accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
A8LM72
RL6_DINSH
50S ribosomal protein L6
Dinoroseobacter
MSRIGKKPVELPTGVTASVSGQTIEVKGPKATRSFTATDDVTLKVEDNVITIEPRGKSKRARQQWGMSRTMVGNLVTGVTNGFKKELEIQGVGYRAQMQGNTLKLNLGLSHEVNYEVPAGVTVTCPKVTEIVIEGTDEQLVGQVAANIRDWRKPEPYKGKGIRYKGEFIFRKEGKKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
A8LM72
A5FQR6
IF2_DEHMB
Translation initiation factor IF-2
Dehalococcoides
MVEKTSKPSAKTEVAPPVKIIELGAAVSVKELADSLETNPVEVIKALMRKGIMANINQVIDFDIAKGVIEAAGFEAKLKILKKSAAKKASPAKEKLSNFPLRPPVVTIMGHVDHGKTRLLDAIRSTNVMEKEVGGITQHIGAYQVEIKGHKITFLDTPGHEAFTAMRARGAQATDITILVVAADDGVMPQTLEALDHAKAAGVPIILAINKMDKPEANPDRVKQQLAEVGLVVEEWGGDTLAIPTSARENKGINELLEAVLLIAELEDLRADPNQPASGVVIEAEMDKTKGPMATVLVQSGTLKLGDTVVAGNTWGRVKAMFNDVGKRIKKAEPSTPVALLGMESVPQVGDKIIAVATEKQARDMVNENSQSTRKTNAVSLTNVYDQVSQGNIKELNIILKTDVQGSLEPIKDSLEKLSTDKIKININRSGAGNVTESDVMLAMASGGLIIGFSTGIETNAQRLADAEDIDIRHYDIIYKLIEDVDKALQGLLEPTIKEVIDGRAEVRAVFESTKKLSIAGCMVLEGKLVKNSQVRLLRGGEVIVDAPSNSLRRFKEDVKEVVAGYECGVGLKDFNEFQKSDILEFYHKEKSR
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A5FQR6
Q8I1A6
SH3G3_DROWI
SH3 domain-containing GRB2-like protein
Sophophora
MAFAGLKKQINKANQYMTEKMGGAEGTKLDMDFMEMERKTDVTVELVEELQLKTKEFLQPNPTARAKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAKDDEIRGAEDKFGESLQLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRSEAESRPRNEFVPKTLLDLNLDGGGGGLNEDGTPSHISSSASPLPSPMRSPAKSMAVTPQRQQQPCCQALYDFDPENPGELGFKENDIITLLNRVDDNWYEGSVNGRTGYFPQSYVQVQVPLP
Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis.
Q8I1A6
P54404
TBG2_EUPCR
Gamma-2-tubulin
Moneuplotes
MPREIITCQVGQCGNQIGMEFWKQLCMEHGISPEGILEEYALDGEDRKDVFFYQADDEHYVPRAVLIDLEPGVIKQIQNSPYSNLYNPENFFVSKTMDGAGNNWAKGYCEGAKYEEEIIEMIDREADGSDSLEGFVLTHSIAGGTGSGFGSYLLEKLNDHYPKKLVQTYSVFPNDNDIVVQPYNCILSMKRLVLNADCVVVLDNTAITSIAVDRLKLLHPTISQVNSIVSTVMAASTTTLRYPGYMNNDLVGLIASLVPTPRCHFLMTGYTPLSLNDQKVSSIRKTTVLDVMRRLLQTRNIMTSGAIKKGAYMSILNIIQGDVDPTQVHKSLQRIRERNVANFIPWGPASIQVALSKKSPYIESDNKVSGLMLANHTGIRSIFQVLYGQYRQFRKRDAFLGTYRETKIFQDNLDEFDSSEEVVKDLIDEYAAAEKMDYINRGKDDEDMDYDPRAPPNFRPIE
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
P54404
Q95A26
ATP6_PONPY
F-ATPase protein 6
Pongo
MNEDLFTPFTTPTVLGLPAAILVILFPPLLVPTSKHFINNRLITTQQWLIRLTLKQMMITHNTKGRTWSLMLTSLIIFIASTNLLGLFPYSFTPTTQLSMNLAMAIPLWASTVAMGLRFKAKISLAHLLPQGTPTPLIPMLIIIETISLFIQPLALAVRLTANITAGHLLMHLIGSATLTMLTINLPLTLITLTILTLLTILEIAVALIQAYVFTLLVSLYLHDNS
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Q95A26
A1VRR7
TRPB_POLNA
Tryptophan synthase beta chain
Polaromonas
MYDYHQPDLAGHFGIYGGSFVSETLTHAINELKDAYARYQNDPKFLAEFNYELKHFVGRPSPIYHAARMSREQGGAQIYLKREDLNHTGAHKINNTIGQAMLARRMGKQRIIAETGAGQHGVATATICARYGLECVVYMGSEDVKRQSPNVYRMNLLGATVVPVESGSKTLKDALNEAMRDWVANVDNTFYIIGTVAGPHPYPMMVRDFQSVIGTECLSQMPEMNAGRQPDAVVACVGGGSNAMGIFHPYIAHENTRLIGVEAAGEGLDSGKHSASLQRGLPGVLHGNRTYVLQNDDGQVTETHSISAGLDYPGVGPEHAYLKDIGRAEYVGITDTEALQAFHYLCRTEGIIPALESAHAVAYAMKLAKTMRSDQSILVNLSGRGDKDIGTVADLSGADFYDRPSMRGLGVKGGVATSPESFDASGAKGAGSQS
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
A1VRR7
Q09FP7
RK23_NANDO
50S ribosomal protein L23, chloroplastic
Nandina
MDGIKYAVFTDKSIRLLGNNQYTSNVESGSTRTEIKHWVELFFGVKVIAMNSHRLPGKGRRMGPIMGHTMHYRRMIITLQPGYSIPPLRKKRT
Binds to 23S rRNA.
Q09FP7
Q1GK14
RL6_RUEST
50S ribosomal protein L6
unclassified Ruegeria
MSRIGKKPVELPSGVSASLSGQTIEVKGPKGAQTFTATDDVTLTVEDNVVKVEPRGKSKRARQQWGMSRTMVANMVQGVTQGFKKELEIQGVGYRAQMQGNTLKLNLGYSHDVDFTAPEGVTITAPKQTEIVVEGADAQAVGEVAAKIRDWRRPEPYKGKGIRYKGEFIFRKEGKKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q1GK14
O33509
FMT_RICAK
Methionyl-tRNA formyltransferase
spotted fever group
YFSYNDKVIKILEAEYLNTIHHVTAGTVISDKLEIACGSGILQVKKLQQESKKALNVEEFLRGTNILKATILK
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
O33509
Q3T165
PHB1_BOVIN
Prohibitin 1
Bos
MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.
Q3T165
Q3E9B4
OFP8_ARATH
Ovate family protein 8
Arabidopsis
MEKRMKLRVSRIVRSSLSSCRPRDLYDVVETCAVTSKATSSERFFVTKAKTKTPSRPKSHASSCPRASPIFPPNPFYEESRSFRDLRKKVKTNRKQRSQFGSDPLFASRFKSTGSWYWSCSEEEDEGDKEESEDDDSDTLFSSRSFSSDSSKAESFAVVKKSKDPYEDFRTSMVEMIVERQIFAPAELQQLLQCFLSLNSRQHHKVIVQVFLEIYATLFSP
Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
Q3E9B4
B6J8N7
SUCC_COXB1
Succinyl-CoA synthetase subunit beta
Coxiella
MNLHEYQSKHLLKKYNIPVPASEVVFNPDAAVDAAAKIGGDRWVVKAQVHAGGRGKAGGVRLVKNKEELKSAVKALLGTRLVTYQTDERGQPVNQILVEQTSDIARELYLGAVIDRASQRIVFMASTEGGVEIEKVAEKSPEKILKVTVDPAIGLQPFQCRQLFFGLGLQDLKQMRSFTDIVMGLYRLFTERDLSLLEINPLVITGSGELICLDAKINIDDSALYRQSELREMRDTTQEDEHETMAQQWELNYIKLDGNIGCMVNGAGLAMATMDLIKLSGGDPANFLDVGGSATKERVTEAFKIIASDKNVKGILVNIFGGIVRCDLIADGIISAVKEVGIDVPVVVRLEGNNAQLGAKKLADSGMNIIAAKGFADAAEQIVKQVGVIA
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
B6J8N7
Q8NGP8
OR5M1_HUMAN
Olfactory receptor OR11-208
Homo
MFSPNHTIVTEFILLGLTDDPVLEKILFGVFLAIYLITLAGNLCMILLIRTNSHLQTPMYFFLGHLSFVDICYSSNVTPNMLHNFLSEQKTISYAGCFTQCLLFIALVITEFYILASMALDRYVAICSPLHYSSRMSKNICVCLVTIPYMYGFLSGFSQSLLTFHLSFCGSLEINHFYCADPPLIMLACSDTRVKKMAMFVVAGFNLSSSLFIILLSYLFIFAAIFRIRSAEGRHKAFSTCASHLTIVTLFYGTLFCMYVRPPSEKSVEESKITAVFYTFLSPMLNPLIYSLRNTDVILAMQQMIRGKSFHKIAV
Odorant receptor.
Q8NGP8
Q8XHH1
LGT2_CLOPE
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase 2
Clostridium
MRIVLGEIFGLKIYSYGFMIGLGIICATLLFLKRGTQRGYNEDKLFNATILTVISGILGGKILYIITEWKTVMQDPSLIFRDFGNGFVIYGAIIGGALGIALCSLKNKWNVLELADLVVPGLALAQGFGRIGCLLAGCCYGAETTSSIGIIFPADSLAPAGVPLYPTQIFSSIFDFALGLFLLWYGNKNKEKGKTMSMYMIIYSIGRFFVEFLRNDPRGSVGLLSTSQFISIFILIGGILLYNINKLKGRKETGEK
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Q8XHH1
Q6YW50
CKX7_ORYSJ
Cytokinin oxidase 7
Oryza sativa
MAARCSIAFMIMASCLSVVVSGGLPGDLFALSVASKLRVDRNSTARASSDFGRIVAAAPEAVLHPATPAEIAELVRFSASSPSPFPVAPRGQGHSARGQSLAPGGVVVDMRALASRRGRVNVSAGAAPYVDAGGEQLWADVLRATLEHGLAPRVWTDYLRITVAGTLSNAGIGGQAFRHGPQIANVLELDVITGTGDMVTCSRDKDSDLFFAVLGGLGQFGIITRARIGLMPAPKRVRWVRLAYSDVATFTKDQELLISKRASEAGFDYVEGQVQLNRTLTEGPKSTPFFSSSDIGRLAGLASKSVSGVIYVIEGTMYYNESTSTTMDQKLESILGQLSFEEGFVFTKDVRYVQFLDRVREEERVLRSIGMWDVPHPWLNLFVPRSRILDFDAGVFKGVFAGANPVGVILMYPMNTNMWDDCMMAVASDDDVFYAVGLLRSAAVIGDVERLEKENEAVLAFCHNEDIGCKQYLPYYTSQDGWQRHFGAKWSRVADLKAKYDPHRILSPGQRIFSSPASMVVVSM
Catalyzes the oxidation of cytokinins, a family of N(6)-substituted adenine derivatives that are plant hormones, where the substituent is an isopentenyl group.
