accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q9A8S9
RPOA_CAUVC
Transcriptase subunit alpha
Caulobacter
MIERNWNELIRPEKPQIETGADATRKARIVAEPLERGFGVTLGNALRRVLLSSLQGAAVTAIQIDGVVHEFSSLEGVREDVVDIVLNIKQLAVRMHAEGPKRMTLRATGPGPVTAGQIETPADIEILNPDHVLCTLDDGASVRMEFTVNNGKGYVPADRNRPEDAPIGLIAVDALYSPVKRVAYRVEPTRQGQSLDYDKLILEVETNGAVTPVDAVAYAARILQDQLQIFITFEEPKAKSADESKPELPFNPALLKKVDELELSVRSANCLKNDNIVYIGDLIQKTEAEMLRTPNFGRKSLNEIKEVLAGMGLHLGMDVPNWPPENIEDLAKKFEDQI
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q9A8S9
Q8NFY9
KBTB8_HUMAN
T-cell activation kelch repeat protein
Homo
MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification . The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification .
Q8NFY9
Q4WI89
ATRR_ASPFU
ABC-transporter-regulating transcription factor
Aspergillus subgen. Fumigati
MDGIGDGTESMGFDMPMLMNQQPHLFGSYGHDGSPVAPIFSNPTFQDEPSIGAADDNSDAKRRRIARACDMCRKKKIKCDGKMPKCSHCTNYKTDCVFTQVEKKRNPPKGAKYIEGLENRLGRMESLLRLSGLLSEDDGGKTDLGTLEKRLADRYHASGSNTPHNPQKINIPSQSQIAMSQQNSSSHYSTPRLESQSSPRTAATSPESQKESETEVEGLSDMMCSLVTNNCGETRYIGSSSGFSIFSPKGIQWVNEKTGDNSFQEMISSAYVDDNKWMYWKPEIFSDIFARRVFKPLPPKDEAMSLFKDFFDNFNCMFPLYHEPTFMHLVERQYSRDPYEGSGWWASINVVLAIAHRLRVMSNLVPQEEDRKAWLYLKNAMGVLTELTMRNTDLLSVQALLGMSLFLQGTPNPQPSFFLVAAAIRLSHSIGLHKRGSGFGLNPVEVEQRKRVFWIAYLLDKDICLRSGRPPVQDDDDMNVELPSDDPPDNIGNVPLSDGRSKFNLFRSMCRFATIESKVYKRLYSAKASKQSDGELLNTIGELDKELEDWKDSIPLDFRPEHEIKASHTPLILHVVVLHFAYYNCLTTIHRMSVHHGYWTSRLSNYAIQGLNARPLNPRVFLSAVLCVTAARASINLIKYIPQGDFACVWLILYYPVSALVTLFANILQNPSDARARSDVKLMNVVVNFLSTLVSDESNGSIKRMLGLCGEFERIAKVVLDKAEKESYSKKKRKSPEEPVNLQQSTPEEHPAPSPSTTQPTQAPSRNVPMSSPLFAENPGDPGGNTMADDAGGFASSREIPGTTGVSTNIPPNIQAMPGIAQDYQDMLSPDPLEGVSFADQPPYSATANTPLSSFQQPFVPQDLWQMPMTIEWDWADMSTNFPVFDTNGPPHGGL
Transcription factor that regulates expression of the genes related to ergosterol biosynthesis, including erg3B, erg24A, erg25A, as well as cyp51A that encodes a target protein of azoles . Responsible for the expression of the ABC transporter abcC/cdr1B/abcG1 related to azole resistance . Directly binds both the cyp51A and abcC/cdr1B/abcG1 promoters at a conserved 34 bp region called the atrR response element (ATRE) . AtrR also binds to the promoter regions of both the sterol response transcription factor srbA and atrR genes themselves, the latter suggesting the possibility that atrR is autoregulated . AtrR is necessary for hypoxia adaptation and virulence .
Q4WI89
P48624
FAD3E_BRANA
Omega-3 fatty acid desaturase 3, endoplasmic reticulum
Brassica
MVVAMDQRSNVNGDSGARKEEGFDPSAQPPFKIGDIRAAIPKHCWVKSPLRSMSYVTRDIFAVAALAMAAVYFDSWFLWPLYWVAQGTLFWAIFVLGHDCGHGSFSDIPLLNSVVGHILHSFILVPYHGWRISHRTHHQNHGHVENDESWVPLPEKLYKNLPHSTRMLRYTVPLPMLAYPIYLWYRSPGKEGSHFNPYSSLFAPSERKLIATSTTCWSIMLATLVYLSFLVDPVTVLKVYGVPYIIFVMWLDAVTYLHHHGHDEKLPWYRGKEWSYLRGGLTTIDRDYGIFNNIHHDIGTHVIHHLFPQIPHYHLVDATRAAKHVLGRYYREPKTSGAIPIHLVESLVASIKKDHYVSDTGDIVFYETDPDLYVYASDKSKIN
ER (microsomal) omega-3 fatty acid desaturase introduces the third double bond in the biosynthesis of 18:3 fatty acids, important constituents of plant membranes. It is thought to use cytochrome b5 as an electron donor and to act on fatty acids esterified to phosphatidylcholine and, possibly, other phospholipids.
P48624
C3PKP0
RS7_CORA7
30S ribosomal protein S7
Corynebacterium
MRKNAAPKRPVVKDPVYNSEQVTMLVNKILRDGKKSTAERIVYGALEVCREKTGTDPVGTLEKALGNIRPDLEVRSRRVGGATYQVPVEVKPARSNTLALRWLVTFTRQRRENSMIERLANEILDASNGLGASVKRREDTHKMAEANRAFAHYRW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
C3PKP0
Q50186
RODA_MYCLE
Non-canonical transglycosylase RodA
Mycobacterium
MTTQLQPVVTVTPPLPTRRNAELLLLGFAAVITVAALAIVEANQERNFRWYLAGYGLIFWSLFASAHLAIRRFAPYTDPLLLPIVALLNGLGLVMIHRLDLVDNDVTGHHHTSAAQQMLWTLVGVAAFVLVMTVLKDHRQLARYGYISGLTGLVFLAIPAPLPEQNGAKIWIRFPGFSIQPAEFSKILLLIFFAAVLVAKRSLFTSAGKHLIGMTLPRPRDLAPLLAAWVISVSVMVFEKDLGTSLLLYASFLVVVYLATQRLSWVIIGLVLFTAGSTIAYFTFEHIRVRMQVWWDPFTNLDVGGYQIVQSLFSFATGGIFGTGLGNGQPDAIPAASTDFIIAVFGEELGLVGLAALLMLYTIVIVRGLRTAIATRDSFGKLLAAGLASTLAIQLFIVSGGVTTLIPLTGLTTPWMSYGGSSLLANYVLLAILARISHSARHPLRSRPHNTSPIAVASTEVIERV
Transglycosylase involved in peptidoglycan cell wall formation. Required for the regulation of cell length.
Q50186
Q8BMT4
LRC33_MOUSE
Negative regulator of reactive oxygen species
Mus
MEFPPLWLCLGFHFLIVEWRSGPGTATAASQGGCKVVDGVADCRGLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNLSSKIVRVVELPEGLPQGCKWEQVDTGLFYLVLILPSCLTLLVACTVVFLTFKKPLLQVIKSRCHWSSIY
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system . Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1 . TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS . Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable).
Q8BMT4
B3PPF4
ACCA_RHIE6
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Rhizobium
MHNYLDFEKPISDLEGKIIELKKLATEDESIDTTDEIGRLEVRVREAILEIYSKLNAWQKTQVARHPQRPHFVDYAKTLFQEFTPLAGDRKFSEDAAIQAGLARFRGQPVAVIGQEKGNDTKSRLKHNFGSPRPEGYRKAIRILEMADRFGLPVISLVDTAGAYPGVGAEERGQAEAIARSTEMCLGVKVPLVSVVIGEGGSGGAIAIATGNRVYMLEHSIYSVISPEGAASILWRDSTRAREAATNMKITAEDLKSLGVIDGIISEPLGGAHRDPDSVIAATGDVIANALAEMSSRSGEQLRNERRQKFLNMGRNL
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
B3PPF4
A2S5U5
MURG_BURM9
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
pseudomallei group
MTSTQRTLMVMAGGTGGHVFPGLAVAHRMQAQGWRVVWLGNPAGMEATLVPRHGIPMEYVRFGGLRGKGLATKFALPFNLLRACAQSLRALRRVKPDVVLGMGGYITFPAGLVTVLTGRPLVLHEQNSIAGLTNKVLAKLAKRVLVAFPGALPNAEWTGNPIRTELARTEPPQARYAARSGKLRLLVVGGSLGAAALNEVVPRALALLAPDERPQVVHQAGAKHIDTLKENYEAAGLSCGSDVALVPFIDDMASAYANADLVICRSGAMTVAEIAAVGVAALFVPFPHAVDDHQTTNAEFLAEQGAAVLVQQRDLSAELLADWLRGQSRDSLAAMAERSRSLAKPDATDEVARVCAAVAGANLEGKQ
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
A2S5U5
B8DW26
RS14Z_BIFA0
30S ribosomal protein S14 type Z
Bifidobacterium
MAKTCLKVKALRKPKFKVRAYTRCMVCGRPHSVYRKFGLCRICLREKAHRGELPGVTKSSW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
B8DW26
Q4WC50
MFSA_ASPFU
Major facilitator superfamily transporter mfsA
Aspergillus subgen. Fumigati
MWTTTSGLSGRSLRLSITFAAVVGFSLFGYNQGMMAGLLNGDEFVNSFPILKMPDNPTAGEKHYIDVIRGAVTSCYELGCFFGALFSMFCGNRLGRTRLIFMGASILIVGALLTTVCYTGKWEVGQFVIGRVVSGIGNGMNTATIPVWQSECSGAHNRGFLVCFEGAMIAGGTFIAYWVVFGISHAADSVQWRFPVALQIFFALVVATGALMLPDSPSWFVSRGLDNEACEVLGKIKGTSPDSDQVLHDFNLIKTDMESTKSEQSNWKTVFTFGKTQEFQRLLIGCSGQFFQQFTGCNAAIYYSTLLFQENLHMEKYLSLIMGGVFASVYALATIPSFFMIERVGRRKLYLIGFLGQGLSFVITFACLIKETEENSKGAAVGIFLFITFFAFTLLPLPWIYPPEINPLRTRTVGASASTCTNWMCNFAVVMFTPLFAGQSPWGVYLFFALFNFVGLIFGYFFYVETAGRELEEVDIIYAKAHVEGKMPFRVAHDLPKLSFEEIVQQSRELGLDTNDHVMLEKKELGLSSDSAQETEEVYEKQ
Major facilitator superfamily transporter that may be involved in A.fumigatus adaptation to azoles such as vorizonazole.
