accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q5BJJ6
MAT2B_DANRE
Methionine adenosyltransferase II beta
Danio
MPGFNYGGDQDEVYTPYRRVLVTGATGLLGRAVYKEFKNNDWDALGCGYNRARPFFLKCNLLDEDAVRGVIQSFQPHVIVHCAAERRPDVVERHTEAAMNLNVHACATLAKEAGGSFLIYISTDYVFDGRNPPYGENDAPNPLNLYGKSKLEGEREILRHCPGAAVLRVPILFGEVEKVEESAVTVLFERVQEGAESCTIDHCQQRFPTYTNDVARVCRNMAERALQDQSLRGIFHYSAKEQMTKYEMTCAIADAFNLPSSHLIPMTEQPAGAGAQRPQNAQLECSRLELLGLSVESTPFKNAIRDSLWPFQHDKRWRQTVFH
Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro).
Q5BJJ6
P75919
CLSC_ECOLI
Cardiolipin synthase C
Escherichia
MPRLASAVLPLCSQHPGQCGLFPLEKSLDAFAARYRLAEMAEHTLDVQYYIWQDDMSGRLLFSALLAAAKRGVRVRLLLDDNNTPGLDDILRLLDSHPRIEVRLFNPFSFRLLRPLGYITDFSRLNRRMHNKSFTVDGVVTLVGGRNIGDAYFGAGEEPLFSDLDVMAIGPVVEDVADDFARYWYCKSVSPLQQVLDVPEGEMADRIELPASWHNDAMTHRYLRKMESSPFINHLVDGTLPLIWAKTRLLSDDPAKGEGKAKRHSLLPQRLFDIMGSPSERIDIISSYFVPTRAGVAQLLRMVRKGVKIAILTNSLAANDVAVVHAGYARWRKKLLRYGVELYELKPTREQSSTLHDRGITGNSGASLHAKTFSIDGKTVFIGSFNFDPRSTLLNTEMGFVIESETLAQLIDKRFIQSQYDAAWQLRLDRWGRINWVDRHAKKEIILKKEPATSFWKRVMVRLASILPVEWLL
Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) from phosphatidylglycerol (PG) and phosphatidylethanolamine (PE).
P75919
P35654
HRPI_ERWAM
Harpin secretion protein HrpI
Erwinia
MSSLFVWLNRLAISAMQRSEVVGAAIVMSIVFMMIIPLPTGLIDVLIALNICISSLLIVLAMYLPKPLAFSTFPSVLLLTTMFRLALSISTTRQILLQQDAGHIVEAFGNFVVGGNLAVGLVIFLILTVVNFLVITKGSERVAEVAARFTLDAMPGKQMSIDSDLRAGLIEAHQARQRRENLAKESQLFGAMDGAMKFVKGDAIAGLVIVFINMIGGFAIGVLQNGMEAGAAMHIYSVLTIGDGLIAQIPALLISLTAGMIITRVSADGQQVDANIGREIAEQLTSQPKAWIMSAAGMLGFALLPGMPTAVFVIISAIALGSGLFQLWRIKQQDSQQQADELHAQQLAPEDNGYQDLRRFNPTRAYLLQFSQEHLNSEAAESLIQHIRRLRNRLVYHFGFTLPSFDIEFSPALAADEFRFCVYEIPLVTATFAVEQLAVRTSSIEIHLADGESDGQIQPGQAERDEHHWCWLPPQHPLLQQEDRRCWNAQQLIMLRMEQAIHQSGAQFIGLQESKSILNWLESEQPELAQELQRIMPLSRFAAVLQRLASERIPLRSVRTIAETLIEHGQHERDSAALTDFVRIALKEHICHQYQQPNGLNVWLLTPETEELLRDSLRQAQSETFFSLAQEYGINLLNQMRSAFPPYDNHHALILVAQDLRSPLRALLKDEFHAVPVLSFAELTSNVAINVLGRLDLQQSPPELQENDPCMNYAY
Involved in the secretion of harpin; a proteinaceous elicitor of the hypersensitivity response in plants.
P35654
C0QT74
SYDND_PERMH
Non-discriminating aspartyl-tRNA synthetase
Persephonella
MIDKLGDFKRDYFCGELTENNIGDEVRLLGWADSVRDHGGVIFINLRDKEGIIQVVIDPSKSPKEAYEKAKKVRSEYVLAVRGRVQRRPAGTENPKLPTGTIEIAVDELRILNTCDILPFPIEDGISAHEEVRLRYRFLDIRRPEMMKKLILRHEVYQATREYLAGHGFLEVETPMLTKSTPEGARDFLVPARLEKGKFYALPQSPQLFKQILMVSGIDRYFQIVKCFRDEDLRKDRQPEFTQIDFEMSFVDEEDVITVSEGLIHYIFKKVLGIELKLPFKRMSYTEAIERYGTDKPDLRYSLELKDITDIAKDVQFKVFKDTVEKGGIVKGINVKGGSKFSRKEIDDLTEEAKKYGAKGMAWIKINEDGSLQSPIVKFFTEEQINKIKEIMEGENGDLLIFIADSYEITHRVLGFLRKHLAEKLKLIPENVWEFVWVVDFPLVEWDEEEGRLVALHHPFTSPKEEDIDRLDEAIQDKKVALSFRSRAYDLVLNGEEIGGGSIRIHSSHIQKKVFELLGISDEEAEEKFGFLINALKYGAPPHGGLAFGLDRIVALMTGSESIRDVIAFPKTQKGICPLTDAPDFVQEDQLEELGIEVNIPEETV
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
C0QT74
B2HQI2
CLPS_MYCMM
ATP-dependent Clp protease adapter protein ClpS
Mycobacterium
MVVASAPAKPGSVGQQESASRDATASPWVTIVWDDPVNLMTYVTYVFQKLFGYSEPHATKLMLQVHNEGRAVVSAGSREAMEVDVSKLHAAGLWATMQQDR
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
B2HQI2
Q8RA32
DPO3_CALS4
DNA polymerase III PolC-type
Caldanaerobacter
