accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q87S09
EX7L_VIBPA
Exodeoxyribonuclease VII large subunit
Vibrio
MLSKTNQNIFTVSRLNAEVRLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSRAQVKCAMFRGNNRRVTFKPANGNQVLVKARLSLYEPRGDYQLIIESMQPEGDGRLQQEFEELKMKLAAEGLFAQTNKLPLPEHPKRVGIITSKTGAALYDILDVLKRRDPSLPVVIYPTMVQGDDAAIQIAQAIGRANSRNECDVLIVGRGGGSLEDLWCFNNEILARTIAASQIPIISAVGHEVDMTIADFVADVRAPTPSAAAELVSRDNSHKDQSLVAKQHKLASAMRYYLSQQKQQSAQLLHRLERQHPSYQLQRQSQQLDELDMRLRRAMQRFIDTRQQAVERKHHRLQLNSPVKHLAQQKSRLERVEHKLLDTMDRKLLTMRHQLAIAAEKLDTVSPLATLKRGYSITQTEQGKVVTSADDVKTGDLLVTRLANGEIHSTVS
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Q87S09
P47987
PLLP_RAT
Plasma membrane proteolipid
Rattus
MAEFPSKVSTRTSSPAQGVGASVSAMRPDLGFVRSALGVLALLQLVLGLLVWALIADTPYHLYPAYGWVMFVAVFLWLVTIVFFIIYLFQLHMKLYMVPWPLVLLVFFVAATVLYITAFVACAAAVDLTSLRGSRPYNQRSAASFFACLVMIAYGLSAFFSFQAWRGVGSNAATSQMAGGYS
Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective.
P47987
Q9YGK5
COLI2_CYPCA
Met-enkephalin
Cyprinus
MVRGVRMLCPAWLLALAVLCAGGSEVRAQCWEDARCRDLTTDENILNCIQLCRSDLTDETPVYPGESHLQPPSELEQAEVLEPLSPAALAPAEQMDPESSPRHELKRSYSMEHFRWGKPVGRKRRPIKVYTNGVEEESAESLPAEMRRELATNEVNHPQEDSALIQQKKKDGSYKMKHFRWSSPPAGKRYGGFMKSWDERSQKPLLTLFKNVINKEHQKKDQ
Endogenous opiate.
Q9YGK5
A5FIY0
MRAY_FLAJ1
UDP-MurNAc-pentapeptide phosphotransferase
Flavobacterium
MLYYLFEYFDKTLDVPGTGVFQYITFRSALAFMLSLLLSTIYGKRVINFLRRQQVGETVRELGLAGQNEKAGTPTMGGLIIIFATLVPVFLFARLHNIYIVLLIVTTLWMGTIGFVDDYIKIFKKDKQGLKGIFKVIGQVGLGIIVGAVLYFNPAVTVRTDTGKTDVFKTAANTTVVLPAPVEEKSTATTIPFVKNNEFDYAEVLSFMGDGYEKWAWLVFIPVVIFIITAVSNGANLTDGIDGLAAGTSAVSVLALGIFTFVSGNIIFSNYLNIMYIPNSGEMTVFISAFVGALIGFLWYNSFPASVFMGDTGSLTIGGIIAVLAIAVRKEILIVLFCGIFLAESASVIIQVTYFKYTKKRFGEGRRIFLMSPLHHHYQKKGYHESKIVTRFWIVAVMLAILSIVTLKLR
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
A5FIY0
A9MXG7
WECG_SALPB
UDP-N-acetyl-D-mannosaminuronic acid transferase
Salmonella
MTNNAAAPLYSLRGLPLIGWRDMSHALNYLFADGQLKQGTLVAINAEKLLTAEDNPEVRALIAAAEFKYADGISVVRSIRKKFPQAQVSRVAGADLWEALMARAGKEGTPVFLVGGKPEVLAQTEAKLRTQWNVNIVGSQDGYFTPEQRQALFARIHASGAKIVTVAMGSPKQELLMRDCREVHPHALYMGVGGTYDVFTGHVKRAPKIWQNLGLEWLYRLLSQPRRITRQMRLLRYLRWHYTGDL
Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.
A9MXG7
B0UMS9
PROA_METS4
Glutamyl-gamma-semialdehyde dehydrogenase
Methylobacterium
MSVLSLKPRAGADDVDALMREIGRRARAASRRMALVPARAKDMALRAAAAAIRDAAPVILEANAADLAEARGANLPAATLDRLALTPGRVEAIAAAVEAIAGLPDPVGRQLAAFERPNGLAIERISTPLGVVGVIYESRPNVTADAGALCLKAGNAAVLRAGSESLRSAAAIARAMADGLAAQGLPAEAIQLVPTRDRAAVGAMLAGLDGCIDVIVPRGGKSLVARVQSEARVPVFAHLEGICHVFVHARADLAMAREILRNSKLRRTGICGAAETLLVDRACAGTHLAPLVADLLEAGCAVRGDAETQAVDPRVTPATEADWRTEYLDAVIAVRVVDGLDAAIDHVETYGSHHTDAIVTADEAAAERFLAEVDSAIVVHNASTQFADGGEFGFGAEIGIATGRMHARGPVGVEQLTTFKYRVHGSGQVRP
Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
B0UMS9
Q9PU47
PDLI3_CHICK
Alpha-actinin-associated LIM protein
Gallus
MPQNVILPGPAPWGFRLSGGIDFNQPLIITRITPGSKASTANLCPGDIIVAINGLSTENMTHNDAQERIKAAAHQLSLRIERAETKLWSPQVSEDGKANPYKINLEAEPQEFKPIGTAHNRRAQPFVAAANIDDKRQVVSSSYNSPIGLYSSGNIQDALHGQLRSLIPNASQNDPAPAAVPQSDVYRMLHSNQEEPSQPRQSGSFKVLQNLVSEEDGRPVGTRSVKAPVTKIPTGLPGAQKVPQCDKCGSGILGTVVKARDKYRHPECFVCSDCNLNLKQKGYFFVEGQLYCEAHARARMRPPEGYEAVTVYPKC
May play a role in the organization of actin filament arrays within muscle cells.
Q9PU47
B8GBH2
FABZ_CHLAD
Beta-hydroxyacyl-ACP dehydratase
Chloroflexus
MLSIQEIMALIPHRYPFLLVDRIVELEPGVRAVGEKLVSANEPYFQGHFPGNPIMPGVLILEALAQTGAVAALSLPEHAGKLVLFAGIDGARFKRVVRPGDTLRLEVQLERMRRGIGKGQARATVADQLACEAELLFAVTDPTK
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
B8GBH2
Q3J474
DTD_CERS4
Gly-tRNA(Ala) deacylase
Cereibacter
MRALIQRVSEASVTVEGELLGEIGPGLLILVCAMQGDGEAQASALAARIAKLRIFRDEAGKMNRSVRDTGGAALVVSQFTLAADTSRGNRPGFSAAAPPADGERLYRHFAAEIAACGIPTATGRFGADMKVRLLNDGPVTIWMET
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
Q3J474
A0A2K9RFZ8
TPS3_VITAC
Terpene synthase 3
Vitex
MCSLSTLSPNFSNAYGSKSVSSTASRFPCWQRSNETWKTQSREVIHWTYVVRCKEVLNEARQGHMNLPHVTLQNDLCEREALKEDMPLLNEYKMEECIRYIKNMLGSMDDGRITVSPYDTAWIALIRDIEGRDIPQFPSSLEWIANNQLSDGSWGDEQFFLAYDRLLNTLACVVALTYWKVHADKSEKGILFIKENISKLGDANVEQMTCGFEVVFPALLTKAKDLGIHGIPYDAPVMQEIFATKDRKMERVPKELLHKVPTCLLHNLEGLGNVDALGKLDWPKLLKLQTPKGSYITSPAASAFAVMETKDKDCLAFINYVVNKFNGGAPTVYPVDIYARLWAVDRLQRLGISRFFEPEIKNCLDYVYRFWTEKGVFSARESEFCDIDDTSMSIRLLRLHGYDIKPNALKHFKKDNMFTCYVGQGFESPSPIFNLYRASQVLFPGETILEEARDFSYNFLRERLEKNDLLDKWLISKHLPDEIKCGLEMPWYASLPRVEARFYIENYGVDDIWIGKSLYRMPEINDPVYLELAKLDYKRCQTQHQLEWRHIQQWYEDSSLEEFGISKKDLLLAYFLAAASIFEPGRSGQRLAWVKSQIMSHILTTYFSIKEASSSEQRKSSTKLENEQGRGQSRKTTIQRFITIFFGSLQEIMRDANEQIGKDISNLLFDIWRVWLEKLGEGNEEIQEVELLVSTINICGGHIASKDILSHSEYKTLSRLTNKICHQLRQLDMGNEELIAIEWRKNKTTDSIYREIEKDMQLLVQLVLQDSSNGISKDIKQTFLLAAKTFYYRAYFPTEQIGNHISKVLFEPVV
Involved in the biosynthesis of labdane-type diterpenoid including cleroda-dienols, and peregrinol lactones and furan derivatives, dopaminergic diterpenoids that can bind to dopamine receptors in the human pituitary gland, have probably ability to lower prolactin levels, and are used to treat menstrual cycle disorders (e.g. premenstrual syndrome and mastodynia) (Probable). Terpene synthase that produces syn-copalyl diphosophate from geranylgeranyl diphosphate (GGPP) .
A0A2K9RFZ8
C5D5M0
LEU1_GEOSW
Alpha-isopropylmalate synthase
unclassified Geobacillus
MRKINIFDTTLRDGEQSAGINLNLQEKLEIARQLERLGVDIIEAGFPASSKGDFQAVKQIAETIKTCSVTGLARSVQSDIDAAWEALKGGAEPRLHLFIATSPIHMKYKLQMTPEQVIETAVESVKYAKRYFPIVQWSAEDACRSELPFLAKIITEVIKAGATVINIPDTVGYITPKEYGNIFTFLSNNVPNIEKVSLSAHCHDDLGMAVANSLAAIEHGATQIEGTINGIGERAGNAALEEIAVALYIRKDYYQAETRLNLQEIKRTSNLVSKLTGVVIPPNKAVIGKNAFAHESGIHQDGVLKEKTTYEIISPELVGVQSNSMVLGKHSGRHALRNRVEELGYTLSDEEVNKLFVRFKELADKKKDITDDDLVALIFEEKFDHFKDFYQLSSLQVQYGTNQIPTAVVVLKDGQGNEIQEAATGAGSVEALYNTLERCFKTSVTLLDYRIESVSGGRDALAQVFVKVRVNDIETSGRGTAQDVLEASAKAYINAVNRVFMIETMRAENQKVAMQ
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
C5D5M0
P45606
PHOB_SHIDY
Phosphate regulon transcriptional regulatory protein PhoB
Shigella
MARRILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIPVVMLTARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRISPMAVEEVIEMQGLSLDPTSHRVMTGEEPLEMGPTEFKLLHFFMTHPERVYSREQLLNHVWGTNVYVEDRTVDVHIRRLRKALEPGGHDRMVQTVRGTGYRFSTRF
This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
P45606
C3P8W4
TATA_BACAA
Sec-independent protein translocase protein TatA
Bacillus cereus group
MFSNIGFPGLILILVAVLILFGPKKLPEIGKALGETLKEFKKSTKELTDDAFQEKEKKEKM
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
C3P8W4
Q7VL12
BIOD2_HAEDU
Dethiobiotin synthase 2
Haemophilus
MGKIIFVSGIDTDIGKTIATGFYAKRLMQQGFSVITQKMIQTGCQHISADIIKHRQLQGIELTAEDLNGITCPYLFRYPCSPHLAAEMENNPILPSKIAQASALLAQKYDYVLLEGAGGLAVPYNSQQTTLDYIVEQQLPLILVTSAKLGSINHTLLSLIVCQQHKIEMEAVIYNTYPLEDEKIAKSTQLYLQQYIKQHFPNTEFLVMDRQ
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Q7VL12
A9GXK6
RS18_SORC5
30S ribosomal protein S18
Sorangium
MNGRNNDMGRNGGADYDDRDFGRTPDLNADAPGRRRTGRKRVCRYCADKALVIDYKDPQALKYFISERGKVVPRRISGNCARHQRKVTLSIKRARNIALLPFTVTA
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
A9GXK6
Q1QL43
DAPA_NITHX
4-hydroxy-tetrahydrodipicolinate synthase
Nitrobacter
MASKTKFRGSYTALVTPFKNGSVDEAAFRSLVSWQIGEGVHGLVPVGTTGESPTLSHDEHRKVVEWCIDEARGRVPVIAGAGSNSTREAVDLAVHAEKAGADAVLVVTPYYNKPTQEGMYHHFKTVNDAIGIPIIIYNIPSRSVVDLSVETMARLFELKNIAGVKDATANVARVSLQRHAMGPDFIQLSGEDMTALAFMAAGGHGCVSVVANVAPKLCASLMSAVLKGDYATGLAIQDRLVPLHAAIFKEPGLAGAKHGLKLLGRLDEVVRLPLLPVTPPTGKVIRDAMVHAGLLN
Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
Q1QL43
Q3Z1P4
SAFA_SHISS
Two-component-system connector protein SafA
Shigella
MYATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINSLQD
Connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions.
