accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
B8FW28
RL25_DESHD
General stress protein CTC
Desulfitobacterium
MSETAIQAVERKEKPKEVRSKGFVPGVIYGKGMDSISVKFDEKRLNKALQGRSQKAKISVQVAGETKQCFVGEIQKDITSGKTIHISMQVVEDDQVVKMKVPITFGGSEALSERKLIVLPYFSELELTGPSADIPEYVAVDVADKSLGDKITVADFMVSPSVSVLDDPEKIIAAITGAR
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
B8FW28
Q4A5I9
RS11_MYCS5
30S ribosomal protein S11
Mycoplasmopsis
MARKAKKKNISSGVAHIHSSNQNTIITFTDEKGNVIAWSSSGKVGFKGTKKKTSFAASEAAKDAAQMAKEHGISQVRVEMKGLGSGKDSARKQIEVWGIKVTEIKDVTPIPHNGTRPPKRVLKRLRLKK
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Q4A5I9
B1I1H6
RECF_DESAP
DNA replication and repair protein RecF
Candidatus Desulforudis
MRLTRIKAGNFRNFQHLDVQPAAGLNIVRGRNAQGKTNFIEAVFFALRGHSFRSLRDRELVTWGQESAFVEAELEGKDGRTRVRAELNPAGKKIVWAGEPVGKAELAVRLGTVLFTPDDLSLIKGGPRERRRFLDLELGIFVPGYLTALQLYRRALEQRNHLLRMGGGRRYSELLDLWTDEVCKYGMMLLSGRLEILKEFAPLACRLFGAWAGEELAVRYRSSVGLSNGVRTPGAGDLRETLAAVRQDEIRAGQTQAGPHLDDLAFMVNGKEGRPFASQGQQRSVVLALKLAQVFLWKRHTGEAPVVLLDDLLFEFDRERRDKVLETLQNDVQVFITTGERVLSGSRVFCVHSGNIQEES
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
B1I1H6
Q5SQY2
BOD1_MOUSE
Protein FAM44B
Mus
MADGAGAGAAGQASGPSGGSSGAGGPVNPASLPPGDPQLIALIVEQLKSRGLFDSFRRDCLADVDTKPAYQNLRQKVDNFVSTHLDKQEWNPAMNKNQLRNGLRQSVVQSGMLEAGVDRIISQVVDPKLNHIFRPQIERAIHEFLAAQKKEAVPAPPPEPESQDPPAPSQDAS
Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles.
Q5SQY2
Q5P7T7
RL13_AROAE
50S ribosomal protein L13
Aromatoleum
MKTFSAKPHEVKRDWFVVDASDKVLGRLAAEVARRLRGKHKAIYTPHVDTGDFIVVVNVEKLRVTGNKALDKKYYRHTGYPGGIYETNFTKLQQRFPERVLEKAVKGMLPKGPLGYAMLKKLKCYAGGEHPHSAQQPQVLEI
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Q5P7T7
A0KAV9
LIPB_BURCH
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Burkholderia cepacia complex
MSVSPVSIVSTPVAVSASPAGAPDQPVQPVTVRWRGREAYEASFDAMRAFTDTRTADTGDEIWVVEHPPVYTLGQAGDPAHLLVADSGVPLVKVDRGGQITYHGPGQIVVYLLLDLRRRKLMVRTLVTKIEEAVIETLAAYNLASVRKAGAPGIYVASGVHEGAKIAALGLKIRNGCSYHGLSLNVKMDLRPFLAINPCGYAGLETVDMASLEVAADWNDVAHTLVGRLIANLDGASAAADKPHALEQSND
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
A0KAV9
A7ZCA7
YBEY_CAMC1
Endoribonuclease YbeY
Campylobacter
MILCEESYPEILDQICSYLTPGEVELLFINKDEMRELNRSERGIDKTTDVLSFPLELVIHAPLGSIVINKDMVKEKAAELNHSEDAETALLFTHGLLHILGYDHEKDDGQMREKECEVIAKFNLPKSLIVRSEDVRLIDLINKKG
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
A7ZCA7
A1JJS9
CYSD_YERE8
Sulfate adenylate transferase
Yersinia
MDEKRLTHLRQLEAESIHIIREVAAEFGNPVMLYSIGKDSSVMLHLARKAFFPGNLPFPLLHVDTGWKFREMYEFRDHTAKAFGCELLVHRNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTELDIWQYIFLEKIDIVPLYLAKPRPVVERDGMLLMVDDDRIDLQPGEVITQKMVRFRTLGCWPLTGAVESEAQTLPAIIEEMLISTTSERQGRMIDRDQSGSMELKKRQGYF
With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
A1JJS9
Q54YY1
SCAI_DICDI
Protein SCAI homolog
Dictyostelium
MEITTKSSTTTDDLNNNNNKTVTPIKSENSATGHTSPPNNSTTTTTSSTSAQPITVLPTEIIKTFEHLLRKSQRLFIGLRDLPQFGRQWQPFFQKTFELYTKLWKFQQQYRSILEDKSKYGLKRCEIGEIASKIGQLYYHYYLRTSDTNYLNESYIFYEAIRLRSYFKDVSLDKTPDMMVKQLRYYARFIVVCLLLNKKKVVFDLIEELLKHVNDYTKIYKPSDAQEWSLVLQEIFSFLQADQCATFSDTNQSPSLTNSGNIINNNSNSNNNNGEHTNNTVQSHRLNHLNCPSPPFPLESTQILQQAILVGSQQNQIKFSEITLDMFRMTQSLEYEPMSEAKENDMKLKQQLTALQQQQQQQAAEAKEKNNGTDQQNTTIPSQPLQQHLHHQQQQQQNGNGSGIKKRNPHKYLLYRPTISQILLFLSYSFKELGDNKAMLLYICADGFTNEDNHVNQHIQPPPSIQQETVPSLIDDSNTNIPITTTATATNPLYNKLFTKGLTLNMQKPSQAINSPTVNNNNNNTTTNVTVPTTTTTATNVTAQTTTTTTTTNSTSTSTTSNIPIYKYNEAPFNTKVESLYPMDLLPFCRKPFFLIVNSQSSDIFNELPTFNQPFVSLLSPQSIPKKLVSNLKCGNLFTFFLHDPISAFCDISCGNKIPSKTFNNISLLAQNSLEIISKLLFECVDLHPSFSFFLLDDFLRSFIIRFIFCHATFYLHKEFQDNIYQVKSNPPLPKSLLYNQSILKSIHQLVSELDVSDQFLGLNENRLVIHEN
May function as a transcriptional cofactor with a repressor activity.
Q54YY1
I3V6B1
C80BX_PAPSO
Cytochrome P450 80BX
Papaver
MEIVTVALIAIVFTTFLYLIVRESSPNGLPPGPKPWPIVGNLLQLGEKPHSQFAQLAETYGDLFTLKLGTQTVVVASTPLAASEVLKAHDRTLCGRYVFQSFRVKNHVENSIVWNECNETWKKLRKVCRTQLFTQKMIENQAEVREIKTMEMVKYLKKNEGIEVKIVEVIFGTLVNMFGNLIFSQDIFKLGDESSGSLEMKQHIWRMLELGNSANPGDYVPLLGSLDLFGQRKDVADCLQGVYGVWGAMLKERRIAKRQINGDTKNDFVDVLLDSGLDDQQINSLLLDMFSAGTETTASTIEWALTELTKNPQVTADIRSELLSVVGKRAVKESDILNLPYLQAFVKETLRLHPPTPLLIPRRALETCQVLNYTIPKECQIMVNAWGIGRDPKTWTDPLKFSPDRFLNSSIDFKGNDFELIPFGAGRRICPGVPPGNSVY
Involved in the biosynthesis of benzylisoquinoline alkaloids. Probably involved in papaverine biosynthesis since its transcripts are abundant only in cultivars with substantial papaverine accumulation. May catalyze the 3'-hydroxylation of (S)-coclaurine.
I3V6B1
Q72JP3
RUVC_THET2
Holliday junction resolvase RuvC
Thermus
MVVAGIDPGITHLGLGVVAVEGKGALKARLLHGEVVKTSPQEPAKERVGRIHARVLEVLHRFRPEAVAVEEQFFYRQNELAYKVGWALGAVLVAAFEAGVPVYAYGPMQVKQALAGHGHAAKEEVALMVRGILGLKEAPRPSHLADALAIALTHAFYARMGTAKPL
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
Q72JP3
B9M9X6
CAS2_ACIET
CRISPR-associated endoribonuclease Cas2
Diaphorobacter
MRMLVFFDLPVVSKADRRAYTVFRRFLLNDGYDMIQFSVYGRILNGTDAAQKHMQRLLANLPSEGSVRVLTVTEKQFASMKLLVGLPLFQEKKVNAAQIALF
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
B9M9X6
A5GR53
MTND_SYNR3
Acireductone dioxygenase (Ni(2+)-requiring)
unclassified Synechococcus
MSQLTIYNAVSEGNDPPLPSLHTTDAAIVAAELSQRGIRFQQWPTHDELDAASSQEEILAAYSAEIAEVQAAGGYQTVDAISLGPDHPQRAELRQKFLSEHTHSEDEVRFFVDGRGLFCLHIGDEVLQVLCERNDWLSVPAGTRHWFDMGERPCFSAIRFFNNQDGWVAQFTGDPIAKRYPLLGS
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
A5GR53
B6J6A2
NUOH_COXB1
NDH-1 subunit H
Coxiella
MTDQLITLIWIIIKIVLILVPLLVAVAFITLAERKVIGYMQSRVGPNRVGFRGLAQPIADIFKLLLKEVIIPTASSRYLYLIAPILSLVPALAAWAVIPFAQGWVLANVNAGLLFLFAMTSLGVYGILVAGWASNSKYAFFGALRSAAQVVSYEIPMGFALVGVLLAAGTMNLQGIVLRQSGGLWHWFWLPLLPLFVTYWITAVAETNRAPFDVAEGESEIVAGFHVEYAGVTFALFFLAEYANMVLVSAIATVIFLGGWLSPFQGIPGLESLFAWVPGIVWFVLKLSLFIFTYFWMRATFPRYRYDQIMRLCWKVLIPVTLVWIIILALAIEFHWTHWL
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
B6J6A2
C0Z4Q5
SPED_BREBN
S-adenosylmethionine decarboxylase alpha chain
Brevibacillus
MEQKTEHNVTLHGFNNLTKSLSFNMYDICYTKTKEEREAYIEYIDEQYNAERLTSILKNVSDIIGAHVLNVAKQDYVPQGASVTFLVSEGPVVEVPTESYEESPGPLPENVVLQLDKSHITVHTYPEYHPTEGISTFRADIDVSTCGEISPLKALNYLIRSFDTDLMTIDYKVRGFTRDIHGYKLFIDHDISSIQNYIPEEIKELFHMIDVNVYQDNIFHTKCKRREFDLNNYLFGYTKDRLTPEEQEDITKQLQIEMDEIYYGKNFVN
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
C0Z4Q5
A6UVI4
RIFK_META3
Flavokinase
Methanococcus
MLNKLFGRVVSGKGEGKHYMSLPPYKEKFKNILGFEPYEGTLNVKLGYIINLNELNPIEVDDFYYKNNKYYGVKLIPVRICIKDYCVNGAIVYPKKTEHPNNVIELIAPIKLRKYLSLKNNYMVKIRL
Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).
