accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
B2JF36
RSGA_PARP8
Small ribosomal subunit biogenesis GTPase RsgA
Paraburkholderia
MSGRSPKALRAATANDRAQDRVRGLVIAAHGRHYIVAPEDGSAILQCFPRGKRSEIAVGDQVLYEPTSADQGVIVEIGERRNLLYRSDQYKSKLFAANLDQLLIVLATEPHFSEDLLGRALVAAEENELKPLIVLNKIDVEAALPLARKRLQLYRGLGYTVLEVSIKGQPDAARATLEAHLNGHSTLLLGQSGMGKSTLVNLLIPDAEVATREISTALNSGRHTTTFTRLYPLPGSEGALIDSPGFQEFGLHHLTEGKLERAFPEFRPLLAECRFYNCHHLHEPGCAILEAVADGRIAKERHALYAQLVHEASQIVR
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimula...
B2JF36
P40923
YOX1_SCHPO
MBF complex negative regulatory component yox1
Schizosaccharomyces
MSLSDSPSKSGNTGKDLISNNEAKNHEDEETHQKKRRRRTTDAEATLLEQYFLKTPKPSLIERQELSKKLKSSMTPRELQIWFQNKRQSLRRSNCLSRNRLEGTGENSLLRRKSTLTLCETSTGQAELFFQSWPLHSQSVVGEMIHHEQDDYNKENKQQKVVDTTKDISRGSNGNEDSAAHQELEECARSLVELQQQCNDH
Negative regulatory component of the MBF transcription factor complex involved in cell-cycle G1/S phase-specific gene expression and more particularly DNA replication checkpoint-dependent gene expression.
P40923
A9MDR7
FLGH_BRUC2
Basal body L-ring protein
Brucella
MNKAILAVAMVLLLAGCATKPEEIGRAPDLSPVAAHLGMQNNPQFNGYPARPGKASYSLWDQRSTNFFKDPRAATPGDVLTVIISINDRANLDNKTDRERVSKGIYGGGGSFATSSITGAAAGGDMDASINTHSDSKSKGKGTIERSEDIRLQIAAIVTDTLPNGNLIIRGSQEVRVNNELRVLNVAGVVRPRDISGNNTISYDKIAEARISYGGRGRLSEIQQPPYGQQILDQFSPF
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
A9MDR7
A5V649
LIPB_RHIWR
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Rhizorhabdus
MTVDDDIEWRVTPGLSPYAETVAEMEARAAAIRAGEARELIWLLEHPPLYTAGTSAEADELLLPDRFPVFRSGRGGRYTYHGPGQRVGYVLLDLDRRGRDVRCFVAAIENWVIATLGDFGIAGRSEPGRVGIWTGHGPDEAKIGAIGVRVRRWVSFHGFSLNVDPDLSHFSGIVPCGLGEFAVTSMARLGIPAEMAAVDAALRRHFPAMLAGLRCSTRSDKDS
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
A5V649
A2C0W8
SYP_PROM1
Prolyl-tRNA synthetase
Prochlorococcus
MRVSRLMLNTLRDVPSEADIISHQLLVRGGYIKRITGGIYAYMPLLWKVLKKITSIVEEELSTKGCLQTLLPQLQPSEIWERSGRWKSYTQGEGIMFSLKDRQGKELGLGPTHEEVITQIISQTIHSYKQLPINIFQIQTKFRDEIRPRFGLMRSREFIMKDAYSFHANENDLQSTYSDMRNAYQNIFTKCGLDFVCVDADSGAIGGAASQEFMVTAESGEDLILISSDGKYGANQEKAVSIIEEGNLLEPNKPSIIKTPNQKTIDELCNYNDFHPSQIVKVLAYLATCDDNKKYPVLVSIRGDQEINDIKLSNKISQEL...
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two addit...
A2C0W8
A5IBI8
NADD_LEGPC
Nicotinate mononucleotide adenylyltransferase
Legionella
MHSIAIFGGTFDPVHNGHIKTSLAIQANFGFDSYYFLPCKSPAIKPPSFASSEQRVEMLKLALKPYPDFKIDTRELDRDTPSYMVYTLQSFRQEYTDSSLTLIIGYDGLLTLPQWYQWEKIISLANLLVINREEFFQQPVPKSVQTLLNQYRNDDKNILLNHHAGSICLYNAGHYDISSTKIREQLKQHKDVKNNLPDLVYDYIKKQGLYQ
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
A5IBI8
A7MX36
BIOB_VIBC1
Biotin synthase
Vibrio
MEVRHNWTHAEVRDLMEKPFMDLLFEAQLVHRQYQQTNYVQVSTLLSIKTGACPEDCKYCPQSARYTTDIEKERLMEVERVLDAAQKAKNAGSTRFCMGAAWKNPKERDMPHLTDMIKGVKGMGLETCMTLGMLTPDQAKQLATAGLDYYNHNLDTSPEFYGNIITTRTYQDRLDTLSHVRDAGMKICSGGIIGMGESANDRAGLLVELANLPVHPESVPINMLVKVKGTPLEEVDDVEPFDFIRLIAIARIMMPQSAVRLSAGRENMNEQMQALCFMAGANSVFYGCKLLTTPNPSEDKDMMLFNKLGINSQEVSQKPD...
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
A7MX36
P22838
DPO3B_PROMI
DNA polymerase III subunit beta
Proteus
MKFIIEREQLLKPLQQVSGPLGGRPTLPILGNLLLKVTENTLSLTGTDLEMEMMARVSLSQSHEIGATTVPARKFFDIWRGLPEGAEISVELDGDRLLVRSGRSRFSLSTLPASDFPNLDDWQSEVEFTLPQATLKRLIESTQFSMAHQDVRYYLNGMLFETENTELRTVATDGHRLAVCAMDIGQSLPGHSVIVPRKGVIELMRLLDGSGESLLQLQIGSNNLRAHVGDFIFTSKLVDGRFPDYRRVLPKNPTKTVIAGCDILKQAFSRAAILSNEKFRGVRINLTNGQLKITANNPEQEEAEEIVDVQYQGEEMEIGF...
Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalyti...
P22838
Q1XDL4
YCF42_NEOYE
Thioredoxin peroxidase
Neopyropia
MISGPNCLRVGQLAPDFSATAVYDQEFKTLKLSDLKNKYIVLFFYPLDFTFVCPTEITAFSDKYNAFSELNTEVLGVSVDSEYSHLAWLQTDRESGGLGDLSYPLVSDLKKEISAAYNVLNSDGVALRGLFIIDPKGIIQYSTINNLEFGRSVEETLRVLQAIQYVQSHPDEVCPANWKPGDKTMNPDPIKSKNYFAAA
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Q1XDL4
P63344
FTSH_SALTI
ATP-dependent zinc metalloprotease FtsH
Salmonella
MAKNLILWLVIAVVLMSVFQSFGPSESNGRKVDYSTFLQEVNQDQVREARINGREINVTKKDSNRYTTYIPINDPKLLDNLLTKNVKVVGEPPEEPSLLASIFISWFPMLLLIGVWIFFMRQMQGGGGKGAMSFGKSKARMLTEDQIKTTFADVAGCDEAKEEVAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGLGGGHDEREQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVG...
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
P63344
A6LDS8
MIAA2_PARD8
Isopentenyl-diphosphate:tRNA isopentenyltransferase 2
Parabacteroides
MNSLVILLGPTGVGKTELSLQVAERFGSPIISSDSRQLYKDLPIGTAAPTPEQMARVKHYMVGTLSLTDYYSASNFEEDVVSLLSELHKTIPTVVMTGGSMMYIDAVCKGIDDIPTVTPEIRDALYMQFETEGLAPILAELKEADPVHYEEVDRNNYKRVIHAVEICRMTGKPYSSFRTNIKKERPFRIIKVGLNRDRDELCDRINQRVDQMMSEGLLEEARRAYPFRHLNSLNTVGYKELFNYFSGEWTLDLAVEKIKRNSRVYARKQMTWFKRDPEITWFHPDETEAIFTHLSQQII
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
A6LDS8
Q6G928
AROK_STAAS
Shikimate kinase
Staphylococcus
MNHDKSPIILIGFMGTGKSTIGKYVADEQNLSFIDIDSYIEEKYKLTIPEIFSKHGEQYFRNLEFTCLQECINTADIIATGGGIIESEEAFNFLKNQKNIIWLDCNIDIIYSRINDDPHRPNANNKTIKQLNDLYCSRNLRYNEIAFKKFDSHLLSISEIYYELLNLIKASDQY
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Q6G928
P43129
FRE_PHOLU
NAD(P)H:flavin oxidoreductase
Photorhabdus
MTTLSCKVTSVEAITDTVYRVRLLPDSPFLFRAGQYLMVVMDERDKRPFSMASTPSEKEFIELHIGASELNLYAMAVMDRILDQKVINIDIPHGKAWFRKSSANPLLLIAGGTGFSYTRSILLTALEEQPKRHISMYWGGRESQHLYDLAELRLLTERYPNLKVIPVVEQSDNGWCGRTGTVLKAVLEDFGSLANYDIYIAGRFEMAKIARERFCSERDASADSMYGDAFEFI
Involved in bioluminescence. It is a good supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction. Preferably uses riboflavin as an electron acceptor when NADPH is used as an electron donor.
