accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q31Z75
GLPB_SHIBS
Anaerobic glycerol-3-phosphate dehydrogenase subunit B
Shigella
MRFDTVIMGGGLAGLLCGLQLQKHGLRCAIVTRGQSALHFSSGSLDLLSHLPDGQPVADIHSGLESLRQQAPAHPYSLLGPQRVLDLACQAQALIAESGAQLQGSVELAHQRITPLGTLRSTWLSSPEVPVWPLPAKKICVVGISGLMDFQAHLAAASLHELDLSVETAEIELPELDVLRNNATEFRAVNIARFLDNEENWPLLLDALIPVANTCEMILMPACFGLADDKLWRWLNEKLLCSLMLLPTLPPSVLGIRLQNQLQRQFVRQGGVWMPGDEVKKVTCKNGVVNEIWTRNHADIPLRPHFAVLASGSFFSGGLVAERNGIREPILGLDVLQTATRGEWYKGDFFAPQPWQQFGVTTDETLRPSQAGQTIENLFAIGSVLGGFDPIAQGCGGGVCAVSALHAAQQIAQRAGGQQ
Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.
Q31Z75
Q0VS73
GATB_ALCBS
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B
Alcanivorax
MSWEIVIGLEVHVQLNTASKLFSGSKLSTGAEPNTQASLVDLGLPGTLPVVNREAVRKAALFGLAIDADICRHSVFERKNYFYPDLPKGYQTTQLAEPIVGAGTVEIQLDNGEKKSIRIHHAHLEEDAGKSLHEDFHGMTGIDLNRAGTPLIEIVSEPDMANAEEAVAFARKLHAIVTSIGICDGDMSQGNMRFDVNISVRKPGEPLGTRTETKNLNSFRFMEKAIALEVERQIDVLEDGGEIVQETRLYNGDTHTARSMRSKEDANDYRYFPCPDLLPVAITDADIEELKAAMPELPDSRKARFTNDYQLSEYDADLLSGSIATAAFFEAAAKSGGDAKLAANWVMGELAAKLNAEEKSITDSPVSAEQLGQLIARLKDGTISSKIAKQVFEACWAGEGNPDEIIEAKGLKQMSDTGELEKIVDDIIANNAAQADDYRNSDDAKKKKKIGFFVGQAMKATQGKANPQQLNKLLQEKLQ
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).
Q0VS73
Q79FL8
PG30_MYCTU
PE-PGRS family protein PE_PGRS30
Mycobacterium tuberculosis complex
MSFLLVEPDLVTAAAANLAGIRSALSEAAAAASTPTTALASAGADEVSAAVSRLFGAYGQQFQALNARAATFHAEFVSLLNGGAAAYTGAEAASVSSMQALLDAVNAPTQTLLGRPLIGNGADGVAGTGSNAGGNGGPGGILYGNGGNGGAGGNGGAAGLIGNGGAGGAGGAGGAGGAGGAGGTGGLLYGNGGAGGNGGSAAAAGGAGGNALLFGNGGNGGSGASGGAAGHAGTIFGNGGNAGAGSGLAGADGGLFGNGGDGGSSTSKAGGAGGNALFGNGGDGGSSTVAAGGAGGNTLVGNGGAGGAGGTSGLTGSGVAGGAGGSVGLWGSGGAGGDGGAATSLLGVGMNAGAGGAGGNAGLLYGNGGAGGAGGNGGDTTVPLFDSGVGGAGGAGGNASLFGNGGTGGVGGKGGTSSDLASATSGAGGAGGAGGVGGLLYGNGGNGGAGGIGGAAINILANAGAGGAGGAAGSSFIGNGGNGGAGGAGGAAALFSSGVGGAGGSGGTALLLGSGGAGGNGGTGGANSGSLFASPGGTGGAGGHGGAGGLIWGNGGAGGNGGNGGTTADGALEGGTGGIGGTGGSAIAFGNGGQGGAGGTGGDHSGGNGIGGKGGASGNGGNAGQVFGDGGTGGTGGAGGAGSGTKAGGTGSDGGHGGNATLIGNGGDGGAGGAGGAGSPAGAPGNGGTGGTGGVLFGQSGSSGPPGAAALAFPSLSSSVPILGPYEDLIANTVANLASIGNTWLADPAPFLQQYLANQFGYGQLTLTALTDATRDFAIGLAGIPPSLQSALQALAAGDVSGAVTDVLGAVVKVFVSGVDASDLSNILLLGPVGDLFPILSIPGAMSQNFTNVVMTVTDTTIAFSIDTTNLTGVMTFGLPLAMTLNAVGSPITTAIAFAESTTAFVSAVQAGNLQAAAAALVGAPANVANGFLNGEARLPLALPTSATGGIPVTVEVPVGGILAPLQPFQATAVIPVIGPVTVTLEGTPAGGIVPALVNYAPTQLAQAIAP
Mediates suppression of pro-inflammatory immune response in macrophages via modulation of host cytokine response . Required for full virulence. Involved in inhibition of phago-lysosome fusion .
Q79FL8
Q5G290
PA2A6_NAJSG
Phospholipase A2 molecule B
Naja
SNRPMPLNIKQFNNMIQCTVPARSWWDFADYGCYCGSGSGSPVDDLDRCCQVHDNCYNAGGGVTGCAPKSKTYTYECSQGTLTCSGENSACAATVCDCDRLAAICFAGAPYNDNNYNIDLKSRCQ
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Q5G290
A9G7Z8
Y5766_SORC5
Nucleotide-binding protein sce5766
Sorangium
MSNGGDQQQHGLLGPDGAPGRVVVVTGLSGAGKSTALHALEDLGFFCVDNLPTSLVQPAVEACESGGITRIGLGIDVRVGSFLAGATAALDSIRTGRDVVILFLDASDETLLRRFSETRRPHPLTTGGSGAIAMLDGVLLERERLASLRARATIELDTTRLSTHDLRRVVIERLRPARVEVPRMSTRFVSFGYKYGIPLDADLLFDVRFLDNPYFVHGLRELTGNDEPVREYILKNPDALEFICRTEQLLSFCMPRYASEGKSYLTVGIGCTGGRHRSVVLTNALSDSLRRKTGLPITVVHRDVARVSTSGVPSGVGEGMAGAPGVDLRLAQPGATPSEPRPASDTSVTGGER
Displays ATPase and GTPase activities.
A9G7Z8
Q9SZD4
PRS4A_ARATH
Regulatory particle triple-A ATPase subunit 2a
Arabidopsis
MGQGPSGGLNRQGDRKPDGGDKKEKKFEPAAPPARVGRKQRKQKGPEAAARLPTVTPSTKCKLRLLKLERIKDYLLMEEEFVANQERLKPQEEKAEEDRSKVDDLRGTPMSVGNLEELIDENHAIVSSSVGPEYYVGILSFVDKDQLEPGCSILMHNKVLSVVGILQDEVDPMVSVMKVEKAPLESYADIGGLEAQIQEIKEAVELPLTHPELYEDIGIKPPKGVILYGEPGTGKTLLAKAVANSTSATFLRVVGSELIQKYLGDGPKLVRELFRVADDLSPSIVFIDEIDAVGTKRYDAHSGGEREIQRTMLELLNQLDGFDSRGDVKVILATNRIESLDPALLRPGRIDRKIEFPLPDIKTRRRIFQIHTSKMTLSEDVNLEEFVMTKDEFSGADIKAICTEAGLLALRERRMKVTHPDFKKAKEKVMFKKKEGVPEGLYM
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (Probable). Interacts with transit peptides of proteins targeted to the chloroplast, and may be involved in the degradation of unimported plastid protein precursors . Is required for the maintenance of postembryonic root and shoot meristems . Has a specific role in the regulation of organs size . Acts redundantly with RPT2B in the regulation of gametogenesis . With RPT2B plays a critical role in 26S proteasome assembly . Acts as an upstream signaling component for inducing both defense and morphological phenotypes in the constitutive active uni-1D mutant . Acts as negative regulator of endoreduplication in trichome cells . May function after the completion of the third endoreduplication step (8C to 16C) mediated by RHL1 . Acts as negative regulator of transcriptional gene silencing (TGS) at specific endogenous genes through DNA methylation . Promotes post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS . Involved in tolerance to zinc deficiency, possibly through alleviation of oxidative stresses or processing of poly-ubiquitinated proteins . Required for resistance to the fungal pathogen Golovinomyces cichoracearum .
Q9SZD4
Q31AR4
TPIS_PROM9
Triose-phosphate isomerase
Prochlorococcus
MRKSVIAGNWKMHMTCAEAKSYLEEFIPLIKNIRDDRKVVIAPPFTAISTFSKHSDFDYLDISSQNIHWEDEGAFTAEISPKMLIEHGVSYAIVGHSEPRKYFSESDEQINKRAVFAQCSGLTPIVCVGETLEQRERGEADRVITRQVEQGLENTDPSNLIVAYEPIWAIGTGKTCEAKDANNICSLIRKLIGFDDVIIQYGGSVKPNNIDEIMSMSDIDGVLVGGASLDPNSFARIANYQ
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q31AR4
Q9CZD5
IF3M_MOUSE
Translation initiation factor IF-3, mitochondrial
Mus
MAVLLMRLMLQTTKLDHNLIGRCLQRHAVKPDPAQLSLSASTPKLLYLTSAKGFSTAGDPQGERKQKRRDAFSNTGRKISERIIRVLDEKGMDLGMMHRADVIRLMNKQDLRLVQRNTSSEPPEYQLMTGEQIHQERLKLREQEKAKPKTGPTMTKELVFSSNIGQHDLDTKSKQIQQWIEKKYHVQVTIKRRKDAEQSEEETEEIFNQILQTMPDIATFSSRPKAIRGGTASMCVFRHLSKKEEKAYRESQESQRRDTLSKDDDGNSKESDVVCQ
IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.
Q9CZD5
Q8YG94
RSMA_BRUME
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Brucella
MSIDSLPPLREVIERHDLMPKKSLGQNFLFDLNLTSKIARQAGDLRDQPVIEVGPGPGGLTRALLAQGAYVTAIERDDRCLEALAEIAAHYPGRLRIIAGDALEQDFTALFPEGPKPRIVANLPYNVGTQLLLNWLLVEPWPPFYSSMTLMFQREVAERIVAKLDSDHYGRLGVLAGWRTQAKIAFDVPPQAFTPPPKVMSSVVHIVPRETPLPCRAEALGQITQAAFGQRRKMLRQSLKSIGGAALLEKTGIDGTRRAETLSVEEFVALANACLP
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q8YG94
A7MB89
FEM1C_BOVIN
FEM1-gamma
Bos
MDLKTAVFNAARDGKLRLLTKLLASKSKEEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQNNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTLEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGHIPEKLETFVSLHR
Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding.
A7MB89
A5VJ98
UVRC_LIMRD
Excinuclease ABC subunit C
Limosilactobacillus
MASEHLEHKLALLPDKPGCYLMKNINDQIIYVGKAKNLKNRVRSYFKSSHTGKVAKMVSEVADFETIVTSTNKESFLLEITLIQKHQPYFNIKLKKGTGYPYIKITNERDPQIKIVSKIKKDGGYYFGPYPNVYAAEETMHFIQKVYPLRRCNGYQGRPCLYYHMGQCLGACFKEVPKSDYEEQIKKIKSFLSGNTATVKRQLTKKMQRAAENMEFERAAEIRDQLHYIEVTVEKQKIISNDKTPRDLFNFYMDKGWLSIQIFFIRQARLMKREKRLFPIVDTAVEEMTSFILQFYNRRNNILPHEILLPKGLPNKEISEILGVPVRTPVRGEKRDLLAMAHENAQLSLDEKFRLLEMDQSKTTGAMKEITDALGLPEGHRIEAFDHSHIQGADPVSAMVVFINGEPAKNFYRKYKLKTVINHADEAASTREVIRRRYSRLLKENKPMPDMIFMDGGEIQMDAAKDVLENELGLEIPVVGMVKNDKHQTADLLFGDDDHHINLNPRSQGFYLVQRIQDEVHRFAITFHRRVHTKHSLSSRLDEIKGVGPRTRTKLLKKYGSITKIAQASVDEIHSLGINRPTAQLIKVSLQKNAEVAKGSSHD
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A5VJ98
Q8BUM3
PTN7_MOUSE
Hematopoietic protein-tyrosine phosphatase
Mus
MVQACEGRSRAQLPTLSLGADMTQPPPTKAPAKKHVRLQERRGSSVALMLDVQSLGTVEPICSVNTPREVTLHFLRTAGHPLTRWTLQHQPPSPKQLEEEFLKIPSNFVNPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDSDYINANYIRGYDGKEKVYIATQGPMPNTVADFWEMVWQEDVSLIVMLTQLREGKEKCVHYWPTEEEAYGPFQIRIQDMKEHPEYTVRQLTIQHQQECRSVKHILFSAWPDHQTPESAGPLLRLVAEVETPETAANSGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAAQLPPEPNP
May play a role in the regulation of T and B-lymphocyte development and signal transduction.
