEGEIFAGFVDLIRMKGVIYDKDDGSTYNEVEIPHDLQNEARTWRINMLEAVSEVDETLLEKYLNGEDITEEEIRVVLRKATLNVSIIPVLCGSSFKNKGVQFMLDAVVEYLASPVDVGAVEGHHPRTEETVVREPRDEEPFAGLAFKIATDPFVGKLTFFRVYSGVLHAGSYVLNTVTGKKERIGRVLQMHSNKREDIECVYAGDIAAAVGLKDVRTGDTICDENNPVVLEKMIFPEPVIQIAIEPKTKADSDRLGMSLAKLAEEDPTFKVKTDDETGQTLIAGMGELHLEILVDRLKREFKVEATVGQPQVAYRETIRKAVEFEGKFVRQSGGKGQFGLVNLKVEPLEEGKGYEFVDAVKGGVIPREYIPAVNAGVQQAMKDGVVAGYAMQDIKVTLFDGKYHEVDSSEMAFKIAGSIGFKGAAKKADPVLLEPIMKVEVVTPDEYLGDVMGDLSSRRGHIEGMGQRAGAQFVNAKVPLSAMFGYSTDLRSMTQGRANYSMEFECYREVPRSIAESLQEKRVSKETV
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
A1BJ37
A6NMB1
SIG16_HUMAN
Siglec-P16
Homo
MLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVAMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLRNGTSLRVLEGQSLRLVCVTHSSPPARLSWTWGEQTVGPSQPSDPGVLQLPRVQMEHEGEFTCHARHPLGSQRVSLSFSVHCKSGPMTGVVLVAVGEVAMKILLLCLCLILLRVRSCRRKAARAALGMEAADAVTD
Putative adhesion molecule that mediates sialic-acid dependent binding to cells.
A6NMB1
A1DNL0
CBHB_NEOFI
Exoglucanase B
Aspergillus subgen. Fumigati
MLASTFSYRMYKTALILAALLGSGQAQQVGTSQAEVHPSMTWQSCTAGGSCTTNNGKVVIDANWRWVHKVGDYTNCYTGNTWDKTLCPDDATCASNCALEGANYQSTYGATTSGDSLRLNFVTTSQQKNIGSRLYMMKDDTTYEMFKLLNQEFTFDVDVSNLPCGLNGALYFVAMDADGGMSKYPTNKAGAKYGTGYCDSQCPRDLKFINGQANVEGWQPSSNDANAGTGNHGSCCAEMDIWEANSISTAFTPHPCDTPGQVMCTGDACGGTYSSDRYGGTCDPDGCDFNSFRQGNKTFYGPGMTVDTKSKFTVVTQFITDDGTASGTLKEIKRFYVQNGKVIPNSESTWSGVGGNSITNDYCTAQKSLFKDQNVFAKHGGMEGMGAALAQGMVLVMSLWDDHAANMLWLDSNYPTTASSSTPGVARGTCDISSGVPADVEANHPDASVVYSNIKVGPIGSTFNSGGSNPGGGTTTTAKPTTTTTTAGSPGGTGVAQHYGQCGGNGWQGPTTCASPYTCQKLNDFYSQCL
The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes: (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds; (2) Exocellobiohydrolases that cut the disaccharide cellobiose from the non-reducing end of the cellulose polymer chain; (3) Beta-1,4-glucosidases which hydrolyze the cellobiose and other short cello-oligosaccharides to glucose.
A1DNL0
Q15QB4
LPTD_PSEA6
LPS-assembly protein LptD
Pseudoalteromonas
MKPLKLELNPRDFNHYQAAFLPYRMKIKQPLHVLCFSVCSLSAVAQETCPAPANTFVVEKRLPNGQIQVISNMTSIQQDNFAEFEGDVEITNKDSQIIANKAQIDRTTQQLIATGDVSYQNPQLSVTSQKVLLNTQNNRMEIADTQYELTTLNARGQAELLVVDQTQGLELNGVTFSTCPTGQEDWLVHADSITVKPDETRGVARNAFFYVQDIPIFYLPYYSFPVTDARETGLLFPQVGSSSSTGFAYEQPYYLNLDPQYDATITPRYMTKRGLQLKTEFRYLTENNSGQIDIEYLPNDSDSTTNEDRYFYRFTHKGALSDDWEVNVDFNGLSDDNYIVDLGSDYYNSADTHLFRTLGLHYYSDALNVSLQLRDFEILGDHDDTYRALPELKLDYVTDLPAGFKFDIHSELARFDNANGTSPKATRAHIAPTLSLPLENSWGEFLAETSIMHTVYRQEDIEGTDLSRDVSRTLGQAKLYGALVFERQAHWFGDNVTQTLEPRAQYLYTSYEDQSDIGLYDTTRLFNDFAGLFRGQEFTGLDRISDKNQVTLGVTSRIIDEDNREQFKLSLGQIFYLEDNKVTAASKEDDRSALAAELDWRIGSKWLAHSEVQVSTQTDKVERSSVGLEYRLARDKMLQINHRFVRDLSGEQISQLGLTASWPIAQDWYWVGRWYRDIDRHRTIESYTGLQYESCCWALRIVAQRQLTSRFDDDGLQSTDEFDSGIAIQFLFKGIGGDSSGRDMLRDGLFGYRQPYLLD
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
Q15QB4
C4QYF2
LIPA_KOMPG
Lipoic acid synthase
Komagataella
MLSTRVVRLPKVISGGNKQLARGLASLSDEKSLNEANPTDLAGLKRKAKRRPTKLADELKTGPSFADFVTGKAKDMLVDPLELARNDPNARLPSWLKTQIPKGKSFHHLKSDLKELKLSTVCEEAKCPNIGECWGGKKSEATATIMLMGDTCTRGCRFCSVKTNRNPAPPDPNEPENTAEAISRWGLGYVVLTTVDRDDLPDGGAHHLASTVTKIKEKAPQILVECLSGDFRGNLEMAKVLASSPLDVFAHNLETVEDLTPHIRDRRATYRQSLSVLRAAKEANPRLVTKTSLMLGFGETDDQILQTLHDLRNISCDVVTFGQYMRPTKRHMKVVEYVTPSKFEYWRDKALEMGFLYCASGPLVRSSYKAGEAFIENVIKKRRTNVGAIEEQQHDKENNNLLLSKEDEKTTQEKANF
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
C4QYF2
Q0VP64
RSMC_ALCBS
rRNA (guanine-N(2)-)-methyltransferase RsmC
Alcanivorax
MENTTQLLLRQSDALAGRNVLVVDANDPALKTLSVDATVHVHADDYTIGAQQWAPAPTVPAGTDLLVLPLSKSLDRLRFLLNWLAGEIAEPTELWLIGPTKGGIRGALKYLEAHVDGTMLEDSARHCKLYSGLLQPGEKQSLNAWGTVLEVADQEAVSYPGVFSHGRLDEGSALLLQAMEGHNLGKPGKVIDMGCGAGVISVWLARHGWQVQGVDVSASAVTASTESLARNGLQGRIMGGDLFSPIQGRVDMVVTNPPFHDRRQRTTDITRRLIAEAPTYLKPGGVLWLVANRELPYVQWLDDAFSHVQVASETTRFRVYRAVLS
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
Q0VP64
B0RZS5
RL18_FINM2
50S ribosomal protein L18
Finegoldia
MFKKIDKNANRVKRHLRIRKNLTGTSEKPRLCVFKSNTNIYAQLIDDVNHNTLVAASTLDKDFSGESKSNKEAAKLVGELIGKKAIDKGIEQCVFDRSGYLYHGKVKELAEGARSAGLKF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
B0RZS5
Q43147
C85A1_SOLLC
Protein DWARF
Solanum subgen. Lycopersicon
MAFFLIFLSSFFGLCIFCTALLRWNQVKYNQKNLPPGTMGWPLFGETTEFLKLGPSFMKNQRARYGSFFKSHILGCPTIVSMDSELNRYILVNEAKGLVPGYPQSMIDILGKCNIAAVNGSAHKYMRGALLSLISPTMIRDQLLPKIDEFMRSHLTNWDNKVIDIQEKTNKMAFLSSLKQIAGIESTSLAQEFMSEFFNLVLGTLSLPINLPNTNYHRGFQARKIIVNLLRTLIEERRASKEIQHDMLGYLMNEEATRFKLTDDEMIDLIITILYSGYETVSTTSMMAVKYLHDHPKVLEELRKEHMAIREKKKPEDPIDYNDYRSMRFTRAVILETSRLATIVNGVLRKTTQDMEINGYIIPKGWRIYVYTRELNYDPRLYPDPYSFNPWRWMDKSLEHQNSFLVFGGGTRQCPGKELGVAEISTFLHYFVTKYRWEEIGGDKLMKFPRVEAPNGLRIRVSAH
Catalyzes the C6-oxidation step in brassinosteroids biosynthesis . Converts 6-deoxocastasterone (6-deoxoCS) to castasterone (CS) . May also convert 6-deoxoteasterone (6-deoxoTE) to teasterone (TE), 3-dehydro-6-deoxoteasterone (6-deoxo3DT, 6-deoxo3DHT) to 3-dehydroteasterone (3DT, 3-DHT), and 6-deoxotyphasterol (6-deoxoTY) to typhasterol (TY), but not castasterone (CS) to brassinolide (BL) .
