accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q043R6
TRMFO_LACGA
Folate-dependent tRNA(M-5-U54)-methyltransferase
Lactobacillus
MVKNVTVIGGGLAGSEAAWQLAKRGIEVELYEMRPKKTTPAHETANFAELVCTNSMRSNQLSNAVGLLKEEMRQLDSLIMKAADETAVPAGGALAVDRDKFSSVVTQTLKDLPNVHVHEEEITKIPKDGITIIATGPLTSDTLAEQIKDFCGTDSLHFFDAAAPIVAASSIDRDIVYKKSRYDKGEAAYLNCPMTKEEFFNFYKNLVSAETATLHGFEDKNVFEGCMPIEVMAKRGEKTMLFGPLKPVGLEDPKTGKTPYAVVQLRQDNAASTMYNIVGFQTHLKYGEQKRVFSMIPGLENAKFVRYGKMHRNTYIASPEVLNANYEARKQAGLFFAGQMTGVEGYVESAGSGLIAGINAARETVGEETLVFPKSTALGSMAHYITTTSAKHFQPMNASYALLPKLDYKVRNKQERHLEISKRALKDLETFKEEKKLD
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
Q043R6
A9N0K6
THIC_SALPB
Thiamine biosynthesis protein ThiC
Salmonella
MSTTTLTRREQRAKAQHFIDTLEGTAFPNSKRIYVTGSQHDIRVPMREIQLSPTLIGGSKDNPQFEENEAVPVYDTSGPYGDPEVAINVQQGLAKLRQPWIDARNDSEELDDRSSAYTRERLADDGLDDLRFTGLLTPKRAKAGKRVTQLHYARQGIVTPEMEFIAIRENMGRERIRSEVLRHQHPGMNFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLLEQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHKENFLFEHFREICEICAAYDVSLSLGDGLRPGSIQDANDEAQFSELHTLGELTKIAWEYDVQVMIEGPGHVPMHMIQRNMTEELESCHEAPFYTLGPLTTDIAPGYDHFTSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPFTARAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAAAQAIEVGMADMSENFRAKGGEIYLKREEA
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
A9N0K6
Q0P5I6
PR38A_BOVIN
Pre-mRNA-splicing factor 38A
Bos
MANRTVKDAHSIHGTNPQYLVEKIIRTRIYESKYWKEECFGLTAELVVDKAMELRFVGGVYGGNIKPTPFLCLTLKMLQIQPEKDIIVEFIKNEDFKYVRMLGALYMRLTGTAIDCYKYLEPLYNDYRKIKSQNRNGEFELMHVDEFIDELLHSERVCDIILPRLQKRYVLEEAEQLEPRVSALEEDMDDVESSEEEEEEDEKLERVPSPDHRRRSYRDLDKPRRSPTLRYRRSRSRSPRRRSRSPKRRSPSPRRERHRSKSPRRHRSRSRDRRHRSRSKSPGHHRSHRHRSHSKSPERSKKSHKKSRRGNE
Involved in pre-mRNA splicing as a component of the spliceosome.
Q0P5I6
B8H729
PAND_PSECP
Aspartate 1-decarboxylase alpha chain
Pseudarthrobacter
MNRTMFKSKIHRATVTHADLHYVGSVTVDLDLLEAADILPGELVSIVDITNGARLETYTIAGERGSGVIGINGAAAHLMHENDLVILITYAQMTTEEAKAYEPKVVHVDQDNRIIQLGNDPAEGIAPGMTRPPFALNNAAL
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
B8H729
Q66KB7
UEVLD_XENTR
EV and lactate/malate dehydrogenase domain-containing protein
Silurana
MEFSAETLRQQLGKYKFRDLTIEELKDLNRTFPSFIFSMETYTFRDGSQKDLLNLTGTVPMKHQGTTYNIPICLWILDSHPFAPPLCFLKPSGNMGIRVGRHIDAQGRIYLPYLQNWSHPKSTVTGLIREMAVKFEEELPLYSLSAEDGARQRELLSYIAQVTDGVSSMDVKAPSRAKVTVIGGGDMALACLLAVSAKGTAGKLLLLDPTDGEAAGGAAADLEIFSLPNVQVTKDFSAIAGSAIVIVTVNSWSNSQSYVGVLQSNVELLRGILPAVAHHCPKCLLLVASQPVEIMTYATWKLSGFPHNRVLGIGCNLDSGRFRHVIEKLADSEEGAQGAWIIGEQSDNKVAVWGAPDSSANRQTPCKLYPKIFQEQLTSRALEILKGKGQRSWSVGLSVADITDTLVQNKGKVHSVSALCKGQFGVQEEVFLSIPCVLGSAGVTGAVQTLQDEAQIWETLQRSAAAIESVQQQLRL
Possible negative regulator of polyubiquitination.
Q66KB7
O88588
PACS1_RAT
Phosphofurin acidic cluster sorting protein 1
Rattus
MAERGGAGGGPGGAGGGSSQRGSGVAQSPQQQPPQQPSQPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIILPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKVKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKADLQGSASPSKVEGTHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGSQSYLSSILRFFVKSLASKTPDWLGHMRFLIVPLGSHPVAKYLGSVDSRYSSTFLDSAWRDLFSRSEPPVSEPLDVVGRVMQYVNGATTTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHAGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKPT
Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits.
O88588
B4S9J3
HYPA_PROA2
Hydrogenase maturation factor HypA
Prosthecochloris
MHEMSIALSVVDAITARAREEQAEKVTAIELVAGKLSGVEIESLKFCFSAAVRGTIMEDAELMVTVPLSEGLCEVCGERFAVDGYYTQCPSCGSYKVRIVSGKELSIRSITLE
Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
B4S9J3
A7H7I2
GLMU_ANADF
Glucosamine-1-phosphate N-acetyltransferase
unclassified Anaeromyxobacter
MSHSPTPLAAIVLAAGKGTRMKSQKAKVLHEVGGRPLAWFPTRRALEIGANPVVAVVGHQAEAVEAALAATLPGAPLRFAVQREQLGTAHAVLSAREALGRYQGAVLILSGDTPLLRAETLSRVVAARAGATLSLATMRLADPHGYGRIVRDPAGTPARVVEEKDATDAERALDEVNAGLYCADAAFLWEALSKVGSANAQREFYLTDLVAMAARAGGVVAVPVPPEEASGVNDREELARAGRVLLRRRASELMRSGVTIEDPERFDCDEGVEIGADAVIEPNVRLKGRTRIGAGCRLGAGAILTDAVLADGVTVKPYTVIEEATVAARAILGPFSRLRPGSDIGEEAHVGNFVETKKARLGKGAKANHLTYLGDATIGAGANVGAGTITCNYDGEKKHPTTIGEGAFIGSDSILVAPIEIGAGAYVAAGSTLTESVPPGALALGRAKQVTKEGWVARRKAEAQNKGAAEAAPAPSPADSPRGGRAS
Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.
A7H7I2
Q61080
FOXF1_MOUSE
Hepatocyte nuclear factor 3 forkhead homolog 8
Mus
MSAPDKQQPPHGGGTGGGGGAGGQAMDPAAAGPTKAKKTNAGVRRPEKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPVYSMVNGLGFNHLPDTYGFQGSGGLSCAPNSLALEGGLGMMNGHLAGNVDGMALPSHSVPHLPSNGGHSYMGGCGGSAAGEYPHHDSSVPASPLLPAGAGGVMEPHAVYSSSAAAWPPAASAALNSGASYIKQQPLSPCNPAANPLSGSISTHSLEQPYLHQNSHNGPAELQGIPRYHSQSPSMCDRKEFVFSFNAMASSSMHTTGGGSYYHQQVTYQDIKPCVM
Probable transcription activator for a number of lung-specific genes.
Q61080
P82874
TO203_ARATH
Translocase of outer membrane 20 kDa subunit 3
Arabidopsis
MDTETEFDRILLFEQIRQDAENTYKSNPLDADNLTRWGGVLLELSQFHSISDAKQMIQEAITKFEEALLIDPKKDEAVWCIGNAYTSFAFLTPDETEAKHNFDLATQFFQQAVDEQPDNTHYLKSLEMTAKAPQLHAEAYKQGLGSQPMGRVEAPAPPSSKAVKNKKSSDAKYDAMGWVILAIGVVAWISFAKANVPVSPPR
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.
P82874
Q4PEF9
H2A_USTMA
Histone H2A
Ustilago
MSSGGKSGGKAGDASSKAQSRSAKAGLQFPVGRIHRLLRKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKSRIIPRHLQLAIRNDEELNKLLGGVTISQGGVLPFIQSELLPAKSGKPKKAGGSQDI
Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q4PEF9
Q6MQU0
TRMB_BDEBA
tRNA(m7G46)-methyltransferase
Bdellovibrio
MALNGEYAHVAFDELRAPLNKGKWRSDVFKADAAMPLDVEVGTGNGTYFAHHAKTHSDRLLVGLELKYKPLIQSIRRAVNAGCKNAAITRFHAFNIDHLFAEGEIDNVYIHFPDPWTSPKKPKNRFVCKENLELLFRLQKPGSFINFKTDSLVYFLWAMDEIRQSPYKIIFETQDLHNSDMKDQNFETAFEKIFLREGIKINFVRLQKI
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Q6MQU0
P73788
PSTB3_SYNY3
Phosphate-transporting ATPase 3
unclassified Synechocystis
MTNLSGSMPSSTAADLQPALRVEGLGFYYGTKKVLEGVTMAIPVGKVTAMIGPSGCGKSTLLKAFNRIAELEGRVKVTGKIEFFGQNIYDQKVNINSLRREIGMVFQRPNPFPTSIYDNIVYGVKLCCNVSRAELDEIVERSLTRAVLWDEVKDSLKKSALGLSGGQQQRLCIARALAVNPKVLLMDEPCSALDPISTLKIEELINSLRENVTITIVTHNMQQALRVSDYTAFFNTDESRIGQLVEFDTTQNIFSSPQETQTRDYVAGRFG
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
P73788
P02128
HBE_CHICK
Hemoglobin epsilon chain
Gallus
MVHWSAEEKQLITSVWSKVNVEECGAEALARLLIVYPWTQRFFASFGNLSSPTAIMGNPRVRAHGKKVLSSFGEAVKNLDNIKNTYAKLSELHCDKLHVDPENFRLLGDILIIVLASHFARDFTPACQFAWQKLVNVVAHALARKYH
Beta-type chain found in early embryos.