Q6YW50
Q8I7M8
CDK17_CAEEL
PCTAIRE-motif protein kinase
Caenorhabditis
MTAYSPADSNAEARLLSGGSDPISDTENLLDLAYEVGTSSSDNTRYDRESENDEEEIGVGWEDTTSSSLNKRMCKSATFHDFCDDSEYSRRPVTTLHEEDFDEEEEDEFEDASDRRNLDEDDVEYEDEDDEDDIVVEEEEITPEDIEHSPTGVTTQTTPPSNNTSKSKKKKKRKSDEEDGLRKMKKSSTFASFLNMFVSRRRSGRDSGERLMSRSTCMLRPSISLSVVQESMILGSDGESVEVSPCTSDQTPTGVPPRYIVNVKMRQKTARKWSEEEIQKRLSLPADLRLPVAVVDKLNRTPTLDQPLTRKNRRASLSEIGFGKLETYEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQEEGAPCTAIREVSLLRNLRHANVVTLHDIIHTDRLLTLVFEYVDRDLKQYMDSCNNAMQMNNIRLFLYQLLRGLAYCHQRRVLHRDLKPQNLLITAKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILFEMIAGRALFPGGTPTEQLGLIFRTLGSPRPDRHPTICEKPTFYPYANRHYNPDPLCRQIPRIDAHGFELLMKFLQYEGKDRVSAAEAVKHPFLRTIAVKCCHLRDEQSVLEADGIHIERELLASDHHHSSRRHHRGTLVKDKYRMHSSHHT
Sufficient for synaptic vesicle trafficking in the DA9 motor neuron.
Q8I7M8
P08481
IPSG_PANLE
Double-headed protease inhibitor, submandibular gland
Panthera
ASPPEVNCSQYNRKGSGIACSKQLKPICGIDHKTYSNECMFCLLNQNKQFQIRKLYDDKCQIECTNYSAICTMEYFPLCGSDGKVYSNKCSFCNEVVKRRGTLFLAKYGQCK
This inhibitor is composed of two homologous actively inhibiting halves: one which inhibits trypsin, the other which inhibits elastase.
P08481
A5WCC8
CRCB_PSYWF
Putative fluoride ion transporter CrcB
Psychrobacter
MQWIAIGMGAAFGACLRALLGRLNPLHAWIPLGTLGANVLGGLLIGMAMVVFMKAGQLWHPNVKLFVMTGFLGGLTTFSTFSSEVFALLNSGKVMAGLVLIAVHVLLTLTATAMGYYLTRLCF
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
A5WCC8
Q9CLG7
RMUC_PASMU
DNA recombination protein RmuC homolog
Pasteurella
MQQDLNKTIEDFNQLLSKFEAVQQAKNQLEQHVVKYQTTAEGLQVRLIERDDKLAYLQKELDEEQARHNDIAEKITALKERFGIASAQAESLAKQLEHSQANFTRKEQENQELMAKLTTLSQELTELKTTLSEKEKHFAEQQQHIEQSKQQLSTEFQNLANRILDEKSRSFSQSNQTALDSLLKPFREQIEGFQKRVNEIHSESVKGNAGLEAEIKKVLEIGLNMSQQADNLTSALKGEKKTLGNWGEVQLERALQLAGLLEGEHYSAQAHLKDGEGKHNYPDFVLNLPDNKHLIIDSKMSLVAYESAVNAEDDLKRQNKLREHIKAIKNHIDDLSRKDYSNLIGMRSPNFVLMFIAVEPAYIEAMKMDPTLFNYGYEKNVILVSHTTLMPILRTVANLWRIERGNAEAKEISARAGDIYNQICVIAERLGKLGNTLSSASSHYNSTVTALVGQQGLVGKVERFKDLSAKANKTMPNVELLHHAVESERLDVIKADTPEAQPQKDNTAQ
Involved in DNA recombination.
Q9CLG7
A6W0S1
YCIB_MARMS
Inner membrane-spanning protein YciB
Marinomonas
MKILFDFLPIVIFFVVYKMTGNIIIATAILIPATIIQVGFTWFKNRTIEKMHLVSLALVVLLGGATVLLGDGDFIKWKPTIVNGLFAIAFLGSQFIGDKNIIQRMMGDKLDLPFKVWRTLNLAWVGFFIVSGVTNLYVAFSYSEEIWVDFKLFGLLGMTIVFIILQGIYLSSHLQNKE
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
A6W0S1
A4W3W3
ILVD_STRS2
Dihydroxy-acid dehydratase
Streptococcus
MTDTNKLKDFRHRSSVYDSMVKSPNRAMLRATGMTDDSFEKPIVGVISTWAENTPCNIHLHDFGKLAKEGVKEAGAWPVQYGTITVADGIAMGTPGMRFSLTSRDIIADSIEAAMGGHNVDAFVAIGGCDKNMPGSMIAIANMDIPAVFAYGGTIAPGNLNGKDIDLVSVFEGIGKWNNGDLTAEEVRQIECNACPGPGGCGGMYTANTMATAIEVMGMSIPGSSSHPAESPEKKADIEEAGRAVVRMLELGIKPSDIMTREAFEDAITVTMALGGSTNATLHLLAIAHAANVDLTLEDFNDFQERVPHLADLKPSGKYVFQDLYNVGGVPAVMKYLLKNGFLHGDRITCTGKTVAENLKNFADLTPGQDVIMPLENPKRADGPLIILKGNLAPEGAVAKVSGVKVRNHTGPAKVFDSEEEAIEAVLTDEIVDGDVVVVRYVGPKGGPGMPEMLSLSSMIVGKGQGDKVALLTDGRFSGGTYGLVVGHIAPEAQDGGPIAYLRTGDLVTVDQDTKEITMHVSDQEIEERKKTTVIPPLYSRGVLGKYAHTVSSASKGAVTDFWRPERTGKK
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
A4W3W3
Q1LSP8
EPMA_BAUCH
EF-P-lysine lysyltransferase
Candidatus Baumannia
MNKLISWKPRASIHNLFIRAKIINNIRIFFINRGLLEVETPVMSHTTVPDIYLFPFQTNLYFLEKVPEKGVPMYLITSPEYHMKRLLAAGSGPIFQICHSFRNQEYGNYHNPEFTLLEWYRPYYNMVDIMDEVNIFLQTIIHCDSAEMLSYQQVFRLHVGIDPLLAELDELNQVLVKFNLSSTISLYNDRDKLLDFLFLMLVRPHLGNNKPVFIYNFPASQSLLAELNSDDHRVAERFEVYFHGIELANGSRELTDADLQRERFMQENNKQVAMNRPPRLIDEQLLAALECGLPSCSGVALGIDRLLMLTLKAKHISEVMAFSVTDA
With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P.
Q1LSP8
A9AAH5
RF1_METM6
Translation termination factor aRF1
Methanococcus
MSGNSSTDMYLFKKSLKELKGKKGKGTELISVYVPAGRRLSDISQYLRQELSQSSNIKSKTTMKNVQSAIEVILQRLKLLKEPLEMGVIIFAGMIPRGGPGTEKMEVYVLEPPEPVKTFVYRCDSLFYTDPLEDFIQDTEVYGVILVDRNEATIGTVKGKTITVLKKLTSGVPGKFKAGGQSARRLERLIDDAAHQFMVRIGEYATESFMPILEEKKLKGLLLGGPGNTKNEFAEKDYLHHELKKKIIDTFDLCYTEEFGIRELLDKASDLLRDLDLMKEKNLIQRFFKELIKDDGGLSAYGEAQVMKYLEMGAIDTLIVTEDIGITRVTIKCNNCDYTQEVNVKTNEMFKFEEQLKTKACPTCGGAMYIDEEKDIIEHLSDLCNVHNTDIIVVSTDTEEGSQISRAFKGMAAILRYKL
Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
A9AAH5
B4TUM9
AAS_SALSV
Long-chain-fatty-acid--[acyl-carrier-protein] ligase
Salmonella
MLFGFFRNLFRVLYRVRVTGDVRALQGNRVLITPNHVSFIDGMLLALFLPVRPVFAVYTSISQQWYMRWLTPLIDFVPLDPTKPMSIKHLVRLVEQGRPVVIFPEGRISVTGSLMKIYDGAGFVAAKSGATVIPLRIDGAELTPFSRLKGLVKRRLFPRIQLHILPPTQIPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQYRYGAGKNCIEDINFTPDTYRKLLTKKLFVGRILEKYSVEGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVYLEDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPYDFYRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIENGGRLQLKGPNIMNGYLRVEKPGVLEVPSAENARGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTTDSELTREKLQHYAREHGIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQHHE
Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1.
B4TUM9
Q3U0B3
DHR11_MOUSE
Short-chain dehydrogenase/reductase family 24C member 1
Mus
MTRAGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGMARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNIDDGHIININSMCGHRVPPQSVIHFYSATKYAVTALTEGLRQELLEAQTHIRATCISPGLVETQFAFKLHDKDPGEAAATYEHIKCLRPEDVAEAVIYVLSTPPHVQVGDIQMRPTEQVT
Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.
Q3U0B3
A9WSU7
RL14_RENSM
50S ribosomal protein L14
Renibacterium
MIQQESRLKVADNTGAKEILAIRVLGGSGRRYAGIGDVIVATVKDAIPGGNVKKGDVVKAVIVRTKKERRRADGSYIKFDENAAVILKNDGDPRGTRIFGPVGRELRDKKFMKIISLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
A9WSU7
P11053
FERH_NOSS1
Ferredoxin, heterocyst
Nostoc
MASYQVRLINKKQDIDTTIEIDEETTILDGAEENGIELPFSCHSGSCSSCVGKVVEGEVDQSDQIFLDDEQMGKGFALLCVTYPRSNCTIKTHQEPYLA
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. Donates electrons to the nitrogenase.