MVPATFLENMQIKKVRVEKKSRKLTVVVSSFSSNAQKLSEFQSFLEESFPSLKEIKIVVESPSLSTVEEVLENWEKVVLELSEEYPSSLSFLKTCDVAKEGQNRITVKAPTYAIYEMAKSSKLDFAIREFLRNRYELNLDVELIFSEEGEEIAEKIIEEDIKAIEEVIQKDEKSKKEKSRSEENRVLLGKEMKAKPISIKDVSAETDEVVIEGEIFSIDFKELKSKVLMVFDITDYTSSILVKTFLTEEKYEILKDEIDVGTFVRLRGNVIYDKYEGDLVIDLKDLELIPPKKRMDLSEEKRVELHLHTQMSTLDAVPSATEVIKRAAEWGHKAVAITDHAVVQAFPEAMEASREYGVKVIYGMEGYMVDDGIPIVTGESEASLEGEFVVFDIETTGLSNINDEIIEIGAVKIKNKKIVDTFETFVNPQIPISSFITKLTGIDESMVKDAPLIEEVLPKFLEFAKGAVLVAHNANFDVSFIKSKAKKLGLTVENTVLDTLELSRHLYQDLKNYKLDTLAEFFEVKLLHHHRAVEDAKATAEIFIKMLEKLQEIGIKSVSEINSVLMEREVDVKKLPVYHVTILVKDQKGLRNLYEIISRSNLEFFHRTPRIPKSLLVKMREGLIIGSACEQGEVFRALVSNLEEKKLEDIINFYDYLEIQPVGNNEFLIERGEVRSVEELKEINRKIYELGKKYNKLVVATGDVHFLDPWDDVYRKILMAGKGYKDADRQPPLYFRTTEEMLMEFEYLGEEAAREVVIENPNKIAEIVEDVKPIPEGTFPPVIEGAEEELRRITLEKAHEIYGDPLPPIVQERLDRELNAIINNGYAVMYVIAQKLVSKSLQDGYLVGSRGSVGSSLVATMSGITEVNPLPPHYVCPKCKHSEFVTDGSFGCGVDMPDKYCPNCGTLMKKDGFDIPFEVFMGFEGDKEPDIDLNFSGEYQPIAHRYTEELFGKGHVFRAGTIGTLADKTAYGYVKKYFEERNLTVHKSEIKRLTMGCTGIKRTTGQHPGGVMVVPKDKSIYDFTPIQRPADAEDTDVITTHFDYHSLSGKLLKLDILGHDDPTVIRMLEDLTGVNARKIPLDDKKTMSLFTSVEALGIDPEELGTPVGTLGLPEFGTKFVRQMLIETRPTTFDELVRISGLSHGTDVWLNNAQDIIREGIATLKEVIAARDDIMLYLISKGMDKKLSFKIMENVRKGKGVTQEEIEEMKKHGVPDWFIQSCQKIKYMFPKAHAVAYVIMAFRIAYFKVYYPEAFYATYFTVRADDFNLDIVLGGKESIKRAIKEIEAKGNNATPKEKNLLTVLEVALEMYLRGIKFTNVDLYRSDAEKFLITEEGLLPPLNSLEGVGIQAAKAIAQERENGKFISIEDFRNRTRVSKTVIEILKQYGCLEDLPESNQLSLF
Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
Q8RA32
Q7VD03
PSBY_PROMA
Photosystem II protein Y
Prochlorococcus
MLNLLVITLPILAAIGWVTLNIQKPAREQWDRQFGDNKPF
Manganese-binding polypeptide with L-arginine metabolizing enzyme activity. Component of the core of photosystem II.
Q7VD03
A7I5Q8
RL18_METB6
50S ribosomal protein L18
Methanoregula
MATGPRYLVAFRRRREGRTDYYQRTKLVVADAPRMVVRRTNRHIIVQLVTAEMEGDKTLVSANSAELEKYGYTGATANTPAAYLTGLLFAAKAKKAGQDSAILDIGLNRATPGARVFAALKGAVDGGLEIPYGESILPSEDRLKGEHIAAYNEKAGDIVKNVEQVAAAIKKELV
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
A7I5Q8
A6KYH6
RL15_PHOV8
50S ribosomal protein L15
Phocaeicola
MNLSNLKPAEGSTKTRKRIGRGPGSGLGGTSTRGHKGAKSRSGYSKKIGFEGGQMPLQRRVPKFGFKNINRVEYKAINLETIQKLAEAKNLTKVGMNDFIEAGFISSNQLVKVLGNGSLTTKLDVEANAFSKSAVAAIEAVGGNAVKL
Binds to the 23S rRNA.
A6KYH6
Q9GZK3
OR2B2_HUMAN
Olfactory receptor 6-1
Homo
MNWVNKSVPQEFILLVFSDQPWLEIPPFVMFLFSYILTIFGNLTIILVSHVDFKLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNICNTRKVISYGGCVAQLFIFLALGSTECLLLAVMCFDRFVAICRPLHYSIIMHQRLCFQLAAASWISGFSNSVLQSTWTLKMPLCGHKEVDHFFCEVPALLKLSCVDTTANEAELFFISVLFLLIPVTLILISYAFIVQAVLRIQSAEGQRKAFGTCGSHLIVVSLFYGTAISMYLQPPSPSSKDRGKMVSLFCGIIAPMLNPLIYTLRNKEVKEAFKRLVAKSLLNQEIRNMQMISFAKDTVLTYLTNFSASCPIFVITIENYCNLPQRKFP
Odorant receptor.
Q9GZK3
B1XSQ3
RL23_POLNS
50S ribosomal protein L23
Polynucleobacter
MSQVRKNDHNLMKVLLGPVISEKATMVAEKNEQVVFQVARDANKSDVKQAVELLFKVQVDSVQIVNQKGKPKRYGRFEGRRDHTKKAYVNLKPGQEISFEAEAN
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
B1XSQ3
A0E2L1
SEY12_PARTE
Protein SEY1 homolog 2
Paramecium
MIKNYGDRYHLIDKKALEDKKLDKDQLVEFVRTSGISDIGKNYNIVSIIGSQSTGKSTLLNQLFGTKFDVQNRQQSVGQTTVGIWLSKDVQNNVVVLDVEGSDSVERKSGENMVENQTALMALAMSHCFIINVFLNALGQHTSCQLSIIKIIMQQNLKLFQQDTVKHIIFVVRDWDEDANYEEASRRLNGYLLNIWNEIPKPDHYKETDFHQLFSVQVVTLVYYKMKKEFIEQTNDLHAKLSNQQDPNFIFKDFDYEKNVRWSDMPQYLSNIWEVISNNKDLNLPNEKILISNMRCQQIKLEALDGVKQLNEDLQNRVRTKLVDNFAQECQTIMNLAFKLYDKDARDYHIEVYKEKEKELKDELVNRFYTYFQKQTEQLKQHYMNTLTENLETLKRESIYNLPDKLNELDLFKLQFEEQLAKSVIQKGLWQEEDHIRYFRQQFDNQLKAFVEAQLATFKQQLDNIIKSECDKIVSSQVLNISSKFWQQIESDYYAMISEKYQKYEVLLTGLRVQQKQIEDYLNKFEEDSFHNLKQVIAVASGRFKDQLFQQFKAQFVRAPDGQPRNWQKLTEEEIFHCYTDARDKVFQLLDSLRIRKIKFIRQQVVLKKKAQTLIISSSQKVQYQISSDADSDDVVLNDVFYTQVKMQLAEDIDVQYQDAIQKHKQDFLQNIPKPFWFLLLFFMYDDVLRWMGNPLFLYPILIILCFVGFCIAIGLHSLPKLAFQWVFRTLNQAVIPIIFGGISKLKGS
Probable GTP-binding protein that may be involved in cell development.
