accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q12126
CRK1_SCHPO
Mitotic catastrophe suppressor 6
Schizosaccharomyces
MDIEKSDKWTYVKERKVGEGTYAVVFLGRQKETNRRVAIKKIKVGQFKDGIDISALREIKFLRESRHDNVIELVDVFSTKSNLNIILEFLDSDLEMLIKDKFIVFQPAHIKSWMVMLLRGLHHIHSRFILHRDLKPNNLLISSDGVLKLADFGLSRDFGTPSHMSHQVITRWYRPPELFMGCRSYGTGVDMWSVGCIFAELMLRTPYLPGESDLDQLNVIFRALGTPEPEVIKSMQQLPNYVEMKHIPPPNGGMEALFSAAGHEEIDLLKMMLDYNPYRRPTAQQALEHHYFSALPKPTHPSLLPRKGGEEGIKHVSSDL...
Protein kinase essential for cell proliferation, where it is required for completion of cytokinesis. Phosphorylates the C-terminal repeat domain (CTD) of RNA polymerase II.
Q12126
P75507
Y268_MYCPN
Putative PTS system EIIB component
Mycoplasma
MKVLLWIGYVLSFGLLYLYLVKRAKRAALQLNNKLVESHTIPFAVRDFIAACGGRTNFVSLRTSPTQLIVSFAKPELVQIAALQKLGIKGINKSQNQYRFVLGNFVNQLKQQIENER
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.
P75507
Q2YUJ1
GLYA_STAAB
Serine hydroxymethyltransferase
Staphylococcus
MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLRHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGS...
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent a...
Q2YUJ1
Q3TDN0
DISP1_MOUSE
null
Mus
MAVISGSDSVLLSNGSISTSTSNPSPLSPSDGDLPAQHLGPRETPRTKASPNGCLQLNGTVKSSFLPLDNQRTPQTPTQCCHPCPYHHPVSSHSNHQECHPEAGLAASPALASCRMQPHSEYSASLCPNHSPVYQAAHCLQPSPSFCLHHPWPDHFQHQPVRQHLTIIRPSRPFKFPRSYAALLADWPVVVLGMCTLLIVVCALVGVLVPELPDFSDPLLGFEPRGTTIGQRLVTWNNMMRNTGYKATLANYPYKYAEEQARSHRDDRWSDDHHERERREVDWNFQKDSFFCDVPSDGYSRVVFASAGGETLWNLPAIKS...
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion .
Q3TDN0
B1KE86
CYSI_SHEWM
Sulfite reductase [NADPH] hemoprotein beta-component
Shewanella
MSDGKSVEKEEALSVNEHLKTDSDFLRGTIQEGLDTAVTGSFSEGDQQLIKFHGFYQQDDRDLRNERKEQKLEPLYSFMLRARVAGGVCSPEQWLGVDEISSTLTSSNSIRLTTRQTFQYHGISKRNLRTLIQGLDSKALDSIAACGDVNRNVMCNPNPVESRLHEQAYYWAKQLSDQYLPRTKAYAEIWLGDDKVATSEGDDVEPVYGKTYLPRKFKMAVAVPPDNDVDVYTNDLGFVAVAEEGELVGFNLVAGGGMGSTHGEVQTFPRLADDFGFIKAEDTLKFAEAVLKVQRDWGNRSNRKLSRLKYTIVKYGYEAF...
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
B1KE86
Q7SHU9
NNRD_NEUCR
ATP-dependent NAD(P)HX dehydratase
Neurospora
MSSESSTGPEMSATTKQMLARVRQMVPPMLEKFHKGQLGRVAVIGGSEDYTGAPYFSAMASARLGADLSHVICTPNAAQVIKTYSPNLMVHPLMRSSPPALSSSDSGSSPSRTKSAPDTDPSQIAAQIIPMLDRLHVLVIGPGLGRDPLMQETCAKVITAAREKGIPMVLDADALLLVTKDPSLIKGYDNAVLTPNVVEFGRLTKALGVDEEVEKAEETAGETAKVEALAKALGGVMVVQKGAKDYLSDGKVTLTVDLKGGLKRSGGQGDTLTGSIATFLGWRRAYLEDLWDHGHKLNKEELIGLAVFGGSAITRECSRL...
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-depen...
Q7SHU9
A4T6V7
SUCC_MYCGI
null
Mycolicibacterium
MDLFEYQAKELFAKHNVPTTPGRVTDSAEDAKAIATEIGKPVMVKAQVKVGGRGKAGGVKYAATPDDAFTHAQNILGLDIKGHVVKKLLVAEASDIAEEYYISFLLDRSNRTYLAMCSVEGGMEIEEVAATKPDRLAKVPVNAVKGVDLAFAREIAEKGHLPAEVLDAAAVTIQKLWEVFTKEDATLVEVNPLVRTPDDQILALDGKVTLDANADFRQEGHKEFEDKDATDPLELKAKENDLNYVKLDGEVGIIGNGAGLVMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMANGLDVILNDSQVKSVFVNVFGGIT...
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinat...
A4T6V7
Q8D8J3
IHFB_VIBVU
Integration host factor subunit beta
Vibrio
MTKSELIERLCAEQTHLSAKEIEDAVKDILEHMASTLESGDRIEIRGFGSFSLHYREPRVGRNPKTGDKVELEGKYVPHFKPGKELRERVNIG
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
Q8D8J3
Q8EU94
SYE_MALP2
Glutamyl-tRNA synthetase
Malacoplasma
MNKNKIIRTRYAPSPTGLFHIGGARTALFNYLFAKKNNGDFIVRIEDTDIDRNVENGIESQLLNLKWLKIFPDESPLNPGNYGPYIQTERLPIYKEKAEQLLKEKKAYRCFCTPEQLEKNRKKALKDGKTPKYNRTCLSLSEDQISEKIKNNIPFSLRFKITDNTEIKWNDIVRGEMCVPTSALTDPVILKSNGIPTYNFAVVIDDNDMLISHIIRGEEHLSNTPYQIAINEALDINKNIVFGHLSVIIDETGKKLSKRNMELKQFIEDYKNMGFSPEAIVNFMYLLGLSSSDNKEIFSLAEAVKNFDIKKVSKSPTTFD...
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Q8EU94
P01528
NA12_ANESU
Toxin II
Anemonia
GVPCLCDSDGPSVRGNTLSGIIWLAGCPSGWHNCKKHGPTIGWCCKQ
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM) . It has also great ac...
P01528
B2I8G9
RL3_XYLF2
50S ribosomal protein L3
Xylella
MGCYSMGFVGRKAGMSRVFLEDGCSIPVTLIEATANRVVQIKTSDVDGYDAVQVTVGSRRSVLVNKPESGHFAKAKVEAGRGLWEFRVEKTQLGSYSVGSEVGLSIFAVGQKVDIQGITKGKGFQGTIKRHNFRMGDATHGNSLSHRAPGSLGQRQTPGRVFPGKKMSGHMGAVKQSVQNLEVIKIDVERCLIAVRGAIPGASGGDVLIRSASKI
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
B2I8G9
Q7SGT7
QCR9_NEUCR
Ubiquinol-cytochrome c reductase complex 8 kDa protein
Neurospora
MSALYNLIFRNNTAFVGAVFAGAFAFELAYDNGMDKVWDKINKGRQWKDIRHKYVEAEE
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidor...
Q7SGT7
B8FEA3
RL31_DESAL
50S ribosomal protein L31
Desulfatibacillum
MKKDIHPKYETTVIRCACGATVEAGSTVDDLTVEICSQCHPFFTGKQKLVDTAGRIERFRRKYAKFNQAQEAKQDQ
Binds the 23S rRNA.
B8FEA3
Q9KL41
HUTZ_VIBCH
Heme-degrading enzyme HutZ
Vibrio
MDQQVKQERLQGRLEPEIKEFRQERKTLQLATVDAQGRPNVSYAPFVQNQEGYFVLISHIARHARNLEVNPQVSIMMIEDETEAKQLFARKRLTFDAVASMVERDSELWCQVIAQMGERFGEIIDGLSQLQDFMLFRLQPEQGLFVKGFGQAYQVSGDDLVDFVHLEEGHRKISNG
Involved in heme degradation . Catalyzes the degradation of heme to biliverdin, with the release of iron . Forms biliverdin beta and delta . Binds heme with high efficiency .