Q8BUM3
O07592
YHDW_BACSU
Putative glycerophosphodiester phosphodiesterase YhdW
Bacillus
MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQIVVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKIGLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVITRPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKLQAMGVDGIVTDYPDFIIKDGKHENI
Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to sn-glycerol 3-phosphate (G3P) and the corresponding alcohols.
O07592
A6SVP5
ILVD_JANMA
Dihydroxy-acid dehydratase
Janthinobacterium
MAFNRRSKNITQGISRSPNRSMYYAMGYEKEDFDKPMVGVANGHSTITPCNSGLQKLADIAIKTIKDSGGNPQVFGTPTISDGMSMGTEGMKYSLISREVIADCIETAVNGQWMDGVLVIGGCDKNMPGGMIAMLRTNVPSIYVYGGTIKPGNWKGKDLTIVSAFEAVGEFTAGRMSQEDFDGIERNACPSAGSCGGMYTANTMSSSFEALGLALPYSSTMANPDDEKVGSAAESARVLIEAIKNDLKPRDIVTRKAIENAVAVIMATGGSTNAVLHFLAIAHAAEVEWTIDDFERMRKKVPVICDLKPSGKYVATDLHKAGGIPQVMKVLLDAGLLHGDCMTITGQTVAEALAHIPSVPRADQHVIHPIKDALYEQGHLAILKGNLSPEGCVAKITGLKNPVITGPARVFDDEYSAMDAIMANKIVAGDVLVMRYLGPKGGPGMPEMLAPTSALVGQGLGESVGLITDGRFSGGTWGMVVGHVSPEAFVGGLIGLVEEGDSVTIDAHKLLIQLNVPEEEIARRRANWKQPAPRYTRGVLSKFAALASSASKGAVTG
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
A6SVP5
Q9FMZ0
BKI1_ARATH
BRI1 kinase inhibitor 1
Arabidopsis
METNLQQVKNSSQTFSEKQNPKQEASPSPISSTCSSPSHDFSFTISLQPLSSSSKHISPTLRSPSKTTSSYQQTDPFAVDLSPADEIFFHGHLLPLHLLSHLPVSPRTSTGSYNDGFTLPVKDILPDQPTNNNNNTENAITNISTEAKDDNTEDKAEGEIRVKTKPIKSFSLFGLSKWRKGFESNEREQEQQQQKIKKPMSLDLSHAVKKYIRMLFQKRGNGTQFWNRRQTSSYSFSSSLMGPNGNSKTMINGSYNKRDLIRGRRGELFSAPASMRTSPTNSGHLRVSTAGLSSSSGSTSSSSSDSTMEELQAAIQAAIAHCKNSSAVDRDDKVKDS
Negative regulator of brassinosteroid signaling. When associated to the membrane, limits the interaction of BRI1 with BAK1 by binding to the kinase-inactive form of BRI1.
Q9FMZ0
Q74KS4
METK_LACJO
Methionine adenosyltransferase
Lactobacillus
MKKEKRLFTSESVSEGHPDKVADQISDAILDAILAKDPDGRVACETTVTTGLVLVVGEISTSAYVDIQSVVRKTILEIGYNRPELGFDGNNCAILVDIDEQSSDIADGVNESLETRENQQDKDDLDKIGAGDQGLMFGFAIKETPELMPLPISLAHSLMRRVASLRKEGRLDWLRPDAKAQVTVEYDDENKPKRIDTVVISTQTDATVSNDEIREAMIDMVIKKVIPSQYLDKDTKFLINPSGRFVIGGPKGDSGLTGRKIIVDTYGGYARHGGGAFSGKDLTKVDRSASYAARYVAKNIVAAGLAYQCEIQLAYAIGVAHPVSIMVDTHGTSKVSEDLLVEAVRNVFDLRPAGIIEMLNLKRPIYRQTAAYGHFGRTDVDLPWEHTDKVEALKTYVSEHAE
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
Q74KS4
Q9VZ09
SISA_DROME
Protein sisterless A
Sophophora
MERSHLYLPTLSYAAMGHVYAPYRGSSSPALSTASSTSSKPEQIEELVSQQLHHLKMHYADEEQRYVDQMLLENPIVVERRAPPPLKTELAMDCRGSGSGSGSGSGSDVKDAQRQRAESCRKSRYNNKIKKAKLRFRHKFVSGQLKKSAVMLDTMRDVIAQAERQLLERGYPAATLERMRATFGLEMEQ
Involved in sex determination and dosage compensation. Required for proper expression of Sxl in embryonic somatic cells. Also has an essential function in the yolk nuclei. Involved in endoderm migration and midgut formation.
Q9VZ09
A0A126GUP6
MP1_DROME
Melanization protease 1
Sophophora
MEPHFFFTVLWMLLMGTSSTYAQEIFGYCRTPDENSGTCINLRECGYLFELLQSEEVTEQDRRFLQASQCGYRNGQVLEKHFCFTNVQICCANSRMRNQQPQWGNHPQPTQTTKPTKRSGTKLLPMAPNCGENFGDRVVGGNETTKREFPWMALIEYTKPGNVKGHHCGGSLINHRYVLTAAHCVSAIPSDWELTGVRLGEWDASTNPDCTVGKNGRRDCNEPYVDYPVEERIPHPQYPGNSRDQLNDIALLRLRDEVQYSDFILPVCLPTLASQHNNIFLGRKVVVAGWGRTETNFTSNIKLKAELDTVPTSECNQRYATQRRTVTTKQMCAGGVEGVDSCRGDSGGPLLLEDYSNGNSNYYIAGVVSYGPTPCGLKGWPGVYTRVEAYLNWIENNVRA
Serine protease which plays an essential role in the melanization immune response by acting downstream of sp7 to activate prophenoloxidase (PPO1) . May function in diverse Hayan-dependent PPO1-activating cascades that are negatively controlled by different serpin proteins; Spn27A in the hemolymph and Spn77BA in the trachea . Regulation of melanization and PPO1 activation appears to be largely independent of the Toll signaling pathway .
A0A126GUP6
Q8NT90
HEM3_CORGL
Pre-uroporphyrinogen synthase
Corynebacterium
MTLKIGTRGSKLATTQAGTIRDQLKHYGRDAELHIVTTPGDVNMSPVERIGVGVFTQALRDVLHSGECDVAVHSMKDLPTATDPRFHLVVPTRADSREALIARDGLTLAELPEGAKVGTSAPRRISQLKAIRPDLEILPLRGNIDTRMGKVTSGELDAVMLAYAGLTRVGMQDRATEVFDADIIMPAPAQGALAIECRADDTETVRALNMLMHADTFVSAVAERTVLNRLEAGCTAPVAAHATLDGYSGDTMTLTAGVYALDGSDQLVFSAEGDGARPEELGELVAQQLIDAGAANLLGDRS
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Q8NT90
Q4ZWR7
FABZ_PSEU2
Beta-hydroxyacyl-ACP dehydratase
Pseudomonas syringae
MMDIKEIREYLPHRYPFLLVDRVTELDIENKNIRAYKNVSVNEPFFNGHFPEHPIMPGVLIIEAMAQAAGILAFKMLDSKPSDGTLYYFVGSDKLRFRQPVLPGDQLVLEAKFLSSKRQIWKFECKATVDGKAVCSAEIICAERKL
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
Q4ZWR7
A1VTF8
RPOB_POLNA
Transcriptase subunit beta
Polaromonas
MAYSFTERKRIRKSFGNRESVLTVPYLLQMQKDAYIAFLQADRAPQKRMVEGLQAAFQNAFPIVSHNGFVEMKFIEYNLAKPAFDVRECQTRGLTFASAVRAKVQLIIYDRESSTSQSKVVKEVKEQEVYMGEVPLMTDKGSFVINGTERVIVSQLHRSPGVFFEHDKGKTHSSGKLLFSARIIPYRGSWLDFEFDPKDILYFRVDRRRKMPVTILLKAIGLNHESILANFFVFDNFRLMDSGAQMEFVAERMRGEVARFDLTDKAGKVVVAKDKRITVRHTRELEQSGTTSISVPEDFLIGRVVAKNIIDTDTGEIIAKANDELTELLLKKLRTAGIQNLQVLYTNELDQGAYISQTLRADETADEFAARVAIYRMMRPGEPPTEDAVQALFQRLFYNPDTYDLSRVGRMKFNARVGRDESTGPMVMTNEDILAVVKILVDLRNGNGEVDDIDHLGNRRVRCVGELAENQYRTGLARIEKAVKERLGQAEQEPLMPHDLINSKPISAALKEFFGASQLSQFMDQTNPLAEITHKRRVSALGPGGLTRERAGFEVRDVHVTHYGRVCPIETPEGPNIGLINSLALYARLNEYGFIETPYRRVADSKVTMEIDYLSAIEEGKYVIAQANAALDNEGRLTGDLVSAREKGESILVSAERVQYMDVSPAQIVSVAASLVPFLEHDDANRALMGANMSRQAVPVLRPEKPLVGTGIERVAAVDSGTVVTATRGGVVDYVDATRIVVRVNDAEALAGEIGVDIYNLIKYQRSNQNTNIHQRPIVKMGDKLAKGDVVADGASTDLGEIAIGQNMLIGFMPWNGYNFEDSILISERVVAEDRYTSIHIEELVVMARDTKLGSEEITRDIPNLSEQQLNRLDESGIIYVGAEVQPGDTLVGKVTPKGETTLTPEEKLLRAIFGEKASDVKDTSLRVSQGSSGTVIDVQVFTREGITRDKRAQQIIDDELKRYRLDLNDQLRIVEADAFDRIEKLLIGKIANGGPKKLAKGTKLDKAYLTDVEKYHWFDIRPADDEVASQLESIKNSMEQTRHSFDLSFEEKRKKLTQGDELPSGVLKMVKVYLAVKRRLQPGDKMAGRHGNKGVVSKIVPVEDMPHMADGTPCDIVLNPLGVPSRMNVGQVLEVHLGWAAKGLGQRIGDMLQAESKVAELRQFMDTLYNKSGRTEDLASLSDEQVVEMAQNLTTGVPFATPVFDGASEADIMTMLQLAYPDAVAKAKGLTPTRTQAQLYDGRTGDAFERTTTVGYMHFLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYVLQEMLTVKSDDVVGRTKVYESIVKGEHAITAGMPESFNVLVKEIRSLGIDMELERS
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A1VTF8
Q87KA9
ATPE_VIBPA
F-ATPase epsilon subunit
Vibrio
MAPITFHLDVVSAEKRIFSGRVETFQVTGSEGELGIFHGHTPLLSAIKPGMVRIVKQHGHEEFIYVSGGMVEVQPGTATVLADTAIRGEDLDAAKAEEAKRRAEEKIQNQHGDMDFAQAASELAKAIAQLRVIELTKKRR
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q87KA9
A8MC69
AROC_CALMQ
5-enolpyruvylshikimate-3-phosphate phospholyase
Caldivirga
MSSIGVVFRVTTFGESHGPAVGVVIDGVPAGIQLNEDYIRRELNRRRFCHIPVLNPRCEDEDFQILSGIKDGLTTGTPIAIVVWNKRAVSNYYMDIWMKPRPGHADLAWYLKFGKLYDFRGGGRASGRETVARIAAGAVAKAILKQTIDVDVSSHLIELGGVSISRDDYTFNDVAKSWEKPLPMIDDEAIEKAIKVLINAATEGDSVGGIGEVLTTEVPPGLGEPVFDKLKADLAKAVMSIPSTTGIEFGLGFKLARMRGSEANDQIVLRNGKPRLETNRVGGMLGGMSIGEPIRFRVAFKPTPSIRRPQRTVDLEKITETTITFTGRYDISTAPKAILAAEAMTAIILVDHAIRAGLIPRIIRK
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
A8MC69
Q6EJ97
ISPS_PUEML
Isoprene synthase, chloroplastic
Pueraria
MATNLLCLSNKLSSPTPTPSTRFPQSKNFITQKTSLANPKPWRVICATSSQFTQITEHNSRRSANYQPNLWNFEFLQSLENDLKVEKLEEKATKLEEEVRCMINRVDTQPLSLLELIDDVQRLGLTYKFEKDIIKALENIVLLDENKKNKSDLHATALSFRLLRQHGFEVSQDVFERFKDKEGGFSGELKGDVQGLLSLYEASYLGFEGENLLEEARTFSITHLKNNLKEGINTKVAEQVSHALELPYHQRLHRLEARWFLDKYEPKEPHHQLLLELAKLDFNMVQTLHQKELQDLSRWWTEMGLASKLDFVRDRLMEVYFWALGMAPDPQFGECRKAVTKMFGLVTIIDDVYDVYGTLDELQLFTDAVERWDVNAINTLPDYMKLCFLALYNTVNDTSYSILKEKGHNNLSYLTKSWRELCKAFLQEAKWSNNKIIPAFSKYLENASVSSSGVALLAPSYFSVCQQQEDISDHALRSLTDFHGLVRSSCVIFRLCNDLATSAAELERGETTNSIISYMHENDGTSEEQAREELRKLIDAEWKKMNRERVSDSTLLPKAFMEIAVNMARVSHCTYQYGDGLGRPDYATENRIKLLLIDPFPINQLMYV
Lyase that catalyzes the formation of isoprene from dimethylallyl diphosphate.
