accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
A5FSU1
SYA_DEHMB
Alanyl-tRNA synthetase
Dehalococcoides
MFSSDELRENYLKFFEEKGHKRIASSSLIPHNDPTLLLTTAGMVQFKPYYLGVAKPENPRMASCQKCFRTTDIESVGDASHLTMFEMLGNFSIGNYFKKEAIAWAWEYVTQRLNIPAERLWITVYLDDDEAIALWKEQGVPENRIVRLGAADNFWGPAGDSGPCGPCSEIHYDFGQETGCGKADCNPSCKCGRFCEIWNLVFVQFNQDKSGKRQNLPAPSIDTGMGLERLTILMQSKKNVYETDIFAPIVEKACLLSGRKYGCDAATDRALRIVSEHSRGITFLIADGVIPDKAGRGYVLRRLLRRAVLFGRRLGLERPFLVDMAGAVINRMSGIYPELKKRQTYVLEMIASEEARFSETLATGLELLEEIVRQTKGGRISGQDAFKLYDTYGFPVEMTTEIAAEKGLSVDLDGFESEMEIQRTKARSSRKFSFDAAATAEAVKNMRHAEKTCFVGYELAIQKSTIKDILTEGGTVDSIEEGDEASIVLDESPFYAEMGGQVGDTGEIITDAGRFEVKNTLHLPNGVFLHQGRVINGCLKISEAATAHINEERRRDIARNHTATHILQTALREVLGEQVQQRGSVVTPDRLRFDFSHLKPMSKDEMRRVEEFVNDKIRRNLPVYAEEMPYRHALEEGVTALFGEKYGDRVRVLRVGRPAVSAELCGGTHVTASGEIALFKIMSESSVGAGLRRIEAVTGREAEAFINLQQDSLSELSGMLESTAEESPRKLAELKEEIDTLKKAVQNLERQMSRGEAEELLSKAEDYKGVKLLVSRMTSVNADTLRETADFLRDKLGSGVIVLGTVTEDKPFFLCMVTPDLIAKGYHAGNIVKKLSQIAGGGGGGKPNMAQGGGRDKSKLDEALQAVKGMI
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
A5FSU1
O29995
CDC61_ARCFU
ORC1-type DNA replication protein 1
Archaeoglobus
MNIFDNILSSATIFKNRDVLRHSYTPEKLPHREEQINQLALLLSPMLRGGTPSNIFIYGKTGTGKTATVLFVARQLEEASRKAKLNVAVHYINCEIVDTAYRVLASLARKFGSNVPMTGWPTDQVYEEVKKALERRGTRVVVILDEIDKLVKKAEEALYGLTRINSELENSSICIVGISNNLKFKEYLDARILSSLSEEEIVFPPYNAEQLEDILQQRAKLAFEDGVLEDGVIQLCAAIAAQEHGDARKALDLLRVSAEIAERERDSMVRVEHVKKAVRKIETDYMIETVRTLPVHSKILLYSMSLISENSPKFTTGEVYCVYKKLCGKVGVDPLTQRRISDLISELDMLGILNSVVISKGRYGRTREMKLEADEKVLRKALEEDYRLQNLRKFEGELKKLANLNLFQF
Involved in regulation of DNA replication.
O29995
Q211T9
MURC_RHOPB
UDP-N-acetylmuramoyl-L-alanine synthetase
Rhodopseudomonas
MRLPREIGPIHFVGIGGIGMSGIAEVLCNLGYTVQGSDASEGANVSRLRDKGIAIHVGHQAENVAGADVVVVSTAIKRDNPELLAARAQRIPVVRRAEMLAELMRLKSCVAIAGTHGKTTTTSMVAALLDAGEFDPTVINGGIINAYGTNARLGAGEWMVVEADESDGTFLKLPADVAIVTNVDPEHLDHFKTFDAVQEAFRDFVENVPFYGFAVMCIDHPVVQALVGKIEDRRIITYGENPQADVRLLDLTPNGGSSAFRVAFRDRKAGTAHEIADLVLPMPGRHNALNATAAIAVAHELGLSDDTIRKALAGFGGVRRRFTKTGEWNGVTIIDDYGHHPVEIAAVLKAARESTKGKVIAVVQPHRFTRLQSLFEEFCTCFNDADVVVVAEVYPAGEAPIEGVDRDHFVLGLRAHGHREVIPLQESAALASVVYGAAHSGDYVVCLGAGNITQWAYALPGELKALD
Cell wall formation.
Q211T9
Q6G8L2
THII_STAAS
tRNA 4-thiouridine synthase
Staphylococcus
MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAMSAAAIKFAQQFEENSTFKIDVKRADKNFPMDTYELQRELGGAILKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Q6G8L2
B2KWI0
RTA1_AJECA
Siderophore biosynthesis cluster protein RTA1
Histoplasma
MSPESKKITAHGSTSMPLSRTSKPQKFTIPLTVGAIFSVIGFLQRFFLASGKGDVQSLYTLSTMFILGAGPTYAGADYFICGRLFSFVPSAAPMSPIRVVRTFITFDVLAEVCVWTGAGLLAGAHTDTAARYKIGLNLIRAAMITQAFLFTSFVAILASFHVRVCALRAEWSVTSNGGTGRRFMMVVHSLYASSIFIIIRSAYHIAGHSFRTNEQPFLICEASLMLLNTAMFNVFHPGHILPIDSRVYVGIDGQERANETIEGAFTDSRPLLQKILDPLDVKGLFSRDKKRWHDPTAELEMDINSTLYAALT
Lipid-translocating exporter-like protein; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence via intracellular iron acquisition during macrophage infection .
B2KWI0
B8E2U4
GATC_DICTD
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Dictyoglomus
MEKRDFKEQLKKTAHLARLYLTPEEEELYAKQLQDILDYFKKLQEVDTSNIEPMAHVLSLSNIWREDEPKGSISQEEAFKNAPEIENLGFKIPRIIKREE
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
B8E2U4
Q28UX7
RPOB_JANSC
Transcriptase subunit beta
unclassified Jannaschia
MPQTYAGQKRIRKFYGKIREVLEMPNLIEVQKSSYDLFLKSGDQLEPMDGEGIKGVFQSVFPIKDFNETAILEFVKYELETPKFDVEECQQRDLTYAAPLKVTLRLIVFDIDEDTGAKSVKDIKEQDVFMGDMPLMTPNGTFVVNGTERVIVSQMHRSPGVFFDHDKGKTHSSGKLLFACRIIPYRGSWLDFEFDAKDIVFSRIDRRRKLPVTTLLYALGLDQEGIMDAYYDTVTFKMVKNKGWSTKFFPERVRGTRPTTDLVDAKTGEVIAEAGKKVTPRAVKKWIDEGSIENLLVPFDGIVGRFAAKDIINEETGAIYVEAGDELTWELDKAGEVSGGTLKELIDAGITEIPVLDIDNVNVGPYMRNTLAVDKNLNRESALMDIYRVMRPGEPPTVEAASNLFDQLFFDSERYDLSAVGRVKMNMRLDLDAEDTMRTLRKEDIISCIKALVELRDGRGDIDDIDHLGNRRVRSVGELMENQYRVGLLRMERAIKERMSSVEIDTVMPQDLINAKPAAAAVREFFGSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRMCPIETPEGPNIGLINSLATYARVNKYGFIETPYRRVNDAVVSDDVVYMSATEEMRHTVAQANANLDDDGKFVNDMVNTRMSGEYTLNPREAIDLIDVSPKQLVSVAASLIPFLENDDANRALMGSNMQRQAVPLLQADAPFVGTGIESVVAKDSGAAIMAKRGGVIDQVDAQRIVIRATEDLELGDAGVDIYRLRKFQRSNQNTCINQRPLVKVGDKIGKGEVIADGPSTDIGELALGKNVIVAFMPWNGYNYEDSILISERISRDDVFTSIHIEEFEVAARDTKLGPEEITRDIPNVGEEALRNLDEAGIVYIGAEVEPGDILVGKITPKGESPMTPEEKLLRAIFGEKASDVRDTSLRVKPGDYGTIVEVRVFNRHGVEKDERALQIEREEVERLARDRDDELVILERNIYARLRGMIMGKTAVKGPKGVKPNTVIDEDLLDGQLSRGQWWQLALEDEKDAAHIEALNQQFDTQKRALDHRFEDKVEKVRRGDDLPPGVMKMVKVFIAVKRKLQPGDKMAGRHGNKGVISKVVPMEDMPFLADGTPVDFVLNPLGVPSRMNVGQILETHMGWAARGMGLQIDEALDEYRRSGDMTPVRDALKIAYGDDVYDDAFADRDEESLLEAAGNVTKGVPIATPVFDGAKEADVNDALIRAGFSTSGQSKLFDGRTGEQFAREVTVGVKYLLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVAGRTKVYESIVKGEDNFEAGVPESFNVLVKEVRGLGLNMELLDAEDDEGGIAAE
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q28UX7
A2BH40
ARI1A_MOUSE
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
Mus
MAAQVAPAAASSLGNPPPPPSELKKAEQQQREEAGGEAAAAAAERGEMKAAAGQESEGPAVGPPQPLGKELQDGAESNGGGGGGGAGSGGGPGAEPDLKNSNGNAGPRPALNNNLPEPPGGGGGGGSSSSDGVGAPPHSAAAALPPPAYGFGQAYGRSPSAVAAAAAAVFHQQHGGQQSPGLAALQSGGGGGLEPYAGPQQNSHDHGFPNHQYNSYYPNRSAYPPPPQAYALSSPRGGTPGSGAAAAAGSKPPPSSSASASSSSSSFAQQRFGAMGGGGPSAAGGGTPQPTATPTLNQLLTSPSSARGYQGYPGGDYGGGPQDGGAGKGPADMASQCWGAAAAAAAAAAAVSGGAQQRSHHAPMSPGSSGGGGQPLARTPQSSSPMDQMGKMRPQPYGGTNPYSQQQGPPSGPQQGHGYPGQPYGSQTPQRYPMTMQGRAQSAMGSLSYAQQIPPYGQQGPSAYGQQGQTPYYNQQSPHPQQQPPYAQQPPSQTPHAQPSYQQQPQTQQPQLQSSQPPYSQQPSQPPHQQSPTPYPSQQSTTQQHPQSQPPYSQPQAQSPYQQQQPQQPASSSLSQQAAYPQPQPQQSQQTAYSQQRFPPPQELSQDSFGSQASSAPSMTSSKGGQEDMNLSLQSRPSSLPDLSGSIDDLPMGTEGALSPGVSTSGISSSQGEQSNPAQSPFSPHTSPHLPGIRGPSPSPVGSPASVAQSRSGPLSPAAVPGNQMPPRPPSGQSDSIMHPSMNQSSIAQDRGYMQRNPQMPQYTSPQPGSALSPRQPSGGQMHSGVGSYQQNSMGSYGPQGSQYGPQGGYPRQPNYNALPNANYPNAGMAGSMNPMGAGGQMHGQPGIPPYGTLPPGRMAHASMGNRPYGPNMANMPPQVGSGMCPPPGGMNRKTQESAVAMHVAANSIQNRPPGYPNMNQGGMMGTGPPYGQGINSMAGMINPQGPPYPMGGTMANNSAGMAASPEMMGLGDVKLTPATKMNNKADGTPKTESKSKKSSSSTTTNEKITKLYELGGEPERKMWVDRYLAFTEEKAMGMTNLPAVGRKPLDLYRLYVSVKEIGGLTQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQCLYAFECKIERGEDPPPDIFAAADSKKSQPKIQPPSPAGSGSMQGPQTPQSTSSSMAEGGDLKPPTPASTPHSQIPPLPGMSRSNSVGIQDAFPDGSDPTFQKRNSMTPNPGYQPSMNTSDMMGRMSYEPNKDPYGSMRKAPGSDPFMSSGQGPNGGMGDPYSRAAGPGLGSVAMGPRQHYPYGGPYDRVRTEPGIGPEGNMGTGAPQPNLMPSTPDSGMYSPSRYPPQQQQQQQQQHDSYGNQFSTQGTPSSSPFPSQQTTMYQQQQQNYKRPMDGTYGPPAKRHEGEMYSVPYSAGQGQPQQQQLPAAQSQPASQPQAAQPSPQQDVYNQYSNAYPASATAATDRRPAGGPQNQFPFQFGRDRVSAPPGSSAQQNMPPQMMGGPIQASAEVAQQGTMWQGRNDMTYNYANRQNTGSATQGPAYHGVNRTDEMLHTDQRANHEGPWPSHGTRQPPYGPSAPVPPMTRPPPSNYQPPPSMPNHIPQVSSPAPLPRPMENRTSPSKSPFLHSGMKMQKAGPPVPASHIAPTPVQPPMIRRDITFPPGSVEATQPVLKQRRRLTMKDIGTPEAWRVMMSLKSGLLAESTWALDTINILLYDDNSIMTFNLSQLPGLLELLVEYFRRCLIEIFGILKEYEVGDPGQRTLLDPGRFTKVYSPAHTEEEEEEHLDPKLEEEEEEGVGNDEEMAFLGKDKPSSENNEEKLVSKFDKLPVKIVQRNDPFVVDCSDKLGRVQEFDSGLLHWRIGGGDTTEHIQTHFESKIELLPSRPYVPCPTPPRKHLTTVEGTPGTTEQEGPPPDGLPEKRITATMDDMLSTRSSTLTDEGAKSAEATKESSKFPFGISPAQSHRNIKILEDEPHSKDETPLCTLLDWQDSLAKRCVCVSNTIRSLSFVPGNDFEMSKHPGLLLILGKLILLHHKHPERKQAPLTYEKEEEQDQGVSCDKVEWWWDCLEMLRENTLVTLANISGQLDLSPYPESICLPVLDGLLHWAVCPSAEAQDPFSTLGPNAVLSPQRLVLETLSKLSIQDNNVDLILATPPFSRLEKLYSTMVRFLSDRKNPVCREMAVVLLANLAQGDSLAARAIAVQKGSIGNLLGFLEDSLAATQFQQSQASLLHMQNPPFEPTSVDMMRRAARALLALAKVDENHSEFTLYESRLLDISVSPLMNSLVSQVICDVLFLIGQS
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically . Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth .
