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AlphaFoldDB
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Q2NU39
ACP_SODGM
Acyl carrier protein
Sodalis
MSTIEESVKAIIAEQLGVKKEEVVNNASFVDDLGADSLDTVELVMALEEEFDTEIPDEEAEKITTVQAAIDFIQASQQ
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Q2NU39
Q6GLG7
UBA5_XENTR
UFM1-activating enzyme
Silurana
MEKLIEELRSRVSELEEELHRVRNGEQVHEGHRAKINTMSAEVVDSNPYSRLMALKRMGIVEDYEKIRTFTVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVEMANMNRLFFQPHQAGLSKVEAAEHTLRNINPDVQFEVHNYNITTLDNFQHFMDRISKGGLKEGTPVDLVLSCVDNFEARMAINTACNELVQIWMESGVSENAVSGHIQLIKPGETACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGMLVQNVLKYLLNFGTVSFYLGYNAMQDFFPTMAMKPNPQCGDKYCRKQQEEFKLKEAARPKQEPIVVKEEEIVHEDNDWGIELVSEVSEEELKAASGPVPELPEGIKVAYTVPITEPTSGFIVEDSEQSLDELMAQMKNL
E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates ufm1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ufm1-E1 thioester and free AMP. Activates ufm1 via a trans-binding mechanism, in which ufm1 interacts with distinct sites in both subunits of the uba5 homodimer. Trans-binding also promotes stabilization of the uba5 homodimer, and enhances ATP-binding. Transfer of ufm1 from uba5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.
Q6GLG7
Q22782
RAB6B_CAEEL
Ras-related protein rab-6.2
Caenorhabditis
MSDFGNPLKKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNSNSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSDKRQVTTDEGERKAKELNVMFIETSAKAGYNVKQLFRRIAGALPGIIKDDPVEPPNVVTMDPIRQRQIVTDEGSCWC
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes . Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion . In its active GTP-bound form, acts redundantly with rab-6.1 (in its active GTP-bound form) to positively regulate the retrograde trafficking of cargo molecules from endosomes to the Golgi compartment . Required for the retrograde trafficking of glr-1, a subunit of AMPA-type glutamate receptors (AMPRs), out of early endosomes and into the Golgi compartment in neurons . Its role in glr-1 trafficking may partly be mediated by its interaction with lin-10 and association with components of the retromer complex such as rme-8 . Together with rab-6.2, promotes the retrograde trafficking of mig-14 from endosomes to Golgi structures in the intestine . Plays a role in the epidermis to promote cuticle integrity and impermeability of the cuticle barrier to exogenous molecules . May have a role in the glycosylation of the cuticular surface . Required for seam cell division and alae formation . Required for grinder formation, which is the feeding organ that breaks down food . In contrast to rab-6.1, may play a minor role in the exocytosis of secretory vesicles (cortical granules) during the oocyte-to-embryo transition .
Q22782
Q0AJE1
MURG_NITEC
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Nitrosomonas
MIMAGGTGGHVFPGLAVARAMQAEGWRVIWLGTRNGMEATLVPQHGFTIELINFSGLRGKKPVSYLLLPWRLAKACWQSFCILRRQRPQIVLGMGGYPALPGGIMAVLSGKPLLIHEQNRIAGLTNKILAKIASRILLAFPGTITDQAGKIQVTGNPVRTEIAQLPSPEVRYAKRAGKLNILVVGGSLGAQALNTVLPQALSMIPGNQRPFVTHQSGKVHLAALQQAYAEHGVTGNLVAFIEDMAVYYQNCDLVVCRAGALTIAELAAAGVASILVPYPYAVDDHQTANARFLSEHHAAVLWPQSELTANSLAQWLMTCTRTQLQTMAINARMLAMPEAAQSVVTVCQQLIETGP
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Q0AJE1
P51160
PDE6C_HUMAN
cGMP phosphodiesterase 6C
Homo
MGEINQVAVEKYLEENPQFAKEYFDRKLRVEVLGEIFKNSQVPVQSSMSFSELTQVEESALCLELLWTVQEEGGTPEQGVHRALQRLAHLLQADRCSMFLCRSRNGIPEVASRLLDVTPTSKFEDNLVGPDKEVVFPLDIGIVGWAAHTKKTHNVPDVKKNSHFSDFMDKQTGYVTKNLLATPIVVGKEVLAVIMAVNKVNASEFSKQDEEVFSKYLNFVSIILRLHHTSYMYNIESRRSQILMWSANKVFEELTDVERQFHKALYTVRSYLNCERYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREVNFYKIIDYILHGKEEIKVIPTPPADHWTLISGLPTYVAENGFICNMMNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEYITETLTQFLGWSLLNTDTYDKMNKLENRKDIAQEMLMNQTKATPEEIKSILKFQEKLNVDVIDDCEEKQLVAILKEDLPDPRSAELYEFRFSDFPLTEHGLIKCGIRLFFEINVVEKFKVPVEVLTRWMYTVRKGYRAVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGSSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDACEQMQTEEEAIKYVTVDPTKKEIIMAMMMTACDLSAITKPWEVQSQVALMVANEFWEQGDLERTVLQQQPIPMMDRNKRDELPKLQVGFIDFVCTFVYKEFSRFHKEITPMLSGLQNNRVEWKSLADEYDAKMKVIEEEAKKQEGGAEKAAEDSGGGDDKKSKTCLML
As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.
P51160
I1RL15
DPFGH_GIBZE
Diterpenoid pyrone biosynthesis cluster protein H
Fusarium
MSPLWVRRLCIRVVDSLYGSFLYLPLAILFLKRSVTGFGTGEWDESQIPKLDGKVAVVTGGNAGIGYYTVKHLASRGAKVYLGARSESRAKAAIKRLLEENPLIPQENVVWLRLDLANQSQVVDAAVELQSKEQRLDILVNNAGIDPYDYIRTADGFEMTMAVKYTNPAAAAQEESDVRVITVSSSGEAYSSPTNQFTSPKDLDDPCASPGWENSCLGQAMRYGTTKLANVLFASELQRRMDEEDANIISLSLNPGTVRTDGAANVMPFMVRPLVRFLFTAPERGADTSLFAATAEEIKENSERWKGRYLDGPGRIKVPSLRARDAVAGRNLWNITEAAVRGTGALDRL
Short chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones . The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B . Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B . The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation . Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E .
I1RL15
C1KZ12
RL13_LISMC
50S ribosomal protein L13
Listeria
MRTTYMAKPGEVERKWYVIDATGVSLGRLSSEVASILRGKNKPQFTPHIDTGDFVIIINAGKIGLTGKKATDKIYYRHSQYPGGLKSRTAGEMRTNNPEKLLELSIKGMLPKNSLGRQLFKKLHVYGGSEHEHAAQQPEVYELRG
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
C1KZ12
A7MK11
MTNC_CROS8
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Cronobacter
MIRAIVTDIEGTTTDIRFVHNVLFPYARERLERFIRSGEQREPVNLLLNELRGEIHAPAASVDQLIETLFKFMDEDRKSPALKSIQGYIWREGYVNGDFTGHLYPDVVPALRRWSAQDIDIYIYSSGSVPAQKLLFSHSDEGDVTELLSGFFDTHVGAKRQVSSYRNISMKTGVPVHQMLFLSDIREELDAAREAGWKTVQLIRGEPDTQSTHRQVSSFDDIHPEQIPT
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
A7MK11
Q97EH2
RS12_CLOAB
30S ribosomal protein S12
Clostridium
MPTISQLVRKGRKTLAAKSTAPALKECPQKRGVCTVVKTTTPKKPNSALRKIARVRLTNGYEVTAYIPGVGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGTLDAAGVADRKQARSKYGAKKPKQK
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
Q97EH2
Q0SIG6
TATA_RHOJR
Sec-independent protein translocase protein TatA
Rhodococcus
MGAMSPWHWAIVALVVIILFGSKKLPDAARGLGRSLRIFKSEVKEMQNDNSTPAPTAQQSAPAELPVADTTTAPVTPPAPVQPQHTEPKSA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q0SIG6
P0C245
TX622_PSACA
Vanillotoxin-2
Psalmopoeus
GACRWFLGGCKSTSDCCEHLSCKMGLDYCAWDGTF
Selectively activates the mammalian capsaicin receptor TRPV1, a non-selective cation channel expressed by sensory neurons of the pain pathway. Is more potent than VaTx1, but less potent than VaTx3. Interacts with distinct regions of the channel than capsaicin, since it only acts on the extracellular face of the channel, and capsaicin binds to the cytosolic side. Also activates avian TRPV1, which is insensitive to capsaicin. Produce weak inhibition on potassium channels Kv2.1/KCNB1.
P0C245
Q8YHM6
RS8_BRUME
30S ribosomal protein S8
Brucella
MSVSDPLGDMLTRIRNAVGRKKTKVSTPASKLRARVLDVLQAEGYIRGYTQSEFENGKAEIEIELKYYEGVPVIREITRVSKPGRRVYVSVKSIPQVVNGLGISILSTPKGVMADHEAREQNVGGELLCRIF
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Q8YHM6
P31381
FUN26_YEAST
Nucleoside transporter FUN26
Saccharomyces
MSTSADTDTIKKPILAVPEPALADTHSEEISRSGEEHESENNEHSDEEGDNYSEREQSVSTEPLDTLPLRKKLKNLSYITFFAIGIGLLWPWNCILSASQYFKHDIFKDTSIWAKIFTSSMMSFSTISSMLFNIYLAKRQYKYSRRVINGLVWEIIVFTVMCFFTILHFLLPKWFNFMFIMMLVVISSMGTAMTQNGIMAIANVFGSEYSQGVMVGQAVAGVLPSLVLFALAFIENSSVSTTGGILLYFFTTTLVVTICVVMFSVSKISRKVNENWNVEDGHITDVLLGSLRSNEEEIRIVGRIDQMEDEDHRRTNGTRDDNDEGEELQLKVPFEVLFAKLKYLVLSIFTTFVVTLVFPVFASATYVTGLPLSNAQYIPLIFTLWNLGDLYGRVIADWPMFRDQKFTPRKTFIYSLLRVAAIPLFLMFTAITSSSSGDEEHNGSVIVDLCYMLLQFLFGVTNGHVISMSFMKVPEQLDNDDEKEAAGGFTNIFVSTGLALGSIISYVFVFIIDFIIR
Has broad nucleoside selectivity (uridine, adenosine and cytidine) and most likely functions to transport nucleosides across intracellular membranes.