A6UVI4
B3EFX7
GCST_CHLL2
Glycine cleavage system T protein
Chlorobium
MKKTALYSWHEQAGAKIIDFGGYLMPVQYSGIIAEHKAVREAAGLFDVSHMGNFYVRGVRAGEFLQYLTTNDLSKVSDGEAQYNLMLYTDGGVVDDLIIYRIDAETYFLIVNASNAQKDYAWIQKHIGAFEGVSLEDRTDELSLVALQGPMSGAILRKVFPDEDCNTLASFRFRKVYYNGTELLIARTGYTGEQGVEICLPNEAALELWSVLMKAGEEYGIQPIGLGARDTLRLEMGYSLYGHEIDSTVNPLEARLKWVVKMEKGPFIGKEACRQVELNPRYAVAGFSLDGRALPRQHFRLYNSDRQEIGTVCSGTLSPTLQEPIGTCSILREYSRPGTHVMVEIRGTMHQGVIRALPFVQR
The glycine cleavage system catalyzes the degradation of glycine.
B3EFX7
Q038S1
SYD_LACP3
Aspartyl-tRNA synthetase
Lacticaseibacillus
MSKRTCYAGDVTAEYVDQEVTLKGWVQKRRSLGSLIFIDLRDREGIVQLVFSEEFDKDALAVANSVRSEYVIEVQGVVKKRKPQAVNKDMKTGDVEVEVHTITILNKAKTPPFYIEDGVAVTEETKLKYRYLDLRRPEMQKNIFTRAHIMRSVHHFLDDNGFIDVETPTLTASTPEGARDYLVPSRVYPGSFYALPQSPQLFKQLLMGAGFDRYYQIARCFRDEDLRGDRQPEFTQIDLETSFLTAEEIQDITEGLIAKVMHDVKGIDVKLPFDRITWQDAMDKYGSDKPDLRFDMQIQDVSELVKDSDFKVFAGAVQNGGQVRAIVLPGGADKYSRKMIDAQQDYIKRFGAKGLAWLKVTSDGISGPIAKFFGDGADLVKAVGANAGDLVLFVADKAKVVADALGYLRTHFGHDLGLIDEQAFRFCWVVDWPLFEYDEGIQRWVPAHHPFTMPNEEDVHLLDTDPHAAHAQSYDIVLNGYELGGGSIRIHNREIQEKMLKALGFTPERAQKSFGFLLNALDYGFPPHGGLAIGLDRFVMLLTGRDNIRDVIAFPKNSKASEPMTSAPYPVADAQLKDLGIEVRADVDPEKEHEGDENLTE
Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).
Q038S1
Q7NCS3
ATPA_GLOVI
F-ATPase subunit alpha
Gloeobacter
MFTIRPDEISSVIRDQIQKYNTELQVTNVGTVLQVGDGIARVYGLEKCMASELLEFEDGTIGIALNLEEDNVGAVLMGAGRTIEEGSTVRATGRIASIPVGPAFLGRVVNALAIPIDGKGDIVGSETRLLESPAPGIIKRKSVYEPLATGITAIDAMIPIGRGQRELIIGDRQTGKTTIAIDTILNQKGKGVVCVYVAIGQKASTVAQIVEVLRSRGALEYTIIVAANANEPAALQYLAPYTGCTLGEYVMYNGLTLPGSDKKINAALLVYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSPDLGEGSLTALPIIETQAGDVSAYIPTNVISITDGQIFLDSGLFNSGLRPAIDAGISVSRVGGAAQTKAMKKVAGKLRLDLAQFSELEAFSQFASDLDKATQAQLARGLRLREILKQPQYSPLSVAQQVAIIYAATNGYLDDIDVKGIQPFKQQFLNYLDSSVSEYGQEIETTKALTDKAVDLLKKALNDFKTTVKK
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Q7NCS3
A7GX33
MURC_CAMC5
UDP-N-acetylmuramoyl-L-alanine synthetase
Campylobacter
MKKVHFIGIGGIGISAIARFLFEKGHKISGSDIKESKTTQELKEQGMDVITPHCKEAIKDQDFVVYSAAIKDDNVELVEARKKGIKCFSRKEILPYVLEDKRVFAVAGAHGKSTTSAMLSSLIEGSVIIGAISKQFGSNMRYAQSDNVVFEADESDSSFLNSNPYLAVVTNAEPEHMEHYDYDLAKFYAAYKGFLERAKVRVINAEDEFLSTLKLDAIRLFPSSDITELAMVVRDYQPYTSFNLKNLGKFEVFGMGQHIAIDASLAILAALHETPLKDIRENLLNFKGIKKRFDILSADKNFILIDDYAHHPTEIRATLNSVFEYAKLLGVSNVTAIFQPHRYTRLSTNLEGFKECFKGVDELVILPVYAAGEKPIEVDMKGAFSEYSPIFTDKVERVGEAIEFTDEFGVKNRLSDGIVVGFGAGDISVQLRGGY
Cell wall formation.
A7GX33
P15090
FABP4_HUMAN
Fatty acid-binding protein 4
Homo
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
P15090
Q12NL5
LOLD_SHEDO
Lipoprotein-releasing system ATP-binding protein LolD
Shewanella
MKPASTRLLAINAVSKVFHDGACETQVLHEVNLTVHRGEQLAIVGSSGSGKSTLLHIMGTLESPTSGTVLLEGENLHQLSSKRQAQIRNQDLGFIYQFHHLLPEFSALENVAMPAFIQGKNKAQTLAEAKALLERVGLGHRLTHLPSQLSGGERQRVAIARALINKPKLVLADEPTGNLDAVSGEAVYGLIRELAEQLGTAFVVVTHDANLAARMDRQVNMKDGILSQSETHR
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
Q12NL5
A4K2S2
KCNS1_LEMCA
Delayed-rectifier K(+) channel alpha subunit 1
Lemur
MLMLLVRGTHFENNWSKLIPPAPLDATVSEPPVPDSGEPDSGVPWRRSDEALRVNVGGVRRRLSARALARFPGTRLGRLQAAKSEEQARRLCDDYDAAAREFYFDRHPGFFLSLLHFYRTGRLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRVARPRAWDEDSDTPSSVDPNPDEISDVQRELARYGAARCGRLRRRLWLTMENPGYSLPSKLFSCVSIGVVLASIAAMCIHSLPEYQAREAAAAVATVAAGRSAEDVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLASVALGGNNHGGTSGEELGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEEDVGFDTIPACWWWGTVSMTTVGYGDVVPVTLAGKLAASGCILGGILVVALPITIIFNKFSHFYQRQKALEAAVRNSGHREFEDLLSSVDGVSDASLETSRETSQEGRSADLEAPSESPKPQIY
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
A4K2S2
B2VFY8
ENO_ERWT9
2-phosphoglycerate dehydratase
Erwinia
MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGLAAAPSGASTGSREALELRDGDKSRFLGKGVTKAVGAVNGPIAEAVTGKDAKDQANIDKIMIDLDGTENKSKFGANAILAVSLAAAKAAAAAKGMPLYEHIAELNGTPGKFSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRIGSEVFHNLAKVLKSKGMSTAVGDEGGYAPNLGSNAEALAVIAEAVKAAGYELGKDITLAMDCAASEFYKDGKYVLAGEGNKAFTSEEFTHFLEDLTKQYPIVSIEDGLDESDWDGFAYQTKVLGDKIQLVGDDLFVTNTKILKEGIDKGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGNRAPFNGLKEVKGQ
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
B2VFY8
Q72IG5
TRUD_THET2
tRNA-uridine isomerase D
Thermus
MDLVFRPERYPFLTQDLPGVGGEIRVEPEDFQVEEVPAYLPKGEGEHLYFLLEKEGRTTREVLEFLRDEVGVPEKEIGVAGLKDKRAKTRQWFSIPRKYEDALCLLENLQGVRLLAADLHTNKLRTGHLKGNRFHILIRRPKGGVAEAEAVLKRLAEKGVPNYYGPQRFGLGGLNPVRGYKLVKEGKGRGSPWLKRFLIGSLQSLLFNDWVALRMALGLYDRVVLGDWAKKHATGGEFLVEDPGEAERALRLEISATGPLFGKKYPEAQGEARAIEDEVLARYGLKREEFRARRGARRPIRVPLAEWKVEEAPEGLWLSFFLPKGSYATSLLREVMKVEALDHLEAEPAPEDAEGL
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Q72IG5
Q3IFH4
MDH_PSET1
Malate dehydrogenase
Pseudoalteromonas
MKVAVLGAAGGIGQALSLLLKTGLPAGSELSLYDVAPVVPGVAVDLSHIPTAVKVAGFGADALNEALKDADIVLIPAGMPRKPGMDRADLFNVNAGIIKTLAEGIVASCPKALVGIITNPVNGTVPIVAEVFKKAGTYDAKRVFGITTLDVIRSEAFVAELKGVDVATVKVPVIGGHSGTTILPLLSQVEGVSFTDEEVAALTPRIQNAGTEVVNAKAGGGSATLSMGAAAARFCMSLVKGLQGEDVVDYAYVAVENGDAEYFAHPVRLGKNGVEEILSYGELSAFETKAKNDMLETLKKDIKEGVDFMA
Catalyzes the reversible oxidation of malate to oxaloacetate.
Q3IFH4
P41653
YCF2_PINTH
Protein Ycf2
Pinus subgen. Pinus
MKKRRRPWIIKLEEIQSYQFLCNPWTKSNLIRLLIQILSRRERLIKLFDPRILSTLLLRDLRKSNPYFLVKGIVVLTLSILIYRFNHQSSMIDRKNFYSIKLFPIHNFMELGNETPEEYLKPFTQNWLRFPHLLLSFQLKRYYNRDFDPISLNSGYGKNTNKKDEIISKNQGPSETHSENDEKDINLKIDSTLNSTENEYWKPEKYLCEDPFTRNKTEIEQRRKRSILWDLSFIEREQTKIESDLSSKCLSKDYPISWAKELFTEDQRYTEENSFPLERKRFIENFTKSIRYSFFYILPIDEPCMGGPSATKKPIEDFNLSKRLFKIKKNVFSQDLRDSKSYSLMNRIVDLWKIKTYFEIENPSLNCAMRSFTLPWNLFSAFCDQSKGKYILHKNCLEMTDQFTLSITKPSQVHDKISFFIYYNKNGSLRSDRIFNHREKWKNQSLWVLLNIIDKADDYLDQIIDKQLSQIDSKNCLEIGTPFNNYRTEALGWYESIKYNIDNRYSKNLLNRFYFINRLSRNLKDQIRTNFIENENLNNVTKDTIDRHSSSWKKIKREWFNHSIIRIDKHINRNLNVYKWSNQTEYFMKYLKQVFSKKNYFKIVFDPIELCTNTNRDSIGWSVFLSLSESTVKILNSKFDIISNLNSKFDILISFFDFAFHGLQSMNYRLLNQLLDPIGTLIVRLKKFKTFLLYDHNLSQRSKLLIDEGTIAPFVTNKIPINPLIIDFFDNENNRMESFDNTYFSTISNDRDNWLNPVKLSDQSSLIASFHGANTLQFFDYLHHTRPNYRNRLPSDMKRFYIKRNNFTYGQLFNLLIIHNNLSSLPIGEIGPVHSEKETISFIKSQVSNILLPKYLKRKRSGDQTFVLIYDLYRSFNLLTRLNPFVREKRYLSSIEEISTTPLTKEQIVNFEKNFCQPFFKRSDSEENNFDQCFKRGFSSNVGLIQTRSYQDDLLSEMFSNKNEEIFPRIQDWFVTECLKNKIVNEDIDGRSTLSNSSKEEQNIYRISQIDSIFSKWDLFKTYMPWFFTSAWCKYIENMLLDTLSEILLHGSNPFVSILQNIKHNILLKRNILWELSHPLWEPIQCKLRTNLINKFFFPSNNFKDFFPYCKDFLIEETSDREKSSVPFIWAHMRLLNARGYKYGILIPFFVLGYSILQYFKVISFTFINIKRYFELIKYLKHPSYVIELQKMINPPVPNSFLYYTIDRDRSSSLPQIINSFFSMNMKRKRKTKRKTKNRNIKLLITIIRELNGLCSSMDISEKEMNLLVQFLMTEKALFKFESIFTYSPNLFKNEFGDQIIRQPGLIHLRYLAYTYQKGLINYGFNPFCLAERWVFLAFCQKITSSQILCQTNPTFHGKPFSLHSGSLLSKGILLIGPMGTGRSYLVKSLAADSYVPLIRISLKKLWYGEYLDYPLERIPTEFDPFVKDKMEDFHITLELAKRMSPCIIWIPNIHELNLNDATNYLFGFGFTDLFLSVLMNNLFRFRDGEKDSMRNILVIASTHIPQRVDPALIAPNRLDRSINIRMLVIPQRQREFPILLCSKGLYSVKFPDEFGSITIDYAVRDLAALADEALILSITRNKSVIDTNTIRSAIYRQIFHLQSMDNQVGSSQNDERIIYKVGKAFIQNTLRRNSPMNPLSTKKELWKKRFCYLSEWYLEPSIAETTMKELTILPHILGCLAGSAARDSWSISERNRENWIPFDKLAEHDLDIASSLLESILVEFPFSRLGICRGKSDKDQITFAPQLKMRDNLDLIRFMKEYELKFTPGAKQRDMDEELIKNVVWTPRIWRLSFLRSNRFDHIKTPNSLGSSYQFGSLRKRQMDRSLFPIQYPKQYKYSKKPLFFIGRRFLWDSFLFQEQRPVFSRREFFANEELLKRLYITYGARRLIAQPDFFPKKSIQSFFRRYDSKSTINSVLVMNWWKPLSLRHRHIEHFKRIQAIGIQLERMQPYFPIYSYNRWLTENSRERVDRFQSLIHRQRWLGTNRLLSNESFLYNTLFESYQYLSNLFLSNRMLLDQITKTLLENKWLFPNEIEHSIHTTGLRFDISWENME
Probable ATPase of unknown function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.