P43129
B0RZU7
RL16_FINM2
50S ribosomal protein L16
Finegoldia
MLMPKRVKYRRVHRGRMKGKALKGNTLTYGDYGIQALGSCWLTANQIEAARRAMTRYIKRGGNIWIKVFPDKPVSKKPIGIRMGSGKGAPEYWVAVIKPGRVLFEMAGVPEDVAREAMRLAQHKLPIKTKFIAREEFGEKDGEADEN
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
B0RZU7
A6V8R6
RND_PSEA7
Ribonuclease D
Pseudomonas
MFVTAPEIQWIRDDASLAQQCREWRTQPYLALDTEFMRVDTFYPAAGLVQVGDGRREWLIDPLLVRDWGPFAELLEDPRVVKVLHACSEDLEVFLRLTGSLPVPLFDTQLAAAYLGMAHSMGYSKLVKEVLDIDLPKDETRSDWLQRPLTEMQMRYAADDVQHLAQVYLALDARLSEEKRAWLLEDGAELVANLCRESDPREAYREVKLGWRLRPQQLAVLRELCAWREEQARLRNRPRNHVLRERTLWPLARLLPKNKTDLAAIEDMHPRTVRQDGDFLIELIAEAARLPQSEWPEALPEPLPPEVTPLLKSLRAIGQR...
Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides.
A6V8R6
Q8D234
RL7_WIGBR
50S ribosomal protein L7/L12
Wigglesworthia
MSINKQQILDAVSEMSVLEISELVSMMEKKFGVSSINNNNINVNKVDESVEEKSEFDVLLLEIGKNKISVIKSVRSALSLGLKESKDLIESELPITLKTGLNKKDAESLKKEIETSGARIELK
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
Q8D234
A0A0P0X004
HMA9_ORYSJ
Protein HEAVY METAL ATPASE 5
Oryza sativa
MAHLQLSAVAGGGRPAAAGGGGDEMEDVRLLDSYDEEMGGGAAAAAAGEEEEAHVRVTGMTCSACTSAVEGAVSARRGVRRVAVSLLQNRAHVVFDPALLKVEDIIEAIEDAGFDAEIIPDTAISQPKAQKTLSAQFRIGGMTCANCVNSVEGILKRLSGVKGAVVALATSLGEVEYDPSVINKDEIVEAIEDAGFEAAFLQSSEQDKILLGLTGLHTERDVNVLHDILKKMIGLRQFDVNATVSEVEIIFDPEAVGLRSIVDAIETGSNGRLKAHVQNPYARGASNDAHEAAKMLHLLRSSLFLSIPVFFIRMVCPHIP...
Metal efflux transporter that may play a role in detoxification of heavy metals, such as zinc, copper, lead and cadmium, especially in the shoots.
A0A0P0X004
Q9JXF1
BICOA_NEIMB
Pantothenic acid kinase
Neisseria
MTVLKLSHWRVLAELADGLPQHVSQLARMADMKPQQLNGFWQQMPAHIRGLLRQHDGYWRLVRPLAVFDAEGLRELGERSGFQTALKHECASSNDEILELARIAPDKAHKTICVTHLQSKGRGRQGRKWSHRLGECLMFSFGWVFDRPQYELGSLSPVAAVACRRALSRLGLDVQIKWPNDLVVGRDKLGGILIETVRTGGKTVAVVGIGINFVLPKEVENAASVQSLFQTASRRGNADAAVLLETLLVELDAVLLQYARDGFAPFVAEYQAANRDHGKAVLLLRDGETVFEGTVKGVDGQGVLHLETAEGKQTVVSGEI...
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Q9JXF1
B8E690
DAPF_SHEB2
PLP-independent amino acid racemase
Shewanella
MIQFTKMHGLGNDFMVVDGVTQNVFFSPEQIRRLADRNFGIGFDQLLLVEPPYDPDLDFHYRIFNADGTEVEQCGNGARCFARFVRNKGLTNKSKIRVSTSSGKMTLRLERDGTVTVNMGVPILEPSQIPFKAKKPEKTYLLQTPMQTFLCGAASMGNPHCVLDVEDVASASVAEIGAMLTKHERFPRGVNVGFMQVVDSGHIKLRVYERGAAETLACGTGACAAVVVGQVQGKLGQQVRVDLPGGTLTINWEGEGKPLWMTGPAQHVYDGQIQL
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
B8E690
P57979
UVRA_PASMU
Excinuclease ABC subunit A
Pasteurella
MDKIEVRGARTHNLKNINLTIPRDKLIVITGLSGSGKSSLAFDTLYAEGQRRYVESLSAYARQFLSLMEKPDVDHIEGLSPAISIEQKSTSHNPRSTVGTVTEIHDYLRLLFARVGEPRCPNHDVPLAAQTISQMVDKVLSLPEESKMMLLAPVVKERKGEHVKLLEQIAAQGYIRARIDGEICDLSDAPKLELHKKHTIEVVVDRFKVRSDLATRLAESFETALELSGGTAVVASMDEPETEELVFSANFACPHCGYSVPELEPRLFSFNNPAGACPTCDGLGVQQYFDEKRVVQNPSISLASGAVKGWDRRNFYYYQM...
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
P57979
B2JHD4
RPPH_PARP8
(Di)nucleoside polyphosphate hydrolase
Paraburkholderia
MLDREGFRPNVGIILLNAHNEVFWGKRLREHSWQFPQGGIKYGETPVQAMYRELHEETGLLPEHVKVIGRTRDWLRYEVPDKFIKREVRGHYRGQKQIWFLLRMVGRDCDICLRATDHPEFDAWRWNEYWVPLDCVIEFKRDVYQLALTELSRFLRRPQPRTERPGGHHHGQRYPRMASSVNAPPGASMASSMTVTTVTTAIAVESTLRATIESDCSSTEDPAVQAPGLRD
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
B2JHD4
Q31MN3
KATG_SYNE7
Peroxidase/catalase
Synechococcus
MTATQGKCPVMHGGATTVNISTAEWWPKALNLDILSQHDRKTNPMGPDFNYQEEVKKLDVAALKQDLQALMTDSQDWWPADWGHYGGLMIRLTWHAAGTYRIADGRGGAGTGNQRFAPLNSWPDNTNLDKARRLLWPIKQKYGNKLSWADLIAYAGTIAYESMGLKTFGFAFGREDIWHPEKDIYWGPEKEWVPPSTNPNSRYTGDRELENPLAAVTMGLIYVNPEGVDGNPDPLKTAHDVRVTFARMAMNDEETVALTAGGHTVGKCHGNGNAALLGPEPEGADVEDQGLGWINKTQSGIGRNAVTSGLEGAWTPHPTQ...
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Q31MN3
Q58DR6
EMP3_BOVIN
Epithelial membrane protein 3
Bos
MSLLLLVVSALHILILILLFVATLDKSWWTLPGKESLNLWYDCTWNSDNKTWACSNVSENGWLKAVQVLMVLSLILCCLSFILFMFQLYTMRRGGLFYATGFCQLCTSVAVFTGALIYAIHAEEILADRPSGGSFGYCFALAWVAFPLALASGIIYIHLRKRE
Probably involved in cell proliferation and cell-cell interactions.