A2BH40
B4ECL8
LPXB_BURCJ
Lipid-A-disaccharide synthase
Burkholderia cepacia complex
MPLPTNQLRLAMVAGEPSGDLLAASLLGGLRERLPESAQYYGIGGQRMIAQGFDSHWQMDKLTVRGYVEALGQIPEILRIRGELKRQLLAERPDAFIGVDAPDFNFSVEQAARDAGIPSIHFVCPSIWAWRGGRIKKIAKSVDHMLCLFPFEPAILDKAGVASTYVGHPLADDIPLEPDTHGARIALGLPADGPVIAVLPGSRRSEIALIGPTFFAAMALMQQREPGVRFVMPAATPALRELLQPLVDAHPQLALTITDGRSQVAMTAADAILVKSGTVTLEAALLKKPMVISYKVPWLTGQIMRRQGYLPYVGLPNILAGRFVVPELLQHFATPEALADATLTQLRDDANRRTLTEVFTEMHLSLRQNTAAKAAEAVVRVLEQRKGRA
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
B4ECL8
Q92GT4
FPG_RICCN
DNA-(apurinic or apyrimidinic site) lyase MutM
spotted fever group
MPELPEVETLKNSLKDKLIGLIIENVELKRDNLRYKLSPLLATETLNTNILDVRRRAKYLIIDFNNDYSLIVHLGMSGRFTLQSANYKTQKHDHVIFDLSNGEKLIFNDTRRFGMIYSFKTDLLEKEFLNDLGIEPFSDLLTLEYLKDKLQTKKIPIKNLIMDNRVIVGVGNIYASESLHLARIHPDKSGNNLRDDEIENLIKAIRDVLTKAITAGGTTLKDFVNGDNKPGYFTKQLKVYGREGQSCLSCSSTIIKIKHSGRSTFYCKTCQYS
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Q92GT4
Q3J803
HFQ_NITOC
RNA-binding protein Hfq
Nitrosococcus
MSRGQSLQDPFLNALRKERVPVSIYLVNGIKLQGQIESFDQFVVLLKNSVSQMVYKHAISTVVPARNVKLSSNEGENIHPIGGTRSADAD
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
Q3J803
A0JZ73
RL24_ARTS2
50S ribosomal protein L24
Arthrobacter
MAKIKKGDLVQVITGAKAERGGDRGKQGKVLRVFPDTNRVLVEGINRVTKHTKVGQSQRGTKTGGIEVVEASIHISNVALVDPSTKKPTRVGFRTETVERNGKKREVRVRVAKSSGKDI
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
A0JZ73
A8AHC4
CHBG_CITK8
Chitotriose-6P deacetylase
Citrobacter
MERLLIVNADDFGLSKGQNYGIVEACRNGVVTSTTALVNGDAIDHAAQLCRDVPKLAVGMHFVLTLGKPLTAMPGLTREGLLGKWIWQMAEEETLPLDEISHELECQYQRFIDLFGREPTHLDSHHHVHMFPQIFPIVAMFAAERGVALRIDRQSVLNADDLPVALRSSQGFSSEFYGDAISEALFLQVLDASADRGEKSLEVMCHPAFIDNIIRQSAYCYPRLTELDVLTSASLKYAIAERGYRLGSFLDV
Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF.
A8AHC4
Q8KCS5
PURQ_CHLTE
Phosphoribosylformylglycinamidine synthase subunit I
Chlorobaculum
MADVTVGIVVFPGSNCDHDTEYAVASFPGVKPVMLWHNDHDLKGCDAVILPGGFSYGDYLRCGAIARFSPIMREVIDFAGKGRPVLGICNGFQVLVECGLLEGALIRNAGRRFVSRQTTISVANNATIFTDRYQKGEVLRVPVAHGEGNYYASPETIESLESNGQVVFRYTDAWGNATAEANFNGSMNNIAGIVNKQGNVLGLMPHPERASEKLLGSEDGRRLFESLFAHLAGA
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
Q8KCS5
A8LQ63
DNAJ_DINSH
Chaperone protein DnaJ
Dinoroseobacter
MAKRDYYDVLGVSKGASPDEIKKGFRKKAKELHPDRNSDNPNAEAQFKEANEAYDILKDPDKKAAYDRYGHAAFENGSGGPRGPGGFGGQGQGDFASAFSDVFEDLFGDFMGGQRGGGRQRAARGSDLRYNLRITLEQAFMGMQKTISVPGTVSCSACEGTGAEGGAEPVVCPTCSGMGKVRAQQGFFTIEKTCPTCSGMGQIIKNPCQACRGAGREEKTRALSVNIPAGVETGTRIRLAGEGDAGVRGGPSGDLYIFIEVEEHRIFQREGLDLYCRVPVSMTSAALGGDVEVPTIEGGRSRVKIPSGSQSGRQMRLRGKGMPALRGAGTGDMFIELAVETPVNLTMRQRELLREFEAESQDNQPETSKFFKTVKSFWDGMKS
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
A8LQ63
A1SJ61
RECA_NOCSJ
Recombinase A
Nocardioides
MAGGDREKALDAALANIEKQFGKGSVMRLGDEVRAPLEIIPSGSIALDVALGLGGFPRGRVVEIYGPESSGKTTVALHAVANAQRAGGIVAFIDAEHALDPDYAKNLGVDTDALLVSQPDSGEQALEIADMLIRSGALDLIVIDSVAALVPRAEIEGEMGDSHVGLQARLMSQALRKMTGALNNSKTTMIFINQLREKIGVMFGSPETTTGGKALKFYASVRLDVRRIETLKDGTDMVGNRTRVKVVKNKVAPPFKQAEFDIMYGKGISREGGLIDVGVEAGLVRKAGAWYTYEGDQLGQGKENARAFLRDNPDLANELEKKILEKLGVGPTVDQDVAELPAEPIGVGDF
Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
A1SJ61
Q5PKW4
PSTB_SALPA
Phosphate-transporting ATPase
Salmonella
MSMVETAPSKIQVRDLNFYYGKFHALKNINLDIAKNQVTAFIGPSGCGKSTLLRTFNKMYSLYPEQRAEGEILLDGDNILTNTQDIALLRAKVGMVFQKPTPFPMSIYDNIAFGVRLFEKLSRADMDERVQWALTKAALWNETKDKLHQSGYSLSGGQQQRLCIARGIAIRPEVLLLDEPCSALDPISTGRIEELITELKQDYTVVIVTHNMQQAARCSDHTAFMYLGELIEFSNTDDLFTKPAKKQTEDYITGRYG
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
Q5PKW4
G0S7R3
POM34_CHATD
Pore membrane protein of 34 kDa
Thermochaetoides
MSSTLSVAKAASTPVKQITSAVGPVKESPGNWKHPRLAEITRRQSRNIFGEKNVRQIVYNVAAIVLLEIFRVFASPSIPSQLILPSLRPYSLWIHAVFLVIPLTNIVIALLPLFRPVDDLSDIPLTPAQRKLLGLPPSSKPATPNSVYSTPPRYSRTPSLAGSPASIKSYTSSTLPTASSPTPGAAGIGAGSPAAPIYLSPSKFTTSTSSQQFSPSPSGASPLLHRAISNTSTASGVSPYGSPNSPSKFGASTNSTLAASTISTSTFSVSTTSSIAHVLNNSRLRESVIEGVPATPTPVGKGASVKANSKWLYQRGRRTSSNNWVY
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors.
G0S7R3
A3DJE9
HISZ_ACET2
ATP phosphoribosyltransferase regulatory subunit
Acetivibrio
MAEWKIYTPEGVQDILQNECFFKKNLEDRIRKVFRASGYYEVETPIVEFYDVFSTEENIIPQETMFKFFDQQGRILVLRPDLTIPIARVAATKLKDAAYPLRISYIGNAFKYNELGGGKQKEFTQAGVEIIGVNTPEADAEVIATAIDAVKATGLENFQIDIGQVEFFKGLMEETGLSEEETEKMRVLIDRKDFLGIEELVEEHNIRDDLKELILDFPKLFGSTDVIDRVEKYPINERSIKALNNLRSIINILDDYGLSKYVSVDLGMVQSLNYYSGTIFRGFTYGVGFPILSGGRYDRLVEKFGKSSPATGFSMGINMVMMALDRQKVEFEKPRVDTLVCYREEGRKTAFQICETLRKQGLAVEVDINGGDFETARNYAALKGIGGILKVLDDENIEIHNLEKGEVSKVTISELLKA
Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.
A3DJE9
Q03QX7
RF1_LEVBA
Peptide chain release factor 1
Levilactobacillus
MDEMFDKLQAVADRYDELNELISDPEVIADTQRFMALSKEEGELRETVDKYHQYQDVTQQIADDDEMLHDKLDADMESMIKDELKELTAQKAALEEDIKVLLLPKDPNDDKNIIMEIHGAAGGDEASLFAADLFSMYSKYAERQGWQIEVVDENATEVGGFKEIVMMITGNKVYSKLKYENGAHRVQRVPVTESAGRVHTSTATVGVMPEEEDVDIDIDPKDIRTDVYRSSGAGGQHINKTSSAVRMTHLPTGIVVAMQDERSQQQNRAKAMQILRARVYDYYKQQEESAYNAERKSAVGTGDRSERIRTYNYPQNRVTDHRIGLTLNKLDRIMNGELDDIIDALIVSDQAAKLEDLKNNG
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
Q03QX7
Q8RFV0
LOLD_FUSNN
Lipoprotein-releasing system ATP-binding protein LolD
Fusobacterium
MKMWRHLDMNNIIMKLEDIDKFYMETGNKLHILRKLNLEVKRGEFVSILGKSGSGKSTLLNIMGLLDKIDGGKIWIDDKEVSSLNEMERNNIKNHFLGFVFQFHYLMSEFTALENVMIPALLNNFKNKTEIEKEAKELLEIVGLAERMKHKPNQLSGGEKQRVAIARAMINKPKLILADEPTGNLDEDTGELIFSLFRKINKEHNQSIVVVTHARDLSQVTDRQIFLKKGVLE
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
Q8RFV0
P37887
CYSK_BACSU
Superoxide-inducible protein 11
Bacillus
MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSVKDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSMERRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGKEIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGPHKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAALQVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD
Catalyzes the conversion of O-acetylserine to cysteine. Also acts as a sensor of cysteine availability in the signal transduction pathway modulating CymR activity. When cysteine is present, the pool of O-acetylserine (OAS) is low, which leads to the formation of a CymR-CysK complex and transcriptional repression of the CymR regulon occurs. In the absence of cysteine, the OAS pool is high and the CymR-CysK complex is mostly dissociated, leading to a faster dissociation of CymR from its DNA targets and the lifting of CymR-dependent repression.