P41653
O58686
MRE11_PYRHO
DNA double-strand break repair protein Mre11
Pyrococcus
MKFAHLADVHLGYEQFNKPQRAEEFANTFKKALEMCVKESVDFIIIAGDLFNSSRPSPGTIKTAIKLLQIPKENNIPVFAIEGNHDRTQRGPSVLHLLEDLGLLYVIGLRQERVENEYLTSERVGNYWLVKGVYDNLEIHGMKYMSSAWFEANLNFFKGIFRPDEDAILVLHQGIRDITEKVFPSYSAELKLSDLPRGYLYYALGHVHKRFETNYGDSPVVYPGSLERWDFGDYAKRLVWNGVTFREEVGSDKGFYIVEDFTPRFVNIKVRDFIDVVIKGDSEREIKKAVKASLPHIPRNSYVRFNIKWRKPFDVEWIKEIVNAEYLRIHTAIIKDEKSMNGESVDIKSFFTEQEWKVIDLASSDEFESYIEKIVDILSGYEKKEEREKKESKIRKFERPKNPGDLTAWLRGG
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity.
O58686
P44626
LNT_HAEIN
Apolipoprotein N-acyltransferase
Haemophilus
MKNLNRILLSIKFMNKYFTYLIAIISGLLGVFAFSPFDYWPLAYVSLLGLLYVAKNPKKSTALLSTFLWAMGFFCFGVSWLNVSIHQFGGASLGVSYFLVGLLAAYLALYPMLFTYLVHHFKVQSAVIFAVIWTLTEFLRGWIFTGFPWLQFGYTQIDSPFYGIAPIFGVTGLTFFTVWASAVIFNLVSSLFKTKNLKLVLANALLLIIVGGLSAYSSRIHFVKSVEDKAISVTLAQGNIEQNLKWDPNYFYSTLAIYQKLITENLGKTDLIILPESALPTLENAITPFFEGLERAAKETKTEIMVGTVFQDTKSGKLLNSIMTAGNPDFPYQPNTQNRYNKHHLVPFGEYVPLESILRPLNSVFNLPMSAFQSGEAVQPSLIAKKRAFSPAICYEIIFGEQVRQNLKQDTDYLLTLSNDAWFGDSIGPWQHLQMARMRALELGKPLIRATNTGISVFVDAQGKVLAQAPQFIETTLTYKIAPAEGKTPYSVLGNMPLYALSLLFLLLHSMMAFIRRKMNIL
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
P44626
A6UZL2
RS4_PSEA7
30S ribosomal protein S4
Pseudomonas
MARYIGPKCKLSRREGTDLFLKSGARALDSKCKAENVPGQHGQRRGRLSDYGLQLREKQKVRRIYGVLERQFRGYYQEASRRKGSTGENLLQLLECRLDNVVYRMGFGSTRAESRQLVSHKAITVNGQTVNIPSYQVKAGDVVAIREKSRNQLRIAQALELCGQRGRVEWVEVDLDKKTGTFKSVPARSDLSADINENLIVELYSK
With S5 and S12 plays an important role in translational accuracy.
A6UZL2
Q2I3H1
COX2_ELEMA
Cytochrome c oxidase polypeptide II
Elephas
MAYPLQLGFQDATSPVMEELLHFHDHTLMIIFLISSLVLYIIMLMLTTKLIHTNMMNVQEMEMIWTILPAIILILIALPSLHTLYMMDEINNPLLTIKTMGHQWFWSYEYTDYEDLAFDSYMITTDSLKFGELRLLEVDNRMVLPTDLPVRVLVSSEDVLHSWAVPSLGLKTDAIPGRLNQVTLTSMRPGLFYGQCSEICGANHSFMPIVLELVPLKYFESWSASLA
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Q2I3H1
Q6G9M8
KHSE_STAAS
Homoserine kinase
Staphylococcus
MSNVLELTIPASTANLGVGFDSIGMALDKFLHLSVKETSGTKWEYIFHDDASKQLPTDETNFIYHVAQQVASKYSVDLPNLCIEMRSDIPLARGLGSSASALVGAIYIANYFGDIQLSKHEVLQLATEIEGHPDNVAPTIYGGLIAGYYNDVSKETSVAHIDIPDVDVIVTIPTYELKTEASRRALPQKLTHSEAVKSSAISNTMICALAQHNYELAGKLMQQDGFHEPYRQHLIAEFDEVKTIAIQHNAYATVISGAGPTILIFSRKENSGELVRSLNSQVVSCHSELVDINISGVKERIVYQ
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
Q6G9M8
A9WT66
WHIA_RENSM
Probable cell division protein WhiA
Renibacterium
MALTAAVKEELSRLEVRKSSVRKAEVSAMLRFAGGLHIISGRIVIEAEVDLAATARRVRVAIAELYGHQSEIIVVSGGGLRRGNRYVVRVVREGEALARQTGLLDSRGRPVRGLPSVVVNGSTADAEAVWRGAFLAHGSLTEPGRSSSMEVTCPGPEAALALVGSARRLGIAAKAREVRGVDRVVIRDGDTIAALLTRMGAHETLLVWEERRMRKEVRATANRLANFDDANLRRSAQAAVAAGARVDRALEILGDDVPEHLKYAGELRVAHKQASLDELGRLADPPMTKDAIAGRIRRLLAMADKRASDLGIPSTEANVTLEMLEE
Involved in cell division and chromosome segregation.
A9WT66
Q7YD16
CYB_LONCH
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Lonchophylla
MTNIRKTHPLLKILNSSFVDLPTPSSLSSWWNFGSLLGVCLAVQILTGLFLAMHYTADTATAFDSVTHICRDVNYGWVLRYMHANGASMFFICLYLHVGRGLYYGSYTYTETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTELVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLIMLTALSTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILVLAIVPVLHTSKQRSMMFRPLSQCLFWLLVATLLTLTWIGGQPVEYPYVIIGQTASVLYFMILLVLMPLTSIVENKLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q7YD16
A2RNN4
RL15_LACLM
50S ribosomal protein L15
Lactococcus cremoris subsp. cremoris
MELHSLKAAEGSRKVRNRVGRGTSSGNGKTSGRGQKGQKSRSGGGVRPGFEGGQTELFRRMPKRGFLNVNRKEYAIVNLETLNRLEDGATVSAETLVAAKIVKDVKSGVKVLANGELTAKNLTVKVAKVSAAAKAAIEAAGGSVEEA
Binds to the 23S rRNA.
A2RNN4
C6CNE4
PAGP_DICC1
Lipid A acylation protein
Dickeya
MRLTLTSRSRLFVLSSLLFISTFDVLSAQAAPANTAPSFWQRAGDNLSDTWHHWQSQDLYVPVMTWHNRWTYDKEKTDRYNERPWGAGYGVSRLDCDGDWHSLYMMAFKDSFNKWEPIGGYGYEKRWRPLEDQDFQLGLGFTAGVTLRDNWNYIPLPVLLPMASLSYQRLSFQATYIPGTYNNGNVFFAWLRWQF
Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.
C6CNE4
C4LJL7
ATPD_CORK4
F-type ATPase subunit delta
Corynebacterium
MHAASRESMTELATTLDNTVAQSNAAVDGAQIGPELFDVVEVLDSNRDLRVALIDPAASSEKRADLADRVFGEKLNQASRSVLRSAVDKDWSNTRDFRNGLVQLGRRALFRAAEADDKLTTVESELFQLARVLEDAPQLEMLLADRQASADRRRQLLASVLYGKVTSITETLALQAISRAKQRPVEACETLSREAAQLRGYEVAHVVTAGELSDTQRSTLADKLGRIYGHKMSIHGEVDPSILGGMVIRVGDERIDGSTSGKLEKLRRAFA
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
C4LJL7
Q65HI8
FOLD_BACLD
Methenyltetrahydrofolate cyclohydrolase
Bacillus
MTATIIDGKETAKEKRGQLAKEVEELKKQGVTPGLAVILIGDDPASLSYVRGKKKAAEAMGIRFQLDHFDASFTEQELLEVIDQYNQNDDFHGILVQLPLPDHISEQAVIERISPEKDVDGFHPLNVGKMLLGEDTFLPCTPAGIVELLKKTEIDLSGKEVVVVGRSNIVGKPVGQLLLNENATVTYCHSRTADITAHTKKADILIVAVGKANFIKADQIKEGAVVIDVGVNRLDNGKLAGDVDFEEAKEKASYITPVPGGVGPMTITMLAHNTVKSAKRTIQL
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q65HI8
Q4JSW2
MSHA_CORJK
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase
Corynebacterium
MRVAMISMHTSPLEQPGTGDAGGMNVYVKNIAEQLERRGVIVDVFTRATRPLQGEVVNVRPGLRVINCVAGPYEGLSKEELPTQLAAFTGSILAFCREEGVSYDLIHSHYWLSGQVGWLLRDLWQVPWVHTAHTLAAVKNNSLADGDSREPESRRICEQQIVDNADLLIVNTDQEVQDLIEGYDATTCAIRVVPPGADVDRFTPGSDRATERSRRELGIPFRTKVIGFVGRLQRLKGPQVLLRAVAELLDRHPQQQLAVVICGGSSGAGGNELERLQLLAEELGISRCVRFLAPRPPEELVGVYRAADIVAVPSYNESFGLVALEAQACGTPVVATRTGGLPIAVDGGKSGLLVDGHDPSDWADALGKLVLDDDLRIAMGEYAPSHAAKFSWQASAEALHKLYEELPPAGHRGERQPAG
Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2-acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway.