Q3Z1P4
Q49KZ2
ATPE_EUCGG
F-ATPase epsilon subunit
Eucalyptus
MTLNLCVLTPNRIVWDSEVKEIILSTNTGQIGVLPNHAPIATAVDIGILRIRLNDQWLTMALMGGFARIGNNEITILVNDAEKGSDIDPQEAQETLELAEANLRKAEGKRQTIEANLALRRARTRVEAINAIS
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q49KZ2
B3QBW6
RS8_RHOPT
30S ribosomal protein S8
Rhodopseudomonas
MSTHDPISDLITRIRNAQMRSKSKVSTPGSKMRANVLDVLKAEGYIRGYATVEHPSGRSELEIELKYFDGEPVIREIERVSRPGRRVYASVKNLPRVNNGLGISVLSTPKGIMADHDARDANVGGEVLFTVF
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
B3QBW6
A0LPG9
ISPE_SYNFM
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Syntrophobacter
MRGIRKGHALALRVGTPAKINLWLEIVRKREDGYHDLSSLMLPVAVYDHVEVAWSHEGGVRLSCDSAEVPDDRGNLAWRAADAYLEAAGVTRGVSIRLEKNIPVGAGMGGGSSDAAAVLLALNRLSENPLSEAVLHRLAVGLGADVPFFLHCVPALATGIGERLLPVHGIPDYPLLLVKPPISVSTGWVYGSLKLTRGESRIKLRSFLDRPWHLSEVLRNDLETVTLNEYPQLGQIKCWLMENGAVGSLMSGSGPTVFGVFAEQRLADGAGELARRVWKDCRVDVTRVLGTPVSARS
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
A0LPG9
Q66KJ9
MET14_XENTR
Methyltransferase-like protein 14
Silurana
MNSRLQEIRARQTLRRKLLAQQLGAESADSIGAVLNSKDEQREIAETRETSRASYDTSATVSKRKMPEEGEADEEVIEECKDAVEPQKEEENLPYREEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELISKSNTPPMYLQADLESFDLRELKSEFDVILLEPPLEEYFRETGIAANEKWWTWEDIMKLDIEGIAGSRAFVFLWCGSGEGLDFGRMCLRKWGFRRSEDICWIKTNKDNPGKTKTLDPKAIFQRTKEHCLMGIKGTVHRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNFNSETYASYFNTPNSPLTGCTEEIERLRPKTPPPKSDRGFGASRGGGRGGPSAGRGERGRERNRGSFRGDRGNFRGRGGPHRGVFAPR
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with mettl3, mettl14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing.
Q66KJ9
C4YH38
IRC6_CANAW
Increased recombination centers protein 6
Candida
MIPNHILILGSPNSGKLRIANLISKNEEIPNLEDVELHSGLIVKASLRTKYYFLKLNILIDEYSESKGATDEKKLSELHKWYQEFKSEEFGELREVLDGLMFTINMKTDSISFIRDALEIIEQIKISLGDEENLHDWGGFIAVVGSCPENQIVEDDLILEIEDMVLSQGLEFINLSTEGENEYKEKQGKDRIVELIESHDWTNLEMLKVDSKQYETNKLAKMESMKQKLINEKEELDLDDIFSKLNLARDHAQSLTQDERDKYANKVIEEIIDFL
Involved in gross chromosomal rearrangements (GCRs) and telomere healing.
C4YH38
B9MBT7
GLPK_ACIET
Glycerokinase
Diaphorobacter
MTYLLALDQGTSSSRSIVFDERGRIVAQAQRELPQIYPRPGWVEHDPREIWRTQLATAQDALREARITAQDVRALGITNQRETTVLWNRRTGQPVHHAIVWQDRRAEPACAQLREQGHAAAIQAKTGLLIDAYFSGTKLQWLLDHVPGARDAAEAGELAFGTVDSWLIWQLTGGTRHVTDVSNASRTMLFNVHTNQWDDELLQLLRIPRALMPEVLPSASDFGATDAALLGGPIAIGGVAGDQQSALFGQACFTAGMAKNTYGTGCFMLMHTGSRFQKSENGLLTTSAAQASRSPEYAMEGSVFVGGAVVQWLRDGLRAISASSEVQALAESVPDSGGVMMVPAFTGLGAPYWKPDARGTITGLTRGTTIAHIARAALESIAYQSAALLAAMSRDAVAAGGAPVSELRVDGGACVNDLLMQFQADLLGIPVVRPAVVETTALGAAYLAGLASGVYASTDELSALWQAERRFTPTLPRSQAEALMARWEHAVAQAVLPG
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
B9MBT7
Q96376
LIS_CLABR
S-linalool synthase
Clarkia
MQLITNFSSSSSELQFLVDKVKRESLSSSSSNTQNLFLSTSPYDTAWLALIPHPHHHHHHGRPMFEKCLQWILHNQTPQGFWAAAGDNISDTDDDVTLDCLLSTLACLVALKRWQLAPDMIHKGLEFVNRNTERLVMKQKPSDVPRWFTIMFPAMLELAGASSLRVDFSENLNRILVELSQNRDDILTREEVDEKKQYSPLLLFLEALPAQSYDNDVLKQIIDKNLSNDGSLLQSPSATARAYMITGNTRCLSYLHSLTNSCSNGGVPSFYPVDDDLHDLVMVNQLTRSGLTEHLIPEIDHLLLKVQKNYKYKKASPKSLYSIAAELYRDSLAFWLLRVNNHWVSPSIFCWFLDDDEIRDHIETNYEEFAAVLLNVYRATDLMFSGEVQLVEARSFATKNLEKILATGNIHKTNADISSSLHKMIEHELRVPWTARMDHVENRIWIEEIASSALWFGKSSYLRLSCFHKMSLQQLAVKNYTLRQLVYRDELAEVERWSKERGLCDMGFCREKTGYCYYAFAASTCLPWSSDVRLVLTKAAVVITVADDFFDVEGSMVDLEKLTDAVRRWDAEGLGSHSKTIFEALDDLVNEVRLKCFQQNGQDIKNNLQQLWYETFHSWLMEAKWGKGLTSKPSVDVYLGNAMTSIAAHTMVLTASCLLGPGFPVHQLWSQRRHQDITSLLMVLTRLLNDIQSYLKEEDEGKINYVWMYMIENNQASIDDSVRHVQTIINVKKQEFIQRVLSDQHCNLPKSFKQLHFSCLKVFNMFFNSSNIFDTDTDLLLDIHEAFVSPPQVPKFKPHIKPPHQLPATLQPPHQPQQIMVNKKKVEMVYKSYHHPFKVFTLQKKQSSGHGTMNPRASILAGPNIKLCFS
Involved in the biosynthesis of the acyclic monoterpene S-linalool, a major component of the strong sweet scent of the C.breweri flowers.
Q96376
Q6B8R6
RPOC2_GRATL
Plastid-encoded RNA polymerase subunit beta''
Agarophyton tenuistipitatum
MTQDKSIEPFFLNKVVDKSQLRQLIIWAFRNYGIARASNMADTLKDLGFLYATKAGISLSLEDLRIPPAKNNLLKTTIDLINDTDTKYRKGEITAVERFQKVIDTWNSASDTLKKQVIKYFTEKDPLNSIYMMAFSGARANISQVRQLVGMRGLMADPQGQIIDLPISSNFREGLTITDYFISSYGARKGLVDTALRTADSGYLTRRLVDVAQDVIIREADCNTSKGIVLESMIDNRKTLVSLHQALIGRVLAEDLFNPAGSKLVAKLNTEISPDLANEIISLGISSVLVRSPITCESIKSVCQSCYGWNLAHGRIVDLGEAVGIIAAQSIGEPGTQLTMRTFHTGGVFTGELAQTVISSSDCQVEYPSNIILSDTRTRHGDHAFLVEKDIKLKLLDFNKKQTSLSLVKGSLLFVKHLEYITSGQVIAEYPISNRLITEKAQKAVLADFSGSIYLMDLSVSNIQSEQQTFKNVIKGGVIWILAGHVFSIPYNTQLIISENDFIDENHLIGKTEFVSRYEGRVRILKKKQDFIQDIVIITSSKTYINIDVLTKFYNGYTNHFLITNQQDKFILKTLPNQTIVDQQLIAELITNIYRTNTGGIIKYLDLSVSDKKVDLNSKKDYYDIVDGGYVLWIGEETHEINKDISLLLVSHGQLIDEGTEIVKNIFTNSSGIVDIIQKEGIVREIIIKPGILYPHSKFYDHKSKSRGFLKPGEIISNDLKTDKLVYWEYFYVKNQSYTLIRPVIVYSIPSKTIQFKYSADSFNSHICSLKLVKRIYFRDGERVKSVSGIDIVKTYLIAELNKDSLNLKCTLQLNLDSNNRSISRMRIVTMDKLSLKDENNIASTKDLYTRTRLLVTNNQYIKSGTVVAQTELFSSLEGQVVSIQKNKSSNPRILLITSLDTKVFSINNNQNIKVNINDLIYAGDEIATNIISYISGQVISIRDNQITVRLGQPYLISEGSFLHVNNQALIQRGENIATLIFERVKTGDIVQGLPRIEEILEARKKSDSFFNPHVVLDSKFRQYVNQGLNLYDATRLSLLILQLYLVKELQLVYQSQGVEIADKHIEVIVRQMTSKVKIENGGDTDHLPGEIIELQKIEMLNKALRLASKEEALYYPILLGITKASLNTESFISAASFQETTKVLTDAAISCKLDWLRGLKENVIIGRLIPAGTGFNIYNNMQLNYQDEKYSYTKNLLSLPQNTKNLNFEDIIVDDRNAHMYSRNNNL
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q6B8R6
P33739
MS2B_DROSE
Male accessory gland secretory protein 355B
Sophophora
MNYFAVLCIFSCICLWQFSDAAPFISVQSSSQSRSQKVMNGMLRTLYDYSVQDSVNDATGHLIHTHKSNFNSDVMSPEEIERVRQQLNMA
This protein is transferred from male to female during mating and may affect egglaying and behavior after mating.