Q43147
A5GI06
IF3_SYNPW
Translation initiation factor IF-3
unclassified Synechococcus
MPPRPRFDRRAPVRELPNINERINYPQLRVVDADGTQLGVIDREKALEVAQERELDLVLVSEKADPPVCRIMDYGKYKFEQEKKAKEAKKKSHQTEVKEVKMRYKIDQHDYDVRIGQAQRFLKAGDKVKCTVIFRGREIQHTALAETLLRRMAKDLEEPAEIQQPPKREGRNMIMFLTPRKTPLVKKDDKEEPATRAVRTITAPPRPTSARLASKPAGNG
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
A5GI06
B6HTQ4
MAP22_PENRW
Peptidase M
Penicillium chrysogenum species complex
MAAQTTEKLDQLDLNVQAAPTADQVPAEAEEDSDDAQDEGAAEAGAAGAGSTLADKKKKKKKPKKKSKKKGGAKVQSEPPRVPVSNLFPNGQYPEGEIVEYLNDNAYRTTNEEKRYLDRMNNDFLQEYRQGAEVHRQVRQYAQKNIKPGQTLTEIAEGIEDSVRALTGHSGLEEGDNIKGGMGFPCGLSINHCAAHYTPNAGNKMVLNEGDVMKVDFGAHLNGRIVDSAFTMTFDPVYDPLLAAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVEINGTMHPVKCIRNLNGHNIDQHVIHGGKSVPIVKSTDQTKMEEGEVFAIETFGSTGKGYVREEMETSHYALAADAPNVPLRLSSAKNLLNLINKNFGTLPFCRRYIDRLGQDKYLLGLNNLVSSGIVQDYPPLCDIKGSYTAQYEHVCFYFGVFSTLIVY
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
B6HTQ4
Q97TX8
DPHB_SACS2
Diphthamide biosynthesis methyltransferase
Saccharolobus
MSILSLVGLGISKKFITDSAIETLSNSDIIIFDRYTSRSCDINVDVLRRLVKGEREFIEADRSLLENNSKAIIDYLDKGYNVSIASIGDALIATTHVSLLIEAKHRGHEVKVIPGISVHCYLISKSLLSSYKFGKSVTVTFPYNDFIDPTPYNVIKDNKERGLHTILYLDLKNEKAMTANEALQILLRLEERHKKSVLSKSDIIIVGARLGCDDERIIALKVEEATSFDFGNTPHIIIIPGNLHYMEADAIKWILRS
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Q97TX8
Q4A6S7
KGUA_MYCS5
GMP kinase
Mycoplasmopsis
MNKKKKSIVIFTGPSGVGKGTVEQLVFNYDELNLSLSCSATTRSPRGGETNGIHYYFISKEEFKDRIKNKKFLEHSFHFDNYYGTLYSELDNIIARNKVPFLEIETNGAKIIAQKMQKLKNPPYNLITIFLSPPSITDIYKRIKNRGTENAQTIKNRVNKAKEELLEAGNFKYVVYNDRPERAAQEIREILHKELDID
Essential for recycling GMP and indirectly, cGMP.
Q4A6S7
A8EXA9
RL9_RICCK
50S ribosomal protein L9
belli group
MEIILIKPVRKLGKIGDILKVADGFGRNYLLPQKLAIRATEPNKELIVKQKHEFEAKDKQIREEVEKINALIKEQKLVFIRQTSDDGKLFGSITNKEIADKLSENVSYNIFHSNIILDKKIKSTGIYTVEIRLHAELNAIVTVIVARSESEVQDYLREQKNESLETLAESA
Binds to the 23S rRNA.
A8EXA9
Q1J7I7
EZRA_STRPF
Septation ring formation regulator EzrA
Streptococcus
MSSGIILLIVAIVLLVIIAYLVGVIIRKRNDSLITSLEERKQALFALPVNDEIEEVKSLHLIGQSQTSFREWNQKWVDLTVNSFADIENHIFEAENLNDTFNFIRAKHEINSVESQLNLVEEDIASIREALNILKEQEEKNSARVTHALDLYEKLQASISENEDNFGSTMPEIDKQMKNIETEFSQFVALNSSGDPVEASEVLDRAEEHTIALGQITEQIPAIVAKLEDDFPDQLDDLETGYRRLLEENYHFPEKNIEARFQEIRESIRANSSELVTLDLDRAREENTHIQERIDSLYEVFEREIAAYKVAAKNSKMLPRYLAHVKHNNEQLKDEIARLSRKYILSETESLTVKAFEKDIKEIEDSTLAVAEQFGLQEKPFSELQVTFERSIKTLTNVESGQMDVFAAVKDIEKIESQARHNLDVYVTQLHMIKRYMEKRHLPGIPQDFLSAFFTTSSQLEALMDELSRGRINIEAVSRLSEVATVAIANLEDLTYQVVQNATLTEQLLQYSNRYRSFEAGVQSSFEHALRLFEVENDYQASFDEISYALETVEPGVTDRFVNSYEKTREHIRF
Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.
Q1J7I7
B7L504
MHPB_ECO55
3-carboxyethylcatechol 2,3-dioxygenase
Escherichia
MHAYLHCLSHSPLVGYVDPAQEVLDEVNGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLYKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISTFGNWRSEGRYYRPIPEWIAGFGSLSARTEN
Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
B7L504
Q67SL8
SSRP_SYMTH
Small protein B
Symbiobacterium
MARAKAEIQPVAENRKARHDYFVEETYEAGIVLVGSEVKSCRAGRVNLRDAYAQIKDGEIFLLNCHISPFEQANRFNHEPLRPRKLLMHKSEIHRLYGKVREKGFTLVPLRLYFNQKGKVKVELALAKGKRAYDKRDDIAAREAKREMARALRGRYDD
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
Q67SL8
P01968
HBA2_BOSMU
Hemoglobin alpha-2 chain
Bos
VLSAADKGNVKAAWGKVGGHAAEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGAKVAAALTKAVGHLDDLPGALSELSDLHAHKLRVDPVNFKLLSHSLLVTLASHLPSDFTPAVHASLDKFLANVSTVLTSKYR
Involved in oxygen transport from the lung to the various peripheral tissues.
P01968
Q82F60
SYM_STRAW
Methionyl-tRNA synthetase
Streptomyces
MARHLITSALPYINGIKHLGNMVGSMLPADVYSRYLRQRGHDVLYICATDEHGTPAELAAKERGLPVDEFCAQAHDAQKAVYDGFELAFDYFGRSSSEQNREITQHFARRLNENGFIEERAIRQVYSPADGRFLPDRYVEGTCPHCGYDKARGDQCENCTRVLDPTDLINPRSAISGSTDLEVRETKHLFLLQSKLQHEVEEWVARHEEEWPQLASSIARKWLNEGLHDRAITRDLDWGVPVPADTWPELAAEGKVFYVWFDAPIEYIGATKEWSDLDPENRDWKSWWYDADSGENPVRYTEFMAKDNVPFHTVMFPATELGVREPWKKVDYVKAFNWLTYYGGKFSTSQKRGVFTDHALEILPADYWRYFLIANAPESDDSSFTWEHFTATVNKDLADTLGNFVNRVLSFSKKRFGEEVPAGAPAGESETKLGEEIAALLAEYESHMETLQFRKAAAALRALWSAGNSYLEEKAPWLEIKTNPEGAALTLRTAMNLIHLYSVVSEPFIPASSKAMRSAFALSEDTATWVTQDEAKSLDSVPAGTPFTVPPVLFAKITDEDLESYKERFGGAPE
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Q82F60
Q8NG76
O2T33_HUMAN
Olfactory receptor OR1-56
Homo
MEMRNTTPDFILLGLFNHTRAHQVLFMMVLSIVLTSLFGNSLMILLIHWDHRLHTPMYFLLSQLSLMDMMLVSTTVPKMAADYLTGSKAISRAGCGVQIFFLPTLGGGECFLLAAMAYDRYAAVCHPLRYPTLMSWQLCLRMTMSCWLLGAADGLLQAVVTLSFPYCGAHEIDHFFCETPVLVRLACADTSVFENAMYICCVLMLLVPFSLILSSYGLILAAVLHMRSTEARKKAFATCSSHVAVVGLFYGAAIFTYMRPKSHRSTNHDKVVSAFYTMFTPLLNPLIYSVKNSEVKGALKRWLGTCVNIKHQQNEAHRSR
Odorant receptor.
Q8NG76
Q2I3G8
COX3_ELEMA
Cytochrome c oxidase polypeptide III
Elephas
MTHQMHAYHMVDPSPWPLTGALSALLMTSGLTMWFHYHSVILLLLGLTTNILTMFQWWRDVVREGTFQGHHTPIVQESLRYGMILFITSEVLFFTGFFWAFYHSSLAPTPELGSYWPPVGVYPLNPLEVPLLNTSVLLASGVTITWAHHSLMEGSRKNMLQALLITILLGVYFTLLQMFEYYEASFTISDGIYGSTFFVTTGFHGLHVIIGSTFLLICFIRQLKFHFTSNHHFGFEAAAWYWHFVDVVWLFLYLSIYWWGS
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Q2I3G8
Q329V7
GPPA_SHIDS
pppGpp-5'-phosphohydrolase
Shigella
MGSTSSLYAAIDLGSNSFHMLVVREVAGSIQTLTRIKRKVRLAAGLNSENALSNEAMERGWQCLRLFAERLQDIPPSQIRVVATATLRLAVNAGDFIAKAQEILGCPVQVISGEEEARLIYQGVAHTTGGADQRLVVDIGGASTELVTGTGAQTTSLFSLSMGCVTWLERYFADRNLGQENFDAAEKAAREVLRPIADELRYHGWKVCVGASGTVQALQEIMMAQGMDERITLEKLQQLKQRAIHCGRLEELEIDGLTLERALVFPSGLAILIAIFTELNIQYMTLAGGALREGLVYGMLHLAVEQDIRSRTLRNIQRRFMIDIDQAQRVAKVAANFFDQVENEWHLEAISRDLLISACQLHEIGLSVDFKQAPQHAAYLVRNLDLPGFTPAQKKLLATLLLNQTNPVDLSSLHQQNAVPPRVAEQLCRLLRLAIIFASRRRDDLVPEMTLQANHELLTLTLPQGWLTQHPLGKEIIAQESQWQSYVHWPLEVH
Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
Q329V7
P57110
ATS8_MOUSE
METH-2
Mus
MLRDPTTTGWPPLLLLLLQLPPPPLVCGAPAGPGTGAQASELVVPTRLPGSASELAFHLSAFGQGFVLRLAPDASFLAPEFKIERLGGSSAAAGGEPGLRGCFFSGTVNGERESLAAMSCVAGWSGSFLLAGEEFTIQPQGAGDSLDQPHRLQRWGPGQRREDPGLAAAEVFPLPQGLEWEVEMGNGQGQERSDNEEDRKQDKEGLLKETEDSRKVPPPFGSKTRSKRFVSEARFVETLLVADASMAAFYGTDLQNHILTVMSMAARIYKHPSIRNSVNLVVVKVLIVEKERWGPEVSDNGGLTLRNFCSWQRRFNKPSDRHPEHYDTAILFTRQNFCGKGEQCDTLGMADVGTICDPDKSCSVIKDEGLQAAYTLAHELGHVLSMPHDDSKPCVRLFGPMGKYHMMAPFFIHVNKTLPWSPCSAVYLTELLDDGHGDCLLDAPTSVLPLPTGLPGHSTLYELDQQCKQIFGPDFRHCPNTSVEDICVQLCARHRDSDEPICHTKNGSLLWADGTPCGPGHLCLDGSCVLKEDVENPKAVVDGDWGPWRPWGQCSRTCGGGIQFSNRECDNPMPQNGGRFCLGERVKYQSCNTEECPPNGKSFREQQCEKYNAYNHTDLDGNFLQWVPKYSGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPDTLSICVRGQCVKAGCDHVVNSPKKLDKCGVCGGKGTACRKISGSFTPFSYGYNDIVTIPAGATNIDVKQRSHPGVRNDGSYLALKTANGQYLLNGNLAISAIEQDILVKGTILKYSGSMATLERLQSFQALPEPLTVQLLTVSGEVFPPKVRYTFFVPNDMDFSVQNSKERATTNIIQSLPSAEWVLGDWSECPSTCRGSWQRRTVECRDPSGQASDTCDEALKPEDAKPCGSQPCPL
Has anti-angiogenic properties.