P11053
Q2K6G8
TYSY_RHIEC
Thymidylate synthase
Rhizobium
MQQYLDLLAHVMEKGSDRGDRTGTGTRSVFGYQMRFDLGEGFPVLTTKKLHLRSIVHELLWFLKGETNIRYLKENGVSIWDEWADENGDLGPVYGAQWRSWPAPDGGHIDQIANLVKGIVNNPNSRRHIVSAWNPAEVDQMALPPCHCLFQFYVADGKLSCQLYQRSADVFLGVPFNIASYALLTMMVAQVTGLKGGDFVHTLGDAHLYHNHFDQAKLQLTRRPKPLPFMRINPEVKDIFGFTFDDFELIGYEADASIKAPIAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q2K6G8
O04351
OFP2_ARATH
Ovate family protein 2
Arabidopsis
MGNYKFRISEMLPNAWFHKLKDVTKHSKPKNKASSSSSNTCSKKKPSSDSLPQHSYFSNSLVANNPPHHNSPRNSLHTKKMSKRKTLYKPSLKPLTPPPLLVSASFNKSKINDQDSSYSLFPAIETSPESFVYSFYEEDDDDEFVEFSNFKINTKNKAFTKQKVKVIDSVEKACTASKPIKKPQKSHLSVKISRDEDDNEYKAEKKYQRQVSSGRKPSAGINLKRVNSPRIQLSGTRRSTSRRSESKQDVLESFAVMKRSVDPKKDFRESMIEMIEENNIRASKDLEDLLACYLTLNPKEYHDLIIHVFEQIWLQLTKTK
Transcriptional repressor that regulates multiple aspects of plant growth and development through the regulation of BEL1-LIKE (BLH) and KNOX TALE (KNAT) homeodomain transcription factors.
O04351
A7NLW9
PYRD_ROSCS
Dihydroorotate oxidase
Roseiflexus
MLYHLIRPLLFRLDAERAHDVVTAMFRATSRMPLLPRLISALYAWDDPALMVEWAGLRFASPLGVAAGFDKRADLVDALALLGFSHVEVGTVTPRPQPGNPGPRLFRLPEDMALINRLGFNSHGMVAVAKALRARRSRRVIVGVNIGKNRDTPLERAVEDYAATFVALAPLADYVAVNISSPNTPGLRRLHERAALEELLRELMRLNHGLLYPRPIALKISPDETLDQIEEVVRAGCEAGVAAFIATNTTLAREGLRSRLANETGGLSGRPLAPRARQVIRAIYRLTRGTPPVIGVGGVLTADDAYAHIRAGARLVQLYTGMVYAGPAIAREIKRGLAQLLRRDGFVSVTQATGVDAEWEGAIRQRG
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
A7NLW9
Q7W006
PURT_BORPE
Phosphoribosylglycinamide formyltransferase 2
Bordetella
MSTFPAPVLGTPLSPTATRVMLLGAGELGKEVVIALQRLGVEVIAVDRYADAPGHQVAHRAHVVSMTDPQALRQVIEQERPHVVVPEIEAIATDLLVALEDEGAVHVTPTARAAHLTMNREGIRRLAAETLGLPTSPYRFVDTEQALREAIDGGIGYPCVIKPVMSSSGKGQSIIRSADDIAAAWRYAQEGGRVGAGRVIVEGFIEFDYEITLLTVRARGADGQIVTQFCEPIGHRQVDGDYVESWQPHPMSPVALQRSREIALAVTGDLGGLGIFGVELFVAGDQVWFSEVSPRPHDTGMVTLISQVQNEFELHARALLGLPVDTRLRQPGASSVIYGGVDARGVAFEGVAQALAEPGTDIRLFGKPESYAKRRMGVGLAVADDVDQARAKAARVSQAVRVRA
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
Q7W006
A4J2F8
GCSPA_DESRM
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Desulforamulus
MKFIPHTDEERRQMLKHLAVENTDQLFKDIPSELRLNRDLAVEGGLSEMELQSHMNSLAGLNTGVDQTICFLGAGAYDHYIPSAVKHILSRSEFYTAYTPYQPEISQGVLQSIFEYQSMICLLTGMDAANASMYDGASALAEAALMACAVTRRDKVLVASTLHPEYREVVKTYLHGPGIEISEIAYQEGLSQLADIDQKLDKKTAAVLVQYPNFFGCIEDLGKIAEQAHAKGALLVVCVDPIALGILKSPGQCGADIVVGEGQSLGIPLSYGGPYLGFMACKDKYLRKMPGRIVGQTVDVEGRRGYVLTLQAREQHIRRDKATSNICSNQALCALAATVYLSLVGRQGFKQVAELCLQKTAYAKELLAALPGYQLPWQTPVFKEFVLKTKEAPEVINRELLKENILGGLDLGGYYPELAGHMLFCVTEKRSRREIELLAARLGAIS
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
A4J2F8
Q18919
RCORB_CAEEL
Suppressor of presenilin 1
Caenorhabditis
MDLYDDDGESAQSEKVDVPSEESTIAGPETDIPAETIEENVPEVEENTLLEEDSLVDVDSPRPSQQRSKPSKSKRKRKRSSSGESSAAEPEIDAGAKVKGPLSNTNKEINVGTEFQAKIADLNLNDKACNEDRDDQDELIWNTPETIDDEKLEAFIRESSDRYLIPIDRALYILTINNFNFDSAIAEVARRNELKDVWTDQEITLFENCYQIFGKNFSQIRSALCHRSLQSIVQFYYESKKRVKYLNFVNSKCDDSSSSEETETPSPYPEAIFESMCDNCGEKAENMQINNAMNRPECRACLIYFNQTGVPRPTSLRLVLAERIRNQVSCPDNMKEYMKDFDKLSAQATGSTFQKRIIVKDQCVEYIIDVDKIPSSSCTENGNVGETSSPSAQKTEIQSESDGSGPLIWRHKKTVCMEEIEVLADDSRRKMFEACQHGSKVDIKLVASWKNDMTNLRKRVEQTYYDPDLNPTYLFSHDRVHYSQDWTQLERSQVIRCFNMYGAHFEHIADVIGTKTPDQVYQFYLENQKAIDAADEEFLADMKNPERLADMEEEEDSI
Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1 . Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones . Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation .
Q18919
B5XW51
RF1_KLEP3
Peptide chain release factor 1
Klebsiella
MKSSIVAKLEALYERHEEVQALLGDAATIADQDKFRALSREYAQLSDVARCYTDWRQVQEDIETAQMMLDDPEMREMAQEELRDAKEKGDQLEQQLQVLLLPKDPDDERNAFVEVRAGTGGDEAALFAGDLFRMYSRYAESRRWQVEILSANEGEHGGFKEVIAKFSGDGVYGRLKFESGGHRVQRVPATESQGRIHTSACTVAVMPELPEAEMPDINPADLRIDTFRSSGAGGQHVNTTDSAIRITHLPTGIVVECQDERSQHKNKAKALSVLGARIRAAEVAKRQQAEASTRRNLLGSGDRSDRNRTYNFPQGRVTDHRINLTLYRLDETMEGKLDMLIEPIVQEYQADQLAALSEQE
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
B5XW51
Q8XJ55
DAPB_CLOPE
4-hydroxy-tetrahydrodipicolinate reductase
Clostridium
MVKVILNGCSGKMGSVISNLAETKFPNVEIVAGIDNNTNAQRSYPIFAKPEDCNISYDVLLDFSRADALKSLVQFSKKTKKPLILCSTGYTAEDLKFIEESSKEIPLFRSANMSIGINLVNNLLKKVAPVLYENFDIELVERHHNQKVDAPSGTALLLAHTIQDSLNEETKLLYGREGIAKREKNEICVNTVRGGGIIGDHEVIFAGDGEVIEINHKAISRDVFAIGALKACEYMADKTKAGKYSMDDVLQLNF
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Q8XJ55
P74977
HSTB_YEREN
Y-STB
Yersinia
MKKIILALVLMLFSFCTLGQETASMHLDDTLSAPIAAEINRKACDTQTPSPSEENDDWCCEVCCNPACAGC
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis.
P74977
B0TJ76
RIMM_SHEHH
Ribosome maturation factor RimM
Shewanella
MSSKQEPVILGKLGSSFGIKGWLKITTYTDSVEGIFDYSPWLIKEQGEWREVKVAQWRFQGKAVVACLEGVTTRDEAQALTNCEIAVPAEQMQDLPEDEFYWRDLIGCEVINTKGYNMGTVQEIVETGSNDVLLVKANAKDGFGKAERMIPFVTDQFIQKVDLAAKQILVDWDPDF
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
B0TJ76
P39982
HHY1_YEAST
Hypersensitivity to hygromycin-B protein 1
Saccharomyces
MSLSFLLFSPFLPPCFSSISICLSVLSTVSFFFAFTIPHYVLRCGSVDEWHIHSSAEDFRTQRCVCAVKLSASLLGCLLACASWSLLLEVSRIKWHVGTAYS
Involved in vacuolar trafficking.
P39982
Q9BY66
KDM5D_HUMAN
[histone H3]-trimethyl-L-lysine(4) demethylase 5D
Homo
MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVIEEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHPFDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYGPGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTMQLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPKCILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKMLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEMFIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESFDTWANKVRVALEVEDGRKRSFEELRALESEARERRFPNSELLQRLKNCLSEVEACIAQVLGLVSGQVARMDTPQLTLTELRVLLEQMGSLPCAMHQIGDVKDVLEQVEAYQAEAREALATLPSSPGLLRSLLERGQQLGVEVPEAHQLQQQVEQAQWLDEVKQALAPSAHRGSLVIMQGLLVMGAKIASSPSVDKARAELQELLTIAERWEEKAHFCLEARQKHPPATLEAIIRETENIPVHLPNIQALKEALTKAQAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKALGLYQCDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLAPSLMASSPTSICVCGQVPAGVGVLQCDLCQDWFHGQCVSVPHLLTSPKPSLTSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAIGWQDRARKALASEDVTALLRQLAELRQQLQAKPRPEEASVYTSATACDPIREGSGNNISKVQGLLENGDSVTSPENMAPGKGSDLELLSSLLPQLTGPVLELPEAIRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLDRIRTLLELEKFEHQGSRTRSRALERRRRRQKVDQGRNVENLVQQELQSKRARSSGIMSQVGREEEHYQEKADRENMFLTPSTDHSPFLKGNQNSLQHKDSGSSAACPSLMPLLQLSYSDEQQL
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.
Q9BY66
Q9LFP0
APT5_ARATH
Adenine phosphoribosyltransferase 5
Arabidopsis
MFAAENGLKGDPRLEAISAAIRVVPNFPKKGIMFQDITTLLLDHKAFKHTIDIFVDRYKDMQISVVAGVEARGFLFGPSIALAIGAKFIPLRKPGKLPGKVISESYELEYGHDRLEMHVGAVEPRERVIIIDDLVATGGTLSAAMSLLESQGAEVVECACVIGLPEVKGQHKLKGKPLYVLVEPSGLDEFC
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. May contribute to the recycling of adenine into adenylate nucleotides and the inactivation of cytokinins by phosphoribosylation. Possesses low activity toward adenine, but can efficiently convert cytokinins from free bases (active form) to the corresponding nucleotides (inactive form).