Q4WC50
Q87J41
NADE_VIBPA
NH(3)-dependent NAD(+) synthetase
Vibrio
MEQSIRDEMRVLPSIDPHFEIERRIAFIKRKLQEAGCKSLVLGISGGVDSTTLGRLAQLAVDQLNEETGSNDYQFIAVRLPYGEQKDEDEAQLALSFIKPTHSISVNIKQGVDGMHAASNIALEGTGLMPEDAAKVDFVKGNVKARARMIAQYEIAGYVGGLVLGTDHSAENITGFYTKFGDGACDLAPLFGLNKRQVREVAATLGAPEVLVKKVPTADLEELAPQKADEDALNLTYEQIDDFLEGKPVSQQVVDRLVSIYKATQHKRQPIPTIYD
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
Q87J41
Q9Y2D4
EXC6B_HUMAN
SEC15-like protein 2
Homo
MERGKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFMEKLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVLEMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLDNIVLQQPRIGSKRKSKKDAYIIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRKQARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADTLQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGIFRNILDSDNYSPIPVTSEEMYKKVVGQFPFQDIELEKQPFPKKFPFSEFVPKVYNQIKEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTTKLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGNKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQLLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQLLDLFIQWDWSTYLADYGQPNCKYLRVNPVTALTLLEKMKDTSRKNNMFAQFRKNERDKQKLIDTVAKQLRGLISSHHS
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Q9Y2D4
B9LRD9
RS10_HALLT
30S ribosomal protein S10
Halorubrum
MQQARVRLAGTSPEDLDDICADVREIADSTGVALSGPIPLPTKTLEIPSRKSPDGEGTATWEHWEMRVHKRLIDIDADERALRQLMRVQVPNDVSIEIVLED
Involved in the binding of tRNA to the ribosomes.
B9LRD9
Q96LW1
Z354B_HUMAN
Zinc finger protein 354B
Homo
MAAGQREARPQVSLTFEDVAVLFTWDEWRKLAPSQRNLYRDVMLENYRNLVSLGLSFTKPKVISLLQQGEDPWEVEKDSSGVSSLGCKSTPKMTKSTQTQDSFQEQIRKRLKRDEPWNFISERSCIYEEKLKKQQDKNENLQIISVAHTKILTVDRSHKNVEFGQNFYLKSVFIKQQRFAKEKTPSKCEIQRNSFKQNSNLLNQSKIKTAEKRYKCSTCEKAFIHNSSLRKHQKNHTGEKLFKCKECLKAFSQSSALIQHQRTHTGEKPYICKECGKAFSHSASLCKHLRTHTVEKCYRCKECGKSFSRRSGLFIHQKIHAQENPHKYNPGRKASSYSTSLSGSQKIHLRKKSYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCNECGKGFTSISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECDKTFRCNSSLSNHQRIHTGEKPYRCLECGMSFGQSAALIQHQRIHTGEKPFKCNTCGKTFRQSSSLIAHQRIHTGEKPYECNACGKLFSQRSSLTNHYKIHIEEDSLKADLHV
May be involved in transcriptional regulation.
Q96LW1
B3EMI1
RECX_CHLPB
Regulatory protein RecX
Chlorobium
MADTDDKKAFDLAIRLLGEREHSRKEIITKLERRKFSEAAIDKTLERLDQLGLIDDRSFAEHFVGSRSRKKPSGKYKLRYELFQKGISETIIDEILSDYDSSAHCLDAAMKKFPFLKGDDHYKRKKLYAFLANRGFDSHSIRETLDQIFRS
Modulates RecA activity.
B3EMI1
Q9HCJ3
RAVR2_HUMAN
Protein raver-2
Homo
MAAAAGDGGGEGGAGLGSAAGLGPGPGLRGQGPSAEAHEGAPDPMPAALHPEEVAARLQRMQRELSNRRKILVKNLPQDSNCQEVHDLLKDYDLKYCYVDRNKRTAFVTLLNGEQAQNAIQMFHQYSFRGKDLIVQLQPTDALLCITNVPISFTSEEFEELVRAYGNIERCFLVYSEVTGHSKGYGFVEYMKKDFAAKARLELLGRQLGASALFAQWMDVNLLASELIHSKCLCIDKLPSDYRDSEELLQIFSSVHKPVFCQLAQDEGSYVGGFAVVEYSTAEQAEEVQQAADGMTIKGSKVQVSFCAPGAPGRSTLAALIAAQRVMHSNQKGLLPEPNPVQIMKSLNNPAMLQVLLQPQLCGRAVKPAVLGTPHSLPHLMNPSISPAFLHLNKAHQSSVMGNTSNLFLQNLSHIPLAQQQLMKFENIHTNNKPGLLGEPPAVVLQTALGIGSVLPLKKELGHHHGEAHKTSSLIPTQTTITAGMGMLPFFPNQHIAGQAGPGHSNTQEKQPATVGMAEGNFSGSQPYLQSFPNLAAGSLLVGHHKQQQSQPKGTEISSGAASKNQTSLLGEPPKEIRLSKNPYLNLASVLPSVCLSSPASKTTLHKTGIASSILDAISQGSESQHALEKCIAYSPPFGDYAQVSSLRNEKRGSSYLISAPEGGSVECVDQHSQGTGAYYMETYLKKKRVY
May bind single-stranded nucleic acids.
Q9HCJ3
A1AR94
PDXJ_PELPD
Pyridoxine 5'-phosphate synthase
Pelobacter
MAKLGLNVDHVATVRQARGGMEPDPVTAAALGELAGAEGITIHLREDRRHIQDRDLEILRRTVKTKLNLEMAATQEMVRIALRTKPEQVTLVPEKRQELTTEGGLDVILNLKAITDAVKRLRDGGIVVSLFVDPDQEQIKAANKSGADYIEIHTGAYADAPDWPSQKRQLEEIDAAIKLASKVGMGVNAGHGINYVNIKPLAALGGIEEYNIGHSIMARAILVGMDRAVKDMVELIKYA
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
A1AR94
A5F7R1
NHAA_VIBC3
Sodium/proton antiporter NhaA
Vibrio
MSDMIRDFFKMESAGGILLVIAAAIAMVIANSAMGEGYQAFLHTYVFGMSVSHWINDGLMAVFFLLIGLEVKRELLEGALKSRETAIFPAIAAVGGMLAPALIYVAFNFNDPAAIQGWAIPAATDIAFALGIMALLGKRVPVSLKVFLLALAIIDDLGVVVIIALFYSSDLSTIALTIGFIMTGVLFMLNAKHVTKLSIYLVAGLILWIAVLKSGVHATLAGVVIGFAIPLKGNKGEHSPLKHLEHALHPYVAFAILPVFAFANAGISLQGVSLAGLTSMLPLGVALGLFLGKPLGIFSFSWAAVKLGVAKLPEGINFKHIFAVSVLCGIGFTMSIFISSLAFGQANEAYDTYARLGILMGSTTAALLGYSLLRLSLPLKKA
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
A5F7R1
P16169
GUNA_RUMFL
Cellodextrinase A
Ruminococcus
MLKSRGIIKGINLGGWMSQCDYSRERLDNFVKENDIKQIADWGFDHVRLPIDYNIVQNNDGSVIEDGYNRIDKVVELCRKYGLKLVIDLHKTAGFSFDFGEPESGFFDNKEYQERFYILWEEIARRYGHDTDNIVFELLNEVTDEAFIGKWNEISDICIGRIRKIAPEVIILLGSYHNNAADTVQFLNAPHDDRVVYNFHCYEPLKFTHQGATWTPDIIPGERMKFEDSETSEAYFEELFSTAISTAEKYGTTLYCGEYGVIDVVSAEDSLKWFKVINKVFSKHGISRECGITRKWTSAFPTASTTATVRDTEVSVIKTRKAHNCCTLTEVFTRVY
Crystalline cellulose degradation.
P16169
A0RJ47
OBG_BACAH
GTP-binding protein Obg
Bacillus cereus group
MFVDQVKIYVKGGDGGNGMVAYRREKYVPKGGPAGGDGGKGADVVFIVEEGLRTLMDFRYQRHFKADRGQHGMSKGQHGRKSEDLLVKVPPGTVVKDEKTGQILADLVTHGQTAVIAKGGRGGRGNSRFATATNPAPEIAENGEPGQERDVILELKVLADVGLVGFPSVGKSTLLSVVSSARPKIAEYHFTTIVPNLGVVETGDNRSFVMADLPGLIEGAHAGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYEDYVTINNELKEYNLRLTERPQVVVANKMDMPDAEENLQAFKEKVGDEVKIFPISAVTKQGVRDLLFEVANLIETTPEFPIHEVVDESDTSVMYKFETEGVKFDITRESDGTFVISGYDIEKTFKMTDFSRDESVRRFARQMRGMGIDEALRARGAKDGDIVKILEYEFEFID
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
A0RJ47
Q03F74
PFKA_PEDPA
Phosphohexokinase
Pediococcus
MKRIGIMTSGGDAPGMNLAIRAVARKALSSGLEAYGINYGFAGLVAGDIHEFKAADLDDMVSQGGTMLYSARYPEFAQEESQLKGIEQLKKFGIDALVVIGGDGSYHGALRLTEHGYNTIGLPGTIDNDIPFTDFTIGFDTALNTAVDAIDKIRDTAKSHQRVFAVQVMGRNAADIALWAGVASGADAVIAPGFDYDVEAIANKLKKNRANGKDYGIIVIAEGDANSDAAPEFIDQLKQYGDFDARATVIGHVQRGGVPSAKDRVLASKMGAYAVELLLEGKGGLAVGILENKVQAHNMLDLFDAKHQADDSLYQLSEDLSF
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Q03F74
P19371
IPYR_DESVH
Pyrophosphate phospho-hydrolase
Desulfovibrio
NYTIGNDNVLTEPLSEIKTAGLMYKMGVQ
Inorganic pyrophosphatase is an essential enzyme for the activation of sulfate by sulfate reducing bacteria. This is a high activity pyrophosphatase.