P33739
A8F7A0
MINC_PSELT
Probable septum site-determining protein MinC
Pseudothermotoga
MTIDLIDFKMTKEGLVLVIKDYDNLEDVVNQLTSKISQMSGFFAAGDKIMLMIENNEKHSHDMPRIISILKKMGIEVSQILMGVTAKEGINVRGRMKMVEEGETKSGTKVVKKNLRSGQALVHSGDVIVIGNVHSGAEIMAGGSIVVFGNVKGILRAGLNESDSIVAALSMEPSLIQISEYILREAGSYDEPVVVHVKQNKIVIESAKDVKFQ
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
A8F7A0
A1WVM7
BIOB_HALHL
Biotin synthase
Halorhodospira
MTETDTWHWDQPQIHALFELPLPELLFRAQEVHRRHFNPGQVQACTLVSIKTGACAEDCTYCSQSARYDTGLEREALIDVETVREAAQRARASGATRLCMGAAWRGPKDRDLETLVAMVRAVKAEGLEACLSAGLLAEGQAERLAEAGLDYFNHNLDTSPSYYDQVVTTRSYEQRLQTLERIRDAGMRVCCGGIVGLGEARADRVEMLATLANLPVPPQSVPINRLIPIPGTPLEAAEPVDPFEIVRTIAATRLVLPRSYVRLAAGREQMSDELQALCLSAGANSLFLGERLLTTDNPDADADHRLLHRLGMTLEPRTHSCAELEP
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
A1WVM7
Q28934
IAPP_SAGOE
Amylin
Saguinus
NTATCSMHRLADFLGRSSNNFGAILSPTNVGS
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Q28934
A0RUZ0
EF1B_CENSY
aEF-1beta
Cenarchaeum
MAQLLVIVKILPKGTEVDLDEMMEGLKGGLKGGIVLRRYAKEPLAFGLHFVKAEFILEDKEGQNDALEATVRSAKGVSEYEVLNMSRMSVDMK
Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.
A0RUZ0
Q9HS17
GLCDH_HALSA
Glucose 1-dehydrogenase
Halobacterium
MDAIVVSKADRTPRLVDRPRPDPTPGSVLVRTLRVGVDGTDHEVIAGTHGGFPEDADELVLGHEAIGVVADPTDTRFSAGQLVAPTVRRPRGDPTPQFDRGQPDMAAPGTYVERGIDGADGFMADYFTSPADALVALPDSLAAHGFLTEPVSVAEKAIELALASRSAFDWRPDSALVLGNGSLGLLTLAILAARDDTETLYCLGRRSRPDPTIDIIERLGATYIDSRTTPVADIPAAHQPVDMVYEATGHAKHAFDAIDALAPAGVAALLGVPAAGWTFEVPGSDLHRSLVLENKAVVGSVNSNARHFRAAADTLAALPDWLCDAIVTGVHDTAAFADAFRDGETSIKTAVQFDTR
Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a modified Entner-Doudoroff pathway.
Q9HS17
Q5ZT08
TSAD_LEGPH
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Legionella
MLVLGIESSCDETGVAVYDSESGLLSHALHSQIATHRVHGGVVPELASRDHVNYLVPLVDEVLTKAQIRKNQLDGIAYTAGPGLIGALLVGSCFAKSLAYALNIPALAIHHLEAHLLAAKMETPSLDFPFIALLVSGGHCQLIEVNNIGEYRLLGDTLDDAVGEAFDKTAKLMGIPYPGGAVLANLADQCLSTPYQFPRPMTDRPGLDFSFSGLKTHALNTWNQSEKKESDRSEIAKAFQQAVVETLIIKCKRAIKESQSKRLVVAGGVGANKALRSALQKWIKDIQGEVYFPALEYCTDNGAMVAYAGCLRMMRGEIDGGLGVIVKPRWPLA
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Q5ZT08
Q38X21
PYRF_LATSS
OMP decarboxylase
Latilactobacillus
MTNPVIIALDFPNWQKTDQFLQQFPKDEALFVKIGMELFYQEGPQLIKTLKARDYRIFLDLKLYDIPNTVQSAMTVIGQLGVDYTTIHAAGGQTMLQAGAAGLKAGAKQANVKPAKLLAITQLTSTNEAQMQQEQLVSVSLPESVAHYAQLAQQSDCDGVICSAQEITTIKSKTATDFLCVTPGIRPATSQNNDQKRAVTPLEAAQMHSNGIVVGRPITQASDPYQAYQAIKSEWESFK
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Q38X21
P55305
CATA_EMENI
Spore-specific catalase
Aspergillus subgen. Nidulantes
MATSITAGLQKAQQAVQDTATKNKKIVDISHDTVNVHTDQEQRTDFGVAITDPDHWLRVTNETHSGPSLLEDHIARERIHRFDHERIPERVVHARGTGAYGNFTLKESIEDLTYAGVLTDTSRNTPVFVRFSTVQGSRGSADTVRDVRGFAVKFYTDEGNWDIVGNNIPVFFIQDAIKFPDFVHAVKPEPHNEVPQAQTAHNNFWDFVYLHPEATHMFMWAMSDRAIPRSYRMMQGFGVNTFSLVNKEGKRHFVKFHWIPHLGVHSLVWDEALKLAGQDPDFHRKDLMEAIDNKAYPKWDFAIQAIPEEDQDKFEFDIFDATKVWPEEQVPLRVVGELELNRNIDEFFPETEQVAFCTSHIVPGIDFSDDPLLQGRNFSYQDTQISRLGVNWEEIPINRPVCPFLNHNRDGAKRHRITKGTVNYWPNRFEANPPASDKGFKSHPAPITGRKRRDLTPKFKEYHNQAQLFYNSLSEVEKVHVKKAFSFELDHCDDPIVYERLAGQRLAEIDLPLAQAVAEMVGAPIPTKALRDNHGKTSVRLSQFDFTPKAPGIISRRIAIIIGDGYDKIAFNGMKAAILAAQALPFVIGTKRSAIYAQGEDKNSSKGVIPDHMYDGMRSTMFDATFIPGGSHIETLQKNGQIRYWIAETFGHLKALGAMGEAAQLVKEVLGNVMGVQIAGADSAEPVEWYGVVTARGPESAESLSEGFKVLKDAGDFTSKFFYQISQHRNWQRELDGLASTVAF
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
P55305
A0T0K5
RR7_PHATC
30S ribosomal protein S7, chloroplastic
Phaeodactylum
MSRRNISKKRFPETDAIYNSYLVSLLISRILKSGKKTIAKKIVYQAFDIIKKKTNEDPLTVFEKAIRNASPIVEVKARRVGGSTYQVPVEVTGFRATNLSLRWIIRYGDQRVGRSMAIKLANEIIDTANDIGNTIKKKEETHKMAEANKAFAHFRY
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
A0T0K5
Q21A81
AROC_RHOPB
5-enolpyruvylshikimate-3-phosphate phospholyase
Rhodopseudomonas
MSFNTFGHMFRVTTFGESHGVAIGCVVDGCPPLIALTEADIQRDLDRRRPGQSRFTTQRQEADQVKILSGVMVHPQSGLQVTTGAPIALLIENTDQRSKDYSEIKDKFRPGHADFTYEAKYGIRDYRGGGRSSARETATRVAAGAIARKVVPGITVRAALVQMGPHQIDRDNWDWEEVGNNPFFCPDKDKAKFFEDYLDGIRKNGSSIGAVIEVVADGVPAGWGAPIYAKLDTDIAAALMSINAVKGVEIGDGFATAALTGEQNADEMRAGNDGPSFLSNHAGGILGGISTGQPVVARFAVKPTSSILAPRKTVDRDGHDTDILTKGRHDPCVGIRAVSVAEAMVACVLADHLIRHRGQIGG
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Q21A81
P56738
CFPA_TREPH
Cytoplasmic filament protein A
Treponema
AILELPQSPNVFHPEKPSAVG
Component of the cytoplasmic filaments that run the length of the organism just underneath the cytoplasmic membrane.
P56738
Q31JM9
ENGB_HYDCU
Probable GTP-binding protein EngB
Hydrogenovibrio
MQHPLYQQATYLKSAPDLSHCPEDFGYEVAFAGRSNAGKSSALNVITSQRGLAKTSKTPGRTQLINFFECDEQRKLVDLPGYGYAKVNVNTKRAWERSLSQYIEVRSSLKGLIMMVDSRMPPTEIDLMMLDWTLTLNLPVHILLTKSDKLKKGPAQNSLLKMRQLLNEKYPHATVQLFSSLKRQGLDEVWAKLDEWMEYERPVKSQPETKES
Necessary for normal cell division and for the maintenance of normal septation.