Q9LFP0
Q941T1
P5CS2_ORYSJ
Glutamyl-gamma-semialdehyde dehydrogenase
Oryza sativa
MGRGGIGGAGLVAAVAKADVENTDSTRGFVKDVKRIIIKVGTAVVTGPNGRLAMGRLGALCEQVKQLNFEGYEVILVTSGAVGVGRQRLKYRKLVNSSFADLQNPQMDMDGKACAAVGQSVLMAIYDTLFSQLDVTSSQLLVTDRDFMDPSFGNQLRETVNSLLDLKVIPVFNENDAISTRRQPYEDSSGIFWDNDSLARLLAQELKADLLIMLSDVEGLYSGPPSDPQSKIIHTYVHEQHGKLISFGEKSRVGRGGMQAKVAAAFTASSKGIPVVIASGFAIDSIIKVMRGEKIGTLFHREANQWGCSKEATAREMAVAARDCSRHLQKLSSEERKKILLDIADALEANEDLITSENQADLDLAQDIGYDKSLVARMTIKPGKIKSLAGSIREIADMEDPISHTLKRTEVAKDLVFEKTYCPLGVLLIIFESRPDALVQIASLAIRSGNGLLLKGGKEAMRSNTILHKVITGAIPDVVGKKLIGLVKNKDEIADLLKLDDVIDLVIPRGSNKLVSQIKAATKIPVLGHADGICHVYIDKSADMDMAKRIVLDAKVDYPAACNAMETLLVHKDLNRTEGLDDLLVELEKEGVVIYGGPVAHDTLKLPKVDSFHHEYNSMACTLEFVDDVQSAIDHINRYGSAHTDCIITTDGKAAETFLQQVDSAAVFHNASTRFCDGARFGLGAEVGISTGRIHARGPVGVDGLLTTRCILRGSGQVVNGDKGVVYTHRELPLQ
P5CS plays a key role in proline biosynthesis, leading to osmoregulation in plants. Involved in abiotic stress tolerance.
Q941T1
B2TKE1
DEOB_CLOBB
Phosphodeoxyribomutase
Clostridium
MKKYNRIFTIVIDSLGIGGMPDSMEYGDKGVDTLGHIAESVEKFNIPNLEKLGISNLHPIKHVKAAEKPLAHYMKMKEASVGKDTMTGHWEMMGLHITKPFQTFTDTGFPQELLDELTKRTGHNIVGNKSASGTEILDELGEHQMKTGDMIVYTSADSVLQICGHEETFGLDELYRCCEIARELTLKDEWKVGRVIARPYLGSKKGEFKRTSNRHDYALKPYGSTALNTLKDNGFDVISVGKISDIFDGEGITESNKSKSSVHGMEQTLEIMDKDFKGLCFVNLVDFDALWGHRRNPVGYAEEIEKFDIKLGKVLEKLKEDDLLIITADHGNDPTYVGSDHTREFVPFIAYSPSMKENGLMDTVDSFATIGATIADNFELKMPENTIGKSVLEKLV
Phosphotransfer between the C1 and C5 carbon atoms of pentose.
B2TKE1
D9RZP4
ECFT_THEOJ
Energy-coupling factor transporter transmembrane protein EcfT
Thermosediminibacter
MREITIGQYIPGNSVIHRLDPRTKILITTAFMVLLFVIDDFTGYAFPAVFIIAVSILSGISLKYMMRGLRPLVIIIVLTFVLNLFMIKGRVIYEIGPLDITYEGLYQGTFMVLRLIMLIVGTSLLTLTTSPIALTDGIESLLKPFRRVGVPAHELAMMMTIALRFIPTLMEETDKIMKAQMARGADFASGNVVQRARSLVPLLVPLFINAFRRADDLAMAMESRCYRGGENRTRMKQLRMTSADLAAFIATGLLAVGSIMSRFIW
Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
D9RZP4
Q1LT56
DEF_BAUCH
Polypeptide deformylase
Candidatus Baumannia
MSLLPILYYPDHRLRQISKPVNKINNSIYRIVYDMFDTMYHKNGIGLAAPQVNINLNIIVIDVSENKEQRLVLINPELLAKSGETGIHEGCLSIPEQHGFVPRAKNIKVRALDLNGNSFNLETNDLQAICIQHEMDHLVGKLFIDYLSPLKRQRLLKKMKQLIRNLD
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Q1LT56
B0JPS9
QUEF_MICAN
PreQ(0) reductase
Microcystis
MVQSSEKIEVKYGEREIAEGTLITFPNPRPGRNYDIQITLPEYTCKCPFSGYPDFATIYLSYVPDQKVMELKAIKLYINSYRDRYISHEEAINQILDDLVAACEPLQMKVKGDFHPRGNVHTVVEVMYKKE
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
B0JPS9
A0A0E3D8N4
PEND_PENCR
Penitrem biosynthesis cluster protein D
Penicillium
MTNSLLNNGDMVQGVELPDADQQFWWDSLAPILSRMLQCSKYSVQSQANILSFFKDFIVPSYGPRPSIDGEFFWKSYVTYNHTPGQVSFNFHKNKCTVRLSNVPTAPLAGTASDPFNQKGVVQTIKHIQKALPGMDMTIFDYFSEAFLVADEDTVGLDARKPVPQYNQLVVASMLGYDFEPVPRVKVYFNPRWKALQMNIENHDLIWTAINNLGSPIKSYKRTLDLLQECGNPRQPGGWIFQPEFISFDMGENMSNTARLKLYGFTTKTCWSHIESIYTLDRRLDDAETQRGLAVLKRLWHLALSIPEDHDENQDLPPCPHLTAGVIYNYELRENSAKPEAKIYIPVRFYGSGDGKVIEGLVDFFKSEGWDELATSYQRDFVSVFSTPDGKMVGEHHDISFSYKNDHPYVTAYYRPELIRPMERHIV
Indole diterpene prenyltransferase; part of the gene cluster that mediates the biosynthesis of the indole diterpenes penitrems . The geranylgeranyl diphosphate (GGPP) synthase penG catalyzes the first step in penitrem biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) (Probable). Condensation of indole-3-glycerol phosphate with GGPP by the prenyl transferase penC then forms 3-geranylgeranylindole (3-GGI) (Probable). Epoxidation by the FAD-dependent monooxygenase penM leads to a epoxidized-GGI that is substrate of the terpene cyclase penB for cyclization to yield paspaline (Probable). Paspaline is subsequently converted to 13-desoxypaxilline by the cytochrome P450 monooxygenase penP, the latter being then converted to paxilline by the cytochrome P450 monooxygenase penQ . Paxilline is converted to beta-paxitriol via C-10 ketoreduction by the short-chain dehydrogenase PC-15 which can be monoprenylated at the C-20 by the indole diterpene prenyltransferase penD (Probable). A two-step elimination (acetylation and elimination) process performed by the O-acetyltransferase PC-16 and the P.simplicissimum ptmI-ortholog not yet identified in P.crustosum, leads to the production of the prenylated form of penijanthine (Probable). The FAD-linked oxidoreductase ptmO then converts the prenylated form of penijanthine into PC-M5 which is in turn transformed into PC-M4 by the aromatic dimethylallyltransferase PC-22 (Probable). A series of oxidation steps involving 4 cytochrome P450 monooxygenases (PC-21, PC-05, PC-23, PC-20) and a FAD-dependent monooxygenase (PC-14) are required for the transformation of PC-M4 to penitrems A and E. Synthesis of these final products is proposed to proceed via penitrems D and C (PC-21, PC-05, PC-14) and penitrems B and F (PC-21, PC-05, PC-14, PC-23) (Probable).
A0A0E3D8N4
Q9I9M5
FZD1_XENLA
Frizzled-1
Xenopus
MKHSHLLQRCSAQLCTRGSSLILSLLLSVCLSVEGQYNGEKGISIPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELKFFLCSIYAPVCTVLEQALPPCRSLCDRARQGCEALMNKFGFQWPESLRCEKFPINGAGELCVGQNTTESGTPTPAVPETWTSNSRTYYRDKFMCPRALKVPAYVNYHFLGEKDCGAPCEVGKVHGLMYFAPEELNFARIWIGIWSVLCCASTLFTVLTYLVDMKRFSYPERPIIFLSGCYTMVAIAYIAGFLLEDKVVCNERFAEDGYKTVAQGTKKEGCTFLFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAIKTITILAVGQVDGDTLSGVCFVGINNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGIFSVLYTVPATIVIACYFYEQAFREQWEKSWISQSCKTYAIPCPSTGHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYTRLTNSKQGETTV
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway . The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes . A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
Q9I9M5
Q7NYR7
SYM_CHRVO
Methionyl-tRNA synthetase
Chromobacterium
MIRMTKRKILVTSALPYANAGLHLGHMLEQIQTDIWVRFQKMRGHECYYVCADDTHGAPIMLAAEKRGITPEQLVNEVRELHVADSQGFLIGHDNYYSTNSPENKALAEQVYLALKADDKIACRTIEQLFDPEKQMFLPDRFVKGECPKCSAKDQYGDNCEVCGATYAPTELKNPYSAVSGAKPVLKTSEHFFFRLGECADFLKAWTSGASRRADGAVQPHLQPESLNKMNEWIGGGLQDWDISRDAPYFGFEIPGAPGKYFYVWLDAPIGYMASFKNLCERLNLNFDEWFAKDSQTEMYHFIGKDILYFHALFWPAMLNYSGLRAPTGVFAHGFLTVDGQKMSKSRGTFIQAKSYLDCGLNPEWMRYYIAAKLNGRIEDIDLNLNDFVARVNSDLVGKFVNIASRSAGFIAKRFDGMLAAQVSDGEILAKLQAAAEELAAAYEAREYAKALRDVMALADIVNGYVDANKPWELAKQEGQDARLQDVCTVLVNAFRLLAIYLKPVLPKLAEGVEAFLDVAPLSWHDAETLLLGKKINAYQHLMQRIDPALIDKLIEANKQNMQAIQDAPAAAAHEPLAETIKIDDFAKVDLRVGKVLECNFVEGSDKLLQFKVDLGFETRNIFSGIRKAYQEPEKLVGRHVIVVANLAERKMRFGVSQGMIVCASGVDDSEGLFLLDVDAGVKPGMRVG
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Q7NYR7
D0ZCI3
PAGP_EDWTE
Lipid A acylation protein
Edwardsiella
MKTHNDILAALAALPLFLTGAAFAAEPGMLDTLRNNIVQTWEQPQHYDLYLPAITWHARFAYSQEKIDSYNERPWGAGFGQSRWDEKGNWHGLYLMAFKDSFNKWEPIGGYGWEATWRPLEGSDFHWGAGYTVGVTMRDNWRYIPIPVILPMASVGYGPLTLQMTYIPGTYDNGNVYFAWLRLQF
Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.
D0ZCI3
Q5M8N0
CNRP1_MOUSE
CB1 cannabinoid receptor-interacting protein 1
Mus
MGDLPGLVRLSIALRIQPNDGPVFFKVDGQRFGQNRTIKLLTGSSYKVEVKIKPTTLQVENISIGGVLVPLELKGKEPDGERVVYTGIYDTEGVAPTKSGERQPIQITMPFTDIGTFETVWQVKFYNYHKRDHCQWGSPFSVIEYECKPNETRSLMWVNKESFL
Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels.