A0E2L1
P19382
SNAI1_XENLA
Protein snail homolog Sna
Xenopus
MPRSFLVKKHFSASKKPNYSELESQTVYISPFIYDKFPVIPQPEILSTGAYYTPLVWDTGLLTTFFTSESDYKKSPISPSSSDDSSKPLDLTSFSSEDEGGKTSDPPSPASSATEAEKFQCNLCSKSYSTFAGLSKHKQLHCDSQTRKSFSCKYCEKEYVSLGALKMHIRSHTLPCVCKICGKAFSRPWLLQGHIRTHTGEKPFSCTHCNRAFADRSNLRAHLQTHSDVKKYQCKSCSRTFSRMSLLHKHEETGCTVAH
Transcriptional repressor. Acts upstream of snai2/slug, zic5 and other neural crest markers in the specification of the neural crest and neural crest migration. Involved in embryonic mesoderm formation.
P19382
Q8ECU9
TRPA_SHEON
Tryptophan synthase alpha chain
Shewanella
MNSISNQTIPHQASRYQAAFSRLKAEGRGAFVPFVTLGDPSPELSLKIIDTLVQNGADALELGFPFSDPLADGPVIQGANLRALAAGTTPTACFELLAKIRAKYPELPIGLLLYANLVFANGIDAFYAKAQQAGVDSVLIADVPVEEAAPFIQAAKAHGIAPIFIAPPNADSDTLAKVSQSGEGYTYLLSRAGVTGADTKAGTPVEEILAKLQEFNAPPPLLGFGIAEPAQVSAAIKAGAAGAISGSAVVKIIETHQQDEVKLLAALGEFTRTMKAAT
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Q8ECU9
P0C2L2
GSID_SHIF8
Glutathione transport system permease protein GsiD
Shigella
MRLFNWRRQAVLNAMPLVKPDQVRTPWHEFWRRFRRQHMAMTAALFVILLIVVAIFARWIAPYDAENYFDYDNLNNGPSLQHWFGVDSLGRDIFSRVLVGAQISLAAGVFAVFIGVAIGTLLGLLAGYYEGWWDRLIMRICDVLFAFPGILLAIAVVAVLGSGIANVIIAVAIFSIPAFARLVRGNTLVLKQQTFIESARSIGASDMTILLRHILPGTVSSIVVFFTMRIGTSIISAASLSFLGLGAQPPTPEWGAMLNEARADMVIAPHVAVFPALAIFLTVLAFNLLGDGLRDALDPKIKG
Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane.
P0C2L2
Q74GY0
ATPB_GEOSL
F-ATPase subunit beta
Geobacter
MSQNFGKISQVIGAVIDVEFEPGKLPPIYNALRVTNPAIDDKEYNLVLEVAQHLGENAVRTIAMDSTDGLVRGQAVLDTGKQISVPVGRKTLGRILNVIGEPVDEMGPVNAEKEYGIHREAPAFVDQSTKVEAFTTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIMELINNIAKQHGGFSVFAGVGERTREGNDLWMEMKESGVLDKAALVYGQMNEPPGARARVALSALSIAEYFRDEEGQNVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGELQERITSTTKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLSRQIAELGIYPAVDPLDSTSRILDPQVIGEEHYSIARQVQYVLQKYKDLQDIIAILGMDELSEEDKLVVARARKIQRFLSQPFHVAEAFTGSPGKYVELKDTIKGFQEIVAGKHDDVPEQAFYMVGTIEEALEKAKKLAA
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q74GY0
A8QE76
EFTS_BRUMA
Elongation factor Ts, mitochondrial
Brugia
MIVSRQVIRSVVRKSFNRLCSANVVALPSGSTKEALKELRRKTGYSYVNCRKALNEFGPDNLDEAIKWLKKRAIEEGWEKAAKLGDRPTRQGIVSVMTKGNKAAIVELNCETDFVSRNEDFKRLVEDVTKAVLHAADRDGTSTHGFELLNSNINSLKTSENGMLVKDLITEAIGRLGENITLSRAQLILAPPNVQLFGYAHPKEGTDRVYMGRYVSVVGLKGSNKTDFPTEKLGFQLCQHVVGMRSLTLGTPLPVKKTSVKDEVSQDDEINAFYNGEVTHIDENETQLLRQSFMLNPSQTVHEYVTGHGASIVDFYRTELSSNVSEESFQS
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
A8QE76
B2S533
ARGC_BRUA1
N-acetyl-glutamate semialdehyde dehydrogenase
Brucella
MKPKIFIDGEHGTTGLQIRTRLAERDDLEVISIPEAERRNKDLRADYLRAADIAILCLPDDASKEAVSLLEGHNSTRIIDTSTAHRVHPDWAYGFAELAKGQRERIAEARLVANPGCYPTGAIALVRPLRDAGLLPADYPVSVNAVSGYTGGGKQLIAQMEDRNHPDYLAANNFLYGLPLKHKHVPELQLHGRLDRRPIFSPSVGRFPQGMIVQVPLFLSELEGSPSLAKVHAVLTEHYAGQDIVEVVPLEESAKLPRVDAEELAGKDGMKLFVFGTEDHGQVNLVALLDNLGKGASGAAVQNMNLMLGK
Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.