P37887
B3PP95
SECA_RHIE6
Protein translocase subunit SecA
Rhizobium
MVSFGGIARKLFGSSNDRRVRSFQPNVTAINSIEEKTKALTDEQLAAKTAEFRALLAEGKTLDDILIPAFAVVREASRRVLDLRPFDVQLIGGMILHSNAIAEMKTGEGKTLVATLPVYLNALSGKGVHVVTVNDYLAQRDAATMGRVYGFLGMTTGVIVHGLSDEERRAAYACDITYATNNELGFDYLRDNMKYEKNQMVQRGHNFAIVDEVDSILVDEARTPLIISGPLDDRSELYNTIDAFIPLLVPSDYEIDEKQRSANFSEEGTEKLENMLRQAGLLKGNALYDIENVAIVHHINNALKAHKLFQRDKDYIVRNGEVVIIDEFTGRMMPGRRYSEGQHQALEAKEKVQIQPENQTLASITFQNYFRMYDKLAGMTGTAQTEAEEFGNIYNLDVIEVPTNLPIKRIDEDDEVYRTFDEKFKAIIEEILDAHKRGQPVLVGTTSIEKSELLAERLRKQGFNDFQVLNARYHEQEAYIVAQAGVPGAVTIATNMAGRGTDIQLGGNLEMRIERELGEIEAGPEREARIQAIVEEIKELKQKALTAGGLYVIATERHESRRIDNQLRGRSGRQGDPGRSKFYLSLQDDLMRIFGSDRMDSMLTKLGLKEGEAIVHPWINKALERAQKKVEARNFDIRKNLLKYDDVLNDQRKVIFEQRLELMESTNISETVSDMRREVIEDLVEKHIPERAYAEQWDAVGLKTGVTNILNLDLPIEDWFKEEGIGEDDIRERLTEAANAAFTEKAERFGDDIMHYVERSIVMQTLDHLWREHIVNLDHLRSVIGFRGYAQRDPLQEYKSEAFELFTGLLNNLREAVTAQLMRVELVQQAPAEPEPPLMQAHHLDPMTGEDDFAPIYQASEVIVAPENRNPEDPTTWGKIGRNEACPCGSGKKYKHCHGAFEQV
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
B3PP95
Q96JJ7
TMX3_HUMAN
Thioredoxin-related transmembrane protein 3
Homo
MAAWKSWTALRLCATVVVLDMVVCKGFVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMKSIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRPLPSQQMFEHMQKRHRVFFVYVGGESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAVLVFKDETYFVYDEYEDGDLSSWINRERFQNYLAMDGFLLYELGDTGKLVALAVIDEKNTSVEHTRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQQYFLLDRQIKNVEDMVQFINNILDGTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSSPLMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSENENQEQIEESKEQQEPSSGGSVVPTVQEPKDVLEKKKD
Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase.
Q96JJ7
Q8YT40
KAIC_NOSS1
Circadian clock protein kinase KaiC
Nostoc
MSEKEQQEQQNTSGNGVEKIRTMIEGFDDISHGGLPVGRTTLVSGTSGTGKTLLSLQFLFNGISFFDEPGVFVTFEESPSDIIKNAHIFGWNLQRLINEGKLFILDASPDPEGQDIVGNFDLSALIERLQYAIRKYKAKRVSIDSITAVFQQYEAVGVVRREIFRLVARLKQLNVTTIITTERSEEYGPVASFGVEEFVSDNVVIARNVLEGERRRRTIEILKLRGTTHMKGEYPFTITNDGVNIFPLGAMRLTQRSSNVRVSSGVKTLDGMCGGGFFKDSIILATGATGTGKTLLVSKFLQNGCVNNERAILFAYEESRAQLSRNAYSWGIDFEELESQGLLKIICTYPESTGLEDHLQIIKSEIAYFKPARIAIDSLSALARGVSNNAFRQFVIGVTGYAKQEEITGFFTNTTDQFMGSHSITDSHISTITDTILMLQYVEIRGEMSRAINVFKMRGSWHDKGIREYNITADGPEIQDSFRNYERIVSGSPTRVSIDEKAELSRIVRRFEDKQGSDS
Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction.
Q8YT40
Q57G36
LPLA_SALCH
Lipoate--protein ligase
Salmonella
MTTLRLLISDSYDPWFNLAVEECIFRQMPATQRVLFLWRNADTVVIGRAQNPWKECNTRRMEEDNVRLARRSSGGGAVFHDLGNTCFTFMAGKPEYDKTISTHIVLAALNSLGVMADASGRNDLVVKTPDGDRKVSGSAYRETKDRGFHHGTLLLNADLSRLANYLNPDKKKLAAKGITSVRSRVANLTELLPGITHEQVCQAVTEAFFAHYGERVDAEVISPDKTPDLPNFAETFARQSSWEWNFGQAPAFSHLLDEHFTWGGVELHFDVEKGVITRAQVFTDSLNPAPLEALAGRLQGCQYRADVLEQACKSLIAEFPAQKGELRELAAWMAQAVR
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Q57G36
Q5KXT0
DER_GEOKA
GTP-binding protein EngA
Geobacillus thermoleovorans group
MANPVVAIVGRPNVGKSTIFNRIVGERISIVEDVPGVTRDRIYSRAEWLNHSFYLIDTGGIDIGDEPLLVQIRQQAEIAIDEADVIIFMTNGRDGVTAADEEVAKLLRRSNKPVVLAVNKIDNPEMRDLIYDFYALGFGEPYPISGAHGTGLGDLLDAVVRHFPKGGGQEYEEDVIKFCLIGRPNVGKSSLVNAILGEERVIVSDIAGTTRDAVDTSFVREGQEYVIIDTAGMRKRGKIYESTEKYSVLRALRAIERSDVVLVVLNAEEGIIEQDKKIAGYAHEAGRGVILIVNKWDAIEKDDKTMVEFERKIRDHFPFLDYAPILFVSAKTKQRLHKLLPLVRLVSDNHAMRVQTNVLNEVIMDAVAMNPTPTHNGRRLKVYYMTQVAVKPPTFVAFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIIARPRK
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Q5KXT0
P60165
KA112_PARVI
Parabutoxin-2
Parabuthus
DEEPKETCSDEMCVIYCKGEEYSTGVCDGPQKCKCSD
Binds and inhibits voltage-sensitive potassium channels. Inhibits the vertebrate potassium channel Kv1.1/KCNA1 with low affinity.
P60165
Q6CUB5
PFA4_KLULA
Protein fatty acyltransferase 4
Kluyveromyces
MAIKLKNRWLGVAIPAFLVALIGYGSHYFILSNFLSWNEQIFYQTCQTMIWVSYYLAIYTNPGIPPKDFKPSAEEWHNYCKKCRVYKPERAHHCKTCNQCVLAMDHHCPWTLNCVGHSNFPHFMRFLFWVIFSTAYLLFLLIGRIYLLWSIRHTAFHHRSTSEIIFICIMTPMDAFVLLTVSSLLGRCIYNQCLHGMTQIESWEMDRIQSLHYKNRLLAQVIDRLVERRPEILPAKQHEINKLLSKRYVNQEDFTNFPYDVNPWTNINNAMGPWYLWLWPWSKPPTIGTSFAKNELFFYDPNSSIEDMLMSLPWPPDGLTHHSRALGSGSSIETIVSGGEQVIRDKSVDLRDRLGRNSWYNDWGEDLSDFGVDTELE
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.
Q6CUB5
B6JKG8
HEM3_HELP2
Pre-uroporphyrinogen synthase
Helicobacter
MGNLVIGSRGSELALWQANHIKERLKKECLIESEIQIVKTKGDKILDTPLNKIGGKGLFTKELEELLLKGTIDLAVHSLKDVPVVFEKGLDLACITKRADVRDTFLSVKFPDLMSLPKGAKVGTTSLRRSMQLKLKRQDLDTESLRGNVQTRLKKLECGEFDAIILAEAGLCRLEIQGAKYRKAFSVKEMIPSMGQGALGVEMLKNHKHFATLQKLNDEKSAFCCRLEREFIKGLNGGCQIPIGVHASLMGDRVKIQAVLGLPNGKEVITKEKRGDKTKAFDLVQELLEEFLQSGAKEILEKAQLF
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
B6JKG8
A8AV19
METE_STRGC
Methionine synthase, vitamin-B12 independent isozyme
Streptococcus
MSTTIIGFPRLGEFRELKFTTEKYFRKEISADELLAAAKELRAKHWNIVKEKGISEIPSNDFSHYDNVLDAAFLFNVVPSSVRGLELTDLERYFALARGYQGEKGDVRALPMKKWFNTNYHYIVPKFEKETQVKLAGHKIFEEFAEAKELGLVTRPVVVGPFTLLQVSDFEDGVAPADFVDALATAYQEVFAKLAELGAKRIQLDEPSLVKDLSAEEKALFLDLYKKLLADKKGLEVLIQTYFGDVRDIYSDLVQLPVDAIGLDFVEGKKTLELVKGGFPADKTLYAGIVNGKNIWRNNYEKSLAVLEQIPAENIVLTSSCSLLHVPFTTANEEFEPAILNHFAFAVEKLDEIRDLDAIRNGQGAEALAANKELFATERVGENAELRARIAGLTDADYTRLPAFAEREAIQEEAFKLPALPTTTIGSFPQTKEVRAKRLAFRKGELSAEDYDKFLAEQIDEWIKWQEEVGFDVLVHGEFERNDMVEYFGQNLSGYLFSKNGWVQSYGMRGVKPPIIWGDVTRLNPITVKWSSYAQSRTEKPVKGMLTGPVTILNWSFPREDISIKDSTLQIALAIKDEVLDLEAAGVKIIQIDEAALREKLPLRRSDWYEDYLDWAIPAFRLVHSTVAPDTQIHTHMCYSEFTDIIPAIDNMDADVISFEASRSNLEILDELKAKNFQTEVGPGVYDIHSPRVPNEGEIDHTIEAILAKVPSKKVWINPDCGLKTRGIPETKASLVRLVEAAKAARQHLK
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
A8AV19
Q2N7E3
FOLD_ERYLH
Methenyltetrahydrofolate cyclohydrolase
Erythrobacter
MTAEIIDGKAFAARLRERVGALAEKFEAAAGRKPGLAVVLVGEDPASEVYVRNKGKATLAANMESFEYKLPADTTAQDLLALVKKLNGDPAVDGILVQLPLPDHLDEQSIIAAISPDKDVDGFHVINAGRLSVGQRGFVPCTPLGCMMLLADRLGDLSGLEAVVIGRSNIVGKPMAQLLLDANATVTIAHSRTRNLPEVVKRADIVVAAVGRAEMVKPEWLKDGATVIDVGINRLPPEPGKERGRLVGDVDFGRASEVAAAITPVPGGVGPMTIAVLLRNTLVAAHRNEGIDLPEDAI
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q2N7E3
Q48NZ0
RL9_PSE14
50S ribosomal protein L9
Pseudomonas
MQLILLEKVANLGNLGDKVNVKAGYGRNYLLPYGKATAATAANVAAFEERRAELEKLAADKKASAETRAAQLAELEVTITATAGDEGKLFGSIGTHDIADALTASGVEVAKSEVRLPNGTIRNVGEYDVAVHLHSDVEATVRVVVVAA
Binds to the 23S rRNA.