Q4JSW2
Q6FDF6
BETT1_ACIAD
Osmo-independent choline transporter BetT1
Acinetobacter
MWSKRDEQKTYPPIRLNPFVFWSSAISISIFGMLFVLFPETSQHGLTWIQQQVNQLFGWYYMLVIILSLGFVAWLAFSQVGNIPLGKAQDKPEFGYLVWTSMLFSAGIGIALLYYGVAEPVDHFLRPPEGQGGTVEAAQNAMMYSFLHWGIHGWVLYALVGVTLGYFAFRRDLPLALRSALYPIFGERIHGLVGHMVDGFGILATIISLVTNLGIGALVMISGISYLFPDLPNTSSTLVVTVIMMMLVATLTTVIGIEKGLAWLSRINLRLLYLLLLFVFLTGPTNHLLNGLVQNTGDYLSHFVQKSFDLYLYDKNATGWLASWTIFYWAWWIAWAPFVGMFIARISKGRTIREVVLGVCLIPLGFTLAWISIFGNTAIDLILNHGQQIIGSLVIQDPALSLFKLLEYLPFHPYVAGIVVVICFVLFLTPVGSGTLMIANLSSQGGSSDSDSPIWLRVFWSIAITIVSIGLLLAGSFSAMQSAVVLCGLPFSVILLLYMFGLAKALKQETQQPVVESHTTETSGSD
Sodium-independent high-affinity choline uptake system. Uptake is not proton coupled. May play a role in metabolic adaptation to choline-containing environments.
Q6FDF6
B6IPH8
DAPE_RHOCS
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Rhodospirillum
MAPDPIALARDLIRCPSVTPADAGALDRVQSVLEGLGFTCHRLPFQEPGTERVDNLYARLGDKGPNFCFAGHTDVVPAGDAAAWTVDPFGGEIIDGRLYGRGAADMKGGVAAFIAAVGSFLERNGPPAGSISLLITGDEEGPAVNGTRKVLDWMAAAGERIDACLVGEPTNPRALGDMIKVGRRGSLTATLTALGAQGHTAYPHLADNPLPRLAEALHLLASSPLDMGTPHFQPSTLALTSIDVGNPASNVIPARGTARFNIRFNDLHTPESLEAHIRDVLEEVGGAWELALQTSGVAFLTPPGALSDIVAAAVEAHTGRTPELSTSGGTSDARFIKDHCPVVEFGLVGASMHKVDENVAVADLLELTAIYRTVLERWFAGAEPRT
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
B6IPH8
Q5HB44
RSMH_EHRRW
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Ehrlichia
MYHTPVLLKEMLDILSPQNGGIYVDATFGSGGYSRAILNSADCQVYAIDQDEYTYTFYEKLSNDFPNRIHFFINKFSKIQQILNNVQIKKVDGVVFDIGVSSMQLEDASRGFSFSKNGPLDMRMSTSLSGVDARMFVNTVSEVEMANVIYQYGGEKYSRKIARAIVNARNKNMINTTGELASIIRSVVSRSKNHSIDPATRTFQAIRIWVNKELEELEKGIACAANILNQGGKIIVISFHSLEDRIVKVIFKLLCDGKSVNLLNLGLGFQLINKKIIRPTAEEIHSNPRARSAKLRAILKL
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
Q5HB44
Q6GPK9
TAOK2_XENLA
Thousand and one amino acid protein 2
Xenopus
MPSNARAGNLKDPEVAELFFKDDPEKLFADLREIGHGSFGAVYFARDIRNNEVVAIKKMSYSGKQSNEKWQDIIKEVKFLQKLRHPNTIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEMEIAAITHGALQGLAYLHNHNMIHRDVKAGNILLTEPGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITSIELAERKPPLFNMNAMSALYHIAQNESPVLQSNHWSEYFRNFVDSCLQKIPQDRPTSDMLLKHRFLQRERPQTVIMELIQRTKDAVRELDNLQYRKMKKILFQDTQNGPNTETTEEEEEAEQFLHCTGTITSMESSQSVPSMSISASSQSSSVNSLADASDDSGEMAMMQEGEHTVTSNSSVIHRLPAHDNIYDDPYQPEMEAQQSSSAARRRAYCRNRDHFATIRTASLVTRQIQEHEQDSALREQMSGYKRMRRQHQKQLMALENKLKSELDEHQQRLDKELEAHRSNFSAENEKISKKHQAIFEKEAKGGMTEEKKFQQHILGQQKKELTNLLESQKRQYKIRKEQLKEELQENQSTPKREKQEWLLRQKESMQHYQAEEEANLLRRQRQYFELQCRQYKRKMLLARHNLDQDLLREELNKKQTQRDLECAMLLRQHECTQELEFRHLQLLQHTRSELIRMQHQTELGNQLEYNKRREQELRQKHAAEVRQQPKSLKSKELQIKRQFQDTCKIQTRQYKALRNHLLETTPKSEHKSILKRLKDEQTRKLAILAEQYDHSINEMLSTQALRLDETQEAEYQELRIQLQKELELLNAYQSKIKIHTDAQHERELKELEQRVSIRRALLEQRIEEEMLALQTERSERIRSLLERQAREIEAFDSESMRLGFSNMALTGIPAEAFNQGYQAPPPGWPSRPVPRSGSHWSHGVQNTGAPQLWRQPTLLAPPSASWGLHPPGSSSSLSALPSSSSSSSSSPSSSSGGRPGLLLLRNSPQPLRRGGSGGPSEAGLSRSTSVTSQLSNGSHLSYS
Activates the JNK MAP kinase pathway.
Q6GPK9
Q47F82
LPXD_DECAR
UDP-3-O-acylglucosamine N-acyltransferase
Dechloromonas
MASLGKVVLTLADIAAQLGGDVLGDSQTPISRVAPLATAGEGDITFLANPKFRSQLSACKASAVILRPDVAEEFPGPRIVTGNPYAYYARVATLLNPYQSGLSGVHASAVVESPVPDSVAIAPNVYIGKDVTLGENVVINAGCVIGDGVSIGAGTVLYANVTVYYGCSIGQQCIIHSGAVIGSDGFGFAPEGQSWIKIPQIGRVVIGNDVEIGANTTIDRGALEDTVIGDGCKLDNLVHIGHNCKIGNNSVLAGCTGVAGSTVFGEHCVVGGAGMISGHLNIAAGTTISGGTTVMKSILNPGVYTSVFPLDTHEEWLRNASHIRRLSKLAERVSELEKKLKEKDIEG
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Q47F82
D7SMN6
FULL_VITVI
VviFUL2
Vitis
MGRGRVQLKRIENKISRQVTFSKRRSGLLKKAHEISVLCDAEVALIVFSTKGKLFEYSSDSSMERILERYERYSLSERQLLSTDPDPQGNWSMDYPKLTARIEVLQRNLRHFVGEDLDPLSLRELQNLEQQLDTALKRIRTRKNQLMHESISELQKKEKSLVEQNNALAKKVKEKEKVEQNNRAQWEQQNNIGQNSSAYVVPPPPLQLPSLTIGGSFVGRAVEEDGAEARPSPNTLMPPWMLRHVNE
Probable transcription factor involved in flower development.
D7SMN6
P98023
COX2_TRYCR
Cytochrome c oxidase polypeptide II
Schizotrypanum
MSFILSFWMIFLIDSVIVLLSFVCFVCVWICVLLLSTVLFVTKINNIYCTWDFVSSKFVDTYWFVIGVMFIMCLLLRLCLLLYFGCLNFVSFDLCKVVGFQWYWVYFLFGETTIFSNLILESDYLVGDMRLLQCNHVLTLLSLVIYKLWVSAVDVIHSFTLASLGIKVDCIPGRCNEIILFASNNATIYGQCSELCGVLHGFMPIVICFI
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
P98023
Q0BYB7
RL2_HYPNA
50S ribosomal protein L2
Hyphomonas
MALKTFNPTSPGRRQLVLVDRSALHKGKPVKALTQGLSSKGGRNNQGRITVRHQGGGVKRLYRQVDFKRTRWDIPATVERLEYDPNRTAFIALIKYQDGELSYIIAPQRLEVGDTVITSATADIKPGNTLPLKSIPVGTIIHNIELKPQKGAQMVRSAGTYAQLVGRDSGYAQIKLASGELRMVLDSCLATIGAVSNPDKMNEVSSKAGRNRHLGKRPTVRGVVMNPVDHPHGGGEGKSSGGRHPVSPWGKKTRGPKTRNNKVTDRLIIRRRNAKR
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Q0BYB7
A0A348G5W0
TX14A_ODOMO
Poneratoxin
Odontomachus
MKPSSLTLAFLVVFMMAIMYNSVQAEALADADAEAFAEAGVKELFGKAWGLVKKHLPKACGLLGYVKQ
This homodimer composed of two cationic amphipathic alpha-helical peptides has antimicrobial activities against E.coli (MIC=3.1 uM), S.aureus (MIC=3.1 uM), and S.cerevisiae (MIC=3.1 uM).It also shows histamine-releasing activity (66.4% at 10 uM) and a weak hemolytic activity (10.5% at 50 uM).
A0A348G5W0
O93870
FCR1_CANAX
Fluconazole resistance protein 1
Candida
MSDDHSIHSHTQGLHHIKKKRVGKACDSCRIKKTKCDGKKPCNRCTLDNKICVFTEKKKTKEKKHPSGYVELLEARLDILTRSLEKLIELSRPHLQFIDDIITEEKSVDQEKSSPASSTPNSSSSDHHDDVEEQNSTGVVAPINKVVSYLIKEQGLLKNIPLEWEQGTEIAANFDPNRNLKSSSRLFAEHKGEAFIGSPVTSPQQMPTSNPFRRTSMFKEELESPSSDHYNESIFSQSVDEPYIKKEPNSAQFSKGTFSPQQQQLQQQQQMLNQFSLNTSRDISDIESDSSNKEDGLNSGSVSPPTSNYRSFSLFSDSNGEPILGKTSSLTSLTNKYENHSLSSPQTAINPVFNNSTTGPILTTLRRNSSSHSQKTLGSIQLQQKPRGSVHKPVRNHSRVSSFDKRMESTATAAATVAAVSGSVQLSQNTTPQNLPHLDNSQNNNYLRDNGMNNIGAGSVGGGLTFGAPSFTQPLSPSDDAIVYPTNQFTNRPATVSTFGGGLDVLVDNSLDPFFNI
Transcription factor that acts as a negative regulator of fluconazole resistance in C.albicans. Also confers fluconazole resistance in S.cerevisiae by activation of the PDR5 gene.
O93870
Q1G3V9
EPFL8_ARATH
MEPFL8
Arabidopsis
MDSSRKYKRCGFGAALFVANIFFSLLSLHCISGAHGHQQRMKESVMGSEPPVCATKCRNCKPCLPYLFDIRGAHDDDDDSEPYYPVKWICRCRDRVFEP
Controls stomatal patterning.