P19371
A5CXM1
RS5_VESOH
30S ribosomal protein S5
Candidatus Vesicomyosocius
MAGYKENNNIDNNYIEKLVNIRRVVKVVKGGRIFGFSALVVVGDGNGKVGYGTGKAREVPVAIQKAMDKARKAMKNVPLVNGTLHYSIISNVGAAKVYMQPASEGTGVIAGGPMRSVLEAVGVHNILAKCNGTRNPISVVRATVEGLTSMLSPQLVATKRGMTVDQITGEE
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
A5CXM1
B5FRC1
ACPS_SALDC
4'-phosphopantetheinyl transferase AcpS
Salmonella
MAILGLGTDIVEIARIEAVISRSGERLARRVLSDNEWAIWETHQQPVRFLAKRFAVKEAAAKAFGTGIRNGLAFNQFEVFNDELGKPRLRLWGEALTLAEKLGVAHMHVTLADERHYACATVILES
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
B5FRC1
Q8E7X6
RECO_STRA3
Recombination protein O
Streptococcus
MRVSQTYGLVLYNRNYREDDKLVKIFTETEGKRMFFVKHASKSKFNAVLQPLTIAHFILKINDNGLSYIDDYKEVLAFQETNSDLFKLSYASYITSLADVAISDNVADAQLFIFLKKTLELIEDGLDYEILTNIFEVQLLERFGVALNFHDCVFCHRVGLPFDFSHKYSGLLCPNHYYKDERRNHLDPNMLYLINRFQSIQFDDLQTISVKPEMKLKIRQFLDMIYDEYVGIHLKSKKFIDDLSSWGSIMKSD
Involved in DNA repair and RecF pathway recombination.
Q8E7X6
Q4KC13
UPPP_PSEF5
Undecaprenyl pyrophosphate phosphatase
Pseudomonas
MDLWTAAQALILGIVEGLTEFLPISSTGHQIIVADLLDFGGERAMAFNIIIQLGAILAVVWEFRRKILDVVIGLPTQPKAQRFTINLLIAFLPAVVLGVIFADLIHAYLFNPITVATALVVGGLIMLWAERRQHQVHAETVDDITWKDALKVGCAQCLAMIPGTSRSGSTIIGGLLFGLSRKTATEFSFFLAMPTMVGAAVYSGYKYRHLFQPDDFPVFAIGFVTAFVFAMIAVKGLLKFIASHSYAAFAWYRIAFGLLILATWQFGWVDWTAAKP
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q4KC13
Q057V1
RNT_BUCCC
Exoribonuclease T
Buchnera
MFIYKDINYAINNRFRGFYPVVIDIESAGFQADTDALLEIAIVTLKMNKSGWLKIDDRLHFHIIPFKGSIIKAESVAFNKIDPFNPLRGAVSEKNALKNIFKLVRKKININKCRKGILVAHNANFDHNFLMAASKRVGNLNNPFHPFTTFDTAALSGLIFGQTVLAKACKLAGIPFDTNQAHSALYDTIQTAYLFCELVNRWKRLGGWPPNSSHRKKTDEI
Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.
Q057V1
Q5LY40
MUTS2_STRT1
Endonuclease MutS2
Streptococcus
MNTKILDQLEFNKVKDQFTEYLQTEQAQAELCDLVPMTNPERIQNQFTEIQEMSEIFVEHHGFAIGSLRDISEPLRRLELDADLNIQELIAIKKVLQASADLSRFYADLENVELIALKRLFEKIEAFPSLQGSLQSINDGGFIEHFASPELQNIRRQLKACDDAIRQTLQDILKKSGHMLAENLIASRNGRSVLPVKNTYRNRIAGVVHDISSSGNTVYIEPRAVIQLNEKITQLRADERHEMARILHELSDQLRPHTAAIANNAWILGHMDFIRGKYLYLHDKKAIIPEISDNQTLQLLNVRHPLLINPVANDLRFDEDLTVIVITGPNTGGKTVMLKTLGLAQLMAQSGLPILADKGSRVAIFQEIFADIGDEQSIEQSLSTFSSHMTHIVEILNTADSNSLVLVDELGAGTDPQEGASLAMAILEHLRLSQIKTMATTHYPELKAYGIETQHVENASMEFDTATLRPTYRFMQGVPGRSNAFEIARRLGLNEIIVKEAENLTDTDSDVNRIIEQLEAQTVETQKRLEHIKDVEQENLKFNRAVKKLYNEFSHEYDKELEKAQKEIQEMVDTALAESDSILKNLHDKSQLKPHEVIDAKGKLKKLAAQVDLSKNKVLRKAKKEKAARAPRVGDDIIVTAYGQRGTLTSQAKNGNWEAQVGLIKMSLKADEFTLVRTQAEAQQPKKKQINVVKKAKKTSSDGPRARLDLRGKRYEEAMQELDAFIDQALLNNMSQVEIIHGIGTGVIRDAVTKYLRRHRHVKNFEYAPQSAGGSGCTIATLG
Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.
Q5LY40
P49660
SSR4_MOUSE
Somatostatin receptor type 4
Mus
MNAPATLPPGVEDTTWTPGINASWAPDEEEEDAMGSDGTGTAGMVTIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFARSAAALRHWPFGAVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLATATYRRPSVAKLINLGVWLASLLVTLPIAVFADTRPARGGEAVACNLHWPHPAWSAVFVIYTFLLGFLPPVLAIGLCYLLIVGKMRAVALAGGWQQRRRSEKKITRLVLMVVTVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRSFQRVLCLRCCLLETTGGAEEEPLDYYATALKSRGGAGCICPPLPCQQEPVQAEPGCKQVPFTKTTTF
Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.
P49660
Q46AR1
THI4_METBF
Thiamine thiazole synthase
Methanosarcina
MELDEVIITRAIFDEYSKTFLDYTEVDVALIGGGPANLVAARYLAEAGAKVAIYEQKLSLGGGMWAGGMMFPRIVVQEEACRILDDFGIRYKEYQPGYYVANSVESVGKLISGATSAGAEVFNLVSFEDVMIRENDRVTGIVVNWGPVTVQRLHVDPLMIRTKLVIDGTGHEAVVCNTILRKIPNAKIGNLGKLGEKPMWSEVGEQLVVDATKEIYPGLIVAGMAANAATCSPRMGPVFGGMLLSGEKAAKLALEKLKEL
Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
Q46AR1
P43429
GATA1_RAT
NF-E1 DNA-binding protein
Rattus
MDFPGLGALGTSEPLPQFVDSALVSSTSDSAGFFSSGPESLDTASSSTSPNAATAAATALAYYREAEAYRHSPVFQVYPLLNSMEGIPGSSPYASWAYSKTALYPASTVCPSHEDAPSQTLEDPDGKNNNTFLETLKTERLSPDLLTLGTALPTSLPVTSSAYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPLAPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLAGAGAAEGPAGGFMVVAGGSSSGNCGEVAPGLTLGTAGTAHLYQGLGPVVLSGPVSHLMSFPGPLLGSPTASFPTGPVPTTTSTSVVSPLSS
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS.
P43429
B4RBX8
SYE_PHEZH
Glutamyl-tRNA synthetase
Phenylobacterium
MPDRPVRTRIAPSPTGMMHIGTARTALFNWLYARHTGGKFLLRIEDTDRERSTDEAVKVIFDGLKWLGLDADEPPVFQFARADRHREAAETLLARGGAYRDYMTPEELEAEREVARAEGRVVRSPWRDASPNDAPDRPFVVRLKAPQEGETVIQDAVKGEVRFQNKQLDDLILLRTDGTPTYNLAVVVDDHDMGVTHVIRGDDHLNNAARQTLIYQGLGWEVPVWAHLPLIHGPDGAKLSKRHGAQAVSEFDSMGYLPETMRNYLAKLGWGHGDDEIFSDEQAIAWFDINDVVSAPARLDWAKLNHLNNHYIRQAEPARLAELVKTVLASRDWPLEAGDMAVIERTIPFVRDGAKTTLELADNVVFALKRRPLELPEKTRTQMTEELRGRLSRLREALAAVEYWDVPSLEAALRAFAEAEGVGLGKFGPQLRAVLSGGAPAPDLAGAMVALTRDESLGRLDDALSPSA
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
B4RBX8
P45062
MRAY_HAEIN
UDP-MurNAc-pentapeptide phosphotransferase
Haemophilus
MLVWLAEYLVRYETAFNAISYITVRANLALLTALFISLWIGPKVIKRLQILKFGQEVRNDGPESHFAKKGTPTMGGVMILFSIGVSTLLWANLANPYIWVCLFVLFGYGAIGFVDDFRKITRKNTDGLIARWKYFWMSVVALVAILWLYWLGHDTDATRLVIPFFKDIMPQLGLFYIVLSYFVIVGTGNAVNLTDGLDGLAIMPTALVAGAFALIAWATGNVNFAEYLHIPYIKYSSEVVVFCTAIVGASLGFLWFNTYPAQVFMGDVGSLALGGALGVVAILVRQEFLLVIMGGVFVVEALSVILQVGSYKLRKQRIFRMAPIHHHFELKGWPEPRVIIRFWIISLMLVLMGLVTLKLR
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
P45062
Q747Q5
NADD_GEOSL
Nicotinate mononucleotide adenylyltransferase
Geobacter
MKTGILGGTFNPVHVAHLRIAEEVRDTFALDRVLFIPAASPPHKAMEGEVPFETRCAMVRLATADNHAFAVSDMEGGRPGKSYSVDTIRALKEEYPGDEFFFIIGSDSFLDIGSWYDYEAIFASCNLVVAARPGAEAADLLAALPVAITAQFCYYPAEKRLAHRSGYSVYWLAGVPLDISSRSIRGLARLGRSIRYLVPEAVERYINEQRIYAHDG
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Q747Q5
Q04RD6
MTNA_LEPBJ
S-methyl-5-thioribose-1-phosphate isomerase
Leptospira
MQESGLKPILWTNKELILLDQRVLPGTTSYLKAKTLEDCIFAIREMVVRGAPAIAITGAFGIALYLNGLSSQPTFSQLKTKLDELLESRPTAVNLRLVIEEFFSRFPEADYSSANLEKMQKSAEEFALFMLEEDLENNLTLSKNALSLFPKSPSSLNIITHCNTGALATAGHGTALGVIRSLRDAGHSLTVFADETRPYLQGARLTAWELKEEGIPSYLITDNMAGWVMSSRKIHAVIVGADRIASNGDTANKIGTYPLAIIAKHHGVPFYVAATSKSMDFRIPDGSHIPIEMRKENEVTSFGFLKDATGKPLLNEGVLAPNGIKALNPSFDVTPASLISGIITERGIISPVTEENLRKTFS
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Q04RD6
B7MAV5
ASTE_ECO45
Succinylglutamate desuccinylase
Escherichia
MDNFLALTLTGKKPVITEREINGVRWRWLGDGVLELTPLTPPQGVLVISAGIHGNETAPVEMLDALLGAISHGEIPLRWRLLVILGNPPALKQGKRYCHSDMNRMFGGRWQLFAESGETCRARELEQCLEDFYDQGKESVRWHLDLHTAIRGSLHPQFGVLPQRDIPWDEKFLTWLGAAGLEALVFHQEPGGTFTHFSARHFGALACTLELGKALPFGQNDLRQFAVTASAIAALLSGESVGIVRTPPLRYRVVSQITRHSPSFEMHMANDTLNFMPFEKGTLLAQDGEERFTVTHDVEYVLFPNPLVALGLRAGLMLEKIS
Transforms N(2)-succinylglutamate into succinate and glutamate.