P57110
A6H7F2
GPN2_BOVIN
ATP-binding domain 1 family member B
Bos
MAGAAPTTAFGQAVIGPPGSGKTTYCLGMSEFLRALGRRVAVVNLDPANEGLPYECAVDVGELVGLGDVMDALQLGPNGGLLYCMEYLEANLDWLRAKLDPLRGHYFLFDCPGQVELCTHHGALRSIFSQMTQWDLRLTAVHLVDSHYCTDPAKFISVLCTSLATMLHVELPHVNLLSKMDLIEHYGKLAFNLDYYTEVLDLSYLLDHLASDPFFRHYRQLNEKLVQLIEDYSLVSFIPLNIQDKESIQQVLQAVDKANGYCFGVQEQRSLEAMMSAAMGADFHFSSTLGLQEKYLAPSEQSVEQEAMQL
Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.
A6H7F2
P70773
ARGP_AERSA
HTH-type transcriptional regulator ArgP
Aeromonas
MKALDYKLLLALDAVMQEQNFERAAQRLHITQSAISQRIKQLEQQFAEPLLIRSQPLQATPLGQKLLAHYRQVRQLELELAGEIAPDEPQAPIRVSIAVNADSLATWFLPALAPLLEQHPIELNLLVDDECRTLDRVREGQAFGAVSLHGQPLAGCCVDELGEMRYLLTASPAFVARHFPAGLTPAALAKTPAVAFDQRDDMHVSFMARHFGLEPGGYPCHTVRSSEAFVAMAEQGLAYCLIPELQIRQQLAQGILLDLSPSHHLIEPLYWHRWVLERGLHKQISQRLISEGRRALQPG
Controls the transcription of genes involved in arginine and lysine metabolism.
P70773
Q5E3N1
FLGI_ALIF1
Basal body P-ring protein
Aliivibrio
MTNRWSFDVNKNLVTVLFTWLCLSISTAHAARIKDVAEVAGVRSNQLIGYGLVSGLPGTGESTPFTDQSFNAMLQNFGIQLPPGTKPKTKNVAAVMVTATLPPFSKQGQVVDVTVSSVGSAKSLRGGTLLQTFLKGLDGKTYAIAQGNLIVSGFSATGADGSKIVGNNPTVGRISGGAMVEREVPSPFGRGDFITFNLLESDFTTAQRMADAVNNFLGPNMASAVDATSVRVRAPRDISQRVAFLSAVENVDFDPADGSAKIIVNSRTGTIVVGKHVKLKPAAVTHGGMTVAIKENLQVSQPGPFSDGQTVVTPDSDIEVTEEQGKMFKFEPGLTLDDLVRAVNEVGAAPSDLMAILQALKQAGAIEGQLIII
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
Q5E3N1
Q9CJU2
PSD_PASMU
Phosphatidylserine decarboxylase beta chain
Pasteurella
MNILEKKAQLSYWQRIKIAFQYVMPQLYLTRLAGWFAKQQWGAVTHFVIKLFAKKYHVDMSEAAKPNFSDYASFNEFFIRPLADNARPINQNPTALCLPADGRISQLGHIEQDLLLQAKGHYFSLNDLLAGDEALAHHFKDGEFATTYLSPRDYHRVHMPCDATLCKMIYVPGDLFSVNPFLAEHVPNLFARNERVICVFDTEFGKMVQILVGATITASMSTVWAGVINPPRPEKITTWTYEGASAVKLTKGQEMGAFQLGSTVINLFEKDRVQLASHLQVDSPVRMGEILAHQK
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
Q9CJU2
B1I1K1
RS14Z_DESAP
30S ribosomal protein S14 type Z
Candidatus Desulforudis
MAKKSLIEKANRPPAFRVRQYNRCKLCGRPRAYMRKFGVCRICFRSLCYRGQIPGVRKASW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
B1I1K1
P86970
LECG_BOTPA
C-type lectin BpLec
Bothrops
NNCPQDWLPMNGLCYKIFDELKAWKDAEMFCRKYKPGCHLASIHLYGESPEIAEYISDYHKGQSEVWIGLWDEKKDFSWEWTDRSCTDYLSWDKNQPDHYKNKEFCVELVSYTGYRLWNDQVCESKNAFLCQCKF
This lectin displays hemagglutinating activity on dog (128'000 HU/mg) and cat erythrocytes, that is inhibited by beta-galactosides (D-galactose, D-lactose, and N-acetyl-D-galactosamine) and EDTA. In addition, has been shown to hemagglutinate promastigote forms of Leishmania amazonensis. Also inhibits Gram-positive (S.aureus ATCC 25923) (MIC is 31.25 ug/ml) but not Gram-negative (E.coli ATCC 25922) bacteria. Is a calcium-dependent lectin.
P86970
Q9Z275
RLBP1_MOUSE
Cellular retinaldehyde-binding protein
Mus
MSDGVGTFRMVPEEEQELRAQLEQLTTKDHGPVFGPCSQLPRHTLQKAKDELNEKEETREEAVRELQELVQAQAASGEELALAVAERVQARDSAFLLRFIRARKFDVGRAYELLKGYVNFRLQYPELFDSLSMEALRCTIEAGYPGVLSSRDKYGRVVMLFNIENWHCEEVTFDEILQAYCFILEKLLENEETQINGFCIVENFKGFTMQQAAGLRPSDLKKMVDMLQDSFPARFKAIHFIHQPWYFTTTYNVVKPFLKNKLLQRVFVHGDDLDGFFQEIDENILPADFGGTLPKYDGKVVAEQLFGPRAEVENTAL
Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
Q9Z275
Q2H988
SET2_CHAGB
SET domain-containing protein 2
Chaetomium
MSPDDAKSAADGTSVPENGTAPKLSRKPSQKLPRGPPPLFDHLPDATADACDTFQVINDCLYGSKNMGSSDHDALDCDCAEEWHDGQNHACGEDSDCINRATKIECVSGDCNCGEGCENQRFQRKQYANVSVIKTEKKGFGLRTDADLQANDFVFEYVGEVINEPTFRNRTVKYDKEGIKHFYFMSLTKSEFVDATKKGNLGRFCNHSCNPNCYVDKWVVGDKLRMGIFATRAIRAGEELVFNYNVDRYGADPQPCYCGESNCVGFIGGKTQTERATKLPLATIEALGIDDGDSWDTAVAKKPRKKKAHEDDEDYVNSVQPRALDEDGVNKVMATLMQCKEKWIAVKLLSRLQATEDEHLRHRVVRMHGYQILKTTLNTFKDDTNVVLQILDILYQLPRITKNKISDSKVEGAVEPLASAAHEEVALAAKRLLDEWSKLETAYRIPRKKHDHAGPIPGNSFEEERRNKDREEPAKPTDPFANIVIPTGPRSTIPQRNANFFAGQQRPRKPPTNLPAGWFVNTDKTGRYYFYDATGRTQWQRPLTPAIETPKVSAKAQQDQKALQSIIDSLTKEPTPRHSAGHTPQRSTTPATEPKKDKWRSLPLEKQMKIYENTHVVDRFHGKLPKEELKKFAREVNKKLVSSDYKNNRVEDPTSIPPKQAKKVRKYAHDFFDRAVAKYTEHEKKKAHNPSKPTSGVPPGDVASSAATPAKDDVTMSDVEADTSPGSSAGRKRKRDGDDEHDDPAESPGAPPSETPSVKRIKEDDAEGEGEPTTIPPPPTPPPPPADTPPTEEDRSMREQEEALMRENEEAQRLEDEAQAEEGGKGSHEWNGRYHRTCAAGERAVEWRVGNGWCYGDDGHGRAAATTAAAAATAAAGSAGSLKTTLACFAFAPC
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.
Q2H988
Q2T0H6
DUT_BURTA
dUTP pyrophosphatase
pseudomallei group
MKLDLKILDARMRDYLPKYATTGSAGLDLRACLDAPVTLKPGDTALVPTGLAIHLADPGYAALILPRSGLGHKHGIVLGNLVGLIDSDYQGELMISTWNRGQTEFVLNPFERLAQLVIVPVVQATFNIVGDFAQSDRGAGGFGSTGRH
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Q2T0H6
B4G9X6
EIF3K_DROPE
eIF-3 p25
Sophophora
MSHLVKMENGQSQTIQEMLGCIERYNPDHLKTLEAYIQDQAKNNTYDLEANLAVLKLYQFNPHMLNFEITYTILLKSLTNLPHTDFVMAKCLLLPQQMKDENIQTIIDLADILERADFTLFWQRAEVNRTMFRHISGFHDSIRKFVSHVVSITFQTIKKDLLKELLGGIEDSTLESWIKRNGWKHQGQDLIVVAMQDDKIKTKNITEKIEFENVGALMAQCL
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
B4G9X6
O27197
FKBPL_METTH
Rotamase
Methanothermobacter
MAVNKGDFIKIEFTGKVKETGEVFDTTYEEVAREAGLGIKKIFGPIPVVVGGGHLIKGLDEAVIGMEEGEEKHVEIEPEDAFGNRDPKLVQLIPMGEFKRQGIKPYPGMTLTVEGHEGRVLNVSGGRVRVDFNHELAGKTLEYDLKVKEIITDDAEKVKSMIQLHYPSQNMDIDKTEVKIEDGKVIIHMDEMTRFDNRSYMDVTLARFRIARDIWENIEGVEKVEFADVFEKRDMEAEEKEEEVEDAGED
Catalyzes the cis-trans isomerization of peptidyl prolyl bonds and accelerates protein folding. Also exhibits chaperone-like activity . In vitro, can use oligopeptides such as N-succinyl-Ala-Leu-Pro-Phe-p-nitroanilide and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as substrates. The PPIase activity is much lower than those of other FKBPs reported against oligopeptidyl substrates. As a chaperone, protects green fluorescent protein (GFP) and rhodanese from thermal denaturation or aggregation, and suppresses the aggregation of chemically unfolded rhodanese and elevates the yield of its refolding .