Q9KL41
A9M392
HPRK_NEIM0
HPr(Ser) kinase/phosphorylase
Neisseria
MPSISVRRLFDDNQYKLQLAWAAGNSGADNRIGVEADKPVLALVGHLNFIHPNQIQVVGLAESEYLNRLESGETGYQFGDLFDISMSLVIVANGLPVSPGLRDYCHKNDIPLLTSKLESPYLMDVLRIYLQRTLAASSVKHGVFLDVFEIGVLITGHSGLGKSELALELISRGHSLIADDAVELFRIGPETLEGRCSPMLRDFLEVRGLGILNIRHIFGETSIRPKKILQLIINLVEADDEYMKQLDRLSIRTETESILNVNVRSVTLPVAVGRNLAVLVEAAVRNYILQLRGKDSTREFLERHQTQLKENEQNHENRPD
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphor...
A9M392
B1XJ13
RRF_SYNP2
Ribosome-releasing factor
unclassified Synechococcus
MQLSELRENMQKTIEATQRSFNTLRTGRASASLLDRITVEYYGAETPLKSLASISTPDSSTIMIQPFDRGSLSDVERAISMSDLGLTPNNDGTNIRLNIPPLTKERRQELVKTAGKLAEEGKVALRNIRRDAIDDVRKQEKNSDISEDESRSLQDDIQKVTDEFTTKIDDLLKIKEKDIMTV
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
B1XJ13
B1ZND0
RL15_OPITP
50S ribosomal protein L15
Opitutus
MKLHELKNVKGAVHRKKRVGCGEGGGHGKTSGRGGKGQTARSGSSIRPGFEGGQMPLYRKLPHRGFNQYNFRTELPVVNVGDLASLDASITEVTAEVLAAQGLIRAGETSVKILGDGELSRALKVTAVKFSESAKAKIEKAGGQAITA
Binds to the 23S rRNA.
B1ZND0
Q8UUI3
PA2BE_LATLA
Phosphatidylcholine 2-acylhydrolase
Laticauda
MYPAHLLLLLAVCVSLLGASAIPPLPLNLAQFALVIKCADKGKRPRWHYMDYGCYCGPGGSGTPIDELDRCCKTHDECYAQAEKKGCYPKLTMYSYYCGGDGPYCNSKTECQRFVCDCDVRAADCFARYPYNNKNYNINTSKRCK
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Q8UUI3
Q2KIC5
ITPA_BOVIN
Nucleoside-triphosphate pyrophosphatase
Bos
MAASLAGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIRKCQEAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLEGFQDKSAYALCTFAFSTGDPNEPVRLFRGRTMGRIVVPRGCRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFRALLALQEYFSSLTPGVGDDHPSWGSGEG
Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between ...
Q2KIC5
Q7MYB3
TPIS_PHOLL
Triose-phosphate isomerase
Photorhabdus
MRHPLVMGNWKLNGSTHMVNELITGLRQELSSVTGCDVAIAPPALYLSQAKQALAGSRIALGAQDVDVNLSGAFTGETSATMLKDIGAEYIIIGHSERRTYHQESDEFIAKKFAILKQQGLIPVLCIGETEQENEAGQTESVCARQIDAVLNTLGVAAFQGAVIAYEPVWAIGTGKSATPAQAQAVHKFIRDHIAQKDAAIAQQIIIQYGGSVNADNAAELFSQPDIDGALVGGASLKANAFAVIVKAAAAAKKA
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q7MYB3
D6R8X8
HYUP_MICLQ
Sodium-hydantoin transporter Mhp1
Microbacterium
MNSTPIEEARSLLNPSNAPTRYAERSVGPFSLAAIWFAMAIQVAIFIAAGQMTSSFQVWQVIVAIAAGCTIAVILLFFTQSAAIRWGINFTVAARMPFGIRGSLIPITLKALLSLFWFGFQTWLGALALDEITRLLTGFTNLPLWIVIFGAIQVVTTFYGITFIRWMNVFASPVLLAMGVYMVYLMLDGADVSLGEVMSMGGENPGMPFSTAIMIFVGGWIAVVVSIHDIVKECKVDPNASREGQTKADARYATAQWLGMVPASIIFGFIGAASMVLVGEWNPVIAITEVVGGVSIPMAILFQVFVLLATWSTNPAANLL...
Nucleobase-proton symporter that mediates the sodium-dependent binding and uptake of 5-aryl-substituted hydantoin compounds . 5-indolyl methyl hydantoin and 5-benzyl hydantoin are the preferred substrates, with selectivity for a hydrophobic substituent in position 5 of hydantoin and for the L isomer over the D isomer .
D6R8X8
Q9F4I7
PYRR_PSEFL
Uracil phosphoribosyltransferase
Pseudomonas
MSLPNPAELISQMAIRLKAHLEHRGISDPRYIGIRTGGVWVAQALLEALGSQSPLGTLDVSFYRDDFSQNGLHPQVRPSALPFEIEGQHLVLIDDVLMSGRTIRAAMNELFDYGRPASVTLVCLLDLDAAELPIRPNVVGATLTLAAHERVKLSGPSPLQLELQDLAL
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
Q9F4I7
A4WNI9
RLMN_CERS5
tRNA m2A37 methyltransferase
Cereibacter
MTATAPITQDVMTLPRKLPEGGPLNIVGLTREELMAALVAAGTPERQARMRMGQVWQWVYHWGVRDFAQMTNLAKDYRALLAEHFAIVLPEVVTRQISADGTRKYLIRIAGGHEVETVYIPEEGRGTLCVSSQVGCTLTCSFCHTGTQKLVRNLTAGEIVGQVMLVRDDLGEWPERGAPKDETRLVSNLVLMGMGEPLYNFENVRNAMKVVMDGEGLSLSRRRITLSTSGVVPEIARTAEEIGCQLAISFHATTDEVRDILVPINKRWNIRTLLDSLRDYPRLSNSERITFEYVMLDGINDSDADARRLVKLISGIPSKI...
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
A4WNI9
C8VK14
HXNY_EMENI
Nicotinate catabolism cluster protein hxnY
Aspergillus subgen. Nidulantes
MAPTAPPILDFSPFYGTDGAAKAKLVQQVRESCEYNGFFQITGHRIPRELQVRVMDAAKRFFALPLEEKMAIDKNLNSFNRGYELLRSQMLEVGTAPELKEGLYIGEEIGADHPYYINGRLNSGPNQWPATVPDAQEFRETSMEYYHAVYELAKDVLAVLALTLDVEESFFDPLTEGGVATMRMLHYPSQPKDEDEKLNRGIGAHTDFGCITLLLQDEVDGLQVLDAPSGQWLDVQPVLGAYVVNLGDLMMRMANDRYKSNIHRVINKSGRERYSIPFFFSGNPDHVCKCLPNCCKAGEQPKYPPITVEDMVRGAYKQSY...
2-oxoglutarate-Fe(II) type oxidoreductase, part of the hnx cluster involved in the purine degradation . The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism . The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of n...
C8VK14
A4JBL2
RUVB_BURVG
Holliday junction ATP-dependent DNA helicase RuvB
Burkholderia cepacia complex
MIETDKLAAERIIAATPASSHEEVFERALRPRQLDDYVGQEKVRGQLEIFIEAAKRRSEPLDHVLLFGPPGLGKTTLAHIIAREMGVNLRQTSGPVLERAGDLAALLTNLEANDVLFIDEIHRLSPVVEEILYPALEDYQIDIMIGEGPAARSVKLDLQPFTLVGATTRAGMLTNPLRDRFGIVARLEFYDAEQLSRIVRRSAALLNAQIDPNGALEIAKRSRGTPRIANRLLRRVRDYAEVKADGQITAAVADAALAMLDVDPVGFDLMDRKLLEAILHKFDGGPVGIDNLAAAIGEERDTIEDVLEPYLIQQGFLQRT...