P31381
Q9H8W5
TRI45_HUMAN
RING finger protein 99
Homo
MSENRKPLLGFVSKLTSGTALGNSGKTHCPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQGLVCDLCNDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSRIGKPILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTINTKEVDPAKCVLQGEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTVMVRRKHRPHSGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGHPHWSCCGKFNEKSECTWTGGQSAPRSLLRTVAL
May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.
Q9H8W5
Q4UR40
PDXA_XANC8
4-(phosphohydroxy)-L-threonine dehydrogenase
Xanthomonas
MVPSLALVPGEPAGIGPELCIRLAQQPRSDAHLIAYADPDTLHSAAKALCLSVRLLDPDQHARLPGDLPLHPVRQAAPTRFGTPDPANAAAVIAGLLGAAGDCLSGKLQGIVTGPVHKAVINAGGIAYTGTTELLAAQAGCPVVMMLANSIVRVALVTTHLPLRAVPEAITAEALARCLRITATAMQRDFGLEHPRIAVLGLNPHAGEDGLLGREELDVIIPVLDQLRSEGMQLIGPLPADTAFLPQKLTDFDAVVAMYHDQGLPVLKYSGFEQAVNITLGLPYPRVAVDHGTALELAGRGVADPSSLLAATALCARLAARS
Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).
Q4UR40
A9KL10
MUTS_LACP7
DNA mismatch repair protein MutS
Lachnospiraceae
MAQLTPMMQQYVETKEQYKDCILFYRLGDFYEMFFEDALVASKELEITLTGKNCGQEERAPMCGIPYHAAEGYISKLIGKGYKVAICEQVEDPKLAKGIVKREVIRIVTPGTNLNTQTLDETRNNYLMGIIFTDEHCGISTVDITTGDYYVTEVENNRKILDEIYKYTPSEIVCNPEFFHCGLDVEDLKNRYQIAVSTFEDWYYDSEQSVKTLKEHFKVGSLDGLGLKDYSVGVNAAGAILKYLYNTQKNSLSHLTHITPYVTSRYMVIDSSSRRNLELTETLREKQKRGSLLWVLDKTKTAMGARMLRSFVEQPLITMDEISARYDAISELNDNVITREEIREYLNYIYDLERLMGKISYKSANPRDLIAFASSLSMLPHIKYLLSTCESALLKQIHEEMDALDDLQNLIDRSIAEEPPIGIKEGGIIKEGFHTEVDTLRKAKTEGKVWLAELEAKEKEQTGIKNLKVKYNRVFGYYLEVTNSYANLVPENWIRKQTLSNAERYTTPELKELEDKILNAEDRLFSLEYDLFAEIRDQIAEEVKRIQKTAKAVANIDAFASLAYVAERNQFIRPELNTNGTIDIKEGRHPVVEQMIPNDMFVSNDTYLDNAEKRISIITGPNMAGKSTYMRQTALIVLMAQVGSFVPASYANIGIVDRIFTRVGASDDLASGQSTFMVEMTEVANILRNATKNSLLILDEIGRGTSTFDGLSIAWAVIEHISNTSMLGAKTLFATHYHELTELEGKISGVNNYCIAVKEQGEDIVFLRKIIGGGADKSYGIQVAKLAGVPNSVLVRAREIVDQLSENDIAEKARHIVSAAEISNLTPETEGEVNTNKMYTTKVNATEVITTEVNTAKMNTTEMVSNQESVEQPRNFGQMSFFITEDTKQKKASSEFSEKLVQEINQFDLANMTPVEALLKLDKLQKKIRSHT
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
A9KL10
A5GPE6
GATB_SYNPW
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
unclassified Synechococcus
MAAPAATDQAWEAVIGLETHVQLGTNSKIFTAASTAFGDDPNTHIDPVVCGLPGTLPVLNQKVLEYAVKAAMALNLNIAEHSKFDRKQYFYPDLPKNYQISQYDEPIAEDGWIEVEVAEKGKDTYLKTIGIERLHMEEDAGKLVHAGSDRLAGSTHSLVDYNRAGVALAEIVSKPDLRTGREAAEYASEIRRIMRYLGVSDGNMQEGSLRCDVNISVRRGPEAPFGTKVEIKNMNSFSAIQKACEYEIQRQIKAYEAGEPIVQETRLWDESKQLTKSMRSKEGASDYRYFPDPDLGPIEVSADQRDSWRAELPELPAAKRHRYADTLGLSQYDARVLTDEKPMADYFEAVVVAGADAKLAANWITGDIAAYVNSNRLSYANLPFRPEQLAEMVQLIDGGKISGKIAKEILPELLENGGSPKAIVDERGLGMISDPAAIEAIVDELLGAHPDEVEAFRGGKTKLQGFFVGQLMKKTGGKADPKLANQILSKKLKG
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
A5GPE6
Q7WFS0
MURD_BORBR
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Bordetella
MNTTETSRAAAPLVLILGLGETGVAAARWCARQGSPLRVADTRAQPGGLAALQAALADATVEYRLGCGEQFPPDLLDGVAQIVLSPGLVPHESPTRELLEQARERNVEVVGEIELFARALAGLAESREYRPRVLAITGTNGKTTVTALTRQLIEAGGMSARAAGNISPAALAALIDALDQDDLPQVWVLELSSFQLETTRTLAPDAAVVLNVTQDHLDWHGDMQAYAQAKARILKPARLAIVNRDDPLTVAMVESLQALNVRSFGRDVPALVGDMGLELGQGVAWLTACESNDFDEPAPAPRRKKDAPPPTRAGGRMSRLMPVDALRIRGVHNALNALAAMQLARSLDLGWGPMLRTLRDYAGEPHRAELVRSIGDVDYINDSKGTNVGATVAALEGLGQQVVLIAGGQGKGQDFSPLVPVVRRHARAVVLIGVDGAAIGKVLEPTGVPCVAAADMREAVRRAAELAQPGDAVLLSPACASFDMFRNYPHRGEVFAAEVQELALDRGEVA
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Q7WFS0
Q2VLG6
C163A_CANLF
Soluble CD163
Canis
MSKLRMVPHGNSGSADFRRCFALLCPSAVAVVSILSTCLMTNSLGRADKEMRLTDGEDNCSGRVEVKVQEEWGTVCNNGWGMDEVSVICRQLGCPTAIKAAGWANSRAGSGRIWMDHVSCRGNESALWDCKHDGWGKHNCSHQQDAGVTCSDGSSLEMRLMNGGNQCSGRIEVKFQGQWGTVCDDNFNIDHASVVCKQLECGSAVSFSGSANFGEGSGPIWFDDLVCSGNESALWNCKHEGWGKHNCDHAEDVGVICLDGADLSLRLVDGVTECSGRLEVKFQGEWGTVCDDGWDSNDAAVVCKQLGCPTAVTAIGRVNASEGSGHIWLDNLSCQGDESALWQCRHHEWGKHYCNHNEDAGVTCSDGSDLELRLVGGGSRCAGTVEVEIQKLLGKVCDRGWGLKEADVVCKQLGCGSALKTSYQRYSKVKATNTWLFLSRCSGNETSLWDCKNWQWGGLSCDHYEEAKVTCSAHREPRLVGGDIPCSGRVEVKHGDTWGTVCDSDFSLEAASVLCRELQCGTVISILGGAHFGEGNGQIWAEEFQCEGQESHLSLCSVASRPDGTCSHSRDVGVVCSRYTEIRLVNGQSPCEGRVELKILGNWGSLCNSHWDIEDAHVFCQQLKCGVALSIPGGAHFGKGSGQIWRHMFHCTGTEQHMGDCPVTALGATLCSAGQVASVICSGNQSQTLSPCNSTSLDPTRSTTSEESAVACIASGQLRLVNGGGRCAGRIEVYHEGSWGTICDDSWDLSDAHVVCRQLGCGVAINATGSAHFGEGTGPIWLDEVNCNGKESHIWQCRSHGWGQHNCRHKEDAGVICSEFMSLRLIDETSRDICAGRLEVFYNGAWGSVGKSNMSATTVEVVCRQLGCADKGSINPASSDKPMSRHMWVDNVQCPKGPDTLWQCPSSPWKQRVASSSEETWITCANKIRLQEGTSNCSGRVELWHGGSWGTVCDDSWDLEDAQVVCRQLGCGPALEALKEAAFGQGTGPIWLNDVKCKGNESSLWDCPARPWGHSDCGHKEDAAVRCSEIAMAQRSSNPRGHSSLVALGIFGVILLAFLIALLLWTQRRRQQQRLTVSLRGENSVHQIQYREMNSSLKADDLDVLTSSEYPNESDDFNDAGLISVSKSLPISG
After shedding, the soluble form (sCD163) may play an anti-inflammatory role.
Q2VLG6
P51369
CCSA_PORPU
Cytochrome c biogenesis protein CcsA
Porphyra
MNLEMMQNSCVNFAFGGLLTAMLVYWSSLAFPRISGLNKLAALITLLVNIALALTLSSRWFANGYFPLSNLYESLLFLAWGLTFVHLFIESKTKSRLIGAVSIPVAMFVTAFASLALPIEMQKASPLVPALKSNWLMMHVSIMMISYSILILGSLLSILFLIITRGQDINLKGSSVGTGSYTVKSLDSNPSFAFSNPSGIVQEQSNMLINSTRMNLLESIDNLSYRIIGLGFPLLTIGIVAGAVWANEAWGSYWSWDPKETWALITWLIFAAYLHCRITKSWQGKRPAILASVGFLVVWICYLGVNFLGKGLHSYGWLA
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
P51369
Q6BL68
YAE1_DEBHA
Protein YAE1
Debaryomyces
MSSKCNGDCSCTSKVDSGVADKTEMTKNESNDIDDIWGDDDIEELDNSTADIKRMHSKQGYLDGITSAKESSLQDGFDDSFPKGAELGIIVGNILGSLISYDDQELFDQAKSELNISQVLHKRYFDEDLELRSTNDHEVIAKWQNVVQNLENK
The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation.