P02128
Q329T0
MNMG_SHIDS
Glucose-inhibited division protein A
Shigella
MFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQMSCNPAIGGIGKGHLVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQQAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVGTFLDGKIHIGLDNYSGGRAGDPPSIPLSRRLRELPLRVGRLKTGTPPRIDARTIDFSVLAQQHGDNPMPVFSFMGNASQHPQQVPCYITHTNEKTHDVIRSNLDRSPMYAGVIEGVGPRYCPSIEDKVMRFADRNQHQIFLEPEGLTSNEIYPNGISTSLPFDVQMQIVRSMQGMENAKIVRPGYAIEYDFFDPRDLKPTLESKFLQGLFFAGQINGTTGYEEAAAQGLLAGLNAARLSADKEGWAPARSQAYLGVLVDDLCTLGTKEPYRMFTSRAEYRLMLREDNADLRLTEIGRELGLVDDERWARFNEKLENIERERQRLKSTRVTPSAEAAAEVNAHLTAPLSREASGEDLLRRPEMTYEKLTTLTPFAPALTDEQAAEQVEIQVKYEGYIARQQDEIEKQLRNENTLLPATLDYRQVSGLSNEVIAKLNDHKPASIGQASRISGVTPAAISILLVWLKKQGMLRRSA
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q329T0
O34817
NAGR_BACSU
N-acetylglucosamine utilization regulator
Bacillus
MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQFGISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGSRLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNESHFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNGTAFEHAKSVYRGDRYTFVHYMDRLS
Main transcriptional repressor of genes involved in N-acetylglucosamine (GlcNAc) transport and utilization . Represses the expression of the nagAB and nagP operons by binding directly within their upstream regions . Binds to the DNA consensus sequence 5'-ATTGGTATAGACAACT-3' . Also acts as a weak repressor of mapB expression .
O34817
Q0MQ95
NDUA3_GORGO
NADH-ubiquinone oxidoreductase B9 subunit
Gorilla
MAARVGAFLKNAWDKEPVLVVSFVVGGLAVILPPLSPYFKYSVMINKATPYNYPVPVRDDGNMPDVPSHPQDPQGPSLEWLKKL
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Q0MQ95
Q8G8B6
CARAA_PSERE
Carbazole 1,9a-dioxygenase, terminal oxygenase component CarAa
Pseudomonas
MANVDEAILKRVKGWAPYVDAKLGFRNHWYPVMFSKEIDEGEPKTLKLLGENLLVNRIDGKLYCLKDRCLHRGVQLSVKVECKTKSTITCWYHAWTYRWEDGVLCDILTNPTSAQIGRQKLKTYPVQEAKGCVFIYLGDGDPPPLARDTPPNFLDDDMEILGKNQIIKSNWRLAVENGFDPSHIYIHKDSILVKDNDLALPLGFAPGGDRKQQTRVVDDDVVGRKGVYDLIGEHGVPVFEGTIGGEVVREGAYGEKIVANDISIWLPGVLKVNPFPNPDMMQFEWYVPIDENTHYYFQTLGKPCANDEERKNYEQEFESKWKPMALEGFNNDDIWAREAMVDFYADDKGWVNEILFEVDEAIVAWRKLASEHNQGIQTQAHVSG
Part of the multicomponent carbazole 1,9a-dioxygenase (CARDO), that converts carbazole (CAR) into 2-aminobiphenyl-2,3-diol. Catalyzes the dioxygenation at the angular (C-9a) and adjacent (C-1) positions of carbazole to yield a highly unstable cis-hydrodiol intermediate which is spontaneously converted to 2-aminobiphenyl-2,3-diol. It is also able to attack the angular position adjacent of hetero atom of heterocyclic aromatic compounds such as polychlorinated dibenzo-p-dioxin (DD) and dibenzofuran (DBF). It was also shown that CARDO has the ability to metabolize biphenyl and polycyclic aromatic hydrocarbons, such as naphthalene and phenanthrene.
Q8G8B6
A0R2E6
GPGS_MYCS2
Glucosyl-3-phosphoglycerate synthase
Mycolicibacterium
MGHRWLTDHSWNRPSWTVADLEAAKAGRTVSVVLPALNEEETVGSVVETIKPLLGGLVDELIVLDSGSTDETEIRAVAAGAKVVSREAALPEVPPQPGKGEVLWRSLAATTGDIIAFVDSDLIDPDPMFVPKLLGPLLTCDGVHLVKGFYRRPLKVSGAEDANGGGRVTELVARPLLASLRPELNCVLQPLGGEYAGTRELLTSVPFAPGYGVEIGLLVDTYDRLGLDGIAQVNLGVRAHRNRPLTELASMSRQVIATLLSRCGISDSGVGLTQFFADGDDFTPRVSSVSLADRPPMTTLRPR
Involved in the biosynthesis of 6-O-methylglucose lipopolysaccarides (MGLPs) . Catalyzes the transfer of the glucose moiety from a nuleotide sugar such as UDP-alpha-D-glucose to the position 2 of 3-phospho-D-glycerate (3-PGA) to form glucosyl-3-phosphoglycerate (GPG). It can use UDP-glucose, ADP-glucose and GDP-glucose as sugar donor substrates with decreasing affinity and with 3-PGA as an acceptor. D-glycerate can only be an acceptor with ADP-glucose and at a very low rate .
A0R2E6
Q185S7
PYRH_CLOD6
Uridine monophosphate kinase
Clostridioides
MDKPMYKRVLLKLSGEALAGERGFGINNDVVNDIAIAIKKIQEIGVEVAVVVGGGNFWRGRTSEGMDRTTADYIGMLATVMNAMALQDALENIDVATRVQTAIDMRQIAEPYIRRRAVRHLEKERVVIFGAGTGNPYFTTDTTAALRAAEMEAEVILLAKNVDAVYDKDPKVHADAKKFTELSYMEVIQKELKVMDSTATSLCMDNKIPIKVFELTTENIIRAVKGENIGTTVK
Catalyzes the reversible phosphorylation of UMP to UDP.
Q185S7
Q9FLB5
LAC12_ARATH
Urishiol oxidase 12
Arabidopsis
MTTVHTFSILLFFCSLFSASLIIAKVQHHDFVIQETPVKRLCKTRNAITVNGMFPGPTLEVNNGDTLEVKVHNRARYNITIHWHGVRQIRTGWADGPEFVTQCPIRPGKSYTYRFTIQGQEGTLWWHAHSSWLRATVYGALIIHPTPGSSFPFPKPDRQTALMLGEWWNANPVDVINQATRTGAAPNISDAYTINGQPGDLYNCSTKETVVVPINSGETSLLRVINAALNQPLFFTVANHKLTVVGADASYLKPFTTKVLMLGPGQTTDVLLTADQPPKRYYIAARAYQSAQNAPFDNTTTTAILQYKKTTTTSKPIMPVLPAFNDTNTVTSFSRKFKSLRNVVVPKTIDDNLFFTIGLGLDNCPKKFPKSRCQGLNGTRFTASMNNVSFVLPSNFSLLQAHSNGIPGVFTTDFPSKPPVKFDYTGNNISRALFQPVKGTKLYKLKYGSRVQVVLQDTNIVTSENHPIHLHGYDFYIVGEGFGNFNPKKDTSKFNLVDPPLRNTVAVPVNGWAVIRFVADNPGVWLMHCHLDVHIKWGLAMAFLVDNGVGELETLEAPPHDLPIC
Lignin degradation and detoxification of lignin-derived products.
Q9FLB5
Q7MA42
NUOI_WOLSU
NDH-1 subunit I
Wolinella
MDLKQKYIFIEGTNCPVTVRGRLLQVFRRSVSGELFKGLWLVLREMLRFNIHTTQYPKEKLPLSPRYRAIHELLRLLESGNERCIGCGLCEKICISNCIRMETSYGEDGRKKVHEYTINFGRCIFCGFCAEVCPELAIVHGGRYENASEQRAHFGLKEDMLTPMERFMNQGQKEFPGFGALSQDADSKVKKTPLAYFTPKGEENV
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q7MA42
Q4I5Z5
CGR1_GIBZE
rRNA-processing protein CGR1
Fusarium
MSDTENTNLTPAPAAEKTLGMRKNGKQWHAPKKAFRPTSGLKSYEKRSQERAIMIQVKAKEKEMKEEKEEERQRKVQAIKEKRAKKEEKERYEKMAEKMHKKRVERLKRKEKRNKLINS
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
Q4I5Z5
P0DSN9
SAA4_PIG
Serum amyloid A-4 protein
Sus
MKLFIGLIFCSLVMGVSSDGWFSFFKEAVQGASDLWRAYWDMKEANYQNSGRYFRARGNYEAAQRGPGGIWAAKIISNVGEYFQGLLQYLGSSSEREEDQVSNRRAEEWGRSGQDPDHFRPAGLPKKY
Major acute phase reactant.
P0DSN9
Q8N531
FBXL6_HUMAN
FBL6A
Homo
MAAPASRQVRRRARAAPRPRSAEDWWWDRLAPRGSGYHLLQSDSMLLVLSEPGPARPRAQRRASRRTPRQPPRGPSAAAKPKAGLRSEAAAAPAPAPAPTPTPEEGPDAGWGDRIPLEILVQIFGLLVAADGPMPFLGRAARVCRRWQEAASQPALWHTVTLSSPLVGRPAKGGVKAEKKLLASLEWLMPNRFSQLQRLTLIHWKSQVHPVLKLVGECCPRLTFLKLSGCHGVTADALVMLAKACCQLHSLDLQHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLGSCCPQLQVLEVSTGINRNSIPLQLPVEALQKGCPQLQVLRLLNLMWLPKPPGRGVAPGPGFPSLEELCLASSTCNFVSNEVLGRLLHGSPNLRLLDLRGCARITPAGLQDLPCRELEQLHLGLYGTSDRLTLAKEGSPFLTQKWCHTLRELDLSGQGFSEKDLEQALAAFLSTPGGSHPALCSLNLRGTRVTPSTVSSVISGCPGLLYLNLESCRCLPRGLKRAYRGLEEVQWCLEQLLTSPSPS
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Q8N531
A1KVH5
ACPS_NEIMF
4'-phosphopantetheinyl transferase AcpS
Neisseria
MIYGIGTDIVSLKRIIRLNKKFGQAFAGRILTPEELLEFPQAGKPVNYLAKRFAAKEAFAKAVGTGIRGAVSFRNIGIGHDALGKPEFFYGPALSKWLEEQGISRVSLSMSDEEDTVLAFVVAEK
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
A1KVH5
Q9XP73
CYB_SMIYO
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Sminthopsis
MINLRKTHPLMKIINHSFIDLPAPSNISAWWNFGSLLGICLVIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVMLLLTVTATAFVGYVLPWGQMSFWGATVTTNLFSAIPYIGQTLVEWAWGGFSVDKATLTRFFALHFLLPFVIAGLTLVHLTFLHETGSNNPLGIPSDCDKIPFHPYYSIKDILGLMFLLLVLLSLALFSPDLLGDPDNFSPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASILILLVIPFLHTANQRSMMFRPISQTLFWILTANLITLTWIGGQPVEQPFIIIGQPASILYFPLIHHPMPSAGLFENYMPKPKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q9XP73
Q9D3H2
OBP1A_MOUSE
Odorant-binding protein IA
Mus
MAKFLLLALTFGLAHAAMEGPWKTVAIAADRVDKIERGGELRIYCRSLTCEKECKEMKVTFYVNENGQCSLTTITGYLQEDGKTYKTQFQGNNRYKLVDESPENLTFYSENVDRADRKTKLLFILGHGPLTSEQKEKFAELAEEKGIPAGNIREVLITDYCPE
Binds the chemical odorant 2-isobutyl-3-methoxypyrazine.