Q1G3V9
Q9XP84
CYB_SMIGI
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Sminthopsis
MINLRKTHPLMKIINHSFIDLPAPSNISAWWNFGSLLGICLVIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILLLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGTTLAEWIWGGFAVDKATLTRFFAFHFILPFIIMALVIVHLLFLHETGSNNPSGINPDSDKIPFHPYYTIKDALGLMFLLLVLLSLALFSPDSLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLIIPFLHTANQRSMMFRPVSQTLFWILTANLITLTWIGGQPVEQPFIIIGQLASILYFTLLLVLMPLAGMFENYMLEAQR
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q9XP84
Q9SVP6
PILR2_ARATH
Pinoresinol-lariciresinol reductase 2
Arabidopsis
MKETNFGEKTRVLVVGGTGSLGRRIVSACLAEGHETYVLQRPEIGVDIEKVQLLLSFKRLGAHLVEGSFSDHQSLVSAVKQVDVVVSAMSGVHFRTHNIPVQLKLVAAIKEAGNVKRFLPSEFGMDPSRMGHAMPPGSETFDQKMEIRNAIKAAGISHTYLVGACFAAYFGGNLSQMGTLFPPKNKVDIYGDGNVKVVFVDEDDMAKYTAKTLNDPRTLNKTVYVRPTDNILTQMELVQIWEKLTEKELEKTYVSGNDFLADIEDKEISHQAGLGHFYHIYYEGCLTDHEVGDDEEATKLYPDVKYKRMDEYLKIFV
Reductase involved in lignan biosynthesis . Unlike conventional pinoresinol reductases that can reduce both pinoresinol and lariciresinol, PRR2 shows a strict substrate selectivity for (-)-pinoresinol . No activity with (+)-pinoresinol or lariciresinol . Abstracts the 4R-hydride from the NADPH cofactor during catalysis .
Q9SVP6
Q6A7P6
PNP_CUTAK
Polynucleotide phosphorylase
Cutibacterium
MEGPGLEFTEAIIDNGKLGKHVVRFEAGLLAQQADGSAAVYLDGDTMLLSATTAAKTPRDSIDFFPLTVDVEERMYAAGRIPGSFFRREGRPSEGAILACRLIDRPLRPSFVKGLRNEVQVVVTVMALNPAVYYDVVAINAASMSTQLAGLPFSGPIGGVRMALIDDQWVCFPSVDQRKESTFDMVVAGRVLADGDVAIMMVEAESTPATWGLVRGGRTAPTEEVVATGLEAAKPFIKVLCDAQVALAAKLPKETYDFPVFKDYEDDVYAAVEEKAADELSRIEQIAAKLERQEAESELKARIKAELAETFPEREAEISGAFKAVMKKIVRKRVLDEGVRIDGRGPRDIRSLSAEVGIIPRVHGSALFQRGETQILGVSTLNMLDMEQKLDTLSPENTRRYMHNYNMPPYSTGETGRVGSPKRREIGHGNLAERALIPVLPTREEFPYAIREVSEAIGSNGSTSMGSVCASTLALLNAGVPLRASVAGIAMGLMSETDEDGKTKYLALTDILGAEDALGDMDFKVAGTSEFVTALQLDTKLDGIPADVLAGALKQAKEARTAILEVMNEAIDSPDEMAPTAPRIITVHIPVDKIGEVIGPKGKMINQIQDDTGANISIEDDGTIFIGADNGDSAESARSMINAIANPQMPEVGERYLGTVVKTTSFGAFVSLLPGKDGLLHISKMRDLNDGKRVEAVEDVLSVGQKIQVEIAEVDDRGKLSLVLASDEDDADE
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Q6A7P6
Q8QGQ7
BMAL2_CHICK
Brain and muscle ARNT-like 2
Gallus
MAEAGVGSAEGAEEERRAVEENFPVDGNSCIASGVPSLMNPITKPATTSFNNSVVEIPRKRKGSDSDNQDTVEVDGDPQKRNEDEEHLKIKDFREAHSQTEKRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLKSLKGSTSSYTEVRYKPSFLKDDELRQLILRAADGFLFVVGCNRGKILFVSESVCKILNYDQTSLIGQSLFDYLHPKDVAKVKEQLSSSDVSPREKLVDGKTGLQVHTDFQAGPARLNSGARRSFFCRIKCSRTTVKEEKECLPNPKKKDHRKYCTIHCTGYMKNWPPSEVGVEEENDVEKNSSNFNCLVAIGRLHPYIVPQKSGEIKVKATEFVTRFAMDGKFVYVDQRATAILGYLPQELLGTSCYEYCHQDDHNHLAEKHKEVLQNKEKVFTNSYKFRAKDGSFITLKSQWFSFMNPWTKELEYIVSNNTVVLGHNESAEEQVSYGSQPAEGAVKQSLVSVPGMSSGTVLGAGSIGTEIANEILELQRLHSSPPGELSPSHLLRKSPSPALTVNCSNVPNKELIQLCPSEAEVLETSEQNQGAIPFPSNEPLLGGNSQLDFAICENDDTAMTALMNYLEADGGLGDPAELSDIQWAL
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence. CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3'.
Q8QGQ7
A8M0Z1
RL21_SALAI
50S ribosomal protein L21
Salinispora
MYAIVKTGGKQYKVAEGDVIEVEKLAGAPGDAVQLAAVLLVDGDDLVTDAAKLAEVEVSGEIAAHTKGPKIRIHKFKNKTGYHKRQGHRQPLTQVKVTGISSGK
This protein binds to 23S rRNA in the presence of protein L20.
A8M0Z1
P04927
SANT_PLAFF
S-antigen protein
Plasmodium (Laverania)
MNRILSVTFYLFFIYLYIYETYGKVKNTDKELSDIYGTKYYLRSGFFNSKKCKGHKYEDLQAEGEGENDKEEDSNNEEMNIDEENGLIEGQGESEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGLEDPAKASQGGAEGHGKHAPNKENKNKNKESIKNIMNMFI
S antigens are soluble heat-stable proteins present in the sera of some infected individuals.
P04927
Q8EQV2
EFTS_OCEIH
Elongation factor Ts
Oceanobacillus
MAITAQMVKELREKTGAGMMDCKKALQETNGDIEQAIDFLREKGMAKAAKKADRVAAEGLTHIEVEGNKAAIIEVNCETDFVTKNDQFKQLLSELGKHIVANEPATVEEALQQKLHGDGETVESVITNAVAKIGEKISLRRFEVLEKTDNDAFGAYLHMGGTIGVLSLLEGTTDEQVGKDIAMHVAAVNPRYVTRDEVAEEEVNREREVLKTQALNEGKPENIVEKMVEGRLGKFFEDIVLLEQSFVKDPDQKVKKYVADKGAAVKTFVRYEVGEGMEKREENFAEEVMSQIKK
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
Q8EQV2
Q8DZL4
GUAC_STRA5
Guanosine 5'-monophosphate oxidoreductase
Streptococcus
MFNDIPVFDYEDIQLIPNKCIISSRSQADTSVKLGNYTFKLPVIPANMQTIIDEEVAETLACEGYFYIMHRFNEEERKPFIKRMHDKGLIASISVGVKDYEYDFVTSLKEDAPEFITIDIAHGHSNSVIEMIQHIKQELPETFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCSKAARKPIIADGGIRTHGDIAKSIRFGASMVMIGSLFAGHLESPGKLVEVEGQQFKEYYGSASEYQKGEHKNVEGKKILLPVKGRLEDTLTEMQQDLQSSISYAGGKELDSLRHVDYVIVKNSIWNGDSI
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Q8DZL4
P0DTZ6
O1634_CONCL
O1_cal6.34
Californiconus
MKLTCVLIVAVLILTACQVIAADSSCWFCSTGFNKCCESTGDCMTYPSEYNASCPEA
Probable neurotoxin.
P0DTZ6
Q5V468
MCT_HALMA
Succinyl-CoA:mesaconate CoA-transferase
Haloarcula
MGALDDLRVLDLTQVLAGPYCTMLLADMGADVVKVERPGGDLIRSNPPFVSDGDEEAYGGYFQSVNRGKRSLELNLGTDEDREAFLSLVERADVVVENFKAGTMEKFDCGYETLREHNPDLIYSSIRGFGDPRTGETHRQGQPSFDLIAQALGGVMEITGQSDGPPTKVGPGVGDLFTAVLNAVGILAAVHHRERTGEGQYVDTAMYDSMVSLCERTVYQYSCDGESPTRQGNSHPTLFPYDSFEAADGHVVIAAFADGHWEALCEAMERPDLAAEYPDAGSRIANRESLRAEIAEWTTAIDSETLLDLLEGRVPAAPVQNTADIFDDPHIHDREMLAEVDQPGADDQMTIAGSPIKMTETMPSPGGRAPLLDEHKTELLDEAGVDTGTNRVESDD
Involved in the methylaspartate cycle. Catalyzes the transfer of the CoA moiety from succinyl-CoA to mesaconate to generate mesaconyl-CoA (2-methylfumaryl-CoA) and succinate.
Q5V468
Q1Q8F6
ANMK_PSYCK
AnhMurNAc kinase
Psychrobacter
MDDLNYATLTDALEQTVFENFDDGLYIGMMSGTSLDGMDAVLCQFSEKDNTQQPMHVLATHSQDFPPRLREVLLALCQPNGIQALTPSDDEPNSELDWFGWASKEYAEFSSDVVNTLLQQSNTDSESVLAIGCHGQTVRHRPQMGFSLQLVDANIIAERTGISVVSDFRRRDMAVGGQGAPLVPAFHQALFAVPDSTRVLLNLGGIANIAVLPAISNDLVDSNEHSENQPSDSVVGYDTGPANLLLDAWTTLHTDKDYDAGGTWAQSGQVVEPLLNQLLEHPFFKKTYPKSTGREDFNLAWLQDELQKFDQASADVRYSSADVQATLTELTAISASAQINLFINASSSNAVYVCGGGALNNYLMTRLQVHLQRCKVETTASLGLEPTWVEAVAFAWLARQTLMGETGNLPAVTGASKGVVLGQVCFA
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
Q1Q8F6
P49587
PCY1_PLAFK
Phosphorylcholine transferase
Plasmodium (Laverania)
MDSSNYFHDCKTMLSEHNESIESSNNDINGKQKEHIKKGNSENQDVDPDTNPDAVPDDDDDDDDNSNDESEYESSQMDSEKNKGSIKNSKNVVIYADGVYDMLHLGHMKQLEQAKKLFENTTLIVGVTSDNETKLFKGQVVQTLEERTETLKHIRWVDEIISPCPWVVTPEFLEKYKIDYVAHDDIPYANNQKKKKKKKSKGKSFSFDEENEDIYAWLKRAGKFKATQRTEGVSTTDLIVRILKNYEDYIERSLQRGIHPNELNIGVTKAQSIKMKKNLIRWGEKVTDELTKVTLTDKPLGTDFDQGVENLQVKFKELFKIWKNASNKLITDFTRKLEATSYLTSIQNIIDYEIENDDYASSNFDDETSS
Controls phosphatidylcholine synthesis.