B2S533
Q8DYT2
MURE_STRA5
UDP-N-acetylmuramyl-tripeptide synthetase
Streptococcus
MITIDKILEILKNDHNFREILFHEHYYYNWTQNVTFNALSYDSRQISSDTLFFAKGATFKKEYLDSAITAGLSFYVSETDYGADIPVILVNDIKKAMSLISMSFYNNPQNKLKLLAFTGTKGKTTAAYFAYHMLKVNHRPAMLSTMNTTLDGKSFFKSHLTTPESLDLFRMMATAVENQMTHLIMEVSSQAYLTKRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFFHKRLLMENSNAVVVNSQMDHFNIVKEQVEYIPHDFYGDYSENVITESKAFSFHVKGKLENTYDIKLIGKFNQENAIAAGLACLRLGVSIEDIKNGIAQTTVPGRMEVLTQTNGAKIFVDYAHNGDSLKKLLAVVEEHQKGDIILVLGAPGNKGQSRRKDFGDVINQHPNLQVILTADDPNFEDPLVISQEIASHINRPVTIIIDREEAIANASTLTNCKLDAIIIAGKGADAYQIIKGNRDNYSGDLEVAKKYLKR
Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Q8DYT2
Q5WES3
RL21_ALKCK
50S ribosomal protein L21
Alkalihalobacillus
MYAIIETGGKQIKVEEGQEIYVEKLDAEAGEEVSFDKVLFVGGESAKVGAPFVEGASVTGTVEKHGRNKKIIVYKMKAKKNYRRKQGHRQPYTKVVIGKING
This protein binds to 23S rRNA in the presence of protein L20.
Q5WES3
Q91XI1
DUS3L_MOUSE
tRNA-dihydrouridine synthase 3-like
Mus
MAETAAESGGGGDSGVGACERGVAPIKAQYRTTKERFHEYLDGDKQEGACQEVPTGDPAEPGAKRIRLEDGQENGKTEVAIESRERQVPKRARGQNKSRPHVKPAHYDKDRLCPSFLQEPATPCAFGDRCRFLHDVGRYLETKPADLGPRCVLFETFGRCPFSMTCRFAGAHLGPEGQNLVQEEVVARCAQLPSVRNGLDRALQQQLRKRQVCFERAEQALNRLTQSPMPTVVPETTVAMATPKQNSCHAQLDTVGGAGTPQSSPVPTCGPLTDEDVIRLRPCEKKRLDISGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHPCEDIFGVQLEGAFPDTMTKCAELLNRTIDVDFVDINVGCPIDLVYKKGGGCALMNRSAKFQQIVRGVNGVLDVPLTVKMRTGVQERVSLAHRLLPELRDWGVALVTLHGRSREQRYTRLADWPYIEQCAKVASPMPLFGNGDILSFEDANCAMQTGVAGIMVARGALLKPWLFTEIKEQRHWDISSSERLDILRDFTHYGLEHWGSDTQGVERTRRFLLEWLSFLCRYVPVGLLERPPQRINERPPYYLGRDYLETLMASQQAADWIRISEMLLGPVPPGFVFLPKHKANAYK
Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs. Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation.
Q91XI1
P97738
NPTX2_RAT
Neuronal pentraxin II
Rattus
MLALLTAGVALAVAAGQAQDNPIPGSRFVCTALPPEAARAGCPLPAMPMQGGALSPEEELRAAVLHWRETVVQQKETLGAQREAIRELTSKLARCEGLAGGKARGTGATGKDTMGDLPRDPGHVVEQLSRSLQTLKDRLESLELQLHTNASNAGLPSDFREVLQRRLGELERQLLRKVAELEDEKSLLHNETSAHRQKTENTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKIKKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQLPLFVSDGKWHHICITWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVGGRFDATQAFVGELSQFNIWDRVLRAQEIINIANCSTNMPGNIIPWVDNNVDVFGGASKWPVETCEERLLDL
Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner.
P97738
C3KYH5
RF1_CLOB6
Peptide chain release factor 1
Clostridium
MLERLNFIENKYEELSNKISDPSVMANQKEWQKLCKEHADLEIIVNTYREYKKAQEDLESDKEMLKEESDKDLREMAQEEIKELTLKLEDLERELTILLLPKDPNDDKDVFIEIRAGAGGEEAALFASNLLRMYTRYAERKNWKVETMSLNATDIGGFKEVTVAIKGKGAYSRLKYESGVHRVQRVPDTESSGRIHTSTATVAVLPEVDDVDININANDLRIDVYRASGHGGQCVNTTDSAVRITHLPTGLVVTCQDEKSQLKNKEKAMKVLKARLFEAAEAERAASIAEDRKSQVGTGDRSERIRTYNYPQGRITDHRIGLTLYKLETFLDGDIDEVIEALVTEDQAEKMKDLGRVN
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
C3KYH5
B2HQH3
MURI_MYCMM
Glutamate racemase
Mycobacterium
MSSPLAPVGIFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYGPLTIPEVRAHALAIGDDLVGRGVKALVIACNTASAACLRDARERYDVPVVEVILPAVRRAVATTRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVLGLAEGYLEPLQRSGVDTLVLGCTHYPLLSGLIQLVMGDNVTLVSSAEETAKEVLRVLTERDILRPHDAPPATRLFEATGDPEAFMALAARFLGPALTGVQPVRPSGMH
Provides the (R)-glutamate required for cell wall biosynthesis.
B2HQH3
Q91W27
TIP39_MOUSE
Parathyroid hormone 2
Mus
METCQMSRSPRERLLLLLLLLLLVPWGTGPASGVALPLAGVFSLRAPGRAWAGLGSPLSRRSLALADDAAFRERARLLAALERRRWLDSYMQKLLLLDAP
Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits.
Q91W27
Q7MWS9
YBEY_PORGI
Endoribonuclease YbeY
Porphyromonas
MAKINFYAEGVSLPRIRRRIVGKWIAEVCSRYGKAVGEISYLFCDDEYILKANQEFLDHDYYTDIITFDSCEADTVNGDLLISLDTVRSNARALDLRYEDELHRVIIHGILHLCGLKDKSKKDEAQMRAAEEKALVMLRETIGSELSLLHT
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q7MWS9
B1P1D0
JZ13B_CHIGU
Peptide F5-18.88
Chilobrachys
MKTSVLFVIFGLALLLCLSFAAELEDTGRQCGEFMWKCGAGKPTCCSGYDCSPTWKWCVLKSPGRR
Probable ion channel inhibitor.
B1P1D0
B8AFR8
ORR11_ORYSI
OsRR11
Oryza sativa
MSSIGAGAGGAVVGAAVAAVAVGGGAPPHVLAVDDSSVDRAVIAGILRSSRFRVTAVDSGKRALELLGSEPNVSMIITDYWMPEMTGYELLKKVKESSKLKKIPVVIMSSENVPTRISRCLEEGAEDFLVKPVRPSDVSRLFSRVLP
Functions as response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Type-A response regulators seem to act as negative regulators of the cytokinin signaling.