Q48NZ0
B1AIM0
RL3_UREP2
50S ribosomal protein L3
Ureaplasma
MKSLLGTKVGMTQVFTETGKAVAATVIYVEPNKVLAVKTNEKDGYSAIQIGYETVKEKALNKPLLGQFKKANSDPKRHIKEFRDVVAEVGAELTVSEFEPGQLVNAQAYTKGHGFTGSIKRHNFSMGPMGHGAGYPHRYVGSIAKGRGGSQAQRVFKGTKLPGHYGHELVTTKNLLVLDVKANENLILIKGAIPGPKGSIVLLKSAKKVGHIVSDPQVVNYLANKASSSEANE
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
B1AIM0
Q9AFA5
CH60_TSUPA
Heat shock protein 60
Tsukamurella
MAKTIAFDEEARRGLERGLNALADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEDPYEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNMAAGANPLGLKRGIEKAVEAVTEHLLKEAKEVETKEQIAATAGISAGDPAIGELIAEAMDKVGKEGVITVEESNTFGLQLELTEGMRFDKGFISGYFATDAERQEAVLEDAYILLVSSKISTVKDLLPLLEKVIQSGKPLAIIAEDVEGEALSTLIVNKIRGTFKSVAIKAPGFGDRRKAMLQDMAILTGGQVISEEVGLSLETAGLELLGQARQVVVTKDETTIVDGAGSKEQIEGRVSQIRAEIESSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGAALAQSGKVFETLNLEGDEATGANIVKVALDAPVKQIAINAGLEPGVVAEKVRNSPAGTGLNAATGVYEDLLAAGINDPVKVTRSALQNASSIAALFLTTEAVVADKPEKAGAPVDPTGGMGGMDF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Q9AFA5
Q4WNE1
CFMC_ASPFU
GPI anchored CFEM domain protein C
Aspergillus subgen. Fumigati
MKFFSVSLALAACLSMAAAQGLDGLPDCAKSCATNSIPASCGLDVKCICTDSSFISGISCCVLQSCGPDQQQEDAHPFFPTAAVEFANRICKTAGVTNMPQSPSCANTTQSATGTASKSSTATSGSSTESNASQTAATATTSTTPPTSPTSPTSTTGSTTSSAASTTNTTTGAAVTQHKDIGLIALAGAALAAFGLLA
GPI-anchored cell wall protein involved in stabilizing the cell wall. Not implicated in virulence, heme uptake, and biofilm formation.
Q4WNE1
P59584
RP8HA_ARATH
RPP8 homolog A
Arabidopsis
MAEGFVSFGLEKLWDLLSRESERLQGIDEQLDGLKRQLRSLQSLLKDADAKKHGSDRVRNFLEDVKDLVFDAEDIIESYVLNKLRGEGKGVKKHVRRLARFLTDRHKVASDIEGITKRISEVIGEMQSFGIQQIIDGGRSLSLQERQRVQREIRQTYPDSSESDLVGVEQSVTELVCHLVENDVHQVVSIAGMGGIGKTTLARQVFHHDLVRRHFDGFAWVCVSQQFTQKHVWQRILQELQPHDGEILQMDEYTIQGKLFQLLETGRYLVVLDDVWKKEDWDRIKAVFPRKRGWKMLLTSRNEGVGIHADPTCLTFRASILNPEESWKLCERIVFPRRDETEVRLDEEMEAMGKEMVTHCGGLPLAVKALGGLLANKHTVPEWKRVSDNIGSQIVGGSCLDDNSLNSVYRILSLSYEDLPTHLKHCFLHLAHYPEDSKIYTQDLFNYWAAEGIYDGSTIQDSGEYYLEELVRRNLVIADNRYLISEFKIKNCQMHDMMREVCLSKAKEENFLQIIKDPTCTSTINAQSPSRSRRLSIHSGKAFHILGHKRNAKVRSLIVSRFEEDFWIRSASVFHNLTLLRVLDLSWVKFEGGKLPCSIGGLIHLRYLRLYGAVVSHLPSTMRNLKLLLYLNLSVHNEDLIHVPNVLKEMIELRYLSIPVKMDDKTKLELGDLVNLEYLYGFSTQHTSVTDLLRMTKLRNLTVSLSERYNFKTLSSSLRELRNLETLYVLFSRKTYMVDHMGEFVLDHFIHLKELGLVVRMSKIPDQHQFPPHLVHIFLFYCGMEEDPMPILEKLHHLKSVQLRYKAFVGRRMVCSKDGFTQLCALDISKQSELEDWIVEEGSMPCLRTLTIHDCEKLKELPDGLKYITSLKELKIEGMKREWKEKLVPGGEDYYKVQHIPDVQFINCDQ
Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. In contrast to RPP8, it does not specifically recognize the Emco5 avirulence protein from Hyaloperonospora parasitica.
P59584
A1SYN3
Y2894_PSYIN
Nucleotide-binding protein Ping_2894
Psychromonas
MKLIVISGRSGSGKTIALHVLEDLGYNCIDGVPFQLLAQLIDTVDPKNNKVAISLDIRNLPTDASQIQTLLSSLQQKVEVEIIYLDAISAELIRRYSETRRLHPLSKNKLSLSQALELENELLEPIHKRAALSIDTTTLSIHNLNERLKIHLQGSTKSNLLIIFQSFGFKNIHPDDADYIFDVRFLPNPHWEPTLQKYTGKDQPVKAFLNGHLVVKQTINQIENLFHSWLPYLEENNRNYVTIAIGCTGGKHRSVYVAEQLAAQFKQKYQVQIEHKGLKDQL
Displays ATPase and GTPase activities.
A1SYN3
Q9XT00
DHB8_PIG
Testosterone 17-beta-dehydrogenase 8
Sus
MASQLRLRSALALVTGAGSGIGRAVSVRLAAEGAAVAACDLDGAAAQETVQLLGGPGSEKGAPSGPMAAFQADVSEAETARRLLEQVQAYFFRPPSVVVSCAGITRDEFLLRMSEDDWDKVIAVNLKGIFLVTQAAAQALVSSGCPGSIINISSIIGKVGNMGQTNYAASKAGVIGLTQAVARELGRYRIRCNSVLPGFIKTPMAQKVPQKVLDKVVGMIPMGHLGGPPDVADVVAFLASEDSGYITGASVEVTGGLFM
Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex, acts as scaffold protein, required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference, this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+)(H). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol.
Q9XT00
Q3ILK1
PANB_PSET1
Ketopantoate hydroxymethyltransferase
Pseudoalteromonas
MSKITVSTLNKMKAEKNKITALTAYDASFAKLFHDNGVEVILVGDSLGMVLQGGDDTLGVTNQDIAYHTRCVRAGSRELFVIADMPFMTYSSPNDTCKNAAELMRAGANMVKLEGGEWLFESIEALTQQGIPVCGHLGLTPQSVHVFGGFKVQGRAEEQALKIIADAKALEAAGAQLLVLECIPSALAKRVTDALTIPTIGIGAGNTTDGQILVMHDLVGISAGFIPKFSKNFLLETGNMPEAVKKYCTDVKSGAFPSAEHEFK
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Q3ILK1
C1DKL6
RL2_AZOVD
50S ribosomal protein L2
Azotobacter
MAIVKCKPTSAGRRFVVKVVNQELHKGAPYAPLLEKKSKSGGRNNNGRITTRHIGGGHKQHYRLVDFRRNKDGIPATVERIEYDPNRTAHIALLKYADGERRYIIAPKGVVAGDQLISGVNAPIKAGNTLPLRNIPVGSTIHGVELKPGKGAQIARSAGASAQLVAREGAYVTLRLRSGEMRKVLADCRATLGEVSNSEHSLRSLGKAGAKRWRGVRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGFPTKGAKTRSNKRTDNMIVRRRK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
C1DKL6
A3QFJ5
DNLJ_SHELP
Polydeoxyribonucleotide synthase [NAD(+)]
Shewanella
MQAIQDEIKQLTDELNQHNYRYYVDDAPSIPDAEYDRLMRRLQELEAEHPELALADSPTQRVGGEALSKFNQVTHLKPMLSLDNVFSEEEFNAFYKRVGDKLPDTPAFCCEPKLDGLAVSILYRDGVFERAATRGDGTVGEDITENVRTIKSVPLRLRGSGFPPLLEVRGEVFMPKAAFEAVNDKARAKGEKLFVNPRNAAAGSLRQLDSKITASRSLAFYAYALGVVEPETWPLAASHFEQLVQLKEWGCPVSSEVKVCADIPSVLAYYQDILTRRSELAYEIDGVVLKVNDIAQQQTLGFVAKAPRWATAYKFPAQEEITQLEGVDFQVGRTGAVTPVARLQPVFVGGVTVSNATLHNADEIARLGVMIGDSVIIRRAGDVIPQVVAVVPEKRPSDAQAIQFPPQCPVCGSDVERVEGEAVARCTGGLVCEAQRKEAIKHFASRKALDIDGMGDKVVEQLIDKELVASPADLFKLTASAITMLDRMGMKSATNLVNALEAAKQTTFARFLYSLGIREVGEATAANLANYFKTLEHLKQADAETFMKVDDVGVIVAQHLVHFFEQPHNLEVIDGLLQAGVHWPDIEEVAEEALSLKGQTWVLTGTLTQLNRNDAKAKLQALGAKVAGSVSKNTDCLVAGEAAGSKLTKAQELGVKVIDEAELLAILGS
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
A3QFJ5
C3PPA4
RL2_RICAE
50S ribosomal protein L2
spotted fever group
MALKNFNPITPSLRELVQVDKTSLWKGRPLKSLTKGISKTGGRNNQGRITSWHRGGGHKKLYRIIDFKRNKIDISAIVERIEYDPNRTAFIALIKYEDGEYSYILAPQKLSVGDRVISSQDADIKIGNCLPLKCIPIGTTLHNVEMKVGKGGQIARSAGTSVDLVGKDSGYAQIKLRSGEFRLVPLDCKATIGSISNPDQKNINLGKAGRNRWLGWRPHVRGVAMNPVDHPHGGGEGKTSGGRHPVTPWGFPTKGKKTRKNKRTSKFIVKKRK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
C3PPA4
P22626
ROA2_HUMAN
Heterogeneous nuclear ribonucleoproteins A2/B1
Homo
MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY
(Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport.