Q6EJ97
Q03957
CTK1_YEAST
CTD kinase subunit 1
Saccharomyces
MSYNNGNTYSKSYSRNNKRPLFGKRSPNPQSLARPPPPKRIRTDSGYQSNMDNISSHRVNSNDQPGHTKSRGNNNLSRYNDTSFQTSSRYQGSRYNNNNTSYENRPKSIKRDETKAEFLSHLPKGPKSVEKSRYNNSSNTSNDIKNGYHASKYYNHKGQEGRSVIAKKVPVSVLTQQRSTSVYLRIMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYFKEEPKPEPLVLDGLVSCHEYEVKLARKQKRPNILSTNTNNKGNGNSNNNNNNNNDDDDK
Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTDK-I phosphorylates 'Ser-5' if the CTD substrate is not phosphorylated at 'Ser-5', but will phosphorylate 'Ser-2' of a CTD substrate if 'Ser-5' is already phosphorylated. CTDK-I is also more reactive toward substrates that are prephosphorylated at 'Ser-2' or 'Ser-5' compared with an unphosphorylated CTD substrate, therefore efficiently creating doubly phosphorylated CTD repeats. Involved in RNA polymerase II transcriptional elongation, and through PTI1, pre-mRNA 3'-end processing. Participates in both positive and negative regulation of CTD phosphorylation. Required for DNA damage induced transcription, including the expression of the RNR genes, and reprogramming of gene expression upon amino acid starvation. Required for SET2 mediated H3K36 methylation. Also regulates H3K4 methylation. Controls the maintenance of suppressive chromatin in the coding regions of genes by both promoting H3K36 methylation, which leads to histone deacetylation, and catalyzing phosphorylation of the CTD required to localize H3K4 chromatin modification specifically to the 5' ends of genes, thereby creating a boundary for H3K4 methylation that prevents a mark associated with transcriptional initiation from spreading into the bodies of genes. Involved in RNA polymerase I transcription. Involved in telomere maintenance. Acts together with SNF1 to induce GSY2 transcription in response to glucose limitation. Involved in the adaptation to alternative carbon sources, including galactose, glycerol and ethanol, but not raffinose. Required for the integrity of the rDNA locus. Functions in translation elongation by enhancing decoding fidelity. Needed for translational accuracy by phosphorylating RPS2.
Q03957
Q5FG65
PYRH_EHRRG
Uridine monophosphate kinase
Ehrlichia
MSENSANELKYSRVLLKVSGEALMGDKGFGWDIETIDNLSHDLKEVHDLGVQLCLVVGGGNIFRGASASAPFGFERASNDYIGMLATMMNALSLQNSLEKINVQSRVLSAVSITAVCETYIRRRAIRHLEKGRIVICAAGVGNPFFTTDTAAALRGIEMGCNVIFKGTQVDGVYSADPKKVADAVRYDKISYRELLSLDLKIMDVAAVSLARDHSIPIIVFNLGKRGALADIICGGGLYTTIYN
Catalyzes the reversible phosphorylation of UMP to UDP.
Q5FG65
A8AB83
RADA_IGNH4
DNA repair and recombination protein RadA
Ignicoccus
MGQVATEEKRPTSVAELPGVGPSTAAKLIDAGYGTIEALAVATPEELVAIGIPLTTAQKIIRAARQMLDIRFRTAKEVKLERMNLRKITTGSKNLDDLLGGGIETKTITEFFGEFGSGKSQLCHQASVNVQLPLEQGGLSEGDKVAKAVYVDTEGTFRWERIEQMAKCLGLDPDQVMDNIYYIRAVNSDHQMAIVEELFNLVPKENVKLIVVDSVTSHFRAEYPGRENLAVRQQKLNKHLHQLGKLAEVYNTAVIITNQVMARPDVFYGDPTQAVGGHVLYHAPGVRVQLKKARGNKRIARVVDAPHLPEAEAVFAITDCGIRDPED
Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
A8AB83
Q1LI29
EFG1_CUPMC
Elongation factor G 1
Cupriavidus
MARKTPIERYRNIGISAHIDAGKTTTTERILFYTGVNHKIGEVHDGAATMDWMEQEQERGITITSAATTAFWKGMGGNYPEHRFNIIDTPGHVDFTIEVERSMRVLDGACMVYCAVGGVQPQSETVWRQANKYGVPRLAFVNKMDRTGANFFKVYDQLKTRLKANPVPVVVPIGAEDGFQGVVDLLEMKAIVWDEASQGVKFEYQDIPAELQATADEWREKMVESAAEASEELMEKYLGGEELTRAEIVKALRDRTIACEIQPMLCGTAFKNKGVQRMLDAVIDFLPSPVDIPPVKGVDESDDEKKLERKADDNEKFSALAFKIMTDPFVGQLIFFRVYSGKINSGDTVYNPVKQKKERLGRILQMHANQREEIKEVLAGDIAAAVGLKDATTGDTLCDPAAPIVLERMVFPEPVISQAVEPKTKADQEKMGIALNRLAAEDPSFRVRTDEESGQTIISGMGELHLEILVDRMKREFGVEANIGAPQVAYRETIRKKAEDVEGKFVKQSGGRGQYGHAVITLEPQEPGKGFEFIDAIKGGVIPREYIPAVEKGIVDTLPAGILAGFPVVDVKVTLTFGSYHDVDSNENAFRMAGSMAFKEAMRKASPVLLEPMMAVEVETPEDYTGTVMGDLSSRRGIVQGMDDMVGGGKIIKAEVPLSEMFGYSTALRSATQGRATYTMEFKHYAEAPKNIAEAVMTAKGKQ
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Q1LI29
Q9CAH0
MORF7_ARATH
RNA editing-interacting protein 7
Arabidopsis
MARIIRRPLNLTAAVRFRLSPLSPFSGNSGSINSETTSWSELIRVPSLVEGCDYKHWLVLMKPPNGYPTRNHIVQSFVETLAMALGSEEEAKRSIYSVSTKYYYAFGCRIHEPLTYKIRSLPDVKWVLPDSFIVDGDNRYGGEPFVDGEVVPYDEKYHADWLRDQTDEDAKSGVVKKKHRRKRKKKLI
Involved in organellar RNA editing. Required for the processing of few RNA editing sites in mitochondria.
Q9CAH0
A1T9N3
UREF_MYCVP
Urease accessory protein UreF
Mycolicibacterium
MSSLATLLVLSDSRLPTGGHVHSGGVEEAVSSGLVVDLATLRAYLTRRIRTSGLVTASLAAAVHRGSLPAAAGEAGDAETDARTPSPAARAASRAQGRGLVRLARRVWPEQDWDGLGATPHLAVAAGVAGRAGGLAPDHTALSVVYTTMTGSATAAQRLLALDPGDVAAVTFALSPLCEHTAAEAAKELADLSDPLLDVLAQRHLERERPLFAS
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
A1T9N3
B1J265
GLMM_PSEPW
Phosphoglucosamine mutase
Pseudomonas
MSRKYFGTDGIRGRVGEYPITPDFMLKLGWAAGMAFRKQGNCRVLVGKDTRISGYMFESALEAGLSAAGADVLLLGPMPTPAIAYLTRTFHAEAGIVISASHNPHDDNGIKFFSGQGTKLPDEIELMIEELLDQPMTVVDSSKLGKVSRINDAAGRYIEFCKSSVPTSTGFEGLKLVVDCAHGATYKVAPSVFRELGAEVTVLHAQPDGLNINENCGSTHIESLQAAVLVGHADLGIAFDGDGDRVLMVDHTGAIVDGDELLFIIARDLHERGKLQGGVVGTLMSNLGLELALKDLDIPFVRAKVGDRYVMAELLERGWLVGGENSGHVVCCNHTTTGDAIIAALQVLLALRRRGETLAQARQALRKCPQVLINVRFGASKVDPLEHPAVKEASARVTEDMAGRGRVLLRKSGTEPLVRVMVEGDDENQVRTHAEALAKLVAEVCV
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
B1J265
Q39JU3
SYP_BURL3
Prolyl-tRNA synthetase
Burkholderia cepacia complex
MKASRFFIGTLKEAPADAEIVSHKLMVRAGMIRRVAGGIYNYLPVGLRSIRKVEAIVREEMNRAGGIELLMPAVQPAELWQESGRWEQYGPELLRFKDRKDNDFVIGPTHEEVITDIARNQIKSYRQMPVNFYQIQTKFRDEIRPRFGVMRGREFIMKDAYSFDKDAAGLNESYRKMYDAYVRIFTRLGLEFRAVAADSGSIGGNFSHEFHVIADTGEDAIAYCPTSEFAANIEAAEALPLIAERAAPAEAMEKVATPGKAKCEAVAELLAIPLERTIKSIVLATDNEGAEPTIWLVMLRGDHDLNEIKVSKLPGLKNHRFATEQEIVEWFGTPPGYLGPVGTKKPVKVIADRTVANMSDFVVGANEVDYHIAGVNWGRDLPEPDVADVRNVKKGDPSPDGKGVIDICRGIEVGHVFQLGTKYSEAMGATFLDESGKPQPMLMGCYGVGVTRILGAAIEQNFDDKGIIWPESIAPFEVVLCPMGYDRSDMVRETADKLYAELVAAGIDVILDDRGERPGVMFADWELIGVPHRLVIGERGLKEGKIEYQGRRDAEATLLPADAAAATVAEKIRAALAR
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Q39JU3
Q47ZY2
QUEC2_COLP3
Queuosine biosynthesis protein QueC 2
Colwellia
MKKLVVIYSGGMDSFTALNKAVKEGFDVYALSFDYGQKHNKELIYAQNVCNELNVPHKILDIKSISTLFTSSSLVSDDINVPDGHYEADNMKSTVVPNRNMILISLAIGYAVDIEAEGVWYGAHSGDHLIYPDCRPEFVKVMDQASKVANFEPVYVHAPYLNTDKIGILKDGIKMGLDYSKTWTCYQGKEKACGTCGSCVERLEAFQANNIDDPVQYSI
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
Q47ZY2
Q83CP8
SCPA_COXBU
Segregation and condensation protein A
Coxiella
MENQEVVNQLAGFEVKVSGQPLSKLPEDLYIPPDALRVFLEAFEGPLDLLLYLIKKHNIDILDIPIAEITRQYMQFVDLMREMRIELAAEYLVMAAMLAEIKSRLLLPRPVVEEENEQDPRAELVRRLQEYERYKKAAYDLDQLPRVGRDTFIADAAVPPMNTAKIHPTAELPELLNALKDVLQRASLYNAHSIAREPLSIRERMSRILSLVDKENFIAFTRLFTVEEGRMGVVVTLIATLELIRQSVIELVQAEPFALIHIRAKG
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
Q83CP8
A8HT29