P49587
A5D6D2
PDXT_PELTS
Pyridoxal 5'-phosphate synthase glutaminase subunit
Pelotomaculum
MKVGVLALQGAFREHQKVLAACGAESVQVRKPEQLEDISALVIPGGESTTIGKLLLEFNLFEPLVKLGQGGLPVFGTCAGMILLAREIAGSGQPRLGLMDISVERNAFGRQVESFEADLDIPVLGEEPFRAVFIRAPYIIEAGGGVEVLARFGEKIVMARQGRCLAAAFHPELTGDLRIHRYFLEKCVRAGQNCKG
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
A5D6D2
A8EXK5
RL1_RICCK
50S ribosomal protein L1
belli group
MSNKKDIAVKNSGGKKIREAREKVKSDTLYNLTNAVERLKSASYVKFDPTLEIVMKLGIDPRHSDQMIRGVVNLPAGTGKTVRVAVICKAERVEEAKSAGADLVGSTSIIDEIKAGKINFDVCIATPDMMAAIGSVARILGPKGLMPNPKLGTVTLDIKNAIKNAKSGQVEYRAEKAGIIHAGLGKLSFSDQDLLQNLNEFIEAVIKAKPAGLKGSYLKAMYLSSTMGASVQIDLTSIA
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
A8EXK5
Q7NJT1
GLPK_GLOVI
Glycerokinase
Gloeobacter
MVFASAGAAVSGAILALDLGTTGIRALLFDPSGAVAAGAYREVPQIYPQPGWVEHDPQTIWQLTCEVVAEVQAQSAARIAAVGLTNQRETCLLWDAATGTPHGNAIVWQDRRTAALCQKLRAEGWEAPIRQRTGLVIDAYFSATKLAWLLAHRRPYYPGLKAGTIDSWIIWKLTGGRVHATDTSNASRTMLFNLHTRDWDPELLELLAIPAEILPAIKPSLGVLAETDVRVLGYSAPIAGILGDQQAALFAHGCDRPGLVKCTYGTGSFLVAHTGDRPIRSRHQLLTTVAWSDRTSTGYALEGALFTTGASVQWLRDGLGIIETADESEALAASVPDSGGVYFVPALSGLGAPHWDMGARGLLIGLTRGSGRGQIARAVLEAIAFQTREVTDALAADMGTPLTRLKVDGGAVRNNLLMQLQADVLGVPVERPQLIDTTAQGAAFAAGLGTGFWGDYAELVAARPIDRVFESGERQLVLQAHYAVWQRAVERSREWVR
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Q7NJT1
Q8D4N8
RIMO_VIBVU
Ribosome maturation factor RimO
Vibrio
MTVQTFTPNQTTTLDTAKKTIEQQSQELTPSGGNKIGFVSLGCPKNLVDSERILTQLRTEGYEIVNSYHDSDVVIVNTCGFIDSAVQESLDTIGEALKENGKVIVTGCLGAREDEIREVHPGVLGITGPHAYENVLEHVHQFAPKPEHNPFTSLVPDHGVKLTPKHYAYLKISEGCNHRCTFCIIPSMRGDLVSRPVGEILSEAERLKNAGVKELLVISQDTSAYGVDSKHSLGFANGSPVRQNIKALSEELGKMGIWVRLHYVYPYPHVDDLIPLMAEGKILPYLDIPFQHASPNVLKAMKRPGRAERTLDQIKKWREICPELVIRSTFIVGFPGETDEDFEMLLEWLKEAQLDRVGCFKYSPVEGAAANDIDDQISEEVKQERFECFMLVQQEISAAKLQKRIGSTMKVIIDEVDEEGAIGRTYADAPEIDGLVYLNGETSLKAGELVDVLIEHADEYDLWGSLVRA
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
Q8D4N8
A0LZ30
DAPA_GRAFK
4-hydroxy-tetrahydrodipicolinate synthase
Gramella
MEAFVGTGVALITPFKEDLSIDTEALSNLVKYQIENGIEYLVVLGTTAESATLTQDEKELIKKVVKEANAGELPLVLGVGGNNTAGVVEELQIADLDGFDAILSVSPYYNKPTQEGIYRHFEAISKASPLPIILYNVPGRTSSNVLPETINRIARNLKNVIGVKEAAGDIVQAMKMISLVPDDFKVISGDDMITLPMTLAGGKGVISVIGQGLPKEFSNMVRAGLEGKVSEAYQLHYKIAPSIEFIFAEGNPAGIKTLLAKKGIISNTLRLPLVEATETLQSKINSFVDNF
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
A0LZ30
Q756C3
CEF1_ASHGO
Pre-mRNA-splicing factor CEF1
Eremothecium
MPAVPIYVKGGVWSTVEDEILRAAVQRYGTHAWNKVASLLPRKSGKQCRARWEESVRPTRQGAWTAAEDATLAALARGGPQWRSVGAALGRPAAACAARWAELTGDQAVAGPAAGERIPGAEGLPAVPEEDEREMVAEARARLASTQGKKAARRARERQVEESRRVARLQKRRALLQAGVNSALPLPRAVRGQLDPNADVLYELAPAEGVFETANEAARDRAAREAYERQIEARGKRTARKQSRAPARAPATEQPALQVRRAIPRPPLELPVPEALLKNSAAPTAAVRRALARLWQGLPAAKNDFDVAPESEDEQPSGSADAAVQSTDMEVLLPWEPPLRQDLPPPPPPPPGLLAEHYRALAAAAAGGPACYDTPDVLRQREAIERALAAEPSPAMLHPQCELPRLPSLDALRAAAQPRPQRRLAAHAATDAGSRLLAYELLPDLATKQREYYVRYTAYELERTAVATRVRRLTAGR
Involved in mRNA splicing and cell cycle control.
Q756C3
C5BF98
MDH_EDWI9
Malate dehydrogenase
Edwardsiella
MKVAVLGAAGGIGQALALLLKTQLPSGSELSLYDIAPVTPGVAVDLSHIPTAVKVCGFGGEDASPALVGADIVLISAGVARKPGMDRSDLFNVNAGIIRNLIGQVARTSPNACIGIITNPVNTMVPIAAEVLKKAGVYNPNKLFGVTTLDIIRSNTFVGELKHLDPATLDIPVIGGHSGVTILPLLSQIPGVSLSEREVAELTKRIQNAGTEVVEAKAGGGSATLAMGQAAARFALSLVRAMQGDENVVECGYVESDGEYARFFAQPLLLGKAGLVQRLSIGTLSAFEQDALESMLEVLRKDIALGEDFINK
Catalyzes the reversible oxidation of malate to oxaloacetate.
C5BF98
P46377
FAS5_RHOFA
Uncharacterized oxidoreductase ORF5 in fasciation locus
Rhodococcus
MSGIWHTDDVHLTSAGADFGNCIHAKPPVVVVPRTVADVQEALRYTAARNLSLAVRGSGHSTYGQCQADGGVVLDMKRFNTVHDVRSGQATIDAGVRWSDVVAATLSRQQTPPVLTDYLGTTVGGTLSVGGFGGSSHGFGLQTDNVDSLAVVTGSGDFRECSAVSNSELFDAVRGGLGQFGVIVNATIRLTAAHESVRQYKLQYSNLGVFLGDQLRAMSNRLFDHVQGRIRVDADGHLRYRLDLAKYFTPPRRPDDDALLSSLQYDSCAEYNSDVDYGDFINRMADQELDLRHTGEWFYPHPWASLLIPADKIEQFIETTSSSLTDDLGNSGLIMVYPIPTTPITAPFIPIPHCDTFFMLAVLRTASPGAEARMIASNRLLYEQARDVGGVAYAVNAVPMSPGDWCTHFGSRWQAIARAKRRFDPYRILAPGYRMSFD
The FAS-operon encodes genes involved in cytokinin production and in host plant fasciation (leafy gall).
P46377
A5GAU3
RS13_GEOUR
30S ribosomal protein S13
Geotalea
MARIAGIDLPRNKRIEIALTYIYGIGRSTAQKILADAGVDSNTRSDNLTESEIARIRENIDKNVKVEGDLRRDISMNIKRLMDLGCYRGLRHRKGLPVHGQRTKTNARTRKGPARTVAGKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
A5GAU3
Q077R2
WFAP_ECOLX
UDP-Glc:alpha-D-GlcNAc-diphosphoundecaprenol beta-1,3-glucosyltransferase WfaP
Escherichia
MELVSIIIAAYNCKDTIYATVESALSQTYKNIEIIICDDSSTDDTWDIINKIKDSRIICIKNNYCKGAAGARNCALKIAKGRYIAFLDSDDYWVTTKISNQIHFMETEKVFFSYSNYYIEKDFVITGVFSSPPEINYGAMLKYCNIACSTVILDRTGVKNISFPYIDKEDYALWLNILSKGIKARNTNLVDTYYRVHAGSVSANKFKELIRQSNVLKSIGIKAHHRIICLFYYAINGLIKHCFSYRDKRNA
Catalyzes the addition of Glc, the second sugar moiety of the O56-antigen repeating unit, to GlcNAc-pyrophosphate-undecaprenol.
Q077R2
Q0AEI9
ATPA2_NITEC
F-ATPase subunit alpha 2
Nitrosomonas
MSVLDDVTEQQFEQNFNAWLDSLSTGATPTPVLTETGTVTEVADGVAIVSGLARALADELLVFASGVHGIVLDLEPGRLGIILLGPSEQIHLGETVYRTRKVVSVPVGSALLGRVIDAMGRPRDTLGPIDAIAEHPIEAEAPSILNRTQIFRPLATGLKAIDAAIPVGLGQRELIIGDRQTGKTSIAIDTMLNQARSDVLCIYCAVGQRGDAVARVIRALKDGEMLQRCIVMSAGDEEAPGLSYIAPYAAMTMAEYFSAQGQDVLVIFDDMTHHARSYRELSLLLRRPPGREAFPGDIFYVHARLLERAGQFGADIGGGSITTLPVVETQAGNLSAYIPTNLISITDGQIYLSPQLVRKNQFPAVDLGLSVSRVGSKAQNRTLRGVSGNLRVTLSQFEELEDFARFGTRLDDVTRARLARGSAVRTALRQAERDPMSALEQLAVLIAAMEGLFDQFNEQKINDAMRLVRDAAQQQLAVIEQRIIDNQTLQDDDHTLIVNCAQKALSIFDQPATNTK
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Q0AEI9
Q9FXA7
RGXT3_ARATH
Rhamnogalacturonan xylosyltransferase 3
Arabidopsis
MAQQSQRPISNRHISLLNRNGLILLLLLALFVILGVFLPLTKSSLFMFPNTTSSSLSPSSSLSVSDWRDYSLAQAVKFVAKNETVIVCAVSYPFLPFLNNWLISISRQKHQEKVLVIAEDYATLYKVNEKWPGHAVLIPPALDPQSAHKFGSQGFFNLTSRRPQHLLNILELGYNVMYNDVDMVWLQDPFDYLQGSYDAYFMDDMIAIKPLNHSHDLPPLSRSGVTYVCSCMIFLRSTDGGKLLMKTWVEEIQAQPWNNTQAKKPHDQPAFNRALHKTANQVKVYLLPQSAFPSGGLYFRNETWVNETRGKHVIVHNNYIIGYDKKMKRFQDFSLWLVDDHALESPLGKLEIYQEQNTTTEGKNLTKIVRKQRKNRGKKHKLP
Catalyzes the transfer of D-xylose from UDP-alpha-D-xylose onto L-fucose. Probably involved in the biosynthesis of rhamnogalacturonan II (RG-II) through xylosylation of the internal fucose moiety of the A-chain of RG-II, a structurally complex pectic polysaccharide of the primary cell wall. RG-II is essential for the cell wall integrity of rapidly growing tissues such as roots and pollen tube growth and elongation.
Q9FXA7
Q9JJC9
HERP2_MOUSE
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein
Mus
MDQSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKTHLSNVYPSKPLTKDQRLVYSGRLLPDHLQLKDILRKQDEYHMVHLVCASRSPPSSPKSSTDRGSHEALASSTSSNSDHSDSTTPSPSQESLSLVTGSSEGLRQRTLSQAQTDPAQSHQFPYVIQGNVDHQFPGQGVPPAFPVYPALSPLQMLWWQQMYAHQYYMQYQAAVSAQATSSAGSAQRAASSPLNLAHVPGEEPPPAPNLVAQENGPMNENVQMNAQGGPVLNEEDLNRDWLDWVYTFSRAAVLLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGQQQAPNNVDANNDGHNANNLELEEMERLMDDGLEDESGEDAGEDASAAQRPGLMASAWSFITTFFTSLIPEGPPQVAN
Could be involved in the unfolded protein response (UPR) pathway.