Q5M8N0
B5BB76
SYE_SALPK
Glutamyl-tRNA synthetase
Salmonella
MKIKTRFAPSPTGYLHVGGARTALYSWLFARHHGGEFVLRIEDTDLERSTPEAIEAIMDGMNWLNLEWDEGPYFQTKRFDRYNAVIDEMLEAGTAYKCYCSKERLEQLREDQMAKGEKPRYDGRCRHSHEHHADDEPCVVRFANPQDGSVIFDDQIRGPIEFSNQELDDLIIRRTDGSPTYNFCVVVDDWDMEITHVIRGEDHINNTPRQINILKALNAPVPMYAHVSMINGDDGKKLSKRHGAVSVMQYRDDGYLPEALLNYLVRLGWSSGDQEIFTREEMIKLFSLGAVSKSASAFNTDKLLWLNHHYINTLAPEYVATHLQWHIEQENIDTRNGPQLAELVKLLGERCKTLKEMSQSCRYFYEDFSEFDADAAKKHLRPVARQPLEVVRDKLSAITDWSAENVHHAIQATADELEVGMGKVGMPLRVAVTGAGQSPALDVTVHAIGKTRSIERINKALGFIAERESQQ
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
B5BB76
A7NEI8
IF2_FRATF
Translation initiation factor IF-2
Francisella
MAEITVGQLAQQTNKEVDALLKQLKSFGIEKSSEKDTLTPTEMKTLLEKINSAKNTATRKKVTSVKLDGKHKINVSVKRKRRVAKKMEQQESTTLEQPQELETMVQEVSQQVDIVKEQDNIEQIVENKEAVKVQEQRQAEIAKPVIKDSGFKITAMPEIKIEEIVAEDDEGLAASDKQAKKKAAKKVFSEAVNTNTKYKCEEEEKKSKAKKAGGKGFKKANPRQLSQLAGDLESFDEFGAKKGKLKAPKVKKQEFTKPVENTVRTVEIHEGITVSELAQKMAVKGAEIVKVLFNMGVMATINQSLDQDTAILIVEEMGHKYTLHNENALEEAVTIVDRSSYKKISRAPVVTIMGHVDHGKTSLLDYIRQTRVVAGEAGGITQHIGAYSVKTDKGSITFLDTPGHEAFTSMRARGAKSTDIVILVVAADDGVMPQTEEAIQHAKAARVPIVVAVNKIDKPEADSDKVISELAQRNVIPESWGGDVMFVNVSAKTGEGVADLLEAVLLQSEVLELEAFAEGLAEGVVIESRLEKGRGPVATVLVQNGNLKQGDNILCGTEYGRVRAMHNDLGKKIKAAGPATPVEILGLSGVPAAGDEMVVIENEKKAKELAAQRSQKQKEAKIAQEQSLKLSNMFNNMGKEGEQQVLKIILKGDVQGSVEAIRESLLKLSTDEVKVDIIASGIGAITSSDVTLAVASTAVVIGFNVRADSAAKKLAETDGVEFRYYNIIYDLIDDVKKAMSGLLSPEMKEQIIGIAEVREVYRSSKFGSIAGCMVIEGVVKRTNPIRVLRNNVVIYEGTLESLKRFKDDASEVKKGLECGIGVKNYNDVREGDQIEVFEVIEVAKEL
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A7NEI8
P83216
HSP4_OCTVU
Sperm protamine P4
Octopus
RRRRRRRGHRGRRGRGGRRSRGRRRRAA
Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.
P83216
Q5HLI0
GPMA_STAEQ
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Staphylococcus
MPKLILCRHGQSEWNAKNLFTGWADVKLSKQGIEEAQSAGKKIYGNQIEIDIAFTSLLTRALETTQYILAGSDQQWIPVYKSWRLNERHYGGLQGLNKDDARKKWGEDQVHQWRRSYDVRPPRESEEQREAYLKNRRYQHIDHRMMPYCESLKDTLERVVPFWTDHISQHLLDDKTVLVSAHGNSIRALIKYLEGLSEEDIVGYEIKTGAPLVYELTDDLVVKDKYYL
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Q5HLI0
P01094
IPA3_YEAST
Saccharopepsin inhibitor
Saccharomyces
MNTDQQKVSEIFQSSKEKLQGDAKVVSDAFKKMASQDKDGKTTDADESEKHNYQEQYNKLKGAGHKKE
Specific and potent inhibitor for yeast aspartic protease A (yscA). The proteinase acts as a folding template stabilizing the helical conformation in the inhibitor, which results in the potent and specific blockage of the proteolytic activity.
P01094
Q749Y6
AROA_GEOSL
5-enolpyruvylshikimate-3-phosphate synthase
Geobacter
MVSLSSHPARALRGEIAVPGDKSISHRSIMLGSIARGVTTVSGFLRGEDNIATLDAFRAMGVQVHDDGETLRIEGKGLHGLTEAEDVIDCGNSGTSIRLLTGLMAAQRFYTVLTGDRYLRRRPMRRVVEPLSRMGACIHGRDNGEKAPLAIVGRPLTGIAYDSPVASAQVKSALMLAGLYADGATRVTEPHLSRDHSERMFRHFGARLETDAAGVTVYGGHELDGRDIVVPGDISSAAFFLVAALIVPGSELLIRGVGVNPTRTGILDILAAMGGSVELLDQREVSGEPVADLLVRSSALKGIEIGGDVVPRAIDEFPVICVAAALAEGTTVIRDARELRVKETDRIAAMAANLRAAGATITETADGMIIEGTGRLNGVTVESFGDHRIAMSMLVAGLAASGAITVSDTECIATSFPTFTALLDKVAVR
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Q749Y6
Q8Z9L4
CAIC_SALTI
Crotonobetaine/carnitine--CoA ligase
Salmonella
MDIVGGQNLRQMWDDLAGMYGDKTALIFESCEGIVRQFSYASLNEEINRTANLFYYLGIRKGDRVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLGEESAWILQNSQVSLLVTSAQFYPMYREIRQDNSTPLNHICLIGEQLPADDGVSHFSQLQARQSATLCYTPALSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQIALRDDDVYMTVMPAFHIDCQCTAAMPAFSAGSTFVLLEKYSARAFWDQVRKYQATVTECIPMMIRTLMVQPATPTDRQHHLREVMFYLNLSAQEKDAFTERFGVRLLTSYGMTETIVGIIGDRPGDKRRWPSIGRVGFSYEAEIRDDQNRPLPAGEIGEICIKGIPGKTIFKEYYMQPEATARALEPEGWLHTGDSGYQDEDGYFYFVDRRCNMIKRGGENVSCVELENIISAHPKIQDIVVVGIKDAIRDEAIKAFIVLNEGETLSEAEFFSFCENNMAKFKVPSFMEIRTDLPRNCSGKIIKKNLK
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
Q8Z9L4
Q5X703
LIPA_LEGPA
Sulfur insertion protein LipA
Legionella
MGKLIDIPIVVESGQKYKTSQGVTAIKDGIKSSGQDHERLPKPKWLRIVNHTTPAYSQVKEQVQKHRLATVCEEAKCPNISECWSHGTATIMLMGAVCTRACRFCSVDTGNPHGWLDAEEPENTAETVALMNLDYVVLTSVNRDDLPDGGANHYAKTIRAIKKRSPRTKVEALTPDFQGSERDVAVLLDSGVDVFAQNVETVERLTHPVRDNRAGYQQTLNVLAFAKKYRPDVLTKTSLMLGLGETDEEIIQTMDDLRTHHVDILTLGQYLQPTKNHLPIARYVTPETFSELRQIGLKKGFFEVASGPLVRSSYRADRVFKRDNLGLDV
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Q5X703
Q6D0F3
THIQ_PECAS
Thiamine import ATP-binding protein ThiQ
Pectobacterium
MIALEKLTYFYQHLPMRFDFHVKPGERIAILGPSGAGKSTLLNLVAGFLMADSGELRLNGESHRETSPAKRPVSILFQENNLFPHLTIGQNIALGLHPGLRLNAAQRATLQQIADRVGLTDLLDRLPSQVSGGQRQRAALARCLVRHQPILLLDEPFSALDPALRQEMLDLVESVCEERKFTLLMVSHNLDDAMRIAKRTVLIVDGQIYYDGPTQALQDGSADAAAILGISRSSSD
Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system.
Q6D0F3
P42698
DR111_ARATH
REQUIRED FOR SNC4-1D protein 2
Arabidopsis
MLGGLYGDLPPPTDDEKPSGNSSSVWSSSTKMAPPTLRKPPAFAPPQTILRPLNKPKPIVSAPYKPPPPSNSSQSVLIPANESAPSHQPALVGVTSSVIEEYDPARPNDYEEYKREKKRKATEAEMKREMDKRRQEDEERDKREREEREKERERDNSDPSRLNISGEEAWKRRAAMSGGGSGGKGRSSSPPGNVDGFSIGKSETSGLGVGAGGQMTAAQRMMAKMGWKQGQGLGKSEQGITTPLMAKKTDRRAGVIVNASENKSSSAEKKVVKSVNINGEPTRVLLLRNMVGPGQVDDELEDEVGGECGKYGTVTRVLIFEITEPNFPVHEAVRIFVQFSRPEETTKALVDLDGRYFGGRTVRATFYDEEKFSKNELAPVPGEIPGY
Seems to be involved in the resistance to UV light and chemical DNA-damaging agents . Regulates the splicing of the receptor-like kinase SNC4/LRKL-2.6 .
P42698
O27784
MER_METTH
Methylene-H(4)MPT reductase
Methanothermobacter
MKFGIEFVPNEPIEKIVKLVKLAEDVGFEYAWITDHYNNKNVYETLALIAEGTETIKLGPGVTNPYVRSPAITASAIATLDELSNGRATLGIGPGDKATFDALGIEWVKPVSTIRDAIAMMRTLLAGEKTESGAQLMGVKAVQEKIPIYMGAQGPMMLKTAGEISDGALINASNPKDFEAAVPLIKEGAESAGKSLSDIDVAAYTCCSIDEDSAAAANAAKIVVAFIAAGSPPPVFERHGLPADTGAKFGELLGKGDFGGAIGAVDDALMEAFSVVGTPDEFIPKIEALGEMGVTQYVAGSPIGPDKEKSIKLLGEVIASF
Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT.