GCSPA_AZOC5
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Azorhizobium
MRYLPLTPEDRTEMLARIGAPSVDALFADIPAAKLDPALADLPAHKTELSVERTLGALSAQNVPAGSVPFFVGAGAYRHHVPATVDHLIQRSEFLTSYTPYQPEIAQGTLQYLFEFQTQVGELTGMEVANASMYDGSTAAAEAVLMAHRVTKRRKAVVAGNVHPHYRETIATLSLYADDAVVALSPVPQGGEDILSAIDGETSCVVVQSPDVFGNIVDLKPIAEKAHAAGALLIAVFTEVVSLGLIEPPGAQGADIVVGEGQSIGNPLTFGGPYVGLFATRQKYVRQMPGRLAGETVDASGKRGFVLTLSTREQHIRREKATSNICTNSGLCALAFTIHLTLLGETGLRKLARLNHANACKLADKLAAVPGVQVLNSAFFNEFTLRVPGKAVDVIEKLAAKGVLGGVPYARLAPKAGLDDLILVAATEINTDEDRAAYAAALKEVLA
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
A8HT29
Q2GH18
PLSX_EHRCR
Phosphate-acyl-ACP acyltransferase
Ehrlichia
MSIISIAVDAMGGDFAPEAVVSGLDFALTNLLDDQNVSFNIYGQGSQVLPILDKYKDLKEHSVFIDTPEVVLANDKPSFALRKRRSSSMWCAIDSIKSGVTSGVVSSGNTGALMAISRFLLGTLPNIDRPAICTALPSRGEEYFVLLDLGANIESSSNALFQFAIMGSAFAKAVLNIASPKVALLNVGQEEVKGTDVIREAFLLLKQAEGRINFCGYIEPIDILGDKVDVVVTDGFCGNIVLKVAESIAYTFKSVFEKSVTSSIISKFAGLLLKSQMKKDFMRFNPKMYNGAMLLGLNGVVVKSHGNADKVAFAHAIKVTVNAVRNDINAKIIHELS
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
Q2GH18
Q89Z26
MNME_BACTN
tRNA modification GTPase MnmE
Bacteroides
MNQDTICAIATAQGGAIGSIRVSGPEAISITSRIFQPAKAGKLLSEQKPYTLTFGRIYNGEEVIDEVLVSLFRAPHSYTGEDSTEITCHGSSYILQQVMQLLIKNGCRMAQPGEYTQRAFLNGKMDLSQAEAVADLIASSSAATHRLAMSQMRGGFSKELTDLRSKLLNFTSMIELELDFSEEDVEFADRSALRKLADEIEQVISRLVHSFNVGNAIKNGVPVAIIGETNAGKSTLLNVLLNEDKAIVSDIHGTTRDVIEDTINIGGITFRFIDTAGIRETNDTIESLGIERTFQKLDQAEIVLWMVDSSDASSQIKQLSEKIIPRCEEKQLIVVFNKADLIEEMQKEELSALLKNFPKEYTKSIFISAKERRQTDELQKMLINAAHLPTVTQNDIIVTNVRHYEALSKALDAIHRVQDGLDSHISGDFLSQDIRECIFFISDIAGEVTNDMVLQNIFQHFCIGK
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q89Z26
Q31ZN0
DADA_SHIBS
D-amino acid dehydrogenase
Shigella
MRVVILGSGVVGVASAWYLNQAGHEVTVIDREPGAALETSAANAGQISPGYAAPWAAPGVPLKAIKWMFQRHAPLAVRLDGTQFQLKWMWQMLRNCDTSHYMENKGRMVRLAEYSRDCLKALRAETNIQYEGRQGGTLQLFRTEQQYENATRDIAVLEDAGVPYQLLESSRLAEVDPALAEVAHKLTGGLQLPNDETGDCQLFTQNLARMAEQAGVKFRFNTPVDQLLCDGEQIYGVKFGDEVIKADAYVMAFGSYSTAMLKGIVDIPVYPLKGYSLTIPIAQEDGAPVSTILDETYKIAITRFDNRIRVGGMAEIVGFNTELLQPRRETLEMVVRDLYPRGGHVEQATFWTGLRPMTPDGTPVVGSTRFKNLWLNTGHGTLGWTMACGSGQLLSDLLSGRTPAIPYEDLSVARYSRGFTPSRPGHLHGAHS
Oxidative deamination of D-amino acids.
Q31ZN0
Q13VN6
EFP_PARXL
Elongation factor P
Paraburkholderia
MKTAQELRTGNVVMIGADAMVVQKAEYNKSGRNSAVVKMKFKNLLTGAGMESVYKADDKFDVVVLERKEVTYSYFADPMYVFMDADYNQFEVESEMMGDALHYLEDGMACEVVFYNDKAISVELPTTLVREIIYTEPAVKGDTSSGKVLKNAKLNTGFELQVPLFCNIGDKIEIDTRTHEYRSRA
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
Q13VN6
Q7TT23
DAAF9_MOUSE
Dynein axonemal assembly factor 9
Mus
MDSFDPQQLGLSPARFAGTFGSGAASVSCSRLRQVQSVLTQSSKSQPDGILCILGIDSRYNEGCRELANYLLFGLYSQNATDFEKTGFSEEILDDVILLIKSDSVHLYCNPVNYRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKISSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVEKWPIVQAFALEGIGGDGFFTMKYELQDVSLSLWNVYSRMDPASLENMLSEDLAVFEHQWTSFFANFDTEIPFLLELSESQAGEPFRSYFGHGMLSSHITENSPHRQPFVLFGNHSTRDNLSAGSFNFPSEGHLVRNTGPAGSFAKHMVAQCVSPKGPLACSRTYFFGATHVPYLGDNEKLPRTTEQIRLLSQIYAAVIEAVLAGIACYAKTCSLAKAKEVAEHTLESGLVFTELVPFKADLRSKVTFHIHAVNNQGRIVPLNNEDSLSFVKTARMTVYDIPDLLGGGGGGCLGSVVFSESFLTSRILVKEKDGTITPETSYIILTAAIPRFCSWLVEDSEIKLSEKTLQATKGDDCCLGTLLTGGKGAYLYSNSPQSGPEEGSAYFFSGGLLFSHRHHGSIVIAKEHVDAFSFYDGDSTSVVAALLIHFRSSILPHLPVHFHGSSNFLMLALFPKSKIYQAFYSEVFSPWQQQDNSGLSLKVIQEDGLSAEQKRLHSNAQKLFSALSPPAQDWSSPKLLSGKLPELDRFLQHFAIGSIGQEPVMRAHLVGLLQQPEMSPAHEVESDKVVISIVTGLPGCHASKLCAFLITLHKEYGRWMVYRQIMDSSECFHAAHFQKYLSSALEAQQNRSARQSAYIRKKTRLLVVLQGYTDVIDVVQALQTHPDPNVRSYFTIGAVTVCVEPLSCYMEHRFLFPKCLDQCSQGVVSNVVFTSHTAEQKHPLLVQLQTLIRASNPTAAFILAENGIVTRNEDIELILSENSFSSPQMLRSRYLLFPGWYEGKFDAGSVFPLMVQICVWFDCPLEKTRFVSRCRAIQSSIKPSPFSGNIYHILGKVKFSDSEKTMEVCHNTLTNSLTIVPVLEGPTPPPNSRSSPQDNGQPECYLVFIGCSLKEDSLKDWLRQSAKQRPQRKALKTRGMLTQQEIKNIHVKRHLDPLPAGYFYNGTQFVNFFGDKTDFHPLMDQFMNDYVEEANREIERYNRELEQQEYRDLFEQKPKP
May act as an effector for ARL3.
Q7TT23
A9IW26
RL4_BART1
50S ribosomal protein L4
Bartonella
MDLVIKTLDGHEAGKLKVSESIFDLVPREDILQRVVRWQLARRQQGTHQSQGRSDVSRTGAKMFKQKGTGRARHSSARAPQFRGGGKAHGPVFRSHAHDLPKKIRALGLRLALSAKLKAKDLIVVDELAVKDAKTKKLVSHFSKLGFNNALLIGGQEIDINFFRAASNIPNIDVLPIQGINVYDILRRSKLVLSKAAVEALEERFR
Forms part of the polypeptide exit tunnel.
A9IW26
Q5XDG5
YBEY_STRP6
Endoribonuclease YbeY
Streptococcus
MYIEMIDETGQVSQEIMEQTLDLLNFAAQKTGKEEKEMSVTFVTNERSHELNLEYRDTDRPTDVISLEYKPETPILFSQEDLAADPSLAEMMAEFDAYIGELFISIDKAREQSQEYGHSFEREMGFLAVHGFLHINGYDHYTLEEEKEMFTLQEEILTAYGLTRQ
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q5XDG5
B1WZT9
RS20_CROS5
30S ribosomal protein S20
Crocosphaera subtropica
MANSKSALKRIRTSERNRLRNKSYKSAVRTLMKKYLQAVEEYAASPTPENKAVVDQRMSAAYSKIDKAVKRSVLHRNNGARKKARLAKALQQVASAS
Binds directly to 16S ribosomal RNA.
B1WZT9
Q9D011
MPLKI_MOUSE
TTD non-photosensitive 1 protein homolog
Mus
MHRPNFRPPTPPYPSPGIGGWGGGNNFRGALGGGPRPPSPRDGYGSPHHTPPCGPRARPYGSSQSPRHGGNFSGARFGSPSPGGYPGSYSRSPAGSQHQFGYSPGQQQTYPQGSPRTSTPFGSGRGREKRMSNELESYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFS
May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis.
Q9D011
Q602E7
MNMG_MESH2
Glucose-inhibited division protein A
Mesomycoplasma
MSKKSKNSSIEFDAIVVGGGHAGIEAVYALLKKKLKVVLITLDKKKLASMPCNPAIGGPAKGIITREIDALGGVQGKLSDLAMIQIKYLNESKGPAVLAIRAQIDKEKYSKLILKDLKKQENLLIIEDLVSELLVEKNRVFGLKTAKKQVFFSKTVIITTGTYMDSKVLRGSLAIPSGPDGQQTSNLLSNNLKTLGFELQRLKTGTPPRIFTSSIDFSKVEKEVLPVYNINFSFQSKHKLKKQISCYLTYTTAKTHDIINKNLGKSSMYSGLISGVGPRYCPSIEDKIVRFSEKPRHQIFFEPETKKQDIMYINGLSTSMPEDVQLEMVKTIPGLENAKIAKFGYAIEYDALNPLELKKSLETKRVKGLFMAGQINGTSGYEEAAAQGLVAGINAGQFVLGKKPVEILRNDGYIGVLIDDLVTKGTKEPYRMLTSRAEYRLILRNDNADIRMAKYALKSGLISKKEYLKIKAKYAKIDRKILELSKEFVSPKDELAKKYNLEKRISKLKLISWPNVNFKDILPDFEFGYELTVMARLKGYIQKQNSEAQKMIRLEKLLIPGELNYEKVANLSSEALDKFQKVRPKTIGEASRISGVNPADIQMLLFHIKVLKMQKVSKI
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q602E7
Q71E89
CYB_MUNMN
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Mungos
MTNIRKSHPLIKIINESFIDLPAPSNISAWWNFGSLLGACLILQILTGLFVAMHYTSDTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHIGRGMYYGSYSFMETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAVPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFVISALAAVHLLFLHETGSNNPSGIPSDSDKIPFHPYYTIKDMLGLLIMFTALMTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPYKLGGVLALILSITILAIVPLLHTSNQRSMMFRPLSQCLFWLLAADLLTLTWIGGQPVEYPFIIIGQLASILYFLIILVLMPISGIIENHLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q71E89
P51465
HBAB_LITCT
Hemoglobin alpha-B chain
Lithobates
MPFSASDRHDITHLWEKMAPNVEFLGEEAMERLFKSHPKTKTYFSHLNVEHGSAAVRAQGAKVLNAIGHASKNLDHLDEALSNLSDKHAHDLRVDPGNFHLLCHNILVVLAIHFPEDFTPRAHAAFDKFLAAVSETLYSKYR
The alpha-B chain is a component of adult hemoglobin B.