Q31JM9
Q60CK8
GATA_METCA
Glutamyl-tRNA(Gln) amidotransferase subunit A
Methylococcus
MHRKTLAELAAGLERREFSSVELTQAHLARIERLDPALNSFITTTPEIALAQARAADERLAKGEAGPLTGIPIAQKDIFCTKGVRTSCGSRMLDSFVSPYDACVVERFNAAGAVMLGKLNMDEFAMGSSNETSYYGPVKNPWNTATVPGGSSGGSAAAVAARLVPGATGTDTGGSIRQPAAFCGITGLKPTYGRVSRWGMIAFASSLDQAGPMARTAEDCAIMLQIMAGFDERDSTCVDRPVPDYRAALGNDLDGLRIGLPKEFFGEGLDPAIAGLIHAAVDEYRRLGAIVREISLPNMHLSVPAYYVVAPAECSSNLARFDGVRFGHRCENPTDLADLYTRSRGEGFGAEVKRRILIGTYALSAGYYDAYYLKAQKIRRLISEDFRRAFEEVDVIMGPTAPSVAFEFGAKSADPIAMYLSDIYTIAVNLAGLPGMSIPVGFSNGLPVGMQIIGGYFSEDRLLNVAHRYQQATDWHTRTPAGIAD
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Q60CK8
P9WHQ8
HGPRT_MYCTO
Hypoxanthine-guanine phosphoribosyltransferase
Mycobacterium tuberculosis complex
MHVTQSSSAITPGQTAELYPGDIKSVLLTAEQIQARIAELGEQIGNDYRELSATTGQDLLMITVLKGAVLFVTDLARAIPVPTQFEFMAVSSYGSSTSSSGVVRILKDLDRDIHGRDVLIVEDVVDSGLTLSWLSRNLTSRNPRSLRVCTLLRKPDAVHANVEIAYVGFDIPNDFVVGYGLDYDERYRDLSYIGTLDPRVYQ
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
P9WHQ8
Q98959
3SA3A_NAJAT
Cardiotoxin-3a
Naja
MKTLLLTLVVVTIVCLDLGYTLKCNKLVPLFYKTCPAGKNLCYKMFMVATPKVPVKRGCIDVCPKNSLLVKYVCCNTDRCN
Shows cytolytic activity on many different cells by forming pore in lipid membranes. In vivo, increases heart rate or kills the animal by cardiac arrest. In addition, it binds to heparin with high affinity, interacts with Kv channel-interacting protein 1 (KCNIP1) in a calcium-independent manner, and binds to integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
Q98959
A9VI09
SYA_BACMK
Alanyl-tRNA synthetase
Bacillus cereus group
MKQLTGAQIRQMFLDFFQEKGHAVEPSASLVPHEDPSLLWINSGVATLKKYFDGRVIPQNPRITNAQKSIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKEEAITWAWEFLTSDKWIGFDKELLSVTIHPEDEEAFTIWNEKMGVPKERIIRLEENFWDIGEGPSGPNTEIFYDRGESYGNDFSDPELYPGGENERYLEVWNLVFSQFNHNPDGSYTPLPKKNIDTGMGLERMTSIVQDVPTNFDTDLFMPMIGATESISGEKYRNGDLEKDMAFKVIADHIRTVTFAVGDGALPSNEGRGYVLRRLLRRAVRYSKKLNINRPFMFELVPVVGEVMKDFYPEVLEKKDFIAKVVKNEEERFHETLHDGESILAEVIAKAKEEKTTVISGVDAFRLYDTYGFPIELTEEYAEEAGMTVDQAGFENEMEKQRERARAARQDVDSMQVQGGVLGEVKVASEFVGYGTVATESNVVALVKNGEYTDSLQAGEEGQLMLDVTPFYAESGGQIADRGYLLADGVKVVVKDVQKAPNGQNLHKVVVEEGTLTKDAAVKAVIDTKNRSSVVKNHTATHLLHQALKDILGTHVNQAGSLVTSERLRFDFSHFGQVQADELEKIERIVNEKIWESIDVAISQKAIEEAKEMGAMALFGEKYGDVVRVVQVGDYSLELCGGCHVDNTASIGIFKIVAESGIGAGTRRIEAVTGKSAYELMNDQVGLLKEAAGKMKTNPKDILTRVDGLFTEVKQLQKENESLAAKLSNIEAGNLTDSVMTVDGVNVLAAKVNVADMNNLRTMMDDLKNKLESAVVVLASVNDDKVNILAGVTKDLISQGYHAGKLVKEVASRCGGGGGGRPDMAQAGGKNPAQVEEALAFVQEYVKSVSK
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
A9VI09
Q9ZFA3
SYE1_CERS4
Glutamyl-tRNA synthetase 1
Cereibacter
MPAASDKPVVTRFAPSPTGYLHIGGGRTALFNWLYARGRKGTFLLRIEDTDRERSTPEATDAILRGLTWLGLDWDGEVVSQFARKDRHAEVAREMLERGAAYKCFSTQEEIEAFRESARAEGRSTLFRSPWRDADPTSHPDAPFVIRMKAPRSGETVIEDEVQGTVRFQNETLDDMVVLRSDGTPTYMLAVVVDDHDMGVTHVIRGDDHLNNAARQTMVYEAMGWEVPVWAHIPLIHGPDGKKLSKRHGALGVEEYQAMGYPAAGMRNYLARLGWSHGDDEFFTSEQAMDWFDLGGIGRSPARLDFKKLESVCGQHIAVMEDAELMREIAAYLAAARKPALTDLQAARLEKGLYALKDRAKTFPELLEKARFALESRPIVADDAAAKALDPVSRGILRELTPMLQAASWSKQDLEAILTAFASEKGMGFGKLAAPLRTALAGRTVTPSVYDMMLVIGRDETIARLEDAAAA
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Q9ZFA3
Q88XW2
RS13_LACPL
30S ribosomal protein S13
Lactiplantibacillus
MARIEGIDLPRDKRIVIGLTYIYGIGNTSAQKILAEAGVSEDVRVRDLTPDQEDKIRAVVDGYKTEGDLRREVSLNIKLLQEIGSYRGMRHRRGLPVRGQHTKNNARTRKGKKVSIAGRKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
Q88XW2
B4EUT8
NQRE_PROMH
NQR-1 subunit E
Proteus
MEHYISLFVRAVFIENMALAFFLGMCTFLAVSKNVKTAFGLGIAVTVVLGLSVPLNNLVYNYVLRANALMEGVDLSFLNFITFIGVIAALVQILEMILDRYFPSLYNALGIFLPLITVNCAIFGGVSFMAQRDYNFSESIVYGFGSGIGWMLAIVLLASIREKMKYADVPSGMKGLGVTFVTTGLMALGFMSFSGVQL
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
B4EUT8
Q214F0
CTAA_RHOPB
Cytochrome aa3-controlling protein
Rhodopseudomonas
MPAVPADRPMHAVRIWLAIIAGLIAVMVLVGGATRLTESGLSIVEWKPITGTLPPLSVEQWTQAFDAYKTIPQYRELNAGMTLAQFKTIFWWEWSHRLLGRVIGAAFLLPFLWFLWRGDLGGGLKRRLWIIFGLGALQGAVGWWMVASGLSQRVEVSQVRLATHLVLALLIFAGIVWTLRQLTPRPAIVAPLRLRLTAAVLLGLTFVQLYLGALVAGLRAGRIYNTWPQIDGALIPSAARLWFEQPWWKNLFDNHLTVQFDHRMLAYALWALAVLHAIDAWRARAAAGGALALAVAITLQAALGIVTLLYAVPIGLGLAHQAMAILVLTLAVLQLARFSPGVVQTAQHAAAPSLGQPAQGRG
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
Q214F0
Q91YP2
NEUL_MOUSE
Neurotensin endopeptidase
Mus
MITLCLSALRGLHRAGGSRIRLRMTLGREAASPLQAMSSYTAAGRNVLRWDLSPEQIRTRTEELIAQTKQVYDTVGTINLEDVTYENCLQVLADIEVKYIVERTMLDFPQHVSSDREVRAASTEADKRLSRFDIEMSMREDVFQRIVHLQETCDLEKIKPEARRYLEKSIKMGKRNGLHLPEHVKNEIKSMKKRMSELCIDFNKNLNEDDTSLVFSKAELGALPDDFIDSLEKTDEDKYKVTLKYPHYFPVMKKCCVPETRRKMEMAFHTRCKEENTIILQQLLPLRAQVAKLLGYNTHADFVLELNTAKSTSHVATFLDDLSQKLKPLGEAEREFILSLKKKECEERGFAYDGKINAWDLHYYMTQTEELKYSVDQESLKEYFPIEVVTEGLLSIYQELLGLSFEQVADAHVWNKSVSLYTVKDKATGEVLGQFYLDLYPREGKYNHAACFGLQPGCLLPDGSRMMSVAALVVNFSQPIAGRPSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDIDSLRKLSKHYRDGHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNASLDAASEYAKYCTEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFHSCFRKEGIMNPEVGMKYRNLILKPGGSLDGMDMLQNFLQREPNQKAFLMSRGLNAS
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1.
Q91YP2
Q8RSQ3
PHNX_PSEPU
Phosphonoacetaldehyde phosphonohydrolase
Pseudomonas
MNYKNPTHLQAAILDWAGTVVDFGSFAPTQIFVEAFAEFDVEVSIEEARGPMGMGKWDHIRTLCDQPQIAERYRKVFGRTPTDDDVTAIYQRFMPLQIEKIAVHSALIPGALETLTGLRQNGLKIGSCSGYPKVVMDKVVELAAKNGYVADHVVATDETPNGRPWPAQALANVIALGIDDVAACVKVDDTVPGILEGRRAGMWTVALVCSGNALGLTYEGYRALDPNTLEAERKRIHAMFEGSRPHYLIDTINELPGVITDINQRLARGEMPQAV
Involved in phosphonate degradation.
Q8RSQ3
Q38S11
COX2_HYBUN
Cytochrome c oxidase polypeptide II
Hybomys
MAYPFQLGLQDATSPIMEELTNFHDHTLMIVFLISTLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAVILILIALPSLRILYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLCFDSYMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVSSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFEDWSASMI
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Q38S11
Q6D7E7
NADA_PECAS
Quinolinate synthase
Pectobacterium
MNILFDSNETIYPFPPKPRPLSVDAKQHYRSRIKTLLRERNAVMVAHYYTDPEIQALAEETGGCVADSLEMARFGSTHSASTLLVAGVRFMGETAKILNPEKTILMPTLEAECSLDLGCPIDAFSRFCDAHPDRTVVVYANTSAAVKARADWVVTSSIAVELIEHLDSLGEKIIWAPDRHLGSYVQKQTGADVLCWQGACIVHDEFKTQALQRMKILYPDAAILVHPESPQSVVEMADAVGSTSQLIQAAKTLPQRELIVATDRGIFYKMQQACPEKTLLEAPTAGEGATCRSCAHCPWMAMNGLEAIANGLEQGGHAHEIHVDAALREGALIPLNRMLDFAASLKLRVKGNA
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Q6D7E7
Q8DHY4
MURG_THEVB
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Thermosynechococcus
MLGQRKLLIAASGTGGHLFPALAVAQELPEYEIHWLGVRDRLENQLIPPHYPLHTVNFSGLQGKTPWAKLRPLWQFWGVFWQTRQLLKQGDFQGVFTTGGYIAAPAILAARSLGRVAILHESNALPGKVTRWLAPWCTLVALGTPASLAYLQSKRLNLRVTGTPVRPDILHPGNLELPIPKAVPLIVVMGGSQGAVAINRLVRATVHRWLEAGAWVVHLTGNHDLDAPTIQHPHYLVFPFFEPMGPLLHRADIAISRAGASTLAELTLTATPALLIPYPYAAEDHQTVNAEVLVRAGAAEMIPQSALTGDRLGQIILEWLGQPQKLQAMAENARQLAMPNSSQQVADLIRRLIPAP
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Q8DHY4
O17389
TYB_CAEEL
Tetrathymosin beta
Caenorhabditis
MAAVTELPKMNQELAGAVREGLELKKVETTEKNVLPTKEDVAEEKQHVERIHEIEHFDSTKLHSTPVKEKIVLPSADDIKQEKQHLELTDKINNFPSENLKKTETIEKNVLPSPTDVAREKTLQMAASFDKSALHHVETIVSTDVRVTEAQ
Plays an important role in the organization of the cytoskeleton by regulating actin polymerization in two ways. Firstly, by binding to and sequestering actin monomers (G actin) inhibits actin polymerization. Secondly, by binding directly filamentous actin (F actin) promotes actin polymerization. Regulates the formation of cortical actin in oocytes conferring them enough rigidity to sustain the contractions during ovulation.