O27197
O75154
RFIP3_HUMAN
MU-MB-17.148
Homo
MASAPPASPPGSEPPGPDPEPGGPDGPGAAQLAPGPAELRLGAPVGGPDPQSPGLDEPAPGAAADGGARWSAGPAPGLEGGPRDPGPSAPPPRSGPRGQLASPDAPGPGPRSEAPLPELDPLFSWTEEPEECGPASCPESAPFRLQGSSSSHRARGEVDVFSPFPAPTAGELALEQGPGSPPQPSDLSQTHPLPSEPVGSQEDGPRLRAVFDALDGDGDGFVRIEDFIQFATVYGAEQVKDLTKYLDPSGLGVISFEDFYQGITAIRNGDPDGQCYGGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETFTDEDTSTLVHPELQPEGDADSAGGSAVPSECLDAMEEPDHGALLLLPGRPHPHGQSVITVIGGEEHFEDYGEGSEAELSPETLCNGQLGCSDPAFLTPSPTKRLSSKKVARYLHQSGALTMEALEDPSPELMEGPEEDIADKVVFLERRVLELEKDTAATGEQHSRLRQENLQLVHRANALEEQLKEQELRACEMVLEETRRQKELLCKMEREKSIEIENLQTRLQQLDEENSELRSCTPCLKANIERLEEEKQKLLDEIESLTLRLSEEQENKRRMGDRLSHERHQFQRDKEATQELIEDLRKQLEHLQLLKLEAEQRRGRSSSMGLQEYHSRARESELEQEVRRLKQDNRNLKEQNEELNGQIITLSIQGAKSLFSTAFSESLAAEISSVSRDELMEAIQKQEEINFRLQDYIDRIIVAIMETNPSILEVK
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) .
O75154
P51685
CCR8_HUMAN
TER1
Homo
MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.
P51685
Q44685
TRPB_BUCAI
Tryptophan synthase beta chain
Buchnera
MTLLNPYFGEFGGMYVPQILMPALFELEKNFVSAQKDAEFQKKFFYLLQNYAGRPTPLTLCKNLTKGTKTKIYLKREDLLHGGAHKTNQVLGQAMLAIRMKKKEIIAETGAGQHGVASAIACALFNLKCRIYMGIKDIKRQNTNVFRMKLMGAEVISVKNGSGTLKDACNEALRDWSSSYKKSHYMIGTAAGPHPYPTIVREFQKMIGEETKKQILEKENKLPDSIIACIGGGSNAIGIFSDFINDKVNLIGVEPAGYGIHTGKHGAPLKHGRTGIYFGMKSHLMQNKQGQIQESWSISAGLDFPSVGPEHAWLNSINRAKYVSITDEEAISAFQVLSRKEGIIPALESSHALAYALKLMKKDPTIEQILIANLSVVEIKIFLQYMMF
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Q44685
Q54465
MERA_SHEPU
Hg(II) reductase
Shewanella
MILLSIEGMTCPSCVAHVKEALDAIEGVNKVEISYENARATITTNGGVSVTVLIGAIEALGYIAKESTGTAKEITSPNDCCDNENASNTESNQTQHVAIIGTGSGAFACAIKAAEGGAKVTLIEGADVIGGCCVNVGCVPSKILIRAAQLAQQQRNNPFTGLENHAPQLSRALLTQQQTARVEELRAAKYQNILETNPALSLLKGWAQFKNANTLIVRKNDGTEQAVHADKILIATGSTPTIPPIDGLTETPYWTSTEALFAQELPQHLVVIGSSVVALEIAQAYRRLGSEVTILARHTLLYREDPLLGEKLTGCFEKEGIRVLNSTQATKVTHDGSQFTLETNAGDLRCDRLLVSTGRHANTCQLNLGAVGVTTNKKGEIVVNERMETNVPGIYAAGDCCNMPQFVYVAAAAGSRSGINMTGGYAKLDLSTMPAVIFTDPQVATVGLTEEQANAQDIETDSRVLEMENVPRALANFETDGFIKLVTEKATGRLIGAQILAHEGGELIQSAALAIRNRMTVTELADQLFPYLTMVEGLKLCAQTFNKDVKELSCCAG
Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).
Q54465
A9B5N1
LON1_HERA2
ATP-dependent protease La 1
Herpetosiphon
MSEVERTTTIPDEIAILPLLGTVAYPQTIMPLAIGQPESIRLIDDLMAGQRIVGLMALKNEDERPNPVLPEDFYQLGSAAVVHKLMKLPDGTLRAAMQVLERIEIVEIIQTEPYYRAKIRVMPDALAESEQLEVTALMRSIGTIASQIAPLIPQFPTELLNSVLSEEDPRRLAYLVASYARMSVTDRQAVLAEPSIKQKLLKLNEVLTRELNVLQIGQQIQSQVQDEMSKTQREYVLREQLKAIRKELGENNEQEVEVDRLAEQIEAAGMSAEAHQQAMRELDRLRQMPTAAAEYSVIRGYLETLIALPWQKRSDDTIDVAQATEVLDADHYGLDEIKERILDYLAVRELRRKRSPERDPGRGAILCFVGPPGVGKTSLGRSIAKAMNREFVRLSLGGVHDEAEIRGHRRTYIGAMPGSLIQAIRRSGVNNPVVLLDEIDKLSSDHRGDPTSAMLEVLDPAQNTNFRDHYLDVAWDLSPVMFIATANTLQTIPAPLRDRLEIIQLGSYTMREKYEIASRYLVPEQREQHSLAPNEVEIDHEALLVAIEEYTREAGVRNLEQQIGTLMRKAARQVALGSATPIVLDPAKTREYLGKRRYFSEIHERTDRPGIVTGLVWTPVGGDIIFIEATKMTGRGNFALSGQLGDVMKESARAALSWVRAEGEAYGIDPNFAQHYDLHVHVPAGAQPKDGPSAGIAMATALVSLLTGRVLRDDVAMTGEITLRGKVLPIGGVREKVLAAHRAGIRTIILPQRNLADLDEIPADVLAEVQFHGVEHVGQVIELALRAEASEAPVSVPESAVMPNLFQSDVEVLVH
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
A9B5N1
P63638
MURI_STAAN
Glutamate racemase
Staphylococcus
MNKPIGVIDSGVGGLTVAKEIMRQLPNETIYYLGDIGRCPYGPRPGEQVKQYTVEIARKLMEFDIKMLVIACNTATAVALEYLQKTLSIPVIGVIEPGARTAIMTTRNQNVLVLGTEGTIKSEAYRTHIKRINPHVEVHGVACPGFVPLVEQMRYSDPTITSIVIHQTLKRWRNSESDTVILGCTHYPLLYKPIYDYFGGKKTVISSGLETAREVSALLTFSNEHASYTEHPDHRFFATGDPTHITNIIKEWLNLSVNVERISVND
Provides the (R)-glutamate required for cell wall biosynthesis.
P63638
C1DLI3
RIBA_AZOVD
GTP cyclohydrolase II
Azotobacter
MSVVFVAASKLPTPFGVFTMHGFLDEATGKEHVALTLGTVDDGAPVLGRLHSECLTGDALFSLRCDCGFQLEAALRAIAAEGRGVLLYLRQEGRGIGLLNKIRAYKLQDAGADTVEANERLGFRADQRDYGICKPMLEHLGITAIKLMTNNPRKVKALEGAGIQVTERVPLQTGLNPHNQKYLATKAGKLGHLLGSLHQGEVETPTGS
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
C1DLI3
Q9C5W3
NADK2_ARATH
NAD kinase 2, chloroplastic
Arabidopsis
MFLCFCPCHVPIMSRLSPATGISSRLRFSIGLSSDGRLIPFGFRFRRNDVPFKRRLRFVIRAQLSEAFSPDLGLDSQAVKSRDTSNLPWIGPVPGDIAEVEAYCRIFRSAERLHGALMETLCNPVTGECRVPYDFSPEEKPLLEDKIVSVLGCILSLLNKGRKEILSGRSSSMNSFNLDDVGVAEESLPPLAVFRGEMKRCCESLHIALENYLTPDDERSGIVWRKLQKLKNVCYDAGFPRSDNYPCQTLFANWDPIYSSNTKEDIDSYESEIAFWRGGQVTQEGLKWLIENGFKTIVDLRAEIVKDTFYQTALDDAISLGKITVVQIPIDVRMAPKAEQVELFASIVSDSSKRPIYVHSKEGVWRTSAMVSRWKQYMTRPITKEIPVSEESKRREVSETKLGSNAVVSGKGVPDEQTDKVSEINEVDSRSASSQSKESGRFEGDTSASEFNMVSDPLKSQVPPGNIFSRKEMSKFLKSKSIAPAGYLTNPSKILGTVPTPQFSYTGVTNGNQIVDKDSIRRLAETGNSNGTLLPTSSQSLDFGNGKFSNGNVHASDNTNKSISDNRGNGFSAAPIAVPPSDNLSRAVGSHSVRESQTQRNNSGSSSDSSDDEAGAIEGNMCASATGVVRVQSRKKAEMFLVRTDGVSCTREKVTESSLAFTHPSTQQQMLLWKTTPKTVLLLKKLGQELMEEAKEAASFLYHQENMNVLVEPEVHDVFARIPGFGFVQTFYIQDTSDLHERVDFVACLGGDGVILHASNLFKGAVPPVVSFNLGSLGFLTSHPFEDFRQDLKRVIHGNNTLDGVYITLRMRLRCEIYRKGKAMPGKVFDVLNEIVVDRGSNPYLSKIECYEHDRLITKVQGDGVIVATPTGSTAYSTAAGGSMVHPNVPCMLFTPICPHSLSFRPVILPDSAKLELKIPDDARSNAWVSFDGKRRQQLSRGDSVRIYMSQHPLPTVNKSDQTGDWFRSLIRCLNWNERLDQKAL
Involved in chlorophyll synthesis and chloroplast protection against oxidative damage.