P51465
Q9V8F5
BM23_DROME
Immune-induced peptide 23
null
MKCLILSFAIFVVLASQATAGNVIIGGVCQDCSPPVAENVVVGGQSYRTGRPGQGTVYINSPGAYLGALDGPIRRTGAGGGGGGGAQYPDGYSGRLPGGTYLHNKDCVGCSISGGGD
Secreted immune-induced peptide induced by Toll signaling . Has a role in resistance to bacterial and fungal infections .
Q9V8F5
Q475N7
MIAB_CUPPJ
tRNA-i(6)A37 methylthiotransferase
Cupriavidus
MKKVFVKTYGCQMNEYDSDKMVDVLNASQGLEPTDNVEDADVILFNTCSVREKAQEKVFSELGRMKALKAVKPDLVIGVGGCVASQEGASIVSRAPYVDVVFGPQTLHRLPDLIARRQRTGQSQVDISFPEIEKFDHLPPARVEGPSAFVSIMEGCSKYCSYCVVPYTRGEEVSRPFEDVLAEVAGLAEQGVREVTLLGQNVNAYRGAMGGTSEIADFALLIEYVAEIPGIERIRYTTSHPKEFTSRLVELYGRCDKLVNHLHLPVQHASDRVLMAMKRGYSVLEYKSIIRRLRMLRPDMSMSSDFIVGFPGETDADFDKLMALIEEVGYDTSFSFIFSPRPGTPAANLHDDTPHEVKLRRLQHLQATIEENVQRISRNMVGSVQRILVEGPSRKDPTELHGRTENNRVVNFALPGVPQAQRDRMIGQMVDVSITQAFPHSLRGEIVVRQ
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Q475N7
B9MLD4
FABZ_CALBD
Beta-hydroxyacyl-ACP dehydratase
Caldicellulosiruptor
MYNIDKILEIIPHRYPFLLVDRIIEVEEGKRAKGIKNVTINEPFFQGHFPSNPVMPGVLIVEAMAQVGAVAMLLKEEFKGKTPFFAGIDKVRFKKVVKPGDVLVIETELISLKGSIGKAKAVAMVDGEVVCEGELLFAIK
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
B9MLD4
A7EWL8
THI4_SCLS1
Thiazole biosynthetic enzyme
Sclerotinia
MAPPSAVEANSPIDGVHLKSAFEVKAVHAQTASQGKTLAELAEKWDQGFTFAPIRESQVSRAMTRRYFKDLDTYAESDVVIVGAGSCGLSTAYMLGKARPDLKIAIIEASVSPGGGAWLGGQLFSAMVMRKPADAFLIDLGVPFEDEGDFVVVKHAALFTSTLLSKVLAFPNIKLFNATSVEDLITRQTADGNIRIAGVVTNWTLVTMHHDDQSCMDPNTINAPIVISTTGHDGPFGAFCVKRLVSMNQIKELGGMRGLDMNVAEDAIVKKTREIVPGLIVGGMELSEVDGANRMGPTFGAMALSGVKAAEEALKVFDERKAQNAY
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
A7EWL8
Q7VRV8
NUOH_BLOFL
NDH-1 subunit H
Candidatus Blochmannia
MNISFEKFLECLSIFMHSFFVLLMVVMCGAYMSFVERRLLALFQNRYGPNRVGWNGSLQLLADLIKIMFKEDWIPPFSDRYIFVLAPAIAFIISLMIIPVIPFTPSSVILHCNVGVLFFLMISALTVYSVLLAGWSSNNKYALIGAVRSIAQTLSYEVFLGLSLMGIVAKSGSFDLLNIVQDQKYLWNIVPQFLGFVVFFISGMALCHRHPFDQPESEQELVAGYHIEYSGMKFSLFFISEYISVISISSFMVTLFFGGWYGPWFPPVVWFIIKTFMIVLFFVLIRASLPRPRYDYVMLVGWKFLLPIALLNLLVTAGYILI
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.
Q7VRV8
A4VXL3
ILVC_STRSY
Ketol-acid reductoisomerase type I
Streptococcus
MTVTMQYEKDVTVAALDGKRIAVIGYGSQGHAHAQNLRDTGHDVIIGVRAGKSFDKAKEDGFETFEVAEAAKQADVIMILAPDEIQADLYNEEIAPNLEAGNALGFAHGFNVHFEFIKVPADVDVFMCAPKGPGHLVRRTFEEGFGVPALYAVYQDATGNAKHIAMDWAKGVGSARVGLLETTFKEETEEDLFGEQAVLCGGLTALMQAGFEVLTEAGYAPELAYFEVLHEMKLIVDLVYEGGFKKMRQSISNTAEFGDYVSGPRVITDQVKENMKAVLADIQSGKFANDFVNDYKAGRPRMEAYRKEAENLEIEKVGAELRKAMPFVGRNDDDAFKIYN
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
A4VXL3
Q15W54
RF3_PSEA6
Peptide chain release factor 3
Pseudoalteromonas
MSNALVPQEVSRRRTFAIISHPDAGKTTITEKVLLFGNALQRAGTVKGKKSGQHAKSDWMEMEKERGISVTTSVMQFPYSDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEARTIKLMEVTRLRDTPIITFMNKLDRDTRDPIDLLDEVESVLNIKCAPITWPIGMGKEFKGVYHLLRDETILYSTGQGHTIQEKRVIKGLDNPELDTAIGDYAEELRDMLDLVKGASHEFNHEEFIAGELTPVFFGTAMGNFGVDHMLDGLVDWAPSPQGRETDQGKVEAKDEKFSGFVFKIQANMDPKHRDRIAFCRIVSGKYQKGMKMHQSRIGKDVRISDALTFLAGDRELLEEAYAGDIIGLHNHGSIQIGDTFTSGDKFRFAGIPNFAPELFKRIRLRDPLKQKQLLKGLIQLSEEGAVQVFRPLQNNDLIVGAVGVLQFDVVVARLKGEYNVDAMYEHINVATARWIYGKDERKVDEFRRKAEANLALDGGDNLTYIAPTMVNLSLAQERYPEIEFHQTREH
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
Q15W54
Q8FQ22
ATPA_COREF
F-ATPase subunit alpha
Corynebacterium
MAELTISSDEIRSAIANYTSSYSAEASREEVGVVISAADGIAQVSGLPSVMANELLEFPGGVIGVAQNLDTDSVGVVVLGNYELLKEGDQVRRTGDVLSIPVGEKFLGRVINPLGQPIDGLGEIVAEEDRVLELQAPSVLERQPVEEPMATGIKAIDAMTPIGRGQRQLIIGDRKTGKTAVCVDTILNQKANWETGDKTKQVRCIYVAIGQKGSTIAALRKTLEEQGALEYTTIVAAPASDAAGFKWLAPFAGAALAQHWMYQGNHVLVIYDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDLGAGSITALPIIETKANDVSAFIPTNVISITDGQVFLESDLFNRGVRPAINVGISVSRVGGAAQTKGMKKVAGSLRLDLAAYRDLEAFATFASDLDAASKAQLERGQRLVQLLIQSENAPQAVEYQIISLWLAGEGAFDNVPVDDVRRFETELHEYLGSNAPQVYEQIAGGAVLSDESKETLLQATEQFKGTFQTTDGTRIINEPEVDALDAGQVRKDQLTVSRKVGK
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Q8FQ22
Q94570
TBA2_HOMAM
Alpha-II tubulin
Homarus
MRECISIHVGQAGVQMGNSCWELYCLEHGIQPDGQMPSDKTVGVCNDSFNTFFTETGSGKHVPRAVFVDLEPSVIDEVRSGIYRQLFHPEQLISGKEDAANNYARGHYTIGKEYVDIVLDRIRKLADQCTGLQGFLIFRSFGGGTGSGFASLLMERLSVEYGKKSKLEIAIYPAPQSATSVVEPYNSILTTHTTLEHSDCCFMVDNEAIFDICQRNLDVSRPTYTNLNRLIGQIVSSITASLRFEGALNVDLTEFQTNLVPYPRIHFPLTTYSPIISAEKAYHEQLSVGEITSACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVTASIANVKTKRTIQFVDWCPTGFKVGINYQPPTVVPGADLAKVSRAVCMLSNTTAIAEAWARLDHKVDLMYAKRAFVHWYVGEGMEERQFSEAREDLATLEKDYEEVGIDTADGEDDEEANDY
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q94570
P02415
RL16_MYCCT
50S ribosomal protein L16
Mycoplasma
MLQPKRTKYRKPHRVSYEGKAKGAKEINFGEFGLMALDGAWIDNHQIEAARIAMTRYMKRDGKIWMRIFPHMAMTKKPAEVRMGSGKGNPEKWVAVVKKGTIMFEVAQVNEQVAREALRLAMHKLPIRCKFVKRGEN
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
P02415
B7IYH2
LEPA_BACC2
Ribosomal back-translocase LepA
Bacillus cereus group
MNKEERAKRQSKIRNFSIIAHIDHGKSTLADRILEKTNALTQREMKAQLLDSMDLERERGITIKLNAVQLNYKAKDGEEYILHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNNLEILPVINKIDLPSADPERVRQEVEDVIGLDASEAVLASAKAGIGIEEILEQIVEKVPAPAGDSEEPLQCMIFDSLYDPYRGVIAYIRVVNGTVKVGDKVRMMATGKEFEVTEVGVFTPKTTQRDELTVGDVGFLAASIKNVGDTRVGDTITHAKRPAAEALPGYRKLNPMVFCGLYPIDSARYNDLRDALEKLELNDSALEFEPETSQALGFGFRCGFLGLLHMEIIQERIEREFKIDLITTAPSVIYKVYLTNGEDVIVDNPSNMPDPQSIDRVEEPFVKASIMVPNDYVGAVMEICQGKRGTFIDMQYLDETRVTLTYEIPLSEIVYDFFDQLKSNTKGYASFDYELIGYKPSKLVKMDILLNNEQVDALSFIVHRDSAYDRGKVIVEKLKELIPRQQFEVPIQATIGNKVVARSTIKAMRKNVLAKCYGGDISRKRKLLDKQKEGKKRMKSVGSVEVPQEAFMAVLKMDDN
Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.
B7IYH2
A4TDU4
NRDI_MYCGI
Protein NrdI
Mycolicibacterium
MANIVYFSSVSENTHRFVQKLELPAIRIPLKDRIRVEEPYVLILPTYGGGHANGPDPDRGGYVPKQVIAFLNDEHNRSLIRGVIAAGNTNFGAEFGYAGVVVSRKCDVPFLYRFELMGTTDDVFAVRAGLQDFWKDQSCPQPSQLQNR
Probably involved in ribonucleotide reductase function.
A4TDU4
Q6NHJ8
COAD_CORDI
Pantetheine-phosphate adenylyltransferase
Corynebacterium
MRKAVCPGSFDPVTMGHLDIIGRAAQQYDEVTVLVTANPNKPSGMFTVDERLALIKESTAHFVNVKVDNWAGLLVDYTTANGIDAIVKGLRTALDYEYELPMAQMNRKLAGVDTLFLMTDPQYGYISSTLCKEVTKYGGDVSDMLPPAVAAAIVEKVKS
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Q6NHJ8
O17386
CED8_CAEEL
Cell death abnormality protein 8
Caenorhabditis
MFLKKHKSKLLLVPRDEEQEDAGIVAVLTDRIPSVLLVRWFDLFCFGFAMCSYALDFFSDIGIAIFHFWAGRYLSGSLVLAFALLPSVIINIISMVWMLDDEMHWKRRAHPRRTGTFELNQKRFIPLSKMIVLCICQMGPLFWYYKALYYGWMFRKSSNENTDGEKRKCFSKMVEAERDATLLRFFEAFLESAPQLIIQGSIAASYFQNYYQTGTYPYWLYFQAASLLLSIISISWSVVVQNRSLRMIRDDKVNIWPHEAVLQFCWRFLTILARIITLVALVLIFGINVVPLISVHLLVTLVHVIFLQAIHIDACTHIEKLLLLINTFIHIFIPFNMVEGNTRWRYLTAYSVEFIEMMLVCWLLPLSLNTFPYIEKVQVGVPISFIAGIAIMMMYYQFFHPNRRQLIVTQSQEDLSLNVQKSVETLTPKLESSLEISGEQNTSQDLVSELLLDVEHEN
Phospholipid scramblase that acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface . Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment . Regulates apoptosis kinetics during embryonic development . Not required for engulfment of germ cell corpses .