P22626
Q969P5
FBX32_HUMAN
Muscle atrophy F-box protein
Homo
MPFLGQDWRSPGQNWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRKEQYGDTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Q969P5
B3PN01
HRCA_META1
Heat-inducible transcription repressor HrcA
Metamycoplasma
MEKRTNYPQLTEKQNHFFKLIVDTYIKTGASVASKELVKRCNLKCSSATIRNVMASLEQIGFLEKYHISSGRVPSTLGLEYYAKFLVYNPKKYFDQKLEDLLAKRRIKIDATLEEAAAIVSEVAGVTVVATSNNAAETMKSIQLTTLSELSAIVVIVTSSGRVESKIFNFENSDISLEDLRVAIRLFKERLVDTPLIHLANKARALTPIFGQQLKNYELILQKFIKNIFVFEEETTNKTFNKGAIVLSRNISREEIANVLDLIEKHSVWESIDNDLDEDNNIKLDVSRPNLSIISKKIDFSNEKNIKEITVIGPNNLDYGESFEALEMLEKIIKEKK
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
B3PN01
O47667
COX2_CANAD
Cytochrome c oxidase polypeptide II
Canis
MAYPFQLGLQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETVWTILPAIILILIALPSLRILYMMDEINNPSLTVKTMGHQWYWSYEYTDYEDLNFDSYMIPTQELKPGELRLLEVDNRVVLPMEMTIRMLVSSEDVLHSWAVPSLGLKTDAIPGRLNQTTLMAMRPGLYYGQCSEICGSNHSFMPIVLEMVPLSYFETWSALMV
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
O47667
A8L6G0
RS15_FRASN
30S ribosomal protein S15
unclassified Frankia
MPLSGDVKQKIMSDYATVDRDTGSPEVQVAMLTRRISDLTEHLKVHKHDHHSRRGLLLLVGRRRRLLNYLAKTDINRYRALIERLGLRR
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
A8L6G0
B4THH4
METK_SALHS
Methionine adenosyltransferase
Salmonella
MAKHLFTSESVSEGHPDKIADQISDAVLDAILQQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHAEDIDQKSLQEAVMEEIIKPILPSEWLNTSTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPVEQLILLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGRENFPWEKTDKAQLLRDAAGLK
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
B4THH4
Q5PF36
NORW_SALPA
Flavorubredoxin reductase
Salmonella
MSRGIIIIGSGFAARQLVKNIRKQDAHVPLTLIAADSMDEYNKPDLSHVISQSQRADDLTRQLAGEFAEQFNLRLFPHTWVTDIDADAHVVKSQDKQWQYDKLVLATGAAAFVPPIAGRELMLTLNNQQEYRACETPLRDAQRVLIVGGGLIGSELAMDFCRAGKTVTLMDNAASLLASLMPPEVSSRLQHHLTDMGVHLLLKSQLQKLEKIEAGIRATLASQRSIEVDAVIAATGLRPETALARRAGVVVNRGVCVDSYLQTSHPDIYAIGDCAEINGQVLPFLQPIQLSAMYLAKNLLGGNAPLKLPAMLVKVKTPELPLHLAGETQRRDLSWQITAESDGMIAKGMSGEGQLRAFVVSEDRMKEAFALLKTLSV
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
Q5PF36
B2GM13
ENO_KOCRD
2-phosphoglycerate dehydratase
Kocuria
MAMIIALQARQILDSRGNPTVEVEALLDDGSFGRAAVPSGASTGEFEAVERRDGDKKVYQGKGVLDAVHAVDEELEQVVVGLDASDQRAVDQAMLELDGTDNKAKLGANAILGASMAIARAAASSADLPLYKYLGGPNAHVLPVPMMNILNGGSHADSNVDIQEFMIAPIGAPTFSEALRWGVEVYHSLKSVLKDRGLSTGLGDEGGFAPNLESNAAALDLILEAIDKAGYKPGRDIALALDVASSEFFDKGTYTFEGKKRSAEEMSAYFADLVEKYPLVSIEDPLDEDDWKGWATLTEHIGDKVQLVGDDLFVTNPERLARGIQEGVANALLVKVNQIGSLTETFDAVELAQRNGYRCMISHRSGETEDTTIADIAVAVNAGQIKTGAPARSERVAKYNQLLRIEEELGDAATYAGASAFPRFAAK
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
B2GM13
P23789
XRE_BACSU
Putative PBSX repressor
Bacillus
MIGGRLKSLRGKRTQEEIASHIGVSRARYSHYENGRSEPDYDTLQKLADYFQVTTDYLLTGKDKKSDDDMFSDPDLQLAYRDMQDFSPESKQQAIEFINYLKEKEKNRKPKNK
Repressor of PBSX. Binds to four sites close to its own gene. Necessary for the maintenance of the lysogenic state.
P23789
Q6YQC1
END4_ONYPE
Endonuclease IV
Candidatus Phytoplasma asteris
MLFLGSHVAMKKPHNFQGAIQTAISYGANALMVYSGAPQNTIRTKTEELKIKQALEIVQNNNLSLNNLVGHAPYIINLANPDETKRAFAIDFLSQELERFAAMKINKMVLHPGNYLKTNPQEGISLIAQSLDLIFEKTKHLKTQVALETMAGKGTEIGKNLEELQQIRTQVKNNTRVSFCLDTCHLFDAGYDLKENLEEIIQKIDSILGFQNISVIHINDSKNECNSHKDRHENIGFGKIGFETLLKIIYHRAFACIPKILETPYINDKAPYKREIEMIKAKAFNPELKKLF
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Q6YQC1
Q86TU7
SETD3_HUMAN
SET domain-containing protein 3
Homo
MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKSVLKNHDLSVRAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQMEEKAPLPKYEESNLGLLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKATENGLVNGENSIPNGTRSENESLNQESKRAVEDAKGSSSDSTAGVKE
Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' . Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery . Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin .
Q86TU7
Q6GGB8
HRCA_STAAR
Heat-inducible transcription repressor HrcA
Staphylococcus
MITDRQLSILNAIVEDYVDFGQPVGSKTLIERHNLNVSPATIRNEMKQLEDLNYIEKTHSSSGRSPSQLGFRYYVNRLLEQTSHQKTNKLRRLNQLLVENQYDVSSALTYFADELSNISQYTTLVVHPNHKQDIINNVHLIRANPNLVIMVIVFSSGHVEHVHLASDIPFSNDKLNTISNFVTNKLTEFNQNLQDDIVSFVQSEQEEIFINKLLNTMNNHISNQSNSIYMGGKVKLIDALNESNVSSIQPILQYIESNRIAELLQDISSPNINVKIGNEIDDSLSDISIVTSQYHFDETLKGQIAVIGPTAMHYQNVIQLLNRIW
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
Q6GGB8
Q9FFP1
ARI14_ARATH
RING-type E3 ubiquitin transferase ARI14
Arabidopsis
MEYDGRRPYSVLTRNEITVKMKKQINEISDIFFISNSDATVLLMYLRWDSLRVSERLGENKEKLLMDSGLKSVMIDPSPDSSSEISLETDVYEFDGDNDLISMPFCSHKFDSKYWREYLEKNFYYVEKIQTTISCPDQDCRSAVGPDTIEKLTVRDQEMYERYIWRSYIEGNKVLMIKQCPARNCDYVIEFHQENDDDDEYSLNVVCICGHIFCWRCRLESHRPVSCNKASDWLCSATMKISDESFSLYPTKTKTVTCPHCLCSLESDTKMPQFLTCVCRLRFCSRCLRSEEAHKIEAVDSGFCIKTEVGILCEDRWNVCQKLLEQAKSDLEAFEETNIKKPSDLLREQDIMIIREGLMLIVQCRRVLKWCCVYDYFHTEYENSKEYLRYLQGNAIATLQSYSNTLQEQKDIVLAAATYEECTFFRHTIPTATSNIGNYFYDFMKTLQDGLVDVKVKSYNGGTGPFWYCDRCTYANTWEDNECEMCYDDSASLVGEISDLFLNKVS
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates . Regulates negatively male gametophyte formation and double fertilization .
Q9FFP1
B5F5L4
METK_SALA4
Methionine adenosyltransferase
Salmonella
MAKHLFTSESVSEGHPDKIADQISDAVLDAILQQDPKARVACETYVKTGMVLVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSPDINQGVDRADPLEQGAGDQGLMFGYATNETDVLMPAPVTYAHRLVQRQAEVRKNGTLPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHAEDIDQKSLQEAVMEEIIKPILPSEWLNTSTKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMARHGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAEPTSIMVETFGTEKVPAEQLILLVREFFDLRPYGLIQMLDLLHPIYKETAAYGHFGRENFPWEKTDKAQLLRDAAGLK
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
B5F5L4
Q1QS30
IHFB_NITHX
Integration host factor subunit beta
Nitrobacter
MIKSELVQRIAEHNPHLYQRDVENIVNAILDEIVTALARGDRVELRGFGAFSVKHRPARAGRNPRTGEHVPVDQKSVPFFKTGKEMRERLNRENATSEASA
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
Q1QS30
Q5E2K3
PLSY_ALIF1
Lysophosphatidic acid synthase
Aliivibrio
MTPLALIMIIIAYLLGSISSAVLICRLKGLPDPRTSGSHNPGATNVFRIGGRSAAGLVLLCDILKGMLPVWGGYFLEINPFMLGIIAISACLGHMYPLFFHFKGGKGVATALGALAPIGLDLTGMLFGCWVVTVLVTGYSSLASMITALLAPLFTWLVKPQYTLPVAMLSCLIVLKHHENIKRFFEGKETKIWQRKRD
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Q5E2K3
A8MVX0
ARG33_HUMAN
Rho guanine nucleotide exchange factor 33
Homo
MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDSNVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASPTAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMESMQPGKPSDWELEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPEMDFESSPAEPLGNVERSLRAPAELLPDARGFVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAPPADGVAPRLYSTRSSSGGRAPIKAERAAQAHGPAAAAVAARGASRTFFPQQRSQSEKQTYLEVRREMHLEDTTRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNATGEDFCGPWGWW
May act as a guanine-nucleotide releasing factor.
A8MVX0
Q6G252
IF1_BARHE
Translation initiation factor IF-1
Bartonella
MSKEEVLEFSGIVTELLPNAMFRVKLENDHEIIAHTAGRMRKNRIRVLAGDKIMVEMTPYDLTKGRIIYRYK
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Q6G252
B2AWV6
AMPP1_PODAN
Prolidase
Podospora anserina
MRHIWALPSLTALSLFQASAASAVPRARQAINTSSPLAPFRTKRRFRTQAQLLSNSATKTTLVEEMVTVDTTSRLAALRSLMKERNLHVYVVPSEDSHASEYIADCDARRTFISGFSGSAGTAIVTLDKAALATDGRYFNQASKQLDSNWYLLKTGMQDVPTWQEWATQEAEGGKLIGVDPQLISSAIAEKLDEDIKNAGGGGLVGIKENLVDLVWGSEQPPRPSNSVFLLGQQYAGKDTAAKLADLRKELDKKKAAGFVLSMLDEIAWLFNLRGSDIAYNPVFFSYAIVTQASATLYIDEAKLTDECKTYLERNKVTIKPYGALFEDSEELARRAEADSKDAKPRKYLISSKGSWALKLALGGNKFVDEVRSPVGDAKAVKNDVELNGMRNCHIRDGAALTEFFAWLEDQLVNQKAQLDEVDAADKLEQIRSKHKDFVGLSFDTISSTGANAAVIHYKPEKGACKIIDPNAIYLCDSGAQYLDGTTDTTRTLHFGTPTAKEKKAYTLVLKGNIALDSVVFPKGTSGFAIDVMARQFLWKYGLDYRHGTGHGVGSFLNVHEGPIGIGTRKQYIDVALAAGNVLSIEPGYYEDEAFGIRIENLAIVKEVKTEHSFGDKPYLGFEHVTMVPYARNLIDETLLTPDEKDWLNRANKKILEKTLGYFENDPLTKAWLLRETQPF
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
B2AWV6
A5F6X0
CLPP_VIBC3
Endopeptidase Clp
Vibrio
MSPIFDALVPMVVEQTSRGERSYDIYSRLLKERVIFLTGQVEDHMANLVVAQLLFLESENPDKDIFLYINSPGGSVTAGMSIYDTMQFIKPNVSTVCMGQACSMGAFLLAGGAPGKRYVLPNSRVMIHQPLGGFQGQASDIQIHAQEILTIKNKLNRLLAEHTGQPIEVIERDTDRDNFMSADQAVEYGLVDAVLKHRGE
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
A5F6X0
A4J3G3
NADK_DESRM
ATP-dependent NAD kinase
Desulforamulus
MNTIGLVVNSSKGDVAKPVREVISWLAEQRIKVLYNEESAVLLGCPEEGISTRELGAQCDCIMVWGGDGTLLNCARQTASSGTPIFGVNLGRLGFLTEIDIPDLRERLQALIAGHFYIEERMMLEATVIRGGQVVDQAVCLNDAVVSKGASFRMVQLRILVNNEFVGSFAADGVIVASPTGSTAYSLAAGGPIISPDMEAMLITPICPHSLSNRPIVISPQSKVEVQVLPYVDKVGLNLDGQYGLPLREGDRILINRATVKARFLKIQKTGFYDVLREKLKEWQNGLD
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
A4J3G3
Q90922
NET1_CHICK
Netrin-1
Gallus
MPRRGAEGPLALLLAAAWLAQPLRGGYPGLNMFAVQTAQPDPCYDEHGLPRRCIPDFVNSAFGKEVKVSSTCGKPPSRYCVVTEKGEEQVRSCHLCNASDPKRAHPPSFLTDLNNPHNLTCWQSDSYVQYPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGKTWVPFQFYSTQCRKMYNKPSRAAITKQNEQEAICTDSHTDVRPLSGGLIAFSTLDGRPTAHDFDNSPVLQDWVTATDIKVTFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHASRCVRDRDDNLVCDCKHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGFYRDLSKPISHRKACKECDCHPVGAAGQTCNQTTGQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPAAPPPTAASSTEEPADCDSYCKASKGKLKINMKKYCKKDYAVQIHILKAEKNADWWKFTVNIISVYKQGSNRLRRGDQTLWVHAKDIACKCPKVKPMKKYLLLGSTEDSPDQSGIIADKSSLVIQWRDTWARRLRKFQQREKKGKCRKA
Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors.