Q9D3H2
Q3J8S9
RL6_NITOC
50S ribosomal protein L6
Nitrosococcus
MSRIADNPVSIPKGVEVTLSGDNDIKVKGAKGSLAFAIHPLIQVVQDGETLRFSAKSTDKRVNALRGTTRALINNMVQGVSQGFERRLQLVGVGYRAQLQGRKLVLSLGYSHPVEFTAPEGLTIEVPSPTEIIVKGYDKQQVGQAAANIRRFRPPEPYKGKGVRYADEVVVRKEAKKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q3J8S9
P16890
H2BL4_STRPU
Late histone H2B.L4
Strongylocentrotus
HASRATDGKKRRKRRKESYGIYIYKVLKQVHPDTGISSRAMSIMNSFVNDVFERIAGEASRLAQYNKKSTISSREVQTAVRLLLPGELAKHAVSEGTKAVTKYTTSK
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
P16890
Q9LKI5
XPF_ARATH
Ultraviolet hypersensitive 1
Arabidopsis
MALKYHQQIISDLLEDSNGGLLILSSGLSLAKLIASLLILHSPSQGTLLLLLSPAAQSLKSRIIHYISSLDSPTPTEITADLPANQRYSLYTSGSPFFITPRILIVDLLTQRIPVSSLAGIFILNAHSISETSTEAFIIRIVKSLNSSAYIRAFSDRPQAMVSGFAKTERTMRALFLRKIHLWPRFQLDVSQELEREPPEVVDIRVSMSNYMVGIQKAIIEVMDACLKEMKKTNKVDVDDLTVESGLFKSFDEIVRRQLDPIWHTLGKRTKQLVSDLKTLRKLLDYLVRYDAVSFLKFLDTLRVSESYRSVWLFAESSYKIFDFAKKRVYRLVKASDVKSKEHVKNKSGKKRNSKGETDSVEAVGGETATNVATGVVVEEVLEEAPKWKVLREILEETQEERLKQAFSEEDNSDNNGIVLVACKDERSCMQLEDCITNNPQKVMREEWEMYLLSKIELRSMQTPQKKKQKTPKGFGILDGVVPVTTIQNSEGSSVGRQEHEALMAAASSIRKLGKTTDMASGNNNPEPHVDKASCTKGKAKKDPTSLRRSLRSCNKKTTNSKPEILPGPENEEKANEASTSAPQEANAVRPSGAKKLPPVHFYALESDQPILDILKPSVIIVYHPDMGFVRELEVYKAENPLRKLKVYFIFYDESTEVQKFEASIRRENEAFESLIRQKSSMIIPVDQDGLCMGSNSSTEFPASSTQNSLTRKAGGRKELEKETQVIVDMREFMSSLPNVLHQKGMKIIPVTLEVGDYILSPSICVERKSIQDLFQSFTSGRLFHQVEMMSRYYRIPVLLIEFSQDKSFSFQSSSDISDDVTPYNIISKLSLLVLHFPRLRLLWSRSLHATAEIFTTLKSNQDEPDETRAIRVGVPSEEGIIENDIRAENYNTSAVEFLRRLPGVSDANYRSIMEKCKSLAELASLPVETLAELMGGHKVAKSLREFLDAKYPTLL
Seems to be involved in nucleotide excision repair (NER) of damaged DNA (dark repair mechanism). Involved in repair of UV light, and probably oxidative damage. The UVH1/RAD1-ERCC1/RAD10 complex may act as an endonuclease making DNA incision 5' to the lesion site. In vitro, is implicated in double strand breaks (DSBs) repair and is required for homologous recombination in the presence of non-homologous overhangs. May mediate the induction of a DNA-damage sensitive cell-cycle checkpoint during the G2 phase.
Q9LKI5
Q75JL2
RECAM_DICDI
Recombinase A homolog
Dictyostelium
MSINKILSSTYKITQRSNNNNILFNGLKINSFSLCNTKTNLFTNKTNINLYNNYSKSSKSGKKSKKDEDDEDGEIETSKTSKKSASSSSMENVLKELEKSFGKGTLMKLGSQFSTQKVEVIPSGSMGLDIALGVGGLPKGRVTEIFGPESSGKTTLALHVIAQAQKAGGNCTFIDAEHALNPQWAARLGVNLDELFVSQPDNGEQALEIVDSLLRSKTMSVIVVDSVAALVPRVEIEGEMGDSHLGVQARLMSQALRKLSPTLKDSNCVLIFINQIRMKIGVMFGNPEVTSGGNALKFFSSIRIDIRKVGTVKKGDDIIASQVKAKVVKNKLAPPFKEAIFDIDFQSGINKTGEIIDLAVAEGIIDKMGSWYSYNDIKLDQGREKTKYLLEKTQPNLLVEIENKLRDKLIKSKPLINQQQEEEGNDQTSDEFDIENDDEIIEEDIDDETIKK
Involved in DNA recombination ability. Important for survival following exposure to DNA damaging agents.
Q75JL2
Q04732
ARP_EUGGR
Calcium-binding acidic-repeat protein
Euglena
MSHLWCWLFLVLCLACLVLSIEAKDSDGDGLLDVDEINVYFTDPYNADSDQDGLTDGLEVNRHQTHPQDKDTDDDSIGDGVEVNNLGTNPKDPDSDDDGLTDGAEVNLYRTDPLDADSTTTGCPMGGGAEVRHRPQNGDTDDDGLTDGAEVNVHRTNPQDGDSDDDGLSDGAEVNTYHSNPKDGDSDDDGVSDGAEVNPKLKDSDGDGLTDEEEIKLYRTDPFCADSDFDGLLDGEEVKVHKTNPLDGDSDDDGLGDGAEVTHFNTNPLDADSDNDGLDDGEEINVHGTDPEDPDSDNDGLNDGDEVNVYNTDPEEDDSDEDGVCDGAEVNVHHTNPKDEDSDNDGIPDGAEINTHKTDPNDEDSDDDGIADGAEVTLTDSDGDGLPDEDEVALYNTNPANADSDYDGLTDGAEVKRYQSNPLDKDTDDDGLGDGVEVTVGTDPHDATVTTTGSRTAVEINVHGSDPNDEDTDDDGLTDGAEVNLHRTDPEDADTDDDGLTDGAEVNTYRTNPKLADSDGDGLSDGAEVNTHKSDPNDGDSDDDGVPDAAEAKVKDSDGDGLSDTDEVRFRTNPKLADTDFDGLTDGAEILKHKTDPRNRDTDGDGVADGLEVNTYGSDPKDADTDDDGLTDGAEINVHDTNPTDADSDDDGLSDGAEVMTYHTNAKDGDSDDDGKADGAEVSASTDPWRSDHSV
May function as a calcium-binding protein.
Q04732
C9RZ55
SPL_GEOSY
Spore photoproduct lyase
unclassified Geobacillus
MKPFVPKLVYFEPEALSYPLGQELYEKFTQMGIEIRETTSHNQVRGIPGETELARYRNAKSTLVVGVRRTLKFDSSKPSAEYAIPLATGCMGHCHYCYLQTTLGSKPYIRVYVNLDDIFAQAQKYIDERAPEITRFEAACTSDIVGIDHLTHSLKKAIEFIGATDYGRLRFVTKYEHVDHLLDAKHNGKTRFRFSVNSRYVINHFEPGTSSFDARLQAARKVAGAGYKLGFVVAPIYRHDGWEQGYFELFQELARQLEGVDLSDLTFELIQHRFTKPAKRVIEQRYPKTKLDLDESKRKYKWGRYGIGKYVYRDKEARELEETMRSYIARFFPSAQVQYFT
Involved in repair of UV radiation-induced DNA damage during spore germination. Can repair thymine dimer 5-thyminyl-5,6-dihydrothymine (known as spore photoproduct (SP)) by in situ monomerization of SP to two thymines.