O17386
Q92BX2
IDI2_LISIN
Type 2 isopentenyl diphosphate isomerase
Listeria
MQKNDDLLRERRKDEHVALGVKQNENLAPSSLEDIQLIGTSIPRYNVKDIDLTTTFLGATVPFPFYINAMTGGSRHTKRINAELAEIAREVAIPMAVGSQSAALKNSSLIDTYQVVREVNPKGIILANVSPEVDIQDGIRAIEMLEADALQIHINPAQELVMQEGDRSFSHWLSRIEAYVKNSPVPVVVKEVGFGMTRETVKTLAEIGVTTVDLAGKGGTNFAQIENDRRRDQAYNFLLDWGISTGQALIDMQHADAPKIAYLASGGIRNPLDIVKALALGADSVGMAGQIISSLKKDGVSKTIEKLELWKEQLRGLFVLANAKNIAELKETPLIVSGELAKWGSLREIDLVQLANRK
Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
Q92BX2
B6J630
DAPF_COXB1
PLP-independent amino acid racemase
Coxiella
MKVNFTKMQGSGNDFVVIDATKTPFQLTTSQIQKMANRRFGVGFDQLLVIEPPKNNSVDFHFRIFNADGSEVGQCGNGARCIARFIRAHQLSDREELRVSTLNEVLELKIQPDGKVSVKMGVPRFEPTEIPFIASGVANFYDIAVDNQIVKLGVVNIGNPHAIIPVERINAEEVGKLGARLSVHECFPEGANVGFMQVIDPQNIRLRVYERGTGETLACGSNACAAVAVGRRCGLLQERVVVSQPGGSLTIDWQGPLTPVTMTGPATTVFCGEWLD
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
B6J630
Q4ADG7
MX1_OTABY
Myxovirus resistance protein 1
Otaria
MVNSKGKITDSDPGSSHLLLNGLADKAGKNQDTEPENSLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLLNKDEWRGKVSYQDFEMEISDPSEVEVEINKAQNAIAGEGQGISHELISLEVSSPHVPDLTLIDLPGITRVAVGNQPADIGHQTKKLIKKYILKQETINLVVVPCNVDIATTEALSMAQEVDPDGDRTIGILTKPDLVDRGTESKVVDVAQNLVCHLKKGYMIVKCRGQQDIQDQVTLTEALQKERDFFEDHPHFRVLLEEGRATVPCLADRLTSELITHICKTLPLLEKQIKENYEKITEELQKYGSDVPEEEHEKMFFLIEKINAFNHDITSLTEGEEFVGEDECRLFTKIRNEFHKWSLVIEKRFQQGYKAICKQIERFENRYRGRELPGFVNYKTFEIIIKQQIKELEEPAVYMLHTITDMVQAAFTDISEANFAEFFNLYRTTKSKIEDIKFELEKEAEKSIRLHFQMEQIVYCQDQVYQCALQRVREESDKEKDKKINSMCSKEVSSVNISLSDIFEHLLAYRQEATNRISSHIPLIIQYFILQVYGQKLQKDMLLLLHDKDTHNWLLKERSDTRDKRKLLKERLARLAQARRRLAKFPG
Interferon-induced dynamin-like GTPase with antiviral activity.
Q4ADG7
Q8VXG7
PALY_MAIZE
Bifunctional phenylalanine ammonia-lyase
Zea
MAGNGAIVESDPLNWGAAAAELAGSHLDEVKRMVAQARQPVVKIEGSTLRVGQVAAVASAKDASGVAVELDEEARPRVKASSEWILDCIAHGGDIYGVTTGFGGTSHRRTKDGPALQVELLRHLNAGIFGTGSDGHTLPSEVTRAAMLVRINTLLQGYSGIRFEILEAITKLLNTGVSPCLPLRGTITASGDLVPLSYIAGLITGRPNAQAVTVDGRKVDAAEAFKIAGIEGGFFKLNPKEGLAIVNGTSVGSALAATVMYDANVLAVLSEVLSAVFCEVMNGKPEYTDHLTHKLKHHPGSIEAAAIMEHILDGSSFMKQAKKVNELDPLLKPKQDRYALRTSPQWLGPQIEVIRAATKSIEREVNSVNDNPVIDVHRGKALHGGNFQGTPIGVSMDNARLAIANIGKLMFAQFSELVNEFYNNGLTSNLAGSRNPSLDYGFKGTEIAMASYCSELQYLGNPITNHVQSADEHNQDVNSLGLVSARKTAEAIDILKLMSSTYIVALCQAVDLRHLEENIKASVKNTVTQVAKKVLTMNPSGELSSARFSEKELISAIDREAVFTYAEDAASASLPLMQKLRAVLVDHALSSGERGAGALRVLQDHQVRGGAPRGAAPGGGGRPRGVAEGTAPVANRIADSRSFPLYRFVREELGCVFLTGERLKSPGEECNKVFVGISQGKLVDPMLECLKEWDGKPLPINIK
Catalyzes the non-oxidative deamination of L-phenylalanine and L-tyrosine to form trans-cinnamic acid and p-coumaric acid respectively with similar efficiencies. Facilitates the commitment step in phenylpropanoid pathways that produce lignins, coumarins and flavonoids.
Q8VXG7
B5EQ29
CLPX_ACIF5
ATP-dependent Clp protease ATP-binding subunit ClpX
Acidithiobacillus
MAGKHEGSGEKTLYCSFCGKSQHEVRKLIAGPSVFICDECIELCNDIVKDEILDDHSEAQDKLPKPMEIRKTLDDYVIGQDVAKKVLSVAVYNHYKRLEHGGKDNEVELDKSNILLIGPTGSGKTLLAQTLARLLNVPFAMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQTGIVYIDEIDKITRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTRHILFICGGAFAGLEKSVSARLEKGGMGFNAPLKRRDKEATAAMLMQNLEPEDLVRYGLIPEFVGRLPILALLEELDEEALISILTDPKNALVKQYQKLFALEGVTLEFRTEALRAIAKKALARKTGARGLRSILEQILLDTMYELPSMSGVKKVVVDAAVVESGTKPLLVYDDAAKVDMSHPA
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
B5EQ29
Q2SWD1
KUP_BURTA
Probable potassium transport system protein kup
pseudomallei group
MTDTNHSSMRQHSLQSLAIAAIGVVFGDIGTSPLYSLKEAFSPAHGIPLTPSAILGVISLLFWAIILVVGIKYVLFVMRADNNGEGGVLALMALSLRPLNPKSRITGLMMALGIFGACMFYGDAVITPAISVMSAVEGLEVATPQLSHLVLPITIVILIALFWIQRHGTATVGKLFGPIMVIWFVTIAALGVYHIARAPMIVSAINPYYAFSFMSEHVLLAYVVLGSVVLVLTGAEALYADMGHFGAKPIRLAAYVLVMPSLVLNYFGQGALLLLDPKAIENPFFLLAPQWAALPLVVLSTVATVIASQAVISGAYSLTSQAIQLGYVPRMKILHTSELAIGQIYVPVVNWLLLFVILCIVIGFKSSDNLAAAYGIAVTATMVITTILAAVVMVKVWNWNKLLVAMIIGVFLVIDLGFFGANLLKVEQGGWLPLGIGALLFFLLMTWYKGRHIVKERTAADGIPLAPFLQGLLAHPPHRVSGTAIYLTGNDTLVPVSLLHNLKHNKVLHERTIFMTFVTRDIPYVKDDERVTVHDAGEGLYIVKAEYGFNETPDVKAVLEEVSCQRAMTFELMDTSFFLARETVVPTHLPGMSIWRERVFAWMHQNAAKPTDFFAIPANRVVELGTKIEI
Transport of potassium into the cell.
Q2SWD1
Q0HLE9
TYPH_SHESM
TdRPase
Shewanella
MFLAQEIIRKKRNGLALSAEEIQFFVKGITTNAVSEGQIAALGMAVYFNDMNMDERIALTTAMRDSGTVLNWQSLGLNGPVIDKHSTGGVGDVISLMLGPMAAACGGYVPMISGRGLGHTGGTLDKFDAIPGYQTEPSSELFRKVVKDVGVAIIGQTGDLVPADKRFYSIRDNTATVESISLITASILSKKLACSLDALAMDVKVGSGAFMPTYEASEELARSIAAVANGAGTKTTALLTDMNQVLASCAGNAVEVKEAIDFLTGAYRNPRLYAVTMGLCAEMLLLGGLATDEADARAKLNRVLDNGRAAEIFGKMVSGLGGPVDFVENYSKYLPQSQIIRPVFADTQGYAHSMDTRELGLAVVTLGGGRRKPGDALDYSVGLTQVCALGDKIDASTPIAVIHAQSEDAFAQAEEAVKKAIRIDEVAPEKTPEIYAYIRAADL
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
Q0HLE9
A1UKU2
ECTC_MYCSK
N-acetyldiaminobutyrate dehydratase
unclassified Mycobacterium
MIVRTTQAITGTERDVAAKDWRSKRIVLADDGVGFSFHETTINANSVSEFHYRHHVEAVWVVEGSGTLTDHETGEEFPLLPGTMYLLDGHERHRVTCHEQLRMLCVFNPPVTGQEVHDESGAYPAPVAS
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
A1UKU2
A0Q1U7
NADA_CLONN
Quinolinate synthase
Clostridium
MEIDLKDKIMKLKKEKNAVILAHFYQPKDVQEVADYIGDSYFLIDVGEKCKEDTIVFCGVKFMAESAKILSPNKKVIFPTPKAICPMANMITKEDVLKLKEKHPNAKVVCYINSTAEVKSVVDVCCTSSNAIEIVNNLESNEIIFLPDKNLGSYIQENTPNKKIILWDGYCYVHNKIKASDIIKAKEEYGNDINVLVHPECRKEVRELADYIGSTKGIINFAQNSNSKKYLIVTECGVIHELKKKNPDKEFYMLDMHCSNMKMNSIKEIYTCLKNYNNEVKIDENIKRKAVRALEKMHSL
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
A0Q1U7
Q9VAN6
SLBP_DROME
Histone stem-loop-binding protein
Sophophora
MLCEDQHMSVENTPQKGSGSLNSSASSISIDVKPTMQSWAQEVRAEFGHSDEASSSLNSSAASCGSLAKKETADGNLESKDGEGREMAFEFLDGVNEVKFERLVKEEKLKTPYKRRHSFTPPSNENSRSNSPNSSNSSANGDAAAPKGGNNPHSRNSKKSGNFRAHKEEKRVRHNSYTSSTSSSSSYTEADPAILSRRQKQIDYGKNTAAYERYVEMVPKDERTRDHPRTPNKYGKYSRRAFDGLVKIWRKSLHIYDPPTQARDTAKDSNSDSDSD
Involved in histone pre-mRNA 3' processing and couples histone mRNA production with the cell cycle. Both maternal and zygotic proteins play an essential and vital function for development.