Q90922
Q6PFX2
BEND6_MOUSE
BEN domain-containing protein 6
Mus
MQKILQTDDITDNQVLRKRKRKRTETANSENANSALEKAQRDPYSGNAFLPGESSSDEETPLMELSKEELCNKIESLKEKLRSIRKENSRLRQSLVMLQVLPQAVTQFEELVGMAETLLKSGGAVSTPASTLWRATNNSSPDSFASLCSNSNSTSSSPSSVKAEEEQHPGEKQFTIERWQIARCNKSKPQKFINDLMQVLYTNEYMATHSLTGAKSSTSRDKVVKPAMNQNEVQEIIGVTKQVFPSADDVSIRRMIGQKLNNCTKKPNASKAPNSQDGILK
Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis .
Q6PFX2
Q6TEN6
WDR91_DANRE
WD repeat-containing protein 91
Danio
MASAVERTDDLVREYLIYRGFTSTLKHLDSEIKTDKEKGFRVDKIMDQLQLLIQSCDLTGLKEYWANLERRLFCRLEDVYKPTVSKLRTSLYRFYLIHTVQVKNVEKTQEFFQKQALELQAQAEWRDWFSLPFIPAPEQNPSFSAYFSRQWADTFLVSLHNFLSVLFQCMPLPALLSFDSEVQRITSLQEDNEQLRQTVFALQGESRLKKDEQMVHHKLPPYVQHMDRLGDTELDLVSSQRNVNMATPSRNFFSTFLPQGRRAPGRTAPGPQSSPTQSALGRKDAAASMQSSKAKDKEVKPPSVSSMTAELSTSHPRQRRHQDHEKERKELFSKHAAQGSEKKTDSDPDTQTEAPPDQTDSANQTRVCDVGGAGAEQPFIKLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVVKVWAFNPIMQTKATIMSKSPLLSLEWAAKPDRLLLLGSGVGTVKLYDTDAKKCLYEMTIDDVHPRILSLACSPSGTSFVCSAAAHSGAVMESEPRGSAPVSGQLLLWDTKTVKQQLQFALEPGPVAINCTAFNHNGNLLVTGAADGIIRLFDMQRYESALSWKAHDGEVYSVEFSYDENTVFSIGEDGKFVQWNIHRCGVKQSEYSLSQDAVGPFVLSGYSGYKQVQVPRGRLFAFDSEGQHVLTCSSTGGNIYRLNKAEAGLESVLSLAGHKAPVVTVDWCSAMDCGTCLTASMDGKIKLSTLLAQKP
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport.
Q6TEN6
Q9WTM2
DDX6_CAVPO
Oncogene RCK homolog
Cavia
MGLSSQNGQLRGPVKPSGGPGGGGTQTQQQMNQLKNTNTINNGTQQQAQSMTTTIKPGDDWKKTLKLPPKDLRIKTSDVTSTKGNEFEDYCLKRELLMGIFEMGWEKPSPIQEESIPIALTGRDILARAKNGTGKSGAYLIPLLERLDLKKDNIQAMVIVPTRELALQVSQICIQVSKHMGGAKVMATTGGTNLRDDIMRLDDTVHVVIATPGRILDLIKKGVAKVDHVQMIVLDEADKLLSQDFVQIMEDIILTLPKNRQILLYSATFPLSVQKFMNSHLQKPYEINLMEELTLKGVTQYYAYVTERQKVHCLNTLFPRLQTNQSIIFCNSSQRVELLAKKISQLGYSCFYIHAKMRQEHRNRVFHDFRNGLCRNLVCTDLFTRGIDIQAVNVVINFDFPKLAETYLHRIGRSGRFGHLGLAINLITYDDRFNLKSIEEQLGTEIKPIPSNIDKSLYVAEYHSEPVEDEKP
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts.
Q9WTM2
P36160
RPF2_YEAST
Ribosome biogenesis protein RPF2
Saccharomyces
MIRTVKPKNARAKRALVKREAKLVENVKQALFIPGQSCNKNLHDIMVDLSALKKPDMKRFNRKNDIHPFEDMSPLEFFSEKNDCSLMVLMTSSKKRKNNMTFIRTFGYKIYDMIELMVADNFKLLSDFKKLTFTVGLKPMFTFQGAAFDTHPVYKQIKSLFLDFFRGESTDLQDVAGLQHVISMTIQGDFQDGEPLPNVLFRVYKLKSYKSDQGGKRLPRIELVEIGPRLDFKIGRIHTPSPDMVTEAHKKPKQLEMKTKKNVELDIMGDKLGRIHMGKQDLGKLQTRKMKGLKSKFDQGTEEGDGEVDEDYEDEASYSDDGQEYEEEFVSATDIEPSAKRQKK
Required for biogenesis of the 60S ribosomal subunit.
P36160
A4VR22
PSD_PSEU5
Phosphatidylserine decarboxylase beta chain
Pseudomonas
MKDRLFVISQYVLPHHLISRLAGCLAECRLPWVKNTFIKWFVRHFQVDMREAQIEEPTAYEHFNAFFTRALKDGARPLDSTPGAILNPCDGAISQLGKIEQGRIFQAKGHSFSAMELLGGDHERAAPFMGGAFATVYLSPKDYHRVHMPVSGTLREMVYVPGRIFSVNTVTAQGVPELFARNERVVCLFDTEHGPMAMVLVGAMIVASIETVWAGLVTPPKRSLKTFRYDEAARAPIHLEKGAEMGRFKLGSTVILLFGPDRVRWAEQLGPLSPVCMGESLGQAAITAAASEAIELQ
Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
A4VR22
Q7T2N4
RL15_SILME
60S ribosomal protein L15
Silurus
MGASKYMQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRLGYKAKQGYVIYRVRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSIAEERAGRHCGGLRVLNSYWVGEDSTYKFFEVILIDTFHKAIRRNPDMQWITKAVHKHREMRGLTSAGKKSRGLGKGHKFHLTIGGSRRAAWRRRNTLQLHRYR
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Q7T2N4
B8D6X3
CCA_BUCAT
tRNA-NT
Buchnera
MKIYLVGGAVRDSLLNLPVKDKDWVVVGGTEKILLERNFQQVGKDFPVFLHPETHEEYALARKERKSGKGYTGFDTDCNSDVTLEEDLIRRDLTINAIAQDEYGNYIDPFQGKKDIECGLIRHVSESFIEDPLRVLRVARFAATLVHLGFKIAEETMLLMCIIVKKQELSYLTSNRIWNETEKALKTLNPHVYFQVLYECNALHFFFPEMYFLYEKKNFLNRSFFKKFCNKNIILMGLAEISLLNKDIDVRFSYLCQFLSVNQIDRNYSKIFFDSYAASIIHSLCKRFKIPSYIRDIAVLNTGFYFFLNTIHYQSSKNIINLFSKVDAWRKPDRVKKLAFLSNFNFLRNFKSEFFCIKSGCFLEKCFSVVKNVSIKLILKKGFKGYEIKQEITRLRIKKLEFWRIKNIKHRFYL
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
B8D6X3
B0CRK4
EFTS_LACBS
Elongation factor Ts, mitochondrial
Laccaria
MYRNCRKAFTFSLRHYSTAPTEKPSLKLVAELRKRTEVSITKAREALSASNNDVSAALEWLQKDLITSGAKKAAKLGGRPTPEGLISVSVLSRGGESHVAGVRAAMIELNCETDFVGRNELFGRLAADIAHTAAYISDRTGSATAFNRAFPLDVLKDAPLLSQLNPTAPPTGTVGSSIRDMISKVGENVSLRRALAVVENSPSPNGDIALRIGSYVHDYKIGSLALLALKSRGISSSLNSDAFRERLEFLERALARQILGFETTSVNSSEDQTSLYNQPFMMFSREMDSPLVGEVLRNWSEKEGLLKENSDGGVAVLDFAKWKVGETFDE
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
B0CRK4
P29040
XPSN_XANCP
Protein XpsN
Xanthomonas
MRLEMIGLRTWLLATVVGWALLVCVLAVAGLGKRVELLPDDPALVQRLPALPAPAPERLGPFEKYAEIAAHPAFAEDRLPHPFFLSGNDGSGAASTVRLTGVLLTSTFKMATLTLDPADSVRVQLGGDAVKGYRLLALQPRSATIEGPGGTQTLELQVFNGQGGQPPTAIGGRPQAPGAVPPLPPNVPPAPATPAPPPAEVPQQQPGGQAPPTVPPQRSDGAQEAPRPSDEQMRAIRERIEARRRQLQQQRQGGSTPGQTQ
Involved in a general secretion pathway (GSP) for the export of proteins.