Q6BL68
C0QUC0
MTNA_PERMH
S-methyl-5-thioribose-1-phosphate isomerase
Persephonella
MRKIKDIRPIQLKDHKLYVINQLKLPKEKEWLELSTYQQVAEAIEKMIIRGAPLIGIVGAYGFAIGVKQILDEGRSLDDVRDVFDRLKNTRPTAVNLFWALERVWKKFERWTEEGRSGEELVNLLFKEAERIDLEDYHANKAIGGYGQVLLPERCNVLTHCNTGALATSGWGTALGVIRSAFENGKDITVYVDETRPYLQGSRLTAWELVEEGIPHYLITDNSAGFLMSKGIIDAIIVGADRITANGDVANKIGTYTLAVLAEAHGIPFYVAAPTSTFDLDTDSGKDIPIEERSQLEVKKCGGCDIAPEETEALNYSFDVTPASKITAIITEKGIISHVDKEHITKFLRYRGV
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
C0QUC0
Q1Q8P0
RS7_PSYCK
30S ribosomal protein S7
Psychrobacter
MPRRRVVATREILPDPKFGSQTVAKFINHVMSHGKKSTAERIVYGALETVSQKRNIEDPVSFFEEVLENVRPMVEVKARRVGGATYQVPMEVRPSRRTALAMRWLAEAAAKRSEKSMALRLAGELNDAADGKGNAMKKRDEVHRMADANKAFSHYRF
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
Q1Q8P0
Q6CSN0
PUL3_KLULA
Pulcherrimin biosynthesis cluster protein 3
Kluyveromyces
MKLTDSQKHLYSQYLAVTLIAVQFSFDTCVYLSSVVQYVKECGSDDPENYLFILQAVSAAVQVFFSFIIGDIASYVGSIKWVIIFLYFLSFVGNFLYSCAGAVSLNTLLGGRIICGAASSSGAVVYSYITAISKDRTTIFKLFSIYRTSAGICMALAQLVAILFALCDFTVRGYRITSYNAPTFASSFIILLICVLLMFVLENPPVKSARNPKNYLDAWKKFFSAGSNRLIASLILLWNMFLSTFFMCEVLYFMPIFLTLNVGWKTEYEGVAFMVSAVLGVAGSFFAPDLVKLFAKLNTPSTQDETDTSDNDKIEKEESEQKSDINTLHRNQVSLTIFALFVALIGQAFMIGASEALSNDKLPKTNSGIFFTAGLSITMLGYNFMGSSVPALFSMYIDPQVKVQLMPFIGAIAGVGKLVAPIVLAALYKTPLGLPIGVGFGMILVGISIPSLVYLRRNKM
MFS-type transporer required for the uptake of iron via the uptake of the siderophore pulcherrimin-iron complex.
Q6CSN0
Q6SSJ6
MOBA_COMTE
M-hydroxybenzoate hydroxylase
Comamonas
MQFHLNGFRPGNPLIAPASPLAPAHTEAVPSQVDVLIVGCGPAGLTLAAQLAAFPDIRTCIVEQKEGPMELGQADGIACRTMEMFEAFEFADSILKEACWINDVTFWKPDPAQPGRIARHGRVQDTEDGLSEFPHVILNQARVHDHYLERMRNSPSRLEPHYARRVLDVKIDHGAADYPVTVTLERCDAAHAGQIETVQARYVVGCDGARSNVRRAIGRQLVGDSANQAWGVMDVLAVTDFPDVRYKVAIQSEQGNVLIIPREGGHLVRFYVEMDKLDADERVASRNITVEQLIATAQRVLHPYKLDVKNVPWWSVYEIGQRICAKYDDVADAVATPDSPLPRVFIAGDACHTHSPKAGQGMNFSMQDSFNLGWKLAAVLRKQCAPELLHTYSSERQVVAQQLIDFDREWAKMFSDPAKEGGQGGVDPKEFQKYFEQHGRFTAGVGTHYAPSLLTGQASHQALASGFTVGMRFHSAPVVRVSDAKPLQLGHCGKADGRWRLYAFAGQNDLAQPESGLLALCRFLESDAASPLRRFTPSGQDIDSIFDLRAIFPQAYTEVALETLPALLLPPKGQLGMIDYEKVFSPDLKNAGQDIFELRGIDRQQGALVVVRPDQYVAQVLPLGDHAALSAYFESFMRA
Converts 3-hydroxybenzoate (m-hydroxybenzoate), and to a lesser extent p-hydroxybenzoate, to 3,4-dihydroxybenzoate (protocatechuate). Also acts on a number of analogs of 3-hydroxybenzoate substituted in the 2, 4, 5 and 6 positions.
Q6SSJ6
P0A2G4
CITA_SALTI
Citrate utilization protein A
Salmonella
MAQHTPATSRAGTFGAILRVTSGNFLEQFDFFLFGFYATYIARTFFPAESEFASLMLTFAVFGSGFLMRPVGAIVLGAYIDRIGRRKGLMVTLAIMGCGTLLIALVPGYQTIGLAAPALVLLGRLLQGFSAGVELGGVSVYLSEIATPGNKGFYTSWQSASQQVAIVVAALIGYSLNITLGHDAISEWGWRIPFFIGCMIIPLIFVLRRSLQETEAFLQRKHRPDTREIFATIAKNWRIITAGTLLVAMTTTTFYFITVYTPTYGRTVLNLSARDSLIVTMLVGVSNFIWLPIGGAISDRIGRRAVLMGITLLALITTWPVMQWLTAAPDFTRMTLVLLWFSFFFGMYNGAMVAALTEVMPVYVRTVGFSLAFSLATAIFGGLTPAISTALVKLTGDKSSPGWWLMCAALCGLAATAMLFVRLSRGYIAAENKA
Uptake of citrate across the boundary membrane with the concomitant transport of protons into the cell (symport system).
P0A2G4
A7MXJ9
TYSY_VIBC1
Thymidylate synthase
Vibrio
MKQYLDLCQRIVDQGTWVENERTGKRCLTVINADLTYDVANNQFPLVTTRKSFWKAAVAELLGYIRGYDNAEDFRKLGTKTWDANANLNEAWLNNPFRKGEDDMGRVYGVQGRSWAKPDGGHIDQLRKIVDDLTRDVDDRGEILNFYNPGEFHIGCLRPCMYSHHFSLLGDTLYLNSTQRSCDVPLGLNFNMVQVYVFLAIMAQITGKKPGQAYHKIVNAHIYEDQLAPMRDIQLKREPLKAATFHINPEIKSLEDLETWVTLDDFWVEGYEHHDPIQYPFSV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
A7MXJ9
Q98N70
RL11_RHILO
50S ribosomal protein L11
Mesorhizobium
MAKKIAGQLKLQVSAGSATPSPPIGPALGQRGINIMEFCKAFNAQTQEMEKGSPVPVVITYYQDKSFTFVMKTPPVSYFLKKAANLKSGSKEPGKVKAGTVSRDKVREIATAKMKDLNANDVEAAMRMVEGSARSMGLEVVG
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Q98N70
Q5SKZ7
NQO15_THET8
NDH-1 subunit 15
Thermus
MSASSERELYEAWVELLSWMREYAQAKGVRFEKEADFPDFIYRMERPYDLPTTIMTASLSDGLGEPFLLADVSPRHAKLKRIGLRLPRAHIHLHAHYEPGKGLVTGKIPLTKERFFALADRAREALAFA
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP. The Nqo15 subunit has probably a role in complex stabilization, and may be also involved in the storage of iron for iron-sulfur cluster regeneration in the complex.
Q5SKZ7
A4JDP6
IOLG_BURVG
Myo-inositol 2-dehydrogenase
Burkholderia cepacia complex
MTLQIGVIGCGAIGQDHIRRLTRTLSGARVVAVNDIDPQQARDAVTKYGLDAEIYGDGHDVVAAADVQALLVTSWGPTHEAFVLDAIAHGKPVFCEKPLAVTADGCMRIVEAEVAHGKRLVQVGFMRPYDEGYRALKRVIDSGEIGAPLMLHCAHRNQSVGERYTTDMAITDTLIHELDVLRWLLGEDYASAQVVYPKKTRHASAHLADPQIVLLETVSGVRIDVEIFVNCQYGYDIQCEVVGENGIAKLPDPPAVGLKHAARQSVEIMTDWKERFIASYDVELQAFIDGVRAGALTGPSAWDGYAAAVAADACVRAQRSAAVEPIAMAERPAFYRG
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
A4JDP6
B7V9S6
GCS2_PSEA8
Gamma-glutamylcysteine synthetase 2
Pseudomonas
MTHDLAASGLRFGIEEEFFLLDASDLDIVRSAPAGFVAACRDTLGEHFAEEMFECQVEVASPVFSTLAEAARFHGQARQRLAHLAMDFGLRSLCVGTHPFADWRRARSNPAAHFARLFEDQGRVARRSLVCGLHVHVEIPPSHDRMAVLQRVLPWLPLLLALSASSPFRGGRRSGLASYRRALCGEWPRMNIPPALPDEDAYRRHLALLRETGCIREDGQVWWMIRPSSHVPTLELRICDACPRLADALSLAGLFRALVGEALDADPRALPVARDACLEENYWQALRYGCAGRYLVEGRCVGAGDWLEMAWRQCRPQARRGNEWAYQHACGLLEETSAARQLRRYRRLREAGQERHPALRRLVEELLEENLQPALAG
ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
B7V9S6
A0QF49
MRAY_MYCA1
UDP-MurNAc-pentapeptide phosphotransferase
Mycobacterium avium complex (MAC)
MRQILIAVAIALTVSILLTPALIRLFTRQGFGHHTREDGPPTHHAKRGTPSMGGVAIIAGIWAGYLGTHLAGLAFDGEGISASGLLVLSLATVLGIVGFLDDLIKIRRSRNLGLNKTAKTIGQVAAAVLFGVLALGFRNANGLTPASADLSYVREIATVTLAPGLFVLFCVVVVSAWSNAVNFTDGLDGLAAGSMAMVTAAYVLITFWQYRNACVTAPGLGCYNVRDPLDLAIVAAATAGACIGFLWWNAAPAKIFMGDTGSLALGGIIAGISVTSRTEILAVVLGSLFVAEVSSVVLQILTFRTTGRRVFRMAPFHHHFELAGWAETTVIIRFWLLTAIACGLGVALFYGEWLAAIGA
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
A0QF49
Q51831
MURC_PORGI
UDP-N-acetylmuramoyl-L-alanine synthetase
Porphyromonas
MKRVYFIGIGGIGMSAIARYFHAKGFNVCGYDLTPSPITDQLIKEGIEVHFSDDLNMIPKAFFSPTDSLIVYTPAVPADHSELTYFRSNGYRVVKRAEVLGEITLMERALCVAGTHGKTTTSTLLAHLLKQSHVDCNAFLGGISNNYQSNLLLSDKSDLVVVEADEFDRSFHHLKPFMAIITSADPDHMDIYGTAENYRDSFEHFTSLIQSGGALVLKYGAPVNPRLGSDVSLFTYSSDDQQADYFASDIMIRDGRLFFTWHYPGGQLEGVELGVPVRINVENAVAAMAIAHLNGVTVEELRSGIASFKGSHRRFEKVLDTERVVLIDDYAHHPVELDAAIHSVREIYSGKHIMGIFQPHLYSRTADFYQDFARSLSMLDEVVLLDIYPARELPLPGVTSRLILDLIENPNKTLVSKNDLLDYLHGNEIPDVVLILGAGDIDRLVIPVKQYLQTLC
Cell wall formation.