Q9C5W3
Q93JG0
SEPF3_STRCO
Cell division protein SepF 3
Streptomyces albidoflavus group
MKSGEPVNSHDVTDEQWEGLAQVVPLRGRDAWPSAVGHRAMPEAETERRRRFVVLRINVFADAREVAETLMAGIPVLLDLTSAEGEVAKRVLDFSTGVVFGLASGMHRVDRNVFLLTPAGTEVNGLMESAAGVPGV
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
Q93JG0
A1U2Y6
RL19_MARN8
50S ribosomal protein L19
Marinobacter
MSGKNNIISQLEAEQMTKEIPAFAPGDTVVVQVRVTEGNRERLQAFEGVVIGKRNRGMNSSFTVRKISYGVGVERTFQTYSKLIDSVSVKRRGDVRQAKLYYLRDLSGKAARIKEKLN
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
A1U2Y6
Q5ZT17
SODC_LEGPH
Superoxide dismutase [Cu-Zn]
Legionella
MNKSGIILIGTILFSSMAIADDLTAPIYTTGPKPVAIGKVTFTQTPYGVLITPDLTNLPEGPHGFHLHKTADCGNHGMHAEGHYDPQNTNSHQGPYGNGHLGDLPVLYVTSNGKAMIPTLAPRLKLSDMHNLAVMIHANGDTYSDNPPQGGGGDRIACGVIK
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Q5ZT17
O46262
HUNB_DRODA
Protein hunchback
split tarsi subgroup
WYSSMFAANIKQEPISHHHHHHHAHHSHHAHDSNSNSNASSPHQSPLPSPNPPSHTNLQLEQYLKQQQQQQQQHQHQQQQQPMDTLCAAAMTPSPSNNDQNSLGWLVGLPNPMQTIMPANMRPSPTATTATAAAAAPTTTAAAIALQANDKLQALTPPMDVTPPKSPAKSQQSCAEPEKEHDLMSNSSEDMKYMA
Gap class segmentation protein that controls development of head structures.
O46262
Q5LWL4
IF2_RUEPO
Translation initiation factor IF-2
Ruegeria
MSDTDGKKTLGLRGSRPGNVKQSFSHGRTKNVVVETKRKRVVVPKPGAGKPSAGGSSPAGDPSRRPAGISDAEMERRLNALKAAKARESEEAAQREAEEKARAEERERRRAEQEAKEREQREAEQRAREKAEEEERQRREAEEEAKRAAVRAAAEQEAPKAERSAERAPAAARPEGGDNARRTTDRDREREQRQTRGKGRQDGRRSGKLTLSQVTDGEGGRQKSLAAMKRKQERARQKAMGGAAEREKVIREVQLPEAIVVSELANRMAERVADVVKELMKMGMMVTQNQTIDADTAELIIEEFGHKVVRVSDSDVEDVISDIEDAEEDLKPRPPVITIMGHVDHGKTSLLDAIRDAKVVAGEAGGITQHIGAYQVKTDGGATLSFLDTPGHAAFTSMRSRGAQVTDIVVLVVAADDAVMPQTVEAINHAKAAGVPMIVAINKIDKPEANPTKVRTDLLQHEVVVEAMSGEVQDVEVSAKTGEGLDELLEAIALQAEILELKANPDRPAQGAVIEAQLDVGRGPVATVLIQKGTLRQGDIFVVGEQYGKVRALINDKGERVSEAGPSVPVEVLGLNGTPEAGDVLNVTSTEAQAREIAEYRAQVAKDKRAAAGAATTLEQLMAKAKADENVAELPILVKADVQGSAEAIVQAMEKIGNDEVRVRVLHSGVGAITETDVGLAEASGAPIMGFNVRANASARNTANQKGVEIRYYSVIYDLVDDVKAAASGLLSAEIRENFIGYANIKEVFKVSNVGKVAGCLVTEGVARRSAGVRLLRDNVVIHEGTLKTLKRFKDEVAEVQSGQECGMAFENYDDIRPGDVIEIFEREEVTRTLT
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Q5LWL4
Q9JYS8
DPO4_NEIMB
DNA polymerase IV
Neisseria
MSSRKIIHIDMDAFYASVELREQPHLKGRPVVVAWEGARSVICAASYEARQFGLHSAMSVATAKRLCPQAVYVPPHFDLYRQVSAQIHAVFRRYTDLIEPLSLDEAYLDVTRNFKNIPYAGDVAKEIRAAIFAETGLTASAGIAPNKFLAKIASDWRKPNGQFVLPPHKVMAFLETLPLGKIPGVGKVTLKKMQSLGMRTAGDLRRFERGELLNHFGRYGYRLYDLVRGTDERPVKAERERLQISTEITLPEDLPLEQAAGHLPHLAEDLWRQITRKNVEAQSVTLKLKTYDFRIITRTLTYSSVLPDCALCCRLRKC
Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
Q9JYS8
Q1GGM0
PURQ_RUEST
Phosphoribosylformylglycinamidine synthase subunit I
unclassified Ruegeria
MKAAVVVFPGSNCDRDLAVAFEQAGFDVSMVWHKDSELPEGVDIVGVPGGFSYGDYLRCGAIAAQSPICKAVVAHAERGGYALGVCNGFQILTETGVLPGALLRNAGLKYICKTVDLAVATSDSAFTQGYNAGDVIGVPIAHHDGNYYADDATVQMLKDQDRVAFTYVDNPNGSVADIAGILSENRRVLGMMPHPERAADEGHGGTDGVAMFRALSGLLTDA
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Q1GGM0
Q9QXF8
GNMT_MOUSE
Glycine N-methyltransferase
Mus
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCHRVLDVACGTGVDSIMLVEEGFSVMSVDASDKMLKYALKERWNRRKEPSFDNWVIEEANWLTLDKDVLSGDGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRPGGLLVIDHRNYDYILSTGCAPPGKNIYYKSDLTKDITTSVLTVNNKAHMVTLDYTVQVPGTGRDGSPGFSKFRLSYYPHCLASFTELVRAAFGGRCQHSVLGDFKPYKPGQAYVPCYFIHVLKKTD
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate . Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine .
Q9QXF8
A1USR6
RS13_BARBK
30S ribosomal protein S13
Bartonella
MARIAGVNIPTNKRLVIALQYIHGIGEKFAHKIIEKVGIPAERRVHELSDSEILQIRETIDRDYQVEGDLRREVAMSVKRLMDLGCYRGLRHRRSLPVRGQRTHTNARTRKGPARAIAGKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
A1USR6
Q6LWN2
DGGGP_METMP
Geranylgeranylglycerol-phosphate geranylgeranyltransferase
Methanococcus
MDIKAYFELIRLKNCLTASFGAFIGGLIASYFNLAMVDNLILASIVVFLVCGFGNALNDIYDLKIDRINKPKRPIPSKRITLNNAKVFSYSLVVMGLFISLFNISCFLMAVLNSIVLQQYASTYKKNKIIGNLIVAYLTGSVFIFGGIAVGNIDVTIMLFLCALFAMWSREIIKDYEDIEGDLKEKVISIPIKCGERSIYIAAFLLIFAIFLSPLPYLFGFFGIYYMISVVFCDLLFLFGIYKLVFNPSKMEAKKASRNIKIVTNLVLIAFLIGSLFK
Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.
Q6LWN2
Q31PU7
COFG_SYNE7
FO synthase subunit 1
Synechococcus
MKHFSDQTWRSPQQSAVITYSPAYTLVPTYECFNRCTYCNFRRDPGMDEWLSLSTAQQRLLTVRDRGVCEVLILSGEVHPQSPRRAAWRQRLIELAELALDMGFLPHTNAGPLNRAEMIALQNVNVSLGLMLEQLTPQLQRTVHRAAPSKDPQLRLQQLEQAGELGIPFTTGLLLGIGETSRDRLETLEAIAACHDRWGHIQEVILQPHSPGRQQAIQHPPLAPDELIDCVAIARQVLPTSIAIQVPPNLLTQPQQLADCLGAGARDLGGIVPYDEVNPDYQHHDLDELREALAQQGWQLQPRLPVYPHLVDRLPQRLQTHVAAWLNRFNSQSRSS
Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin from 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil.
Q31PU7
Q9M5P3
CCDA_ARATH
Cytochrome b6f biogenesis protein CCDA
Arabidopsis
MNLSVNRCITGGFVGGFSSCRLNHEKRWVRAGKHCELERERSLVSDAVSLERLESKSIKLAMLASGLGVANLVTLSSAKAADLKMIVLDQATSIYILAEGSLGDSVGNFLYSANQQANEAVQDQLSALSVTSLAVIFGAGLVTSLSPCTLSVLPLTLGYIGAFGSGKSRGQVIGDTVAFALGLATTLALLGIVASFAGKAYGQIGQGLPVAASGLAIVMGLNLLEIIELQLPSFFNNFDPRAAAANFPSSVQAYLAGLTFALAASPCSTPVLATLLGYVATSRDPVIGGSLLLTYTTGYVAPLIVAASFAGALQSLLSLRKVSAWINPISGALLLGGGLYTFLDRLFPAATMVM
Required for the transfer of reducing equivalents from stroma to thylakoid lumen. Involved in the biogenesis of the plastid cytochrome b6f complex by probably transferring reducing equivalents from stromal m-type thioredoxin (Trx-m) to the lumenal thioredoxin HCF164.