O17389
Q9ZEY8
LEU1_BUCAI
Alpha-isopropylmalate synthase
Buchnera
MKSKVVIFDTTLRDGEQALQASLSVKEKLQIALSLEKCGIDILEIGFPVSSPGDFKSVQTISKNIKNSRICSLARCIEKDIDAAGEAMSSSDSFRIHIFLATSTLHMESKLKKNFNEIIDMAVFSVKKALRYTDDIEFSCEDATRTTMDNLCRIVETLIKSGVKTINIPDTVGYTVPNELSCIIKNLFERVPNIHKSIISVHCHDDLGMAVGNSISAIQAGARQIEGTINGIGERAGNTALEEIIMAIKVREDILSVSTNINYKEIYRTSKIVSQICNMPIPSNKAIVGSNAFAHSSGIHQDGVLKNRKNYEIMEPSSIGLKEVKLNLTSRSGRAAVKHYMDEMGYNNSDYNIDELYTAFLKLADKKGQVFDYDLEALAFINKQQDEWEYFSLKFFSVQSISNSLSTASVKLLCGKKTYTESSTTSNGPVDAIYQALNRIACFPIILQKFQLVAKGKGKDALGQVDILVEHKKRKFHGVGLATDIIEASAQAMINVLNNIWKAKQVNKKLKILKDFKKK
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Q9ZEY8
B1WWK9
CYB6_CROS5
Cytochrome b6
Crocosphaera subtropica
MFSKQVTDSKVYQWFNDRLEIQAISDDITSKYVPPHVNIFYCLGGITLVCFLVQFATGFAMTFYYKPTVTEAFSSVQYIMNEVNFGWLIRSIHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWMTGVILAVITVSFGVTGYSLPWDQVGYWAVKIVSGVPAAIPVVGDQMVELLRGGQSVGQATLTRFYSLHTFVFPWLIAVFMLAHFLMIRKQGISGPL
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
B1WWK9
B5FCQ1
RUVA_ALIFM
Holliday junction ATP-dependent DNA helicase RuvA
Aliivibrio
MIGRLRGNLLEKQPPELLIEVSGIGYEVQMPMSCFYELPEVGSEAIIYTHYVVREDAQLLYGFNTKNERALFREVIKANGVGPKLGLAILSGMTAAQFVQSVEREDISTLVKLPGVGKKTAERLVVEMKDRLKGWGAGDLFTPATDAAPMDDGSEFITSPQSAVDEAVSALIALGYKPQQASKTVSQVAKPDMTSEVLIRESLKSMI
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
B5FCQ1
Q9X5D0
AROC_CORGL
5-enolpyruvylshikimate-3-phosphate phospholyase
Corynebacterium
MLGMLRWTTAGESHGQALIATVEHMPAGVPVTKDEVSYQLARRRLGYGRGARMKFEQDALTFLTGIRHGLTLGSPISIMIGNTEWDKWTTIMSSDALDMEDPDNVAAMSSGRGAKLTRPRPGHADYAGMLKYGFDDARNVLERSSARETAARVAAATVARSFLRETLGVEVLSHVISIGASEPYTGAEPTFADIQAIDDSPVRAFGKDAEESMIAEIEAAKKAGDTLGGIVEVIVEGLPIGLGSHISGEDRLDAQIAAALMGIQAIKGVEIGDGFEEARRRGSEAHDEVFLDDNGVYRNTNRAGGLEGGMTNGETLRVRAGMKPISTVPRALKTIDMENGKAATGIHQRSDVCAVPAAGVVAEAMVTLVLARAVLQKFGGDSLSETKSNIDTYLKNIEERMKFEGLEDGA
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Q9X5D0
O43598
DNPH1_HUMAN
c-Myc-responsive protein RCL
Homo
MAAAMVPGRSESWERGEPGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQPSLGVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADPPGQVAASPDPTT
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
O43598
Q3J049
FOLD_CERS4
Methenyltetrahydrofolate cyclohydrolase
Cereibacter
MTAKRIDGKAFAAGVRARVAEEVARLKEGHGIVPGLAVVLVGEDPASQVYVGAKGKQTVEVGMASFEHRLPAGTSEAELLALIDRLNHDPAVHGILVQLPLPAHLNADLVINALDPAKDVDGFHISNVGRLGTGQKSMVPCTPLGCLMMLRDHLGALSGLNAVVVGRSNIVGKPMAQLLLGESCTVTIAHSRTRDLAAVCRGADILVAAVGRPEMITGDFVKPGATVIDVGINRIERDGKTKLVGDVDYASAAEVAGAITPVPGGVGPMTIACLLANTLTACCRANGLPEPQGLTA
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q3J049
Q14H27
RPIA_FRAT1
Phosphoriboisomerase A
Francisella
MFFNKKNNQDELKKLAATEAAKSITTEITLGVGTGSTVGFLIEELVNYRDKIKTVVSSSEDSTRKLKALGFDVVDLNYAGEIDLYIDGADECNNHKELIKGGGAALTREKICVAAAKKFICIIDESKKVNTLGNFPLPIEVIPMARSYIARQIVKLGGQPVYREQTITDNGNVILDVYNLKIDNPLKLETELNQITGVVTNGIFALKPADTVIMATKDSNIVVL
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Q14H27
C5DD31
RRG9_LACTC
Required for respiratory growth protein 9, mitochondrial
Lachancea
MKPVLQGALAWIYAGYKTASRGHLLPYTRHQKFHSSSLISEQAKRAKDLIKLVNSSSLSNSESQSLDWRSDLKVPEWKRQKLALKDKFKGQQWNPKKKLSREQMENVRLLKRHFPETSATELSERFQVSPEVIRRILKSKWQPNEEEQLQLQTRWKRRSERVNEILGSPEHQKLPPKKLVLGSGRTDTDLQVKSVRRTAVKAGRNSSSPKGKQKLNLLSKLIS
Required for respiratory activity and maintenance and expression of the mitochondrial genome.
C5DD31
Q606D6
ILVD_METCA
Dihydroxy-acid dehydratase
Methylococcus
MTDKHPRPHSSQVVDGMERAPSRAMLHAVGFADADFAKPQIGIASTWAMVTPCNMHINKLAEDAARGVDGGGGKAVIFNTITISDGISMGTEGMKYSLVSREVIADSIETVVACQGYDGVVAIGGCDKNMPGCLIALARLNRPAVFVYGGTILPGCHDGKKLDVVSVFEAVGARANHRIDDAELHAIESNAIPGPGSCGGMYTANTMASAIEALGMSLPGSSAQVAISRAKELDCERAGAQVLKLLDLGLKPRDIMTKKAFENAITVVIALGGSTNAVLHLLAMANACGVDLKLDDFTRIGRKVPMLADLKPSGRYSMAELVEIGGIQPLMKTLLDAGLLHGDCMTVTGKTLEENLADAPDYPAGQDMIRSLDNPIKKDSHLVILKGNLAPEGAVAKITGKEGLSFTGTARVFDCEEAALTAILDGTIVKGDVIVIRYEGPKGGPGMREMLSPTSAVMGKGLGKEVALITDGRFSGGTHGFVVGHITPEAYTGGPLAIVRDGDTITIDAETRELSLHVTDDEIGRRLAQWTQPAPRYTKGVLAKYARLVSPASEGAVTDDGL
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Q606D6
Q9V780
LAP1_DROME
Protein lap1
Sophophora
MPLLSKCFPCFKFKREEVIDKLDYSNTPLTDFPEVWQHERTLEELYLSTTRLQALPPQLFYCQGLRVLHVNSNNLESIPQAIGSLRQLQHLDLNRNLIVNVPEEIKSCKHLTHLDLSCNSLQRLPDAITSLISLQELLLNETYLEFLPANFGRLVNLRILELRLNNLMTLPKSMVRLINLQRLDIGGNEFTELPEVVGELKSLRELWIDFNQIRRVSANIGKLRDLQHFEANGNLLDTLPSELSNWRNVEVLSICSNSLEAFPFSVGMLKSLVTFKCESNGLTELPDSISYLEQLEELVLSHNKLIRLPSTIGMLRSLRFLFADDNQLRQLPDELCSCQQLSVLSVANNQLSALPQNIGNLSKMKVLNVVNNYINALPVSMLNLVNLTSMWLSDNQSQPLVPLQYLDASTKTQLTCFMLPQVTFKMNSIQAQQQAQEQYEFVYANQQQPHASPSRRICFAEEATILSNAKAQPAPNYPSFVAAPPTPTPDQMAGSVRLMRSPTPYPKELRQMSKYVRQAQAATSSANASEVREARVVTNGQIHCDSNNANQDVVDQATTSAIYGIAPETTHIYGVYQQPQQMAHPVPTQEYYGLPLVNYEAHYQQLYVEANTPLPTTHLNGDQDYELQPLQQQPMQQQALPTPRLEPPPYHIARVYTKKTPEDLNLYESMRQRKQQQQLQEQTIYQDALNSNSNFKTTAIGAQDVEESVDQLDYQNNISNNLEPNPEEEDQELDDTMSQHSLNSTATNNTSKASHKKSTWIFGVHKNPTVKQVTLKWENSIGFDIAELLNQVGIFVSSITPNTNAARLLNLNDKLLEIDGYDLTNANLSDAKRVLLNCGTVMNIMLSRK
May have a role in assembling adherens junctions.
Q9V780
A3QEG3
TTCA_SHELP
tRNA 2-thiocytidine biosynthesis protein TtcA
Shewanella
MSEETLSKKQITRLNKLQKRLRREVGSAIADYNMIEEGDTVMCCLSGGKDSYAMLDILVNLLQRAPVNFNLVAVNLDQKQPGFPEDILPAYLDSLKVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQKIGATKIALGHHRDDIIETMFLNMFYAGKLKAMPPKLLSDDGANVVIRPLAYSREKDIAEYAELKAFPIIPCNLCGSQENLKRAAVKEMLKSWDKQFPGRIETIFTAMQNTSPSQGVDRDQFDFVSLKQDPDAPMKGDVAESDLPAFDFLDLANSGHIDLDAAKRSSDLLKIDVVSTYTP
Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.
A3QEG3
Q97L49
SSRP_CLOAB
Small protein B
Clostridium
MAKKNTENNTLADNRKAWHDYFIEETYECGVELVGTEVKSIKNGKANLKDSYAEIRNGEVFACNMHVSPYKEGNIFNVDPLRKRRLLLHKSEIDKLLGFTSQKGYTLVPIALYLKNRRVKVKLAVAVGKKNYDKRDALKEKDARREIDRAMKNNR
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
Q97L49
A3MKT0
LPXA_BURM7
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
pseudomallei group
MSRIHPTAIIEPGAQLHETVEVGPYAIVGSHVTIGARTTIGSHSVIEGHTTIGEDNRIGHYASVGGRPQDMKYKDEPTRLVIGDRNTIREFTTIHTGTVQDTGVTTLGDDNWIMAYVHIGHDCRVGSHVILSSNAQMAGHVEIGDWAIVGGMSGVHQFVRIGAHSMLGGASALVQDIPPFVIAAGNKAEPHGINVEGLRRRGFSPDAISALRSAYRILYKNSLSLEEAKVQLSELAQAGGDGDAAVKSLVDFVESSQRGIIR
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
A3MKT0
Q2NAH8
SYP_ERYLH
Prolyl-tRNA synthetase
Erythrobacter
MSNIRHALTVKREDDFAAWYQAVIAEADLAEESGVRGCMVIKPWGYGIWERIQRLLDDRIKATGHENVYFPIFIPLSNFEREAEHVEGFAKEMAVVTHHRLIGDGEGGLIPDPEAKLEEPLVVRPTSETIFGDAMARWIQSWRDLPLLTNQWANVVRWEMRTRMFLRTSEFLWQEGHTAHATAEEAKEHTLTMLEVYRAHAEEDLALPVIAGEKPENERFPGAVETWSIEAMMQDGKALQAGTSHYLGTNFSEAANIKFQDREGGEKYCHTTSWGVSTRMIGGVIMTHGDDDGLKVPPRIAPYQVVILPMLRDKPEDDALLAYCEDLRGKLITESAMGEPVRVLLDKKPGKAAAKRWNWVRKGAPIVIEVGGRDMENGVVSLLRRDELWNEETGKPAFQAPTPAQLTDEIASMLDSIQAGMFGTAQTWRNANVMSGCTSFEQLRDHYSDGKKHVGWVEVQWSKPTGQELEKVVEKLKDLKLTIRNVPMDTPAPTGSCIFTGKPAVEWIYVAKAY
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Q2NAH8
O69652
CDS1_MYCTU
L-cysteine desulfhydrase Cds1
Mycobacterium tuberculosis complex
MSGGACIAVRSLSRSWTDNAIRLIEADARRSADTHLLRYPLPAAWCTDVDVELYLKDETTHITGSLKHRLARSLFLYALCNGWINENTTVVEASSGSTAVSEAYFAALLGLPFIAVMPAATSASKIALIESQGGRCHFVQNSSQVYAEAERVAKETGGHYLDQFTNAERATDWRGNNNIAESIYVQMREEKHPTPEWIVVGAGTGGTSATIGRYIRYRRHATRLCVVDPENSAFFPAYSEGRYDIVMPTSSRIEGIGRPRVEPSFLPGVVDRMVAVPDAASIAAARHVSAVLGRRVGPSTGTNLWGAFGLLAEMVKQGRSGSVVTLLADSGDRYADTYFSDEWVSAQGLDPAGPAAALVEFERSCRWT
A cysteine desulfhydrase that generates hydrogen sulfide, H(2)S. The H(2)S produced by this enzyme stimulates respiration in M.tuberculosis, mediated primarily via cytochrome bd with a lesser contribution from cytochrome bc1/aa3. H(2)S modulates the balance between respiration and glycolysis, and also contributes to redox homeostasis. Probably eliminates toxic levels of Cys (which can induce oxidative stress).