Q51831
Q0SMU9
HTPG_BORAP
High temperature protein G
Borreliella
MKKQFDTEVNDLLYLIIHSLYSHKEIFLRELISNASDAIDKLKFLSLTNEKFKNIALEPKIEITFDDKSILIKDNGIGMNEQELTNHLGVIAKSGTKEFINNLKQDEKKSANLIGQFGVGFYSAFIVSEKVEVTSKKALESDAYIWSSDGKTGYEIEKAKKEDPGTEIKLYLNKEGLEYANKWKIQEIVKKYSNHINYPIYIKYNEPIMKDGKQEGIEEKEEKLNETTALWTKNKSEIKTEEYNEFYKNTTFDYENPLMYIHTKAEGNLEYTNLFYIPSKAPYDLYYPNTKPGVKLFINRIFITDSEGSLLPNYLRFIKGIIDCQDLPLNVSREILQQNKILSKIKSSSVKKILSELEKLSKKNPEKFSEFSKEFGRCIKEGVYSDFENREKLISLIRFKSSSVDGFVSFKEYKERMNEGQKSIYYITGGKENILKENPIVTAYKEKGFEILIMDDELDEAILNLIPEYEGLKLKAINKNETSNELKDENFKKIEEEFKDTLTRVKEILKDQIKEVNLSATLIKEPSAIIVDSNDPTYQMQKIMLSMGQEVKEIKPILELNPNNKIVQNLKNLEPEKLEKISILLFEEALLTSGMPSKNPRKFINIINEFLEKDLL
Molecular chaperone. Has ATPase activity.
Q0SMU9
Q1JDN4
RNPA_STRPB
Protein C5
Streptococcus
MKKTYRVKCEKDFQAIFKDGKSTANRKFVIYHLNRGQDHFRVGISVGKKIGNAVTRNAVKRKIRHVIMALGYQLKSEDFVVIARKGVESLEYQELQQNLHHVLKLAQLLEKGFESEEKH
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Q1JDN4
P56328
YCF12_CHLVU
Photosystem II reaction center protein Ycf12
Chlorella
MNLEIVFQLTALLFVVAAGPLVIVLLASRGGNL
A core subunit of photosystem II (PSII).
P56328
A2BP39
TRMB_PROMS
tRNA(m7G46)-methyltransferase
Prochlorococcus
MRQHVNPLSINFNQIERIPSLGEMFGDSKLNLHLDIGCAAGEFLFDLALVNTSWNYLGIEIREKLVKNAKLKVLESEIKNLYFLFGNANNILNDVQSELIIKNLKSISFYFPDPWFKKRHYKRRVIQPEFINILSNLLQKGTLIFIKTDVKDLFDYMDYTISNNFYFKTIDKKDFNYSESFNPNKVKTNREKYVINNQLDIFERIYIKI
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
A2BP39
A5D3G1
RUVB_PELTS
Holliday junction ATP-dependent DNA helicase RuvB
Pelotomaculum
MKDRLISAVARPEDADVDTSLRPRLLAEYIGQEKVKETISVFIQAARGRGEPLDHVLLFGPPGLGKTTLANIIANEMGVSIRTTSGPAVERPGDLAAILTSLSQGDILFIDEIHRLSRTVEEVLYPAMEDYALDIVIGKGPGARSLRLELPRFTLVGATTRAGLLTSPLRDRFGVISRLEYYRPEDLVLIVNRSARILGIEITAEGAFEIARRSRGTPRVANRLLKRVRDYAQVRANGVITCEVAVEALKFLEVDPLGLDFADRRLLLTIIQKFGGGPVGLETIATAVNEEPETVEDVYEPYLIQLGMLARTPRGRVTTPLAFRHLGLEPAREETDQVSLW
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
A5D3G1
Q44064
DRNF_AERHY
Periplasmic deoxyribonuclease
Aeromonas
MSRPSRVLGLPLLSLGLTLLVSTPLQAQEAQTFRAVKQDLVKLYQSHPSTFYCGCNIKFSGKKMAPDWESCGYLPRKQANRAARIEWEHVVPAWEFGHQLQCWQEGGRKNCGKSAEFNKMEGDMHNLFPAIGEVNGDRANYRFSDWNGKPNQYGKCQMLVDFKEQRVQPPKGPVRGQIARAYLYMGEQYGLRLAAQQRKLFEAWDRQYPADRWECERNRRIGKLQGNTNPFIEKQCQ
Endonuclease which is capable of degrading plasmid DNA.
Q44064
Q8BX94
OSBL2_MOUSE
Oxysterol-binding protein-related protein 2
Mus
MNGEEEFFDAVTGFDSDNSSIGEFSEANKISGMIDLDTSKSTRSGKNGEKPQQENGIQKHRTALPAPMFTRSDFSVWSILKKCIGLELSKITMPIAFNEPLSFLQRITEYMEHVYLIHKASSQSQPLERMQSVAAFAVSAVASQWERTGKPFNPLLGETYELIREDLGFRFISEQVSHHPPISAFYSEGLNQDFRFHGSIYPKLKFWGKSVEAEPRGTITLELLKHNEAYTWTNPTCCVHNVILGQLWIEQYGIVEIVNHRTGDKCILHFKPCGLFGKELHRVEGYIQDKNRKKLFIMYGKWTECLWGIDPASYESFKKQEKRGDQARKAKMDDGPEKANSDVPGDVADDVPVAQETVQVIPGSKLLWRINSRPPNSAQMYNFTSFTVSLNELESGMEKTLPPTDCRLRPDIRGMENGNMDLASQEKERLEEKQREARKERAKEDAEWRTRWFSPGNNPYTGAPDWLYAGHYFERNFSDCPDIY
Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro).
Q8BX94
Q045Z7
ECFA2_LACGA
Energy-coupling factor transporter ATP-binding protein EcfA2
Lactobacillus
MSIEFKNVDYIYAPGTPFQTQGLTNISFKIRSGSFVAIAGHTGSGKSTLMQHFDGLLLPSKGSVTIADKSITSNTSSKSLKEIRKKVGLVFQFPESQLFEETVLKDVMFGPLNFGFSEQKAKEQAIQWIRKVGLSEQVMNKSPFELSGGQMRRVAIAGVMAYEPDILCLDEPAAGLDPEGQKQMFDIFKNYQREGHTVILISHNMDDISQYADDMLVLEHGHLIKHASPKEVFSDPDWLKKHFLDEPATSKFARKLEKGGFQFSEMPLTVDSLVNEITTKLKSKGGNE
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Q045Z7
P21758
MSRE_BOVIN
Macrophage acetylated LDL receptor I and II
Bos
MAQWDDFPDQQEDTDSCTESVKFDARSVTALLPPHPKNGPTLQERMKSYKTALITLYLIVFVVLVPIIGIVAAQLLKWETKNCTVGSVNADISPSPEGKGNGSEDEMRFREAVMERMSNMESRIQYLSDNEANLLDAKNFQNFSITTDQRFNDVLFQLNSLLSSIQEHENIIGDISKSLVGLNTTVLDLQFSIETLNGRVQENAFKQQEEMRKLEERIYNASAEIKSLDEKQVYLEQEIKGEMKLLNNITNDLRLKDWEHSQTLKNITLLQGPPGPPGEKGDRGPPGQNGIPGFPGLIGTPGLKGDRGISGLPGVRGFPGPMGKTGKPGLNGQKGQKGEKGSGSMQRQSNTVRLVGGSGPHEGRVEIFHEGQWGTVCDDRWELRGGLVVCRSLGYKGVQSVHKRAYFGKGTGPIWLNEVFCFGKESSIEECRIRQWGVRACSHDEDAGVTCTT
Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).
P21758
B1HS22
LIPM_LYSSC
Octanoyl-[acyl-carrier-protein]:[GcvH] N-octanoyltransferase
Lysinibacillus
MTTWYFLNSGKCSPSFNMALDEALLDWHSEGLIPPVIRFYEWEPATLSIGYFQQAKKDINLDAVREQGLGFVRRPTGGRAVLHEHELTYSVIVTESYPDMPESVTEAYRVLSEGILQGFHNLGMDAYFSVPDTEEKRADLKSPKSAVCFDAPSWYELVVEGKKIAGSAQTRQKGVILQHGAILLDLDQEKLLSVFNFSSEEAKDRMRRKLPEKAVAINSLVDEPVTVEQCVTAFRDGFAKSLQIELKPFTLSEEQLEYVRALEEKKYACDEWNFKK
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation.
B1HS22
Q99PE4
P2RY4_MERUN
P2Y purinoceptor 4
Meriones
VHFSSSVMVLLFGLPFLVTLVCYGLMALRLCRPLPGAGQSSSRLRSLRTIAVVMTVFAVCLVPFHITRTIYYLARLLKADCQILNIVNVVYKVTRPLASANSCLDPLLYLFTGDKYRHQLQRLCRVSAPQRRITA
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by UDP.
Q99PE4
Q9SN68
RAF2B_ARATH
Ras-related protein Rab5B
Arabidopsis
MAAAGNKSINAKLVLLGDVGAGKSSLVLRFVKDQFVEFQESTIGAAFFSQTLAVNDATVKFEIWDTAGQERYHSLAPMYYRGAAAAIIVFDVTNQASFERAKKWVQELQAQGNPNMVMALAGNKSDLLDARKVTAEDAQTYAQENGLFFMETSAKTATNVKEIFYEIARRLPRVQPTENPTGMVLPDRAMDRAVSSSCCA
Endosomal protein that may be involved in endocytosis . Involved in the trafficking of proteins from prevacuolar compartments (PVCs) to vacuoles . May activate the MON1-CCZ1 complex which acts as guanine nucleotide exchange factors (GEF) for Rab7 protein family, and serves as a link between Rab5 and Rab7 families in PVCs, and mediates PVC maturation . Involved in vacuolar transport of storage proteins with EREX as effector. Regulates membrane trafficking to protein storage vacuoles (PSVs) .
Q9SN68
A1UUA9
RL20_BARBK
50S ribosomal protein L20
Bartonella
MARVKRGVTAHAKHKKILKQAEGFYGRRKNTIRAAKAAVDRSKQYAYRDRKNRKRTFRALWIQRINAAVRMEGLTYGRFIDGLSKAGIEIDRKVLSDIAIHEPTVFSALVASAKKALEYLKDTTPNAFEGAVK
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
A1UUA9
P50093
PHB2_CAEEL
Mitochondrial prohibitin complex protein 2
Caenorhabditis
MAKQGQEAMKKAIQNARGAGVGLGLVAAAGAAVYGVAQSMFTVEAGHRAIMFNRIGGLSTDLYKEGLHFRIPWFQYPIIYDIRARPNQIRSPTGSKDLQMVNIGLRVLSRPNPEHLVHIYRTLGQNWEERVLPSICNEVLKGVVAKFNASQLITQRQQVSMLVRKTLIERALDFNIILDDVSLTELAFSPQYSAAVEAKQVAAQEAQRATFYVERAKQQKQEKIVQAEGEAESAKLLGEAMKNDPGFLKLRKIRAAQKIARIVSESGNKTYLPTGGLMLNIADTDYLNVTDKRR
PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells . Required for clearance of paternal mitochondria after embryonic fertilization .