Q9M5P3
B1KHY4
ALR_SHEWM
Alanine racemase
Shewanella
MKPFPRAEISAQALKNNLSRLRQIAPNSSVMAVVKANGYGHGLLNVASCLTEADGFGLARLEEALALRAGGVKAKLVLLEGFFRQVDLTTLVEHGIDTVIHNEVQLDMLENASLSKPVTVWLKLDSGMHRLGFTPEQFAQVYARLEACPQVAKPINIMSHFACADEPDNPMTQEQLQVFEALTKNSKGYRTLANSAGTLYWPDSQADWIRPGIALYGVSPVIGDLGRNHGLEPAMKLVSQLIAVREHKAGQPVGYGCFWHAKADTRLGVVAIGYGDGYPRNAPEGTPVWVNGRRVPVVGRVSMDMLTVDLGIDAKDSIGDDVVLWGKELPVEEVAEHIGTIAYELVTKLTPRVAVCLD
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
B1KHY4
C0HLJ6
CO1A2_MEGAE
Alpha-2 type I collagen
Megatherium
SGGFDFSFLPQPPQEKDGGRYYGVGLGPGPMGLMGPRGPPGASGAPGPQGFGPAGEPGEPGQTGPAGARGPPGAPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGELGPVGNTGPSGPAGPRGEQGLPGVSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGASGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGSSGEEGKRGPNGESGSTGPTGPPGLRGNPGSRGLPGADGRAGVIGPAGARGASGPAGVRGPSGDTGRPGEPGLMGARGLPGSPGNVGPAGKEGPAGLPGIDGRPGPIGPAGARGEAGNIGFPGPKGPAGDPGKAGEKGHAGLAGNRGAPGPDGNNGAQGPPGPQGVQGGKGEQGPAGPPGFQGLPGPAGTTGEAGKPGERGIPGEFGLPGPAGPRGERGPPGESGAVGPSGAIGSRGPSGPPGPDGNKGEPGVVTAGPAGSGGLPGERGAAGIPGGKGEKGETGLRGEVGTTGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGTKGPKGENGIVGPTGPVGSAGPAGPNGPAGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGITGPPGPPGAAGKEGLRGPRGDQGPVGRTGETGAGGPPGFTGEKGPSGEPGTAGPPGTAGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPSGAVGPGVNGAPGETGRDGNPGSDGPPGRDGLPGHKGERGYAGNAGPVGAAGAPGPHGTVGPAGKHGNRGEPGPVGSVGPVGALGPRGPSGPQGIRGDKGEPGDKGPRGLPGLKGHNGLQGLPGLAGQHGDQGSPGPVGPAGPRGPAGPSGPAGKDGRTGHPGAVGPAGIRGSQGSQGPSGPPGPPGPPGPPGASGGGYDFGYEGDFYRA
Type I collagen is a member of group I collagen (fibrillar forming collagen).
C0HLJ6
C3P9L3
HSLO_BACAA
Heat shock protein 33 homolog
Bacillus cereus group
MKDYLVKALAFDGEVRAYSVRTTNTVSEAQRRHDTWRTASAALGRSLTAGTMMGAMLKGDQKLTIKVEGNGPIGPILVDAHANGDVRGYVTNPHVDFEGTEQGKLRVYQAVGTEGFVTVIKDIGMREPFIGQSPIVSGELGEDFTYYFAVSEQTPSSVGVGVLVNGDDSILAAGGFILQIMPGAQEETISFIEERLQKIPPVSTLIEQGLSPEELLYAVLGEDKVKVLETMDVQFNCTCSRERIESVLISLGKTELEQVREEEEETEVHCHFCNERYKFSKEDITNLIENL
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
C3P9L3
Q089W9
MOAC_SHEFN
Molybdenum cofactor biosynthesis protein C
Shewanella
MSNCFTHINADGNAHMVDVTEKAVTEREARAEAFIDMAPDTLAMIMNGSHHKGDVFATARIAGIQAAKKTSDLIPLCHPLMLTKVEVELEAQPEHNRVRITSLCKLSGKTGVEMEALTAASVAALTIYDMCKAVQKDMIISQVRLLEKRGGKSGHFKA
Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).
Q089W9
Q2NQP5
RS11_SODGM
30S ribosomal protein S11
Sodalis
MAKAPIRARKRVKKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCAEAVKEYGIKNLEVVVKGPGPGRESTVRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Q2NQP5
Q2KAC2
PSD_RHIEC
Phosphatidylserine decarboxylase beta chain
Rhizobium
MSLFNTVRNTIVPVHKEGYPFVAAFFVASLVLGWIFKPLFWIGMIFTLWCAYFFRDPERVTPQDDDLVISPADGKVSAIQMVTPPAELDLGSEPMLRISVFMNVFNCHVNRAPMRGRIVSINYRSGSFVNAELDKASEDNERNGLVIETRHGQIGVVQIAGLVARRILCWANTNEPLDAGERFGLIRFGSRLDVFLPAGAAPRVSLGQTAIAGETVIAEFASAKGPVISRHS
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
Q2KAC2
Q8Z8T2
HEMH_SALTI
Protoheme ferro-lyase
Salmonella
MRQTKTGILLANLGTPDAPTPEAVKRYLKQFLSDRRVVDTPRLLWWPLLRGVILPLRSPRVAKLYQSIWMDGGSPLMVYSREQQQALAARLPDTPVALGMSYGSPSLESAVDELLASDVDHIVVLPLYPQYSCSTVGAVWDELGRILARKRRIPGISFIRDYADDGAYIDALAKSARESFARHGEPDLLLLSYHGIPQRYADEGDDYPQRCRDTTRELVSALGLPPEKVMMTFQSRFGREPWLTPYTDETLKMLGEKGTGHIQVMCPGFAADCLETLEEIAEQNREIFLEAGGKKYAYIQALNATPEHIDMILKLTAPYR
Catalyzes the ferrous insertion into protoporphyrin IX.
Q8Z8T2
Q93DA2
METN_STRMU
Methionine import ATP-binding protein MetN
Streptococcus
MSKAIIKLDHIDITFHQKKRTIEAVKGVTVHINQGDIYGIVGYSGAGKSTLVRVINLLQTPTKGKITVDQDVIFENGEKRLSSQELRKKRHEIGMIFQHFNLMAQKTARQNVAFALRHSNLSAAQKESKVTELLELVGLTDRAENYPSQLSGGQKQRVAIARALANDPKILISDEATSALDPKTTKQILALLQDLNKKLGLTVVMITHEMQIVKDICNRVAVMQEGSLIEEGSVLDIFSNPREDLTKDFIKTATGIEEALIKIKQQEIVKNLPANAALVQLKYAGKTTDEPILNNLYKKYQVTANILYGNIEILEKTPVGEMIVILEGAATNIDQALNDLTHSDLTVTVLKRGV
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q93DA2
A6V7W8
RECR_PSEA7
Recombination protein RecR
Pseudomonas
MSFSPLIRQLIESLRILPGVGQKSAQRMALMLLERDRSGGLKLAQALTAAMEGVGHCRQCRTLSEEELCPQCADPRRDDSLLCVVEGPLDVFAVEQTGYRGRYFVLKGHLSPLDGLGPEAIGIPELDARIRDGAFSEVILATNPTVEGEATAHYIAQLLADRGLTLSRIAHGVPLGGELELVDGGTLAHALAGRRPIS
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
A6V7W8
Q2YDG0
GPC5C_BOVIN
G-protein coupled receptor family C group 5 member C
Bos
MAIHRTVLMCLGLPLFLLPGARAQEQAPPGCSPDLNPLYYNLCDRSEAWGIILEAVAGAGVVTTFVLTIILVASLPFVQDTKKRSLLGTQVFFLLGTLGLFCLVFACVVKPSFSTCASRRFLFGVLFAICFSCLVAHVLALHFLVRKNHGPRGWVIFLVALLLSLVEVIINTEWLIITLVRGAGTEGDALGNGSAGWVAVSPCAIANADFVMALIYVMLLLLCAFSGAWSALCGRFKRWRKHGVFILLTTTASIAVWVVWIVMYTYGNRQHNSPTWDDPTLAIALATNAWAFVLFYVIPEVSQVTRSSPEQSYQGDLYPTRGVGYETILKEQKGQSMFVENKAFSMDEPASAKRPVSPYSGYNGQLLTSMYQPTEMTLMHKAPSDGAYDVILPRATANSQVTGSANSTLRAEDIYAAQGRQEATLPKEGKNSQVFRNPYVWD
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways.
Q2YDG0
Q99063
PRA1_USTHO
Pheromone receptor 1
Ustilago
MLDHVTPFFALFACILVLFALGWHIRSRNVGTITLSLYLFFGNLDNFVNSVAWWSTAEDKAPGFCEVSIRLRHALYIAIPASNLVIARKLESIASTRQVRASASEHKKSIIIDLLISVGLPVLYVSLMIVNQTNRYGIIEQVGCWPFLSLSWVWVLLVAAPVLIVSFASAVYSVLAFRWFWIRRRQFQAVLASSASTLNKARYIRLLVLTAIDMLLFFPIYVGSVSDTIRGAITTSYVSWSYVHTGFSYIPQFSAEVMEMQPSFKARLILSRLVCPISAYIFFAMFGLGQEARQGYKHAVLKALVFCKLRKERQKPIQNHIVANIEVVTFQSRETSGGIDGSPHSEKFSINTPTKYEEA
Receptor for the A2 pheromone, a prenylated mating factor.
Q99063
Q53138
COBM_RHOER
Precorrin-3 methylase
Rhodococcus erythropolis group
MTVYFIGAGPGAADLITVRAQRIIAASPVCLYAGSLVPQELLAECPEGARVIDTARLSLDEIVALLIEADAAGQDVARLHSGDPSIFSAVAEQVRRLESAGVAYQVVPGVPAFTAAAASLGRELTVPGVSQSIVLTRVSTLSTAMPEGEDLRSLGRSGATMVVHLGAHRIDQIAEELIEDYGRDCPAAVVAFASRPDEIVLRGTLATIADQVKAAGVTKTAVVIVGRVLAAEGFPDSYLYSATRERTTH
Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5.