O69652
C5K3T8
DRE2_BLAGS
Anamorsin homolog
Blastomyces
MASTGRVLLLSPPSLSSHPEKLNAILGSHTRDRTDLQMLDRLVHGLVSLPASTYDIVLLLTGADNTLAEPYSLVTRDIIQQVVHSLKPAGKLRSQDNKAWGLRSSGNNSDDDNDNDELTFRNEAILAGLVFDDNGELLKPDVAAQQAVPLKLGRRKKEKERRHPSGNDVTNGKVNAPSSNGVNASTSTATATATTTTTTTPKTNPAPSGVGFIDFSDDYGVPMEEDPQGSDDELIDEDELLGEDDMGRPIVQPPECRPKPGKRRRACKDCSCGLSQKLEAEDKAKRATADKALETIMAPTMKLGSSELAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGLPAFKPGEEVRLLNNDVQL
Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.
C5K3T8
P50537
MAE1_SCHPO
Malate permease
Schizosaccharomyces
MGELKEILKQRYHELLDWNVKAPHVPLSQRLKHFTWSWFACTMATGGVGLIIGSFPFRFYGLNTIGKIVYILQIFLFSLFGSCMLFRFIKYPSTIKDSWNHHLEKLFIATCLLSISTFIDMLAIYAYPDTGEWMVWVIRILYYIYVAVSFIYCVMAFFTIFNNHVYTIETASPAWILPIFPPMICGVIAGAVNSTQPAHQLKNMVIFGILFQGLGFWVYLLLFAVNVLRFFTVGLAKPQDRPGMFMFVGPPAFSGLALINIARGAMGSRPYIFVGANSSEYLGFVSTFMAIFIWGLAAWCYCLAMVSFLAGFFTRAPLKFACGWFAFIFPNVGFVNCTIEIGKMIDSKAFQMFGHIIGVILCIQWILLMYLMVRAFLVNDLCYPGKDEDAHPPPKPNTGVLNPTFPPEKAPASLEKVDTHVTSTGGESDPPSSEHESV
Permease for malate and other C4 dicarboxylic acids.
P50537
B2KC93
RIMP_ELUMP
Ribosome maturation factor RimP
Elusimicrobium
MRDIKAIESVVADGLANQGYEVVDLIVQNQGSKKLFQFFVDKEGGINLDDVEKASRLIDSIIEMENLIEGAYILEASSPGIKRVLKKPEHFKKFIGQRAKITLKQMIENRANFTGLIAGANETEMTLDDGTTQFKFKYEDIKKANLDPVLEF
Required for maturation of 30S ribosomal subunits.
B2KC93
Q98NP5
RS4_RHILO
30S ribosomal protein S4
Mesorhizobium
MSKRESAKYKIDRRLGENIWGRPKSPVNKREYGPGQHGQRRKGKLSDFGLQLRAKQKLKGHYGDVSEKQFRKVYEEADRRKGDTSENLIGLLESRLDAVVYRAKFVPTIFAARQFVNHGHVNVNGKRVNIGSYRCKPGDVIEVREKSKQLVIVLESVGLAERDVPDYIEADHNKMVATFSRIPGLADVPFAVQMEPNLVVEFYSR
With S5 and S12 plays an important role in translational accuracy.
Q98NP5
Q5HAK5
RUVA_EHRRW
Holliday junction ATP-dependent DNA helicase RuvA
Ehrlichia
MIGSITGNVEEIRDSYIILNVGNIGYIIYVSHKVLQTCKVGDNIKLYIETYVNRDNITQLYGFLNRQEQDYLKMLVTINGINYKTALSILSKLSPEQIFSAVVNNDKIAFKGNGIGEKLAGRIITELQYKINKMPIEETFSIIENDDSLAALISLGYEKLKAFNVIQEIKSKTPDASTQEVIRKALQKLSQ
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
Q5HAK5
P85302
AMPC_PSEFL
Cephalosporinase
Pseudomonas
ATDIRQVVDSTVEPLMQQQDIAGLSVAVIQNGKAQYFNYGVANKDSKQPITENTLFEIGSVSKTFTATLAGYALANGKLKLSDPASQYLPALRGDKFDHISLLNLGTYTAGGLPLQFPEESDNTGKMISYYQHWKPAFAPGTQRLYSNPSIGLFGHLAAQSLGQPFEKLMEQTVLPKLGLKHTFISVPETQMSLYAQGYDKAGKPVRVSPGALDAEAYGIKTSTSDLIHYVEVNMHPAKLEKPLQQAIAATHTGYYTVDGMTQGLGWEMYPYPIKVDALVEGNSTQMAMEPHKVNWLTPPQAAPLDTLVNKTGSTGGFGAYVAYVPSKGLGVVILANKNYPNAERVKAAHAILSAMDQ
This protein is a serine beta-lactamase with a substrate specificity for cephalosporins.
P85302
A5CW25
RPOB_VESOH
Transcriptase subunit beta
Candidatus Vesicomyosocius
MAYSFTEKKRIRNNFGSRESILTEPDLLAIQIDSFNSFIQADNKIKQDIGLHNVLQSVFPITAVNGYAQIEYVDYQLKEPKFNVEECKLRGVTFASTLRVKLNLVLFDKNGSTLKKKRKVKQIIEEDVYLGQLPLMTETGTFVINGTERVVVSQLHRSPGVIFEHDKGKTHSSGKILFSSRIIPYRGSWLDFEYDHHEHLYVRIDRRRKLPVTTLLRAMGLSSEDILETFFEKTPVKLKAKSCDLSMLPIHLQRTIAEFDIVVNQHVVVEKGRRITAKHVKLLGKAGIKSINAPLEYLLDKVICADIINKDTGEILISANTITSEEVLELLNTNKVKKIEILYINSSETGAYISDTLRLDETQTEIEARMSIYHVMRPGEPATEDAVNLLFNNLFFKNDRYDLSKVGRMKLNRRLGISRETGEHVLTNDDIIRVIKLLINIKDGNDSVDDIDTLANRRVRAIGEMIENQFRIGLVRVEKAVREGLNLAETDELTPQDLINSKPVSAAVREFFGSSQLSQFMDQVNPLSGVTHKRRISALGPGGLTRERAGFEVRDVHPSHYGRLCPIETPEGPNIGLINTLAVYAKTNSYGFLETPYQIVKNGKVTKEVIYVSAIDEITHTIAQANALVDDRGKLMDDLISCRHKNEFVLVDSSEVTLIDIDSKQISSVAASLIPFLEHDDANRALMGSNMQRQAVPVLKAEKPLVGTGIERVVAKDSRVCVTAKHGGVVEAVDASRIVIRVDSKKTKANELGVDIYNLTKYSRSNQNTCINQKPLVRTGDKITFGDVLADGPSTDMGELALGQNMKIAFMPWNGYNFEDSILISEKVVQEDRYTTIHIEELTAYSRDTKLGPEEITSDIPNVSESALSKLDEVGVVYVGARVKGGDILVGKVTPKSETVLSPEEKLLRAIFGEKANNVKDSSLRIGASKSGVVIDVQVFTRDRVEKDIRALSIDAERLERIKKDIDDEFSIIDGDIFRRIRLKLLGNVLSKAIGDIRIGERLSIKLMKKFDNKDIAKFKVENATVNKEVAVLVKQAKAKKVEFEKFFKKEKAKINEGAELPPGVMKMVKVYVATRKTLQVGDKMAGRHGNKGVISRVSPVEDMPYLADGSTIDIVLNPLGVPSRMNVGQVLEVHLGYAAKGLGYKIAAILDERRPDMVKQIRVFLDKVYNLHGKKEDLTLFSNEEIIELANNLREGVPMATPVFDGIREQDIKSLLRLADLPESGQEQLYDGRTGEPFDRHVTVGYMHMLKLNHLVDDKMHARSTGPYSLVTQQPLSGKAQFGGQRFGEMEVWALEAYGAAHTLREMLTVKSDDVAGRAKMYKSIVDGKNLTESVMPESFNVLVKEIRSLGIDVELEQH
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A5CW25
Q6ED65
EMAL5_RAT
Echinoderm microtubule-associated protein-like 5
Rattus
MAARSAPSCHLRLEWVYGYRGHQCRNNLYYTAAKEIVYFVAGVGVVYSPREHRQKFYRGHSDDIISLALHPERVLVATGQVGKEPYICVWDSYTVQTVSVLKDVHTHGIACLAFDLDGQRLVSVGLDSKNAVCVWDWKRGKMLSMAPGHTDRIFDISWDLYQPNKLVSCGVKHIKFWSLCGNALTPKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWKGINLIRTIQGAHTAGIFSMNACEEGFATGGRDGCIRLWDLTFKPITVIDLRETEQGYKGLSVRSVCWRGDHILVGTQDSEIFEIVVHERNKPFLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALIARCNMDEPIRCAAVNADGVHLALGMKDGSLTVLRVRDMTEVVHIKDRKEAIHELKYSPDGTYLAVGCNDSSVDIYGVAQRYKKVGECVGSLSFITHLDWSSDSKYLQTNDGSGKRLLYKMPGGKEVTSKEEVKGMHWASWTCVAGLEVNGIWPKYSDINDINSVDGNYVGQVLVTADDYGVVKLFRYPCLRKGAKFRKYIGHSAHVTNVRWSHDYQWVISIGGADHSVFQWKFIPERKLKDALHIAPQESLTESNSDESDSDLSDVPELDSEIEQETQLTYHRQVYKEDLPQLKEQCKEKQKSATSKRRERAPGNSIRLHFIHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDDILCLAIHPLKDYVATGQVGRDPSIHVWDTETIKPLSILKGYHQYGICAVDFSADGKRLASVGIDDSHTIVLWDWKKGEKLSVARGSKDKIFVVKMNPYVPDKLITAGIKHMKFWRRAGGGLIGRKGYVGTLGKNDTMMCAVYGWTEEMAFSGTSTGDVCIWRDVFLVKTVKAHDGPVFSMHALEKGFVTGGKDGVVALWDDSFERCLKTYAIKRADLAPGSKGLLLEDNPSIRAISLGHGHILVGTKNGEILEVDKSGPVTLLVQGHMEGEVWGLATHPYLPICATVSDDKTLRIWDLSPSHCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSFHHRKDVISDIQFSPGSGKYLAVASHDSFVDIYNVTSSKRVGVCKGATSYITHIDWDSRGKLLQVNTGAKEQLFFEAPRGKKQTIPSVEVEKISWATWTSVLGLCCEGIWPIIGEVTDVTASCLTSDKMVLATGDDLGFVKLFRYPAKGKFGKFKKYVAHSTHVTNVRWTYDDSMLVTLGGADMSLMVWTSEVERHREKKNCDSEESDTDSEEDGGYDSDVTRENEISYTIRALSTNIRPMFGVKPHLQQKEPSVDERQGVVRGSRPPVSRAPPQPEKLQSNNVGKKKRPIEDLVLELAFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGTQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSVHIWDAVNKQTLSILRCSHSKGVCSVSFSATGKLLLSVGLDPEHTVTIWRWQEGAKIASRGGHNQRIFVAEFRPDSDTQFVSVGIKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAVAFGANNLTFTGTISGDVCVWKDHILCRVVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQVTDCVRSVCRGKGKILVGTRNSEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADSRHLQVSSGCYKRHVYEVPSGKHLVDHAAIDRITWATWTSILGDEVMGIWSRHAEKADVTCACVSHSGISLVTGDDFGMVKLYDFPCPEKFAKHKRFLGHSPHVTNIRFTSGDRHVVSAGGDDCSVFVWKCVHTPH
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.