B7MAV5
P21988
FLA1_TREPH
Class B
Treponema
MIINHNMSAMFAQRTLGVTNNAIGKDME
Component of the core of the flagella.
P21988
Q90679
THYN1_CHICK
Thymocyte protein Thy28
Gallus
MPWPSRKRDKGAVADKKEPDAKIAKTEEETEDKEEEEKSTKPPAGSSKSGLKNWKKAKESDSGGEESKITYCHWLLKSEPESRLEKGVDVKFSIEDLKAQPNQTTFWEGVRNYQARNFLRAMKLGQQAFFYHSNCKEPGIVGIVKIVKEAYPDHTQFDQKDPHYDSSSRKENPKWSMVDVQFVRMTKRFIPLSEIKTHHLAHKADGGPLKNMMLFSRQRLSIQPLTQEEFDFVLSLEEEKPH
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
Q90679
P83572
ARALA_ARAEL
rRNA N-glycosidase
Aralia
ANFPTVSLNTVGITRQIPQDFMNAV
Toxic type II ribosome-inactivating protein (RIP). Induces apoptosis. Has cytotoxic activity against several human cancer cell lines. Is less cytotoxic to normal human cells.
P83572
B2IN14
DAPEL_STRPS
N-acetyldiaminopimelate deacetylase
Streptococcus
MLDLIQTRRALHQIPEIGLEEFKTQAYLLDVIEKLTTGKDFVQIRTWRTGILVYLQGSQPERTIGWRTDIDGLPIVEQTGLPFASQHQGRMHACGHDFHMTIALGCLERALEEQPKNNLLFLFQPAEENEAGGMLMYEDGAFGDWLPNQFYGLHVRPDLKVGQIATNTHTLFAGTCEVKIRFKGKGGHAAFPHEANDALVAASYFVTQVQSVVSRNVNPIEGAVVTFGVFQAGTTNNVITDTAFLHGTIRALTQDMSLLVQKRVKTVAEGVAAAFDMEVEVELKQGGYLPVENNPALARELMDFFDEKDGIELIDIEPAMTGEDFGYLLSKVDGVMFWLGIDSPYALHHPQMSPKEEVLAIGVAAVSSFLKKKAAE
Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate.
B2IN14
A0AVF1
IFT56_HUMAN
Tetratricopeptide repeat protein 26
Homo
MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEAELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIPGRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQSEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMIRIMKKWAKENRVSI
Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.
A0AVF1
O57864
CDC6_PYRHO
ORC1-type DNA replication protein
Pyrococcus
MNEGEQLHLDQLFEKLLKARKIFKNKEVLRHSYTPKDLPHRHEQIETLAQILVPVLKGETPSNIFVYGKTGTGKTVTVKFVTEELKKVSHKYNIPVDVIYINCEIVDTHYRVLANIVNHFKHETGIEVPLVGWPTDEVYAKLKQVIDMRERFVIIVLDEIDKLVKKSGDEVLYSLTRINTELKRAKVSVIGISNDLKFKEYLDPRVLSSLSEEEVVFPPYDANQLRDILMQRAEEAFYPGVLDDGVIPLCAALAAREHGDARKALDLLRVAGEIAEREGASKVTEKHVWKAQEKIEQDMMEEVIKTLPLQSKVLLYAIVLLDENGELPANTGEVYSVYRDLCEYLDLEPLTQRRISDLINELDMLGIINAKVVSKGRYGRTKEIRLNVTPYKIRNVFRYDYTIQPLLAISLKDSQRRLV
Involved in regulation of DNA replication.
O57864
A3D9I1
YACG_SHEB5
DNA gyrase inhibitor YacG
Shewanella
MPLTVKCPICKAPVEWVPQSAFKPFCSERCKLIDLGDWASEKHVIPVKAEFDPEAFDEFDLDEGDFFKE
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
A3D9I1
A1JML7
TUS_YERE8
DNA replication terminus site-binding protein
Yersinia
MNKYDLIERLNNRFTALEAGLQALHQQLEDLPLLAARVFSLPEIEKGTEHQPIMHIPVNATVGAAARDLAIQHYQRLFIHHQGQNVSSKAALRLPGVLCFSVTESQLATCQKSIQHINQLKTELEHIITVESGLPSEQRFEFVHTHLHGLITLNTYRTITPLINPSSVRFGWANKHIIKNVTREDVLAQLNKSLNAGRAVPPFSREQWVELISQEINDVQRLPEQARLKIKRPVKVQPIARVWYQEQQKQVQHPCPMPLIAFCQLQSAAELPKLGELTDYDANQIKHKYKPDAKPLQLLVPRLHLYLEI
Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence.
A1JML7
Q8TQR2
DNAK_METAC
Heat shock protein 70
Methanosarcina
MAKILGIDLGTTNSCMAVMEGGDAVVLPNAEGSRTTPSVVGFSKKGEKLVGQVAKRQAISNPENTVYSIKRHMGEANYKVTLNGKTYTPQEISAMILQKLKTEAEAYLGETIKQAVITVPAYFNDAQRQATKDAGSIAGLEVLRIINEPTAASLAYGLDKGDVDQKILVYDLGGGTFDVSILELGGGVFEVKSTSGDTHLGGDDFDQRVIDHLLAEFKKTEGIDLSKDKAILQRLKDAAEKAKIELSGVTVTNINLPFLTVGPDGEPKHMDIDLTRAQFQKMTEDLLEKTLVSMRRALSDSKLTPNDLDKVILVGGATRMPAVVELVENFTGKKPYKNINPDEAVAIGAAIQAGVLGGEVKDVLLLDVTPLTLGIETLGGIATPLIQRNTTIPTKKSQIFSTAADNQPSVEIHVLQGERGIASENKTLGRFTLDGIPPAPRGIPQIEVAFDIDANGILHVNAKDLGTGKEQSISIQKPGGLSDAEIERMVKDAELHAEEDKKRKEEVETRNNAEALINAAEKTIKEAGDVATEDQKSKVNAAIEDLKKALEGKDTEEVKAKTEALQEAVYPISTAMYQKAQQEAQQASGEAGSADARGPDETVVDADYEVVDDEKRK
Acts as a chaperone.
Q8TQR2
A0A0B5ABE6
INS1A_CONQU
Con-Ins Q1 A chain
Lividoconus
MTTSSYFLLVALGLLLYLCQSSFGTEHTCEPGASPHPQGKCRPELAEFHETMCEVEESLQGGTDDARKKRGRASLLRKRRGFLSMLKARAKRNEASPLPRAGRGIVCECCKNSCTYEEITEYCPPVTEGSG
This venom insulin facilitates prey capture by rapidly inducing hypoglycemic shock. Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In vivo, when applied to water, this peptide reduces overall locomotor activity of zebrafish larvae, observed as a significant decrease in the percentage of time spent swimming and movement frequency.