Q53138
B8E088
RSMH_DICTD
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Dictyoglomus
MEEIEIIHKPVMLKEVIHYLKLSPGKIVVDATLGLGGHSSEILRELKGEGLLIGIDRDEEVLNLARERLRKIANNFVLFNTTYDKVQEILKELKLSFIDAILFDLGFSSFHIEKSERGFSFMRPEEPLDMRYSKDTTLTAADILNSFNELELSNLFWEYGEEPLSRKLAKKIVERRKEKKFVYVKDLLEVVEEVIPKRKRHEATKVFQALRIVVNDEVNILKRALDQIPFILAPRGRIVVLTYHSIEDRVVKNFFKSHSDKIFPVNKKVIRPSVNEIRENRRARSAKLRVGERRE
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
B8E088
Q9SSM4
CHM1B_ARATH
Vacuolar protein-sorting-associated protein 46.2
Arabidopsis
MGNTDKLMNQIFDLKFTSKSLQRQSRKCEKEEKAEKLKVKKAIEKGNMDGARIYAENAIRKRSEQMNYLRLASRLDAVVARLDTQAKMTTITKSMTNIVKSLESSLATGNLQKMSETMDSFEKQFVNMEVQAEFMENAMAGSTSLSTPEGEVNSLMQQVADDYGLEVSVGLPQPAGHAIPTKTEEKVDEDDLSRRLAELKARG
Involved in ESCRT-dependent multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Mediates the MVB sorting of the auxin carriers PIN1, PIN2 and AUX1. Required for embryonic axis establishment and seedling growth . Required for autophagic degradation of plastid proteins. Promotes the efficient sequestration of cargo from plastids into autophagosomes. Mediates the efficient delivery of autophagic plastid bodies to the vacuole, but not into the cytoplasm .
Q9SSM4
Q2RSU7
RLP_RHORT
5-methylthioribulose-1-phosphate isomerase
Rhodospirillum
MTDRLRATYRVKATAASIEARAKGIAVEQSVEMPLSAIDDPAVLDGIVGVVEEITERGEDCFEVRLALSTATIGGDAGQLFNMLFGNTSLQDDTVLLDIDLPDDLLASFGGPNIGAAGLRARVGASADRALTCSALKPQGLPPDRLADLARRMALGGLDFIKDDHGMADQAYAPFASRVGAVAAAVDEVNRQTGGQTRYLPSLSGHLDQLRSQVRTGLDHGIDTFLIAPMIVGPSTFHAVVREFPGAAFFAHPTLAGPSRIAPPAHFGKLFRLLGADAVIFPNSGGRFGYSRDTCQAVAEAALGPWGGLHASLPVPAGGMSLARVPEMIATYGPDVIVLIGGNLLEARDRLTEETAAFVASVAGAASRGCGLAP
Catalyzes the conversion of 5-methylthio-D-ribulose 1-phosphate (MTRu-1P) to a 3:1 mixture of 1-methylthioxylulose 5-phosphate (MTXu-5P) and 1-methylthioribulose 5-phosphate (MTRu-5P) . Involved in the MTA-isoprenoid shunt of the methionine salvage pathway .
Q2RSU7
Q23588
UTPP_CAEEL
Pyrimidine-nucleoside phosphorylase
Caenorhabditis
MNGLVKNGNVEKPNKYFDIKDKRDFLYHFGFGVDTLDIPAVFGDTKFVCTGGSPGRFKLYAEWFAKEANIPCSENLSRSDRFVIYKTGPVCWINHGMGTPSLSIMLVESFKLMHHAGVKNPTFIRLGTSGGVGVPPGTVVVSTEAMNAELGDTYVQIIAGKRIERPTQLDAALREALCEVGKEKSIPVETGKTMCADDFYEGQMRLDGYFCDYEEEDKYAFLRKLNALGVRNIEMESTCFASFTCRAGFQSAIVCVTLLNRMDGDQVQIAKEQYIEYEERPFRLVTAYIRKQTGI
Catalyzes the reversible phosphorylytic cleavage of uridine and thymidine to uracil and ribose-phosphate or thymine and deoxyribose-1-phosphate . The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (Probable). Required for normal lifespan .
Q23588
Q2YU70
DNLJ_STAAB
Polydeoxyribonucleotide synthase [NAD(+)]
Staphylococcus
MADLSSRVNELHDLLNQYSYEYYVEDNPSVPDSEYDKLLHELIKIEEEHPEYKTVDSPTVRVGGEAQASFNKVNHDTPMLSLGNAFNEDDLRKFDQRIREQIGNVEYMCELKIDGLAVSLKYVDGYFVQGLTRGDGTTGEDITENLKTIHAIPLKMKEPLNVEVRGEAYMPRRSFLRLNEEKEKNDEQLFANPRNAAAGSLRQLDSKLTAKRKLSVFIYSVNDFTDFNARSQSEALDELDKLGFTTNKNRARVNNIDGVLEYIEKWTSQRESLPYDIDGIVIKVNDLDQQDEMGFTQKSPRWAIAYKFPAEEVVTKLLDIELSIGRTGVVTPTAILEPVKVAGTTVSRASLHNEDLIHDRDIRIGDSVVVKKAGDIIPEVVRSIPERRPEGAVTYHMPTHCPSCGHELVRIEGEVALRCINPKCQAQLVEGLIHFVSRQAMNIDGLGTKIIQQLYQSELIKDVADIFYLTEEDLLPLDRMGQKKVDNLLAAIQQAKDNSLENLLFGLGIRHLGVKASQVLAEKYETIDRLLTVTEAELVEIHDIGDKVAQSVVTYLENEDIRALIQKLKDKHVNMIYKGIKTSDIEGHPEFSGKTIVLTGKLHQMTRNEASKWLASQGAKVTSSVTKNTDVVIAGEDAGSKLTKAQSLGIEIWTEQQFVDKQNELNS
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Q2YU70
C0SVZ6
CURS1_CURLO
Curcumin synthase 1
Curcuma
MANLHALRREQRAQGPATIMAIGTATPPNLYEQSTFPDFYFRVTNSDDKQELKKKFRRMCEKTMVKKRYLHLTEEILKERPKLCSYKEASFDDRQDIVVEEIPRLAKEAAEKAIKEWGRPKSEITHLVFCSISGIDMPGADYRLATLLGLPLTVNRLMIYSQACHMGAAMLRIAKDLAENNRGARVLVVACEITVLSFRGPNEGDFEALAGQAGFGDGAGAVVVGADPLEGIEKPIYEIAAAMQETVAESQGAVGGHLRAFGWTFYFLNQLPAIIADNLGRSLERALAPLGVREWNDVFWVAHPGNWAIIDAIEAKLQLSPDKLSTARHVFTEYGNMQSATVYFVMDELRKRSAVEGRSTTGDGLQWGVLLGFGPGLSIETVVLRSMPL
Catalyzes the synthesis of curcumin by condensing feruloyl-CoA with a diketide-CoA in the curcuminoid biosynthesis.
C0SVZ6
B3H2N1
GTF_ACTP7
Polymerizing glucosyltransferase
Actinobacillus
MENNIDLNVYFCFVNRPCTGGDFVNLDHVRTLRKLGINASILLAGNQSEEIVNSFGSLPVVILNEEIEFSSQDIFIVPEVMQVLYDLASKMTVFPRMIMHNQNPFYTGYGFLSAQHINEHRLERIIVPSSYTKYKLQEIGVTKPIDIIHPYIPDYFKPAEKQREVIQIAFSRRKRSAEFDIFKFYFLSLYSHKHSVNFVNIQGLTREEVAKVMSEAAIFISFAERESLGLMTLEAMASGCHVIGFSGYTDIYNNEVIDDSVGDWIGEGEYTLFAQKVCQAIDDFVNGKMNPKIENGLRLIEQRFRIRHFEQEVKRVYGNIFDYDLENSRS
Catalyzes the transfer of a glucose moiety from UDP-glucose to another glucose that is N-linked to an asparagine within a peptide or protein. Can act in a repetitive manner, and this way it elongates the N-linked glucose by a glycan chain consisting of several alpha-1->6 linked glucose residues. Is able to add up to six glucose units in vitro. Cannot use UDP-Gal, UDP-GlcNAc or UDP-GalNAc as a substrate donor.
B3H2N1
A8ZU48
CH60_DESOH
Chaperonin-60
Desulfosudis
MAGKEIKYSTKAREAMLAGVRTLADAVAVTLGPRGRNVVIEKSWGSPTVTKDGVTVAKEIELEDKFENMGAQMVKEVASKTSDTAGDGTTTATVLARAIYEEGQKLVAAGNNPMAIKRGIDKACEVAVKELAGMSKPTKNQREIAQVGTISANSDETIGNIIAEAMEKVGKEGVITVEEAKSMDTTLDVVEGMQFDRGYLSPYFVTDAEKMVVSLENAYILINEKKLSNMKELLPILEQTAKAGRPLLIIAEDIEGEALATLVVNKLRGTLNVAAVKAPGFGDRRKAMLEDIATLTGGQVVSEDVGINLEGITLGDLGHAKRITIDKDNTTIVDGAGKKADIEGRVKQIRAQIEDTTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALNATRAAVEEGVLPGGGVALVRCLDALSKIKIKSEEKLGVKVVMRAIEEPLRRIANNAGVEGSVVIEKVKNETGSFGYNAATGDYGDLIAAGVIDPTKVVRFALQNACSVASVMLTTEAMIAEKPSKEEPAAMPGGGMGGMGGMGGMGGMM
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
A8ZU48
A1SQV9
RNPA_NOCSJ
Protein C5
Nocardioides
MLSAAHRLRDGATFREAIRRGRRAGRQTLVVHLLVGEPVASQPARVGFVVSRAVGNAVIRNQVKRRLRHLAREHVSSLPGSAVLVVRALPPAANASAAELARDLERCLLRVGAEVTG
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
A1SQV9
Q39D07
QUEF_BURL3
PreQ(0) reductase
Burkholderia cepacia complex
MNPEHSPLGKATVYAAQYDASLLFPIPRAGAREQLGITSALPFFGTDIWNAYELSWLNARGKPQIAVATFYVPAESPNIVESKSFKLYLGSFAQTTFDSIDAVRDTLKRDVSAACGATVSVQLVSPHDFGKLEMEELDGLSLDRLDLDTDVYEPDPSLLKAAEDEAPVEETLVSDLLRSNCPVTGQPDWGSVQIHYVGPQIDHAGLLRYIISFRNHTGFHEQCVERIFLDILHACKPVKLAVYARYTRRGGLDINPFRTNYNQPMPDNARNARQ
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Q39D07
A1CYJ1
NOP16_NEOFI
Nucleolar protein 16
Aspergillus subgen. Fumigati
MGRVLQKKKNRSSTPKQKPKRTGQLKSGKKKINVLGNAIIAQNWDRKLTLTQNYRRLGLVHKLNAPTGGSEKRPTKDGRIEELPEDPLHIRGSAKASAKQAAMGETRVERDPETGKIIRVIRDEEEIEIGGRKVKPSNPLNDPLNELSEDEAAQQPASQRANAKSAIVQQLERQADQEGQAVKAKKPRHQSKREEEWIMRLIERHGENYSAMARDRKLNPMQQSEGDLKRRIRKWKANHSS
Involved in the biogenesis of the 60S ribosomal subunit.