O27784
Q8DVS3
Y394_STRMU
Nucleoid-associated protein SMU_394c
Streptococcus
MMNMQNMMKQAQKLQKQMEKKQSELASMTFVGKSAQDLVVATFTGNKKLVSIDFKEAVVDPDDRETLQDMTVQAINDALGQIEDATQKTMGAFAGKLPF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q8DVS3
P43318
PA2_RHONO
Phosphatidylcholine 2-acylhydrolase
Rhopilema
GLIKPGTLWCGMGNNAETYDQLGPFADVDSCK
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
P43318
P42072
CTLA4_RABIT
Cytotoxic T-lymphocyte-associated antigen 4
Oryctolagus
MARLGFQRQGTQLDLASRTWSCAALFSLLFLPVFSKALHVSQPAVVLASSRGVASFVCEYASSHKATEVRVTVLRQANSQMTEVCAMTYTVENELTFIDDSTCTGISHGNKVNLTIQGLSAMDTGLYICKVELMYPPPYYVGMGNGTQIYVIEPEPCPDSDFLLWILAAISSGLFFYSFLITAVSLSKMLKKRSPLTTGVYVKMPPTEPECEKQFQPYFIPIN
Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
P42072
P42481
EFTU_THIDL
Elongation factor Tu
Thiomonas
MAKSKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLSSKFGGEAKAYDQIDAAPEEKARGITINTAHVEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIIVFLNKCDMVDDAELLELVEMEVRELLSKYDFPGDDTPIIKGSAKLALEGDKGELGEGAILKLAEALDTYIPTPERAVDGAFLMPVEDVFSISGRGTVVTGRVERGIIKVGEEIEIVGLKPTLKTTCTGVEMFRKLLDQGQAGDNVGILLRGTKREEVERGQVLCKPGSIKPHTHFTAEVYVLSKDEGGRHTPFFNNYRPQFYFRTTDVTGAIELPKDKEMVMPGDNVSITVKLIAPIAMEEGLRFAIREGGRTVGAGVVAKIIE
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
P42481
Q8UE71
COBT_AGRFC
N(1)-alpha-phosphoribosyltransferase
Agrobacterium tumefaciens complex
MSMSGLPFDDFRALLRELPGPDTHALVAAKERNAQLTKPAGSLGRLEEIAMWLAAWSGRSPAVTRPLVAIFAGNHGVTRHGVTPYPTSVTQQMVENFAAGGAAINQICVANDLGLKIFDLALDYPTGDITCEPALSERDCAATMAFGMEAIAGGTDLLCVGEMGIGNTTIAAAINLALYGGTAEEWTGPGTGSEGEVMARKIAAVKAAVEFHKDHLSDPLEIMRRLGGREIAAIAGAILAARVQRIPVLIDGYVATAAAALLKAANSSALDHCLIGHVSGEPGHLAAVEKLGKTPLLALGMRLGEGTGAALAAGIVKAAAACHSGMATFEAAGVDTRISPRTEH
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Q8UE71
Q0H8X2
BI1_USTMA
Intron-encoded endonuclease bI1
Ustilago
MRLLKTHPILGLANSYLIDSPQPSNISYMWNFGSLLGVCLIIQILTGVFLAMHYTPSVDLAFISVEHIMRDVNYGWLIRYLHANTASFFFIFVYLHIGRGLYYGSYKSPRTLLWSIGVIILVLMMAIAFLGFNGQKYMCFYNIDITIIQYLSIPTLITPSTRLKPILDKHNIKPVLLFENLTNSETKKIAYQALKPFSGIYMIVNLITEKYYVGSAVTGNLYMRFHKHLFSFTGNKRVANAVNKYGLSEFAFLVLEIVPQKDKIDSTLLLNREDYYLETLKPEYNIAPLASNSLGWKHSEESLAKMRENYSEERRQQVANINKGKTLSEETRELIRKSALLRKSMSSETRMKCAVNVQPVTIINLDGTNIMNFVSIKEASIAISCNEKTIRRALNGNGIVKKNYIVKVIK
Mitochondrial DNA endonuclease involved in intron homing.
Q0H8X2
A3MKP1
ALLA_BURM7
Ureidoglycolatase
pseudomallei group
MKTLSIEPLTRAAFAPFGDVIETQGAKQIPINLGTTMRFHDLAKIDVADEGGRPLVNLFRGQPRTLPFEVTMLERHPLGSQAFVPLTDRPYIVVVAPAGDLDASKIRAFVTSGWQGVNYAKGVWHHPLIALGEVSDFIVVDRGGDGRNLNEQNLPESLWLTDDALLAVGA
Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source.
A3MKP1
B7KGG1
GPMI_GLOC7
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Gloeothece citriformis
MADAPIAPVVLVILDGWGYRQTTDYNAIAVANTPVMDSLWEAYPKTLIRTSGKDVGLPEGQMGNSEVGHLNIGAGRIVPQELVRITDAIEDGSIFQSPVLINLCDEVKGRGGKLHLIGLSSAGGVHSHLCHLLGLLDLAKLHSVSDVCVHAITDGRDTNPTEGVNVIEAIQAHIDKIGVGRISTVCGRYYAMDRDRRWDRVKKAYDLLTEDGEGDGRSASQILKDFYAQDITDEFILPTRVAPGAIEPGDGIIFYNFRPDRARQLCYAFTMPDFDGFERDLIQPLSFVTFTQYDPKLPVKVVFEPQSLTNILGEVIAKKGLRQFRTAETEKYPHVTYFFNGGLEQPFEGEDRELIQSPMVATYDKAPVMSAEAVTDTACAAIKKGIYSLVVMNYANPDMVGHTGNMEAAVQAIEAVDRCLGRLLGCINKMGGTVLITADHGNAEYMRDEEGNPWTAHTTNPVPFILVEGEKRKIPGHGANVVLRNDGRLADIAPTILDILQLPQPNNMTGKSLIEPAGFDVKTNRTPVRISL
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
B7KGG1
A5WG99
TTCA_PSYWF
tRNA 2-thiocytidine biosynthesis protein TtcA
Psychrobacter
MQTNFSQPQTFNPADITRNVIDNNQDDMVDSLDSDEEDLDLDLDLELSDEQEIAHKGVKSARFKKLQKKLRKQVSHAIRDFNMIEDGDVVMVCVSGGKDSYTLLDILLFLKRIAPINFDVVAVNLDQKQPGYPEEVLPNYLQQQGIPHYILEKDTYSVVKSVVPEGKTYCSACSRLRRGSLYGFAKQIGATKIALGHHRDDILATFFLNLFHGGSLKAMPPKLLSDDKQNVLIRPLAYVEEKDIIKYARYKEFPIIPCNLCGSQENLQRAMINDMLRQWDDAHPQRLASIFKAMQNVAPSQLADRELFDFESLTLQRDDSKRDFEGHNIQVGVANELAEIGLPTQPDIKPFESATAAKKIPTINPIID
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
A5WG99
Q06GK9
NDHI_PIPCE
NADH-plastoquinone oxidoreductase subunit I
Piper
MFPMITGFMNYGQQTVRAARYIGQSFAITLSHTNRLPVTIQYPYEKSITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDIRKKRLLNYSIDFGICIFCGNCVEYCPTNCLSMTEEYELSTYDRHELNYNQIALGRLPISVIEDYTIQTNNYELNSYKKMTDKPLDSEKITN
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
Q06GK9
B5XK69
OLHYD_STRPZ
Myosin cross-reactive antigen
Streptococcus
MYYTSGNYEAFATPRKPEGVDQKSAYIVGTGLAGLAAAVFLIRDGHMAGERIHLFEELPLAGGSLDGIEKPHLGFVTRGGREMENHFECMWDMYRSIPSLEIPGASYLDEFYWLDKDDPNSSNCRLIHKRGNRVDDDGQYTLGKQSKELIHLIMKTEESLGDQTIEEFFSEDFFKSNFWVYWATMFAFEKWHSAVEMRRYAMRFIHHIDGLPDFTSLKFNKYNQYDSMVKPIIAYLESHDVDIQFDTKVTDIQVEQTAGKKVAKTIHMTVSGEAKAIELTPDDLVFVTNGSITESSTYGSHHEVAKPTKALGGSWNLWENLAAQSDDFGHPKVFYQDLPAESWFVSATATIKHPAIEPYIERLTHRDLHDGKVNTGGIITITDSNWMMSFAIHRQPHFKEQKENETTVWIYGLYSNSEGNYVHKKIEECTGQEITEEWLYHLGVPVDKIKDLASQEYINTVPVYMPYITSYFMPRVKGDRPKVIPDGSVNLAFIGNFAESPSRDTVFTTEYSIRTAMEAVYSFLNGERGIPQGFNSAYDIRELLKAFYYLNDKKAIKDMDLPIPALIEKIGHKKIKDTFIEELLKDANLM
Catalyzes the hydration of oleate at its cis-9-double bond to yield 10-hydroxyoctadecanoate, and of linoleate at its cis-9- and cis-12-double bond to yield 10-hydroxy-12-octadecenoate and 10,13-dihydroxyoctadecanoate. Is not active on trans-double bonds and esterified fatty acids as substrate; is only active on cis-9- and/or cis-12-double bond of C16 and C18 fatty acids without any trans-configurations, producing 10-hydroxy and 10,13-dihydroxy derivatives. Appears to play a role in oleic acid detoxification and bacterial virulence.
B5XK69
Q4FMP0
THIG_PELUB
Thiazole synthase
Candidatus Pelagibacter
MVNDKLIIDKKKFNSRLIVGTGKYKSMAECAKAIKLSGAEIVTVAVRRVNISDKKKPLLMDYIDPKKITYLPNTAGCFNSEEALRTLRLAREIGGWKLVKLEVLGDKKNLFPDMIETLKSTEVLTREGFRVMVYCNDDPLMAKRLENVGACAIMPLAAPIGSGLGIQNTTNIKIIRSQTKLPLIIDAGLGQASDAAIAMELGCDGVLANTAIAKAKKPFQMALAFKNGVIAGRQSYLAGRIEKSIYGSASSPKTGII
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Q4FMP0
Q15363
TMED2_HUMAN
p24 family protein beta-1
Homo
MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.