P29040
P61909
DUT_LEPIC
dUTP pyrophosphatase
Leptospira
MKIFVQKLRPNAELPLLQTKQAAGYDIHACLDSKLVLEPGNVGLVPTGLSFAIPQEFHFEIRPRSGFSTKNRILIPNSPGTIDSDYRGELMIPLLNLGDSSFIIEHGMRIAQLLIRKTWYADWELVSEFADRTERGANGFGSTGH
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
P61909
Q9UGU0
TCF20_HUMAN
Stromelysin-1 PDGF-responsive element-binding protein
Homo
MQSFREQSSYHGNQQSYPQEVHGSSRLEEFSPRQAQMFQNFGGTGGSSGSSGSGSGGGRRGAAAAAAAMASETSGHQGYQGFRKEAGDFYYMAGNKDPVTTGTPQPPQRRPSGPVQSYGPPQGSSFGNQYGSEGHVGQFQAQHSGLGGVSHYQQDYTGPFSPGSAQYQQQASSQQQQQQVQQLRQQLYQSHQPLPQATGQPASSSSHLQPMQRPSTLPSSAAGYQLRVGQFGQHYQSSASSSSSSSFPSPQRFSQSGQSYDGSYNVNAGSQYEGHNVGSNAQAYGTQSNYSYQPQSMKNFEQAKIPQGTQQGQQQQQPQQQQHPSQHVMQYTNAATKLPLQSQVGQYNQPEVPVRSPMQFHQNFSPISNPSPAASVVQSPSCSSTPSPLMQTGENLQCGQGSVPMGSRNRILQLMPQLSPTPSMMPSPNSHAAGFKGFGLEGVPEKRLTDPGLSSLSALSTQVANLPNTVQHMLLSDALTPQKKTSKRPSSSKKADSCTNSEGSSQPEEQLKSPMAESLDGGCSSSSEDQGERVRQLSGQSTSSDTTYKGGASEKAGSSPAQGAQNEPPRLNASPAAREEATSPGAKDMPLSSDGNPKVNEKTVGVIVSREAMTGRVEKPGGQDKGSQEDDPAATQRPPSNGGAKETSHASLPQPEPPGGGGSKGNKNGDNNSNHNGEGNGQSGHSAAGPGFTSRTEPSKSPGSLRYSYKDSFGSAVPRNVSGFPQYPTGQEKGDFTGHGERKGRNEKFPSLLQEVLQGYHHHPDRRYSRSTQEHQGMAGSLEGTTRPNVLVSQTNELASRGLLNKSIGSLLENPHWGPWERKSSSTAPEMKQINLTDYPIPRKFEIEPQSSAHEPGGSLSERRSVICDISPLRQIVRDPGAHSLGHMSADTRIGRNDRLNPTLSQSVILPGGLVSMETKLKSQSGQIKEEDFEQSKSQASFNNKKSGDHCHPPSIKHESYRGNASPGAATHDSLSDYGPQDSRPTPMRRVPGRVGGREGMRGRSPSQYHDFAEKLKMSPGRSRGPGGDPHHMNPHMTFSERANRSSLHTPFSPNSETLASAYHANTRAHAYGDPNAGLNSQLHYKRQMYQQQPEEYKDWSSGSAQGVIAAAQHRQEGPRKSPRQQQFLDRVRSPLKNDKDGMMYGPPVGTYHDPSAQEAGRCLMSSDGLPNKGMELKHGSQKLQESCWDLSRQTSPAKSSGPPGMSSQKRYGPPHETDGHGLAEATQSSKPGSVMLRLPGQEDHSSQNPLIMRRRVRSFISPIPSKRQSQDVKNSSTEDKGRLLHSSKEGADKAFNSYAHLSHSQDIKSIPKRDSSKDLPSPDSRNCPAVTLTSPAKTKILPPRKGRGLKLEAIVQKITSPNIRRSASSNSAEAGGDTVTLDDILSLKSGPPEGGSVAVQDADIEKRKGEVASDLVSPANQELHVEKPLPRSSEEWRGSVDDKVKTETHAETVTAGKEPPGAMTSTTSQKPGSNQGRPDGSLGGTAPLIFPDSKNVPPVGILAPEANPKAEEKENDTVTISPKQEGFPPKGYFPSGKKKGRPIGSVNKQKKQQQPPPPPPQPPQIPEGSADGEPKPKKQRQRRERRKPGAQPRKRKTKQAVPIVEPQEPEIKLKYATQPLDKTDAKNKSFYPYIHVVNKCELGAVCTIINAEEEEQTKLVRGRKGQRSLTPPPSSTESKALPASSFMLQGPVVTESSVMGHLVCCLCGKWASYRNMGDLFGPFYPQDYAATLPKNPPPKRATEMQSKVKVRHKSASNGSKTDTEEEEEQQQQQKEQRSLAAHPRFKRRHRSEDCGGGPRSLSRGLPCKKAATEGSSEKTVLDSKPSVPTTSEGGPELELQIPELPLDSNEFWVHEGCILWANGIYLVCGRLYGLQEALEIAREMKCSHCQEAGATLGCYNKGCSFRYHYPCAIDADCLLHEENFSVRCPKHKPPLPCPLPPLQNKTAKGSLSTEQSERG
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
Q9UGU0
P0C8F1
PATE4_HUMAN
PATE-like protein B
Homo
MRKMNTLLLVSLSFLYLKEVMGLKCNTCIYTEGWKCMAGRGTCIAKENELCSTTAYFRGDKHMYSTHMCKYKCREEESSKRGLLRVTLCCDRNFCNVF
May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.
P0C8F1
Q61079
SIM2_MOUSE
SIM transcription factor
Mus
MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGLGDAWGQPSRTGPLDSVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHPPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLHSNMFMFRASLDLKLIFLDSRVTELTGYEPQDLIEKTLYHHVHGCDTFHLRYAHHLLLVKGQVTTKYYRLLSKLGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTDVEYKELQLSLDQVSTSKSQESWRTTLSTSQETRKSAKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECSQVGNWRTSPPTNAVAPPEQQLHSEASDLLYGPPYSLPFSYHYGHFPLDSHVFSSKKPGLPAKFGQPQGSPCEVARFFLSTLPASSECQWHCANSLVPSSSSPAKNLSEPSPVNAARHGLVPNYEAPSAAARRFCEDPAPPSFPSCGHYREEPALGPAKAPRQASRDAARLALARAPPECCAPPAPEPQAPAQLPFVLLNYHRVLARRGPLGSAAPGAPEAAGSLRPRHPGPVAASAPGAPRPHYLGASVIITNGR
Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development.
Q61079
B1J2Z8
METK_PSEPW
Methionine adenosyltransferase
Pseudomonas
MSEYSLFTSESVSEGHPDKIADQISDAVLDAIITQDKYARVACETLVKTGVAIIAGEVTTSAWVDLEELVRKVIIDIGYNSSDVGFDGATCAVMNIIGKQSVDIAQGVDRSKPEDQGAGDQGLMFGYASNETDVLMPAPICFSHRLVERQAEARKSGLLPWLRPDAKSQVTCRYENGKVVGIDAVVLSTQHNPEVSQKDLQEAVMELIVKHTLPAELLHKDTQYHINPTGNFIIGGPVGDCGLTGRKIIVDSYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCEIQVSYAIGVAQPTSISINTFGTGKVSDDKIIQLVRECFDLRPYAITKMLDLLHPMYQETAAYGHFGRTPQQKTVGDDTFTTFTWERTDRAQSLRDAAGL
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
B1J2Z8
Q6MRI1
CH60_BDEBA
Chaperonin-60
Bdellovibrio
MSKVITFSEDARTHILKGVNTLANAVKVTLGPKGRNVVIDKSFGSPLITKDGVTVAKEIELENKFENMGAQMVKEVASKTNDEAGDGTTTATVLAQAIYREGAKLVSAGHNPMSIKRGIDKAVGIIIEELKSMSKPVKGSNEVAQVGAISANNDKEIGQMLADAMDKVGREGVITIEESKTAKTEVTVVEGMQFDRGYLSPYFVTNAERMEAVLENAYVLVYDKKISSMKDMIGILEGVAKQGRQLLIIAEDVEGEALATLVVNKLRGTLHIAAVKAPGFGDRRKAMLEDIAILTGAKVISEDVGLKLEAATVADLGVAKRIVVDKDNTTIIDGAGKKNDINGRVGQIKAQIEETSSDYDKEKLKERLAKLAGGVAVIHVGAPSEVEMKEKKHRVEDALNATRAAVEEGIVAGGGTALLRASTKIDKSKFSEEEQFGATIIKRACEEPIRQIAANAGLDGAIVLDRILQNKSTTWGFNAYSDEYTDLIKDGVIDPVKVVRCALTNAASVSSLMLTTETMIAEAPKKESAAPAMPGHDGMGGMGGMM
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Q6MRI1
Q9V0D9
APBC_PYRAB
Iron-sulfur cluster carrier protein
Pyrococcus
MTIKAPALNLPGLGADPLTQRIKEKEKKWKYKVAVLSGKGGVGKSTVAVNLTAALAKMGYFVGILDADIHGPNVAKMLGVEKEEIYAEKFDDGHFEMIPPMADFMGQVTPIKVMSMGMMVPEDQPIIWRGALVTKAIKQLLGDVKWGSLDFMIIDFPPGTGDEILTVVQSIQLDAAIIVTTPQEVALLDTGKAVNMMKKMEVPYIAVVENMSYLICPHCGNKIDIFGEGGGEKLAEKEGVDFLGKIPIDLKAREASDLGIPIVLYGDTPAAKAFMEIAEKLVNKLKEMKGDEKKE
Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.
Q9V0D9
C4K8I6
HLDD_HAMD5
ADP-L-glycero-beta-D-manno-heptose-6-epimerase
Candidatus Hamiltonella
MIIVTGGAGFIGSNIVRALNKIGYQDILVVDNLEKGAKFVNLVDLKIADYRDKDDFITSVRAKEVLGNIEAIFHLGACSSTMEWDGQFMMKNNYEYSKTLLHFCLKACIPFLYASSAAVYGGRTDCFIEEPQYEKPLNIYGYSKFLFDQYVRKIWPKARAPICGFRYFNVYGPRETHKGSMASVVFHLDKQIKAGKPPQLFLGSEQFKRDFIFVDDVAQINLWCWQNQISGIFNCGTGHAASFQTLADTVVAYHNSKPVQYVDFPENLKGCYQTFTQADITKLRTIGYDKPFKPLDEGVTHYLDWLNHQ
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
C4K8I6
Q61137
ASTN1_MOUSE
Neuronal migration protein GC14
Mus
MALAGLCALFACCWGPAAVLATAAGDVDPSKELECKLKSITVSALPFLRENDLSIMHSPSASEPKLLFSVRNDFPGEMVVVDDLENTELPYFVLEISGNTEDIPLVRWRQQWLENGTLLFHIHHQDGAPSLPGQDPTEEPQHESAEEELRILHISVMGGMIALLLSILCLVMILYTRRRWCKRRRVPQPQKSASAEAANEIHYIPSVLIGGHGRESLRNARVQGHNSSGTLSIRETPILDGYEYDITDLRHHLQRECMNGGEDFASQVTRTLDSLQGCNEKSGMDLTPGSDNAKLSLMNKYKDNIIATSPVDSNHQQATLLSHTSSSQRKRINNKARAGSAFLNPEGDSSTEAENDPQLTFYTDPSRSRRRSRVGSPRSPVNKTTLTLISVTSCVIGLVCSSHVSCPLVVKITLHVPEHLIADGSRFILLEGSQLDASDWLNPAQVVLFSQQNSSGPWAMDLCARRLLDPCEHQCDPETGRREHRAAGECLCYEGYMKDPVHKHLCIRNEWGTNQGPWPYTIFQRGFDLVLGEQPSDKIFRFTYTLGEGMWLPLSKSFVIPPAELAINPSAKCKTDMTVMEDAVEVREELMTSSSFDSLEVLLDSFGPVRDCSKDNGGCSKNFRCISDRKLDSTGCVCPSGLSPMKDSSGCYDRHIGVDCSDGFNGGCEQLCLQQMAPFPEDPTLYNILMFCGCIEDYKLGVDGRSCQLVTETCPEGGDCGESREVPMNQTLFGEMFFGYNNQSKEVATGQVLKGTFRQNNFARGLDQQLPDGLVVASVPLENQCLEEISEPTPDPDFLTGMVNFSEVSGYPVLQHWKVRSVMYHIKLNQAAISQAFSNALHSLDGATSRADFVALLDQFGNHYIQEAVYGFEESCSIWYPNKQVQRRLWLEYEDISKGNSPSDESEERERDPKVLTFPEYIASLSDSGTKRMAAGVRMECQSKGRCPSSCPLCHVTSSPETPAEPVLLEVTRASPIYELVTNNQTQRLLQEATMSSLWCSGTGDVIEDWCRCDSTAFGADGLPTCAPLPQPVLRLSTVHEPSSNLVVLEWEHSEPPIGVQIVDYLIRQEKVTDRMDHSKVETETVLSFVDDIISGAKAPCAMPSQVPDKQLTTISLIIRCLEPDTIYMFTLWGVDNTGRRSRPSDVIVKTPCPVVDDVKAQEIADKIYNLFNGYTSGKEQQTAYNTLLDLGSPTLHRVLYHYNQHYESFGEFTWRCEDELGPRKAGLILSQLGDLSSWCNGLLQEPKISLRRGSLKYLGCRYSEIKPYGLDWSELSRDLRKTCEEQTLSVPYNDYGDSKDI
Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.
Q61137
P54450
CWLH_BACSU
Cell wall hydrolase
Bacillus
MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHAKFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGDFEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTPPKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKTANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK
Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella and sporulation. Could play a role in mother cell lysis with CwlC.
P54450
Q9GPR0
FA96A_DICDI
MIP18 family protein FAM96A
Dictyostelium
MIMNYNVIDKIDVFDIIRHIKDPEFPKTLEELKVVNEDWITVIDNNDINDSDDINNNNNENYKGYCFIKILFQPTVPHCHLAPTIALCIREKIKEYLPKRSKIEIYIKKGTHQTEDEINKQINDKERIIAALENPEIFQLVKKCIKEDDY
May play a role in chromosome segregation through establishment of sister chromatid cohesion.