P50093
B2T740
RL24_PARPJ
50S ribosomal protein L24
Paraburkholderia
MNKIRKGDEVIVITGKDKGKRGVVLSVGEGKVIVEGINLVKKHVKPNPMKGTTGGVEAKTMPLQISNVALVDANGKASRVGIKVEGDKKVRFLKTTGAELSA
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
B2T740
Q5UXQ3
TRMY_HALMA
tRNA (pseudouridine(54)-N(1))-methyltransferase
Haloarcula
MRQFVIIGHDAPTTPEFSLDDLAGAAGRLDVLCRCVTSAFFLSHAIREDVRVHLILGDEYTVTFEGSDLRRLNPDERSTAALIRKALEEREEAIGHIPVETSPGVSLTRRGFEGTLDDVARRGTVVQLHEDGDPIVGVAPPSDPVFVLSDHHDFRDEEAALLADRADERVSLGPKALHADHSITVAHNYLDTAGFERY
Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs.
Q5UXQ3
Q56577
NHAB_VIBAL
Sodium/proton antiporter NhaB
Vibrio
MPISLGNAFIKNFLGKAPDWYKVAIIAFLIINPIVFFLINPFVAGWLLVAEFIFTLAMALKCYPLQPGGLLAIEAIAIGMTSPAQVKHELVANIEVLLLLVFMVAGIYFMKHLLLFIFTKILLGIRSKTLLSLAFCFAAAFLSAFLDALTVIAVVISVAIGFYSIYHKVASGNPIGDHDHTQDDTITELTRDDLENYRAFLRSLLMHAGVGTALGGVTTMVGEPQNLIIADQAGWLFGEFLIRMSPVTLPVFFCGLITCALVEKLKVFGYGAKLPNNVRQILVDFDNEERKTRTNQDVAKLWVQGLIAVWLIVALALHLAAVGLIGLSVIILATAFTGVIEEHSMGKAFEEALPFTALLAVFFSIVAVIIDQELFKPVIDAVLAVEDKGTQLALFYVANGLLSMVSDNVFVGTVYINEVKTALIEGLITREQFDLLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVIMALPYTIVLAIVGLMGIMFFLEPATASFYDAGWILPHSGDLTPVVSGGH
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Q56577
Q8PYZ8
HPPA1_METMA
Pyrophosphate-energized inorganic pyrophosphatase
Methanosarcina
MDMLIYLTPICALIGLIFAGISYKNVRNEGEGNELIKKITAAIHGGAMVYLNRQYRAIAVFVVFIAIVLALVLPNGVLTAACFVFGAVLSATAGYAGMLTATIANGRTTNAATRGIGPAFKVSFASGTVMGMSVVGLGLFGLSLSFIILGNIYTDMDLFTLLNIIAGFSFGASSIALFARVGGGIFTKAADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDIAGMGADLYESYVGSIIATMLLAASTAAATFPGIPVMNVVMVPLVIAAVGILASVIGTFFVRTNKTESSAIHMAFNMGLIAAIVLTVIASYVVTGHLLGGYGLNVFFSTVAGLVAGFLIGQITEHYTSYDKKPTLTVAHSCQTGSATNVITGFAKGMESTLWPAVIISIAIYIAFQLAGLYGIAIAAVGMLATLGISLSVDAYGPVADNAGGIAEMSHQKKEVRQITDTLDAVGNTTAAMGKGFAIGSAALTALSLFASYAIAVGLTSIDVMNPNVFIGLIIGAMLPFLFSSMTILAVGNAAGEVVVEVRRQFKEIKGLMEGKADPDYSKCITISTHSALKEMIPPGILAVIAPILVGLVLGAGALGGLLAGSVVSGFMLAITMSNAGGSWDNAKKFIELGNFGGKGSDAHKAGVTGDTVGDPFKDTAGPAINILIKLMSIVALVFAPLFI
Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.
Q8PYZ8
Q8K215
LYRM4_MOUSE
LYR motif-containing protein 4
Mus
MAASSRAQVLDLYRAMMRESKHFSAYNYRMYAVRRIRDAFRENKNVKDPVEIQALVNKAKRDLEIIRRQVHIGQLYSTDKLIIENQEKPRT
Required for nuclear and mitochondrial iron-sulfur protein biosynthesis.
Q8K215
Q1GB07
CRCB1_LACDA
Putative fluoride ion transporter CrcB 1
Lactobacillus
MDTVKNYLSVAFFAFWGGLARYGLTEAFSFYGTVIANLLGCFLLAFLTYFFLRKSNSRAWLTTGLGTGFVGAFTTFSSFNLDAFKLLLGGQNFGALLYFTGTIAAGFLFAWAGKQAANFAAGKLLERG
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Q1GB07
C1DBF4
SURE_LARHH
Nucleoside 5'-monophosphate phosphohydrolase
Laribacter
MRFLLSNDDGYFAPGIEALAAGLATLGTVTVVAPERDRSGASNSLTLDRPLMLRRAPNGFHFVNGTPTDCVHLAVTGMLDQQPDMVISGINHGANMGDDTVYSGTVAAATEGFLLGVPSLAVSLAAKPGEHLDTAVQVTLDIVRRMMDRPFTEPTLLNINVPDRPFHELRGTVATRLGRRHHAEPVVKSVNPRGDVVYWVGAAGPAQDAGEGTDFHAVREGFVSVTPLSIDLTGYRQLAELPAWLNP
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
C1DBF4
P23660
GUNA_RUMAL
Endo-1,4-beta-xylanase
Ruminococcus
MRKPDKDADRLTTLDLARSGEVRDISAMELVGEMKTGWNLGNSLDATGAPGNASEVNWGNPKTTKEMIDAVYNKGFDVIRIPVTWGGHVGDAPDYKIDDEWIARVQEVVNYAYDDGAYVIINSHHEEDWRIPDNEHIDAVDEKTAAIWKQVAERFKDYGDHLIFEGLNEPRVKGSPQEWNGGTEEGRRCVDRLNKTFLDTVRATGGNNEKRLLLMTTYASSSMSNVIKDTAIPEDDHIGFSIHAYTPYAFTYNANADWELFHWDDSHDGELVSLMTNLKENYLDKDIPVIITEYGAVNKDNNDEDRAKWVSSYIEYAELLGGIPCVWWDNGYYSSGNELFGIFDRNTCTWFTDTVTDAIIENAK
Hydrolyzes both carboxymethylcellulose and xylan. Probably has a role in hydrolyzing oligosaccharides derived from cellulose, which are transported across the cell wall.
P23660
Q9NVJ2
ARL8B_HUMAN
Novel small G protein indispensable for equal chromosome segregation 1
Homo
MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
(Microbial infection) During infection, coronaviruses such as SARS-CoV-2 and the chaperone HSPA5/GRP78 are probably co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress.
Q9NVJ2
Q6CZY7
RS5_PECAS
30S ribosomal protein S5
Pectobacterium
MAHIEKQAGELQEKLIAVNRVSKTVKGGRIFSFTALTVVGDGNGRVGFGYGKAREVPAAIQKAMEKARRNMMNVALNNGTLQHPVKGAHTGSRVFMQPASEGTGIIAGGAMRAVLEVAGVHNVLAKAYGSTNPINVVRATIDGLANMKSPEMVAAKRGKSVEEILG
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
Q6CZY7
P81007
ENT_ENTCO
Cytolytic protein enterolobin
Enterolobium
TQRDTLTKGMTQGQIVAGPDDTKIDQSIMDQGVCATIALPFDIHVAQSVKNVMFMFAWTQKHGLAVNNLVILGVPGYLNMWKRFGESTDEPSESSKRCCYEKPTDPVSGEIVTPAFDPADEISEITHQEESADIKPVRLLDARLLGYTWVTQNHSWIVAYSDEPIKDGNEVVTLRNIGNNNFCDALRKCTDKSACIHQYLQFAWNSFGDPTVRTRQVVFEVVGWADSDTTNNNSDTLFYRTTQADNWQVLTESKTNTIGLAEVDWFNFKYETKQEVSIEIARQTWTSTLNAGVSTVSRVPKVPIKVKINVDTFLKVLFAVYKADLYDIFLQFASVFKKGGNRQYWLNYTQEPNTKSNYNHKIYNDKIRYLQEDVQVHPNETQSKWWWWSFKKVALTTMTVVALTRFKASGINGQYISARQFSGGETVSPYRLAAPFDSCLWRRSPNPLGTDGLKVALAHHPLAGASNRNKLRVSIPAQCICSITA
Cytolytic protein with insecticidal activity. Acts as a pro-inflammatory agent.
P81007
Q2STU0
SAHH_BURTA
S-adenosyl-L-homocysteine hydrolase
pseudomallei group
MNAAVIDSNSAQDYVVADIALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGSKAEKDRSVIAKPTNEEEVALFKSIERHLEIDGSWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRESLVDGIKRATDVMIAGKIAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGNYHVINHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRVILLAEGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFTRGGEYANKVYVLPKHLDEKVARLHLARIGAQLSELSDDQAAYIGVPKAGPFKPDHYRY
May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
Q2STU0
C6DCC7
PCP_PECCP
Pyroglutamyl-peptidase I
Pectobacterium
MKTVLITAFEPFEGEAINPSWEAVKVLHQREVGGARVVACRLSCVFDLSLEELYRAIAEWQPEVVIAVGQAGGRTDISVERVAININDARIADNRGNQPIDTPIVEKGPAAYFSTLPVKALVQALRVAGIPASVSQTAGTFVCNHVMYGLLHQLHQQGDVVRGGFVHIPYSPEQAARHPGEPSMPTPLVTAALEVMIKQSLAQQVDVAVTGGALH
Removes 5-oxoproline from various penultimate amino acid residues except L-proline.