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
A4JBL2
Q0TNI5
OBG_CLOP1
GTP-binding protein Obg
Clostridium
MFIDTAKIFVKSGDGGHGSVSFRREKYVPLGGPDGGDGGKGGDVTFVVDPGMTTLLDFKYKRKFVAGRGQDGQGSKCYGRDGENLTIKVPMGTIIRDVETNKVMADLSHRDDTYTICRGGKGGKGNCKFCTPTRQAPTFAEPGMPGEERWVALELKLLADVGLLGFPNVGKSTLLSVVTKAKPKIANYHFTTLKPNLGVVAVPGIEPFVMADVPGIIEGASEGVGLGLDFLRHIERTRLLIHVVDISGVEGRDAVEDFKRINEELKNYSVKLWDRPQIVVANKCDMLFDEEIFENFKAEVNKMGFDKVFKMSAATSQGVE...
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Q0TNI5
A3LVM9
MTNB_PICST
Methylthioribulose-1-phosphate dehydratase
Scheffersomyces
MSSSCFCKHSEETPLSVLSPELQEQFSDPNHPANLICELCRLFYDNNWVTGTGGGISIRDVDGANPNLVYIAPSGVQKERIQPWEMFLVELPEEKILRTPNDIPKELTKSYKYKPSACTPLFMSCYTMRDAGACIHTHSQHAVMVTLFLEGKKEFEISHIEQIKALPKLALNENTGKIEKIGSMEYYDKLVIPIIENTPHEEDLTDSLQEAIKNYPGTSAVLVRRHGIYVWGETVWKAKVYNEAIDYLLELAVKMQQSGIPTVKQ
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
A3LVM9
C4K175
NDK_RICPU
Nucleoside-2-P kinase
spotted fever group
MTIQYTFSMIKPDAIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAACFYDEHRARPFFNSLVEYITSGAVVLQVLKGEDAITLNRTVMGATNPAEAEAGTIRKDLGESIEANSIHGSDSENSAKREIAFFFNKSEIIE
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
C4K175
A0Q0R4
DXR_CLONN
2-C-methyl-D-erythritol 4-phosphate synthase
Clostridium
MKNICILGATGSIGTQTLDVIEKESNKFKLVAFSANKSYEKIITIIEKFNPVYGAINDKETFLKVKDHCNINNIKINLLYGMDGLIKISTLEEVELVVTSIVGMIGLVPTLEAINAGKDIALANKETLVTGGELVMKAAKQNNVKILPVDSEHGAIFQCLQGNSYKDIETIYVTASGGPFRQSKLEELINITPEQALKHPKWNMGKKISIDSSTMINKGLEVIEAHWLFNVGYDKIKVLVHPQSIVHSMVEYIDGSIIAQLASTDMRLPIQYALNYPVRNKKVVEKLDVYNMGNLTFEKPDFEKFRGLKLAYEAGKLGGI...
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
A0Q0R4
P06796
CASK_MOUSE
Kappa-casein
Mus
MMRNFIVVVNILALTLPFLAAEIQNPDSNCRGEKNDIVYDEQRVLYTPVRSVLNFNQYEPNYYHYRPSLPATASPYMYYPLVVRLLLLRSPAPISKWQSMPNFPQSAGVPYAIPNPSFLAMPTNENQDNTAIPTIDPITPIVSTPVPTMESIVNTVANPEASTVSINTPETTTVPVSSTAA
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
P06796
A0R8J2
RL5_BACAH
50S ribosomal protein L5
Bacillus cereus group
MNRLKEKFQKEITPALVSKFNYKSVMQVPKIEKIVINTGVGDAVSNSKALDNAVEELTQITGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGEQMYEFFDKLVSVSLPRVRDFRGVSKKSFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTAKTDEEARELLTQFGMPFQK
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement...
A0R8J2
C6C179
RPOB_MARSD
Transcriptase subunit beta
Maridesulfovibrio
MGQLRKIFGKIKVTLPIPHLLELQVDSFKKFLQEGVAPASRADVGLEGVFRSVFPIEDFNKTASLEYVSYDIGEPKYDMDECISKGLTYEAPIRIKVRLVVFDVDEETESRTIRDIKEQDIYFGTVPLMSEQGTFIINGTERVIVNQLQRSPGIIFEHDSGKTHTSRKVLYSCRIIPMRGSWLDFDFDHKDILYVRIDRRRKMPATVLLKAMGLSKQDILDYYYDVEEYQIDRHIVRRKVVENQYRKENAWVDLCLEDGKVIVARDKQITKFGWKKLVRGGVEYIEVDPKSLVGQFAFNDITDPDTGEVIAEAADEITEE...
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
C6C179
A3MX27
PYRE_PYRCJ
Orotate phosphoribosyltransferase
Pyrobaculum
MKALIDAGVVKFGRFVLSSGIESPFYVDLRRALGHPDLVKWVVSGYLSALSRLKFDVLLGVATGGIPYASILGYLLQKPFGYVRAGAKGYGTMQAVEGADVAGLAAVVVDDVLTTGNSLINAIKAVREAGGEVVGALVFLDREQCGSQNVRRETGVEVFSVYKMRELLETLKPYIGEGHYRAAVEYLAKWSC
Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
A3MX27
Q9T7L5
CYB_MICXA
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Microtus
MTVIRKKHPLIKIINHSFIDLPTPSNISSWWNFGSLLGLCLIVQILTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGVYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPTGLNSDADKIPFHPYYTMKDFLGALILLMALMILTLFFPDILGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALMPLLHTSKQRTLTFRPI...
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is...
Q9T7L5
Q7TQK5
CCD93_MOUSE
Coiled-coil domain-containing protein 93
Mus
MGLPKGPEGQGLPEVETREDEEQNVKLTEILELLVAAGYFRARIKGLSPFDKVVGGMTWCITTCSFDVDVDLLFQENSTIGQKIALSEKIVSVLPRMKCPHQLEPHQIQGMDFIHIFPVVQWLVKRAIETKEEMGDYIRSYSISQFQKTYSLPEDDDFIKRKDKAVKTVVGLSDAYKPRRKYRRQRGAEELPDEESRVHSTLLEYGRRYGFSRQSKTEKAEDKKTALAAGLSAAEKVDAHEEDELQAAEEQRIQSLMTKMTAMANEESRLTASSVGQIVGLCSEEIKQIVSEYAGKQSELSAEESPEKLGTSQLHQRKVI...
Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos s...
Q7TQK5
P94413
YCLJ_BACSU
Uncharacterized transcriptional regulatory protein YclJ
Bacillus
MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEENWDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPFSPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEFDLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVWGVGYKFDED
Could be member of the two-component regulatory system YclK/YclJ.