C9RZ55
Q9ZZY5
COX3_HIPAM
Cytochrome c oxidase polypeptide III
Hippopotamus
MTHQTHAYHMVNPSPWPLTGALSALLMSSGLTMWFHFNSLILLTTGLVTNILTMYQWWRDVIRESTFQGHHTPVVQKGLRYGMVLFIISEVLFFTGFFWAFYHSSLAPTPELGGCWPPTGINPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRKQMLQALFITIALGVYFTLLQASEYHEASFTISDGVYGSTFFVATGFHGLHVIIGSTFLIVCFLRQLKFHFTSDHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Q9ZZY5
Q1K4R6
ITPA_NEUCR
Nucleoside-triphosphate pyrophosphatase
Neurospora
MSAPSQARHIVNFITGNANKLGEVKAILEPAIQVENQALDLLEIQGTLEEVTLDKCRRAADLVQGPVLVEDTCLCFNALKGLPGPYIKWFMNSLGHEGLNNLLAAYEDKSAKAVCTFGYSAGPGHEPILFQGITDGKIVPPRGPPNFGWDAIFEYEGQTYAEMDKAEKNKISHRAKALAKLQEWFAKEMTA
Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Q1K4R6
B7UFP4
UBIG_ECO27
3-demethylubiquinone-8 3-O-methyltransferase
Escherichia
MNAEKSPVNHNVDHEEIAKFEAVASRWWDLEGEFKPLHRINPLRLGYIAERAGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIQVDYVQETVEEHAAKYAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKSWLMAVVGAEYILRMVPKGTHDVKKFIKPAELLGWVDQTSLKERHMTGLHYNPITNTFKLGPGVDVNYMLHTQNK
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
B7UFP4
Q74GA6
NUOC_GEOSL
NDH-1 subunit C
Geobacter
MAENNRAVIKLKEKFAASILDVREFRGEVTVTVAREKVVDICRFLKESLQYNLCTDVTAVDYLGKQEPRFMVVYNLYSIPNKDRLRLKAGVPDADCSIDTVSCVWNSANWLEREVYDLMGVQFNNHPDLRRILMTDDWVGHPLRKDYPLQGPDREPYKGRLS
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q74GA6
Q5LJ70
MIAB_BACFN
tRNA-i(6)A37 methylthiotransferase
Bacteroides
MNELTGADFKSATADDNKKLFIETYGCQMNVADSEVIASVMQMAGYSVAETLEEADAVFMNTCSIRDNAEQKILNRLEFFHSMKKKKKHLIVGVLGCMAERVKDDLIEHHHVDLVVGPDAYLTLPELIASVEAGEKAMNVELSTTETYRDVIPSRICGNHISGFVSIMRGCNNFCTYCIVPYTRGRERSRDVESILNEVADLVSKGYKEITLLGQNVNSYRFEKEGGEVVTFPMLLRLVAEAAPGIRVRFTTSHPKDMSDETLEVIAQVPNVCKHIHLPVQSGSSRILKLMNRKYTREWYLDRVAAIKRIVPDCGLTTDIFSGFHSETEEDHRESLSLMEACGYDAAFMFKYSERPGTYASKHLEDNVPEEIKVRRLNEIIALQNRLSAESNNRCIGKTYEVLVEGVSKRSRDQLFGRTEQNRVVVFDRGTHRIGDFVNVRITEASSATLKGEEVFS
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Q5LJ70
B1L935
RPOB_THESQ
Transcriptase subunit beta
unclassified Thermotoga
MKEISCGRRTRVSFGKSREPLPIPDLVEIQKISYRRFLEEGLLEVLKKFSPIYSQATRSDLKKSDRGFALEFVSTRIGEPVVDPLECKAKGLTYSVPIYATARLTDMKSGEMKEEEVFLGYIPYMTDRGTFIINGAERVVVNQIVVSPGLYFSSEYIDREEYGGYFLPSRGAWLEVILDPYDGVLYAGLDGKKVNLFLFLKTIGYEKDEDILSLYPTYLDADDEDSLLLHVGSILLEDIYDGDRKIAEKWDILTKDLAERILMIDDINQIKIVHPIAQNTFEKMLELVSSSGEEGEEEEEKTKIYGLNEVTVVDAYLEIFRRLRPEELPRINAAKRYLHDLFFNPERYDLSEVGRYKVNERLRNAYIRYLIEVEGEDPEEARKKVYNETSLVLKPLDIVLASRILFDYFERRYVNDFEIDSYELKNLIRIFKEEYLEKRKTAPYDLRKLVSVFRRNYGVTSDLGVFAAIRYVSNINKELPSIPFDTKDHLGNKRVRTVGELVQREFERLFARAQKAIQERLTLINSLSKVSIQSLINIKSIISTVNQFFAMNQLSQFMDQVNPLSELTHKRRVSAVGPGGLRRESKVFEARNVHYSQYGRLCPIETPEGANIGFITSLAIYAKIDEYGFLMTPYRKVVNGKVTDEVVYLRANEEEEYKIIPATTPVDEEGNIIPERVVARMGEDIRLVPKEEVDFMDVSTKQPFSVSASLIPFLEHDDASRALMGSNMQRQAVPLLKTEAPLVGTGMEWEAAKNSGYVVLAEHDGIVKEVDAARVVVHRTDENGNLMYDDKGNPVVDEYRLLKFVRSNQDTMINQKPIVNEGDFVKKGDPIADGPATDMGELALGRNILVAFMPWEGYNYEDAILVSQELLEEDVFTSIHIEVYETQARETRLGPEEITADIPNVSKELLKNLDENGIIRVGAYVVSDYGVGSQAILVGKVTPKGEGDTTPEEKIIRSVFGERGRDVKDTSLRLPHGVEGRVIRVDVYDQNDIAELGAGVLKLVRVYVASRKTLDIGDKLAGRHGNKGVVSNILPKEDMPFLPDGTPVQMVLNPLGIPSRMNVGQILETHLGWLAKLTGKWFATPVFEGAKEDEILRPLYEERKKRGLHLGDDENNPNGKVVLRDGRTGEPFDNPVVVGYMYMLKLIHIAKEKIHARSTGPYSLIHQQPLGGKSHFGGQRLGEMEVWALEAYGAAHTLAEMLTIKSDDIKGRNEAYKAILKNMNIPEPGVPESFRVLIKELRGLALDVRLYDENGNEIDIDKY
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B1L935
Q0I2W9
MNMC_HAES1
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Histophilus
MFTVTPAKIYLNQEKTPVSEQFNDVYFSNQDGLAESEYVFQQGNHLWERWIVYQEKHFVIAETGFGTGLNFLAVTSLFRQFRQQYPDFPLKRLFFISFEKYPLPKDQLQQIHRLYPQFSALSQQLCDYCLDAIQGCQRFHFAETTLDLWFGDIADNLPQLGDYMQNRIDAWFLDGFSPSKNPQMWNDKLYQQIFYYSKPQGTFATFTAASAVRKGLISAGFEVQKRKGYGKKRECLCGIKNSTQQQNAKFPWYLNQPASLLSEDIAIIGGGIASLFTALSLLKRGAKVTLYCEDEQLALNASGNKQGAFYPQLSDDDDRNIRFYVHAFFYALQQLQWAIKQGIEFEHEFCGVALCAYDHKSAVKLAKISSYQWSKSLYQNLNKEQLSEKIGLPLDCAGGFIPQGAWLAPRQFVQNAFSYLQQLGLEIKTSQKITALDYRNLQWVLTNEQNETFNHQVVVLANGYQITDFVQTAKLPLYPVRGQVSQIPTSANLLKLKSVLCYDGYLTPADKMKQSHCLGASHIRNNKDRHFSHQEQRENQQKIQQNLASTDTDKNMDWLQDIDISANIARIGVRCSVRDRVPIMGNVPHFEQQCLDYRNIFNLRRRKQPIPDAAQWKNLYLIGALGSRGLTSAALLGETLASLIYAEPLPLSEDILHNLSPNRSWIRKLLKGTEIK
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
Q0I2W9
Q1QZS5
METE_CHRSD
Methionine synthase, vitamin-B12 independent isozyme
Chromohalobacter
MALAHILGYPRIGANRELKKAVEAYWKGDIDQAELERRGQALRAEHWQASRDAGLDFVTVGDFAFYDQVLNVSAMLGAVPPRFGAIDGDVDLDTTFRMARGRAPSGTPAAACEMTKYFDTNYHYLVPELHAGQRFRVASTRLFDEVAEAQAAGHPVKVALLGPVSWLWLGKEKSAGLDRLTLLDDVLSVYGEILERLAAQGVEWVQLDEPALVQDLPRDWRQAFESAYNKLQSAPVKLLLATYFGALGDNLGLAAGLPVAGLHIDTVRAPEQLDAVLDRLPTYKVLSLGAIDGRNIWRADLAALRERLQVARARLGERLWISASCSLLHVPVDLDAETDLDAELKSWLAFARQKLDEIVTLAHLLDGRATPEDTARLEAATSALDARRQSPRIHKPAVGERLAAVSADDAERASPYATRAKAQHRHLDLPLFPTTTIGSFPQTQDIRAARRAFKSGELSRDDYEARMRDEIAHAVERQEALAIDVPVHGEPERNDMVEYFGELLDGFAFTRFGWVQSYGSRCVKPPVIFGDVSRPGPMTVRWSEYAQSLTDKPMKGMLTGPVTILQWSFVRDDQPRDATCRQIALSLRDEVADLEAAGIKIIQIDEPALREGLPLRQGEWQEYLDWAVKSFKLSAAVARDETQIHTHMCYSEFNDIIAAIAALDADVITIETSRSDMELLDAFQDFAYPNEIGPGVYDIHSPNIPEVEWMVSLMEKAAEKIPAERLWVNPDCGLKTRGWAEVEPALANMVEAARELRRRYG
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Q1QZS5
A2RKR1
LEUD_LACLM
Isopropylmalate isomerase
Lactococcus cremoris subsp. cremoris
MEKFTIYKGTSVPLMNDNIDTDQIIPKQFLKAIDKKGFGKNLFYEWRYSKDYEENPDFMLNKPQYRKASLLISGDNFGSGSSREHAAWALADYGFRAIIAGSYSDIFYNNSLKNGLLPIVQPKEALKSLAQLSSQEEITIDLPHQLIQTSTENFYFEIDPIWKDKLINGLDDIGITLQYEQAITAYEQKHQ
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
A2RKR1
Q1D0S7
MRAY_MYXXD
UDP-MurNAc-pentapeptide phosphotransferase
Myxococcus
MLYLLYEVIQNSEAGRVLNFLRYPTFRIIAAGVFALLLGMLIGPKLIARLRLKQHGQSNVREDTPDSHQKKKGTPTMGGALILLCIAAGTLLFADLKSRAVWVMLLLTLGYGFIGFLDDWLKLSKRNSKGLAGRKKMVLQTFFFLVAVFGLLTTWTLPDGSFGPTLLINTKLTLPFIPTRWFNPDLGWFYVFFAWIVVVGTSNAVNLTDGLDGLAIVPTIVSAITFAVLCYVAGTTLSIADYEVVGGASKLVATPLYQYLGILQVPGGAELAVFCAAIVGAGISFLWFNTYPASVFMGDIGSLALGGALGGLAMLSKNEVVSAIIHGIFFAEILSVMIQVTSFKMTGKRVFKMAPVHHHFELKGMAEPKIIVRFWIVSILCGGVALLSLKLR
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Q1D0S7
B0BU72
TRPB_ACTPJ
Tryptophan synthase beta chain
Actinobacillus
MSDTLLNPYFGEFGGMYVPEILVPVLKQLEETFVAAQNDPLFQAEFTDLLKNYAGRPTALTLCRNLTKGSKTKLYLKREDLLHGGAHKTNQVLGQALLAKRMGKTRIIAETGAGQHGVATALACAMLDLPCVIYMGAKDVERQSPNVFRMRLMGAEVIPVQKGSCSLKDACCEAMRDWAANYETTHYLIGTAAGPHPFPTMVREFQKMIGEETKRQILEKENRLPDAVIAAVGGGSNAIGMFAGFIEEKSVQLIGVEPAGKGIETGEHGAPLKHGTTGIYFGMKSPIMQTKDGQIEESYSISAGLDFPSVGPQHAYLNSIGRAEYVSITNQEALDAFQALAQHEGIIPALESSHALAYALKLIAQNPDKEQLLVVNLSGRGDKDIFTVDKILNGGN
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
B0BU72
Q39WF4
SYY_GEOMG
Tyrosyl-tRNA synthetase
Geobacter
MSVAEQMAIIKRGATEILLEKELEEKIEKSLSTGVPLRIKAGFDPTAPDLHLGHTVLLHKMRQFQQLGHEVCFLIGDFTGMIGDPTGKSETRKALTREDVLKNAETYKEQVFKILDPKKTRVVFNSEWLGKMTASDMIGLAAQSTVARMLERDDFGKRFANQLPISIHEFLYPLIQGYDSVALKADVELGGTDQKFNLLVGRELQRVWKQSPQSVITMPLLEGLDGVNKMSKSLGNYIGINEPADEIFGKIMSISDELMLRYYELLSDLTLAEIEKLKAAMRDGDVHPMAAKKQLAREIVARYHGAVAADNAEESFVRRFRDNQTPEEMPECILSAEEGKVLLGRLLAEAGLVKSNSEGRRAINQGGVKVNGEKVTNDMLELPGVGEYVLQFGKRRFARIVFK
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Q39WF4
Q6R8G4
PHO16_ARATH
Protein PHO1 homolog 6
Arabidopsis
MKFGKDFSSEWQQAYVDYKYLKTLVKDINRFKRKTNLHGGQISLSSTVLEIEDGITTATIQVSSTASQRYETTFLMTAEKGGEYELVFFRRLDDEFNKVEKFYREKVDEVVKEAAVLNKQMDALIAFRLKMKEESTVEMARFALHGVVSPAELAKNPSMKVHMEAIEEGGSSRAGRRSDEDDYYTDEEDHNDVFFTPANNLSKMKSSSSAFIEVLDSIKINNTKEALQSNTKSVLKVSNHTELKFSRDNLRKIEEKLICAFVEFHRKLWYLKSYSFLNVLALSKILTKYDKITSRDAAKSYMKMVDKSCLGSSDEVMKLMENVEATFIKQFTNGNRTKGMNILRPKPKRERHRLTFSTGFLGGCMFSLIVALVAIVRTRNILQDDGQKQYMNTMFPLYSLFGFIMLHMTMYAANIYFWRQYRVNYSFIFGFKQGTELGYKQVLFVGFSIGALALLCVLANLDMETDPKTKDYQALTELLPLFLLIAMFVVLVVPFNIFYRSSRFFFLTTLFHMLAAPLYKVTLPDFFLADQLCSQAQTLRSIEFYICYYGWGDFKQRKNTCKDSQVFNTFLFIVSAFPFFSRFLQCMRRMLEEKNIEQGYNGFKYIVIVVAVCLGMAYEVDDEKDRQIIWRLLGGITSAMAVVFCTYWDLVYDWGLLNRTSKNPWLRDNLLIPHKEVYVLAMILNVVLRFAWMQTVLDFKFESIHTQTVVAVVASLEIIRRGIWNFFRLENEHLNNVGKYRAFKAVSLPFNYEVDH
May transport inorganic phosphate (Pi).