Q9JJC9
P0C5K8
SCX5_TITBA
T-alpha* NaTx3.4
Tityus
MNDFVFLVVACLLTAGTEGKKDGYPVEGDNCAFVCFGYDNAYCDKLCKDKKADSGYCYWVHILCYCYGLPDKEPTKTNGRCKPGKK
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission.
P0C5K8
Q7VR45
LPXK_BLOFL
Lipid A 4'-kinase
Candidatus Blochmannia
MLFNIWFGSSLCYLFLLPFSWVYGFFSTLNRISYKYGWRKVYRFSVPIIVIGNLTIGGNGKTPMVLWLIDQLKTRGWRVGVVSRGYGGRSDKYPIIINSTSCSKKCGDEPLLIWRRTGVLVSVSPNRVKAVSALLKKQPLLDIIISDDGLQHYALFRDIEWVVVHSLRRFGNGCWLPAGPMRERITRLNTVQAIIINGLSNDIQSGAILMQLCPRSIINLVTGEIRPIQPLKDVVAIAGIGYPKQFFMTLQDYGIFPIKTIEFSDHHMYSEIMLSSLTSGNEMLLMTEKDAIKCLDFAHENWWYVHIDVNIHQEDTKKLLSKIESTIQYYKNN
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
Q7VR45
A4VRE8
METK_PSEU5
Methionine adenosyltransferase
Pseudomonas
MSEYSIFTSESVSEGHPDKIADQISDAVLDAIIAEDKHARVACETLVKTGVAIVAGEVTTSAWVDLEQLVRDVIVDIGYNSSEVGFDGATCGIINIIGKQSVDIAQGVDRTKPEDQGAGDQGLMFGYASNETDVLMPAPIRFSHALVERQAEARKNGLLPWLRPDAKSQVTCRYENGQVVGIDAVVLSTQHNPDVKQSDLREAVMELIIKHSLPAELLHKDTQYHINPTGQFVIGGPVGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLADRCEIQVSYAIGVAQPTSISLNTFGTGKLGDDKIIALVREHFDLRPYAITRMLDLLHPMYRATAAYGHFGRTPYEMTVGADTFTAFTWEKTDKADALRAAAGL
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
A4VRE8
A0A1D8PC43
MVD1_CANAL
Mevalonate-5-diphosphate decarboxylase
Candida
MYSASVTAPVNIATLKYWGKRDKSLNLPTNSSISVTLSQDDLRTLTTASASESFEKDQLWLNGKLESLDTPRTQACLADLRKLRASIEQSPDTPKLSQMKLHIVSENNFPTAAGLASSAAGFAALVSAIAKLYELPQDMSELSKIARKGSGSACRSLFGGFVAWEMGTLPDGQDSKAVEIAPLEHWPSLRAVILVVSDDKKDTPSTTGMQSTVATSDLFAHRIAEVVPQRFEAMKKAILDKDFPKFAELTMKDSNSFHAVCLDSYPPIFYLNDTSKKIIKMVETINQQEVVAAYTFDAGPNAVIYYDEANQDKVLSLLYKHFGHVPGWKTHYTAETPVAGVSRIIQTSIGPGPQETSESLTK
Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway . MVD1 converts diphosphomevalonate into isopentenyl diphosphate . The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8. The diphosphomevalonate decarboxylase MVD then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).
A0A1D8PC43
Q6AD21
RPOA_LEIXX
Transcriptase subunit alpha
Leifsonia
MLIAQRPTLTEENISEFRSRFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFSTVPGVKEDVTEIILNIKGLVVSSEHDEPITAYLRKTGAGQVTAADISAPAGVEIHNPELVIATLNDKAKFEVELTIERGRGYVSAQQNRNEYSEAGQIPIDSIYSPVLKVTYRVEATRAGERTDFDRLVVDVETKPAISPRDAIASAGRTLVELFGLARELNSAAEGIEIGPAPVDQVLSSELSMPIEDLDLSVRSYNCLKREGINTVSELVSLSETQLMNIRNFGQKSVDEVKDKLTEMGLSLKDSVPGFDGAHFYSGYDEDESTTI
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q6AD21
Q1QDH1
RL6_PSYCK
50S ribosomal protein L6
Psychrobacter
MSRVAKAPVTLPNGVSVTLNDRQVEVKGKNGNMSLRLHELVELKQEDDAIIFSPTVDSKEAMMHTGTMRSLLNNLVIGVNEGFEKRLQLIGVGYRAQAAGNKVTLNVGYSHPVEYTLPEGVSAETPTQTEIVLKSNDKQQLGQAAADIRGFRPPEPYKGKGIRYSDEHVIRKEAKKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q1QDH1
A4QN56
MFS4B_DANRE
Major facilitator superfamily domain-containing protein 4B
Danio
MSPAEAAPRKKHVRFARMEGDVDHDDQEENTLFDKQKDVKEGLKSVLKGGKGILSQGSGQVDVVRPGRSKTGTCWRWLVSLALCASFLGLGMAISVLGPTFEDLAINVNKNISNLSYIFVGRASGYIGGSLLGGILFDFVNPHLLLGFALLTTAFGMSGTPFCKKAWVLTVLMSSVGVSMGVLDTGGNVLILNTWGEQAGPHMQALHFSFAAGAFASPIIAKLLFGHHNSSTNTSLMSGHASKTIDAVLPFSHPKGTSTIDLPWMWAYIVIGAFVLLVSLLFFSLYFCISTNSNRTKTASGKQQFSKHHNTLIILLSMFFFFYVGSEVAYGSFIFTYGKDYVHMEETEAAGLNSLFWGAFAAGRGLAIFFAACLHPGTLILLSLVGTTVSSLLLCLFSQNYPMLWACTALYGISMSTTFPSGISWVEQYTTVTGRSAAIFVVGAALGEMVLPALLGFLLGHVQNYPLLMYLTLCTATFTSILFPVLYKLASPEGNVTLRKSSGKCTIKDADDSEYRQALLENMEEQEENESEADLCNDADFEVIEMDDASLLSSPKSSPPADVAASVPDVHLVASPLSEPNMLSFSTDSPRSKL
May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.
A4QN56
C3RT18
GGN2_LIMKU
Gaegurin-LK2
Limnonectes
MFTMKKSLLLIFFLGTINLSLCEEERNAEEEKRDGDDEMDVEVQKRFLGPIIKMATGILPTAICKGLKKC
Has antimicrobial activity against Gram-positive bacteria S.aureus ATCC 2592 (MIC=2.5 uM), S.aureus ATCC 43300 (MIC=2.5 uM) and B.subtilis (MIC=20.0 uM), against Gram-negative bacteria E.coli ML-35P (MIC=50.0 uM), P.aeruginosa PA01 (MIC=10.0 uM) and P.aeruginosa ATCC 27853 (MIC=5.0 uM) and against fungus C.albicans ATCC 2002 (MIC=5.0 uM).
C3RT18
B2TY23
EFP_SHIB3
Elongation factor P
Shigella
MATYYSNDFRAGLKIMLDGEPYAVEASEFVKPGKGQAFARVKLRRLLTGTRVEKTFKSTDSAEGADVVDMNLTYLYNDGEFWHFMNNETFEQLSADAKAIGDNAKWLLDQAECIVTLWNGQPISVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVIKVDTRSGEYVSRVK
Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation.
B2TY23
Q88PC0
GATB_PSEPK
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Pseudomonas
MQWEVVIGLEIHTQLATQSKIFSGSATTFGSEPNTQASLVDLGMPGVLPVLNEQAVRMACMFGLAIDAEIGKRNVFARKNYFYPDLPKGYQISQMDLPIVGKGHLDIALEDGTIKRIGVTRAHLEEDAGKSLHEDFSGSTGIDLNRAGTPLLEIVSEPDMRSAKEAVAYVKAIHALVRYLGICDGNMAEGSLRCDCNVSIRPKGQTEFGTRCEIKNVNSFRFIERAINSEIQRQIDLIEDGGKVVQETRLYDPNKDETRSMRSKEEANDYRYFPDPDLLPVVIEDSFLETIRAGLPELPPQKVERFQTQYGLSAYDANVLASSREQADYFEEVVKIGGDAKLAANWVMVELGSLLNKLGVEIDQAPVSAAQLGGMLLRIRDNTISGKIAKTVFEAMAAGEGDADSIIESKGLKQVTDTGAIDKMLDEMLAANAEQVEQYRAADEAKRGKMFGFFVGQAMKASKGKANPGQVNQLLKAKLEG
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Q88PC0
Q0WT48
DNJ21_ARATH
Translocation protein SEC63 homolog ERDJ2A
Arabidopsis
MAASEENSALFPIFILTIMAIPLVPYTMVKLSGALSKKQRTIHCQCLECDRSGKYKRSLFKKISNFSTWSNLTLVLLWVVMIFLIYYTKNMSREAQVFDPFSILGLEPGVTDSEIKKAYRRLSIQYHPDKNPDPEANKYFVEFISKAYQALTDSVSRENFEKYGHPDGRQGFQMGIALPQFLLDIDGASGGILLLWIVGVCILLPLVIAVIYLSRSSKYTGNYVMHQTLSAYYYLMKPSLAPSKVMEVFTKAAEYMEIPVRRTDDEPLQKLFMSVRSELNLDLKNMKQEQAKFWKQHPAIVKTELLIQAQLTRESGVLSPALQGDFRRVLELAPRLLEELLKMAVIPRTAQGHGWLRPAVGVVELSQCIVQAVPLSARKSSGVSSEGISPFLQLPHFSDAVVKKIARKKVKSFQDLQEMRLEDRSELLTQVAGLSATDVEDIEKVLEMMPSITVDITCETEGEEGIQEGDIVTLQAWVTLKRPNGLVGALPHAPYFPFHKEENYWVLLADSVSNNVWFSQKVSFLDEGGAITAASKAISESMEGSGAGVKETNDAVREAIEKVKGGSRLVMGKLQAPAEGTYNLTCFCLCDTWIGCDKKQALKVKVLKRTRAGTRGLVSDEGAIAEEGMEEEDEIEEEDYDDDYESEYSEDEDEKKDMDEKRGSKKANGSVKQKKESSSEESGSEEE
Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
Q0WT48
B9E1I7
CODY_CLOK1
GTP-sensing transcriptional pleiotropic repressor CodY
Clostridium
MSTLLDKTRKLNKILQKSGVEPVVFDDICKILSEVLGCNVYVISRKGKVLGYNFPDGFECSTVKNKIISEMRFPEQYNNKLLNAHETLPNLSNHGICVFEDGTPCDLEDKVTTIVPIIGNRERLGTLLLASFGEKFTDEDLVLGEYSATIVGLEILKSKNDEIEEEARKKAVVQLAIGTLSYSELEAVEHIFNELDGKEGLLVASKIADKVGITRSVIVNALRKFESAGVIESRSLGMKGTHIKILNDKLLDELKKIK
DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor.
B9E1I7
B4ER10
IFNL3_CHICK
Interleukin-28B
Gallus
MVCYGVTIILVGTLGSLLVGAFPQVTPKKSCSLSKYQFPAPLELKAVWRMKEQFEDIMLLTNRKCNTRLFHRKWDIAELSVPDRITLVEAELDLTITVLTNPTTQRLAETCQQPLAFLTQVQEDLRDCLALEAPSHQPSGKLRHWLQKLKTAKKKETAGCLEASAILHIFQVLNDLRCAAQREDCT
Cytokine which plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exhibits antiviral activity against the H5N1 influenza A virus. Induces the expression of the antiviral MX protein in epithelial-rich tissues, such as intestine, trachea and lung.