P94413
A8MIX7
NAGB_ALKOO
Glucosamine-6-phosphate isomerase
Alkaliphilus
MIIHVEENYEAMSKKAALIVASQVVSNPAGVLGLATGSTPAGMYKELVDLFKEGIIDFSQITTFNLDEYYGLPKTNESSYYTYMMENLFNHINVPLERVHIPNGMAEDVEKECLAYEEKIRNAGGIDLQILGIGANGHIGFNEPDHKLSMKTHLVELTEKTIQDNSRFFQKEEDVPTKALSMGIGTILGAKKIILMANGKNKAEAIKEMTNGYLNPMVPASMIQAHPDVILIIDKEAASLL
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
A8MIX7
P68242
GLHA_COTJA
Thyrotropin alpha chain
Coturnix
MDCYRKYAAVTLTILSVFLHLLHTFPDGEFLMQGCPECKLGENRFFSKPGAPIYQCTGCCFSRAYPTPMRSKKTMLVPKNITSEATCCVAKAFTKITLKDNVKIENHTDCHCSTCYYHKS
Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
P68242
A1K783
CLPP_AZOSB
Endopeptidase Clp
Azoarcus
MNAGTPQHSSAWDPVGLGLIPMVVEQSGRGERSYDIYSRLLKERVVFLVGPVNDVTANLIVAQLLFLESENPDKDIYFYINSPGGSVTAGLAIYDTMQFIKPNVSTLCIGQAASMGAFLLAAGEKGKRFCLPNSRVMIHQPLGGFQGQASDIEIHAREILYLRERLNGMLAKHTGQTIEQIEKDTDRDNFMSATAAVEYGLVDKVLTSRADT
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
A1K783
Q7WJ63
KTHY_BORBR
dTMP kinase
Bordetella
MTPRGRFITLEGVDGAGKSTHTAWMVQALRDLGLTVLATREPGGTPVGEKLRELLLSEPMALETETLLMFAARCEHVREVIAPALARGEWVVCDRFTDASYAYQGGGRQLGAARVAALEQWVHPDLQPDRTWLFDVPLDVARARLARSRQLDRFEREEDAFFERTRAAYHERARSSDGRIRIIDSSRPLEVVRAQLDSEVRELVAQAA
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Q7WJ63
Q96HE9
PRR11_HUMAN
Proline-rich protein 11
Homo
MPKFKQRRRKLKAKAERLFKKKEASHFQSKLITPPPPPPSPERVGISSIDISQSRSWLTSSWNFNFPNIRDAIKLWTNRVWSIYSWCQNCITQSLEVLKDTIFPSRICHRELYSVKQQFCILESKLCKLQEALKTISESSSCPSCGQTCHMSGKLTNVPACVLITPGDSKAVLPPTLPQPASHFPPPPPPPPLPPPPPPLAPVLLRKPSLAKALQAGPLKKDGPMQITVKDLLTVKLKKTQSLDEKRKLIPSPKARNPLVTVSDLQHVTLKPNSKVLSTRVTNVLITPGKSQMDLRKLLRKVDVERSPGGTPLTNKENME...
Plays a critical role in cell cycle progression.
Q96HE9
Q55FT4
TSUA_DICDI
Tsunami
Dictyostelium
MDDDYKLIGQIGEGSFGKVYKYRKKFTGQLVACKVISKKGKNEEDILSLRQEIDILKNLSHPNIIQFISCFENKNEFTLVTEYADGDLSQIISEEKTLSVDLIQSICYQLVIALNYLHYKKVIHRDIKPQNILITSGGQIKVCDFGFAKTISSNSILLTSLKGTPLYLAPEIIQEQPYDYKADLWSLGIILYQILVGSPPFSANSLADLVHMTLESNIEIPKELNKYPDLVSLFRQLLCKNPDKRIGWPDLLYHPFVKSYNGAHVINNNNLNYNNNNNNNNNNNNNNNNGNRPITSAGGNYLNDNSSSPSISSPIQSLPL...
Plays a role in chemotaxis and seems to be involved in polarization.
Q55FT4
Q00765
REEP5_HUMAN
Protein TB2
Homo
MSAAMRERFDRFLHEKNCMTDLLAKLEAKTGVNRSFIALGVIGLVALYLVFGYGASLLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSPSNGAELLYKRIIRPFFLKHESQMDSVVKDLKDKAKETADAITKEAKKATVNLLGEEKKST
Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
Q00765
Q5JF03
CRCB_THEKO
Putative fluoride ion transporter CrcB
Thermococcus
MNLRIAMAIALGGAFGAVARFYISGLLPVYRDFPVGTLMVNSIASLILGYLYGLLFWGFDVPPDWRAFFGTGFCGALSTFSTFSYETFSLLREREYLIATLNILANVIITIALVFAGFMLARR
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Q5JF03
Q9KHS2
SSUD_PSESP
FMNH2-dependent aliphatic sulfonate monooxygenase
Pseudomonas
MSLNIFWFLPTHGDGKYLGTSDGARAVDHGYLQQIAQAADRLGFGGVLIPTGRSCEDSWLVAASLIPVTERLKFLVALRPGIISPTVAARQAATLDRLSNGRALFNLVTGGDPDELAGDGLHLNHQERYEASVEFTRIWRKVLEGENVDYDGKHIQVKGAKLLYPPVQQPRPPLYFGGSSEAAQDLAAEQVELYLTWGEPPAAVAEKIAQVREKAAAQGREVRFGIRLHVIVRETNEEAWAAADRLISHLDDDTIARAQASLARFDSVGQQRMAALHGGNRDNLEVSPNLWAGVGLVRGGAGTALVGDGPTVAARVKEYA...
Catalyzes the desulfonation of aliphatic sulfonates.
Q9KHS2
P34683
LIN31_CAEEL
Abnormal cell lineage protein 31
Caenorhabditis
MPRPGKDSYDEQKPPYSYIWLTYMAIQDSDDKMLPLTEIYKYIMDRFPFYRKNTQRWQNSLRHNLSFNDCFIKIPRRADRPGKGSYWAVHPNASGMFENGSCLRRRKRFRARGGQDDDDDDFHHPAPSKISRKNPLPLLPEPPITPPLLSSLFPNLPPSLPNFCLFPPGMDPTKSLLLNPLSLLLMPHFLKNSSNFESSTPHSETSEISGSGSSSSKTPTPEAGFNSSFSIESILSS
Lin-31 regulates how vulval precursor cells choose their fate. It helps specify three alternative cell fates in vulval development.
P34683
B1Y0H7
TRMD_LEPCP
tRNA [GM37] methyltransferase
Leptothrix
MRFDVLTLFPELFEPFLHAGVTRRAFESGQVDVKLWQLRDFAEDNYKRVDDRPYGGGPGMVMLVEPLERALRAVRAQAGDAAPLIHFTPAGAPMTQKRVRELAAGPGAVLLCGRYEGIDQRFISRHVDEEISLGDFVLSGGELPALALLDAVTRLQPGVLNDAASHQQDSFSDGLLDCPHYSRPERLGEAAADAVPAVLLSGHHARVASWRREQQLRITALRRPDLIDAARAAGALSPADERLLASLQL
Specifically methylates guanosine-37 in various tRNAs.
B1Y0H7
Q6EYH8
PSBN_HOUCO
Protein PsbN
Houttuynia
METATLVAISISGLLVSFTGYALYTAFGQPSEQLRDPFEEHGD
May play a role in photosystem I and II biogenesis.
Q6EYH8
Q9SKC3
ARI9_ARATH
RING-type E3 ubiquitin transferase ARI9
Arabidopsis
MDFSDDDMIDNKSGEENYSYGGGNESDDYNDVVDTIIPSEKSYVILKEEDILKLQRDDIERVSSILSLSQVEVIVLLLHYNWCVSKVEDEWFTDEERIRKAVGLLKEPVVDFNGGEKDKKCRKVNIQCGICFESYTREEIARVSCGHPYCKTCWAGYITTKIEDGPGCLRVKCPEPSCSAAVGKDMIEDVTETKVNEKYSRYILRSYVEDGKKIKWCPSPGCGYAVEFGGSESSSYDVSCLCSYRFCWNCSEDAHSPVDCDTVSKWIFKNQDESENKNWMLANSKPCPECKRPIEKNDGCNHMTCSAPCGHEFCWICLKA...
Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.
Q9SKC3
A8ALR4
CAIA_CITK8
Crotonobetainyl-CoA dehydrogenase
Citrobacter
MDFNLNDEQELFVAGIRELMASENWEAYFAECDRDSVYPERFVKALADMGIDSLLIPEEHGGLEAGFVTVAAVWMELGRLGAPTYVLYQLPGGFNTFLREGTQEQIDKIMAFQGTGKQMWNSAITEPGAGSDVGSLKTTYTRKNGKVYLNGSKCFITSSAYTPYIVVMARDGASPDKPIYTEWFVDMSKPGIKVNKLEKLGLRMDSCCEINFDDVELDEKDMFGREGNGFNRVKEEFDHERFLVALTNYGTAMCAFEDAARYANQRVQFGETIGRFQLIQEKFAHMAIKLNSMKNMLLEAAWKADNGTITSGDAAMCKYF...
Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
A8ALR4
M3APK4
PK81C_PSEFD
PKS8-1 gene cluster protein MYCFIDRAFT_34418
Pseudocercospora
MKSDTQVRAPTPKVGKQATAVTLGAFLSGAMMSLSAVMIPVVLQTNDQADQLLKQWALLYHYGHIIMPSLAILTTSLYAYIAYSKRAVGHQDWSAYAKAGLTTIAIVPFTLTIMEPTNDTLHELSRSTGNSLDIVQGLIVKWVWMHTVRSVFPMFGSILGFRGVLKECGVYSK
Anthrone oxygenase; part of the gene cluster that mediates the biosynthesis of an emodin derivative that may be involved in black Sigatoka disease of banana . The pathway begins with the synthesis of atrochrysone thioester by the polyketide synthase PKS8-1 (Probable). The atrochrysone carboxyl ACP thioesterase MYCFIDRA...
M3APK4
Q98TT6
4EB3L_DANRE
Eukaryotic translation initiation factor 4E-1A-binding protein
Danio
MSTNTQQSKSCPIPTRVLHLKDWSQLPDCYSQTPGGTLFSTTPGGTRIIYDRKFLLDCRNSPIARTPPCCLPQIPGVTIPSLHPVSKLQELKEELEEEKELAADDSQFEMDI
Regulates eif4e1a activity by preventing its assembly into the eIF4F complex.
Q98TT6
Q47K96
RS18_THEFY
30S ribosomal protein S18
Thermobifida
MAKPPVRKPKKKVCVFCQEKMTYVDYKDTTLLRKFISDRGKIRARRVTGNCTQHQRDVAKAVKNAREMALLPYTSSAR
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Q47K96
C1AB49
ENGB_GEMAT
Probable GTP-binding protein EngB
Gemmatimonas
MVIRHLEYLGPMATIDGWRPEITLPEIAFVGRSNVGKSSLLNKLMRRKSFARVSTTPGRTREIHFFDVNHQFVLADLPGYGYARISKERKAEWRPLIEGYLGTSPRLQGVVQLLDVRHDPTNDDYVMMDFLADVGVPTIVAITKIDKLKPAQARARVEELSKRLGLDADQVVPFSAHTGAGRDELASALMQLLAMPDWRTTEEE
Necessary for normal cell division and for the maintenance of normal septation.
C1AB49
A9BHK9
HCP_PETMO
Prismane protein
Petrotoga
MEMFCYQCQETLRNEACVAQGVCGKSPETANLQDLLIYVLKGISYWANKARELNVEDESVDLFVAEGLFVTITNVNFDEGRIVEYIDEAVDKRRIIENKFKEVYEKKYNEKFQEKVPDAAVWNPKDNNEDEYLNKAVEVGVLSESDEDIRSLKNFLVIGLKGVAAYTDHAYILKHSNDDILAFIEKALAETLREDITVDELMNLVLKIGEYGVNAMALLDEANTSTFGNPEITQVYTGTYETPAILVSGHDLLDLYEILEQTKGKGIKVYTHGEMLPANAYPGLKKYEHLAGNFGGSWWKQQQEFEDFGGAVVMTTNCIQ...
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
A9BHK9
O85762
SSUE_PSEPU
FMN reductase
Pseudomonas
MLVVSIGGSPSTRSRSGVLLERSRQWLQDRGVEVVSFQVRDFPAEDLLHARFDSPQVQHFQQLVAQADGLVVATPVYKASFAGALKTLLDLLPERALEHKIVLPIATGGSIAHMLAVDYALKPVLSALKAQETLQGIFADDSQIAYGEGAKPAQLAPALEERLHDSLETFHVALARRPRPVAPGVLNERLISARWSI
Probably forms a two-component reduced flavin mononucleotide-dependent monooxygenase by binding to SsuD. Required for growth on aliphatic sulfonates or methionine but not arylsulfonates.
O85762
Q7S332
KYNU1_NEUCR
L-kynurenine hydrolase 1
Neurospora
MSDFTSKVKVLRDGQKPEFPSNANTLEYAQSLDAQDELRHFRNEFIIPTRASLKKKALDGIIPGTQANGTTTSTDADTPCIYFVGNSLGAQPKAVRHYLEAQLETWASIGVNGHFSSLSNSPLTPWQDMAADCAAKSAAIVGAADPSEVVIMNTLTVNLHFMMASFYRPTDKRHKIILEWRPFPSDWYAFQSQIEWHGLDPEKSIVEMQPDENLYLSTEKILATIDEHAEDAALLLLPGIQYYTGQLFDIPRITKYAQERGIVVGWDLAHCAGNVELQLHDWNVDFAVWCTYKYLNGGPGSMAGAFVHERHGKVDMSLGK...
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Q7S332
A9IIK3
AMPA_BORPD
Leucyl aminopeptidase
Bordetella
MEFSTQSTASLHQIKTAALAVGVYADGELSPAADVIDRASNNAVRQVVKAEFRGRPGATLVLRALPGVSAQRVVLVGLGKQSEYNARAHAAAEQGFAAACVAARITEAVSTLAANSIADTPIRARARSAAIAAGAATYHYDATFGKPDRDARPKLKKIVQVVERGEAAQTQQGLREGSAIAHGMELTRTLGNLPGNVCTPTYLGDTARKLAREFKSLKVEVLDRKQVEALGMGSFLSVARGSDEPLRFIVLRHAGKPAKKSKAGPVVLVGKGITFDAGGISLKPAATMDEMKYDMCGAASVLGTFRALAELELPLDVVGL...
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
A9IIK3
A6VKS7
RBSD_ACTSZ
D-ribose pyranase
Actinobacillus
MKKTTIINAQLSYAIATLGHTETLTLCDAGLPIPNSSNRIDLALTKGIPSFLETLYAVTSEMFVERAILASEIKEKNPEILTALLAHLSQLATKQGNQIPVEFVSHEKFKKLTHDSKGIVRSGECSPYANIILVSGVPF
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
A6VKS7
O70536
SOAT1_RAT
Cholesterol acyltransferase 1
Rattus
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAM...
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrateb a higher activity towards an acyl-CoA substrate with a double...
O70536
C0MFZ1
HSLO_STRS7
Heat shock protein 33 homolog
Streptococcus
MDKLIKTISASGAFRAYVLDCTETVRYAQERHHTLSSSTVALGRTLIANQILAANQKGDSKVTVKVIGDSSFGHIISVADTKGHVKGYIQNPGVDIKKTATGEVLVGPFMGQGHFVTITDYGTGNPYTSTTPLITGEIGEDLAYYLTESEQTPSAVGLNVLLDQEDKVKVAGGFMLQVLPGASDEEISHYEKRIQEMPAISTLLASENHIDALLAAIYGEEPYKRLAEEQLSFQCDCSKERFASALMNLPTADLQAMRDEDQGAEIVCQFCGIKYQFTEADLEVLINDKA
Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.
C0MFZ1
Q2YJ77
VIRB7_BRUA2
Type IV secretion system putative lipoprotein virB7
Brucella
MKKVILAFVATAFLAGCTTTGPAVVPVLDGKPRVPVNKSVPAKPPLAQPNPVDTYED
The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.
Q2YJ77
P93407
SODCP_ORYSJ
Superoxide dismutase [Cu-Zn], chloroplastic
Oryza sativa
MQAILAAAMAAQTLLFSATAPPASLFQSPSSARPFHSLRLAAGPAGAAAARALVVADATKKAVAVLKGTSQVEGVVTLTQDDQGPTTVNVRVTGLTPGLHGFHLHEFGDTTNGCISTGPHFNPNNLTHGAPEDEVRHAGDLGNIVANAEGVAEATIVDKQIPLSGPNSVVGRAFVVHELEDDLGKGGHELSLSTGNAGGRLACGVVGLTPL
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
P93407
B2VIR2
MTNC_ERWT9
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Erwinia
MIRAIVTDIEGTTSDIRFVHNVLFPYARENLPSFIIGNQQQPAVAQALDQLRAEVERPEATVQELIDVLFGFMDEDRKSTALKALQGMVWRDGYLNGSFTGHLYPDVLPALRRWQQQGLALYVYSSGSVAAQKLLFGYSDAGDITGLFSGYFDTHMGAKREVDAYRNIASQIGLPAEQLLFLSDIHEELDAARDAGWHTVQLIRGAADNASRHRQVTDFDRINQELLNS
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
B2VIR2
Q04638
ITT1_YEAST
Translation termination inhibitor protein ITT1
Saccharomyces
MALTQFENDLEILRDMYPELEMKSVKVEEEGEFPQRINGKLLFKISLLADVNIEFGEQHMLLSNLSNECVEFTIYSCHYPDIRRCVVMDIKSLWISTDEKKMLIDKALRLVEETVDMSIEFADSFTSILILIFGFLIDDTAILLFPNGIRKCLTQDQYDLFKQISEEATLQKVSRSNYHCCICMEMEKGVRMIKLPCENANVEHYLCRGCAKSYFTAMIQENRISSVRCPQCEYKELKLEDFKSYKKMLKALFTPLIPVSFLKEVIDTELCERYEKMFYNQAATRLSKYCPYACVTCRRCDSWCTKEDLDDAMIQCQKCH...