Q9VAN6
Q83HW8
NADE_TROW8
NH(3)-dependent NAD(+) synthetase
Tropheryma
MCCDISKTLCVKPFIDPEEEISHRVSFLADYLRHSRASGYVLGISGGQDSALAGRLCQIAVESVRSIGFDATLWAIRLPYGQQFDESDAQTAMQFISPDEELSFDIRSATDNLCVDLNRSLGSKISDFNRGNIKARLRMVVQYAVAAHHDALVVGTDHAAEAVTGFFTKFGDGAADILPLYGLTKGQGRALLKALGACDSIIEKVPTADLLDDLPCLPDETELGLQYRDIDAFLEGKPVSEDITMAITERYKSTLHKRMPPITPHSTWWRK
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
Q83HW8
Q1QV22
YBEY_CHRSD
Endoribonuclease YbeY
Chromohalobacter
MTPDIDRQVALETATELLPTQADLEAWVGAVLARHPDTDRHELSVRFVTADESQALNRDYRGKDKPTNVLSFPFEAPPGLPLALLGDLAICHAVVVDEAAEQGKPLAHHYAHMVIHGTLHLLGYDHIDDREAEEMEALERELLAHFAIGDPYAE
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q1QV22
A8F4Q6
RS12_PSELT
30S ribosomal protein S12
Pseudothermotoga
MPTINQLIRLGRERKVEKPKAPALQGNPQKRGVCVRVTTMTPKKPNSALRKIARVRLSNGIEVTAYIPGIGHNLQEHSVVLVRGGRVKDLPGIRYKIIRGTLDTAGVENRKQSRSKYGAKRPKK
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
A8F4Q6
A4FLW9
RHMD_SACEN
L-rhamnonate dehydratase
Saccharopolyspora
MKIRQVRALTVTGGGADYHDQAEDHWIDDHVATPMAKYPEYRASRQAFGINVLGTLVVEVEAEDGTVGVGVTTAGEPGAYIVEKHLARFVEGASVTDVEKIWDQMFNATLYYGRKGLVLNAISAVDLALYDLLGKIRQEPVYALLGGPVRDELQCYATTGRPDVAKELGFLGGKMTLQHGPAEGVEGLHANIERLRKMREQVGPDFWLMFDCWMALDVEYATRLAHAAAEYDLKWLEEALIPDDYWGYGELRRRMPSTMLMTTGEHEHTRYGFRLLLEMGRPDIIQPDVNWCGGITELIKISALADAHGAMVVPHGSSVYSYHFVITRHNSPFTEFLMMHPQATEVVPMFSPLLLDEPVPVGGRLRLPETPGFGVRLNPEVELRRPYDHD
Catalyzes the dehydration of L-rhamnonate to 2-keto-3-deoxy-L-rhamnonate (KDR).
A4FLW9
B5XYH9
UBIB_KLEP3
Ubiquinone biosynthesis protein UbiB
Klebsiella
MTPGELRRLYFIIHTFLSYGLDELIPKIRLTLPLRIWRRMLFWMPNRHQDQPLGTRLRLALQELGPVWIKFGQMLSTRRDLFPPHIADQLALLQDRVAPFEGKLAQQQIEKAMGGLPVDAWFDDFSVEPLASASIAQVHTARLKENGKEVVIKVIRPDILPIIKADMKLIYRLARWVPRLLPDGRRLRPQEVVREYEKTLLDELNLLRESANAIQLRRNFEDSPMLYVPEVYPDYCSESMMVMERIYGIPVSDVEALEAQGTNMQLLAERGVQVFFTQVFRDSFFHADMHPGNIFVSYEHPEDPQYIGIDCGIVGSLNKEDKRYLAENFIAFFNRDYRKVAELHVDSGWVPPDTNVEEFEFAIRTVCEPIFEKPLAEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGVGRQLYPQLDLWKTAKPFLESWIKDQVGIPALVRAFKDKAPFWIERMPEIPELVYQSLQQSKQLQTSVDTIVRDMHVRHVRQGQSRYLFGIGAVLLLSGTLLFIHRPEWGMMPGWLMAGGVVTWLIGWRKTH
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
B5XYH9
Q9NFZ3
GBGE_DROME
Guanine nucleotide-binding protein subunit gamma-e
Sophophora
MDPSALQNMDRDALKKQIENMKYQASMERWPLSKSIAEMRSFIEENEKNDPLINAPDKKNNPWAEKGKCVIM
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. This subunit functions in visual transduction in the compound eye.
Q9NFZ3
C3K1P8
CHED_PSEFS
Probable chemoreceptor glutamine deamidase CheD
Pseudomonas
MKKPVGTTEVILAPGQVSFATRPTRLRTLLGSCVAITFWHPQRLIGGMCHFMLPGRLRKHQPLDGRYADEALELLLRHAQVNGTHARDYQVKLFGGGEMFPDLHRRLPTQDVASLNIRAALALAERYHLHLTAQDMGSTGYRTIMFDLWNGNVWVRHQPMGLLQEDAYQKNQCAGGR
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
C3K1P8
A3P027
HIS6_BURP0
ImGP synthase subunit HisF
pseudomallei group
MALAKRIIPCLDVTAGRVVKGVNFVELRDAGDPVEIARRYDAQGADELTFLDITATSDGRDLILPIIEAVASQVFIPLTVGGGVRAVEDVRRLLNAGADKVSMNSSAVANPPLVRDAADKYGSQCIVVAIDAKRVSADGEPPRWEVFTHGGRKGTGLDAVEWARKMAELGAGEILLTSMDRDGTKAGFDLALTRAVSDAVPVPVIASGGVGSLEHLAAGITEGHADAVLAASIFHYGEHTVGEAKRFMAERGIAVRL
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
A3P027
Q02ML8
CAS3_PSEAB
CRISPR-associated nuclease/helicase Cas3 subtype I-F/YPEST
Pseudomonas
MNILLVSQCEKRALSETRRILDQFAERRGERTWQTPITQAGLDTLRRLLKKSARRNTAVACHWIRGRDHSELLWIVGDASRFNAQGAVPTNRTCRDILRKEDENDWHSAEDIRLLTVMAALFHDIGKASQAFQAKLRNRGKPMADAYRHEWVSLRLFEAFVGPGSSDEDWLRRLADKRETGDAWLSQLARDDRQSAPPGPFQKSRLPPLAQAVGWLIVSHHRLPNGDHRGSASLARLPAPIQSQWCGARDADAKEKAACWQFPHGLPFASAHWRARTALCAQSMLERPGLLARGPALLHDSYVMHVSRLILMLADHHYSSLPADSRLGDPNFPLHANTDRDSGKLKQRLDEHLLGVALHSRKLAGTLPRLERQLPRLARHKGFTRRVEQPRFRWQDKAYDCAMACREQAMEHGFFGLNLASTGCGKTLANGRILYALADPQRGARFSIALGLRSLTLQTGQAYRERLGLGDDDLAILVGGSAARELFEKQQERLERSGSESAQELLAENSHVHFAGTLEDGPLREWLGRNSAGNRLLQAPILACTIDHLMPASESLRGGHQIAPLLRLMTSDLVLDEVDDFDIDDLPALSRLVHWAGLFGSRVLLSSATLPPALVQGLFEAYRSGREIFQRHRGAPGRATEIRCAWFDEFSSQSSAHGAVTSFSEAHATFVAQRLAKLEQLPPRRQAQLCTVHAAGEARPALCRELAGQMNTWMADLHRCHHTEHQGRRISFGLLRLANIEPLIELAQAILAQGAPEGLHVHLCVYHSRHPLLVRSAIERQLDELLKRSDDDAAALFARPTLAKALQASTERDHLFVVLASPVAEVGRDHDYDWAIVEPSSMRSIIQLAGRIRRHRSGFSGEANLYLLSRNIRSLEGQNPAFQRPGFETPDFPLDSHDLHDLLDPALLARIDASPRIVEPFPLFPRSRLVDLEHRRLRALMLADDPPSSLLGVPLWWQTPASLSGALQTSQPFRAGAKERCYALLPDEDDEERLHFSRYEEGTWSNQDNLLRNLDLTYGPRIQTWGTVNYREELVAMAGREDLDLRQCAMRYGEVRLRENTQGWSYHPYLGFKKYN
In this bacteria Y.pestis-subtype CRISPRs do not confer resistance to phage DSM3 or MP22, but instead are required for DMS3-dependent inhibition of biofilm formation and possibly motility.
Q02ML8
B6YS29
MRAY_AZOPC
UDP-MurNAc-pentapeptide phosphotransferase
Candidatus Azobacteroides
MLYSLFYFLSSLNVPGARLFRYISFRSVLSFSLSLIISVLIGERIIRFLQRHQAGETIRNLGLEGQIQKKGTPTMGGIIIIIAILIPVLLLARLSNIYVLLMLITTIWLGILGLIDDCIKVIWKHKEGLSGKIKIIAQVGLGLIVGLIVYLSPNIVMYENVEIRQQGGRKTVSYTPPLKSTQTTVPFFKNNNLDYRDLTAFMTNHRTAATWILFVLITVFIVTAVSNGANLTDGLDGLTAGSSAIIGVVLGILAYVSANLGFAAYLNIMYIPGCGELTVFASAFVGACMGFLWHNAFPAQVFMGDIGSLTLGGIIAVFAIIIHKELLLPMLCGIFFTESLSVMIQVAYFKYSKRKTGMGKRIFKMTPIHHHFQKGGSEEVNVIIQKPLNAIPESKIVVRFWLIGILLAALTVVTLKIR
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
B6YS29
Q8WV07
LTO1_HUMAN
Tumor-amplified and overexpressed sequence 1
Homo
MAGSQDIFDAIVMADERFHGEGYREGYEEGSSLGVMEGRQHGTLHGAKIGSEIGCYQGFAFAWKCLLHSCTTEKDSRKMKVLESLIGMIQKFPYDDPTYDKLHEDLDKIRGKFKQFCSLLNVQPDFKISAEGSGLSF
The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery . May be required for biogenesis of the large ribosomal subunit and initiation of translation . May play a role in the regulation of proline metabolism and ROS production .
Q8WV07
Q7WRB8
RL16_BORBR
50S ribosomal protein L16
Bordetella
MLQPSRRKYRKEQKGRNTGLASRGTHVSFGEFGLKATGRGRLTARQIEAARRAINRHIKRGGRIWIRIFPDKPISQKPAEVRMGNGKGNPEYWVAEIQPGKVLYEMEGVSEELAREAFRLAAAKLPISTTFVARHIGA
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q7WRB8
Q6LXB7
SECE_METMP
Protein transport protein Sec61 gamma subunit homolog
Methanococcus
MQKSKLNTTLNGLKDFLHQCRRVLMISRKPTRQEYITISKVTGLGICLLGFVGFVIHVPITYLKALIKP
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Q6LXB7
P10251
KAD_MYCCT
Adenylate monophosphate kinase
Mycoplasma
MNIMLLGAPGCGKGTQAEQLVNKLNFIQVSTGDLMRKEISLNTTLGLKCQEYMNAGKYVPDQIVNQIVNQFLQYNNDKLIFDGYPRTLEQAKSLEKMLDLYNKKIDYVFYIDVNEQILIKRITNRLVCPLCKASFNLETRKPKQEGLCDFDNTKLVKRSDDSLDKVKIRLQTYKEQTLPLIDYFKTNSKFIEIKADNLSAEQVFNQIKGELKI
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
P10251
P95200
NDHA_MYCTU
Type II NADH dehydrogenase NdhA
Mycobacterium tuberculosis complex
MTLSSGEPSAVGGRHRVVIIGSGFGGLNAAKALKRADVDITLISKTTTHLFQPLLYQVATGILSEGDIAPTTRLILRRQKNVRVLLGEVNAIDLKAQTVTSKLMDMTTVTPYDSLIVAAGAQQSYFGNDEFATFAPGMKTIDDALELRGRILGAFEAAEVSTDHAERERRLTFVVVGAGPTGVEVAGQIVELAERTLAGAFRTITPSECRVILLDAAPAVLPPMGPKLGLKAQRRLEKMDVEVQLNAMVTAVDYKGITIKEKDGGERRIECACKVWAAGVAASPLGKMIAEGSDGTEIDRAGRVIVEPDLTVKGHPNVFVVGDLMFVPGVPGVAQGAIQGARYATTVIKHMVKGNDDPANRKPFHYFNKGSMATISRHSAVAQVGKLEFAGYFAWLAWLVLHLVYLVGYRNRIAALFAWGISFMGRARGQMAITSQMIYARLVMTLMEQQAQGALAAAEQAEHAEQEAAG
Alternative, nonproton pumping NADH:quinone oxidoreductase that delivers electrons to the respiratory chain by oxidation of NADH and reduction of quinones.