A0A0B5ABE6
P11983
TCPA_MOUSE
Tailless complex polypeptide 1B
Mus
MEGPLSVFGDRSTGEAVRSQNVMAAASIANIVKSSFGPVGLDKMLVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLKNADELVKQKIHPTSVISGYRLACKEAVRYINENLIINTDELGRDCLINAAKTSMSSKIIGINGDYFANMVVDAVLAVKYTDARGQPRYPVNSVNILKAHGRSQIESMLINGYALNCVVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQKILATGANVILTTGGIDDMYLKYFVEAGAMAVRRVLKRDLKHVAKASGASILSTLANLEGEETFEVTMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSLHDALCVVKRVLELKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPNTLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTIVKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGSYENAVHSGALDD
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
P11983
A4SUY4
RS11_POLAQ
30S ribosomal protein S11
Polynucleobacter
MAKQQSASAASQRARKKVKKNVADGIAHVHASFNNTIITITDRQGNALSWATSGGQGFKGSRKSTPFAAQVAAEVAGKAAVECGIKNLEVQIKGPGPGRESAVRALNSLGIKITEIQDVTPVPHNGCRPPKRRRI
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
A4SUY4
Q9NS56
TOPRS_HUMAN
Tumor suppressor p53-binding protein 3
Homo
MGSQPPLGSPLSREEGEAPPPAPASEGRRRSRRVRLRGSCRHRPSFLGCRELAASAPARPAPASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFVTPDRRFRYRTTLTRERNASVYSPSGPVNRRTTTPPDSGVLFEGLGISTRPRDVEIPQFMRQIAVRRPTTADERSLRKIQEQDIINFRRTLYRAGARVRNIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPAPSYEEGSHSDSSVITISPDEAETQELDINVATVSQAPWDDETPGPSYSSSEQVHVTMSSLLNTSDSSDEELVTGGATSQIQGVQTNDDLNNDSDDSSDNCVIVGFVKPLAERTPELVELSSDSEDLGSYEKMETVKTQEQEQSYSSGDSDVSRCSSPHSVLGKDEQINKGHCDSSTRIKSKKEEKRSTSLSSPRNLNSSVRGDRVYSPYNHRHRKRGRSRSSDSRSQSRSGHDQKNHRKHHGKKRMKSKRSRSRESSRPRGRRDKKRSRTRDSSWSRRSQTLSLSSESTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSRYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRVQSFSERTNARKKNNHSERKYYYYERHRSRSLSSNRSRTASTGTDRVRNEKPGGKRKYKTRHLEGTNEVAQPSREFASKAKDSHYQKSSSKLDGNYKNESDTFSDSRSSDRETKHKRRKRKTRSLSVEIVYEGKATDTTKHHKKKKKKHKKKHKKHHGDNASRSPVVITIDSDSDKDSEVKEDTECDNSGPQDPLQNEFLAPSLEPFETKDVVTIEAEFGVLDKECDIATLSNNLNNANKTVDNIPPLAASVEQTLDVREESTFVSDLENQPSNIVSLQTEPSRQLPSPRTSLMSVCLGRDCDMS
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
Q9NS56
P27589
PETD_SYNY3
17 kDa polypeptide
unclassified Synechocystis
MSIIKKPDLSDPDLRAKLAKGMGHNYYGEPAWPNDILYMFPICILGALGLIAGLAILDPAMIGEPADPFATPLEILPEWYLYPTFQILRILPNKLLGIAGMAAIPLGLMLVPFIESVNKFQNPFRRPIAMTVFLFGTAAALWLGAGATFPIDKSLTLGLF
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
P27589
Q8DGC6
CHLB_THEVB
Light-independent protochlorophyllide reductase subunit B
Thermosynechococcus
MKLAYWMYAGPAHIGTLRIASSFKNVHGIMHAPLGDDYFNVMRSMLERERDFTPVTASIVDRHVLARGSQEKVVDNIIRKDTEEHPDLIVLTPTCTSSILQEDLQNFVRRASLSTTADVLLADVNHYRVNELQAADRTLEQIVQFYIDKARRQGTLGTSKTPTPSVNIIGITTLGFHNQHDCRELKQLMADLGIQVNLVIPAAATVHDLQRLPQAWFNLVPYREIGGLTAQYLEREFGQPSVRITPMGVVETARCIRAIQGVLNAQGAGVNYEAFIEQQTREVSQAAWFSRSIDCQNLTGKKAVVFGDNTHAAAMTKILSREMGIHVVWAGTYCKYDADWFRAEVAGFCDEVLITDDHTVVGDAIARVEPAAIFGTQMERHVGKRLNIPCGVIAAPIHIQDFPVGYRPFLGYEGTNQLVDLIYNSFTLGMEDHLLEIFGGHDTKAVIHKGLSADSDLTWTAAGLAELNKIPGFVRGKVKRNTEKFAREQGISEITVEVLYAAKEAVGA
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
Q8DGC6
Q8DTE5
CAS2_STRMU
CRISPR-associated endoribonuclease Cas2
Streptococcus
MRMILMFDMPTDTAEERKAYRKFRKFLLSEGFIMHQFSVYSKLLLNNSANTAMIARLKENNPKKGNITLLTVTEKQFARMIYLNGERDTSIANSDSRLVFLGEAFPDET
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
Q8DTE5
Q07Y78
HLDE_SHEFN
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Shewanella
MKVSLPAFENARVLVIGDVMLDRYWVGPTGRISPEAPVPVVKINQIEDRPGGAANVALNIATLGGHVQLAGIVGQDETAQALTQGVKVFGVEPQWLTVADKPTITKLRVLSRNQQLIRLDFEEQFDKATSQALFAQSEAILDNVDVLVLSDYAKGAIDEPKDFIAKARAKGVKVLVDPKGHDFARYHGASLITPNMSEFEAVVGTVTSEDDLIEKAQKLIKLHDFEAILVTRSEKGMTLVSQNQPELHIPTVAREVHDVTGAGDTVISALATSIAAGASLAQACAIANTAAGVVVGKLGTSTVSRIELIQALALNHGESGFGVMTEDQLAYAMDQARLRGERIVMTNGCFDILHAGHVSYLQQAKALGDRLIVAVNDDSSVTRLKGPGRPVNPVDRRMAVLAGLASVDWVVPFTEDTPQRIITRLLPDSLVKGGDYKVEDIAGGAEVIAAGGKVEVLGFEDGVSTTAIIQNIMSQK
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Q07Y78
A7GD48
MURQ_CLOBL
N-acetylmuramic acid 6-phosphate lyase
Clostridium
MTNISLDKLVTESRNENTKDIDRVETLEMLKMINDEDKKVAEAVEKELIHIAKAVDKIGESFLNGGRLIYVGAGTSGRLGVLDASECPPTYGVSYDLVRGIIAGGESAMFKAREGAEDSKKLCIKDLKNINFGKNDILVGIAASGRTPYVIGGLEYANGIGATTISVTCNPESEMSKIANISIAPVVGPEAITGSTRMKAGTAQKMVLNMLSTGAMVKTGKVYGNLMVDLKATNEKLVERAKRIVMQATGSKREQVEKILKETNFDVKLSIFMIESSLDKIKAKEILDKNKGYIVEAIKEIS
Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate.
A7GD48
Q8WVJ2
NUDC2_HUMAN
NudC domain-containing protein 2
Homo
MSAPFEERSGVVPCGTPWGQWYQTLEEVFIEVQVPPGTRAQDIQCGLQSRHVALSVGGREILKGKLFDSTIADEGTWTLEDRKMVRIVLTKTKRDAANCWTSLLESEYAADPWVQDQMQRKLTLERFQKENPGFDFSGAEISGNYTKGGPDFSNLEK
May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone.
Q8WVJ2
Q6F880
TILS_ACIAD
tRNA(Ile)-lysidine synthetase
Acinetobacter
MRSALPTFDEIWQRKFRHRLLIQAQQFPADTVFLIGCSGGMDSMLLLHLMSELFPHKVRAIYIDHQLQSSSRAWGVFVQNFAQQSHIPFTIQPVIVDTGNLENQAREARYAAFESHLKSNEVLVLAHHQQDQTETVLLRLLSGSGVKGLGAMKEIEQKKNICCWRPMLSVSRQQIEHWVEHLKIPYIQDLTNFDTTYDRAWCRETVWPVLQKRFPKMQEAISRTSILMQDADEILHEVLQQDLNQCGDLNHLDLSRLQQLSLARQRQLLSFWMKGKAIYRPAFEMVERVQQEVICAKADAKAALHWNHHYYVRYQNILYRVEKNKYLQKDLVSNVVSTIELQMDASLQLASGVFQIQPMQMGLSPQLFEQPLQLLPRQGGEKIHLYGRVGHWPLKKAIQEAQILPWLRHTIQILALDNVMLGVFTPKGFWLAQSSYCEAGGWQPNLISDVNYLRVEQNS
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Q6F880
Q17ZB7
RS13_HELAH
30S ribosomal protein S13
Helicobacter
MARIAGVDLPKKKRVEYALTYIYGIGLKSSREILEAVGISFDKRVHELSEDEASSIAKKIQQSYLVEGDLRKKVQMDIKSLMDLGNYRGIRHRKGLPVRGQTTKNNARTRKGKKKTVGSK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
Q17ZB7
Q97QN5
NORM_STRPN
Multidrug-efflux transporter
Streptococcus
MYKTKCLREKLVLFLKIFFPILIYQFANYSASFVDTAMTGQYNTMDLAGVSMATSIWNPFFTFLTGIVSALVPIIGHHLGRGKKEEVASDFYQFIYLALGLSVVLLGMVLFLAPIILNHIGLEAAVAAVAVRYLWFLSIGIIPLLLFSVIRSLLDSLGLTKLSMYLMLLLLPLNSGFNYLLIYGAFGVPELGGAGAGLGTSLAYWVLLGISVLVLFKQEKLKALHLEKRIPLNMDKIKEGVRLGLPIGGTVFAEVAIFSVVGLIMAKFSPLIIASHQSAMNFSSLMYAFPMSISSAMAIVVSYEVGAKRFDDAKTYIGLGRWTALIFAAFTLTFLYIFRGNVASLYGNDPKFIDLTVRFLTYSLFFQLADTFAAPLQGILRGYKDTVIPFYLGLLGYWGVAIPVRTLFDSLTDFGAYSYWIGLIISLIVSGALYRWRLTVIMKRFESLAKSKC
Multidrug efflux pump.
Q97QN5
Q8YP49
DXR_NOSS1
2-C-methyl-D-erythritol 4-phosphate synthase
Nostoc
MVKSITLVGSTGSIGTQTLDIVSQYPDQFRIVGLAAGSNVEMLAEQIRQFRPQIAAISAAEKLPALQAAIKDLDPQPILLGGEAGVIEVARYGDAETVVTGIVGCAGLLPTIAAIEAGKDIALANKETLIAGGPVVLPLVEKHGVKLLPADSEHSAIFQCLQGVPKGGLKKILLTASGGAFRDWDVERLAEVTVSDALKHPNWSMGRKITVDSATLMNKGLEVIEAHFLFGLDYQDIEIVIHPQSIIHSLIELQDTSVLAQLGWPDMRLPLLYALSWPERIYTDWERLNLVKAGNLTFREPDHQKYPCMQLAYAAGRAGGSMPAVLNAANEQVVALFLDEKIKFLDIPRCIELVCDRHQNDNCANPSLDDILAADQWARQEVLTATKNLASQPQIISVN
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
Q8YP49
Q8CRP5
DDL_STAES
D-alanylalanine synthetase
Staphylococcus
MTKENICIVFGGKSAEHDVSILTAQNVLNAIDKERYQVDIIYITNDGEWKKKDNITQEIKNTDELVINDVETGEISQLLSKGSLGKSYDAVFPLLHGPNGEDGTIQGLFEVLDIPYVGNGVLAASSSMDKLVMKQLFEHRGLPQLPYISFLRSEYEKYENNIIKLVNDKLTYPVFVKPANLGSSVGISKCNNEEELKSGITEAFQFDRKLVIEQGINAREIEVAVLGNDYPETTWPGEVVKDVAFYDYKSKYKDGKIRLDIPADLDQDVQMTLRNMALEAFKATDCSGLVRADFFVTDDNQIYINETNAMPGFTAYSMYPNLWKNMGLSYPDLIAKLIDLAKERYEDKKKNKYKIDY
Cell wall formation.