Modulates the efficiency of translation termination, resulting in the readthrough of all three types of nonsense codons UAA, UAG and UGA.
Q04638
P25076
CY11_SOLTU
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit 1
Solanum
MSLGKKIRIGFDGFGRINRFITRGAAQRNDSKLPSRNDALKHGLDGLGSAGSKSFRALAAIGAGVSGLLSFATIAYSDEAEHGLECPNYPWPHEGILSSYDHASIRRGHQVYQQVCASCHSMSLISYRDLVGVAYTEEETKAMAAEIEVVDGPNDEGEMFTRPGKLSDRFPQPYANEAAARFANGGAYPPDLSLITKARHNGQNYVFALLTAYRDPPAGVSIREGLHYNPYFPGGAIAMPKMLNDGAVEYEDGIPATEAQMGKDVVSFLSWAAEPEMEERKLMGFKWIFVLSLALLQAAYYRRLRWSVLKSRKLVLDVVN
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidor...
P25076
Q9ZQ47
GRDP1_ARATH
Glycine-rich domain-containing protein 1
Arabidopsis
MDKEKDHEVEWLEAQKIEISVDLLAAAKQHLLFLETVDRNRWLYDGPALEKAIYRYNACWLPLLVKYSESSSVSEGSLVPPLDCEWIWHCHRLNPVRYNSDCEQFYGRVLDNSGVLSSVDGNCKLKTEDLWKRLYPDEPYELDLDNIDLEDISEKSSALEKCTKYDLVSAVKRQSPFYYQVSRSHVNSDIFLQEAVARYKGFLYLIKMNRERSLKRFCVPTYDVDLIWHTHQLHPVSYCDDMVKLIGKVLEHDDTDSDRGKGKKLDTGFSKTTAQWEETFGTRYWKAGAMHRGKTPVPVTNSPYASDVLVKDPTAKDDFQ...
Plays a regulatory role in abscisic acid (ABA) signaling and tolerance to abiotic stress during germination. May be involved in the regulation of the ABI transcriptional factors.
Q9ZQ47
P30939
5HT1F_HUMAN
Serotonin receptor 1F
Homo
MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCD...
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, su...
P30939
Q21G19
CHED_SACD2
Probable chemoreceptor glutamine deamidase CheD
Saccharophagus
MLKGLTSKADARLKPALPGFTNVYRYWDARFAKVAVKLQPGECYVTKNDEMLVTVLGSCIAACIRDPVAGVGGMNHFMLPEQAAGHEITRNSLSNPELCYGNWAMEHLINSIIKCGGMRNRLEIKLFGGGRVLANMVRMDIGQRNIEFVESFLANDELPVIAKDLGGNYPRKILYFAATGQAKMKKMGIASDTNLVKQEKAYLDSLATKPSAGDVELF
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
Q21G19
A5UCX1
MRAY_HAEIE
UDP-MurNAc-pentapeptide phosphotransferase
Haemophilus
MLVWLAEYLVRYETAFNAISYITVRAILTLLTALFISLWIGPKVIKRLQILKFGQEVRNDGPESHFAKKGTPTMGGVMILFSIGVSTLLWANLANPYIWVCLFVLFGYGAIGFVDDFRKITRKNTDGLIARWKYFWMSVVALVAILWLYWLGHDTDATRLVIPFFKDIMPQLGLFYIVLSYFVIVGTGNAVNLTDGLDGLAIMPTALVAGAFALIAWATGNVNFAEYLHIPYIKYSSEVVVFCTAIVGASLGFLWFNTYPAQVFMGDVGSLALGGALGVVAILVRQEFLLVIMGGVFVVEALSVILQVGSYKLRKQRIFR...
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I...
A5UCX1
Q97WG9
MRE11_SACS2
DNA double-strand break repair protein Mre11
Saccharolobus
MVQILHISDTHLGKRQYSLVEREKDIYDIFSQLVDIAIKEHVDVIIHSGDLFDVSSPTTNALVMAIKILKRLKDVNIPFLSIPGDHDTPKRKGYLIPHNILSELDLIKILNYEKPYIIKGIEVYGIPHIPTVSKSILVSALSALRPKSSRSILLLHQGVKQILPYDGSWQMELGSLPKGFGYYALGHIHTRWRLTQDDGSVIAIAGSPDIMREEEIEGYEKFGKGAYLIDFSKDLPILSTINITVRPQKVVTINTKNIKKDILTIRDDLIEHNKSENNKPILHIIVEGERMRKDLLYKELLPLNDVALYYRIYKDETTQT...
Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endo...
Q97WG9
A7Z4G7
PYRR_BACVZ
Uracil phosphoribosyltransferase
Bacillus amyloliquefaciens group
MNQKAVILDEQAIRRALTRIAHEMIERNKGMNDCILVGIKTRGIYLAKRLAERIEQIEGNPVTVGEIDITLYRDDLTKKTSNEEPLVKGADIPADITDQKVIVVDDVLYTGRTVRAAMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKAEKVMVQLSEVDQTDMVAIYENE
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
A7Z4G7
Q54BK0
NFX1_DICDI
Transcriptional repressor NF-X1 homolog
Dictyostelium
MEESQNIPPKTQTLNNSENSINNINNNNLTTTTTTTAVGNTNYKNNNRYNNNRYNRNNFNNYNNNNNNNNNNNNMVTSTTSPPTTTTTTTSTTTTATPSSNSNNRRKNYHNNNYNNNNNNNQLSEDTDEVILYTPADISASLKSESAKQQQQQQQQSLPTQEPTQTLNWQQELYKLNPKSKAFVPKPQGSVPFNNTNNNNNNNNNNNNNVPQSPIKDNNRPQRERRERKPKENNTQQPQPQQPQQPQQPQPQPQQQQQSQQQQTVKENNRKKENKLQSKKDIITNNDNIEPIKSKEDISLANKFAKNRAKENLAKTNSIN...
May play a role in transcription regulation.
Q54BK0
A7X1D8
SYI_STAA1
Isoleucyl-tRNA synthetase
Staphylococcus
MDYKETLLMPKTDFPMRGGLPNKEPQIQEKWDAEDQYHKALEKNKGNETFILHDGPPYANGNLHMGHALNKILKDFIVRYKTMQGFYAPYVPGWDTHGLPIEQALTKKGVDRKKMSTAEFREKCKEFALEQIELQKKDFRRLGVRGDFNDPYITLKPEYEAAQIRIFGEMADKGLIYKGKKPVYWSPSSESSLAEAEIEYHDKRSASIYVAFDVKDDKGVVDADAKFIIWTTTPWTIPSNVAITVHPELKYGQYNVNGEKYIIAEALSDAVAEALDWDKASIKLEKEYTGKELEYVVAQHPFLDRESLVINGDHVTTDAG...
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrol...
A7X1D8
A8FKL9
MURD_CAMJ8
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Campylobacter
MKISLFGYGKTTRAIAENLVDKFGPFDIYDDHFTETKKDTLGNLLLNPNDFDDNLSDIEIPSPGFPPKHKLIQKAKNLQSEYDFFYDIMPKSVWISGTNGKTTTTQMATHLLSHIGAVIGGNVGTPLAELDPYAKLWILETSSFTLHYTHKAKPEIYALLPISPDHLSWHGSFDNYVQDKLSVLKRMNECDVVILPKIYANTPTKAHKISYKDEKDLAVKFGIDTEKISFKSPFLLDAIMALAIEKILLDTLSYELLNSFVMEKNKLEELKDSQNRLWVNDTKATNESAVMAALNRYKDKKIHLIIGGDDKGVDLSNLFD...