Q6R8G4
Q41014
FENR2_PEA
Ferredoxin--NADP reductase, root isozyme, chloroplastic
Pisum
MSHLAVSQMAVTVPVSSDFSVRRSAFKSSNLNFRDKSWAPVFTLGMKAKNCGWRNHNVICMSVQQASVPKVTVSPLELENPSEPPLNLHKPKEPYTATIVSVERLVGPKAPGETCHIVINHDGNVPYWEGQSYGVIPPGENPKKPGSPHNVRLYSIASTRYGDNFDGKTASLCVRRAVYYDPVTGKEDPSKNGVCSNFLCDSKPGDKIKIAGPSGKIMLLPEDDPNATHIMIATGTGVAPYRGYLRRMFMESVPTFKFGGLAWLFLGVANVDSLLYDDEFTKYLKDYPDNFRYNRALSREEKNKNGGKMYVQDKIEEYSDEIFKLLDNGAHIYFCGLRGMMPGIQETLKRVAEKRGESWEEKLSQLKKNKQWHVEVY
May play a key role in regulating the relative amounts of cyclic and non-cyclic electron flow to meet the demands of the plant for ATP and reducing power. Is involved in nitrate assimilation.
Q41014
Q8W4B2
APEM9_ARATH
Protein DAYU
Arabidopsis
MEATDIWGEIERSESYLVCSMYEEAESLSSSILKRIFGNIDVLSDEASQGDHQFHDMLESAGMVLVQSLHGIGRTVEIVNELRDVFGEVAAIPVQVLLTGVCLQISNGSYLGVRDILEEFFRIWVYKDNHYILNDAGVSTKGFHAKNCLDIDEYMEVVELYTFGVLAKFSNDMGLAISWVEKAALPEERRQGILRRLHSLLSLKTASSFEENSKDSSYAVVNNKKSLGNEKNDEIDSFLKLSKQHEPWSLWSSHPLSLKVGNTQFSMSRGKVAVSLVGLIICYALKRKRAALIRIIRRQMESTRKAIVDFWKLAFSYQVNPLAAIQSIPSTTT
Involved in peroxisome biogenesis and matrix protein import . Required for pollen maturation and in vivo germination via its role in peroxisomal function, which partially involves jasmonic acid biosynthesis . Transported to peroxisomes via the interaction with PEX19-1 . Required for peroxisomal protein import by acting as an anchoring protein for the AAA ATPase complex, which consists of PEX1 and PEX6 .
Q8W4B2
Q32GQ6
RIBA_SHIDS
GTP cyclohydrolase II
Shigella
MQLKRVVEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK
Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.
Q32GQ6
A3DE48
RIMP_ACET2
Ribosome maturation factor RimP
Acetivibrio
MTRKEIEEIVTEIANPVVNKHSFELVDVEFIKEGSSWYLRIYIDKPGGITIDDCQVVSEEISDILDKEDPIPHSYFLEVSSPGLDRPLKKESDFERFKGELVEVKVFKPIEGKKIFEGELVGYKDNKIIIKKNGNELMEFERDKVALVRRVIKF
Required for maturation of 30S ribosomal subunits.
A3DE48
Q605G9
PANC_METCA
Pantoate-activating enzyme
Methylococcus
MKIVSTKTELEAVLAPWRAADDSIAFVPTMGNLHAGHLHLVDTAKTKARRVVVSIFVNPTQFGPDEDLAAYPRTPEQDIERLRAHQADLLYLPDAADVYPDDGQPATFVEVPGLSEQLCGKFRPGHFRGVATVVCKLLNRVRPDLALFGEKDFQQLTVIRKMVRDLDMAVTIMGVPTVREPSGLAMSSRNAYLSPEQKERASLIFRTLNQAAEAVRAGERDYARIEQEASATLEAGGFSVDYVSIRRQQDLAAPSADDSALVILAAAHLGRARLIDNVLISLDTTR
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q605G9
Q58030
END3_METJA
DNA-(apurinic or apyrimidinic site) lyase
Methanocaldococcus
MELIEILLKKLNKNAVVTEIAKDKDPFKVLISTIISARTKDEVTEEVSKKLFKEIKDVDDLLNIDEEKLADLIYPAGFYKNKAKNLKKLAKILKENYNGKVPDSLEELLKLPGVGRKTANLVITLAFNKDGICVDTHVHRICNRWEIVDTETPEETEFELRKKLPKKYWKVINNLLVVFGREICSSKSKCDKCFKEIKEKCPYYEKIKHFENILKKFNFRKVSKNKIPNEKGTYILKIRLKEGKKIKFGKTERFFKKGYYFYIGSAFGNSMNLKNRIERHLKDDKKMHWHIDYLLKYGKIEEIYITNERVECEVANEFIKKFDFVENFGCSDCKCKSHLFYLKP
DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
Q58030
Q18CG4
RL16_CLOD6
50S ribosomal protein L16
Clostridioides
MLMPKRVKRRRVHRGSMAGQAHKGNKVTYGEFGLVALEASWITSNQIEAARIAMTRYIKRGGKVWIKIFPHKPVTRKPAETRMGAGKGSPEYWVAVVKPGRVMFELAGVSEDKAREAMRLAAHKLPIKCKFVKKEDLEVKGGE
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q18CG4
B8FUL3
YBEY_DESHD
Endoribonuclease YbeY
Desulfitobacterium
MYLDINWEEDSIPENERGSLTGLLEQGIAKAVHLSAESEEAEVSLTLVDDARIHELNRDYRGVDRPTDVLSFALQEERSDEPDILDYEDHLLGDIIISVERARAQAIDYGHSFERELVYLAVHGTLHLLGYDHMEEEDKEEMRRQEEAVMSQIGLLR
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
B8FUL3
Q9ZM66
FTSH_HELPJ
ATP-dependent zinc metalloprotease FtsH
Helicobacter
MKPTNEPKKPFFQSPIVLAVLGGILLIFFLRSFNSDGSFSDNFLASSTKNVSYHEIKQLISNNEVENVSIGQTLIKASHKEGNNRVIYIAKRVPDLTLVPLLDEKKINYSGFSESNFFTDMLGWLMPILVILGLWMFMANRMQKNMGGGIFGMGSAKKLINAEKPNVRFNDMAGNEEAKEEVVEIVDFLKYPERYANLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAHVPFFSMGGSSFIEMFVGLGASRVRDLFETAKKQAPSIIFIDEIDAIGKSRAAGGMISGNDEREQTLNQLLAEMDGFGSENAPVIVLAATNRPEILDPALMRPGRFDRQVLVDKPDFNGRVEILKVHIKGVKLANDVNLQEVAKLTAGLAGADLANIINEAALLAGRNNQKEVKQQHLKEAVERGIAGLEKKSRRISPKEKKIVAYHESGHAVISEMTKGSTRVNKVSIIPRGMAALGYTLNTPEENKYLMQKHELIAEIDVLLGGRAAEEVFLEEISTGASNDLERATDIIKGMVSYYGMSSVSGLMVLEKQRNAFLGGGYGSSREFSEKTAEEMDLFIKNLLEERYQHVKQTLSDYREAIEIMVKELFDKEVITGERVREIISEYEAANNLESRLIPLEEQAS
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Q9ZM66
Q82WB9
MDH_NITEU
Malate dehydrogenase
Nitrosomonas
MSSPIRIAVTGAAGQISYSLLFRIAAGDMLGSSQPVILQLLDIPESGKVLDGVLMELQDCAFPLLTDIIVTHDPMIAFDQADIAILVGARPRGKGMERKDLLQTNGEIFREQGRALNQVVKRDAKILVVGNPANTNTLITMKNAPDLSPENFSGMLRLDHNRALSQVAMKLNQPVSHIRKMIVWGNHSSTQFPDLSHAEIDHQKVIDLIKDQTWVENSFIPTVQNRGAVVIEARGLSSAASAANAIIDHMRDWIFGTRDDDWITMGILSDGSYKIPKGVIYGFPVVCKNGGRKIVQGLEISPFSRTRLDIAYDELTQELDSIKHLLL
Catalyzes the reversible oxidation of malate to oxaloacetate.
Q82WB9
Q8XZJ6
DEF2_RALSO
Polypeptide deformylase 2
Ralstonia
MIRPILKMGDSRLLRVAKPVQRFQTPELTALIEDMFDTMDAARGAGLAAPQIGVDLQVVIFGFDRNDRYPDAPAVPKTVLINPTIEPLSDAMEDGWEGCLSVPGLRGVVPRYTRLRYTGYDQHGHAIDRIAEGFHARVVQHECDHLQGILYPMRVQDFTRFGFTEILFPELPAHHND
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Q8XZJ6
A9ITN0
NADD_BORPD
Nicotinate mononucleotide adenylyltransferase
Bordetella
MKRIGLLGGSFDPVHLAHLALARAAAAELRLDSVQLIPAANPWQRAPLRASAGHRLRMIELAIDGEPQLAVNPVELERGGPTYTIDTVRALPADAHYVWLLGTDQLANFCTWRQWQAIAGHVDLAVAARPGAPLAAPAELASWLAAHRRRLIRLPFSPMAISASDIRGRLARGASTAGLLPATVARYIARHGLYR
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
A9ITN0
P42472
EFTU_CHLAU
Elongation factor Tu
Chloroflexus
HVDHGKTTLTAAITKVMSLKGAAQFMAYDQIDNAPEERARGITIAIRHVEYQTDKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSAPDGPMPQTREHILLARQVQVPAIVVFLNKVDMMDDPELLELVELELRELLSKYGFPGDEIPIVRGTARNALESPSKDINAPEYKCILELMNAVDEYIPTPQRAVDQPFLMPIEDVFGIKGRGTVVTGRIERGKVKVGDTVEIVGMTNDAPRRTVVTGVEMFQKTLDEGIAGDNVGCLLRGIERTDVERGQVLCAPGSIKPHKKFEAQVYVLKKEEGGRHTPFFSGYRPQFYIRTTDVTGAIGLPAGMEMVMPGDNVVMTIELIVPVAIEEGLRFAIREGGRTVGAGVVTKILD
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
P42472
P50132
GPR4_PIG
G-protein coupled receptor 4
Sus
MGNGTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVRQRNELGVYLMNLSIADLLYICTLPLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSVVWATELGANSVPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRGSVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAVYLGHPWDCGFEERVFSAYHSSLAFTSLNCVADPILYCLVNEGARSDVAKALHNLLRFLTSDKPQEMASASLTLDTPLTSKRNSMARAVAAGWVASPPSQGDQVQLKMLPPPAP
Proton-sensing G-protein coupled receptor couples to multiple intracellular signaling pathways, including GNAS/cAMP, GNAQ/phospholipase C (PLC), and GNA13/Rho pathways. Acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelial cells through the GNA12/GNA13/Rho GTPase signaling pathway. In the brain may mediate central respiratory sensitivity to CO(2)/H(+).