Q58DR6
Q9P291
ARMX1_HUMAN
ARM protein lost in epithelial cancers on chromosome X 1
Homo
MGRTREAGCVAAGVVIGAGACYCVYRLAWGRDENEKIWDEDEESTDTSEIGVETVKGAKTNAGAGSGAKLQGDSEVKPEVSLGLEDCPGVKEKAHSGSHSGGGLEAKAKALFNTLKEQASAKAGKGARVGTISGNRTLAPSLPCPGGRGGGCHPTRSGSRAGGRASGKSKGKARSKSTRAPATTWPVRRGKFNFPYKIDDILSAPDLQKVLNILERTNDPFIQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTKDPIIREKTYNALNNLSVNAENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNH...
Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerv...
Q9P291
Q1QXW0
RMF_CHRSD
Ribosome modulation factor
Chromohalobacter
MKRQKRDRFQRAYVHGYKAGMTGRSRDDCPSQDINLREYWMSGWREGRGDQWAGMTGISGIHKNPMVLS
During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes).
Q1QXW0
Q870I4
MTL32_CANGA
MTL3alpha2 protein
Nakaseomyces/Candida clade
MSKKSRISITHLLNPIQEENLKEKLQEINNQLISLCSSLPKRQSLPGPSSDILRFLSRNNLDPQEIGLIKTTYRLSTLLSKLREHEIVFNVVTKDHLLKKGVPNHYAASYRGHRFTRENVQILETWYRNHIDNPYLDHNSQQYLAQKTNLSKIQIKNWVANRRRKQKSIYISLFDIHNIESGEYAYIEKVCYIIIIICHLFLVFSLSCLT
Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.
Q870I4
Q474Y3
PANC_CUPPJ
Pantoate-activating enzyme
Cupriavidus
MKVISSIQELRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQSEGVYVLFAPTERDMYPEPQEYRVDPPHDLGDILEGEFRPGFFKGVCTVVMKLFTAAQPRVAVFGKKDYQQLMIVRRMVHQFALPIEIVPAETVRAEDGLALSSRNRYLTEAERAEAPMLYRTLHDVRDTVLGSDRAATRLATVEADACATLAQRGWKPDYVSIRKRSNLQAPTPEEFAAGEPLVVLTAAKLGATRLIDNLEI
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q474Y3
Q5JDG6
CUTA_THEKO
Divalent-cation tolerance protein CutA
Thermococcus
MEAIIVYTTFPDWESARKVTRELLERKLIVCANLREHEAMYWWEGKIEEGKEVGAIYKTEVSKWKELRETIKELHPYDVPMIARIDLDKLNREYSEWMARVLFG
Involved in resistance toward heavy metals.
Q5JDG6
P0DMY4
BDSA_ANEVI
Blood depressing substance 10
Anemonia
MNKALFLCLVVLCAAVVFAAEDLQKAKHAPFKRGAQVCFCPGKVDRGDLWILRGDCPGGYGYTSNCYTWPNICCYPQSFSGR
Blocks Kv3 voltage-gated potassium channels. Reduces blood pressure.
P0DMY4
A9BWI1
KAD_DELAS
Adenylate monophosphate kinase
Delftia
MKLILLGAPGAGKGTQAAFICQKYGIPQISTGDMLRAAVKAGTPLGQQAKAVMDAGQLVSDDLIINLVKERIAQADCANGFLFDGFPRTIPQADAMKAAGVKLDYVLEIDVPFDAIIERMSGRRSHPASGRTYHVKFNPPKVEGQDDVTGEPLVQREDDKEETVKKRLDVYSSQTRPLVDYYRAWAEKEAAAAPKYRAISGLGSVEDITQRALAALAE
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
A9BWI1
B7N145
BIOH_ECO81
Carboxylesterase BioH
Escherichia
MNNIWWHTKGQGNVHLVLLHGWGLNAGVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEVVLRQAPDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVPMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPDEFCHLLVALKQRV
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.
B7N145
E1WAC4
SICP_SALTS
Chaperone protein SicP
Salmonella
MGLPLTFDDNNQCLLLLDSDIFTSIEAKDDIWLLNGMIIPLSPVCGDSIWRQIMVINGELAANNEGTLAYIDAAETLLLIHAITDLTNTYHIISQLESFVNQQEALKNILQEYAKV
Molecular chaperone required for SptP stabilization and secretion.
E1WAC4
Q8TV03
RL7A_METKA
Ribosomal protein L8e
Methanopyrus
MSKPMYVKFEVPEELAEKAYEALEIARDTGRIRKGTNETTKAVEREEAVLVLIAEDVDPEEVVAHLPELCDEKGIPYVYVPSKDELGAAAGIDVAAASACIIDPGDAKDLVDEIIEKVEELRE
Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.
Q8TV03
Q6K7E6
ERF1_ORYSJ
Ethylene-responsive element-binding factor 1
Oryza sativa
MCGGAIIHHLKGHPEGSRRATEGLLWPEKKKPRWGGGGRRHFGGFVEEDDEDFEADFEEFEVDSGDSDLELGEEDDDDVVEIKPAAFKRALSRDNLSTITTAGFDGPAAKSAKRKRKNQFRGIRQRPWGKWAAEIRDPRKGVRVWLGTFNSAEEAARAYDAEARRIRGKKAKVNFPEAPTTAQKRRAGSTTAKAPKSSVEQKPTVKPAFNNLANANAFVYPSANFTSNKPFVQPDNMPFVPAMNSAAPIEDPIINSDQGSNSFGCSDFGWENDTKTPDITSIAPISTIAEVDESAFIKSSTNPMVPPVMENSAVDLPDLE...
Probable transcriptional activator that may be involved in defense signaling pathway. Binds in vitro to the DNA sequence 5'-AGCCGCC-3' of the GCC-box element found in pathogenesis-related (PR) gene promoters. The transcriptional activation is enhanced in vitro by the presence of MPK12/BWMK1.
Q6K7E6
Q2VB19
PUM1_CHICK
Pumilio homolog 1
Gallus
MSVACVLKRKAVLWQDSFSPHLKQHAQDTANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWESDDSSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQGFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDAENDENDKGDKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDTDVKDFSRTPGNCQNSASEVDLLGPNQNGSE...
Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts ...
Q2VB19
P62942
FKB1A_HUMAN
Rotamase
Homo
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate th...
P62942
Q04208
LPT_SERMA
thr operon attenuator
Serratia
MRNISLTTTIITTTDTTGNGAG
This protein is involved in control of the biosynthesis of threonine.
Q04208
A0A1U8QYW8
ALNF_EMENI
Asperlin biosynthesis cluster protein F
Aspergillus subgen. Nidulantes
MADYVIQNLTSNLQAMQYAYSSREEMPVWATKLLTPIFMAVAVLTTLPPPGPLRVIVGLTAFTSLWLHVLTHWVSGPAFFMDAIFMISITVRWLLMFVAGTPEIDYHQTTQSGTTITHKGTKDSSTLRQGLTKLRWSVELWSCWRGQGWNFVDQHLPRGAERTQSRWEFLVSNAGRVLLNQYISDLVRKYAFCALWPAQVDAHVDFSSLPLLNRHGLVALQLIRDSLMLDSEYRKASILFVGLHLSTPDRWPSLFGNMRDLYTVRNFWGRVWHQIFRQIFTRCGDIVANALNAQKGTLLYKYSRLYVGFLVSGVQHYACA...
Acetyltransferase; part of the gene cluster that mediates the biosynthesis of asperlin, a polyketide showing anti-inflammatory, antitumor and antibiotic activities . The first step of the asperlin biosynthesis is the production of the intermediate 2,4,6-octatrienoic acid by the highly redusing polyketide synthase alnA ...
A0A1U8QYW8
Q03QY7
ATPG_LEVBA
F-ATPase gamma subunit
Levilactobacillus
MAESIHDVQRRINSTKATRQITSAMHMVSTAKLNKIQKQAVGYQDYVSKVKAVVMHLSQSHLLDNSSSSLQSNRPVKKTAYLVITSDRGMVGSYNSSVLRDTNAFIKERTPNPDDYMVLAVGGTGADFYKHRGVNVAYEYRGVSDVPEFNEVREIVKTVTTMFNNEVFDELFVCYNHFVNRISSRFRAEKMLPVDKETMSTDAAKDTQAAPLTAEYDTEPSEEEVLQVVLPQYAESLVYGAILDAKTAEHASSTNAMQSATDNADDLIATLQLHYNRARQAAITTEITEITGGQEALNN
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
Q03QY7
Q8LBM2
TIF5A_ARATH
Jasmonate ZIM domain-containing protein 8
Arabidopsis
MKLQQNCDLELRLFPTSYDSDSSDTTSVVESTSSGNPQPNEESQRITIFYNGKMCFSSDVTHLQARSIISIASREMKTKSSSNGSDPPNKSTSFHHNQLPNPKASMKKSLQSFLQKRKIRIQATSPYHSRR
Repressor of jasmonate responses. Unable to associate strongly with COI1 in the presence of jasmonoyl-isoleucine (JA-Ile) and is therefore more resistant to JA-mediated-degradation than other TIFY/JAZ proteins. Repress gene expression through direct recruitment of the corepressor TOPLESS to cognate transcription factor...