C6DCC7
A1K3X7
ACCA_AZOSB
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Azoarcus
MKTTFLDFEQPIAELEEKIEQLRFVQDDSAVDISEEIARLEVKSQALTKDLYAKLTPWQIAQVARHPQRPYTLDYVQHIFTDFEELHGDRAYADDKAIVGGLARFNGQSCVIIGHQKGRDTKEKIARNFGMPRPEGYRKAMRLMKLAEKFGLPVFTFVDTPGAYPGIGAEERGQSEAIGHNLYVMAELKVPLICTVIGEGGSGGALAIAVGDQVMMMQYSTYSVISPEGCASILWKSAEKASEAAETMGITAARLKSLGLVDKVVNEPVGGAHRDHRAAAQSLKRALAEALRQVDTLSPSELVEQRMEKLMGYGRFKEIAA
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
A1K3X7
O24973
ARSR_HELPY
Transcriptional regulatory protein ArsR
Helicobacter
MIEVLMIEDDIELAEFLSEFLLQHGIHVTNYDEPYTGISAANTQNYDLLLLDLTLPNLDGLEVCRRISKQKHIPIIISSARSDVEDKIKALDYGADDYLPKPYDPKELLARIQSLLRRSHKKEEVSEPGDANIFRVDKDSREVYMHEKKLDLTRAEYEILSLLISKKGYVFSRESIAIESESINPESSNKSIDVIIGRLRSKIEKNPKQPQYIISVRGIGYKLEY
Member of the two-component regulatory system ArsS/ArsR that regulates genes involved in biofilm formation and acid adaptation by acting on major ammonia-producing pathways . Upon phosphorylation by ArsS, functions as a transcription regulator by direct binding to promoter regions of target genes including ureA, amiE and amiF to positively regulate their expression in response to acidic pH . Negatively autoregulates its expression .
O24973
B0RUE7
MSRA_XANCB
Peptide-methionine (S)-S-oxide reductase
Xanthomonas
MLGIGAFKQRMPRSGEALPGRTQALPLHNTHLINGHPLRGEFTGLAQVQFGLGCFWGAERKFWNVPGVYTTAVGYAGGKTPNATYSEVCSGQTGHTEAVLVVYDAQAVSFEQLLRTFWESHDPTQGMQQGNDVGTQYRSAIYCSTQAQYDAAIASRDAYQQQLTAAGYGDITTEILYPAPTFYYAEDDHQQYLAKHPNGYCGLGGTGVSCPIGLDA
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
B0RUE7
Q92081
ACES_MYXGL
Acetylcholinesterase
Myxine
VPSPRPQNATVMVWIFGGGFAYGTSSLNVYDGRYLAQAEGAIVVSMNYRVGALGFLSLPGSPVPGNAGLFDQQLALRWVHGNIHRFGGNPQSVTLFGESAGSASVAPHLLSRHSQQFFQRAILQSGTLNAPWATVEDTEARRRAEALAQALGCPTDDDNELLNCLYARPPQEIVSKEGDVVIEPSIFRFPFVPVVDGHFIIDSPIVLLQQGIFKKTDLLLGVNRNEGSFFLIYGAPGFSKDHESLISREDFLENIPMIVPQGNEVSVDAIVLQYTDWLAQNDALKNRDAIEDIVGDYNVICPVVEMATRYAEFGNNVYFYFFNQRASNLPWPQWMGVI
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Q92081
B7SUM8
FBP12_RAT
Fatty acid-binding protein 12
Rattus
MVDQLQGTWKSVSCENFENYMKELGAGRAIRKLGCLARPVVTISTDGDRITIKTKSIFKNKEISFKLGEEFEEITPGGRKSKSTVVLDNDSLVQVQDWDGKEATIRRRLVDGKMVVESAVNNVTCTRTYQRV
May play a role in lipid transport.
B7SUM8
Q8BG02
2ABG_MOUSE
PP2A subunit B isoform gamma
Mus
MGEDTDTRKINHSFLRDHSYVTEADVISTVEFNHTGELLATGDKGGRVVIFQREPESKNAPHSQGEYDVYSTFQSHEPEFDYLKSLEIEEKINKIKWLPQQNAAHSLLSTNDKTIKLWKITERDKRPEGYNLKDEEGKLKDLSTVTSLQVPVLKPMDLMVEVSPRRTFANGHTYHINSISVNSDCETYMSADDLRINLWHLAITDRSFNIVDIKPANMEDLTEVITASEFHPHHCNLFVYSSSKGSLRLCDMRAAALCDKHSKLFEEPEDPSNRSFFSEIISSVSDVKFSHSGRYMLTRDYLTVKVWDLNMEARPIETYQVHDYLRSKLCSLYESDCIFDKFECAWNGSDSVIMTGAYNNFFRMFDRNTKRDVTLEASRESSKPRAVLKPRRVCVGGKRRRDDISVDSLDFTKKILHTAWHPAENIIAIAATNNLYIFQDKVNSDMH
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Q8BG02
Q8XE76
DXS_ECO57
1-deoxyxylulose-5-phosphate synthase
Escherichia
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDETLILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Q8XE76
P10146
CCL1_MOUSE
T-cell activation protein 3
Mus
MKPTAMALMCLLLAAVWIQDVDSKSMLTVSNSCCLNTLKKELPLKFIQCYRKMGSSCPDPPAVVFRLNKGRESCASTNKTWVQNHLKKVNPC
Cytokine that is chemotactic for neutrophils.
P10146
Q3SSY3
RL1_NITWN
50S ribosomal protein L1
Nitrobacter
MATGKRLKKSREGIDRNKLYPIADAIRMVKERATSKFDETIEIAMNLGVDPRHADQMVRGVVTLPNGTGRTLRVGVFARGAKAEEAKAAGADVVGAEDLVETVQGGTIAFDRCIATPDMMPLVGRLGKVLGPRGMMPNPKIGTVTMDVAGAVKGAKGGSVEFRVEKAGIVQAGIGKASFSAEKLVENVKALADAVAKAKPAGAKGTYVQRIAVSSTMGPGVKVEPGTVLG
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
Q3SSY3
Q06575
HP20_TAMSI
Hibernator-specific blood complex 20 kDa subunit
Tamias
MTDVWRLAIFVLMVNVLNDQVSCSGPPGPVGYPGVPGVPGPRGPPGQPGAAGRPGDPGPKGPSVKCPCRERSAFTVKFSGRLPPPSEPVVFTEVLYNTQRDLKESTGVFNCVEPGNYHFSFDVELYHCKVKIGLMKNHIQVMEKHQLSKNEYENASGAMIMPLRQGDKVWLEADVETEEPDQAKVVIYFSGFLISS
Plasma proteins HP-20, HP-25, HP-27 and HP-55 form a 140 kDa complex via disulfide bonds in the plasma and are hibernation specific.
Q06575
A8LPA8
HSLV_DINSH
ATP-dependent protease subunit HslV
Dinoroseobacter
MTETSFPGWHGTTIIGVKKNGKVVVAGDGQVSLGQTVIKGTARKVRRLTPGGHDVVAGFAGSTADAFTLLERLEAKLEATPGQLQRAAVELAKDWRTDKYLQKLEAMLIVTDGSLLLVITGAGDVLEPEHDIAAIGSGGNFALAAARGLMEADFDAETIARKAMQIAADICVYTNGNLTVEAIDA
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
A8LPA8
Q17Z31
RS6_HELAH
30S ribosomal protein S6
Helicobacter
MRHYETMFILKPTLVEEEIKSKIEFYKEVITKHNGVIETSLDMGMRNLAYEIKKHKRGYYYVMYFKAEPSMILELERLYRINEDVLRFIVIKYDSKKEVEAWHALVDRANKKPSHAKEKHEKTEHAHSHHTEEAGSKESHSE
Binds together with S18 to 16S ribosomal RNA.
Q17Z31
Q85WT6
CHLL_PINKO
Light-independent protochlorophyllide reductase iron-sulfur ATP-binding protein
Pinus subgen. Strobus
MKIAVYGKGGIGKSTTSCNISVALARRGQKVLQIGCDPKHDSTFTLTGFLIPTIIDTLQSKDYHYEDIWPEDVIHKGYGGVDCVEAGGPPAGAGCGGYVVGETVKLLKELNAFYEYDIILFDVLGDVVCGGFAAPLNYADYCVIITDNGFDALFAANRITASIREKARTHPLRLAGLVGNRTSRRDLINKYVEACPMPVIEVLPIIEDIRVSRVKGKTLFEMVGSEPSLNYVCNYYLGIADQILSQPEGIVPKEIPDRELFSLLSDLYLNPIGGGGQKKKIQENFLGFTRI
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP.
Q85WT6
A2XVI8
G1L4_ORYSI
Protein G1-like4
Oryza sativa
MDLSPNPDSPPSGGGNGGGGGSSSSNSSPSMGAGAPQSPSRYEAQKRRDWNTFGQYLRNHRPPLSLAQCSGAHVLEFLRYLDQFGKTKVHTAACPFFGHPSPPAPCPCPLRQAWGSLDALVGRLRAAFEENGGRPESNPFAARAVRLYLREVREHQARARGVSYEKKKRKKPQQQQLQGGDSSGLHGHQHHPPPPPPAGAAC
Probable transcription regulator that acts as a developmental regulator by promoting cell growth in response to light.
A2XVI8
A1RLV3
DXS_SHESW
1-deoxyxylulose-5-phosphate synthase
Shewanella
MSLDISQFPVLAQANTPNELRQLPQALLPQVADELREFLLKSVGMSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDKMHTIRQKNGLHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTLREGGKKVLKGMPVIKEMAKRTEEHLKGMVVPGTLFEELGFNYIGPIDGHDVDALVETMRNMRNLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPTQFKKPSTTPGLPTFSQVFGKWLCDIAEQDDKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGYDQLIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYNAGPSAVRYPRGSATGATQVEAMTALPIGKGVIKRVGKRIALLNFGTTLASALTAADNLDATVVDMRFVKPLDAELVTEMAQTHDILVTVEENAIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEEVTHDLQLDAEGILAQINAYLAQ
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
A1RLV3
P19338
NUCL_HUMAN
Protein C23
Homo
MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
P19338
Q9SU05
KIB1_ARATH
Protein KINK SUPPRESSED IN BZR1-1D 1
Arabidopsis
MTHKKQKKEMSDSEKKTFNEDSKHSILAVDLVRLILERLSFVDFHRARCVSSIWYIASKTVIGVTNPTTPWLILFPKGDVEIKKDSCKLYDPHENKTYIVRDLGFDLVTSRCLASSGSWFLMLDHRTEFHLLNLFTRVRIPLPSLESTRGSDIKIGNAVLWVDEQRKDYLVVWNISSLFGYHKKGDDRWKVFKPLENERCIIAMVFKENKLYVLSVDGNVDVFYFSGNDSPVRCATLPSSPLRKGHKVVVTLSGEVLIIVAKVEPYPRTRLCFFAVYKMDPKSSRWETIKSLAGEALILDLGITVEAKVMKNCIYFSNDQFHRYNENSLWNVSNKSGVFVYHFRSANVVQLVELLTASSRTSKILFKDARCFFPTFTSKWLL
Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Required for brassinosteroid (BR) signal transduction. Mediates ASK7/BIN2/SK21 inactivation both by competing with substrate binding (e.g. BZR1) and by promoting its ubiquitination and subsequent proteasomal degradation.