B8AFR8
J9VJ99
PFA4_CRYNH
Protein fatty acyltransferase 4
Cryptococcus neoformans species complex
MAARNWSRVWVGGTVILISFIAFSSQIFVIWPWYGREISLDLLMLLVPLNLAAFMIFWNYRLCVITSPGTVPEGWRPNIGAMDGMEVKKGTHTPRYCKNCAHYKPPRAHHCRQCKTCWLKLDHHCPWIGNCVGFYNQGHFIRFLLWVDIGTTFHLIIMVRRVLYIAEYYHEPTLADVLFLVFNFATCVPVWLCVGMFSIYHVYLACGNSTTIEGWEKDKVATLIRRGKIKEVKYPYNIGIYKNIKSVLGPNPLLWLWPQKMQGDGLSFPVNPSAGDHMTQYFWPPQDPSRLPNPPPIPAHASPFVYGNNGFNPNLRPTNSLRARRSSTPRIDEDEYSHEQGRHYSSGDERDNGSISASSSPEPYLSDYDHYDEGPMYPGERMTTLVPRVRRGSEGWEVAPGGGWNAYAGMMDEEVGWDDEAGYDEAPGEDPYVERPWEMRGRYNVYDPEEESGYTH
Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function. Responsible for the modification of a subset of proteins that are critical in cryptococcal pathogenesis, with substrates involved in cell wall synthesis, signal transduction, and membrane trafficking. Palmitoylates chitin synthase CHS3.
J9VJ99
B9L7E1
BIOB_NAUPA
Biotin synthase
Nautilia
MKKIYLCAISNIRSGACNEDCKFCTQSVKWGADINRYKQKDLKTIVNEAKLAKKNGATGFCLVTSGKGLDDKTLEYVCSAAKSVIKEVDISIIACNGTAGKDSLKELKKAGVKIYNHNLETSREYYPKICSTHTWDERFETCENIKSVGLQLCCGGIFGMGESNEDIESFIRSLKELKPNGIPLNFFIENEKLPLKATHNKDFALKTVKRFANEFKEAIIMLAGGREIVFGNEWTEALKVGANSIVIGDYLTTKGERPDRDLEILLNEGFEIANEC
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
B9L7E1
O24933
HRCA_HELPY
Heat-inducible transcription repressor HrcA
Helicobacter
MLRRIKVGSNLNKKESLLDAFVKTYLQILEPISSKRLKELADLKISCATIRNYFQILSKEGMLYQAHSSGARLPTFKAFENYWQKSLRFETLKVNEKRLKSASENFGLFTLLKKPSLERLERVIECEKRFLILDFLAFSCALGYSVKMEKFLLELVGRSVKEVRSIAASFNALSLARQLERLEYSNTQITRFNLMGLKTLLNSPLFFDILGGKVLERLSKGLHFIEPDCMLVTRPVEFQNKRMQLLCVGKLECDYEGFFQTISEEE
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
O24933
B2UBP3
DNAK_RALPJ
Heat shock protein 70
Ralstonia
MGKIIGIDLGTTNSCVAIMEGNTPKVIENAEGARTTPSIIAYMEDGEILVGAPAKRQAVTNPKNTLYAVKRLIGRKFEEKEVQKDIGLMPYSIVKADNGDAWVEVRGQKLAPPQISAETLRKMKKTAEDYLGEEVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAFGLDKNEKGDRKIAVYDLGGGTFDISIIEIADVDGEKQFEVLSTNGDTFLGGEDFDQRIIDYIIGEFKKEQGVDLSKDVLALQRLKEAAEKAKIELSSTQQTEINLPYITADASGPKHLNLKITRAKLEALVEDLIARTIDPCRTAIKDAGVKVSDIHDVILVGGMTRMPKVQEKVKEFFGKEARKDVNPDEAVAVGAAIQGQVLGGDRTDVLLLDVTPLSLGIETLGGVMTKMIGKNTTIPTKFSQTFSTADDNQPAVTIKVYQGEREMASGNKMLGEFNLEGIPPAPRGTPQIEVSFDIDANGILHVGAKDKATGKENKITIKASSGLSEAEIERMVKDAEANAEEDKKLRELVDSRNQGEALVHSTKKALGEYGDKLEAGEKDKIEAAIKELEETLKGTDKAAIDAKTEALATASQKLGEKVYADMQAKGEAGGAEQAAGAQAGAQAGQGAPHDDNVVDAEFKEVNDKK
Acts as a chaperone.
B2UBP3
B1JUW8
MUTS_BURCC
DNA mismatch repair protein MutS
Burkholderia cepacia complex
MTTLSPEAFAGHTPMMQQYLRIKADHPDTLVFYRMGDFYELFFEDAEKAARLLDLTLTQRGASAGTPIKMAGVPHHAVEQYLAKLVKMGESVAICEQIGDPATSKGPVERKVVRVVTPGTLTDAALLSDKNDVYLLAMCTGHNKRGVAVNIGLAWLNLASGALRLAEIEPDQLAAALERIRPAEILTPDGATDAIPAGAGASKRVPAWHFDIASGTQRLCDQLDVASLDGFGAHSLTSACGAAGALLLYAAATQGQQLRHVRSLKVENETEYIGLDPATRRNLELTETLRGTESPTLYSLLDTCCTTMGSRLLRHWLHHPPRASVAAQSRQQAIGALLDAPANASLDALRSALRQIADVERITGRLALLSARPRDLSSLRDTFAALPALRERISAIVANADALARVDAALAPPAECLDLLTSAIAPEPAAMVRDGGVIARGYDAELDELRDISENCGQFLIDLEARERARTGIANLRVEYNKVHGFYIEVTRGQTDKVPDDYRRRQTLKNAERYITPELKTFEDKALSAQERALARERALYDSVLQALLPFIPECQRVASALAELDLLAAFAERARALDWVAPTFTDEIGIEIEQGRHPVVEAQVEQFIANDCRFGTERKLLLITGPNMGGKSTFMRQTALIALMAYVGSYVPAKSACFGPIDRIFTRIGAADDLAGGRSTFMVEMTEAAAILNDATPQSLVLMDEIGRGTSTFDGLALAWAIARHLLAHNACYTLFATHYFELTQLPAEFPQAANVHLSAVEHGHGIVFLHAVNEGPANQSYGLQVAQLAGVPAPVIRAARKHLAYLEQQSASQHTPQLDLFSAPPAAVDDLECADAPALPDTPHPALEKLRDIDPDDLKPREALDLLYELRTLVRSHDADGHA
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
B1JUW8
B8E003
RF1_DICTD
Peptide chain release factor 1
Dictyoglomus
MLQKLVIDKLEEIEKRFEEIEGLLAKEDVISDFNKYQSLLKERAKIEEIVDKFREYKRLLKEKEDLEEMVKEEQDEDLRSLAETELEDIQEKLEKVEFELKALLLPKDPNDEKNIIMEIRAGTGGEEAALFAADLFRMYLGYAQKKGWKVEIVSSNPTGLGGFKEIIFIVEGKGAYSRLKFESGVHRVQRVPITESSGRIHTSTATVAVLPEMEEIEVEIDPKDLRIETFRSGGAGGQHVNKTESGVRITHIPSGIVVQCQDERSQHQNREKAMKVLRARLYEYYQREKENEIASQRRQQVGTGERSEKIRTYNFPQRRVTDHRINYSSFQLEEVLSGELDEFIDRLILAEKEEQIKKLFEEVGATS
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
B8E003
C5A285
RL4_THEGJ
50S ribosomal protein L4
Thermococcus
MKVKVFNLEGEPVEEIELPKVFSTPFRPDLIRRAVIASWTHRIQPQGRDPLAGKRRVTENIGKGHGMARVERIKTPPRFAAFVPFARGGRRTHPPKVEKIIWEDINKKERRLAIMSAIAATANPDLVRARGHVVDNVPAFPLVVVDDLQKVFKTAQTREIFKKLGIWDDIERAKRNTKIRAGKGKMRGRRYKKAKGPLIVVAKNEGIVQGARNHPGVDVVTVDNLGVELLAPGTHPGRLTIWTKGAIERLKEIYG
Forms part of the polypeptide exit tunnel.