Q8LBM2
Q2YYM5
ECFA2_STAAB
Energy-coupling factor transporter ATP-binding protein EcfA2
Staphylococcus
MTIRFDNVSYTYQKGTPYQHQAIHDVNTEFEQGKYYAIVGQTGSGKSTLIQNINALLKPTTGTVTVDDITITHKTKDKYIRPVRKRIGMVFQFPESQLFEDTVEREMIFGPKNFKMNLDEAKNYAHRLLMDLGFSRDVMSQSPFQMSGGQMRKIAIVSILAMNPDIIVVDEPTAGLDPQSKRQVMRLLKSLQTDENKAIILISHDMNEVARYADEVIVMKEGSIVSQTSPKELFKDKEKLADWHIALPEIVQLQYDFEQKHQTKLKDIALTEEAFVSLYKEWQHEK
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Q2YYM5
Q9I596
NCASE_PSEAE
N-acylsphingosine amidohydrolase
Pseudomonas
MSRSAFTALLLSCVLLALSMPARADDLPYRFGLGKADITGEAAEVGMMGYSSLEQKTAGIHMRQWARAFVIEEAASGRRLVYVNTDLGMIFQAVHLKVLARLKAKYPGVYDENNVMLAATHTHSGPGGFSHYAMYNLSVLGFQEKTFNAIVDGIVRSIERAQARLQPGRLFYGSGELRNANRNRSLLSHLKNPDIVGYEDGIDPQMSVLSFVDANGELAGAISWFPVHSTSMTNANHLISPDNKGYASYHWEHDVSRKSGFVAAFAQTNAGNLSPNLNLKPGSGPFDNEFDNTREIGLRQFAKAYEIAGQAQEEVLGELD...
Catalyzes the cleavage of the N-acyl linkage of the ceramides (Cers) to yield sphingosine (Sph) and free fatty acid at an optimal pH of 8-9. Also catalyzes the synthesis of Cers from Sph and fatty acid.
Q9I596
P57666
ORN_STRCO
Oligoribonuclease
Streptomyces albidoflavus group
MNDRMVWIDCEMTGLSLSDDALIEVAALVTDSELNILGEGVDIVIRPPERALETMPEVVREMHTASGLLAELDGGTTLADAEAQVLAYVREHVKEPGKAPLCGNSVGTDRGFLLRDMATLEGYLHYRIVDVSSIKELARRWYPRAYFNSPEKNGNHRALADIRESIAELRYYREAVFVPQPGPDSDTARAIAAKHVVSAG
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
P57666
Q9PQK9
DBH_UREPA
DNA-binding protein HU
Ureaplasma
MNAKIKAKTRSQMIDELSKMLNIEKKQTKAFMDTYEAFLILELSRAKEVRLGNIGKFKVSVRAERKGINPKTGETVIIPEKTIPKFTFTKGIKEIINAGISIDNERVSIDDNDFDDDDEFVEEYIVSENN
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
Q9PQK9
B7V3X6
METXS_PSEA8
Homoserine transsuccinylase
Pseudomonas
MPTVFPDDSVGLVSPQTLHFNEPLELTSGKSLAEYDLVIETYGELNATQSNAVLICHALSGHHHAAGYHSVDERKPGWWDSCIGPGKPIDTRKFFVVALNNLGGCNGSSGPASINPATGKVYGADFPMVTVEDWVHSQARLADRLGIRQWAAVVGGSLGGMQALQWTISYPERVRHCLCIASAPKLSAQNIAFNEVARQATLSDPEFLGGYFQEQGVIPKRGLKLARMVGHITYLSDDAMGAKFGRVLKTEKLNYDLHSVEFQVESYLRYQGEEFSTRFDANTYLLMTKALDYFDPAAAHGDDLVRTLEGVEADFCLMSF...
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
B7V3X6
A1BDZ0
QUEF_CHLPD
PreQ(0) reductase
Chlorobium
MKKEILEVFDNTFPGRDYTIEIVNPEFTSVCPITALPDFGTIIIRYIPDKSCVELKSLKYYFLEFRNAGIFYENITNTILDDLTSVLQPREMTVITQWKARGGITETVSVTWPQKQ
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
A1BDZ0
P50383
TRPB1_SACS2
Tryptophan synthase beta chain 1
Saccharolobus
MVKEDEILPKYWYNIIPDLPKPLPPPRDPQGAYFSRIDLLRSILPKEVLRQQFTIERYIKIPEEVRDRYLSIGRPTPLFRAKRLEEYLKTPARIYFKYEGATPTGSHKINTAIPQAYFAKEEGIEHVVTETGAGQWGTAVALAASMYNMKSTIFMVKVSYEQKPMRRSIMQLYGANVYASPTNLTEYGRKILETNPQHPGSLGIAMSEAIEYALKNEFRYLVGSVLDVVLLHQSVIGQETITQLDLLGEDADILIGCVGGGSNFGGFTYPFIGNKKGKRYIAVSSAEIPKFSKGEYKYDFPDSAGLLPLVKMITLGKDYV...
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
P50383
A9B689
ARAA_HERA2
L-arabinose isomerase
Herpetosiphon
MLDLKQYEVWFITGSQHLYGPETLEQVAKHSQIIAAGLDQSSTIPVRVVFKPVLKTPDEIYNLVLEANAAKNCIGLVAWMHTFSPAKMWIAGLRSLQKPLAHLHTQFNSEIPWSEIDMDFMNLNQAAHGDREFGFIVSRMRLERKVIVGHWQDSEVHDRIAAWTRAAAAWHDAQGARFARFGDNMREVAVTEGDKVNAQMRLGYSVSGYGVGDLVRFVNEVSDADIDSTLQEYAEQYELAAGLQAGGEQHHSLREAARIELGLRYFLEHGNFKGFTTTFEDLHGLVQLPGLGPQRLMDRGYGFAGEGDWKTAALVRAMKV...
Catalyzes the conversion of L-arabinose to L-ribulose.
A9B689
B6JFC5
COAD_AFIC5
Pantetheine-phosphate adenylyltransferase
Afipia
MAHVALYPGSFDPVTNGHVDVVRQACTLVDRLIVAIGVHPGKAPLFSVDERRAMIVEVFSPLAATTGCAIECVTFDNLTVAAAEKSGATILIRGLRDGTDLDYEMQIAGMNQTLVPSVQTIFIPASPTVRPITATLVRQIASMGGDVSAFVPKAVAARLKAKFSQ
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
B6JFC5
B1YKA0
FPG_EXIS2
DNA-(apurinic or apyrimidinic site) lyase MutM
Exiguobacterium
MPELPEVETVRRSLERTVSGKTISSVKVFHPKMIRGMEVAPFVDALKQERIERVERRGKFLLFTFDRFYLVSHLRMEGKYFPYPQAIEKDKHTHVIFRFTDGSELHYNDVRKFGTMELREKETAMSVPPLAQLEREPFDPTFTAEVLAENLIRKKRSPIKTSLLDQSIFLGLGNIYVDETLFAARVHPLTKAGALTLDDISRIHAAGVDVLAKAVESGGSTIRSYVSPTGKGEFQLQLAVYGQTGAPCPRCGTAIEKIKVGGRGTHFCPTCQQVAL
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. ...