Q8CRP5
Q9UBD6
RHCG_HUMAN
Tumor-related protein DRC2
Homo
MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRYPSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVVGVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPFWGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
Q9UBD6
A0A075B6H7
KV37_HUMAN
Probable non-functional immunoglobulin kappa variable 3-7
Homo
MEAPAQLLFLLLLWLPDTTREIVMTQSPPTLSLSPGERVTLSCRASQSVSSSYLTWYQQKPGQAPRLLIYGASTRATSIPARFSGSGSGTDFTLTISSLQPEDFAVYYCQQDYNLP
Probable non-functional open reading frame (ORF) of V region of the variable domain of immunoglobulin light chains . Non-functional ORF generally cannot participate in the synthesis of a productive immunoglobulin chain due to altered V-(D)-J or switch recombination and/or splicing site (at mRNA level) and/or conserved amino acid change (protein level) . Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens . The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen .
A0A075B6H7
Q14149
MORC3_HUMAN
Zinc finger CW-type coiled-coil domain protein 3
Homo
MAAQPPRGIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVINDHICLTFTDNGNGMTSDKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSGSMRLGKDAIVFTKNGESMSVGLLSQTYLEVIKAEHVVVPIVAFNKHRQMINLAESKASLAAILEHSLFSTEQKLLAELDAIIGKKGTRIIIWNLRSYKNATEFDFEKDKYDIRIPEDLDEITGKKGYKKQERMDQIAPESDYSLRAYCSILYLKPRMQIILRGQKVKTQLVSKSLAYIERDVYRPKFLSKTVRITFGFNCRNKDHYGIMMYHRNRLIKAYEKVGCQLRANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYRLTITALGEKLNDYWNEMKVKKNTEYPLNLPVEDIQKRPDQTWVQCDACLKWRKLPDGMDQLPEKWYCSNNPDPQFRNCEVPEEPEDEDLVHPTYEKTYKKTNKEKFRIRQPEMIPRINAELLFRPTALSTPSFSSPKESVPRRHLSEGTNSYATRLLNNHQVPPQSEPESNSLKRRLSTRSSILNAKNRRLSSQFENSVYKGDDDDEDVIILEENSTPKPAVDHDIDMKSEQSHVEQGGVQVEFVGDSEPCGQTGSTSTSSSRCDQGNTAATQTEVPSLVVKKEETVEDEIDVRNDAVILPSCVEAEAKIHETQETTDKSADDAGCQLQELRNQLLLVTEEKENYKRQCHMFTDQIKVLQQRILEMNDKYVKKETCHQSTETDAVFLLESINGKSESPDHMVSQYQQALEEIERLKKQCSALQHVKAECSQCSNNESKSEMDEMAVQLDDVFRQLDKCSIERDQYKSEVELLEMEKSQIRSQCEELKTEVEQLKSTNQQTATDVSTSSNIEESVNHMDGESLKLRSLRVNVGQLLAMIVPDLDLQQVNYDVDVVDEILGQVVEQMSEISST
(Microbial infection) May be required for influenza A transcription during viral infection .
Q14149
A0JPW5
HIP19_ARATH
Heavy metal-associated isoprenylated plant protein 19
Arabidopsis
MTKDKKKKDNVRYMDVEFNVSMHCNDCERKIARVISKFKGVETFVTDMINHKVVVRGKIDPNKLLKKLKKKTGKRVKIVVKEEKGEESSKENENVLEIDMESICLGDQSMFGFCDWEMEKFMVFSDENVKAICSIS
Heavy-metal-binding protein.
A0JPW5
A0A1D8PQN0
RS28B_CANAL
40S ribosomal protein S28B
Candida
MDAKTPVTLAKVIKVLGRTGSRGGVTQVRVEFLEDASRTIVRNVKGPVRENDILCLMESEREARRLR
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.
A0A1D8PQN0
Q8U158
RL24E_PYRFU
Large ribosomal subunit protein eL24
Pyrococcus
MARWNVCSYCGKPFEPGTGKMYVRNDGRVLFFCSRKCERYYFMGRNPRKLKWTKAYQEARLQRGGE
Binds to the 23S rRNA.
Q8U158
O66478
TATA2_AQUAE
Sec-independent protein translocase protein TatA 2
Aquifex
MFPGGISMTELIIILAVILLLFGAGRLPEAGRALGEGIRNFRKALSGETEVKEVKAEDVKTEERKEEKKEEKEKVEA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
O66478
Q2NTJ0
RUVC_SODGM
Holliday junction resolvase RuvC
Sodalis
MTVILGIDPGSRITGYGIVRQEGCKLTYLGSGCIRTKVDDLPARLKLIYAGVSEIITQFQPDCLAIEQVFMAKNADSALKLGQARGVAIVVAMNLDLPVFEYAARQVKQTVVGSGAAEKSQVQHMVRTLLKLPANPQADAADALAIAITHCHVSQNALRMGSGGLNLARGRLR
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
Q2NTJ0
A5W9N5
CBPM_PSEP1
Chaperone modulatory protein CbpM
Pseudomonas
MSSTLIVQLDMRTLCQEADVTAECVIEIVEHGIVEPSGRTPEDWLFDDQAPLVTKRAVKLHQELELEWEGVALALELLQEVQQLRSENNMLKQRLGRFIQM
Interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ.
A5W9N5
Q57849
NK_METJA
Guanosine-inosine kinase
Methanocaldococcus
MGGKMEKITCVGHTALDYIFNVEKFPEPNTSIQIPSARKYYGGAAANTAVGIKKLGVNSELLSCVGYDFKNSGYERYLKNLDINISKLYYSEEEETPKAWIFTDKDNNQITFFLWGAAKHYKELNPPNFNTEIVHIATGDPEFNLKCAKKAYGNNLVSFDPGQDLPQYSKEMLLEIIEHTNFLFMNKHEFERASNLLNFEIDDYLERVDALIVTKGSKGSVIYTKDKKIEIPCIKAGKVIDPTGAGDSYRAGFLSAYVKGYDLEKCGLIGAATASFVVEAKGCQTNLPTWDKVVERLEKHRI
Catalyzes the phosphorylation of a wide range of nucleosides to yield nucleoside monophosphates. Shows the highest activity for inosine, guanosine and cytidine, but very poor kinase activity with adenosine, thymidine, uridine and xanthosine. ATP is the best phosphate donor, but can also use ITP and GTP. Shows extremely low activity with fructose-6-phosphate.
Q57849
Q7ZUH5
RM14_DANRE
39S ribosomal protein L14, mitochondrial
Danio
MALSLSGLILPKLMQQRAFSVSSAVSAIQKLTRVRVVDNSTLGNAHHHRPPKVIHVYNKNGVGKVGDRVLLAIKGQKKKAIIVGHKMPGARMTPRFDSNNVVLIEDNGNPTGTRIKAPLPTHLRKLEGEYSKLLAIAQRFV
May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation.
Q7ZUH5
Q93HU4
NHAP_APHHA
Sodium/proton antiporter ApNhaP
Aphanothece
MTIEAAMGEEAIKENLEQFLIVLSVSLGVATLSQISSFFRQIPYTLLLVIVGLGLAFVDIRLVNLSPELILEIFLPPLLFEAAWNIRWRNLKKNLFPVVLLAIIGVVISVVGIGFSLNYFSGLSLPIALLVGAILAATDPVSVIALFRELGVGERLTVLMEGESLFNDGVAVVAFSLLVGIPLGTQEFSVTNTLIQFVTLQGIGIGCGGVIGFGISYLTQRFDLPLVEQSLTLVSAYGTYLITEELGGSGVIGVVTVGLILGNFGSRIGMNPRTRLLVSEFWEFIAFFVNSIVFLLIGDQINIRGLADNGQLILITIIALVIIRAISIYGLGTISNLITKQDISWQEETVLWWGGLRGSVSIALALSVPVMLDGRQDIIEAVFGVVLFTLLVQGLTMQTVIEKLGLIGDRAQRRTYSELIARRSALERVLAHLNAVPPSPSIRMKSLKTTKEASKGQLESRQTKKLRSYNNSYPQLRSLEQEQLRELTFKVEADTYAELIRAGKLNNNLSPLLQEVLAKPE
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. Shows also high Ca(2+)/H(+) antiporter activity at alkaline pH. Does not catalyze exchange between Li(+) and H(+).
Q93HU4
B7GUP8
FMT_BIFLS
Methionyl-tRNA formyltransferase
Bifidobacterium
MLKLVFAGTPDVAVPSLKAFATDPRFDVVGVITRPDAPTGRGRKLTPSPVKAKALELGLPVIDLKPRSPEFMEALNDLHADIAAVIAYGNILPKNVLDAVPMGWYNLHFSNLPKWRGAAPAQRAIWAGDPTTGADVFKVGEGLDDGPIVASLTIELTGRETSGELLDRLAEEGAPMYVDALAAVGEGTATFTAQPAECLEYAHKITVEDARISWTDEAGAIDRQIRACTPHPGAWTELFAEGPIADNDGSTAKSLTLHILAAQPADQSNPNTPADLKPGELKVGKKNVWVGTGSTPLELIQVKAQGKKAMRAADWARGARLSPAACVR
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
B7GUP8
Q8ZDH1
TATE_YERPE
Probable Sec-independent protein translocase protein TatE
Yersinia
MEGLSITKLLVVGILIVLLFGTSKLRTLGADLGAALKGFKKAMRNDDEVSTSVLGETKMSAETKTVAETKAASDSQAAASVERKD
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA.
Q8ZDH1
Q0IIM8
TBC8B_HUMAN
null
Homo
MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIRGLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQTYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSLTSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCYWCLGCPVLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKGDELSKEELLYFSQLHVSKPANEKEAESAKHSPEKGKGKIDIQAYLSQWQDELFKKEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKLHSPTSSAKGFSGTVCGSGGPSEEKTGSHLEKDPCSFREEPQWSFAFEQILASLLNEPALVRFFEKPIDVKAKLENARISQLRSRTKM
Involved in vesicular recycling, probably as a RAB11B GTPase-activating protein.