Q15363
Q163V9
PURL_ROSDO
Phosphoribosylformylglycinamidine synthase subunit II
Roseobacter
MQEPAITPDLIASHGLSPDEYDRILNIVGRTPTFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVICGPGENAGVVDIGDGQAVVFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPIAAMNSLSFGEISHPKTRQLVNGVVAGVGGYGNCFGVPTVGGEVRFDPAYNGNCLVNAFAAGLADADKIFYSAASGVGMPVVYLGAKTGRDGVGGATMASAEFDDTIEEKRPTVQVGDPFTEKRLMEATLELMQTGAVISIQDMGAAGLTCSAVEMGDKGNLGVRLDLEKVPVREEAMTAYEMMLSESQERMLMVLRPELEQEAKAVFDKWDLDFAIVGETIAEDRFLIVHNGEVKADLPLKTLAGTAPEYDRPWVATPAADPLGDVPDVDPIDGLRALISSPNYASKDWVFTQYDTMVMADTVRIPGIGAGIVRVHGTDKALAFTSDVTPRYVQANPVEGGKQAVAEAYRNLSAVGATPLATTDNMNFGNPEKPEIMGQFVGAIKGISAAVAALDMPIVSGNVSLYNETDGTAILPTPTIGAVGLIAHLDDVIGCDVRDGHVALVLGETHGHLGQSAILSEVYNRAEGDAPPVDLDQEKAHGDFIRANRAYIKACTDLSDGGLALAAFEMAENAGVGVCLDASDTATLFGEDQGRYLIACNFDQAEALMIAASQAGLTLTSVGKFTGQAVRFGASSAPLAELSDVYRQSFGAALA
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Q163V9
Q2SYN3
HBOH_BURTA
D-(-)-3-hydroxybutyrate oligomer hydrolase
pseudomallei group
MTTIRGGSRRASLPALALLGVLLGACHSDDNAQVNTLPGFVSGNVRKTAYDGASDDLLTAGLGKTGLGSDTRPGFANPAQPTAAELRRLAIYSNYRALVDITPNGGYGRFWGPNVDLAGNDTLGEGKIAGTEYLAYSDDGSGRKNVTLLVQVPASFDPANPCIVTATSSGSRGVYGAIAAAGEWGLKRGCAVAYNDKGGGNGAHEIGTGVVTLIDGTLASASSAGSASLFTASESSSALAAFNSAFPNRYAYKHAHSQQNPEQDWGRVTLQAVEFAYWALNEQFGPAIDGARHGVRYRPGDITTIAASVSNGGAAALAAAEQDTRGWITAVVVGEPQINVRMTPGVTVEQGGVPAPSFGRPLADYATLANLLQPCAAAAVAAVGAPYLSALPVGLTQSIRVQRCATLAAAGLVSGADTASQANDALAQLHAAGYLADSDLLQAPMWDSQAIPAIAVTYANAYTRSRVTDNLCNFSFATTNSVTGAVAPPATSPMTSLFGAGNGVPPTNGINLVFNGASGGVDHRLATPDASFAGAFCLRQLWTANQLGIGANVDAVRVAANLQRKPAIIVQGRSDALVPVNHASRAYVAQNSATEGRASQLSFYEVTNGQHFDAFLSVPGFDTRFVPVHYYDEQALNLMWNHLKSGAPLPPSQVIRTVPRGGVPGAAPALSTANLPPIVQSPGSNAITVNAGVIDVPL
Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.
Q2SYN3
C5FMY5
SUB3_ARTOC
Subtilisin-like protease 3
Microsporum
MGCIKVISVFLAAVAAVDARAFFHNRGGNDVIPNSYIVVMKDGVTAEDFDSHISSVATTHSINKAKRGSETVGHKDSFNINGWRAYNGHFDEATIESILNDDKVDYVEHDRVVKLAALTTQPNAPTWGLGRVSHKAPGNKDFVYDSSAGQGVTIYGVDTGIDINHPEFRGRIRWGTNTVDNDNTDGNGHGTHTAGTFAGTTYGVAKKANIVAVKVLSAGGSGSTAGVIKGIDWCVTDAKAKGALGKAALNLSLGGAFSQANNDAVTRAQNAGIFVAVAAGNDNKDAKNSSPASAPAVCTAASSTIDDQKSSFSNWGTIVDIYAPGSNILSAAPGGGTRTLSGTSMASPHVCGVGAAMLAQGVSVAQACDRIKQIANAVIKNPGTGTTNKLLYNGSGR
Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity.
C5FMY5
Q3J1W3
CHEB2_CERS4
Protein-glutamate methylesterase/protein-glutamine glutaminase 2
Cereibacter
MKVGNTLMAARAREGRTRVLIVDDSAMVRQALALGLSTDPRLEVVGTASGAEAARAQMAALKPDVVTLDLEMPQMDGLTFLRSYMESAPVPTVVISSLTRTSGETAMRAMEAGAVDIISKPSLGAGQGLPAIMRDVCARVWAAARARLAPPDGAAPAPVATGASEDWIHALGASTGGVQALSRILPFFPAQSPGLLVVQHMPEGFTAAFARRLDALCRMRVREAADGDLVLPGLVLIAPGGLRHMEIERAGGVCRVRLVAGAPVSYSRPSVDRMFLSLAAAAGPRVSAALLTGMGRDGAAGLLAIRRAGGRTFAQDEGSSAVFGMPLAARDLRAAEEILTLDDIPARMMLAAAADTRAPSLASND
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Q3J1W3
P07188
LCP3_DROME
Larval cuticle protein III
Sophophora
MFKILLVCSLAALVAANANVEVKELVNDVQPDGFVSKLVLDDGSASSATGDIHGNIDGVFEWISPEGVHVRVSYKADENGYQPQSDLLPTPPPIPAAILKAIAYIEANPSKN
Component of the larval cuticle.
P07188
Q96303
PHT14_ARATH
H(+)/Pi cotransporter
Arabidopsis
MAREQLQVLNALDVAKTQWYHFTAIIIAGMGFFTDAYDLFCISLVTKLLGRIYYHVEGAQKPGTLPPNVAAAVNGVAFCGTLAGQLFFGWLGDKLGRKKVYGMTLMVMVLCSIASGLSFGHEPKAVMATLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFVSAVFAMQGFGIMAGGIFAIIISSAFEAKFPSPAYADDALGSTIPQADLVWRIILMAGAIPAAMTYYSRSKMPETARYTALVAKDAKQAASDMSKVLQVEIEPEQQKLEEISKEKSKAFGLFSKEFMSRHGLHLLGTTSTWFLLDIAFYSQNLFQKDIFSAIGWIPPAQSMNAIQEVFKIARAQTLIALCSTVPGYWFTVAFIDVIGRFAIQMMGFFFMTVFMFALAIPYNHWTHKENRIGFVIMYSLTFFFANFGPNATTFVVPAEIFPARFRSTCHGISAASGKLGAMVGAFGFLYLAQNPDKDKTDAGYPPGIGVRNSLIVLGVVNFLGILFTFLVPESKGKSLEEMSGENEDNENSNNDSRTVPIV
High-affinity transporter for external inorganic phosphate. Acts as a H(+):phosphate symporter in both low- and high-Pi conditions. Confers sensitivity to arsenate.
Q96303
Q21WX8
LPXA_ALBFT
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Rhodoferax
MTTIHATAIVDSQAQLDSSVTVGPYSLIGPNVKVGAGTTIGPHCVIEGHTTIGRDNRIFQFSSLGAIPQDKKYAGEPCELVIGDRNTIREFCTFNIGSPGDLGVTRVGDDNWLMAYVHLAHDCVVGNKTIFANNSQLAGHVHVGDWAILGGFTVVHQFVKIGAHSMTALCTVLLADLPPFVMCQGQPAQARSMNYEGLRRRGFSPERIAVVKAMHKALYRESLTLQLARERIADLVKNSPESLPDVEMMLLFLEQTSPQRGIVR
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Q21WX8
A1XIM6
MEP4_TRIVO
Fungalysin MEP4
Trichophyton
VHSVVDYVSAAEYQVYPWGINDPTEGNRTTLHLPWLKTLSTDWHIDGKGWYSTTRGNNAIAQENPTGGPEYENNYRPKSPLFIFKYPYSKAMTPPSSYRDASITQLFYTTNVYHDVLYILGFNEKAGNFQINNWNKGGVGGDYAILNSQDGSGVNNANFATPPDGQPGRMRMYTWNASIPERDGCFEAGIVIHEYTHGVSNRLTGGPENSRCLAALESGGMGEGWSDFFATAIRLKPGDTRATDYTMGEWASNRPNGIRKYRYSTSLTTNPHMYVDADGLTSVHAIGNIWASMLYELLWNLIDKHGKGDVTKIRPVLKNGVPTDGRHLAMKIVLDGMALQPCLPNFVQARDAILDADKNLTQGSNKCEIWKAFAKRGLGVGAVFNLSKRTGS
Secreted metalloproteinase probably acting as a virulence factor.
A1XIM6
Q2T281
ARGB_BURTA
NAG kinase
pseudomallei group
MSEPIDLSQISPSLKAEILAEALPYIRRYHGKTVVIKYGGNAMTEERLKQGFARDVILLKLVGINPVIVHGGGPQIDQALKKIGKQGTFIQGMRVTDEETMEVVEWVLGGEVQQDIVTLINHFGGHAVGLTGKDGGLIHARKLMMPDRDNPGEYVDIGQVGEVEAINPAVVRALQDDAFIPVISPIGFGEDGLSYNINADLVAGKLATVLNAEKLVMMTNIPGVMDKEGNLLTDLSAREIDALFEDGTISGGMLPKISSALDAAKSGVKSVHIVDGRIEHSVLLEILTEQPFGTMIRSH
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Q2T281
Q1IX87
RL6_DEIGD
50S ribosomal protein L6
Deinococcus
MSRIGRQPIAVPNGVTVNAQNGVFTAKGPKGELSVPYNTALNITQENGQLLVTRPSDRQEHRALHGLTRTLVANAVKGVSDGYTINLELRGVGYRARLVGKNLELTIGYSHPVVIEPPAGVTFAVPEPTRIDVMGIDKQLVGQVAANVRKVRKPDAYHGKGVRFVGEQIALKAGKAGATGGKGKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q1IX87
Q89LF9
PCS_BRADU
CDP-diglyceride-choline O-phosphatidyltransferase
Bradyrhizobium
MILWRIVRPGAAMAYVQTGLVLIAEAMDTQQDSLKPRPAMRAAAFSVHVFTAFGAAIALLAMLEAVREHWAAMFQWLGVALIIDAIDGPIARRLDVKNVQPNWSGDVLDLVVDFVTYVFVPAYAIVASGLLLPVAAPLLGVAIIVTSALYFADLRMKADDNHFRGFPALWNAAAFYLFLLHWPPLWSTLLVAALVVLTFVPFHVLHPVRVVRLRWLTMSLIGIWAVLSLYTLDMDFRVGPGVTLALCAIALWISFSDALIRFARSFA
Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP.
Q89LF9
Q0TPW8
VATB_CLOP1
V-ATPase subunit B
Clostridium
MLKEYRTVTEVVGPLMAVEGVEGVKYDELVEIEMQTGELRRGKVLEVNGDKAMVQLFEGSAGINLKNTKVRFLGRPLEIGVSEDMLGRVFDGMGRPKDNGPNIIPEKRLDINGEAINPVARNYPSEFIQTGISAIDGLNTLVRGQKLPVFSGSGLPHKELAAQIARQAKVLNSDSKFAVVFAAIGITFEEAEFFVDEFTKTGAIDRSVLFMNLASDPAIERIATPRMALTTAEYLAYEKGMHVLVIMTDITNYCEALREVSAARKEVPGRRGYPGYLYTDLSTLYERAGRLVGKEGSITQIPILTMPEDDKTHPIPDLTGYITEGQIILSRELYKKGIMPPIDVLPSLSRLKDKGIGKGKTREDHADTMNQLFSAYAQGKQAKELAAILGESALSDVDKAYAKFAEAFENEYVSQGFTTNRTIEETLNLGWKLLKILPRTELKRIRDEYLEKYMPVGEDE
Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.