B1YKA0
A0A1B4XBH9
SDNS_SORAA
Sordarin/hypoxysordarin biosynthesis cluster protein S
Sordaria
MTEQAQREAELKRRKVRKGTHSCWECRRRKIRCQFGAGNDTVCLPCQARGSTCRSQEYVDKDARPSQQPDRRMAQRLGRLEELMARLVDRILPEAGGQLANRSTTQSNRGSRSPSPDSAQNEGLAFHQTLDVLEASLGPNTPAGLLLGLRDAAQPASMLTPESDHSPAPSKLTPSRNSKTSRSLYALFPPQEALPVLMKANAGPYYLTSLFSSFRDLIEGKVETANSVTVIPPAVSHPTVLARRLLQICICMQQLNPGYDTSPLQIKGTIPEYMNNVVTTVTNLVTSIDEIVSTGEGLESLVLLGLWHANAGNLRKAWLT...
Transcription factor; part of the gene cluster that mediates the biosynthesis of sordarin and hypoxysordarin, glycoside antibiotics with a unique tetracyclic diterpene aglycone structure . First, the geranylgeranyl diphosphate synthase sdnC constructs GGDP from farnesyl diphosphate and isopentenyl diphosphate . The dit...
A0A1B4XBH9
C3P4F6
QUEC_BACAA
Queuosine biosynthesis protein QueC
Bacillus cereus group
MKKEKAVVVFSGGQDSTTCLFWAIEQFAEVEAVTFNYNQRHKLEIDCAVEIAKELGIKHTVLDMSLLNQLAPNALTRTDMEITHEEGELPSTFVDGRNLLFLSFAAVLAKQVGARHIVTGVCETDFSGYPDCRDVFVKSLNVTLNLSMDYPFVIHTPLMWIDKAETWKLSDELGAFEFVREKTLTCYNGIIGDGCGECPACQLRKAGLDTYLQEREGASN
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
C3P4F6
A5IFJ6
ATP6_LEGPC
F-ATPase subunit 6
Legionella
MGEEGFLAHFAFSIGGLPITQSVLTTWFIMISLFIMAWSTTYKCSLLQPSTYQLLWEGVLSTMYDAIKEVLPDHVELIFPFVATLWIFILVSNLIGVIPGFYSPTADLSVTASLAMMTFLSVHWFGIRAEGWREYLKHYIKPTPFLLPFHLISEISRTLALAVRLFGNIMSLQLTALIVLMIAGFLVPIPILILHIIEAIIQAYIFGMLALIYIAGGIQAHELKSQGESL
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
A5IFJ6
A2BQ25
CHLB_PROMS
Light-independent protochlorophyllide reductase subunit B
Prochlorococcus
MELTLWTYEGPPHVGAMRIASSMKDIHYVLHAPQGDTYADLLFTMIERRGQRPPVTYTTFQARDLGGDTAELVKKNIKEAVERFKPKTLLVGESCTAELIQDQPGALAKGMGFDMPIVNLELPAYSKKENWGASETFYQLTRTLLKEKVSSSEKISPLRWKELGRRPKVNILGPSLLGFRCRDDVIEIQRILSEQGIDTNVVAPLGASPDDIERLIDAEINICLYPEIAEASCEWLKRNFGMEYTNTIPIGIKNTIEFINEVHKKLDLPLTNKEELENKSKLPWYSKSVDSNYLTGKRVFIFGDGTHAIAAAKIAKEELG...
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
A2BQ25
Q44840
PTGA_BORBU
Glucose-specific phosphotransferase enzyme IIA component
Borreliella
MGFLDFFKKTATLDLIAPISGKVMSIDKVPDEAFAEKIVGDGIAILPTSNELLAPCDGKIGKIFKTNHAFSLETKEGVEIFVHFGINTLNLNGKGFTRVAEEGINVKQGEVIIRLDLEYLKEHSESVITPVVIANSDEVSSIEYSFGRLENDSEYILSSSTVLTEEIRHKISQTKPVIAGKDLVLRVKK
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose t...
Q44840
Q1GCH8
UBIG_RUEST
3-demethylubiquinone 3-O-methyltransferase
unclassified Ruegeria
MQAQQSTVDPSEIAKFEAMAAEWWDPNGKFKPLHMLNPCRLDYITSQIAGEFDRDLKTDAPFAGLRILDIGCGGGLLSEPMARLGAEVVGADAAEGNLPVARIHAEQSGLEIDYRHTTAEAMAEAGEQFDVVLNMEVVEHVADPLSYLTATQQLLKSGGLQICSTINRNPKSYAMAIFGAEVVMRWLPRGTHEWSKFITPDELFALLEQAGLNPVDRKGFVFNPILWKWSISDRDLSVNYVTASTKS
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Q1GCH8
Q6QJE2
SULP2_CHLRE
Sulfate permease 2, chloroplastic
Chlamydomonas
MASTTLLQPALGLPSRVGPRSPLSLPKIPRVCTHTSAPSTSKYCDSSSVIESTLGRQTSVAGRPWLAPRPAPQQSRGDLLVSKSGAAGGMGAHGGGLGEPVDNWIKKLLVGVAAAYIGLVVLVPFLNVFVQAFAKGIIPFLEHCADPDFLHALKMTLMLAFVTVPLNTVFGTVAAINLTRNEFPGKVFLMSLLDLPFSISPVVTGLMLTLLYGRTGWFAALLRETGINVVFAFTGMALATMFVTLPFVVRELIPILENMDLSQEEAARTLGANDWQVFWNVTLPNIRWGLLYGVILCNARAMGEFGAVSVISGNIIGRTQ...
Part of the ABC-type chloroplast envelope-localized sulfate transporter.
Q6QJE2
B0B7P6
EX7L_CHLT2
Exodeoxyribonuclease VII large subunit
Chlamydia
MSITSPPIEVSVLTDSIKNLLEKNFLRVVVKGELSNVSLQTSGHLYFAIKDSKAVLNGAFFHFRSKYFDRKPKDGDYVILHGKLTVYAPRGQYQIVAYALTFSGEGNLLQQFEERKQRLAAEGYFDPKRKKPLPSGARVIGVITSPTGAVIQDILRVLSRRCHQFQVILYPVTVQGATAAQEISQAIQFFNQNSMRVHALIIARGGGSIEDLWAFNEEELVKSIVASSIPIISAVGHETDFTLCDFASDVRAPTPSAAAEIVCKSSDQYRQELQNLRRYVSSHARQFIAAKKNLLTHWQRHLASVDFYHTAQQTLDYTRA...
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
B0B7P6
Q8KC17
TRPD_CHLTE
Anthranilate phosphoribosyltransferase
Chlorobaculum
MRQQEILQKLLEGHDLSRQEMETCMNSIMENRFTDAGTGAILALLQKKGATPAEVIGACASIVSKSTPVTLDQQAVDTCGTGGDHTGTFNISTAAAFIACGAGIPIAKHGNRSITSKCGSADVLEALGYQVDLPPCATEELFRETGFAFLFAPLYHPSMKAVAAIRKELGIKTIFNMLGPIINPAGVRRQLIGVFDPSVMDIYAEVLLLNGCEHAMLVHGSTGNSMGLDEPSVCGPTSMIELHQGQIIRHTVEPEDFGLGRWDIGELAGGDSHVNAQIIREILDGSAPQAKIDAALFASAITCYVSGKASCIDEGMSLSK...
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q8KC17
B0S6J3
SRGP2_DANRE
SLIT-ROBO Rho GTPase-activating protein 2
Danio
MTSPAKFRKDKEIIAEYETQVKEIRAQLVEQLKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRYTKDPQFKKEQNILSPVNCWNLLLAQVKRESRDHATLSDLYLNNIIPRFAQISEDSGRLFKKSKEVGLQLQEDLMKVLNELYTVMKTYHMYNMDSINAESKLKEAEKQEEKQMSRSVRHEEKQTPRSPDSLTNIKIEDKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNSCVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEFNVETSKHGGLETIENAAENLE...
Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. Mechanistically, acts by binding and deforming membranes, th...
B0S6J3
B7IDZ1
ENGB_THEAB
Probable GTP-binding protein EngB
Thermosipho
MKIKSVELVKTIYKSNDKYPESLNGEFVFVGRSNVGKSTLLNILTGRNIAKTSKKPGKTASINFYKINNSFYFVDLPGYGYAKVSVEERARWRKIIENYFSKRAWNIKLVFVLIDGRHELQKNDEILLEWLKELELDFAIVMTKMDKLKNSERAKMIRYYKDLYGENYTIIPYSAITREGIDKIYELIEIFGGV
Necessary for normal cell division and for the maintenance of normal septation.