Q0IIM8
C8NA81
METAS_CARH6
Homoserine transsuccinylase
Cardiobacterium
MPLVAHRELESLDRLRAEGQEILDVRRASQQDIRELHIGLLNLMPDGALKATERQFLRLIGNSNRIAQFYVHIFTVPGVPRSADMQAYIDSHYENFDDLAHDGLDAIIFTGTNPLHADLAQEAYWPHVQRVFDWADKNVTSVLCSCLASHLALQHFHGIARKRRDEKLFGVFSHRVLDRSHPMLANINTRFDMPHSRWNGISAAQLEARGLPVLVAGEESGVAMASSPDGFRQIYFQGHPEYDRSSLLKEFRRDLALYQDGKLPQPPKLPTHYFTPAGQRLIRDYIESGRPISDFPEAQLADEVDVTWRDTAKALFANWLGLVYQLTHKERHLQYMDGIDPADPLGRLRR
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
C8NA81
P22136
AEP2_YEAST
ATPase expression protein 2, mitochondrial
Saccharomyces
MWINRLVKHPSYSVLRFYTKRLCTVSVKSLREFGVLPNSTICHSVYPRRTYVMGRAVINDILIKKSYSTHTVCAIDRSKDENNGSAYDKFEAKGIPIDVHTLKRIISSSGMDESEFSKSISYLFAKTVDPEPKDVLSLEDLSFLLSKLYTQRFQIRRICRDINAKYSEFWFKLFSLYAEKVDAKRNQVNLRNTKLDACEIFDANLMIKNFIELGQLGKAQKILSFILDRNPDILLSPKNADISTIVHFLQLRCGALAPYWKIPDNSEQKQGFLRKMVRLGAKNTSIRLSSTYKAMDHQTLLKIADLALQEKKLLNSEDLLSTLIQSFGHLGQTQILERCIEHIWQISPQEFPSHVVIKHRGCYPSSKILVSILVSFYFNDHDLHRGLSILDSFIKHYPDVKLDALFWRRLFQLSHFAWTPANDKKATSVVRCWHLMKQWYASKRLRPSVDYETLRQLYDIMKKTGNFPLGIDVLRSFKPGIERTRAENAGKVNNIIIKYQKCIIKELVNRGRFSAVREFIDSYGFDRKMTKDLNIFCANRMFLRSKKMKNKIENKKEREKVRLDSFDDDEDDGMIIGSLW
Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9.
P22136
B1HW99
RNH3_LYSSC
Ribonuclease HIII
Lysinibacillus
MSNIVLSISTNIQKEVMAYYAANYIERKAAGVIFAAKLPDTSITMYKSGKLMFQGGGAEREAARWGTIEKTPNSKSAIIGAKGDTLPDQFALMSVLGSDETGTGDYFGPMTVAAVYVPSSKIELINELGVKDSKMLSDDYMRKIAPDLRAACVHSVLILRNEKYNSLQAKGYSQGKMKAMMHNKALHNTLAKMAPETPEYILIDQFAERGVYYNYLKNEREIVQESVYFSTKAEQLHVAVATASILARAAFLKEMDRLSDIAGLELMKGASNKVDVQAARIWRKQGEEFLRSITKWHFANTEKARKMI
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
B1HW99
Q2SDI1
NADK_HAHCH
ATP-dependent NAD kinase
Hahella
MEQFRNIGLLGRMGSVQVVETLKRLKNYLVGEGYAVILEEATAAVLPGHNVQVSSKKMLGEICDLVIVVGGDGSLLGAARALAGCNVPVLGVNRGRLGFLTDITPTEMEPQLAEVLSGKYVEESRFLLDAYVKRNGEPVGYGCGLNDIVLHPGKSTRMIGFDLYIEGQFVNSQRSDGLIVSTPTGSTAYALSAGGPIMHPRLDAIVLVPMFPHTLSSRPIVVDGNSEIKIIIGDYNQTYPHVSCDGQTHVTCAPGDTVTICKKPQKLRLIHPMNHNFYQICRDKLGWSSSRDQGGQ
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Q2SDI1
Q3ZC48
DRAM2_BOVIN
Transmembrane protein 77
Bos
MWWFQQGLSFLPSALVIWTAAAFIFSYITAITLHHVDPVLPYISDTGTVAPEKCLFGAMLNIAAVLCVATIYVRYKQVHALNPEENRIIRLNKAGLVLGLLSCLGLSLVANFQKTTFFAVHVCGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSLLYNGSFGADIVQKLHWNPEDKGYVLHMITTAAEWSMSLSFFGFFLTYIRDFQKISLRVEATLHGLTLYDTAPCPVNNERTWLLSRDV
Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1.
Q3ZC48
B0JM93
PETD_MICAN
17 kDa polypeptide
Microcystis
MSTLKKPDLSDPALRAKLAKGMGHNYYGEPAWPNDLLYVFPVVIFGTIGLCTGLAIMDPTMIGEPADPFATPLEILPEWYLYPVFQILRILPNKLLGIACMAGVPLGLMLVPFIESVNKFQNPFRRPVATAIFLFGTVVTIWLGIGATFPIDISLTLGLF
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
B0JM93
Q8RU33
VA0D_ORYSJ
Vacuolar proton pump subunit d
Oryza sativa
MYGWEMLSFNIHDGFLEAIVRGNRSGLLTAADYNNLCQCENLDDVKMHLTATEYGPYLQNEPSPLHTTTIVEKCTLKLVDEYKHMMCQATEPLSTFLQYITYGHMIDNVVLIVTGTLHERDVNELLEKCHPLGMFDSIASLAVAQNMRELYRLVLVDTPLAPYFSECITSEDLDDMNIEIMRNTLYKAYLEDFYKFCEKLGGATAEIMCDLLSFEADRRAVNITINSIGTELTRDDRRKLYSNFGLLYPYGHEELAVCEDVDQVRGVMEKYPPYQAIFAKISYGESQMLDKAFYEEEVRRLCLSFEQQFHYAVFFAYIRLREQEIRNLMWISECVAQNQKNRVHDSVVFIF
Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.
Q8RU33
Q8K402
TBX22_MOUSE
T-box transcription factor TBX22
Mus
MALSSRAHAFSVEALMGRPSKRKAQDPREEMQPELQEEQFVEEGEEILRSPSRDSQQPEKRLKAESSKTVFSCSDESNSQESLQEESVIQVELQGSDLWKRFHDIGTEMIITKAGRRMFPSVRIKVKGMDPVKQYYVILDVVPVDSKRYRYVYHSSQWMVAGNTDHSCITPRFYVHPDSPCSGENWMRQIISFDRVKLTNNEMDDKGHIILQSMHKYNPRVHVVEQDSRIDLSLIESFPTEGVKTFSFKETEFTTVTAYQNQQITKLKIDRNPFAKGFRDPGRNRGVLDGFLETYPWMPSFSMDFKTFVTDTQSGSSGSSPVTSSGGAPSPLNSLLSPSCSPPMVYIPPSSFGMTYPDAYLHSVNIPFCYRICPTNNWRSQPFVLPTPERLPSFIIPQTLPPLMMEVPVVSSRGIINPNSGLHEDCNGQCLQASHSANQMLYGLQNPGNIFHPNAIAQEAISYPFHPPNGCYRYTISMPPRLENVASHLSENGTSQISFTEGSCDHSHWYPAINHYL
Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.
Q8K402
Q1QJ95
DCUP_NITHX
Uroporphyrinogen decarboxylase
Nitrobacter
MAQDSTIKPFLEVLSGRRQAVPPIWMMRQAGRYLPEYRELRAKAGGFLDLCFTPEFAAEVTLQPIRRFAFDAAIIFSDILVIPYALGRSVRFEVGEGPRLDPLDTPDMAATLSREADMTKLEPVFEALRRVRRELDSKTALIGFCGAPWTVATYMVAGRGTPDQAPARMMAYRHPEAFAKIIDVLVENSVRYLLGQLKAGADVLQIFDTWAGVLPPREFARWSIEPTRRIVEGVRKIVPDAKIIGFPRGAGALLPSYIEATGVDAVSIDWAAEPSLVREKVQSRVAVQGNLDPLALIAGGAALDRAVDDVLANFAGGRLIFNLGHGIQPETPIPHVEQMIRRVRGSGLRE
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Q1QJ95
A5EVY3
LUXS_DICNV
Autoinducer-2 production protein LuxS
Dichelobacter
MERKHMNVASFNLDHNAVKAPYVRLADKKIGSHGDVIYKYDIRVCQPNREQMLMPALHSLEHLLAELMRNHSDKILDISPMGCQTGFYISLLNEPDYQVMLHLLETTLNDILAAEAVPACCEEQCGFAANHSLSGAQEIARYLLAHRNKWEQVF
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
A5EVY3
P28381
RBL_BARCA
Ribulose bisphosphate carboxylase large chain
Barnadesia
MSPQTETKASVGFKAGVKDYKLTYYTPDYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYGIEPVLGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYVKTFQGPPHGIQVDRDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGTCEEMMKRAVFARELAVPIVMHDYLTGGCNATTSLAHYCRDNGLLLHIQRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGEREITLGFVDLLRDDFIKKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGPVANRVALEACVQARNDGRDLAIHGNEIIREACKWSPELAAACEVWKEIKFEFPALDTFV
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
P28381
Q6RYS9
DOPR3_CAEEL
Dopamine D2-like receptor dop-3
Caenorhabditis
MLAGQHHVTDIESPLMVVLWRVAAGVFLPLVPTMAVFGNVLVIMSVFRERSLQTVTNMLIVSLAVSDFMVAIGVMSFGVYYEWNDFKWGLGSFFCHVYQALDVACSTASILNLLAISLDRYIAIGHPISYAQYGARGGRAMISITIVWGVSVAVALPLLLGVNPMEENDLQECELANPYFNMISSIFSFFIPCIAMIILYTIIFRRLRQRERARSLRQAQRSENDKISSALLGGAQIARQMGKHFKNRTDQILLEISFQTSSFPTMSESSEDASTISPMINSFNNFLPKKTPYPSTSIPAIPECGSMPNLTIIERPEAEKEKEISIMDLRDTVEMLDDKYSSAILTSFQTSRSFGEELEEILPFIDGSNSVKHSREQLHTTRSNTSTTRLLDVKPELRSISVPSIQDEKKLSQKSNDLPFSHQNGTHKQKLLPNPGILMKSKSTTLLKTNGYMDTDSLNRNSHKKSLADLLANDEFSFSDSMRVYKNRLFKSLSRATSGWNKPRPSRHMVKKATKQMRREHKATVTLAVVLAVFLFCWLPFFVLHLSNSICLIIDENSACVGFLPLYLATWLGYLNSSLNPLIYTVFDQRFRNAFRNILSCGIFKKR
G-protein coupled receptor which binds to the neurotransmitter dopamine with high affinity leading to the activation of an associated G-protein and downstream signaling pathways . Couples to G-proteins to inhibit adenylate cyclase (AC) activity and cAMP production . Antagonizes the D1-like dopamine receptor dop-1 to negatively regulate the rate of locomotion . In GABAergic, RIC, and SIA neurons, antagonizes the function of dop-1 to play a role in behavioral plasticity and regulate the decision-making process when conflicting alternatives are present . Antagonizes octopamine signaling in response to food by promoting the dopamine-mediated suppression of crh-1/CREB1 transcription factor activation in cholinergic SIA neurons . This is most likely in association with the G(o)-alpha G-protein subunit goa-1 . Promotes male mating behavior by antagonizing acetylcholine signaling to control the protrusion of copulatory spicules from the tail of males during hermaphrodite vulval location .