C5A285
Q9QUT0
RHAG_MOUSE
Rhesus blood group family type A glycoprotein
Mus
MRFKFPLMAISLEVAMIVLFGLFVEYETPQNASQKNASHQNASQQGNTSSSAKKDQFFQLYPLFQDVHVMIFVGFGFLMTFLKKYGFSGVGFNLFLAALGLQWGTIMQGLLHSHGKEFHFGIYNMINADFSTATVLISFGAVLGKTSPIQMLIMTILEIAVFAGNEYLVTELFEASDTGASMTIHAFGAYFGLAVAGVLYRPGLRCEHPNDESVYHSDLFAMIGTLFLWIFWPSFNSAIADPGDHQYRAIVNTYMSLAACVITAYALSSLVERRGRLDMVHIQNATLAGGVAVGTCADMEIPLYAAMTIGSIAGIISVLGYKFFSPLLANKLMIHDTCGVHNLHGLPGVFGGLASIVAISWGMSTASMAMQAAALGSSIGSAIVGGLLTGLILKLPIWNQPPDEYCYDDSVSWKVPKFRELDNRFFQHANHNHVEHEV
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.
Q9QUT0
Q1QY21
PURA_CHRSD
IMP--aspartate ligase
Chromohalobacter
MGKNVVVLGTQWGDEGKGKVVDLLTESAATVVRFQGGHNAGHTLVIDGEKTVLHLIPSGVLRADKTCVIGNGVVLSPEALMDEIRELEAKGVPVRERLRLSPACPLILPYHVRLDQAREKARGIAKIGTTGRGIGPAYEDKVARRGLRLGDMLHRERFASKLGEVLDYHNFVLTQYHHEAPVDFQRVLDEAMEIAEELRPMVCDTVSLVHDTRKAGENILFEGAQGSLLDIDHGTYPYVTSSNTTAGGTATGSGVGPLYLDYVLGITKAYTTRVGSGPFPTELFDEFGRHLAEKGHEFGATTGRARRCGWFDAVALRHAVQINSVSGLCLTKLDVLDGLENIRVCIGYRSKDGETIDTPVDSEGYEVIEPLYQDLPGWSESTLGVKRIEDLPNNARAYISFLEEQTGVPIDIISTGPDRNETIVLRNPFLD
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q1QY21
A5GV87
CCS1_SYNR3
Cytochrome c biogenesis protein CcsB
unclassified Synechococcus
MKSLVLKAAAWLSDLRVAIVLLLLIAACSGLGTAIPQGEPAAFYHERYDAAPWLGVVNGNQLLSWELDHLYTSNWFLLLLAWLGLALLLCSLRRQWPALRASLRWLDYTKPRQLSKLAVATSLDTGDSAAALDQLERQLQQQGWAVRRQQNRLAARRGVIGRVGPLLVHTGLIVFMVGAVVGAFGGQRLERFLAPGRSLELLNPQGDTRLELQLDSFAIQRDPAGRPEQFSSQLLLRDGTGAPAQPAAVSVNHPLRHRGITVYQADWGLAAVTMQLGQSPLLQLPLQTFPELGEQVWGLVLPTRPDGSDPVLLALQSELGPVEVYGADSQQLGLLTVGGESQEILGLPLRIADVMPASGLLIKRDPGVPLVYAGFAITLLGGGLSLIATRQLWAISESGRLHIAGLCNRNLVAFADELPKLGSSAITGAPHDAR
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
A5GV87
Q6ENW6
ATPA_SACOF
F-ATPase subunit alpha
Saccharum officinarum complex
MATLRVDEINKILRERIEQYNRKVGIENIGRVVQVGDGIARIIGLGEIMSGELVEFAEGTRGIALNLESKNVGIVLMGDGLMIQEGSFVKATGRIAQIPVSEAYLGRVINALAKPIDGRGEIVASESRLIESPAPGIISRRSVYEPLQTGLIAIDSMIPIGRGQRELIIGDRQTGKTAVATDTILNQKGQDVICVYVAIGQRASSVAQVVTTFHEEGAMEYTIVVAEMADSPATLQYLAPYTGAALAEYFMYRERHTLIIYDDLSKQAQAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNSLLGEGSMTALPIVETQSGDVSAYIPTNVISITDGQIFLSADLFNAGIRPAINVGISVSRVGSAAQIKAMKQVAGKSKLELAQFAELQAFAQFASALDKTSQNQLARGRRLRELLKQSQSNPLPVEEQVATIYTGTRGYLDSLEIEQVKKFLDELRKHLKDTKPQFQEIISSSKTFTEQAETLLKEAIQEQLERFSLQEQT
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Q6ENW6
Q9LRR9
GLO1_ARATH
Short chain alpha-hydroxy acid oxidase GLO1
Arabidopsis
MEITNVTEYDAIAKQKLPKMVYDYYASGAEDQWTLQENRNAFARILFRPRILIDVSKIDMTTTVLGFKISMPIMVAPTAMQKMAHPDGEYATARAASAAGTIMTLSSWATSSVEEVASTGPGIRFFQLYVYKNRNVVEQLVRRAERAGFKAIALTVDTPRLGRRESDIKNRFTLPPNLTLKNFEGLDLGKMDEANDSGLASYVAGQIDRTLSWKDVQWLQTITKLPILVKGVLTGEDARIAIQAGAAGIIVSNHGARQLDYVPATISALEEVVKATQGRIPVFLDGGVRRGTDVFKALALGASGIFIGRPVVFSLAAEGEAGVRKVLQMLRDEFELTMALSGCRSLKEISRNHITTEWDTPRPSARL
Catalyzes the oxidation of glycolate to glyoxylate, with a reduction of O2 to H2O2 . Is a key enzyme in photorespiration in green plants (Probable).