Q9SU05
Q0WUV7
EXL4_ARATH
Family II extracellular lipase 4
Arabidopsis
MCSKITLVLTLFSSYFISTDAVNGSFPALLAFGDSILDTGNNNFLLTFMKGNIWPYGRSFSMRRATGRFGNGRVFSDIVAEGLGIKKILPAYRKLFNSPSDLRTGVCFASGGAGVDPVTSKLLRVLTPKDQVNDFKGYIRKLKATAGPSRASSIVSNAVILVSQGNNDIGISYFGTPTAAFRGLTPNRYTTKLAGWNKQFMKELYDQGARKFAVMGVIPLGCLPMTRIFLGGFVITCNFFANRVAEQYNGKLRSGTKSWGREAGFRGAKFVYVDMYNTLMDVIKNYRRYGFSNEKNGCCCMITAIIPCPNPDKYVFYDFVHPSEKAYRTISKKLVQDIKNGLA
Required for the formation of pollen coats and male fertility.
Q0WUV7
B2SBS2
MINC_BRUA1
Probable septum site-determining protein MinC
Brucella
MNQVLTETRPIRLKGRSFLAMVLSPELPLDGWLERLDDLARRSSGFFLGRPVVLDMENLAIERAQLVYLLQALNDRGVWIMGVEGARPSLLGPGMPPAMRGGQPAADFEAPAGEPQANPGAPEPQISQAVRAPGHAVHAMPSMVITEPVRSGQSVYFPEGDVTIVGSVASGAEVVAGGSIHIYGTLRGRALAGTAGNTSARIFCRKLEAELVAIDGLYKTAEDLEPRFRGQAVQLWLDGDYMMIDTLS
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
B2SBS2
B8HNM9
PYRG_CYAP4
UTP--ammonia ligase
unclassified Cyanothece
MTKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYSVSILKLDPYINVDPGTMSPFQHGEVFVTDDGAETDLDLGHYERFTDTAMSRLNSVTTGSIYQAVLNKERRGDYMGGTVQVIPHITNEIKDRILRVAKDTNPDVVIIEIGGTVGDIESLPFLEAIRQFRTEVGRQNVLYMHVTLIPWIPSAGEMKTKPTQHSVKELRSIGIQPDILVCRCDRPLYPGIKDKMSQFCDVPVKSVITCQDARSIYEVPLILEREGLAAQVLSLLNLEQRTPDLSEWQSLVEQLYRPKPPVEIAIVGKYVRLTDAYLSVMEALRHAAIAVGCELNLRWINSEDLENNNPEAYLGGVTGVVVPGGFGIRGVDGKIAAIRYAREHQIPFLGLCLGMQCCVIEWARSIAKLTDANSAEFDPQTSNPVINLLPEQQDVEVLGGTMRLGLYPCRLLSNSLAYQLYQETVIYERHRHRYEFNNAYRNLFLDTGFVVSGSSPDGRLVEIIELPEHPFFIATQFHPEFRSRPNVPHPLFKGFVQAARTHSSDRSNGHTPSETPSLSV
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
B8HNM9
Q01703
MSXC_DANRE
Homeobox protein MSH-C
Danio
MAPLSSMMNSLQGPLSQEGKLQERKSDKEDAQSNDKAAVKGCKGKALSLPFSVESLISDRTSSRTLYTSSEAGIISPTSGADERLKLSPMALYADRKIPVESVSNLSDCKRGDMEELSDKGQSGWFQTTSYTSPPRHSSPPPCTLRKHKNNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSNSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKLATKPLLPAFAFPFPLGTHVGSPPLYGPSSSFPRPALPVPGLFGGPVTYGMYYLS
Involved in the development of the inner ear.
Q01703
B5FGX4
DAPA_ALIFM
4-hydroxy-tetrahydrodipicolinate synthase
Aliivibrio
MFSGSIVALVTPLDTDGEVDYNSLKSLVDYHIKAGTNGIVAVGTTGESATLSVEEHVKLVMKTLEFADGRIPVIAGTGANATHEAVTFSKLFHDSGVAGCLSVTPYYNKPTQEGLFQHYKAISEATDIPQILYNVPGRTAVDLLPETVARLAELDNIVALKDATGDLERVAITRELCGENFIQLSGDDATALDFVKLGGHGVISVTSNIAAKDMATMFALAAQGKFEEAEIINQRLMPLHNDLFVEANPIPVKWAAHRLGMITHSDIRLPLTELSLSAQPTVEQALKSAGLLK
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
B5FGX4
O66662
MURI_AQUAE
Glutamate racemase
Aquifex
MKIGIFDSGAGGMTVLKAIREAYPNVDVVYLGDTARVPYGIRSKETIVRYSKECANFLKDKGVDLLVVACNTASAYALEELKREFPFPVFGVIEPGVKEALRKSKTKRIGVIGTQATIKSGAYQEALKRAGAEVYSKACPLFVPLVEEGMIEGEIPKKVVEHYLKDFKGKVDTLILGCTHYPLLKREIQNFLEGVNVIDSSRATAKSLKDFVKNEGSGSLELYFTDRSQNLERLIKLILGEEVEPKITSEVFVL
Provides the (R)-glutamate required for cell wall biosynthesis.
O66662
F1LV46
I23O2_RAT
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Rattus
MEAQRQDGKLASSLSLGKYHISEEYGFLLPNPLEELPDHYKPWMEIAHRLPHLIESHQLQAHVYEMPLLDCRFLTSYREQRLAHLVLAAITMGFVWQEGEAQPQKVLPRTLAIPFVEVSRSLGLPPILVHSDLVLTNWTKRNPEGPLEIGNLETIISFPGGESLQGFILVTVLVEKAAVPGIKALVLGVEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPEIFYLVIRIFLSGWKDNPVMPVGLVYEGVSTEPLKYSGGSAAQSSVLHAFDEFLGIQHCKESVDFLHRMRDYMPPSHKAFLEDLHSAPSLRDYILDSGPGGCLMAYNQCVEALGELRSYHINMVARYIISAASKARSRMLTRLSPHALEDRGTGGTAVLSFLKSVREKTMEAILCPGA
Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Involved in immune regulation.
F1LV46
Q9PTY5
RANB9_XENLA
Ran-binding protein M
Xenopus
MSSPPLHGLSSVGHLSRDPPPRSWSPRDKCSYLGLSHGNLRVHYKGHGKTSKDAASVRSTHPIPAACGIFYFEVKIISKGRDGYMGIGLSTQGVNLNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLIDNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQSPFVFDIEDYIREWRSKIQAQIERFPVAGEWQSMIQRMVSSYLVHHGYCSTAEAFAKSTDQTVQEELASIKNRQRIQKLVLSGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGNRSLKSPDGCLGSDSNCSNGIISNKAHQTHCHSKSQSSNLNVTELNSINMTMSHQLNSYSSNDVEMETDHYSNGFSASTSNGFLNGSSRHEPELEECDTEMEVDTSHGRRQLCGGSQAAVERMICFGRELQAMSEQLRRERGKNATNKNMLKDAFSLLAYSDPWNSPVGYQLDPIQREHVCSSLNSAILDIHNLPKQPPLSLALEQASQCLEMMAQCGIGSCAFARVADYLH
May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins.
Q9PTY5
Q8TSZ5
PRIS_METAC
DNA primase small subunit PriS
Methanosarcina
MDKRTTQFLKSRFQSYYKNAEIGLPDHLPNREWAFIFYDDMPEKMMHRHKSFGSPGEALDYLYGMAPAHVYNSTAYYEYPDAKKMNEKNWLGAELIFDLDADHLPNAPRNYADMLELVKKEALKLLDFLLDDFGFSEQEIQLVFSGGRGYHFHIVSPKVLTLGSSERREIVNYVSGRDLEFKYFFREVAMDGDFGTGSKTFKGMKNVPMKCTLVGYDSGWGRRIALYLTDYMKRESEKKYKKDMFPELRRHEKVGDTTIKKLINIANSETGLKDILEKGRLDFDVRNFKEIAAYFMQESAEDFLHRFGASVDEPVTADIKRLIRVPGSLHGGSGMLVKKLALSELEEFDPLNDAVVFGERPVKITASKPFSVQLKGKDLRIEEGIQEVPEYAAVYLICRGVAEYGHRRNQPDTV
Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
Q8TSZ5
A7H2Q3
ISPE_CAMJD
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Campylobacter
MKAYAKANIFLKLTGFDSRKYHLLESRFILLKDVFDELELVDKESDSKKEFEIISNFKCENNIIQKAYLLLSRRYNNELKELFSKKSLKLTKNIPVCAGLGGGSSDCASFLLLMNETLNLKLNLQELINLSIQLGSDIAFFLSGFNSANVSGCGEIIEEFEDDIPTLKWTFPQISCQTKAVYDEFDREIFDFQKNNNQAQIYKKLSTKELLQNFKNKELNDLFTPCATLYPKMKSYLQEDFFLSGSGSSVFKVDR
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
A7H2Q3
Q7T3B0
EIF3M_DANRE
Eukaryotic translation initiation factor 3 subunit M
Danio
MSVPAFIDITEEDQASELRSYLKSKGAEISEENSEGGLHVDLAQIIEACDVCLKDDDKDVESVMNSIVSLLLILETEKQEALIESLCEKLVKFREGERPSLRMQLLSNLFHGMDENTPVRHTVYCSLIKVAATCNAITFMPTDLDQVRKWIVDWNLNTEKKHTLLRLVYEALVDCKKSEAAAKVMVELLGSYTEDNASQARVDAHRCIVRALKDPNTYLFDHLLALKPVRFLEGELIHDLLTIFVSAKLISYVKFYQSNKDFIESLGLSHEQNMSKMRLLTFMGMAVEMKEISFETMQQELQIGAEDVEAFVIDAVRTKMVYSKIDQTQRKVVVSHSTHRTFGKQQWQQLYDTLCSWKQNLSTVKSSLQTLSPTA
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Q7T3B0
Q8RIL0
MRNCL_FUSNN
Mini-ribonuclease 3-like protein
Fusobacterium
MDNVDFSKDIRDYSGLELAFLGDAIWELEIRKYYLQFGYNIPTLNKYVKAKVNAKYQSLIYKKIINDLDEEFKVIGKRAKNSNIKTFPRSCTVMEYKEATALEAIIGAMYLLKKEEEIKKIINIVIKGE
Might be a ribonuclease involved in RNA processing.