B7IDZ1
B2RYG1
FA32A_RAT
Ovarian tumor associated gene 12
Rattus
MEAYEQVQKGPLKLKGVAELGVTKRKKKKKDKDKAKMLEAMGTSKKNEEEKRRCLDKRTPAQAAFEKMQEKRQMERILKKASKTHKQRVEDFNRHLDTLTEHYDIPKVSWTK
May induce G2 arrest and apoptosis. May also increase cell sensitivity to apoptotic stimuli.
B2RYG1
A0A072TH68
KI104_MEDTR
Kunitz type trypsin inhibitor 104
Medicago
MSTRSLTIFILAHVWLLMATTSIAQFVIDTSGEPVEDDEEYFIRPAITGNGGGSTLVTGNGPCPLHVGLDNTEGTLGVAVKFTPFAPQHDDDDVRLNRDLRVTFLTSTSCGQSTDWRLGEKDATSGRRLIVTGRDNGAGSQGNFFRIVQTQTGGTYNIQWCPTEACPSCKVQCGTVGVIRENGKNLLALDGDALPVVFQKE
Protease inhibitor involved in the control of mycorrhiza establishment and arbuscule development during root colonization by arbuscular mycorrhizal (AM) fungi (e.g. Rhizophagus irregularis).
A0A072TH68
Q91169
PIT1_ONCKE
Growth hormone factor 1
Oncorhynchus
MSCQAFSADSFTTLAGDSLPLLMHHASAADCLPSSASTHTHNMVSAVPSGLSLLQSSKRSHMHLSTSTLGNGPPGLHYPVTPCHYSNQQTTYGMMAAQEMLSASISQTRILQTCSVPHPNMVNGANTLQGSLAPCLYKFPEHGLGGGSCSLSHSFPPLPPAVLSEEPPLGGTKDLRLRSRPPDDPPDMDSPQIRELEKFANNFKLRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACTLKAILAKWLDEAEQAGALFNEKMGMNERKRKRRTTISLGAKEALERSFREKIKPSSQEIVRMAEGLHLEKE...
Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'.
Q91169
Q7VPP6
ATP6_HAEDU
F-ATPase subunit 6
Haemophilus
MAVNTAEYIGHHLSFLSSGDGFWAVHLDTLFFSLVAGVLFLVVFSRVAKNATTGVPGKLQCLVEMVVEWVDGLVKDNFHGPRHMIAPLALTIFCWVFIMNAIDLVPVDFLPQLANMFGIHYLRAVPTADISATLGMSICVFGLILFYTVKSKGFNGLAKEYTLHPFNHWAFIPVNFILETVTLLAKPISLAFRLFGNMYAGELIFILIAVMYMADNFALQALGIPLHLVWAIFHILVITLQAFIFMMLTIVYLSIAYNKADH
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Q7VPP6
Q0I239
GLPB_HAES1
Anaerobic glycerol-3-phosphate dehydrogenase subunit B
Histophilus
MKFDVVIIGGGLAGLTCGIMLQQKGKCCAIINNGQSAMNFSSGSMDLLSQLPNGEKINSFEQGYDSLEEQLPNHPYCLFGKQHVLQKAKQFEQLIEKINLNVTGSYKQNHFRVTPLGGLHRTWLSADCIPTMDLHDEHFGYQKITVLGIEGYHDFQPHLLAENLIQHPQFTHCSITTALLHLPELDQLRLTSREFRSVNISQLLEHRLAFRELVQEIKQASGDGEAIFLPACFGLDNQDFFNKLTLETGLNLYELPTLPPSLVGLRQHKKLKTYFEKLGGFILNGDKALRAVIEDQQVKQIYTQLHQEHGIFAEHFVLAS...
Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.
Q0I239
Q6AP72
RS10_DESPS
30S ribosomal protein S10
Desulfotalea
MMIPTEKIRIRLKAYDHKLLDQSTSEIVETARRTGSAVVGPIPLPTSINKFCVLRSPHVNKKSREQFEMRTHRRLLDILEPTQQTIDLLMKLELSAGVDVEIKLP
Involved in the binding of tRNA to the ribosomes.
Q6AP72
Q8BHM9
TM11F_MOUSE
Airway trypsin-like protease 4
Mus
MMYAPVEFSQTAYPRIEYQRRQQQFWDPIRLALFTLAIVAIVGITIGIVTHFVVEDDKSFYYLASFQVTSIKYRENYGIRSSREFIERSHQIERMMSRIFRRSSGVGRFIKSHVIKISPDEQGVNILIVLMFRYPSTDSAERIKKRIERTFYQSLKIKQLPLTISMPSFSLTPIDSKKMRNLLNSRCGIRMSSSNIPLPASSSTERIVQGRETAMEGEWPWQASLQLIGAGHQCGATLISNTWLLTAAHCFWKNRDPTKWIVTFGTTITPPLVKRSVGKIIIHEEYHRDTNENDIALAQLTTRVEFSNVVQRVCLPDSSM...
Probable serine protease.
Q8BHM9
A3CYP1
COAD_SHEB5
Pantetheine-phosphate adenylyltransferase
Shewanella
MHTRAIYPGTFDPITNGHADLIERAAKLFKHVVIGIAANPSKQPRFTLEERVELVNRVTAHLDNVEVVGFSGLLVDFAKEQKASVLVRGLRAVSDFEYEFQLANMNRRLSPDLESVFLTPAEENSFISSTLVKEVALHGGDVNQFVHSEVATALAAKLKLAKP
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
A3CYP1
Q8CPP4
FOLD_STAES
Methenyltetrahydrofolate cyclohydrolase
Staphylococcus
MVAKILDGKQIAKEYRQRLKNQVNDLKEYGFTPKLSVILVGNDGASQSYVKSKKKAAEKIGMISEIIHLDESTSEEVVLSELNRLNNDDTVSGILVQVPLPKQVSEQKVLEAINPEKDVDGFHPINIGKLYIDEQTFVPCTPLGIMEILKHADINLEGKNAVVIGRSHIVGQPVSKLLLQANATVTILHSRTKNMNAHLKQADVIVSAVGQPGLVTKENVKKGAVIIDVGNTPDENGKLKGDVAYDEVKEIASAITPVPGGVGPLTITMVLNNTLLAEKLRRGLTK
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q8CPP4
P82451
ABCC9_RABIT
Sulfonylurea receptor 2
Oryctolagus
MSLSFCGNNISSYNIYDGVLQNPCFVDALNLVPHVFLLFITFPILFIGWGSQSSKVQIHHNTWLHFPGHNLRWILTFALLFVHVCEIAEGIVSDSRRESRHLHLFMPAVMGFVATTTSIVYYHNIETSNFPKLLLALFLYWVMAFITKTIKLVKYWQSGWGVSDLRFCITGIMVILNGLLMAVEINVIRIRRYVFFMNPQKVKPPEDLQDLGVRFLQPFVNLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYEEQKKKAADHPNRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISG...
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.
P82451
Q3L6T9
NU4LM_MARAM
NADH dehydrogenase subunit 4L
Martes
MSMVYINIFLAFILSFMGLLIYRSHLMSSLLCLEGMMLSLFIMMTVTILTNHLTLASMTPIILLVFAACEAALGLSLLVMISNTYGTDYVQNLNLLQC
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
Q3L6T9
A9WL37
BIOB_RENSM
Biotin synthase
Renibacterium
MLSGVELSRDEALVLLRSDPANYLSLLAAAARLRSAYFGNSVKLNYLVNLKSGLCPEDCTYCSQRLGSAAQILKYSWLKSEDAIDQAEQGLAGGASRVCFVASGRGPSDRDVDRVAGLVGDFKTRNPQAEVCACLGILKEGQAERLKSCGVDAYNHNLNTSEEKYSEICTTHEFSDRTNTVKAAKAAGLSPCSGLIVGMGESDEELIDALFALRELGSESVPVNFLMPFEGTPLADTWLLTPVKCLQILCVARFVAPRSELRIAGSREMHLRSLQPLALHVANSIFLGDYLTSEGQSAAEDLAMIEDGGFVILDPRASAP...
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
A9WL37
B4SZJ8
BIOF_SALNS
8-amino-7-ketopelargonate synthase
Salmonella
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAATRFGVGSGGSGHISGYSVAHQALEVELAQWLEYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCVGQQLVVTEGVYSMDGDSAPLAEIQHIARRHHAWLLVDDAHGIGVTGDEGRGTCWQRGVKPELLVVTFGKGFGVSGAAVLCSESVADYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGRERREKLAALVQRFRAGVNASRFTLLNAHSAI...