Q6RYS9
Q1GAQ0
EFTU_LACDA
Elongation factor Tu
Lactobacillus
MAEKEHYVRTKPHVNIGTIGHVDHGKTTLTAAITTVLAKKGLAQAEDYSQIDAAPEEKERGITINTAHVEYETEKRHYAHMDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVNSIVVFLNKCDLVDDPELIDLVEMEVRDLLSEYGYPGDDVPVVRGSALKALEGDEEAQKKIEELMDVVDEYIPTPERETDKPFLMPVEDVFTITGRGTVASGRIDRGTVKVGDSVEIVGLVEKVLTSVVTGLEMFHKTLDLGEAGDNVGVLLRGVDRDQIVRGQVLAAPGSIKTHKTFKGQVYILSKDEGGRHTPFFSDYRPQFYFHTTDITGEIELPEGTEMVMPGDNTEFSVTLIKPAAIEVGTKFTIREGGRTVGAGQVTEIDD
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q1GAQ0
A1S3S8
TSAD_SHEAM
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Shewanella
MRVLGIETSCDETGIAIYDEEKGLMAHTLYSQVKLHADYGGVVPELASRDHVRKIIPLIREALKNADTRIEDLDGICYTKGPGLIGALLVGACVGRSLAFSWNLPAVGVHHMEGHLLAPMLEDEVPEFPFVALLVSGGHSMLVKVDGIGQYEVLGESIDDAAGEAFDKTAKLMGLDYPGGPRLAKLAASGQPANYKFPRPMTDRPGLDFSFSGLKTFVANTIAAEPDDEQTRANIARAFEEAVVDTLSIKCRRALEQTGYKRLVIAGGVSANVRLRAGLAELMEKLGGKVYYPRGEFCTDNGAMIAYAGLQRLKAGQLEDLAVKGQPRWPLDTLLPV
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
A1S3S8
P29238
LUXA2_PHOLE
Bacterial luciferase alpha chain
Photobacterium
MKISNICFSYQPPGESHQEVMERFIRLGVASEELNFDGFYTLEHHFTEFGITGNLYIACANILGRTKRIQVGTMGIVLPTEHPARHVESLLVLDQLSKGRFNYGTVRGLYHKDFRVFGTSQEDSRKTAENFYSMILDASKTGVLHTDGEVVEFPDVNVYPEAYSKKQPTCMTAESSETITYLAERGLPMVLSWIIPVSEKVSQMELYNEVAAEHGHDINNIEHILTFICSVNEDGEKADSVCRNFLENWYDSYKNATNIFNDSNQTRGYDYLKAQWREWVMKGLADPRRRLDYSNELNPVGTPERCIEIIQSNIDATGIKHITVGFEANGSEQEIRESMELFMEKVAPHLKDPQ
Light-emitting reaction in luminous bacteria.
P29238
D6R3B6
PAMT_CAPFR
Putative aminotransferase
Capsicum
MANITNEFMGHDMLAPFTAGWQSDMEPLVIEKSKGSYVYDINGKKYLDTLSGLWCATLGGSETRLVEAANKQLNTLPFYHSFWNRTTKPSLDLAKELLNMFTANKMAKVFFTNSGSEANDTQVKLVWYYNNALGRPQKKKIIARAKAYHGSTYISAGLSGLPPMHQKFDLPPPFVLHTECPHYWAYHLPGETEEEFSTRLANNLESLILNEGPETVAAFIAEPVLGAAGVILPPATYFDKVQAILRKHDILFIADEVVCGFGRLGTMFGSDKYNIKPDLVSVAKALSSGYMPIAAVLVSQKISSVILSESNKIGAFCHGFTYSGHPVACAVALEALKIYKERNITEVVNKISQKFQEGLKAFADSPIIGEIRGTGLALSTEFVDNKSPNDPFPYEWAVGTYFGAQCAKYGMLVSSTGDHVNMAPPFTLSLEELDELIRIYGKALKDTEKRVEELKSQKK
Participates in the biosynthesis of capsaicinoids in pungent cultivars of Capsicum frutescens . Capsaicinoids, the alkaloids responsible for the heat or pungency of chili pepper, are synthesized from phenylpropanoid intermediates in the placental tissue of chili peper fruit (Probable). Can transfer an amine from alanine to vanillin, forming vanillylamine and pyruvate .
D6R3B6
Q1QUS6
LOLA_CHRSD
Outer-membrane lipoprotein carrier protein
Chromohalobacter
MRAFKWALAIGATLALPLTAQAQTGGAERLAALLESVTSYSADFDQQILDGGGQRLQEAEGHMWLSRPGKFHWEVEAPYRQVVVSDGDKVYLYDPDLEQVSVRPLDTRVTHTPALLLSGSADALTENYAVESRQGDDEETFTLTPKSPDTLFESLQLTFENERLEGLQMEDSTGQRTAIAFDDIEVNGDIDASRFTFEIPEGADVIREGG
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
Q1QUS6
Q1QYX8
TSAD_CHRSD
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Chromohalobacter
MRVLGIETSCDETGVAIYDTERGLIADALHSQMAMHAEFGGVVPELASRDHTRKLLPLIRQVLDDAELRGDQLDAIAYTAGPGLVGALMVGASTAHGLARAWDIPALGVHHMEGHLLAPMLEAAPPDFPFVALLVSGGHTQLVEVHGLGRYRLLGESVDDAAGEAFDKAAKMLELPYPGGPHVAQLAERGDPTRFRFPRPMTDRPGLDFSFSGLKTHTLTTANQLKAAGPLSDQDRADIARAFEEAVVDTLVIKCRRALDTTGLKRLVVAGGVSANHRLRERLDRETAKRQAQAFYPRGRFCTDNGAMIAYVGAQRLLAGERDDATMQATPRWPLASLTPPAA
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Q1QYX8
Q63467
TFF1_RAT
Protein pS2
Rattus
MEHKVTCVLAMVLMLALSSLAQNQEETCAVIPRERINCGFPGVTAQQCKEKGCCFDDSVRGFPWCFRPLVIENQQEEECPF
Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents.
Q63467
P55291
CAD15_HUMAN
Muscle cadherin
Homo
MDAAFLLVLGLLAQSLCLSLGVPGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMYGHPCGLEYGARWDHQAREGLSPGALLPRHRGRTA
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
P55291
C1FNC6
GREA_CLOBJ
Transcript cleavage factor GreA
Clostridium
MSEAKKYVMTYEGVKKLEEELEFLKTVKRKEITEKIKVALSFGDLSENSEYDEAKNEQAFVEGRIIQLENMLKNASIVDENEVPKDIVSVGSIVKVKDYEFDEEVEYIIVGSAEADPMNNKISNESPVGHGLIGKKVGDIIEVTVPDGVSKYEILEVNRA
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
C1FNC6
Q03308
VPS16_YEAST
Vacuolar protein-targeting protein 16
Saccharomyces
MKNPSFDWERLKDVFYRSRAIGELKWPTQYEEFKCALSLTVIAVEIQDFIQVYNYFGQLLGKINLQRIHEDIIKFEFDKDEKLILVTKSSIKIVKGWSPLTIESVPLQDPTIDTIWDYHNGIMLLAKSRDIYKLNGNEWELLYENKDKKYNLLTKNHWSCNDDSIILLDVDHVYQVSTSNGALLKLITDSSWHKVTISSRGFICLYNMKDNKLQIFRDPARILMEHNLDSTPDDICWCGNDTVACSFEDEIKLYGPDGLYVTFWYPFTVTNLRAEVDGLKVITTEKIYFLSRVQPQTSNIFRIGSTEPGAMLVDSFSLLEDHAPKAIEILKNFVLEKGVLDCIAAAIDEFEPKLQKMLLNAASYGKASLQYKSFDASIFVNACNTIKLLNCFRSFGIFLTVEEYRCISLKGVIDRLLKYHRYYECIQICKLANERFLLGYVFTEWAKDKIKGSPDMEDDELLDKIKSRLSVIDMTDTLQMVAVAKVAYLEGRFQLSRNLALLEKNEEARIEQLYNLDDDSIALKECIKVQNYSLTISLLIALSKKLTNSQLTKLLIIDMFNNPLYLYYMRMDKAYLYDFYRQTDRFIDLAHVLLQQGKEQQSLHSFLPQIKDLYSQVQNSEVVNNTIEQLQRQEKLWIYQESLGKRFAISFTNMTLDQTLSKLIETGQDKQVKEIVKKFKISEKKLYHLKCKTLVEAKKFDELLQFAQSRKSPIGYMPFYTYLKSRGHMDKASPYVNMIPGLSYQEKKKLYVECRGFRDAIQLAGKEKDIPGLKEIYNIIPPNEPELKALANETMSRI
Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. Required for growth at elevated temperatures. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is an effector for the vacuolar Rab GTPase YPT7 and is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion.
Q03308
Q69YH5
CDCA2_HUMAN
Recruits PP1 onto mitotic chromatin at anaphase protein
Homo
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
Q69YH5
P53559
BIOW_BACSU
Pimeloyl-CoA synthase
Bacillus
MMQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEGVSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWALHSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
P53559