Q8RIL0
B5RN32
SYI_BORDL
Isoleucyl-tRNA synthetase
Borrelia
MFKKVENKVHFPQLEEKILQFWNDNKIFEKSMKQREGCEEFTFYDGPPFATGLPHFGHFVPNTIKDIIPRYQTMKGKHVKRYFGWDTHGLPVEYEVEKSLKLSGRYEIEQYGIDKFNEECRNIVLRYTKEWKKIITRLGRWVDFENNYKTMDLTFMESVWWVFKTLYNKGLIYESYYVLPYSPKLATPLSNFEVNLGEYKEIHDPSLTIKFKIKDKNEYLLAWTTTPWTLPTNLGIAVGKDIDYSKVLDQEKNEIYIIGTKRLNHYYQDENKYVIIEQFKGEHLKGIEYEPLFDYFVNQRNKGAFKIHTAEYVTTDDGTGIVHIAPFGEEDYQILKKNTQTDMITPIDAECKFTSEVKDFEGLFVKDADNKIIEKLKSMNLLFKRENYLHRYPFCYRTNSPLIYRPISSWFVNIEKIKEKLIRSNEQINWIPEHLKKGRFGKWLENARDWAISRNRFWGNPIPIWKCSKTGNKICIGSREELEKLSGQKIIDLHKDKIDKITWPSKYGGTYVRTSEVLDCWFESGSMPYASKHYPFKDKDKFQNIFPADFIAEGLDQTRGWFYTLTILGTALFEKTAFKNVIVNGLVLSSDGKKMSKSLKNYTDPIQIINTFGADALRLYLIMSPVIKADDLKYSDDGVKDVLKNIIIPIWNAYSFFITYAIIDKFTPNNHVNLYKTNILDKWIISEIESLKQILNEEIDKYNLTKSIDVLLTFIDKLNNWYIRRSRRRFWKSENDNDKTDAYETLYYTLKNLMLMLAPFIPFLTEEIYQNLKTKNEKESIHLNDYPQSIKELINIELEEKMNFTRKVITIARALRASHNIKIRKPIKTIYIITKNHKEQNTLREMTEIILEEINAKEIKIKSNEEELVTYKAKANFKELGSKLGTNMKSVALAITKLSNEDILEIINGNKHTITINNNTYDITLKDIILERHERKNLKVINEDSITIGLDTLITEELYLEGLSRELIRKVQNLRKESNFNVTDRIILYTNNDEILTKIINNFENYIKTETLAITIEINNKKALKTLELDEEISVNIGIEKCLN
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
B5RN32
Q2G0N5
RPOC_STAA8
Transcriptase subunit beta'
Staphylococcus
MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWECSCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDMSPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLEEIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKEMALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVHASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRYFIDPTTLGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGITVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGELMQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMIEPFIERIEGRYSKETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARHGVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRIQEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQPVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQKVYRMQGVEIDDKHVEVMVRQMLRKVRIIEAGDTKLLPGSLVDIHNFTDANREAFKHRKRPATAKPVLLGITKASLETESFLSAASFQETTRVLTDAAIKGKRDDLLGLKENVIIGKLIPAGTGMRRYSDVKYEKTAKPVAEVESQTEVTE
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q2G0N5
B5ZS19
ATPF1_RHILW
F-type ATPase subunit b 1
Rhizobium
MEFHFDATFFAFVGLVLFLALVVYLKVPGMMARSLDDRADQIRNELAEAKRLREEAQHLLAEYQRKRKEAEAEAAHIVAAAEREAQMLTAEAKKKTEEFVANRTALSEQKIKQAEVEAMKAVRSAAVDLAIAAAETVLGKQADAKVQSELFGNAVGQVKTRLN
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
B5ZS19
B9MAC9
NRDR_ACIET
null
Diaphorobacter
MKCPFCSHQETQVVETRVSEDGDFIRRRRQCGACDKRFTTYERPEVNFPTVVKKDGRRVEYDREKLLGSFKLALRKRPVSTVQIDSAIERIEEKLLNLGQREILSSRIGELVMRELKKLDKVAYVRYASVYRSFEDIDEFRALVDEVRK
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
B9MAC9
P60865
FOSB_BACCE
Fosfomycin resistance protein
Bacillus cereus group
MIQSINHICFSVANLEKAIEFYQNILQAKLLVKGRKLAYFDLNGLWIALNVEESIPRNEIQYSYTHIAFTVTNNEFDSLKEILIQNQVNILPGRERDDRDKRSIYFTDPDGHKFEFHTGTLQDRLQYYKEDKKYMTFY
Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.
P60865
B0CJ70
THIG_BRUSI
Thiazole synthase
Brucella
MLEFYGKRFESRLLLGTAQYPSPSILADAVRASLSRTVTVSLRRESGEARAGQDFWALIKALGVAVLPNTAGCHTPREAITTAHMAREVFGTNWIKLEVIGDTDTLQPDPFGLVEAARILCDEGFEVFPYMNDDLIVAERLIEAGCKVLMPWGAPIGSGRGLNNPYALKTMRAHFPDIPLVVDAGIGVPSHAAAAMELGFDAVLINTAVAKAGDPAAMARAFALAVEAGRLAYEADPIEARDMASPSTPLLGKAFL
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
B0CJ70
O31714
K1PF_BACSU
Fructose 1-phosphate kinase
Bacillus
MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSRLLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEINGQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVLDISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSMAGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSGSATAFSEELGTEEFVQQLLPEVKVTRL
Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate.
O31714
C0Q328
NHAB_SALPC
Sodium/proton antiporter NhaB
Salmonella
MEISWGRAMWRNFLGQSPDWYKLALLVFLIVNPFIFLANPFIAGWLLVAEFIFTLAMALKCYPLLPGGLLAIEAVIIGMTSAAHVREEVAANLEVLLLLMFMVAGIYFMKQLLLFIFTRLLLSIRSKMVLSLAFCVAAAFLSAFLDALTVVAVVISVAVGFYGIYHRVASSRGEENDMLDDSHIDPHYKTVLEQFRGFLRSLMMHAGVGTALGGVMTMVGEPQNLIIAKAAGWHFGDFFLRMSPVTVPVLVCGLLTCMLVEKMRWFGYGETLPEKVRDVLQQFDDQSRKKRTRQDKIKLIVQAVIGVWLVTALALHLAEVGLIGLSVIILATALTGVTDEHAIGKAFTESLPFTALLTVFFSIVAVIIDQHLFAPIIQFVLQASEHAQLTLFYLFNGLLSSISDNVFVGTIYINEAKAAMENGAISLKQFELLAVAINTGTNLPSVATPNGQAAFLFLLTSALAPLIRLSYGRMVWMALPYTIVLTLIGLLCVEFTLAPATEWMTQAGWLATLS
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
C0Q328
Q5SW45
MKS1_MOUSE
Meckel syndrome type 1 protein homolog
Mus
MAEAVWSTDTGEAVYRSRDPVRNLRLRVHLQRITSSNFLHYQPAAQMGKDLIDLATFRPPQAASGHRPDEEEEEEVVIGWQEKLFSQFEVDLYQNESACQSPLDHQYRQEILKLENSGGRKNRRIFTYTDSDRYTDLEEYCQKITTSASEVPSFLAERMANVRRRRQDRRGVEGSKLKSRIVTWEPSEDFIKNNHAINTPLQTMYIMADLGPYGKLGYKVHEHVLCILKVDSNGVITVKPDFTGIKGPYRIETEGEKQEHTSAWKYTIDNVSSLAQPEEEEREQRVFKDLYGRHKEYLSSLVGTDFEMIAPGALRLFVNGEVVSAQGYEYDNLYVHFFVELPAANWSSPPFQQLSGVTQACATKSLGMDKVAYFSFPFTFEAFFLHEDESAESLPEWPVLYCKVLSLDFWQRYRVEGYGAVVLPATPGSHTLTVSTWRPMELGLVAELRRFFIGGSLELEDPSYVRIPGTFKGERLSRFGFRTETTGTVTFRLHCLQQSRAFMESNSLQKQMRSVLDRLEGFSQQSSTHNVLEAFRRARRRMQEARESLPQDLVSPTGTLT
Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology.
Q5SW45
Q8Y7S7
CBID_LISMO
Cobalt-precorrin-6A synthase
Listeria
MEDFIYYNGKKYRKGYTTGTCAAAAAKACVEMILTQEEVSAVQVTTTGGTILEIPVAYQKFSKDKATAAVQKDGGDDIDATHGMWIFVDIDLTDNAEVVLDGGVGIGRATQKGISVAVGEAAINPAPRKNILATVRESLGENRGAKILVYAPEGEERAKRTMNSNLGIIGGISILGTTGIVTPMSDEGWKKSLSMELEMKRNQGLDQIILVPGNYGDDFVQNTLGFSSGNIVSMSNFVGYMLKETQRLAFKKVLMVGHFGKLVKVSAGIFTTYSKDADARAEILVANLALLGAPLSLLQAVEKCNTTEAAGELIEEAGFTQVYEVIAQKIKARSERFLKFTKPSVEIDVVTFSTERGLLAATKDIDVLREEWR
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
Q8Y7S7
A0A0P0V5U9
YUC1_ORYSJ
Flavin-containing monooxygenase YUCCA1
Oryza sativa
MDNKPAQERRETWVPGAVIVGAGPSGLAAAACLAARGVPATVLERSDSLASTWRHRMYDRLALHLPKRFCELPLLPFPEEYPTYPSKDQFVAYMEAYAAAAGVAPRFGATVEEAAFDAAVGAWRVRLDGGEVLMARWLVVATGENAEPRVPDFPGMQKFAGCAMHTSEYKSGEQFAGKKVLVVGCGNSGMEVSLDLCRHGAKPSMVVRNTVHVLPREMFGLSTFGIAMALLRWLPVQLVDRFLLTAAHLILGNTGQFGLRRPKTGPIELKNLTGRTPVLDVGTLDHIKSGKIKVVGAVKEMTRQGVRFTDGKEEQFDTIILATGYRSNVPSWLKDAGDLFTREGISKVPFPNSWRGRNGLYTVGFTQRGLLGTSSDALNVAKDIHCQWRERDRSAINVLEISNSSF
Involved in auxin biosynthesis . Converts the indole-3-pyruvic acid (IPA) produced by the TAA family to indole-3-acetic acid (IAA) (Probable). Functions downstream of TAR2 in auxin biosynthesis . Functions upstream of WOX11, a transcription factor that promotes the development of crown roots .
A0A0P0V5U9