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
B4SZJ8
Q5SCY7
TI214_HUPLU
Translocon at the inner envelope membrane of chloroplasts 214
Huperzia
MLSVLWVLISWINISGPIPNISGSLTLFGLYYGFLAALPIGLSQILTIRAFLLGGNTGGTLAVSGSIMGQLITNLSIYYWPIYVMLLKPHAITLLVLPYMLFYWYRTKDLLYDQPPNPVESLNDAQVRQIFLDSFILSLLNPVILPSPVFARSLNLFIFRYSNKISFVISSSFGWLGGYILFINLIKLLMVRIERDSSVNYPLIKSIINQIFSIIILALRLLYLGRAPVPLFTKKIHDGFESDENQIVKSLWLNKPWPTVLFDYRKWNRPFRYIQNGPNGDSPVKKQVSQYFFDTCSSDGRQRISFTSLPSSSTFQKDLK...
Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
Q5SCY7
B8CRF7
CLPP_SHEPW
Endopeptidase Clp
Shewanella
MHKAPESVLNALVPMVVEQTAKGERSYDIYSRLLKERVIFLVGQVEEHMANLIVAQLLFLESESPDKDIYLYINSPGGSVTAGMAIYDTMQFIKPNVSTVCIGQAASMGAFLLAGGAEGKRHCLPNSRVMIHQPLGGFQGQASDIAIHAQEILGIKNKLNTMLAEHTGQPIEVIERDTDRDNFMSADEAAEYGLVDSVLAKRG
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
B8CRF7
O93631
RS7_METBU
30S ribosomal protein S7
Methanococcoides
MYKLFGKWDLTEVEVADAGIKRYVNLDPVIVPHTSGKHARQQFNKSDITIVERLVNNVMRNAQNTGKKQIALRIVDEAFDIVNSKTKKNPVQVLVEAVSNAGPREEVVRLKYGGISVPKAVDTAPQRRVDHALRNISIGSNQTAFKSKRSAAECLASELIAASNRDAKCFSINRKDGKERVAKAAR
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.
O93631
A8IFY6
AROE_AZOC5
Shikimate dehydrogenase (NADP(+))
Azorhizobium
MKRVAIFGHPVIHSRSPLVHGYWLKQHGIAGDYVRHDVAPDEAEAFFARFAEQGYAGGNVTIPHKEVAFNALAEADPVARALGVANTLWLEDGRLFGANTDAPGFLSNLDVTAPGWDANPRVALVLGAGGASRAVLYGFLQRGFDKVLLANRTLARAEALAAHFGPRVVPIGWDGVSASLKEAQVVANTTSLGMKGQPPLDLDLSVLADDAVVADVVYVPLETPLLKAAKARGLRTVDGLGMLLHQAVPGFARWFGVTPQVDAGLRDLIVADLAAKGQLGA
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
A8IFY6
P0DUJ7
SSEK3_SALTS
Salmonella secreted effector K3
Salmonella
MFSRVRGFLSCQNYSHTATPAITLPSSGSANFAGVEYPLLPLDQHTPLLFQWFERNPSRFGENQIPIINTQQNPYLNNIINAAIIEKERTIGVLVDGNFSAGQKKALAKLEKQYENIKVIYNSDLDYSMYDKKLSDIYLENIAKIEAQPANVRDEYLLGEIKKSLNEVLKNNPEESLVSSHDKRLGHVRFDFYRNLFLLKGSNAFLEAGKHGCHHLQPGGGCIYLDADMLLTGKLGTLYLPDGIAVHVSRKGNSMSLENGIIAVNRSEHPALKKGLEIMHSKPYGDPYIDGVCGGLRHYFNCSIRHNYEEFCNFIEFKHE...
Protein-arginine N-acetylglucosaminyltransferase effector that disrupts TNF signaling in infected cells, including NF-kappa-B signaling and apoptosis . Acts by catalyzing the transfer of a single N-acetylglucosamine (GlcNAc) to a conserved arginine residue in the death domain of host proteins such as TRADD, TNFRSF1A/TN...
P0DUJ7
P08238
HS90B_HUMAN
Heat shock 84 kDa
Homo
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKH...
(Microbial infection) Binding to N.meningitidis NadA stimulates monocytes . Seems to interfere with N.meningitidis NadA-mediated invasion of human cells (Probable).
P08238
Q5E963
ARP5L_BOVIN
Arp2/3 complex 16 kDa subunit 2
Bos
MARNTLSSRFRRVDIDEFDENKFVDEQEEAAAAAGEPGPDPSEVDGLLRQGDMLRAFHAALRNSPVNTKNQAVKERAQGVVLKVLTNFKSSEIEQAVQSLDRNGIDLLMKYIYKGFEKPTENSSAVLLQWHEKALAVGGLGSIIRVLTARKTV
May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Q5E963
B8FA41
TRPD_DESAL
Anthranilate phosphoribosyltransferase
Desulfatibacillum
MFSELLKKIVSGQDLAEDETTTMMDAIMSGEVEVPAIAAFMAALATKGETFTELAGAARSMRRKATRIQVSSNTVVDTCGTGGDGASTFNISTTSAFVVAGCGVTVAKHGNRSVSSKCGSADVLEALGVKLDTHPEVVEQGIEEIGIGFLFAPMYHSAMRFAMPARQAVGIRSIFNMLGPLTNPAGANCQLLGVYDPKLTEMFAEALKLLGARKAYVVHGHDGLDEISICAPTRVSELAEGMVRTFDILPEQLNIEACDISELAGGDAEENAGITKSILEGTPGPKQDVVVVNAGAALVAAGVAEDFKDGMAKAKEAIQS...
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
B8FA41
Q7MUR5
RISB_PORGI
6,7-dimethyl-8-ribityllumazine synthase
Porphyromonas
MATAYHNLSDYDYESVPCGKDLRIGIAVAEWNHNITEPLMKGAIDTLLEHGVSADNIIVQHVPGTFELTYASAYLAEQHEVDAVIAIGCVVRGDTPHFDYICQGVTQGITQLNIDGFVPVIFGVLTTETMLQAEERAGGKHGNKGTEAAVTALKMAGLERI
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Q7MUR5
Q1QQP6
TSAD_NITHX
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Nitrobacter
MLVLGIETTCDETAAAVVERHADGSALILSNIVRSQTGEHAPYGGVVPEIAARAHVDMLDGIIASAMKQSGVGFPRLSGVAAAAGPGLIGGVIVGLTTAKAIALVHRTPLIAVNHLEAHALTPRLTSALEFPYCLFLASGGHTQIVAVLGVGNYVRLGTTVDDAMGEAFDKVAKMLGLPYPGGPQVERAAADGDAKRFNFPRPMLGRPDANFSLSGLKTAVRNEAGRIDPLRPRDINDLCAGFQAAVLEATADRLGVGLELFRERFGTPRALVAAGGVAANQAIRGALEGVAARAQTMLIIPPPALCTDNGAMIAWAGAE...
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct ca...
Q1QQP6
P50253
COX2_DROSI
Cytochrome c oxidase polypeptide II
Sophophora
MSTWANLGLQDSASPLMEQLIFFHDHALLILVMITVLVGYLMFMLFFNNYVNRFLLHGQLIEMIWTILPAIILLFIALPSLRLLYLLDEINEPSVTLKSIGHQWYWSYEYSDFNNIEFDSYMIPTNELTTDGFRLLDVDNRVILPMNSQIRILVTAADVIHSWTVPALGVKVDGTPGRLNQTNFFINRPGLFYGQCSEICGANHSFMPIVIESVPVNHFIKWISSNNS
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII...
P50253
Q6AFZ2
SYV_LEIXX
Valyl-tRNA synthetase
Leifsonia
MPEKPALEGLEGKWGSRWQEDGTYLFDRAAAIAAGRDAVYSIDTPPPTASGSLHIGHVFSYTHTDVVARFQRMLGKRVFYPMGWDDNGLPTERRVQNYYGVRCDPTLPYEPGLTPPFEGGDNKSSKAADQKPISRRNFIELCERLTVEDEKQFEALWRSLGLSVDWSQTYRTIGEESLRTSQLAFLRNVKRGEAYQALAPTLWDITFRTAVAQAELEDRDQPSAYHRVAFHGEAGPVFIETTRPELLPACVALVAHPDDERYQPLLGTTVRTPVFGVEVPVVAHHLAQPDKGSGIAMICTFGDITDVTWWRELDLPNRAI...