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
A8FKL9
B3EGX6
RS8_CHLL2
30S ribosomal protein S8
Chlorobium
MPVTDSIADYITRIRNAGRAKNKTTDIPYSKLRENISELLVAKGYIKSFTVITTEQFPFIRIDLKYSALGEPAIREITRVSKPGRRVYQGKDIRKYLGGLGLYILSSSKGIITDKEAREQGVGGEILFRIY
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
B3EGX6
B3ESU1
FOLD_AMOA5
Methenyltetrahydrofolate cyclohydrolase
Candidatus Amoebophilus
MAVILDGKQVAHFLRQSLAEQVQTLAKEGKPIPHLAIVLVGDDPASHTYVYNKVKACQEVGFQTTFIQEASHVQESTLLYLIHKLNEDTSIHGIIIQLPLPKHINAIKIIQAITPSKDVDGLHTFNYGRMACNLPTHIPATPLGILLLLEHYQIETAGKHCVIIGRGPTVGAPLSILMSRNAYPGNATVTLCHSYTQQLTNFTRQADILVVAVGKPGLITADMIKPSTTVIDVGITRIPDTTKKRGYRLKGDVAFEEVATLCNAITPVPGGVGPMTIAALLTNTLRAATNQVYNTPTS
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
B3ESU1
A8N1T1
LIPA_COPC7
Lipoic acid synthase
Coprinopsis
MALYRAPKLQRSLLNRCLATASTTPAAASTSRTSTFRKTLEEGPTLDDFIAGDVPNNRVVLGNTSAPRLPSYLKTSIPTGASFSKIKKDLRGLNLHTVCEEARCPNIGDCWGGKPGATEAEGRSAATATIMLMGDTCTRGCRFCSVKTSRTPPPLDPHEPENTAEAISRWGLGYIVLTSVDRDDLADGGARHFAETISKIKQKAPHILVEALTGDFAGNLEHVSLVAKSGLDVYAHNIETVEALTPFVRDRRATFRQSLSVLKRAKEEGVKVTKTSIMLGVGETEDQVLDALKELRKVDVDVVTFGQYMRPTKRHMKVDR...
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
A8N1T1
O66106
RSMG_TREPA
Glucose-inhibited division protein B
Treponema
MVTPSQHALLAEGVAHLTDARTAPALCALLKQYLEELILFNTRAHLVHVTHTEELITHHLLDSLSAWPHFTNARAIADIGSGAGLPGIPLACALALYAPETELTLIERREKRIAFLENACARLALPHLRIVHADAHDLTPYTYDAITFRALCPLNHPTVYMLLNKLRPGGVILAYKGKRKLIEQETRDFLPQSCSVFPLHVPFLHEARHLVAIHTPCAAPPQ
Specifically methylates the N7 position of a guanine in 16S rRNA.
O66106
P18647
APOA1_ERYPA
Apolipoprotein A1
Erythrocebus
DEPPQTPWDRVKDLVTVYVE
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
P18647
P07189
LCP4_DROME
Larval cuticle protein IV
Sophophora
MFKILLVCALVALVAANENPEVKELVNDVQADGFVSKLVLDNGSAASATGDVHGNIDGVFEWVSPEGEHVRVSYKADENGYQPQSDLLPTPPPIPEAILKAIAYIQAHPSKE
Component of the larval cuticle.
P07189
P9WJF0
DPRE1_MYCTO
FAD-dependent decaprenylphosphoryl-beta-D-ribofuranose 2-oxidase
Mycobacterium tuberculosis complex
MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSYGDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQVTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGLTGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKLGRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKSGTYRGKVQNLTQFYHPLDMF...
DprE1 is a highly vulnerable and fully validated tuberculosis drug target.
P9WJF0
Q85CD4
PSBJ_ANTAG
Photosystem II reaction center protein J
Anthoceros
MANTTGRIPLWLIGTIAGILVIGLVGIFFYGSYSGLGSSL
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, a...
Q85CD4
A1RYD7
SYE_THEPD
Glutamyl-tRNA synthetase
Thermofilum
MEVDIRRVALKHALANAVKFGGKARVDSVVSKVFAEVPEARKAAKEVVELVKEVVEEVNSMSPESQASLLSELWPEALSGERKVEVKRLPPLPGAEEVGGKVVTRFAPNPDFVLHLGSARPAILNYYYAKKMYNGKFILRFEDTDPRTKRPMPEAYDLIREDLRWLGTPWDEEYIQSQRMEVYYEVAEALIKSGNAYVCTHSQDEIKAFRDAGKPDPCSFLPPEEHMERWEKMLSGEYPEGAAVLRIKTDPAHPNPSVRDWIAFRVLDTEKTPHPLTGDKYRVWPTYNFACAVDDHMLGVTHVLRGEEHAVNTLKQEYVY...
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
A1RYD7
Q6FF97
EFTU_ACIAD
EF-Tu 1
Acinetobacter
MAKAKFERNKPHVNVGTIGHVDHGKTTLTAAIATICAKTYGGEAKDYSQIDSAPEEKARGITINTSHVEYDSPIRHYAHVDCPGHADYVKNMITGAAQMDGAILVCAATDGPMPQTREHILLSRQVGVPYIVVFLNKCDLVDDEELLELVEMEVRELLSTYDFPGDDTPVIRGSALKALEGDAGQYGESSVLALVEALDTYIPEPERAIDKAFLMPIEDVFSISGRGTVVTGRVEAGIVKVGESVEIVGIRDTQTTTVTGVEMFRKLLDEGRAGENCGVLLRGTKREDVQRGQVLAKPGTIKPHTKFDAEVYVLSKEEGG...
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q6FF97
Q18CP5
HPDL_CLOD6
p-hydroxyphenylacetate decarboxylase large subunit
Clostridioides
MSQSKEDKIRSILEAKNIKSNFQNKENLSEFNEKKASKRAEDLLDVYYNTLSTADMEFPYWYNREYRKSDGDIPVVRRAKALKAAFSHMTPNIIPGEKIVMQKTRHYRGSFPMPWVSESFFVAQGEQMREEAKKLASNTADELTKFGSGGGNVTESFGNVVSIAGKFGMRKEEVPVLVKMAKEWVGKSVEDLGFHYEKMMPDYDLKENLMSTLICMFDSGYTLPQGREVINYFYPLNYGLDGIIEMAKECKKAVAGNASGDGLIGMDRLYFYEAVIQVIEGLQTWILNYAKHAKYLESIETDLEAKKEYSDLVEILEHIA...
Glycyl radical subunit of the HPA decarboxylase that decarboxylates phenylacetates with a hydroxyl group in the p-position. Active toward 4-hydroxyphenylacetate and 3,4-dihydroxyphenylacetate, forming 4-methylphenol and 4-methylcatechol, respectively. Is likely involved in the catabolism of aromatic amino acids such as...
Q18CP5
Q9D281
NXP20_MOUSE
Protein FAM114A1
Mus
MSDDARDTIANGVGEDAAEMPNSDSPAEDAAEVQCGPATTSNEPAPDDHMEEQPEITAMCAESTPPGILDQSKASAADETPLNGEVTEDTLVECVDSVSLEGDTGSEIPLKEQDDAAVDPSSQAGRWAGWGSWGKSLLSSASATVGHGLTAVKEKAGATLRIHSANSASPEGAPTDAENGISGNVTPDQDPARGPHTPPPPGAAGSRGMLSALTNVVQNTGKSVLTGGLDALEFIGKKTMIVLAESDPGFKRTKTLMERTVSLSQMLREAKEKEKQRLAQQLTVERTAHYGMLFDEYQGLSHLEALEILSNESESKVQSF...
May play a role in neuronal cell development.