A1CYJ1
Q47C26
RLMF_DECAR
rRNA adenine N-6-methyltransferase
Dechloromonas
MHPRNKNAEGYDFAALAATSAALAKHIKTTQAGTASIDFANPAAVKMLNRAILMHHYGVKGWDIPAGYLCPPIPGRADYIHSVADLLATCNKKNIPSGPGVRVLDIGVGANMVYPLIGHAEYGWSFLGVDIDEAALANAQSIIGKNPELASDIELRHQPVWDNIFTGLLRSGEVFDLSICNPPFHNSPDDVHAVSQRKWNNLNKPGAKRGAAEPRLNFGGGGSELWCNGGERAFVKRMIEQSCNIPKRVMWFTSLLSQGDNLPHIEAALKKAKVVESRIIPMAQGQKQSRLVAWTFCGNGEREKWRRERWTAAPSYAVPAFAEQTAPLTAEATPPAADPV
Specifically methylates the adenine in position 1618 of 23S rRNA.
Q47C26
P39040
TYTR_CRIFA
N(1),N(8)-bis(glutathionyl)spermidine reductase
Crithidia
MSRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFHQGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATGSWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQLRANGINVRTHENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLDKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRATDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAYFYQKGKRVEKIDSNL
Trypanothione is the parasite analog of glutathione; this enzyme is the equivalent of glutathione reductase.
P39040
B7XHR6
KIN1_ENTBH
Probable serine/threonine-protein kinase KIN1 homolog
Enterocytozoon
MQSTSKYNCDSDYIAGRNYNTKRTNGREELSTGLTNEETGVVNISDENNIFFKKNIDYVKGSRIGKYKLIKTLGKGSCAKVVQAEDCETGEYVAIKIIERTPKQLSDIRIYREALICSLFNHPHIIKLLDFFHTTEYFFLIFEYVDGQQLYDIILNKGYLDEDEARKYFRQIISAVDYSHRNSVVHRDLKIENILIDRNDNIKLIDFGLSNFYDADDLLGTFCGSLYFAAPELLLGTRYTGPEIDVWSLGVILYVMLVGKVPFDDENIHALQNKIKSCKFKFEKTISPEAQDLITNMILSSDARINLENVKKSKWTNLGYKNLTNNFMTLRKPIIEINKNILRALQAAMFFQFTDMERVLMQYLQICKGDKHSLEQTYWCKKPVVILYYLTMEKFNELNYKSIPIDIDTGMNTKSLIDITIEKQPIIIYNFVRFTNAKKNNNPYNLFFSRSVFEPEMEFLNMTKDVSLDSCNISEDENKKHNFPKIKQSIIKGLFKGIKIKNGDKDYVKNAIIKILLDLDITYEANEKSYFCSYSHSGVECHFKIDLYFNILLLEHYVVLNCLNRKKDNFKLVTELIKEKLEEIGDTSNYPENAI
Serine/threonine protein kinase involved in regulation of exocytosis.
B7XHR6
Q7Y1W1
TIC56_ARATH
Translocon at the inner envelope membrane of chloroplasts 56
Arabidopsis
MSSMNFNPFQNWFEKPPNPVPSINFVSLADSFFPKSQSPNFASIGLPKFSKKSPKPETAGTDEPGPYKQIAEQFLWECENIPDYRHTPEVDKLLNEDPVFEKKENPSTEEIEAEQKWWESFRASPVVQFMTRAEEIADDMNKMELEDNDTPYRKEDKDYWRAIPHVPGFDGRPMPRKAIKSKEESDDKFWDFMKQFLFGLWGFRQRPYPPGRPIDVAQAIGYKRLEKRYYDFIMKTGGWWYKDRLGRSRGPCEIITLKTAYGAGIIDRDTFIWGEDMDEWAPIHMVYGLEPAIATWEVRLGAAATAFLHKLQKGIPPWVPLKGREPKTYKQLQKEAIESKKRDMAVLEANGGVWPGVRTPSHALFLWASGSELTTVLESDHMPNKFIPKQLRLELAKVIPGLRPWEVISIEQAMDQISYGGEWYREPLGTYTTGPPYIREWNRSVMRLFRIFYNLSVRVGQKLERTVPGFDTIMDKVQKDYDKRIARRMKRREEELREEDLKHYSGRTDEDEEEEEEEDDDSNSKKD
Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
Q7Y1W1
B2BS84
VKT_AUSLA
Putative Kunitz-type serine protease inhibitor
Austrelaps
MTREKSLALLITLAAALAAAESPPGRCHSPKTVGPCRASFHRWRYNATSQMCQEFIFGGCKGNANNFVSKQDCFQTCIRGGAAEATVVPSGPATEVATPRAGHLPEAYENRPGFREFCAAPRVVGPCRASFLRWYFDLESRMCKMFIYGGCRGNKNNYLFEEHCWSQCTGDGEITEEPGDAGAQPPLPSEPFSFSTRAVVLAVLPAILVTILLGSMGVFFVKICRKNPELSVGTVWSTLDDKEYLMSNAYTL
Serine protease inhibitor.
B2BS84
Q6A7K8
DXR_CUTAK
2-C-methyl-D-erythritol 4-phosphate synthase
Cutibacterium
MKKVIILGSTGSIGTQTLEVISSRRDQFEVAGISAGGSDVGSLAQQIIDFSIPVVAVAREDAAEELQRALAVQAGSRGRIVPNPRILTGPDASTELAAMPADVVCNAITGAAGLRPTLATLAAGTTLALANKESLVIGGRLVTQAAASGQIVPVDSEHSAFAQCLRGGGRNEVRRLVLTASGGPFRGRDRASLADVSAAEAMKHPTWNMGRVITINSSTLVNKGLELLEAALLYDVDLDDITVVVHPQSIVHSMVEFWDGATIAQASPPDMRLPIALGLSWPDRLPDAAAGCDWSTATQWTFEPLDNDTFGAVELARRAGHAAGTAPAVFNAANESCVDAFCAGSIGFLDITDTIAAVLDEHLSGDENDTLGARHVGDEALTLDAVLAADAWGRRRAAEVCARGIRR
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Q6A7K8
A1U3L1
PYRC_MARN8
Dihydroorotase
Marinobacter
MTRQITITRPDDWHLHVRDGDILNDVVPATAACFGRAIIMPNLVPPVTDASAAMAYRDRILAAARGTDFQPLMTLYLTESTTAETIREAKAAGVVAAKLYPAGATTNSASGVTDIRNIYPVLEAMADCGMLLLVHGEVTDSDIDIFDREKVFLERVLAPTLTAFPSLRVVLEHITTAESAEFVRNHQGNNLGATLTPQHLMYNRNHMLVGGIRPHLYCLPILKRNKHQEALREAVASGDPRFFLGTDSAPHAKDKKEAACGCAGCYSAYGAIGLYADIFEELGILDKLEAFASFNGADFYGLPRNTDTVTLVREPWTMPENLPLAGGGIVPLKAGETVNWRLA
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
A1U3L1
B0XYC4
PGXC_ASPFC
Poly(1,4-alpha-D-galacturonide)galacturonohydrolase C
Aspergillus subgen. Fumigati
MLITNPALLGILASLVPLALGAPNQPIQARSRKCVIPSSYASSHGTADDSPAVASAFAQCAENSVIVFQEGVDYNIFHPIKATNLSNVEIRVLGNLHLPQDITAVQNIVKSGQSTWFTFQGPRVDWTGADDIKNGWINSYGQAWWDANPANSSSFPNRPHLMSYKTSQASIKNFRSRKPIAWNVKLQGDDITVSHAIVDATSTGGFPFNTDGFDVEGTNISITDSVMFNGDDAIAVNTPSHNIVFARNTIGYQSHGMSIGSLGKDPTDFANITNLRFEDVTVIDALYAARFKSWSGGRGLVKNVVWKNIRTFNVTFPIFVTQSYSDQSASRPGTIDPFSSVMMEDFTWSDFSGTINTYHPGDGSCVTDPCWYNVGLPNLKHTEAIVLECNTESSCKNFRTEGIRLHPQSKDSPSVICMKATAELNPKLGFECKNGTFVPH
Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.
B0XYC4
B1XS66
PTH_POLNS
Peptidyl-tRNA hydrolase
Polynucleobacter
MTKLIVGLGNPGEEHEEDRHNAGFWFVDALAKQLGVRFESEKRFHGKVAKAKWEGEDLFLLKPSTYMNLSGQSVGALCRFHKIMPADILVVQDELDIKPGSARLKLGGGTGGHNGLKDIQAHLSTPNYWRLRLGIGHPRDIAGDGRPMDVADYVLRRPQLTEQKLINTSIENGLNILSLFLKGDTQTAMMELHSKG
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
B1XS66
A4WD96
NDK_ENT38
Nucleoside-2-P kinase
Enterobacter
MTIERTFSIIKPNAVAKNVIGSIFARFESAGFKIVGTKMLHLTVEQARGFYAEHDGKPFFDGLVEFMTSGPIVVSVLESENAVQRHRDLLGATNPANALAGTLRADYADSFTENGTHGSDSVESAAREIAYFFAEGEVCPRTR
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
A4WD96