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Q6AFZ2
Q7VQN8
RS18_BLOFL
30S ribosomal protein S18
Candidatus Blochmannia
MSILPRYIRHRKFCRFTADKCIYVDYKDLSKIQHSIIENAKIIPSRITGTRSKYQRQLARAIKIARFLSLLPYIDQNR
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Q7VQN8
Q57YZ9
SIR4_TRYB2
SIR2-related protein 2
Trypanosoma
MADRLAIFIKQCGLQRCVILTGAGCSTESGVPDYRGPNGLYRRPNFVPLTRQVFLSGSEHRKRYWARSMFGYNTVSGASCNDTHMGLYELYRAGVVNRLLTQNVDGLHHLAAHGGTGSKTVEAYAKYTSSNSGVLELHGNIHQVCCMQCGDVSPRRRLQQRLCEANYQLCRDYEAEFSEVRPDGDYEVPDRVVQAMQLVCCEHCGGLLKPHVVLFGENVPKECVREAYTAVRAASCLICLGTSLQVFSALRFVLAARESGVPIAIVTAGRTRADGLEELKVDTNSTAATMRGVVKQLLGFELGGTK
NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues.
Q57YZ9
Q5M865
PAGR1_RAT
PTIP-associated protein 1
Rattus
MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREASRAEEALEASSAVSDERAEGESEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPVTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPASPPLRSSGNSLFPRQRKY
Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where th...
Q5M865
A0LI59
RLMH_SYNFM
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Syntrophobacter
MQIHLVFVGKTVFPDVETGIERYVSRLNHYLPTRIHYVKAEKIPPRGMESAVLEKECERILKLIGGKSNQLIVWDRTGKHLDSLEFARVLERLSNGGTGAVWMIIGGPLGISRELRDRANLVLALSEMTFPHDLARLIVAEQLYRAFTIIRGEPYHK
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
A0LI59
Q58497
DCDA_METJA
Diaminopimelate decarboxylase
Methanocaldococcus
MKIMFLGNDTVEIKDGRFFIDGYDAIELAEKFGTPLYVMSEEQIKINYNRYIEAFKRWEEETGKEFIVAYAYKANANLAITRLLAKLGCGADVVSGGELYIAKLSNVPSKKIVFNGNCKTKEEIIMGIEANIRAFNVDSISELILINETAKELGETANVAFRINPNVNPKTHPKISTGLKKNKFGLDVESGIAMKAIKMALEMEYVNVVGVHCHIGSQLTDISPFIEETRKVMDFVVELKEEGIEIEDVNLGGGLGIPYYKDKQIPTQKDLADAIINTMLKYKDKVEMPNLILEPGRSLVATAGYLLGKVHHIKETPVTK...
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Q58497
Q05095
CDX1_RAT
Caudal-type homeobox protein 1
Rattus
KTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQQQQQQPMPPTQLPLPLDGTPTPSGHPGSLCPTNAGLLGTPSPVPVKEEFLP
Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
Q05095
D4GYE4
PTFA_HALVD
Fructose-specific phosphotransferase enzyme IIA component
Haloferax
MDVTDISTITPLELISLEEPPATKEGAIEFLLDLAVDAGRVDDRDAALDALLEREGEATTGVGFGIGIPHAKTDAVSKPTVAFARSAEGIDFDAMDDKPAKLLFMILVPAAGGEDHLQILSALSRSLMHEDVREKLLEAESKQTVQDVLAEVVE
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II PtfABC PTS system is involved in fructose transport.
D4GYE4
B1KQY9
GRPE_SHEWM
HSP-70 cofactor
Shewanella
MSNDSSKAKQNQVDEAVEGEILTESEVETGNDEASLMDELTQANFRVEELEQALAEANAKIEEQKDSVTRAAASEANIRRRAAQDVEKAHKFALEKFANELLPVIDNMERALQGTNAEAEETKAIYEGVELTLKSFVSTVDKFGLKEVNPHGESFNPEHHQAIGMQPSPEFPANTVMMVMQKGYILNDRLLRPAMVMVSQGGSGVDTQA
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-b...
B1KQY9
Q89AN1
GRPE1_BUCBP
HSP-70 cofactor 1
Buchnera
MNIDNDLLSKNKEAKVVSENSTVEINDVTNSDSKNTDNDFQTEELNNFEKIFLNLNSDLLNQQLLVKNNLKLYKIRAEKEINRAYKFSLKSFISSLFPVIDSMEYALNLFKKDDKILCLIFNELDNVSQSLMNLLVKFGVTSIKDINIAFNPDIHQAITTQVSKDIKNNYVISIMQKGYLLYDRLLRPAMVIVSKNDI
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-b...
Q89AN1
C5C2D6
MNMA_BEUC1
tRNA-specific 2-thiouridylase MnmA
Beutenbergia
MRVLAALSGGVDSAVAAARAVDAGHDVVGVHMALSRTRAQHRTGSRGCCSIEDASDARRAADVLGIPFYVWDLSEEFTDTVVADFLSEYAAGRTPNPCVRCNEHIKFSALLDRGLALGFDAVATGHYARIERGAAGVPELHRAADAAKDQSYVLAVMGPERLARSLFPLGEVPTKDAVRAEAAARGLSVSAKPDSYDICFVADGDTQGFLRSHLGSQPGPVLDTDGREVGAHDGAYAFTVGQRKGLRLPRPAADGRPRYVVDVRTASNTVVVGPAELLSVRDVLGERPVWLAEEPHEWTDATVQVRAHGAALPARIRTVT...
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
C5C2D6
P16044
IBPI_TACTR
BPI-type
Tachypleus
TERGFLDCTSPPVTGPCRAGFKRYNYNTRTKQCEPFKYGGCKGNGNRYKSEQDCLDACSGF
Inhibitor of trypsin and chymotrypsin.
P16044
A9BHP7
AROA_PETMO
5-enolpyruvylshikimate-3-phosphate synthase
Petrotoga
MKIEVTPTENINAEITLPGDKSISHRALIIGSLAEGETKIHNFLSSEDTLSTLNILNSIGASIKQISEDEVIVEGKGKDNFIEPSNVLNAKNSGTTMRLMMGVLSAQNFYSVITGDDSLRERPMKRVIDPLSKMGGRFFARKNGEFAPITILGTKDISPLVYKTPVASAQVKSAILLAALYAKGETQVIEPAKSRDHTERMLKYFGADIAQKDTTVVIRGLTKNLEGREFFVPGDLSSASFFIVAALITKNSTLLIKNVGINPTRTGILSVLKMMGADIKIINEKTLNNEPVGDLLVKSSSLKGVEIKGEMIPLIIDEIP...
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
A9BHP7
Q8PN23
OBG_XANAC
GTP-binding protein Obg
Xanthomonas
MKLVDEAEILVTAGNGGNGCVGFRREKFIPLGGPDGGDGGAGGSVWIVADENVNTLVDFRHERTFKAQRGENGMGRQAYGKGGEDRIIVVPVGTVVINVQTDEVIGDLTQHGDRLLVAKGGKGGLGNMHFKSSVNRAPRQATTGEEGEERLLKLELKLLADVGLLGFPNAGKSTLIRAVSAATPKVADYPFTTLYPNLGVVSVEAYRSFVIADVPGLIEGAADGAGLGTQFLRHLQRTRLLLHLVDISPALGVYGEGGVDGVSPADQVRTIERELERHDPELLKKPRWLVLNKADLMFEDEARAAAETIVAELGWTAPWY...
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Q8PN23
Q0C643
HIS6_HYPNA
ImGP synthase subunit HisF
Hyphomonas
MLKTRIIPCLDVKDGRTVKGVNFVDLKDAGDPVALARAYDAAGADELCFLDITASHEGRGTLLETVSRTAEACFMPLTVGGGVRSVEDMVALLRAGADKVAINSAAVADPALVSACAAKAGRQCVVVAIDARAVGDSWEIFTHGGRKATGINAVEFAREAAKRGAGEILLTSMDRDGTKSGYDIPLLKAVSSAVTIPVIASGGAGSVEDFAPAVLEGGASAVLAASIFHFGEASLAEARAALAKAGAPVRTV
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Q0C643