Q9D281
Q54VG1
GPA12_DICDI
Guanine nucleotide-binding protein alpha-12 subunit
Dictyostelium
MCTRNKKDITTEYLNSKKIDRELKQESTTLQPLKLLLLGSGECGKSTIFKQIISFQDEATKKEYTPPSDYVIKNIFLNILTATSTFVRVAPSYNIEFSEEENQKIQSILNVFSDLENLDQTVFTSVSDNIKYLWNSKQIQSIYNNTNRIFQLNDSTEYLMSNIDRYSKPFKPTQNDFLRVRVKTTGIVEADFKIEAVPFKLVDVGGQKNQRRKWIHCFQDITCVLFVTSINDYDTLLEEDNSTSRFTDSLELFREMVNSNWFTKSPFVLFFNKIDLFKEKIKRIPVSQHLKDFNGNDHSYEETSQFIKNKFHTTIKNSNK...
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.
Q54VG1
Q5RC84
HEXA_PONAB
N-acetyl-beta-glucosaminidase subunit alpha
Pongo
MASSRLWFSLLLAAALAGRATALWPWPQNIQTSDQRYVLYPNNFQFQYDVSSAAQPGCSVLDEAFQRYRDLLFGSGSWPRPYLTGKRHTLEKNVLVVSVVTPGCNQLPTLESVENYTLTINDDQCLLLSETVWGALRGLETFSQLVWKSAEGTFFINKTEIEDFPRFPHRGLLLDTSRHYLPLSSILDTLDVMAYNKLNVFHWHLVDDPSFPYESFTFPELMRKGSYNPVTHIYTAQDVKEVIEYARLRGIRVLAEFDTPGHTLSWGPGIPGLLTPCYSGSEPSGTFGPVNPSLNNTYEFMSTFFLEVSSVFPDFYLHLG...
Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroiti...
Q5RC84
P0C8V8
O164_CONAH
Omega-conotoxin-like Ac6.4
Pionoconus
MKLTCVVIVAVLLLTACQLLTADDSRGTQKHRALRSDTKLSMSTRCKGKGASCSRTMYNCCTGSCNRGKCG
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav).
P0C8V8
Q3SVI5
RL21_NITWN
50S ribosomal protein L21
Nitrobacter
MFAVIKTGGRQYRVVPDDVLEIGKIAGEVGTIVQLGEVLVLGGDTPVLGAPTVAGASIAAEVLQHKRGPKVIAFKKRRRKHSKRKRGYRDEITVLRVTEILADGKSPTIGPRPKKEKAVEPVEGASDDKPRRAAKKTAAKTAEDAD
This protein binds to 23S rRNA in the presence of protein L20.
Q3SVI5
Q8JHV9
BIR7A_XENLA
XIAP homolog XLX
Xenopus
MSRWSVSQGCGNSHKALTMAGHGEQLFRGWGMVRPSMRSEAERLRSFSAWPRTCPQPSPVEMARSGFYYLGPGDRVQCFSCGGVLRSWEPGDRPDTEHRKFFPSCTFLQQQQRDPGATDSQILGQHSGEEPDRTWESVYPEMAEERDRLDSFRNWPMYAHGNPEHLAGSGFFYTGHRDNVKCFHCDGGLRNWEQGDDPWTEHAKWFPMCDFLLHVKGEAFIRRVQESLFRSPESSPDSLGSYIYDRSPASSPGSPESWRYLQSSVAQDALQMGFKQSLVASLIQSKFLLTGSSYSSVSDLVTDLLVAEEETHSTESVSVS...
Weak apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Weak inhibitor of caspase activity.
Q8JHV9
A1T705
FBID_MYCVP
Phosphoenolpyruvate guanylyltransferase
Mycolicibacterium
MNNSHADVGLVIAVKRLTAAKTRLAPMFSARTREDVVLAMLVDTITAAIAVPALRSVLVVTPDEDAADAARQLGALVLPDPTPQGHHDPLNNALTAAEVVARRENTNVVALQGDLPALRTVELAEAIGAARAHARSFVTDRHGTGTSALFSFGAPLDPHFGLDSAQRHRRSGAVELTGDWPGLRSDIDTPDDVLALNDLGVGPATARAIARAQ
Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.
A1T705
P44057
BAME_HAEIN
Outer membrane protein assembly factor BamE
Haemophilus
MQVKTLLGATFLALSLASCSTVEKVVYRIDVPQGNYLEATTVAQVKEGMTAQQVQYLLGTPVLVDPYNSQTWYYVFLQQRAYETPVQHTFTVKFDQRGIVTETHLDKPLPQVSQQGENNTIIETGEKPKSSWWKFWK
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
P44057
P93134
MT2_FRAAN
Metallothionein-like protein type 2 MET1
Fragaria
MSCCGGKCGCGAGCKCGSGCNGCGNYADITEQSSASETLVMGVVGTQKLNYGQAEAGVATEGSCSGCKCVYCTCDPCTCK
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
P93134
Q8K9Z1
RIBF_BUCAP
FAD synthase
Buchnera
MKLIRGIHNLKKINSNSAVSIGNFDGVHLGHQKLLSNLYKIGKKNNILTVLILFEPQPLEFLNNKNSPKRLTTIQNKIKYIQSWKIDIILCIKFNESFSSLSAEKFIKNILITKLNIKFIIIGDDFRFGSKRNGNISLLKEIGYQYNFKVIEISSLLYKNKIKISSTNIRKCLLENKIELARKLLGRPFSISGRVIHGNKIGRKLGYPTANISLRKNIPLNNGVYAVKISCFFNKKFVGICNIGIKPSYFSSKKHRLLEVHLFNFNLNLYEEKIEVFLYKKIRNECFFSSKNKLKEQISKDIEIVKKYFNLI
Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.
Q8K9Z1
Q08554
DSC1_HUMAN
Desmosomal glycoprotein 2/3
Homo
MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQL...
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the kerati...
Q08554
A6QC22
OTC_SULNB
Ornithine carbamoyltransferase
unclassified Sulfurovum
MRHFLTLKDFNKEELLEMIALAQKIKAQTKQKQFVPYLERQTLGMIFEKSSTRTRVSFETGIYQLGGIGLFLSANDIQLGRGEPMKDTSRVISRMVDMVMIRTFEQSKLEEFAAYSKVPVINGLTDSYHPVQLMTDYLTMIEFGKADDPICAYVGDGNNMTHSWLMLAAKLGFELRVATPKGYECDPDIVADAMEIAKESGAKITFGNDPKEAVKGCDVVTTDTWVSMGQEDEKEIRLKAFEGYMVDEAMMSLAKSDAIFLHCLPAYRGYEVSEETFEKHAEVIFTEAENRLHAQKGIMVWLDQHC
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
A6QC22
Q9YGT4
HXB6B_DANRE
Homeobox protein Hox-A7
Danio
MSSYFVNSTFPVSLPGGQESFLGQIPLYSSGYTDSLRHYPSATFGATNVQDKVYTSSYYQQAGGVFGRSGSTSACDYSTPNIYRTADRSCAIGSLEDSLVLTQDQCKTDCTEQGTERYFSTEDKPCTPVYPWMQRMNSCNGMPGSTGRRGRQTYTRFQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKWKKENKAVNSAKVSDEEDGGKAG
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Q9YGT4
Q492U9
LPLA_BLOPB
Lipoate--protein ligase
Candidatus Blochmannia
MCSLRLLLSDSYDPWFNLSLEEYIYKNIPKKQSILFLWRNQNTVVIGRAQNAWKECNTRRMERDGIKLARRNSGGGAVFHDLGNTCFTFISTQEHYDKSISSNIVLNGLSYIGIKAIISGRNDIVIRTENGEHRKISGSAYRETSGRKFHHGTLLLHVDIDKLDYYLNPDFKKLETKGITSIRSRVANLNELKPGINHQEVCLGLTEAFFQHYGMKVKPEILSTDNFCKIPEFFKQFNKQSDWNWNFGSAPAFTHQLDTRFDWGSVTLHCDIERGIIHRSHIFTDSLDPSPLEILAKKLVGIPYNNKSILCCCKEWMQSW...
Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.
Q492U9