P50132
P03052
KORA2_ECOLX
Regulatory protein KorA
Escherichia
MKKRLTESQFQEAIQGLEVGQQTIEIARGVLVDGKPQATFATSLGLTRGAVSQAVHRVWAAFEDKNLPEGYARVTAVLPEHQAYIVRKWEADAKKKQETKR
In conjunction with KorB, inhibits the transcription of kilA, trfA and korAB operons. In conjunction with KorC is responsible for the negative control of kilC and kilE operons.
P03052
B1KI55
LEPA_SHEWM
Ribosomal back-translocase LepA
Shewanella
MKHIRNFSIIAHIDHGKSTLSDRLIQECGGLSDREMAAQVLDSMDIERERGITIKAQSVTLDYKALDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTALEMDMDVVPVLNKIDLPQADPERVADEIEDIVGIEAADAVRCSAKTGIGIKDVLEVIVAQIPPPEGDTEGPLQALIIDSWFDSYLGVVSLVRIKNGILKKGDKFKVMSTGQTYNADRVGIFTPKQTDTAELKTGEVGFVIAGIKEIHGAPVGDTLTHAKHGAEKPLGGFKKVKPQVYAGVFPISTDDYESFRDALNKLSLNDASLFFEPETSSALGFGFRIGFLGLLHMEIIQERLEREYNLDLITTAPTVVYEIVKTSGDTIYVDNPSDLPAINNIAEMREPIVETNILVPKDYLGNVITLCVEKRGVQKNMVYHGNQVAITYELPMAEVVMDFFDRLKSTSRGYASLEYNFVRFEPADMVRLDILINGDRVDALAMIIHKGLIRTKGLALVNKMKELIPRQMFDIAVQAAVGSQIIARSSIKAMRKDVTAKCYGGDVSRKKKLLNKQKEGKKRMKSVGNVEVPQEAFLAVLKLND
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
B1KI55
P11017
GBB2_BOVIN
Transducin beta chain 2
Bos
MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
P11017
A8EST5
RUVA_ALIB4
Holliday junction ATP-dependent DNA helicase RuvA
Aliarcobacter
MIVGLIGKIIKKEPTQLNVNVNGVIYEVFVSLNCSSKIVSDDVKLEITHIIREDAQSLYGFLDSNEKKLFDTVIKINGVGPKVALAICSTFTPTSFAQIVSSNDVSMLKRVPGIGPKGASRILVELSGFIIDSNDETSGSSSALEAALALESLGFKKDLVSSVLKTCVNSNTSDLVKEALKKLQK
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
A8EST5
Q04J70
SECA_STRP2
Protein translocase subunit SecA
Streptococcus
MANILKTIIENDKGEIRRLEKMADKVFKYEDQMAALTDDQLKAKTVEFKERYQNGESLDSLLYEAFAVVREGAKRVLGLFPYKVQVMGGIVLHHGDVPEMRTGEGKTLTATMPVYLNALSGKGVHVVTVNEYLSERDATEMGELYSWLGLSVGINLATKSPMEKKEAYECDITYSTNSEIGFDYLRDNMVVRAENMVQRPLNYALVDEVDSILIDEARTPLIVSGANAVETSQLYHMADHYVKSLNKDDYIIDVQSKTIGLSDSGIDRAESYFKLENLYDIENVALTHFIDNALRANYIMLLDIDYVVSEEQEILIVDQFTGRTMEGRRYSDGLHQAIEAKEGVPIQDETKTSASITYQNLFRMYKKLSGMTGTGKTEEEEFREIYNIRVIPIPTNRPVQRIDHSDLLYASIESKFKAVVEDVKARYQKGQPVLVGTVAVETSDYISKKLVAAGVPHEVLNAKNHYREAQIIMNAGQRGAVTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMKRFGSERLKGIFERLNMSEEAIESRMLTRQVEAAQKRVEGNNYDTRKQVLQYDDVMREQREIIYAQRYDVITADRDLAPEIQAMIKRTIERVVDGHARAKQDEKLEAILNFAKYNLLPEDSITMEDLSGLSDKAIKEELFQRALKVYDSQVSKLRDEEAVKEFQKVLILRVVDNKWTDHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFRMFNDMIGSIEFDVTRLMMKAQIHEQERPQAERHISTTATRNIAAHQASMPEDLDLNQIGRNELCPCGSGKKFKNCHGKRQ
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Q04J70
Q9ZKR8
QUED_HELPJ
Queuosine biosynthesis protein QueD
Helicobacter
MVIRRLYKFCASHVVRNCSSLKCAQNIHGHNYEVEVFIETNRLDNANMALDFGLMQQEMQTFIDSFDHAHHFWDKESPEFQRFIENHCVRYVKCSFNLSAESYALMFLYYLTKILQKSVFSNNEGELKVSSVRVHETKNGYAESFLKDLENPHFKSLVHDHCVSFSQGIQSLWHDKDFFHKIISDEKQCFFHAKPLHQIP
Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.
Q9ZKR8
Q85FK2
PSAJ_ADICA
PSI-J
Adiantum
MQHVKIYLSTAPVVATIWFGLLAGLLIEINRFFPDALLFPFP
May help in the organization of the PsaE and PsaF subunits.
Q85FK2
Q31BV1
DCUP_PROM9
Uroporphyrinogen decarboxylase
Prochlorococcus
MGENLPLLLSAALGKKVTRPPVWMMRQAGRYMKIYRDLRERYPSFRERSENPELSYEISMQPFHAFKPDGVILFSDILTPLPGMGINFEIIESKGPIIEDPIRTLSQIESLKELNPSESLSFVGQVLSSLKKDVNNEATVLGFVGAPWTLAAYVVEGKSSKNYSLIKSMAFKEPDLLHKLLDHFAKSIGEYLKFQIKSGAQVVQIFDSWAGQLSPQDYDIFAGPYQKKVVDIVKEEYPDTPVILYISGSAGVIERMAKTGVDIISLDWTVDIEEACKRIPDEIGIQGNVDPGILFGNKESIKERIDDTFNKIKDRKYILNLGHGILPGTPEENAQTFFEHGKKLTY
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Q31BV1
Q0HGL4
GRPE_SHESM
HSP-70 cofactor
Shewanella
MSNESIKAEQDLIQEGVESEVSTEEASLIDELTQANFRIEELEQLLADALAKVEEQKDSVIRAAAEVDNIRRRAAMDVEKANKFALEKFANELLPVLDNMERALQGTNPQDETTKAIYEGVELTQKSLLTAVAKFGVKPIDPQGQAFNPDQHQAIGMQPSAEFPANTVMLVMQKGYELNSRLLRPAMVMVSQGGPSQEINIEA
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Q0HGL4
Q8ZVM8
RRP4_PYRAE
Exosome complex component Rrp4
Pyrobaculum
MYYVTPRQLVFPGDVIATADSKVEGPVYLDNGKYRSLVVGLVEFREDVVVVVPLEGTYKPKKGDLVIGYVTDVLATGWEVDVRSFMPAYLPVGEALHRHVDLETTPLTTFLNIGDVVVAKVKDVDLTDEYPIILTLKDEKVGKVESGTVVEITPVKVPRVIGKRGSMLNTLMELGCDIVVGQNGRIWVKCKDPRDEVFLASLIRKIEAESHVMGLTDRIRAEIENYKTSKQQGTV
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.
Q8ZVM8
B2X205
YCF12_OEDCA
Photosystem II reaction center protein Ycf12
Oedogonium
MNIDILSQLIAIAVTLFLGPVVVILIASRNGNL
A core subunit of photosystem II (PSII).
B2X205
A7Z268
GATB_BACVZ
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Bacillus amyloliquefaciens group
MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGYPGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGENGWIEIEVGGKTKKIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRTPEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEKFGTKTELKNLNSFAFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDLVELYIDDEWKERVRATIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVNKGAEAKQASNWLMGEVSAYLNAEQKELEDVALTPEGLAGMIKLIEKGTISSKIAKKVFKELIEKGGDAEKIVKEKGLVQISDESVLLKLVTDALDSNPQSIEDFKNGKDRAIGFLVGQIMKASKGQANPPMVNKILLEEIKKR
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
A7Z268
Q92SK4
IXTPA_RHIME
Nucleoside-triphosphate pyrophosphatase
Sinorhizobium
MRRLIDKTLVVASHNAGKIREIRDLIGPLGFEAKSAADLNFVEPDETGTTFEENATIKALASAKASGLPALSDDSGLAVDALGGAPGVYTANWAEREDGSRDFQMAMEKVEEALRAKGAVKPESRTARFVSVLCLAWPDGHVELFRGEVEGYVVWPPRGTSGFGYDPVFQPKGYDTTFGEMSAEEKHGWKPGDSEALSHRARAFKLFAETCLGA
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Q92SK4
Q96P50
ACAP3_HUMAN
Centaurin-beta-5
Homo
MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKETKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLRPHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTELQFRRCIQEFISLHLEES
GTPase-activating protein for the ADP ribosylation factor family.