Q9LRR9
A8H1Q6
NUSB_SHEPA
Antitermination factor NusB
Shewanella
MKPSERRKARRLAVQAIYSWQLSGNNIADVEHEFLTEQDVAGVDIAYFRELLGGVATKKSQLDELITPFVTRPLDEVDPVEKAIVRIATYELTFRKDVPYKVAINEAIELAKAFGAEDGHKFVNGILDKLVARNK
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
A8H1Q6
Q1WU83
EFTU_LIGS1
Elongation factor Tu
Ligilactobacillus
MAKEHYERTKPHVNIGTIGHVDHGKTTLTAAITKVLAEKGLAEASDYASIDAAPEERERGITINTAHVEYETEKRHYAHIDAPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVEYIVVFLNKCDLVDDDELLDLVEMEVRDLLSEYDFPGDDIPVIRGSALKALEGDKDAEAQIMELMDTVDEYIPTPQRPTDKPFLMPVEDVFTITGRGTVASGRIDRGTVKVGDEVEIVGLKDDVVKTTVTGVEMFRKTLDEGEAGDNIGALLRGVDRTQVERGQVLAKPGSIQTHKKFKGEVYVLTKDEGGRHTPFFSNYRPQFYFHTTDVTGVIELPEGVEMVMPGDNVTFTVELIAPVAIEKGLKFTVREGGRTVGAGVVSEIDD
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q1WU83
Q88DV3
GLMM_PSEPK
Phosphoglucosamine mutase
Pseudomonas
MSRKYFGTDGIRGRVGEYPITPDFMLKLGWAAGMAFRKQGHCRVLVGKDTRISGYMFESALEAGLSAAGADVMLLGPMPTPAIAYLTRTFHAEAGIVISASHNPHDDNGIKFFSGQGTKLPDEVELMIEELLDQPMTVVESGKLGKVSRINDAAGRYIEFCKSSVPSSTSFEGLKLVVDCAHGATYKVAPSVFRELGADVTVLHAQPDGLNINEGCGSTHIESLQAAVLVGHADLGIAFDGDGDRVLMVDHTGAIVDGDELLFIIARDLQEHGKLQGGVVGTLMSNLGLELALKDLDIPFVRAKVGDRYVMAELLEREWLVGGENSGHVVCCNHTTTGDAIIAALQVLMALKRRGETLAQARQALRKCPQVLINVRFGASKVDPLEHPAVKEASAKVTEALAGRGRVLLRKSGTEPLVRVMVEGEDESQVRAHAEALAKLVGEVCV
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
Q88DV3
B8G711
EFP_CHLAD
Elongation factor P
Chloroflexus
MAAGTTSDLRNGIVIRYNNDLYQVVEFQHVAPGNWRAFVRMKLKSLTTGKVIEDRVRAGAEIDIVRIERRPMQYLYREGDSFVFMDNDTFDQIPVSAELVGDAVKFMKENETVDLVYDAEKDQIIGVELPIFVNLKVVETTVAVRGDTATNVTKPATLETGAVIEVPAFINEGDVLKIDTRTGEYITRV
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
B8G711
B5Z7D2
MOBA_HELPG
Molybdopterin-guanine dinucleotide synthase
Helicobacter
MKNPIIDNIPCVLLAGGKSSRFITNNIQTNKALMPLKSYSSLLEYQYTRLLKLFKKVIISTKKSYELNAPYLLEKESDLFSPLFGIHNAFLTLQTPYIFFIPIDTPLVSFESIKALCGIKNFSVVYAKSPTKEHYLISLWHQSTLNALNYALKTQNYRLSDLIKNASSTAIHFDKEEEFLNLNTLKDYELAVQILKEGSNG
Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
B5Z7D2
Q0IE26
RL20_SYNS3
50S ribosomal protein L20
unclassified Synechococcus
MARVKRGNVARKRRNKILRLARGFRGSNGTLFRTANQRVMKALCNAYRDRRRRKRDFRRLWIARINAAARMNGVSYSRLIGGLKKADVRINRKMLAQMAVVDPASFANVVNATQG
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
Q0IE26
Q12QI6
GLMM_SHEDO
Phosphoglucosamine mutase
Shewanella
MKQRQFFGTDGIRGKVGAGKMTPELALKLGWAAGRVLSRTGTKKVIIGKDTRISGYLFESALEAGLSAAGLNVLLVGPMPTPAVAYLTRTFRAEAGIVISASHNPYYDNGIKFFSTDGSKLDDAIELEIEAELEKPLTCVESHLLGKAKRIDDAAGRYIEYCKGNFPADQTLEGLKIVVDCAHGATYHIAPSVFSELGAEVIAIGDKPNGTNINHEVGATSMGKICETVLAEGADLGIALDGDGDRIMMVNRKGEVIDGDQILYILAADAQKRGQLKGGVVGTLMSNLGLDLALQALDIPFLRSNVGDRYVMEMLKKNDWRIGGENSGHILDLDHGTTGDGIVAGILVLAAMRRQNATLEQLVEPMKMLPQVLINVRFEGSNNPLDSDLVKSAQREVEQSLGARGRVLLRKSGTEPLIRVMVEGDDHDLVLAHANRIAAAVKLGC
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
Q12QI6
Q8XVE7
TRPD1_RALSO
Anthranilate phosphoribosyltransferase 1
Ralstonia
MTISPQDALTRCIEHREIFHDEMLHLMRLIMRGEMSPVIASALIMGLRVKKETIGEIAAAATVMREFATTVDVPAAILDHFVDIVGTGGDGANTFNISTASMFVAAAAGARIAKHGGRGVSSKSGSADVLEALGVNIMLTPEQVAQSIEAVGIGFMFAPNHHPAMKNVAPIRKELGVRTLFNILGPLTNPAGAPNILMGVFHPDLVGIQVRVMQRLGARHAVVVYGKDGMDEVSLGAATVVGELKDGEVREYEIHPEDYGLQMVSNRGLKVADAEESKAMLLGALENVPGTPREIVTLNAGAALYAANLAGSIGDGITLAREAIASGAARAKVDELVRVTNQFKK
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q8XVE7
C0ZL41
MTNX_BREBN
2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase
Brevibacillus
MSKKLVLFCDFDGTITEKDNIVAIVRKFAPPEWEALTEQILSQKISVQEGVGKLFQLLPSSLRQDIIDFIVHEATIRPGFAEFVSYCREEGIELLITSGGIDFFLEPILAPFDLADVPIYCNGSDFSGERITITWPNACDEHCTNGCGMCKTTIIRRYDPATHFRIVIGDSITDLAGAKIADYVIARSFLADKAEELQLPHSTFATFHDVIRILQQVQQEVV
Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