Q6ED65
A9L9A5
ACCD_LEMMI
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic
Lemna
MEKLWLNSMFSNGKLEHKYRLSRSMDSLGPIRYSSGSEDPVLNAMDNKVSSWNDSGSCNFSNVEHFLDIIDIWSFISDDTFLVRDSNGDSFSIYFDIENQIFEIDNDSTFINELESSFSSYLDSSSMNSGSKKSSRYYYRYMYDTQSSWNNHINSCIDSYLRYEISIDSYISGETHNYSDNYVYNFICNESISGNESRNSAIRTSVNGSDFNIRGRSNDLDINKKYRHLWVQCENCYGLNYKQFFRSRLNICEHCGYHLKMSSSERIELLIDPGTWDPLDENMVSTDPIEFHSEEEPYRDRIDSYQKKTGLTEAVQTGIGELNGIPIAIGVMDFQFMGGSMGSVVGEKITRLIEYATNKSLPVIIVCASGGARMQEGSLSLMQMAKISSALYNYQLNKKLFYVAILTSPTTGGVTASFGMLGDIIIAEPNAYIAFAGKRVIEQTLNKTVPDGSQAAEYLFQKGLFDLIVPRNLLKGVLGELFQLHGFFPLT
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
A9L9A5
Q55C77
FCL_DICDI
GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase
Dictyostelium
MTETTSKRTVLVTGGSGLVGKGIEKYVKETDKSNDVWVFMRSSDCDLKSRESTRSYFEKIKPTHVIHLAARVGGLFSNMKYKVEFFRENIDINDNVLACCKEFNVVKCVSCLSTCIFPDKTTYPIDETMIHNGPPHPSNEGYAYAKRMIDVLNRAYNEEYGCKFTSVIPTNIYGPHDNYHLTDGHVIPGLIHKTYLAMKNNQDLTIMGTGKPLRQFIYSYDLAKYFVWTLNNYEEMSPLILSVGEEDEISIADVARLITEAMEFKGKLIFDTSKADGQYKKTASNLKLKSLVPDLTFTPIQQAIKESCQWFIDNYETARK
Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
Q55C77
Q74IR9
ISPT_LACJO
Isoprenyl transferase
Lactobacillus
MSESKKPLNHLAIIMDGNGRWAKKRHLPRFVGHRHGMDNIRNIALAANKLGIKVLTLYAFSTENWARPTDEVNYLMRLPIDFFDKFMPELMENNVRVNIMGFVDELPEKTYLVTQKAMAETANNTGMVLNFAFNYGSRREITAGVQEIARKVKVGEIDIDDISEKMVSDHLLTHSLAPYEDPDLLIRTSGEERLSNFLLWQMAYTEFSFSDKLWPDFDKTDLEELVKDYQGRNRRFGKV
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
Q74IR9
Q1RQI9
THIO_MALSM
Allergen Mala s 13
Malassezia
VQVISSYDQFKQVTGGDKVVVIDFWATWCGPCKMIGPVFEKISDTPAGDKVGFYKVDVDEQSQIAQEVGIRAMPTFVFFKNGQKIDTVVGADPSKLQAAITQHSA
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Q1RQI9
F1MMS9
ITA3_BOVIN
Integrin alpha-3 light chain
Bos
MGPGPSRAAGVLRPLLGMLALMVAASNRAASAFNLDTRFLVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRDLAVPDGYTNRTGAVYLCPLTAHKNDCERMDIKEKSNPNHIIEDMWLGVTVASQGPAGRVLVCAHRYTQVLWSGSEDQRRMVGKCYVRGNDLELDARDDWQTYHNEMCNSNTDYLETGMCQLGTSGGFTQNTVYFGAPGAYNWKGNSYMIQRKDWDLSEYSYKDPEDQGNLYIGYTMQVGSAILHPTNITIVTGAPRHQHVGAVFLLSQEAGGDLRRRQVLEGTQVGAYFGSAIALADLNNDGWQDLLVGAPYYFERKEEVGGAIYIFMNQAGTSFPDHPSLLLHGPSRSAFGFSVASIGDVNQDGFQDIAVGAPFEGLGKVYIYHGSSRGLLRQPQQVIHGEQLGLPGLATFGYSLSGQMDVDENFYPDLLVGSLSDRIVLLRARPVINILHKTLVAKPSILDPAFCTATSCVQVELCFAYNQSAGNPNYRRNITLAYTLEADRDRRPPRLHFARSQSAVFHGFFSMPEMRCQTLELLLMDNVRDKLRPITISMNYSLPLRLPDRPQLGLGSLDAYPVLNQAQALENHTEVQFQKECGQDNRCDSNLQMRAAFVSELGQRLSRLQYRRDLRKLLLSINVTNTPSRKRAGEDAHEALLTLEVPPTLLLSSVRPPGACQANETIVCELGNPFKRNQRMELLIAFEVIGVTLHTRELQAQLQLSTSSHQDDLRPMTLPLLVDYTLQASLSMVNHRLQSFFGGTVMGESGMKTVEDVGSPLKYEFQVGPMGEGLAALGTLVLGLEWPYEVSNGKWLLYPTEITVHGNGSWHCQPPGDLINPLNLTLSVPGDGPPSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSEIQLSCGSDHTHCVWLECPIPDAPVITNVTIQARVWNSTFIEDYRDFDRVRVASWATLFLRTGVPTINMENKTVRFSVDIDSDLVEELPAEIELWLVLVAVSAGLLLLGLIILLLWKCGFFKRARTRALYEAKRQKAEMKSQPSETERLTEDY
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
F1MMS9
Q869U7
RS18_DICDI
40S ribosomal protein S18
Dictyostelium
MSSSLVFQGEFQHIIRIYNTNVDGRRKIQYALTCVKGVGRRFANLVCKKADIDTSKRAGELSKDEVERLTTIMNHPRQYNIPTWFLNRQKDIKDGKYSHCLANQIDVKFREDLERLKKIRAHRGVRHHFGLRVRGQKTKTTGRRGRTVGVAGRR
Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.
Q869U7
P32048
SYKM_YEAST
Lysyl-tRNA synthetase
Saccharomyces
MNVLLKRRSLTFAPRWLWCKCRSSRSRPYSLAHAVDTSKMEATRRNGQIVKDLGRYYPSMSESALHDLCQEYKEVTIADFNERFLGNPATLHHEDNPNLLLSINGRIKSIRFSGQKIVFIDLYNGSSGLKNDTQLQLIVNYNKIGGSSEDKANFSEYMNFLKKGDYIKALGYPGFSQSRVKMLSLICNKLPIVLSVSQLPLPSRLNDETKIKSNRVVDYQLNGTQTLLVRARIIKLLRKFLDDRNFVEVETPILSSKSNGAMAKPFITSSKDFDHLELRIAPELWLKRLIISGLQKVYEIGKVFRNEGIDSTHNAEFSTLEFYETYMSMDDIVTRTEDLFKFLITNLQKFFQDTRLPVPKTFSELHLALSENNWKFRKVEFLPTLNKELGIDLMNSGLDINKPSELLKALPKDIAKKYFPSADNTGQLSSLQILNKLSDVFLEQRHCQSTLPTVIYHQPAILSPLAKTDPQNKQVTKRFEVFIKGKEYINAYEEENCPQLQLQKFLQQKQINELTGNKTETLSPVIDYQYVETMKYGMPPVGGFGLGIDRLCMLFCDKKRIEEVLPFGCVDDVNRQ
Catalyzes the attachment of lysine to tRNA(Lys) in the mitochondrion.
P32048
B0UWF1
TORD_HISS2
Chaperone protein TorD
Histophilus
MITLNTEEKIFIYSWLKNILSHELTEQQLQQYQQGVFTPLFDFLSEQDLAKQINTVRNSLMQLSNLPLAHLELAADFAQLFLLNGENSALPYASAYLSEKELNQHIAFIDHLLFKYQLKFDHNLREPSDHLAVYLELLITLEKSGQKEKSFNFIQHYLLAWLIPFNKKVQKIKTETSFYQAITEILITLLNKNVKLS
Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
B0UWF1
P0AC14
DHPS_ECOL6
Dihydropteroate pyrophosphorylase
Escherichia
MKLFAQGTSLDLSHPHVMGILNVTPDSFSDGGTHNSLIDAVKHANLMINAGATIIDVGGESTRPGAAEVSVEEELQRVIPVVEAIAQRFEVWISVDTSKPEVIRESAKVGAHIINDIRSLSEPGALEAAAETGLPVCLMHMQGNPKTMQEAPKYDDVFAEVNRYFIEQIARCEQAGIAKEKLLLDPGFGFGKNLSHNYSLLARLAEFHHFNLPLLVGMSRKSMIGQLLNVGPSERLSGSLACAVIAAMQGAHIIRVHDVKETVEAMRVVEATLSAKENKRYE
Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
P0AC14
B2GAU2
ATPD_LIMF3
F-type ATPase subunit delta
Limosilactobacillus
MSRLDQKTVANRYARAIFELAQEDGQLDQTYQELVSVRQVFLDNPSLAPLLAGVDLGIKEKQALVDQVKEGASKYVANLLQMAFDYRRMSDMVAIVDEFERRYDEKHKRVHAEVVTAVQLDETRRNQLRDNLAARLGAQEIVLNEKVDPTILGGVVVKTANQTLDGSIKTKIEQIRRLIVK
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
B2GAU2
B8I4D2
FLIW_RUMCH
Flagellar assembly factor FliW
Ruminiclostridium
MLVKTTHFGEINIKDEDIIEFSEGIVGFEDIHRYGIIRNQNSDSPFSWLQAVEKSELAFAVVDPFVIKKDYDFVLSDEYVKALDINDPSQVNVYAIVVVPDDLTKISMNLKAPVIVNKDNRKAAQVILDTDEYTVRHYIMDELQKQEV
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
B8I4D2
Q7L2Z9
CENPQ_HUMAN
Centromere protein Q
Homo
MSGKANASKKNAQQLKRNPKRKKDNEEVVLSENKVRNTVKKNKNHLKDLSSEGQTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFLKKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex . Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores .
Q7L2Z9
B2RL45
RPOB_PORG3
Transcriptase subunit beta
Porphyromonas
MTPTTNNKRINFASIKNPLFYPDFLEVQLKSFHDFLQLDTPPERRKKEGLYKVFAENFPITDTRNNFVLEFLDYYIDPPKYSIEECLSRGLTYSVPLKAKLKLYCTDPDHEDFATVIQDVFLGPIPYMTSSGTFVINGAERVIVSQLHRSPGVFFGQSLHTNGTKLYSARIIPFKGSWIEFATDINNVMYAYIDRKKKLPVTTLLRAIGFEADKDILDIFNLAEEVKVTKANLKKCIGRKLAARVINTYIDDLSDEDTGEVVSMERITVVVDREVELTEDNIEAILNSNTQTILLHRNDSNTSDYSIIFNTLQKDPCNSEKEALYYVYRQLRNAEPADDASAREVITNLFFSDKRYDLGDVGRYRINKKLNLNIDPDIKVLTNEDIIEIIKYLIELVNSKASVDDIDHLSNRRVRTVGEQLYNQFGIGLARMARTVRDRMNVRDNEVFTPIDLVNAKTISSVVNSFFGTNALSQFMDQTNPLAEITHKRRLSALGPGGLSRERAGFEVRDVHYTHYGRLCPIETPEGPNIGLISSLCVYAKISDLGFITTPYREVKNGKVDFSDNGLKYYTAEEEEEKTVAQGNAPLDENGRFVRERVKARYESDFPLVTPDEVDLMDVSPTQIASIAAALIPFLEHDDANRALMGSNMMRQAVPLLRPESPIVGTGIEGKLVKDSRTQIVAERGGEVVFVDASCIKIRYDRTADEEFVSFDDAIVTYYLPKYRKTNQSTTIDLHPICSKGDRVEAGQILTEGYSTQGGELALGRNVQVAYMPWKGYNYEDAIVLNERMVREDFFTSVHVDEYILEVRETKRGLEELTSDIPNVSEDATRDLDENGIVRIGAHIEPGDILIGKITPKGESDPTPEEKLLRAIFGDKAGDVKDASLKATPSLRGVVIDTKLFSKAAKKKSRTSTKETVSKLDETYAKRQQQLHERLIEKLTELTKGKTCCGVKDYLNVELIKAGSKLTKKDLEALDFNVIQLSDWTNDAHTNELIKAVAVNYLKHSKEIEAELRRRKLDETIGDELPAGIVQMAKVYIAKKRKIQVGDKMAGRHGNKGIVSKIVRQEDMPFLADGTPVDICLNPLGVPSRMNLGQIFEAVLAWAGRKMNVKFATPIFDGASLNDMNEWTDKAGLPRDGKTYLYDGGTGERFDQPATVGVTYFLKLGHMVDDKMHARSIGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAFGASHILQEILTVKSDDVVGRSKAYEAIVKGDPMPTPGIPESLNVLLHELKGLGLSFSLD
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B2RL45
Q9NV29
TM100_HUMAN
Transmembrane protein 100
Homo
MTEEPIKEILGAPKAHMAATMEKSPKSEVVITTVPLVSEIQLMAATGGTELSCYRCIIPFAVVVFIAGIVVTAVAYSFNSHGSIISIFGLVVLSSGLFLLASSALCWKVRQRSKKAKRRESQTALVANQRSLFA
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
Q9NV29
P39325
YTFQ_ECOLI
Galactofuranose-binding protein YtfQ
Escherichia
MWKRLLIVSAVSAAMSSMALAAPLTVGFSQVGSESGWRAAETNVAKSEAEKRGITLKIADGQQKQENQIKAVRSFVAQGVDAIFIAPVVATGWEPVLKEAKDAEIPVFLLDRSIDVKDKSLYMTTVTADNILEGKLIGDWLVKEVNGKPCNVVELQGTVGASVAIDRKKGFAEAIKNAPNIKIIRSQSGDFTRSKGKEVMESFIKAENNGKNICMVYAHNDDMVIGAIQAIKEAGLKPGKDILTGSIDGVPDIYKAMMDGEANASVELTPNMAGPAFDALEKYKKDGTMPEKLTLTKSTLYLPDTAKEELEKKKNMGY
Part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport (Probable). Binds to both alpha- and beta-galactofuranose .
P39325
Q323B4
SYM_SHIBS
Methionyl-tRNA synthetase
Shigella
MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIMLKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFIKNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSGATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFGFEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVYFHSLFWPAMLEGSNFRKPTNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYYTAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYKTFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQESRDADLQAICSMGINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMRQVEALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLRLTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKDIFLLSPDAGAKPGHQVK
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Q323B4
A5D2S1
RBFA_PELTS
Ribosome-binding factor A
Pelotomaculum
MSFRSERVAEAIKKEVSDMLRNELKDPRIGFVTITSVEVSKDLRYANIYASVFGSPDDQKETIEALKKAQGFIRGELGKRIRLRYTPEITFKLDQSIGRGSRVLALMEEVREKGGGQDE
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
A5D2S1
B9FDE0
BSK3_ORYSJ
Receptor-like cytoplasmic kinase 173
Oryza sativa
MGGRVSKAVACCCCRSQHHGVVVESSEKTAEEDHGESYELPAFQEFSFEQLRLATSGFAVENIVSEHGEKAPNVVYKGKLDAQRRIAVKRFNRSAWPDPRQFLEEAKSVGQLRSKRLANLLGCCCEGDERLLVAEYMPNDTLAKHLFHWEAQAMKWPMRLRVVLYLAEALEYCTSKGRALYHDLNAYRVLFDDDCNPRLSCFGLMKNSRDGKSYSTNLAFTPPEYMRTGRITPESVIYSFGTLLLDVLSGKHIPPSHALDLIRDRNFNMLTDSCLEGQFSNEEGTELVRLASRCLHYEPRERPNVRSLVQALAPLQKDLETPSYELMDIPRGGATSVQSLLLSPLAEACSRKDLTAIHEILEKTGYKDDEGTANELSFQMWTNQMQDTLNSKKKGDNAFRQKDFSSAIDCYSQFIEVGTMVSPTIYARRCLSYLMNDKAEQALSDAMQALVISPTWPTAFYLQAAALLSLGMENEAQEAIKDGCAHETSSSSGH
Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of BRI1.
B9FDE0
B3PMP1
RS3_META1
30S ribosomal protein S3
Metamycoplasma
MGQKVNPNGFRYGITKAHNSVWYADKMQFASHLLEDQKIYDFFDKKVRQLQIGNVQIKRNQNGLILIYVYTAKPAVMLGTNGENIKNLTKDLQKILKNKKANISIQVIELKKPDLNARLLAEDIAIKLENRGSFRLAQKFAIKAALKAGAKGIKTSVSGRLNGVDMARTEGYNEGEMKLHTLRQDVDYAATTAKTTYGILGVKVWVSLGEILSDEQKAKQEEMDLLNAPKDRRVRRGGERHASTKKN
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
B3PMP1
Q8VCK7
SYCN_MOUSE
Syncollin
Mus
MSLLCPLLLALALVAVPGAHGNCPVPADLKKSDGTRTCARLYEKSDPYYDNCCQGPVLSVEPGTDLPYLPSGWSNTASSLVVGQRCEITVWSLPGKHGKTRKFTAGSYPRLEEYRKGIFGDWSDSISALYCKCY
Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues.
Q8VCK7
B0B7N3
RL10_CHLT2
50S ribosomal protein L10
Chlamydia
MKEEKKLLLREVEEKITASQGFILLRYLGFTATHSRSFRNNLSGVSAEFEVLKKKIFFKALETSGVEMDPEDSEGHLGVVFAYGDPVSAAKQVLDFNKQHNDSLVFLAGRIDNASLSGREVEAVAKLPSMKELRQQVVGLIAAPMSQVVGIMNSVLSGVVSCVDQKAEKTQE
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
B0B7N3
Q02294
CAC1B_RAT
Voltage-gated calcium channel subunit alpha Cav2.2
Rattus
MVRFGDELGGRYGGTGGGERARGGGAGGAGGPGQGGLPPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTEILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDAVLKRAATKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKSGKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPGRDGLRGPAGNKSKPEGTEATEGADPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAESTETGAREERARPRRSHSKEAPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGKEGTAPVLVPKGERRARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKESNVVEGDKETRNHQPKEPRCDLEAIAVTGVGSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGEATVVPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIANNFINLSFLRLFRAARLIKLCRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGNRACDPHANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDVLYEARAPLERGHSAEIPVGQPGALAVDVQMQNMTLRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSISTLAPRPHGTQLCNTVLDRPPPSQVSHHHHHRCHRRRDKKQRSLEKGPSLSVDTEGAPSTAAGSGLPHGEGSTGCRRERKQERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQPKPSLSSHPISPTAALEPGPHPQGSGSVNGSPLMSTSGASTPGRGGRRQLPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLASGSRIGSDPYLGQRLDSEASAHNLPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSTGVRARHSYHHPDQDHWC
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals .
Q02294
A8E2V9
PA2B_TRIGS
Phosphatidylcholine 2-acylhydrolase
Trimeresurus
MRTLWIVAVLLVGEGSLIQLWEMIFQEMGKGAAKKYGLYGCNCGMGHRGRPVDATDRCCSVHKCCYKKLTDCDPKTDRYSYSWENGAIVCGGDDPCRKEVCECDKATTICFRDNLDTYDKKYKIYLKFLCKKPEPC
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
A8E2V9
P17692
CDGT_BACS8
Raw-starch-digesting amylase
Bacillus
MKKFLKMTAAFSLGLSLAFGLFSPAQAAPDTSVSNKQNFSTDVIYQIFTDRFSDGNPANNPTGAAFDGTCTNLRLYCGGDWQGIINKINDGYLTGMGVTAIWISQPVENIYSIINYSGVNNTAYHGYWARDFKKTNPAYGTIADFQNLIAAAHAKNIKVIIDFAPNHTSPASSDQPSFAENGRLYDNGTLLGGYTNDTQNLFHHNGGTDFSTTENGIYKNLYDLADLNHNNSTSDVYLKDAIKMWLDLGIDGIRMDAVKHMPFGWQKSFMAAVNNYKPVFTFGEWFLGVNEVGPENHKFANESGMSLLDFRFAQKVRQVFRDNTDNMYGLKAMLEGSAADYAQVDDQVTFIDNHDMERFHASNANRRKLEQALAFTLILARVPAIYYGTEQYMSGGTDPDNRARIPSFSTSTTAYQVIQKLAPLRKSNPAIAYGSTQERWINNDVLIYERKFGSNVAVVAVNRNLNAPASISGLVTSLPQGSYNDVLGGLLNGNTLTVGSGGAASNFTLAAGGTAVWQYTAATATPTIGHVGPMMAKPGVTITIDGRGFGSSKGTVYFGTTAVSGANITSWEDTQIKVKIPAVAGGIYNIKVANAAGTASNVYDNFEVLSGDQVSVRFVVNNATTALGQNLYLTGNVSELGNWDPAKAIGPMYNQVVYQYPNWYYDVSVPAGKTIEFKFLKKQGSTVTWEGGSNHTFTAPSSGTATINVNWQP
This endo-type adsorbable amylase is capable to digest raw starch.
P17692
Q9LZR3
CSLA9_ARATH
Protein RESISTANT TO AGROBACTERIUM TRANSFORMATION 4
Arabidopsis
MELGDTTSVIPDSFMGYRDDITMQMSMVLDQIRAPLIVPALRLGVYICLTMSVMLFVERVYMGIVISLVKLFGRKPDKRFKYEPIKDDIELGNSAYPMVLIQIPMFNEREVYQLSIGAACGLSWPSDRIVIQVLDDSTDPTIKDLVEMECSRWASKGVNIKYEIRDNRNGYKAGALKEGMKKSYVKSCDYVAIFDADFQPEADFLWRTVPYLLHNPKLALVQARWKFVNSDECLMTRMQEMSLDYHFTVEQEVGSSTYAFFGFNGTAGIWRISALNEAGGWKDRTTVEDMDLAVRASLKGWKFLYLGSLKVKNELPSTFKAYRYQQHRWSCGPANLFRKMAFEIMTNKNVTLWKKVHVIYSFFVVRKLVAHIVTFIFYCVILPATVLVPEVTVPKWGAVYIPSVITLLNAVGTPRSLHLMVFWILFENVMSLHRTKATFIGLLEGGRVNEWIVTEKLGDVKAKSATKTSKKVIRFRFGDRIHVLELGVGMYLLFVGCYDAFFGKNHYYLYLFAQAIAFFIAGFGQIGTIVPNH
Possesses glucomannan synthase and mannan synthase activities in vitro. Mannan synthase consists of a 4-beta-mannosyltransferase activity on mannan using GDP-mannose. The beta-1,4-mannan product is the backbone for galactomannan synthesis by galactomannan galactosyltransferase. Galactomannan is a noncellulosic polysaccharides of plant cell wall . Required for lateral root development .
Q9LZR3