Q9GPR0
Q8PFZ6
UNG_XANAC
Uracil-DNA glycosylase
Xanthomonas
MTEGEGRIQLEPSWKARVGDWLLRPQMRELSAFLRQRKAAGARVFPPGPQIFAAFDATPFEQVKVVILGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNREREGLVFLLWGSYAQSKGKVIDQTRHRVLKAPHPSPLSAHRGFLGCQHFSKTNDHLRRRGLSPIDWSLPPRSALDLTSAGA
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Q8PFZ6
Q9LW26
PES2_ARATH
Phytyl ester synthase 2, chloroplastic
Arabidopsis
MAVTVLPSVSGLSAVASSSNLRRLTSASNHRLTAIKSVTSTSSPPTPSSGVQRRRKNNDENRATVAKVVENPYSKVEAARPDLQKRLSDFLEEAREFVGDGGGPPRWFSPLECGAQATNSPLLLYLPGIDGTGLGLIRHHKKLGEIFDIWCLHIPVSDRTPVKDLVKLIEETVKSENFRLPNRPIYLVGESIGACLALDVAARNPNIDLSLILVNPATHVNNFMVQPLSGMLNVLPDGLPTLLEDIFDFGFKQGDPLTGMLDALSNEFSVQRMGGVGGGMLRDVLAVSANLPTLSRMFPKDTLLWKLEMLKYAIASVNSHIYSVRAETLILLSGRDHWLLKEEDIDRYSRTLPKCIVRKLDDNGQFPLLEDGVDLATIIKCTCFYRRGKSHDHITDYIMPTTFELKQQVDDHRLLMDGTSPVMLSTLEDGTVVRSLEGLPSEGPVLYVGYHMILGFELAPMVIQLMTERNIHLRGLAHPMLFKNLQDSLVDTKMFDKYKIMGGVPVSHFNIYKLLREKAHVLLYPGGVREALHRKGEEYKLFWPERSEFVRVASKFGAKIVPFGVVGEDDICEIVLDSNDQRNIPILKDLMEKATKDAGNIREGDESELGNQECYFPGLVPKIPGRFYYYFGKPIETAGKEKELKDKEKAQELYLQVKSEVEQCIDYLKVKRESDPYRHLLPRMLYQASHGWSSEIPTFDL
Acyltransferase involved in fatty acid phytyl ester synthesis in chloroplasts, a process required for the maintenance of the photosynthetic membrane integrity during abiotic stress and senescence . Exhibits phytyl ester synthesis and diacylglycerol acyltransferase activities with broad substrate specificities, and can employ acyl-CoAs, acyl carrier proteins, and galactolipids as acyl donors .
Q9LW26
Q9CS42
PRPS2_MOUSE
Phosphoribosyl pyrophosphate synthase II
Mus
MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVDRMVLVGDVKDRVAILVDDMADTCGTICHAADKLLSAGATKVYAILTHGIFSGPAISRINSAAFEAVVVTNTIPQEDKMKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
Q9CS42
A9M3X8
RL11_NEIM0
50S ribosomal protein L11
Neisseria
MAKKIIGYIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAATQSMEPGLPIPVVITAFADKSFTFVMKTPPASILLKKAAGLQKGSSNPLTNKVGKLTRAQLEEIAKTKEPDLTAADLDAAVRTIAGSARSMGLDVEGVV
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
A9M3X8
A3MI96
RS15_BURM7
30S ribosomal protein S15
pseudomallei group
MSVADIKKSEVVAQFARGANDTGSPEVQVALLTARITELTGHFKTHAKDHHSRRGLLRMVSRRRKLLDYLKGKDADRYRALIEKLGLRK
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
A3MI96
Q0BU46
PANC_GRABC
Pantoate-activating enzyme
Granulibacter
MHLARTLPTLQQAVHQLRHAGKRIAFVPTMGALHEGHQSLVRAAIAQDYAVVTSVFVNPTQFGPSEDLARYPRDEKGDIAILERTGCSIAWLPDVDTMYPPGDATGFVMGGPALGWEGARRPGHFNGVAQVVAKLFGQVRPDAAFFGEKDWQQLQVIRRLTADLLLPVAIHGVPTQREEDGLAMSSRNRFLSPEERAIAPLLFRTLLQAGHALSSSPDAEEICKNAIAALNGQGFDVDYFALIEGSSLSSIAILPEGDDWRLITAARLGSVRLLDNLGRAELARFRA
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q0BU46
B2VG94
RL10_ERWT9
50S ribosomal protein L10
Erwinia
MALNLQDKQAIVAEVSEVAKGALSAVVADSRGVTVDKMTELRKAGREAGVYMRVVRNTLLRRVVEGTQFECLKDTLTGPTLIAYSMEHPGAAARLFKEFAKANAKFEVKAAAFEGELISAAQIDRLATLPTYDEAIARLMATMKEAAAGKLVRTLAAVRDQKEATAA
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
B2VG94
D7A0Y0
PY2CR_STAND
Delta(1)-pyrroline-2-carboxylate reductase
Starkeya
MDEPVRLSLAEVHVLCRDTLVAAGLGEEHAQAIARSITRAEADECHSHGLYRLIGYVASVRSGKAERHALPALARATPAVLRVDAKHGFAPLAVETGVPALIAAAKEIGIAALAIHDCYHFSALWADIEPAVEAGLAAWCFTVGQCCVAPAGGTTPLLGTNPFAFGWPGPSGRPFIFDFATSAAARGEIELKRRGGEKIPPGWAVGPDGAPTTDPAAALAGALLPFGGHKGSALSMMVELIAGPLIGDLTSRQSKAVENGDGGPPLGGELFIAIDPAVFGTGNLSSRLADADELFALAKAQPGVRLPSERRYQARERSRTNGIAVPAALFAELQALGPRGS
Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts cis- and trans-3-hydroxy-L-proline (c3LHyp and t3LHyp) to L-proline, which would allow S.novella to grow on c3LHyp or t3LHyp as a sole carbon source.
D7A0Y0
Q5YYX3
SEPF_NOCFA
Cell division protein SepF
Nocardia
MSTLHKFKAYFGMVPLEDYEDDYVDDRAPRASERGGARGPRPYSERAGYGADRYGEDRYSADRFGPERFGAERFGPDRFGADRFDEDADYPEPAYKSYKSGYPVARRDDYPEDAYGEDRYEAPRRPTRIDAAPSSGRFRAGGGAPMLRGATRGALAVDPEAEERRLEERMRPEPVVARRPGIFEDGGPLSKITTLRPRDYSEARIIGERFREGNPVIMDLVELSNADAKRLVDFAAGLAFALRGSFDKVATKVFLLSPADVDVSAEERRRIAETGFYNQK
Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
Q5YYX3
B7L7A1
AES_ECO55
Acetyl esterase
Escherichia
MKPENKLPVLDLISAEMKTVVNTLQPDLPSWPATGTIAEQRQYYTLERRFWNAGAPEMATRAYMVPTKYGQVETRLFCPQPDSPATLFYLHGGGFILGNLDTHDRIMRLLASYSQCTVIGIDYPLSPEARFPQAIEEIVAACCYFHQQAEDYQINMSRIGFAGDSAGAMLALASALWLRDKQIDCGKIAGVLLWYGLYGLRDSVTRRLLGGVWDGLTQQDLQMYEEAYLSNDADRESPYYCLFNNDLTREVPPCFIAGAEFDPLLDDSRLLYQTLAAHQQPCEFKLYPGTLHAFLHYSRMMKTADEALRDGAQFFTAQL
Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.
B7L7A1
A6Q6N9
RL13_SULNB
50S ribosomal protein L13
unclassified Sulfurovum
MKMTKVLKPSEVQRDWVLIDAEGKTFGRILTEVATLLRGKHKPSFTPNVDCGDYVVIINAEKAKFTGVKLEDKEYFTHSGYFGSTKSKKLGDMLENHTEKLYKLAVRGMLPKTTLGRQMLKKLKVYAGAEHPHTAQINKEA
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
A6Q6N9
Q2NRM1
RNH2_SODGM
Ribonuclease HII
Sodalis
MTESFIYPAATLIAGVDEVGRGPLVGAVVTAAVILDPARPVLGLADSKKLSEKRREALYEEITRYALAWSVGRAEASEIDSINIYQATLLAMQRAVAALAVVPDFVLVDGNRCPLLPMPSQAIVKGDSRVAEISAASIIAKVTRDREMAALHLQFPEYGFAQHKGYPTAFHLEKLALHGATVHHRRSFAPVRRVLELA
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q2NRM1
Q9LXB8
PLPK1_ARATH
Protein Pro-Glu-Leu|Ile|Val-Pro-Lys 1
Arabidopsis
MALMKKSLSAALLSSPLLIICLIALLADPFSVGARRLLEDPKPEIPKLPELPKFEVPKLPEFPKPELPKLPEFPKPELPKIPEIPKPELPKVPEIPKPEETKLPDIPKLELPKFPEIPKPELPKMPEIPKPELPKVPEIQKPELPKMPEIPKPELPKFPEIPKPDLPKFPENSKPEVPKLMETEKPEAPKVPEIPKPELPKLPEVPKLEAPKVPEIQKPELPKMPELPKMPEIQKPELPKLPEVPKLEAPKVPEIQKPELPKMPELPKMPEIQKPELPKMPEIQKPELPKVPEVPKPELPTVPEVPKSEAPKFPEIPKPELPKIPEVPKPELPKVPEITKPAVPEIPKPELPTMPQLPKLPEFPKVPGTP
Positive regulator of germination and plant growth.
Q9LXB8
Q9VLA1
B3G2S_DROME
UDP-glucuronosyltransferase S
Sophophora
MSSARLLESQTSDEDNEDIERRPHQSHSRSCSNNTTPTHPPHPMVRKGGVARRICLIGGALFLLLVALCYLTLSGDTRLGGSEDSEEGSHHGLDSMNFRPLNETVHICSESYEDRRQFMQDKPQSDYVQLPVIYFVTPTYPRREQIPELTRLAHTLLHIPRLHWLVADDQEKCNDYMDTLLYRFGMPFTHMVSPMPSKFRNEKPAPRGVANRRAALQWIRQHNLTNGILYFGDDDNTYDLRLFSEIRKTQRVSMFPVGLIADYGVSGPVVRKGKVVAFLDSWVAGRRWPVDMAGFAVNLEYMAQYPYVNMPYKPGYEEDLFLRSIGLQMNLIEPRGNNCTEILVWHTQTKSKKLGMVRLESKYLDDRSNLGALLHNLKLMGVTSTTESEGRNALISKNGRENPHSKILS
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins. Enzyme has a broad specificity.
Q9VLA1
Q8MLZ7
IDGF3_DROME
Imaginal disk growth factor protein 3
Sophophora
MTGSLWLSLALSLAVLAQFKVSAAPNLVCFYDSQGSQRQGLAQFSMIDIELALQFCTHLVYGYAGVNADNYEMQSINKRLDLEQRHLAQITSMKERYPHIKFLLSVGGDADTNEGNQYIKLLESGQQGHRRFIESARDLVRRYNFDGLDLALQLPRNKPRKVHGDVGSAWKSFKKFFTGDFIVDTESETHKGQVTALIKDLSAALKQNDLLLSLTVLPNVNSSWYYDAPSIAPSLDFINLGTFDFLTPQRNPEEADFSAPTYEAVGQNRLGHYNLNFQMEHWLLQRVPANKINIGIATYGRSWKMSKDSGDSGMPVVPSTQGPAPAGPQSKQEGLLNWAEICSLMPNPSNSNARGPNAPVKRVVDPTKRYGSYAFRAADENGDHGLWISYDDPDSASSKAMYARARNLGGVALFDLTQDDFRGQCTNDRFPMLRAIKYRLL
Cooperates with insulin-like peptides to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex.
Q8MLZ7