Q0TPW8
A5CCA2
RECR_ORITB
Recombination protein RecR
Orientia
MHKDSNIIEELIFSFAQLPGLGNRSARRIVLYLMQDKEVRIKNLNNQLTSVLNNIMECDYCGNLDVVSICNICRHSERDSSIIAIVESVADLWALERSKVFKGWYHVLGKTLSAVSGNDAINSLKLPKLLNRIREYKVQEIILATNSTIDGQMTAFFVIDYLKDENLKISKLASGIPLGGELDYLDEGTLLAAFKARQSHDLL
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
A5CCA2
Q466A3
COFH1_METBF
FO synthase subunit 2 1
Methanosarcina
MNNRIPEDLIERAYQGKSTKEDGLLLLEVPPFELFRFADELRSLTAGDTVTYVVNRNINFTSRCVGTCGFCAFRTNDGKVLSIEEIMEKVREAEKAKATEVCIQGGLLPDVGLDFYQEIAESIKAEFPEMHIHAFSPMEVYHASHISGIKVSEALSKLKRSGLDTMPGTAAEILSDRVRKIICPSKLRTAEWIEVVTQAHAAGIPTTATMMYGHVETPEERIEHILTIREIQKETGGITEFVPLPFMPYNNPVGEKIIREGRYATPGLDDLKIYAISRILLHGHVDNIQASWVKLGKKLSQFALQCGANDLGGTLMEESISRLAGAPNGESISVEELEWMIYGAGRVPKERTTLYKGVRELASRNPGRITGCGASE
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
Q466A3
Q1C5H3
HSCB_YERPA
Hsc20
Yersinia
MDYFTLFGLPARYLIDGNQLTTRYQELQRQFHPDRFATQPERERLASMQQAATINDAYQTLKHPLKRAEYMLSLQGFDLGNEQHTMRDTAFLMEQLELREELDAIERKPDAETLLAEFSRRVAQMTTTRTQQMVEQLDAQLWVQAADTVRKLRFLDKLQQQVEQLEERLFDDFA
Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA.
Q1C5H3
Q6GPB6
KCMF1_XENLA
RING-type E3 ubiquitin transferase KCMF1
Xenopus
MSRHEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRTNMHFTSSSTGGLSSSQSSYSPSNREAMDPIAELLSQLSGVRRSTGGQLNSSGPSASQLQQLQMQLQLERQQAQAARQQLETARNATRRNNASNVTTTITQSTAATNTSSTENNQQSIQNSQFLLTRLNDPKMTEAERQSIESERADRSLFVQELLLSTLMQEESSSSDEDERGEIADFGAMGCVDIMPLDVALENLNLKESNKGNEPPPPPL
Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
Q6GPB6
Q5I2J3
TBA_GIBZE
Alpha-tubulin
Fusarium
MREVISINVGQAGCQIANSCWELYCLEHGIQPDGYLTEERKAQDPDQGFSTFFSETGNGKHVPRAIYCDLEPNVVDEVRTGAYRNLFHPEMMITGKEDASNNYARGHYTVGKELIDGVLDKIRRVADNCAGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQTATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGLERPNYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYSPVISAAKAAHEANSVQEMTMSCFEPNNQMVKCDPRHGKYMATCLLYRGDVVPNDAHAAVATLKTKRTIQFVDWCPTGFKLGICYQAPENVPNGDLAKVSRAVCMLSNTTAIAEAWSSLSLKFDLMHSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVATDSMGDEELEAEY
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q5I2J3
Q9ZAU2
DNRV_STRPE
Anthracycline biosynthesis protein DnrV
Streptomyces
MTRFAPGAPAWFDLGSPDVAASADFYTGLFGWTATVVSDPGAGGYTTFSSDGKLVAAVARHQIDTPYHRPYGPGNDQHGMPAIWTVYFATDDADALTKRVETAGGEVIMTPMDVLGLGRMAVFADPAGAAFAVWRKGVMEGAEVTGVPGSVGWVELVTDGIGAARDFYPATLGLAPADTGLKGVTDPVWHIGDTPVAGTQELGVTGAVRPHWAVLFAVHDCDATVRRAVELGGSVENEPADTPRGRRADLLDPHGAGFSVVELREGYPAAAGGAS
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. In vivo, it acts jointly with DoxA in the conversion of 13-deoxycarminomycin and 13-deoxydaunorubicin to yield carminomycin and daunorubicin, respectively. In vitro, it also acts jointly with DoxA in the C-14 hydroxylation of daunorubicin to form doxorubicin, although this strain is not a doxorubicin producer.
Q9ZAU2
A7ZIX5
ENTS_ECO24
Enterobactin exporter EntS
Escherichia
MNKQSWLLNLSLLKTHPAFRAVFLARFISIVSLGLLGVAVPVQIQMMTHSTWQVGLSVTLTGGAMFVGLMVGGVLADRYERKKVILLARGTCGIGFIGLCLNALLPEPSLLAIYLLGLWDGFFASLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPMIGGLLLATGGVAWNYGLAAAGTFITLLPLLSLPALPPPPQPREHPLKSLLAGFRFLLASPLVGGIALLGGLLTMASAVRVLYPALADNWQMSAAQIGFLYAAIPLGAAIGALTSGKLAHSARPGLLMLLSTLGSFLAIGLFGLMPMWILGVVCLALFGWLSAVSSLLQYTMLQTQTPEAMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVLLLLVLVELRRFRQTPPQVTASDS
Component of an export pathway for enterobactin.
A7ZIX5
O35082
KLOT_MOUSE
Klotho peptide
Mus
MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWARFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPSDSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYPESMKNNLSSLLPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQLLSWIDLEYNHPPIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIEDNGFPPLPENQPLEGTFPCDFAWGVVDNYVQVDTTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNHTVLHFYRCMISELVHANITPVVALWQPAAPHQGLPHALAKHGAWENPHTALAFADYANLCFKELGHWVNLWITMNEPNTRNMTYRAGHHLLRAHALAWHLYDDKFRAAQKGKISIALQADWIEPACPFSQNDKEVAERVLEFDIGWLAEPIFGSGDYPRVMRDWLNQKNNFLLPYFTEDEKKLVRGSFDFLAVSHYTTILVDWEKEDPMKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLRFKYGDLPMYVTANGIDDDPHAEQDSLRIYYIKNYVNEALKAYVLDDINLCGYFAYSLSDRSAPKSGFYRYAANQFEPKPSMKHYRKIIDSNGFLGSGTLGRFCPEEYTVCTECGFFQTRKSLLVFISFLVFTFIISLALIFHYSKKGQRSYK
The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
O35082
B1W0A2
ATPE_STRGG
F-ATPase epsilon subunit
Streptomyces
MAAELHVELVAADRSVWSGEATLVVARTTSGDIGVMPGHQPLLGVLESGPVTIRTSEGGTVIAAVHGGFISFADDKLSLLAEIAELADEIDVERAERALELAKSDADAAAQRRADVRLRAVAVR
Produces ATP from ADP in the presence of a proton gradient across the membrane.
B1W0A2
Q58655
HJA3_METJA
Probable archaeal histone 3
Methanocaldococcus
MAELPVAPCVRILKKAGAQRVSEAAGKYFAEALEEIALEIARKSVDLAKHAKRKTVKVEDVKAALRG
Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation (in vitro).
Q58655
Q57RT4
RLMH_SALCH
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Salmonella
MKLQLVAVGTKMPDWVQTGYTEYLRRFPKDMPFELIEIPAGKRGKNADIKRILDKEGEQMLAAAGKNRIVTLNIPGKPWDTPQLANELERWKQDGRDVSLLIGGPEGLSPACKAAAEQSWSLSALTLPHPLVRVLVAESLYRAWSITTNHPYHRE
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
Q57RT4
Q3M3H8
SYE_TRIV2
Glutamyl-tRNA synthetase
Trichormus
MTVRVRIAPSPTGNLHIGTARTAVFNWLFARHHGGTFILRIEDTDLERSRPEYTENIMTGLRWLGLNWDEGPFFQSQRLDLYQKAVKQLLDQGLAYRCYTTSEELEALREAQKAKGEAPRYDNRHRHLTPEQEAEFKAQGRSFVIRFKIDDEREIVWNDLVRGKMSWRGSDLGGDMVIARASENDTGQPLYNFVVVIDDIDMQISHVIRGEDHIANTAKQILLYEAFGAKIPEFAHTPLILNMEGRKLSKRDGVTSISDFQQMGFTSEGLVNYMTLLGWSPPDSTQEIFTLEAAAKEFTFERVNKAGAKFDWAKLDWLNSQYIHNTPVDQLTDLLIPYWEAAGYSFAGGRDRPWLEQLVGLLSASLTRLTDAVDMSKLFFSETVELSEEGSKQLQQEGSKAVLEAIIAALEAQTQLTENAAQDIIKQVVKAQNVKKGLVMRSLRVALTGDVHGPDLIQSWLLLNQIGLDKPRLSQAIAASL
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Q3M3H8
Q32KN0
ZN572_BOVIN
Zinc finger protein 572
Bos
MEQEQKLLVSDSNGLTKKESLKNTITGDESKNNLKTVQFSNSKADKERASKWSRSDGPENYKDEDTKEILLTGSQGGKTERDDSYENDSNLGSQRNCTEKEEEQPNHWGWSPGDHTGPAGQQNPSFGDKPYKCSECWKSFSNSSHLRIHQRTHSGEKPYRCSECGKCFSNSSHLIQHLRTHTGEKPYQCGECGKSFSNTSHLIIHERTHTGEKPYKCPECAKSLSSSSHLIQHHRSHTGEKPYECPLCGKCFSHSYVLVEHQRTHTGEKPYKCPDCGKSFSQSSSLIRHQRTHTGEKPYKCPECGKGFGCNSTLIKHQRIHTGEKPYQCIECGKNFSRSSNLVTHQKMHTDDKTYQSSEYEESLSQNYSLIEECRIQPGEKPYKCCECGKSFGLSSHLIRHQRTHTGEKPYRCSECWKTFSQSSTLVIHQRTHTGEKPYKCPDCGECFSQSFNLIRHRRTHMGEKPYKCTDCEKCFSRSAYLSQHRKIHVGKSFESPEVEDFPHEWTWKNYSGEIALIPSFSVPSSSPS
May be involved in transcriptional regulation.
Q32KN0
C0QA34
CSRA_DESAH
Translational regulator CsrA
Desulforapulum
MLVLTRKVGESIRISDDIVVKVIDIGKNRIRIGIDAPSTVSVLRNEVYEEIHQENILSSRGSVTDLAKAATLWARKSKKEE
A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.
C0QA34