P95200
Q8M9Y1
TILS_CHAGL
tRNA(Ile)-lysidine synthetase
Chaetosphaeridium
MNHFNLKLIKRIQNDLIKYNLLKPKKSILIAISGGQDSIVLLKILSILQIQWKWKLSIIYCDHQWNIYSKNQAFHLYKVSFQMGIPFYHGVTIKPLRTEKSARIWRYSVFQRIASISKFNVIVTAHSSTDRVETFLYNLFRGTGVQGLQSLTWKKNIQFEILPNFARSKKSFDLKILSLESKNGIQTYSDYNKLQLIRPLLNITRTELGKFCSNENLPLWPDLTNYNLSIIRNRIRYQTMPYLKIYFNCNLEKILAQIAEILYSENLYFENLSKKIMLKISFEEINSKKLSLSLFKILPLALQRRIIKFFFENHFSKILDFRDIEEIRYYILNLSNNSKFL
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Q8M9Y1
Q6NY82
UBE2F_DANRE
Ubiquitin-conjugating enzyme E2 F
Danio
MLTLASKLKREEGVRAGRTPAGSNDAAHRVSIRDRLLIKEVAELEANLPSTCKVTFPDENKLCHFQLAISPDEGYYLGGKFQFEIEVPEAYNMVPPKVKCLTRIWHPNIAETGEICLSLLREHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIDAAEHHLRDKEDFRNKVQDFIKNYAR
Accepts the ubiquitin-like protein NEDD8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase rbx2, but not rbx1, suggests that the rbx2-ube2f complex neddylates specific target proteins, such as cul5.
Q6NY82
B2I6G9
NAGZ_XYLF2
N-acetyl-beta-glucosaminidase
Xylella
MLLIGVAGTTLSAQEVDWLQDDAVAGVVLFKRNFASRAQIVELSAALREAAPRPLLLAVDQEGGRVQRFHEGYSALPPLQGIGALYVRDPEAALELAFEHAWLMASEVRASGVDLSFAPVVDLGRGNRAIGDRAFSDDPHVVAAFAKAYVQGMHAAGMPVTLKHFPGHGSVLEDTHVDLAVDVRALETLESEDLVPFAAGIAAGADAVMMAHVVYPNVAPEPAGFSAHWIEVILRGRMGFRGVVFSDDIGMAAVRGVGGVVGCVHAHLDAGCDVVLVCHPELVNDALSAVAGRRSNTAALIGLIGRGVLGWDGLLADVRYGSIQSHLFERFGTST
Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.
B2I6G9
Q7CNU3
OMP2A_BRUME
Porin Omp2a
Brucella
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYSGTDRNGWDKGARFALMFNTNSETELGTLGTYTQLRFNYTSNNSRHDGQYGDFSDDRDVADGGVSTGTDLQFAYITLGGFKVGIDESEFHTFTGYLGDVINDDVVAAGSYRTGKIAYTFTGGNGFSAVIALEQGGEDVDNDYTIDGYMPHVVGGLKYAGGWGSIAGVVAYDSVIEEWATKVRGDVNITDRFSVWLQGAYSSAATPNQNYGQWGGDWAVWGGAKFIAPEKATFNLQAAHDDWGKTAVTANVAYQLVPGFTITPEVSYTKFGGEWKDTVAEDNAWGGIVRFQRSF
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
Q7CNU3
E0SHN8
LPOB_DICD3
Penicillin-binding protein activator LpoB
Dickeya
MKKYLGIVLMALVIAGCTSRVPQTEQPATIEPAVPTPSKPQLPPSESQPLPTPPKIQVPVLDWSAAVTPLVGQMVKTDGIARGSILLLNKLKNNTNGSLQTAQATTALYNALASSGQFTMVSREQLGVARQSLGLSEEDSLESRSKAVGLARYVGAQYVLYADASGDVKSPELSMQLMLVQTGEIVWSGNGTVRQQ
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
E0SHN8
Q74JK1
RNH2_LACJO
Ribonuclease HII
Lactobacillus
MTITEIKNLLQGEVSKEQLEELKADERKGVQKLLISYEKRQAKYAKALAQFQSRFSYEKEFWQKDQLVAGVDEVGRGPLAGPVVTAAVILPHDFDLIDVNDSKKLSPKKRQALFPKILEKAVSVSVGLANNDVIDQINIYEADRLAMAHAVQGLKVKPDALLVDAMNVPLNIPQVKLIHGDAKSNSIAAASIVAKVFRDNLMDAYGELYPEYDFKHNAGYGTREHMEALEKYGPTPIHRRSFAPVSEYEK
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q74JK1
Q09768
GSH1_SCHPO
Gamma-glutamylcysteine synthetase
Schizosaccharomyces
MGLLVLGTPLDWPESKKYCDYVRENGIMQFLHMYDTYISKKQDVLLWGDEIECIVVSMDDKSKKARVSLRQEDILNALGKYEETFRHVDFGPVYAALRNETCPKKIDAILSEVAKNPADYVERIGGNSNKDTIEITSSTKPHAQNAVPTFHPEYGRYMLESTPGAPYGSTLKDFTFVEYNMRLRRKIIENHLLPNELPLTITNFFRLGTPGFTDPEVEANGAISRSFFLPDDVINTHVRFPTLTANIRQRRGRKVAMNVPIFFDKNTIKPFHDPTVPWDRNLFPEDANARDGAALDNHIYMDSMGFGMGCCCLQITFQAKSCDEARLLYDQLTPITPLMLALSAGTPAFRGYLADQDCRWNVIAGAVDDRTEEEMKTVPKSRYDSVDLYISNDKRNLPEYNDVPVVINQDCYDKLIKDCIDERLAKHMAHIFSRDPLVIFSDSILQDNSVSNAHFENLNSTNWQSMRFKPPPPGSDIGWRVEFRSMEIQITDFENAAYSIFVVMLSRAILSFNLNLYMPISLVDENMKAAHARDAIHRKKFWFRCNPFPDASTDDESGQFRQLTIDELFNGEHRENGFPGLITIVRSYLYSCNPDAKTICLIERYIRLISQRANGQCLTAASWIRNFITTHPSYKQDSVVNDEINYDLIRRIAKIVDGDYDDTLLGKCS
Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
Q09768
A5EKQ4
YQGF_BRASB
Putative pre-16S rRNA nuclease
unclassified Bradyrhizobium
MPAPILPLIEAASRWPERGALVGLDLGTKTIGVAVSDPDRRLATGVETIQRKAFKADAARLLAISSERKVVGFVLGLPINMDGSEGPRAQSTRAFARNLANLTDLPIGLWDERLSTAAVERELIGMDVSRARRAEVIDTHAAIFILQGALDRLATLRRSGQ
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
A5EKQ4
A8CG89
PA2B1_DABRR
Phosphatidylcholine 2-acylhydrolase
Daboia
MRTLWIVAMCLIGVEGNLFQFARMIDAKQEAFSFFKYISYGCYCGWGGQGTPKDASDRCCFVHDCCYARVKGCNPKLVEYSYSYRTGKIVCETYNRCKRAVCECDRVAAICLGQNVNTYNKGYMFLSSYYCRQKSEQC
Exhibits high hydrolytic activities and shows strong preference for the anionic micelles (dPPC with deoxycholate) to the zwitterionic micelles (dPPC with Triton X-100). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
A8CG89
Q3IGW5
SUCC_PSET1
Succinyl-CoA synthetase subunit beta
Pseudoalteromonas
MNLHEYQAKQLFAEYGLPVSTGYACDTPEEAAAAAEKIGGDMWVVKTQVHAGGRGKAGGVKLVKTIDEVKAFAANWLGKNLVTYQTDEKGQPVAKILVESCTDIANELYLGAVVDRASRKVVFMASTEGGVEIETVAEETPELIHKAEIDPLVGPQAYQARELGFKLGLNPVQMKQFVKIFMGLGKMFTDFDFALLEINPLVITDEGNLHCLDGKIGIDGNALYRQPKIREFHDPSQEDSREAHAASFELNYVALDGNVGCMVNGAGLAMGTMDIVNLHGGKPANFLDVGGGATKERVSEAFKIILSDDNVKAVLVNIFGGIVRCDMIAEGIIGAVKEVGVNVPVVVRLEGTNAELGREVLKNSGLDIIAAESLTDAAEKVVAAAEGK
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Q3IGW5
B4RBP5
BIOB_PHEZH
Biotin synthase
Phenylobacterium
MNAHVRPVDPANVDPAQPRHDWTLEEVEALFELPFTELVFRAAEVHRRWFDPTELQLSQLLSVKTGGCPEDCGYCAQSQKFKTGLAASKLMEAETVIAAAAEAKAGGAQRFCMGAAWRDLKDRDLPKVAAMISGVKALGLETCATLGMLTADQAKALKAAGLDYYNHNLDTGPDYYDKVVTTRTYQDRLDTLAAVRDAGMATCCGGIVGMGETRRDRAGLLHQLATLPAHPDSLPINDLMPIPGTPLGDSKAVDPLEFVRMIAVARIVCPKSMVRIAAGREHMTKELQALCFLAGANSIFVGARLLTTDNPEKTADEALLADLKMKPMAMA
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
B4RBP5
Q40611
ATPA_OCHNE
F-ATPase subunit alpha
Ochrosphaera
MINIRPDEISNIIRQQIESYDQEVQIDNVGTVLQVGDGIARVYGLEQVMAGELLEFEDKTVGIALNLENDNVGVVLMGPGLDILEGGSVRSTGKIAQIPVGDGFLGRVVDSLARPIDGKGDIDATESRLVESMAPGIITRKSVCEPVQTGITAIDSMIPIGRGQRELIIGDRQTGKTSVAIDTIINQKSEDVICVYVAIGQKASSVASIVTTLEEKGALGYTIVVASNADDPATLQYIAPYTGAALAEYFMYKGKATLIIYDDLSKQASAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDALGGGSMTALPIIETQAGDVSAYIPTNVISITDGQIFLSGDLFNAGIRPAINVGISVSRVGSAAQTKAMKQVAGKLKLELAQFAELEAFSQFASDLDAATQAELARGQRLREMLKQPQNSPIPVEEQVALI
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Q40611
Q5NPY8
AROB_ZYMMO
3-dehydroquinate synthase
Zymomonas
MSSEVSKTVTVPIDLGNHSYKIDIGAGLYQQAVSILTPYVRNRRFIVITDENVARCQLPEFEKSFHEAGVTVDSIILPAGEATKSWHHLAELCDQLIRRGVERRDAIIALGGGVIGDLVGFAAAILKRGCQFIQIPTSLLAQVDSSVGGKTAINCEAGKNLIGAFHQPVFVLIDPDALQTLPARQLRAGYGEIIKYGLIDDPDFFAWCEEHGAALIEGDKASRLYAIEHSIRAKALIVADDEKEISGKRALLNLGHTFGHALEADTGFSDKLFHGEAVAAGSALAFGFSYVKNLASKEDIQRIIKHLRETGLPASLEEAGVKASGKELVAHMMHDKKMEAGRLPFLLARGIGKSFLDKEVNLEEIAAFLDSPLARKGTI
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Q5NPY8
B1AXV0
FRS1L_MOUSE
Ferric-chelate reductase 1-like protein
Mus
MAGQPLRRPAWVPLLLRLLLAGIAACDASPADDSAGPGGRGPRGRARGDAGADEAVPRHDSSYGTFASEFYDLRYLSEEGYPFPTAPPVDPFAKIKVEDCGRTKGCFRYGKPGCNAETCDYFLSYRMIGADVEFELSADTDGWVAVGFSSDKKMGGDDVMACVHDDNGRVRIQHFYNVGQWAKEVQRNPARDEEGVFENNRVTCRFKRPVNVPRDETIVDLHLSWYYLFAWGPAIQGAITRHDIDSPPASERVVSIYKYEDIFMPSAAYQTFSSPFCLLLIVALTFYLLMGTP
Important modulator of glutamate signaling pathway.
B1AXV0