Q96P50
A1ATU9
SYA_PELPD
Alanyl-tRNA synthetase
Pelobacter
MTGSEIRRRFLTFFAERGHTIVPSSGIIPKNDPTLMFANAGMNQFKDCFLGMEKRDYTRACSSQKCVRAGGKHNDLENVGRTARHHTFFEMLGNFSFGDYFKKEAIAFAWEFLTRDLKLDKNRLYVSVYTDDQEAADIWHQQEGVPLERIFRFGEKDNFWSMGDTGPCGPCSEIFYDQGEAAGCGSPDCTVGCDCDRYMEIWNNVFMQFDRSTDGVLTPLPKPSVDTGMGLERISAVMQGVTSNYDTDLIQGIIRHVERLSGKTYGKDERDDVSMRVIADHARAVTFLICDGALPSNEGRGYVLRRIMRRAARHAKMLGLADPMLCHMVDAVRDMMGAAYPELVEREEYIKKVILAEEQRFAETLDRGLAMLNDEVARMRAAGSTVIPGDVLFRLYDTYGFPIDLTADIVESEGFTIDEAGFEQCMERQREQAREHWKGSGAEGIGRVYKELYSRGIRGEFVGYDGLSALSPVLAIIRDGVEVESATAGETIELVTESTPFYGESGGQKGDCGSISTGNSHLEVSGASRPYSDLIVHHATVREGIIRKGDGADLRVSRPERSATARNHTATHLLQAALRRVLGEHVKQAGSLVSPDRLRFDFIHFTAMTTEEIRRVETLVNGFVMDNQPVVITQMDMASAIEAGATALFDEKYGDNVRVVRAGEVSMELCGGTHVRATGEIGLFKIITETGIAAGVRRIEAQTGGGALSFVRQMEDEQRALAGLLKAEGGNLPERLEKLLARQREMQREIESLQGKLNAAASGDLLSGVEEVGGIKLLAAEVRVEDVKALRDLSDTLKERIGQGVIVLGAAIGGKANLLVAVTRELSGTVKAGDLVKKLAPLVGGSGGGKPELAQAGGSRPENLAEALAAARQVLAEQ
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
A1ATU9
B2VGQ6
RAPA_ERWT9
ATP-dependent helicase HepA
Erwinia
MPFTLGQRWISDTESELGLGTVVAVDTRMVTLLFPATGENRLYARNDSPITRVVFNPGDTITSHEGWQLDVDEITTANGVVSYIGTRLDTSETGVVLREVMLDSKLVFGKPQDRLFAGQLDRMDRFALRFRARKYQSEQYRLATSGLRGMRTSLIPHQLHIAHDVGRRHAPRVLLADEVGLGKTIEAGMIIHQQLQAGRAERVLIVVPETLQHQWLVEMLRRFNLRFALFDDDRYAQAQLDSDNPFDTEQMIICSLDFVRRNKQRLEKLADAEWDLMVVDEAHHLVWSEDAPSREYQVIEQLAEQVPGILLLTATPEQLGMESHFARLRLLDPDRFHDFAQFVEEQKHFSPIADAVTLLLADQKIGNDELNLLNDLMGEQDIEPLLQTANSDREGKLAARQELISMLMDRHGTSRVLFRNTRNGVKGFPKRELHQIRLPLPTQYQTAIKVSGIMSARKTADERAQDMLYPEQIYQEFEGDSGTWWNFDPRVEWLMGYLTSNRDKKVLVICAKAATALQLEQVLREREGIRAAVFHEGLSIIERDRAAAWFASEEDGAQVLLCSEIGSEGRNFQFASQMVMFDLPFNPDLLEQRIGRLDRIGQVHDIQIHVPYLEKTAQAVLVQWYHEGLDAFEHTCPTGRAVYDSVYTQLIAYLAAPENSEGLEAFIQHCRKQHDTLKAQLEQGRDRLLELNSNGGEKGQALADMIAEQDNNIELVNFALNLFDIVGINQEDRSDNLIVLTPGDHMLVPDFPGLPEDGCTITFDRNQALSREDAQYVSWEHPIIRNGLDLILSGDTGSCAISLLKNKALPVGTLLVELIYVVEAQAPKHLQLTRFLPPTPIRMMVDRKGNNLAAKVEFESFNRQLNAVNRHTGSKLVNAVQSDVHEIITLSEDQAAAEARKVIDAARQEADEKLSAELSRLQALSAVNPNIRQDEIDALESNRQQVLSNLDEAGWRLDALRLIVVTHQ
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.
B2VGQ6
B8F3L6
SECA_GLAP5
Protein translocase subunit SecA
Glaesserella
MFTKLMTAIFGSSNDRTLRRLNKRVAQINRLEAEFEKLTDEQLQAKTAEFKQRLAEGATLDSLLHEAFATVREASKRVLGMRHFDVQLIGGMVLTERNIAEMRTGEGKTLTATLPCYLNALTGKGVHVVTVNDYLARRDAETNRPLFEFLGMTVAVNIPGLPSDVKRQAYLADITYATNSELGFDYLRDNLAHSKEERFQRPLHYALVDEVDSILIDEARTPLIISGPAEDATQIYQAIDKVIPHLIAQDKEDTEEYTGDGDFTLDLKSKQAHLTERGQVKVENILTKMGLMHEGESLYHPARISLLHHVYAALRAHKLFEVNVDYIVKDGEIVIIDEHTGRTMAGRRWSDGLHQAIEAKEGVNIQGENQTVASITYQNYFRLYEKLAGMTGTADTEAFEFQQIYGLDTVVIPTNRPMIRDDKTDLMFKSEPEKFQAVIKDIQDCIARKQPVLVGTISIEKSEALSEALKQAGIPHKVLNAKFHAQEAEIVADAGYPGAVTIATNMAGRGTDIVLGGNWKAEIAKLENPTQEQIDEIKAKWQERHDIVMQAGGLHIIGTERHESRRIDNQLRGRSGRQGDPGSSRFYLSLDDALMRIYLNEGKLNMMRKAFTEEGEAMESKLLTKVIASAQAKVEAYNFDGRKQLLQYDDVANEQRKAIYEQRNYLLETDDISAMINTVREDVFNAVIDQYIPPQSIEEMWDVPALENRLKQEFGMELPIVKWLEAEDDLHEETLRERIINIAKEQYQAKEAMVGAEVMRSFEKGVMLQNLDELWKEHLSAMDYLRKGIHLRGYAQKDPKQEYKKESFAMFTDMLDHLKSNVISVLSRIQVRSQEEVEQAERERQAHAEQESSHYHAEGEGQDFSDLHIGRNEPCPCGSGKKYKHCHGSKAKYS
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
B8F3L6
Q6HBC2
UVRB_BACHK
Excinuclease ABC subunit B
Bacillus cereus group
MERQFEIVSAYSPQGDQPVAIEKLVEGINSGKKKQVLLGATGTGKTFTISNVIKEVQKPTLVMAHNKTLAGQLYSELKDFFPNNAVEYFVSYYDYYQPEAYVPQTDTFIEKDAQINDEIDKLRHSATSALFERDDVIIVASVSCIYGLGSPEEYRELVVSLRVGMEKDRNQLLRELVDVQYGRNDIDFKRGTFRVRGDVVEIFPASLDEHCIRIEFFGDEIDRIREVNALTGEVLAERDHVAIFPASHFVTREEKMKVAIENIEKELEERLKELNDNGKLLEAQRIEQRTRYDLEMMREMGFCSGIENYSRHLTLRPAGATPYTLLDYFPEDFLIVMDESHVSVPQVRAMYNGDQARKQVLVDHGFRLPSALDNRPLTFDEFEEKTNQVIYVSATPGPYELEQSPEVIEQIIRPTGLLDPPIDIRPIEGQIDDLLGEIQDRIAKNERVLITTLTKKMSEDLTDYLKDVGIKVNYLHSEVKTLERIEIIRDLRLGKFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNENGRVIMYADRITRSMGIAIEETKRRRSIQEAYNEEHGITPKTIQKGVRDVIRATTAAEEPETYEATPAKKMTKKEREKTIAKMEAEMKEAAKALDFERAAELRDLLLELKAEG
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.
Q6HBC2
A8YXI6
PTH_LACH4
Peptidyl-tRNA hydrolase
Lactobacillus
MKIIAGLGNPGQKYDKTKHNTGFMTLDHYLNEKGLSLDKDKFEGHWTKQKINGEDVILLEPQTYMNESGRSVSQIANFFKVAPEDVLIIQDDMDMPIGKIRIRANGKSGGHNGIKSIIRDLGTEKFNRLKIGIRHPKNTTVVSWVLTPFNDEQQKLMDDAFDTSVKIIDDFIAGRDSQYLMNKYN
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
A8YXI6
P0CV49
RL120_PLAVT
Secreted RxLR effector protein 120
Plasmopara
MRGAYYVITALLVVASSQTSADSGHRLHVYDHDVVAAENAAAKTLPQQSLRGSRDVPDDLAHEERAIISELVEEGAKLIPRAAENVEEMPRVTEAVGKRPRVAEKDALEKASGADEASKKPRNTATDDAFQGMSTEWELELPFKEWNTEIEPMREMPEPKWSWEKRKLVHEAFVKLCAEDLNPTVYETARLWSLFDGKAKSRPATFHRQVLIQLAKENVRRDVLIMKSVESEWDRWNEVSILSRVDVLNMLLNVHFQRWKRMYNAFGEQRSKLIAL
Secreted effector that completely suppresses the host cell death induced by cell death-inducing proteins.
P0CV49
B2JI54
RL24_PARP8
50S ribosomal protein L24
Paraburkholderia
MNKIRKGDEVIVITGKDKGKRGVVLAVGENRVTVEGLNIAKKHVKPNPMKGTTGGVEAKAMPLNISNVALVDANGKPSRVGIKVEGDKKVRFLKTTGAVLSA
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
B2JI54
P41621
RBL_PINTH
Ribulose bisphosphate carboxylase large chain
Pinus subgen. Pinus
MSPKTETKASVGFKAGVKDYRLTYYTPEYQTKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYDIEPVPGEETQFIAYVAYPLDLFEEGSVTNLFTSIVGNVFGFKALRALRLEDLRIPPSYSKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFVFCAEALNKAQAETGEIKGHYLNATAGTCEEMMKRAIFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQRNHGMHFRVLAKALRMSGGDHIHAGTVVGKLEGERDVTLGFVDLLRDDFIEKDRSRGIYFTQDWVSMPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLAREGNEVIREACKWSPELAAACEIWKEIKFEFDVIDRL
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
P41621
O94418
MUG87_SCHPO
Meiotically up-regulated gene 87 protein
Schizosaccharomyces
MTVASDDSPKEARGIPFLDQKSRKLANELLEPCLPFIQFNLGEIEQRAKHYLNTVPTSKDGNTKAHYLLAGSGINAEQTWKKIESLSLQVRPPTTLELSFTDVDMFLKYHREKNVLNSLEALVQNTQIAFDQYLEEEWRSKAAKSRPSFDNILLENKKRVSFYPFSVQRSQKFASTLKMCLEEEALHGFQSKLVSSFCEVAREFAHDTKSLLLYESWKLLSSVILDKDSVTVFGNKGIISKAFDIETEDGSVNSRFYQRISDCSRKFLEAQFFEVLNKEIAKTPQAALVGGVPSIRNKIRAYLNIRLLRNGVWINPDLEIIQDVPIWAFIFYLLRCGFLKEAVDFTEENRDLFEKVAEKFPFYINAYAKAPNGILPRQLRSQLFSEFNQTIRLQESSDPYKYAVYKIIGRCDLSKTSCPSICSVTEDYIWFQLILSREFTEKSVSAHEFFSLEDVQHILLSYGSDYFTNNGSNPVMYFFLLMLCGLYERAINFLYPYFPTDAVHFAITCAYYGLLRTAPSSSVVSNEPGKIQSMLVETKSGKPSLEFDRLLIDYTQTCQELSPVMSACYLIPMCKIDKYISMCHKSLCSLVLSTRDYVNLLGDIRGDGERTPSFLENHRSLIGLSSVKEYLSKITLTAAKQADDQGLLSDAILLYHLAEDYDAAVTVINRRLGSALLRFLDQFVFPDKLISLTKSMMDVYNRNPSLYAKVDYKNRETTNLLLLTVEAFNAYTNKDYEQALSSLQQLEILPLDPLDSDCETFVVRKLAKEFRFLNENLLQNVPGIVLIAMNSLKELYAKQKSSSFGNDAISVDKLRLYRQKARRIVMYSFLIEYRMPSQILEQLNRCEIEMT
Has a role in meiosis.