B4ER10
B0KHR5
TRMA_PSEPG
tmRNA (uracil(341)-C(5))-methyltransferase
Pseudomonas
MSAAFDPSSYATQLDAKVARLRELLAPFGAPEPAVFDSPREHYRLRAEFRLWREDGQRHYAMFAQGDKHKAILIDDFPIASQRINALMPRLKAAWQASEELGNRLFQVEFLTTLAGDAMITMCYHRPLDEAWEVEARQLAEALGVSVIGRSKGKRLVIGRDYAIEELDVAGRVFSYRQPEGAFTQPNGAVNQKMLSWAFEAIGEREDDLLELYCGNGNFTLPLATRVRQVLATEISKTSVNAALSNLDENAVDNVRLVRLSAEELTQALNEVRPFRRLEGIDLKSYEFGTVFVDPPRAGMDPDTCELTRRFERILYISCNPETLAANIAQLQDTHRIERCALFDQFPYTHHMESGVLLVRR
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
B0KHR5
Q6K4N0
RSZ21_ORYSJ
RS-containing zinc finger protein 21
Oryza sativa
MARLYVGNLDPRVTSGELEDEFRVFGVLRSVWVARKPPGFAFIDFDDKRDAEDALRDLDGKNGWRVELSRNSSSRGGRDRHGGSEMKCYECGETGHFARECRLRIGPGGLGSGKRRSRSRSRSRSPQYRKSPTYGRRSYSPRDRSPRRRSVSPVRGRSYSRSPRGRGGSPYADGRDGGRYRRSRS
Involved in pre-mRNA splicing.
Q6K4N0
B4SG10
RPOC_PELPB
Transcriptase subunit beta'
Pelodictyon
MIFSQGASPLKGEFSRIKFSIASPESILAHSRGEVLKPETINYRTFKPERDGLMCEKIFGPTKDWECYCGKYKRVRYKGIICDRCGVEVTTKSVRRERMGHIALAVPVVHTWFFRSVPSKIGALLDLSTKELERIIYYEVYVVINPGEPGEKQGIKKLDRLTEEQYFQIITEYEDNQDLEDSDPDKFVAKMGGEAIHMLLKNIDLDASAIHLRKVLKESNSEQKRADALKRLKVVEAFRKSYEPHKKTRKKPQGLFPEDELPEPYVYEGNKPEYMVMEVVPVIPPELRPLVPLEGGRFATSDLNDLYRRVIIRNNRLKKLIDIRAPEVILRNEKRMLQEAVDALFDNSRKANAVKTGESNRPLKSLSDALKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHECGLPKSMAIELFQPFVIRRLVDRGIAKSVKSAKKLIDKKDPIVWDVLEKVIDGRPVLLNRAPTLHRLGIQAFQPLLIEGKAIQIHPLVCTAFNADFDGDQMAVHIPLSQEAQLEASLLMLSSHNLILPQSGKPVTVPSQDMVLGMYYLTKSRSRDLGEGQIFYSPQDVLIAYNEERVGLHAQIFVQYDGEIDQKFDSLRVLDTMTDLTAEKSAWLKAQIEKKCILLTTVGRVIFNQNVPKEIGFINRVIDKKVAKELIGRLSSEVGNVETAKFLDNIKEVGFHYAMKGGLSVGLSDAIVPETKARHIKSAQRDSTKVVKEYNRGTLTDNERYNQIVDVWQKTSNIVAEESYQKLKKDRDGFNPLYMMLDSGARGSREQVRQLTGMRGLIARPQKSMSGQPGEIIENPIISNLKEGLTVLEYFISTHGARKGLSDTSLKTADAGYLTRRLHDVAQDVIVTIDDCGTTRGLYVHRNIEEETSGQIKFREKIKGRVAARDIIDTLNNNVIVNSGEIITEELAELIQETAGVEEAEIRSVLTCESKIGICSKCYGTNLSVHELVEIGEAVGVIAAQSIGEPGTQLTLRTFHQGGTAQGGISETETKAFYDGQIQFEDIKTVEHTAINEDGVADLRIIVIQKNGKINIADPESGKILKRYLVPHGAHLHCKNGSLVKKDQVMFSSEPNSTQIIAEIPGIIKFADIEKGITYKEEVDPQTGFSQHTIINWRSKLRATETREPRLMIIDASGEVRKTYPVPIKSNLYVEDGQKVEPGDIMAKVPRNLDRVGGDITAGLPKVTELFEARIPTDPAIVTEIDGYVSFGSQRRSSKEIKVKNDFGEEKVYYVQVGKHVLANEGDEVKAGDPLTDGAVSPQDILRIQGPNAVQQYLVNEIQKVYQINAGVEINDKHLEVIVRQMLQKVRVEEPGDTDLLPGDLIDRSAFVESNQSVAEKVRITEKGDAPARIQDSQLHKVRDITKLNRELRKNSKNMIAFEPALQATSHPVLLGITSAALQTESVISAASFQETTKVLTDAAVAGKVDYLAGLKENVIVGKLIPAGTGLKRYKAIKLTGEGQESNATERVVEEPATREGFANER
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B4SG10
A9A3X2
RNZ_NITMS
tRNase Z
Nitrosopumilus
MKLVFLGTSAAQPTENRGLSCICLEREGEVLMFDAGEAAQISYMKSGLGWNKKMKIFVTHLHGDHCVGILGLLQTMSMQNRTESLEIFGPSGIEEFIAANIKVLNFGLSFPILINTIKDEKIFEDEKFLIRTCKANHSIIAFSYLFEEKDKPGRFNVEKAKELGIPEGELWNKLQNGNEITVNEKIIKPEQVLGERRPGKKIGISGDTMPTKELEEFFEECDYLVFDSTFLEAEKQKAQDTCHSTAKQAATVAKNAKVKNLVLTHFSARYRDEVEHLREAKEIHDSVITAKDLLEIEIK
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
A9A3X2
Q2JIF9
ATPD_SYNJB
F-type ATPase subunit delta
unclassified Synechococcus
MISSTMAEKVVDPYAEALIALGSGQGLLDTFAADMRFIAEVLRATPELGQFLANPVIKAEAKKNLLQQVFADQIHPLLLNALKLLTDRRRIMFLGTVCRRFLDLQRKLQNIVLAEVTTAIPLTEAQQQSIRERVMDFTQASGVELQATQDPELLGGVVIKIGSQVIDLSLRGQLRRLALQLA
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Q2JIF9
Q7MAE8
PYRF_WOLSU
OMP decarboxylase
Wolinella
MQLCIALDLPSQEENLKLLESLVGLPVWIKVGLRSYIRDGKEFLGRIRQIDPRFELFLDLKLHDIPNTMGDAAEEIASLGVGMFTLHASSGGEAMREVAARLARFPRRPLAFAVTALTSFGEEGFREIYNASLESKALDMAMLAAQNGMDGVVCSVFESQRIKSYVAQDFLTLTPGIRPFGEPSGDQKRVADLHEAKSASSDFIVVGRPVYKHPRPREAVEKILEGIA
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Q7MAE8
A5I7K8
EFTU_CLOBH
Elongation factor Tu
Clostridium
MAKAKFERSKPHVNIGTIGHVDHGKTTLTAAITTVLAQKGGASATKYDEIDKAPEEKERGITINTSHVEYETANRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLASRVGVQYIVVFLNKADQVDDPELIELVEMEVRELLNEYGFPGDDTPIVVGSALEVLENQDNAEKTKCIDELMEAIDSYIPTPERATDQPFLMPVEDVFTITGRGTVATGRVERGVLHTGDEVELIGMKQEVSKTVCTGIEMFRKILDEAMAGDNIGALLRGIQRDEIQRGQVLAKPGSVTPHKKFVGQVYVLKKEEGGRHTPFFNGYRPQFYFRTTDVTGSINLPEGVEMVMPGDHIDMAVELITPVAMHENLRFAIREGGRTVGSGVVTTISE
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
A5I7K8
A4SSZ3
RS14_AERS4
30S ribosomal protein S14
Aeromonas
MAKTSMKAREAKRAKLVAKFATKRTELKAIIVDMNASEEARWDAVLQLQQLPRDSSPSRQRNRCNITGRPHGFLRKFGLSRIKVREHAMKGEIPGLKKASW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
A4SSZ3
Q1ICK1
ZIPA_PSEE4
Cell division protein ZipA
Pseudomonas
MEIGLREWLILIGIIVIAGILFDGWRRMRGGKGKLKFRLDRSYANAPDDEGGAEVLGPSRVLETHKEPELDESDLPSVSAPARERERDPKPAKASKRGKRNHSEPQQGDLNLAAEAREPDLFADDKDDFVADNNRHGAAATPSTPVKELPPAEEVLVISVISRDEGGFKGPALLQNILESGLRFGEMDIFHRHESMAGHGEVLFSMANAVKPGVFDLDDIDHFSTRAVSFFLGLPGPRHPKQAFDVMVAAARKLAHELDGELKDDQRSVLTAQTIEHYRQRIVEFERRALTQKR
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
Q1ICK1
Q2RXI5
GUAA_RHORT
Glutamine amidotransferase
Rhodospirillum
MTDRTSVSATDRILIIDFGSQVTQLIARRVRESGVYSEIQPFNTVTAASIAAFAPKGVILSGGPASVTAADTPRAPIELFTMGLPVLGICYGQQTMVAQLGGRVEAPDHREFGRAFVEVTAGCALFDGVWTPGERDQVWMSHGDRVDAIPEGFSVVAVSEGAPYAAIADEARHFYGVQFHPEVVHTPKGAALLRNFTHGICGCGGDWTMAAFKDQAIARVREQVGSGRVICGLSGGVDSSVVAALIHEAIGEQLVCVLVDHGMMRQGETEQVVRVFRDRFNITLVHRDASELFLGKLDGVVDPEAKRKIIGATFIDVFDEEARKVGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMKMALVEPLRELFKDEVRDLGRELGLPDEMVGRHPFPGPGLAIRIPGQPLTREKLDILRRADAIYLEEIRNAGLYDVIWQAFAVLLPVRTVGVMGDARSYDFALALRAVTSTDGMTADYYPFDHTFLGRVANRIINEVKGVNRVVYDITSKPPGTIEWE
Catalyzes the synthesis of GMP from XMP.
Q2RXI5
Q03FS2
RBFA_PEDPA
Ribosome-binding factor A
Pediococcus
MARQYRSDRLSQEIEKEVSDILRRRVRDPRVEGVTITGVDVTGDLQQAKIYYSILSDKASDDQKTKAGLEKASGLIRKELGSRLSIYKTPELSFIRDESVQYGDKIDQLLNKLNRD
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
Q03FS2
Q9Z856
DAPAT_CHLPN
LL-diaminopimelate aminotransferase
Chlamydia
MRRNPHFSLLKPQYLFSEISKKLAQFRKENPEISVIDLSIGDTTQPLCRSITQAIKEFCVSQEKQETYRGYGPETGLEKLRTKIASEVYENRISPEEIFISDGAKPDIFRLFSFFGSEKTLGLQDPVYPAYRDIAHITGIRDIIPLACRKETGFIPELPNQQSLDILCLCYPNNPTGTVLTFQQLQALVNYANQHGTVLIFDAAYSAFVSDPSLPKSIFEIPEAKYCAIEINSFSKSLGFTGMRLAWNVIPKELTYDNNEPMINDWKRLFATTFNGASLLMQEAGYYGLDLFPTPPAISLYLTNAQKLKKSLETAGFSVHGGDHAPYLWVELPEGISDEEAFDFFLHQYHIAVTPGHGFGSCGQGFVRFSALTQPQNIALACDRLCTASLKETMVLA
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
Q9Z856