O94418
Q873B7
SPC25_NEUCR
Kinetochore protein 4
Neurospora
MSRKSVMSSTFEPSLSTSRQPLGPSLADTLPSINFGFDELRDRMAKFTAKFDAFIEQGRKRVLEERNQFRMNVAELQEDQRMKKKDIEILQLKTNTYQQTMAKEAAETREMQAAIASLTEQRDKQAAMRDALKEQIAATQREIDARLAAQRAHAAQLEAQARYNVPELDFWVTNLCMRIEGAGAEDRLKFVYTHIDERNWEREAWFELSMSGRDYDVRHCRPKLEREKVEKVLDRVNETRELVVLLKGMRELFVEAMKS
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.
Q873B7
Q9FMB0
GL19_ARATH
Putative germin-like protein subfamily 1 member 9
Arabidopsis
MKSFSFLAVLSILAITLSLSKASDPSSLQDFCVGVNTPADGVFVNGKFCKDPKLVTVEDFFFTGLHEARPPNPKTGSNVTAVNVNNLPGLNTLGISLVRIDYGVYGQNPPHTHPRASEVLYVAVGTLFVGFVTSNPENRLFSKTLYEGDVFVFPQGLIHFQVNVGKYPAVAFAGLSSQNPGVITIADTVFGSNPQIDPSFLASAFQVDPKIVMDLQTKFIKP
May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.
Q9FMB0
A0KHU1
RUVC_AERHH
Holliday junction resolvase RuvC
Aeromonas
MSIILGIDPGSRITGYGVIRIVAGKAEYLGSGCIRTDLGELPSRLKQVYDGVSEIITQFKPDEFAIERVFMARNADSALKLGQARGSAIVAAVNALLPVSEYSATQIKQAVVGTGGAAKEQVQHMVTHLLKLSATPQADAADALGVALCHFHTRQILIKMAGRSTGSVRGRYR
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
A0KHU1
O09108
LSHB_MOUSE
Luteinizing hormone subunit beta
Mus
MERLQGLLLWLLLSPSVVWASRGPLRPLCRPVNATLAAENEFCPVCITFTTSICAGYCPSMVRVLPAALPPVPQPVCTYRELAFASVRLPGCPPGVDPIVSFPVALSCRCGPCRLSSSDCGGPRTQPMACDLPHLPGLLLL
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.
O09108
Q749X2
QUEA_GEOSL
Queuosine biosynthesis protein QueA
Geobacter
MLVTEFDYHLPPELIAQEPLVQRDATRLMTVERDGGGIGEIPFRGIVDLFRPGDLLVINDTRVIPARLLGRKESGGKTEIFLVRRRPGDHETWHCLIRSSKPPRPGVTVLLPEGVRAVVREPGDGETWLVSFTPGEGFQEWLDRNGAMPLPPYIRREADAADRDRYQTVFARNRGAVAAPTAGLHMTAGLLDEIAGRGVRVAPVTLHVGLGTFMPIRVERLEDHRMHRERYHIPPATADAINGCRREGGRVIALGTTVCRTLEQAAAADGTIAAGEGEADIFIYPGYRFKAVDALITNFHLPKSTLLMLVSAFAGRDLLFRAYGEAVARRFRFFSYGDAMFIF
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Q749X2
A6X0C2
RS19_BRUA4
30S ribosomal protein S19
Brucella
MARSVWKGPFVDGYLLTKAEKVREGGRNEVIKMWSRRSTILPQFVGLTFGVYNGNKHVPVSISEEMVGHKFGEFAPTRTYYGHGADKKSKRK
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
A6X0C2
A1KUD6
RLMN_NEIMF
tRNA m2A37 methyltransferase
Neisseria
MKTNLLNYDLQGLTRHFADMGEKPFRAKQVMRWMHQSGAQNFNEMTDLAKSLRHKLNEQAGIEIPKLMMSQKSSDGTRKWLLDVGTGNGVETVFIPESDRGTLCISSQVGCALECTFCSTGRQGFNRNLTAAEIIGQLWWANKAMGVTPKNERVISNVVMMGMGEPMANFDNVVTALSIMLDDHGYGLSRRRVTVSTSGMVPQMDRLRDVMPVALAVSLHASNDEVRNQIVPLNKKYPLKELMAACQRYLVKAPRDFITFEYVMLDGINDKAQHARELIELVKDVPCKFNLIPFNPFPNSGYERSSNENIRVFRDILQQAGFVVTVRKTRGDDIDAACGQLAGQVQDKTRRQQKWQQILIGQQG
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
A1KUD6
Q7W575
TPIS_BORPA
Triose-phosphate isomerase
Bordetella
MTTAENRARLVLGNWKMHGNLAENAALLAELRAADAAAHCEMGVCVPFPYLAQTAAALQGSAIGWGAQDVSAHAKGAYTGEVAAPMLAEFGCRWVLVGHSERRTLHAESDQLVADKARAALEAGLTPVVCVGESLQEREGGNTLGVIERQLEPVLALGRDALVRMVLAYEPVWAIGTGRTASPEQAQEVHSAIRVALDGLQASQVRVLYGGSVKGANAASLFAMPDIDGGLVGGASLVAEEFLRIAAA
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q7W575
Q97N13
DCDB_CLOAB
DCD-DUT
Clostridium
MILSGKQIKDSLGKDIVIEPFNEKQINPNSYNLKLHNELLVYDEEVLDMKKPNKTKKLIIPEEGIVLEPRKLYLGRTLEYTETDKYVPMLEGRSSIGRLGVFIHVTAGFGDVGFKGYWTLEIFCVEPIRIYSGVEICQIYYHDVGGDYEKYSSGKYQNNKGIQPSLLYKDFIN
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
Q97N13
Q17078
PBP2_ANTPE
APR-2
Antheraea
MIRKVLLSVLLAVLMTINLGQASPEVMKNLCMNYGKAMDQCKQELNLPDSVIADLYNFWKDDYVMTDRLAGCAINCLSTKLDIVDPDGNLHHGNAKEFAMKHGADDGMAHELVDIIHGCEKSSPPNDDKCIKTMDIAMCFKKEIHKLNWVPNMDLVVGEVLAEV
This major soluble protein in olfactory sensilla of male moths might serve to solubilize the extremely hydrophobic pheromone molecules and to transport pheromone through the aqueous lymph to receptors located on olfactory cilia.
Q17078
B7KAE8
PLAS_GLOC7
Plastocyanin
Gloeothece citriformis
MLKKLGVLLSAIVLVIASFFVTVTPALAETYTVKMGSDQGLLKFDPPQLTIKAGDTVKWVNNKLAPHNAVFDNSKVPDSVSATKISHKALVFSPGESFTTTFDEPGTYTYYCEPHRGAGMVGTITVE
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
B7KAE8
B1XHZ7
ISPG_SYNP2
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
unclassified Synechococcus
MQAVERPVQTTDSLVDTTIHRRKTRAVKVGNVTIGSDYPVVVQSMINEDTLDIEGSVAAIRRLHEIGCEIVRVTVPSMAHARSLAQIKAKLAETYQAVPIVADVHHNGMKIALEVAKHVDKVRINPGLYVFEQASGDRTGYTEAEFAAIGEKIRETLEPLVVSLRDQGKAMRIGVNHGSLAERMLFTYGDTPEGMVESALEFIRICQSLDFHNLIISMKASRVPVMLAAYRLMAKRMDELGMDYPLHLGVTEAGDGEYGRIKSTAGIGTLLAEGIGDTIRVSLTEAPEKEIPVCYSILQALGLRKTMVEYVACPSCGRTLFNLEEVLHKVREATNHLTGLDIAVMGCIVNGPGEMADADYGYVGKTPGVISLYRGREEIRKVPEAQGVEELINLIKADGRWVDPPQ
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
B1XHZ7
B4F111
MURG_PROMH
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Proteus
MSERKRRLMVMAGGTGGHVFPGLAVAHYLQSQGWDIRWLGTADRMEAQLVPKHGIEIEYIRISGLRGKGVKALIAAPIRIIKAIFQARRIMKRYQPDAVLGMGGYVSGPGGVAAWSCGIPVVLHEQNGIAGLTNRWLSKIAKRVLQAFPGAFANAPVVGNPVRDDVLALEAPAERLKGREGAVRVLVIGGSQGARILNHTMPVVAGLLGERVTIWHQAGKGSESDTKLRYQNELSKNSVKSEYKVTEFIDDIAQAYQWADVVVCRSGALTVSEIAAAGLPAIFVPFQHKDRQQYWNALPLENAGAARIIEQNDLTPEAIADTLENWDRHQLMLMAEKAQSVAITDATERVANVIIEVAKK
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
B4F111
A6X1H1
COBS_BRUA4
Cobalamin-5'-phosphate synthase
Brucella
MQRNSLIGDTIRSLGFLSRLPLPQRWFEDGDDSLPRNARAFPLAGAVLGLLAGAVLFMAYKVNLPPLACAMLAIGALAAMTGALHEDGLGDTADGFFGASSPDRRLDIMKDSRIGTFAALTLIVFVGLKAALLMTIIDRAGAGYAALALVGCEAASRSGMLAFWHALPSARPGGLSDSVGQPQWETVVCGFGIGLAFLVFTLIPAGGFLSLINALVLATGLLFGFARLCIAKIGGQTGDTLGAAQQIGSVAVLAGLVMAL
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
A6X1H1
B2HZM2
RL3_ACIBC
50S ribosomal protein L3
Acinetobacter calcoaceticus/baumannii complex
MHMAIGLVGRKCGMTRIFTDAGVSVPVTVIEVDPNRITQIKTLETDGYQAVQVTTGERRESRVTNAQKGHFAKAGVAAGRLVKEFRVTEAELEGREVGGTIGVDLFTVGQIVDVTGQSKGKGFQGGVKRWNFRTQDATHGNSVSHRVLGSTGQNQTPGRVFKGKKMAGHLGDERVTVQGLEIVSVDTERSVLVVKGAIPGATGGDVIVRPTIKA
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
B2HZM2
Q63R14
PHNN_BURPS
Ribose 1,5-bisphosphokinase
pseudomallei group
MSAERLVYVMGPSGAGKDSLLAYARKHVREPRIAFAHRYITRKSDGHENHVELTRDEFAARAQLGFFALEWSSHGFRYGVGVEIDAWLAAGSVVVVSGSRAHLPAALERYPQMCVVHIDAAPHVLAERLATRGRETADEIRARLARSVRWAVPDGVALTAIDNSGTLDDAGRVLVALLEGLARS
Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).
Q63R14