C0ZL41
A4STA4
ZAPB_AERS4
Cell division protein ZapB
Aeromonas
MHMSLEVLEQLESKVQSAVDNISLLKMELDELKEQNSKLQDENHLLRNEHVAWQERLRALLGKMEQMGESI
Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
A4STA4
Q88S38
IOLG_LACPL
Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
Lactiplantibacillus
MAEAHVTKVGIVGIGFIGSDHLHRLTKTVANVDVTAVCDIVPGKAQKALDQQGLTATTYEDYHDLVNDPNVEVVVCTANNEAHYEIVMAALKAGKFTFCEKPLALDAKQCMDIIDSEKKLGRRMLQVGFMRHYAPEYVQMKKMIDDGVIGKPLMMDQRHYNQTQPEEYDSSRSIIETAIHEIDIDHWLVNDDYANIRVFSPKQTRHVQNAKIQDPQIVMIETKSGINIINEVFVRCQYGYDIKCDVIGEEGVLELPTVPQVATRLNAQYSTAILTDWKARFESAYDIEFRDFINHVSQNESPVGPSAWDGYIAAVTADAALKSLAEDGAKQDLDFPSTPAFYTESEKVSE
Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively.
Q88S38
Q28RK1
URED_JANSC
Urease accessory protein UreD
unclassified Jannaschia
MLDAATPTHQRVRGRAMARFTGRRLRDLHQSGSAKVLIPRVFGRAPEVVFLNTAGGITGGDRLDYALHVDDGTCVGTTQTAERAYRSHGPMGRVSTRLTIGQGATLHWVPQEMILFDGVALERDLSVEMAGDAELVMLETLVLGRAAMGEVLRDLHLRDRRRVTRGGKLAMVEAIGLGPDDFASSSPAGLNGAVATASLTLMAQDAEDRLNALRAVLPTDVRSAASAWDGRLTARFLAPQAYPLRRAVARAVEQVTCGALPRVWQI
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Q28RK1
A1ALL1
ATPL1_PELPD
Lipid-binding protein 1
Pelobacter
MNFFTMCVFGAAIGMAIGTLGTAIGQGMAVKSAVEGVARNPGAASKIMTTMMIGLAMIESLAIYALVVCLIILFANPYKDIALKMVETVAK
Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
A1ALL1
B8NI18
IMQA_ASPFN
Imizoquin biosynthesis cluster protein A
Aspergillus subgen. Circumdati
MVDSVFPAPSLVDETFLAPSSSETNDTAMAADGTLAKMNMFQFNSMLKEYSPPRFEDLFQDLDASKAGWEHYRPRLVSEVDLIDAEHYSLFSANTVSPL
Part of the gene cluster that mediates the biosynthesis of imizoquins A to D, tripeptide-derived alkaloids that serve a protective role against oxidative stress that are essential for normal germination . ImqB is a canonical three-module NRPS that assembles the tripeptide backbone of the imizoquins via condensation of Trp, Tyr, and Leu-derived precursors . N-methylation by imqF and phenol oxidation by imqC, followed by cyclization via the FAD-dependent oxidase imqH carry out the three-step transformation of L-tyrosine into tetrahydroisoquinoline . Importantly, this sequence requires the presence of a free amine in the tyrosine moiety, indicating that isoquinoline formation occurs prior to peptide bond formation . The imidazolidin-4-one ring of imizoquins could form following additional oxidation of the methyl-derived bridgehead carbon by imqH . Lastly, O-methylation by imqG and leucine hydroxylation by imqE complete biosynthesis of the imizoquins .
B8NI18
Q9AET7
ASP3_STRGN
Orf3
Streptococcus
MKIQKHKEIYWGELRGASISKTRKDFTYLYGSTIIFHSPDQVYFENKLIASGQTIHEWSSSWNYQGDRQVPSLPLLKRGRSYSLTRDMTSYPSESVFLKLIFFDRYNREVSNHVERSDKMTFTYPEEAYSYKVQLLSAGVESFEFHCLRIEEILEESNG
Part of the accessory SecA2/SecY2 system specifically required to export GspB, a serine-rich repeat cell wall protein encoded upstream in the same operon.
Q9AET7
A8M4B3
ALR_SALAI
Alanine racemase
Salinispora
MWQAEVRVDLDAIRENVSWLRSGSAAELMAVVKGDGYGHGMVPAALAALDGGADWLGVCTLDEALTLRREGITAPILAWLLAPGLPLHEGVAAGIDLGAASVAQLDEMVQAGRTAGRPARLHLKIDTGLSRGGATVSDWPGLLTAAAKAQADGTVEVVGVWSHFVYADAPGHPTTDRQLAVFHEGLDMVEKAGLRPRYRHLANSAATLTRPDAHFDLVRPGLAVYGLSPVAGESFGLRPAMTARARVMLTKQVPAGAGVSYGHTYTTERDSTLAVIPLGYADGVPRSASNSGPVHLGGVRRTISGRVCMDQFVLDCGDDPVAPGDVAVLFGSGRNGEPTADDWAEAVGTINYEIVTRFGSTRVPRSYDGERP
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
A8M4B3
A2CBX2
PANCY_PROM3
Cytidine monophosphate kinase
Prochlorococcus
MGALHRAHGQLIKSVQGFGSLQPAAVLVSVFVNPLQFGPAEDFDSYPRDLEADCELASRSGASALWAPSVDQVFPGGASSQFRIQVPSHLQAHLCGAIRPGHFDGVVTVVARLLALVRPEVLVLGEKDWQQLVILRHLVAQLGLPVRVHGVATVRDDDGLACSSRNRYLMTQQRQQALALPQLLARAARESQDGRAVDLAGLRCAWEQLGLEVEYVETVDAFNLQPLHAGRKLCLLAAAVRCGETRLIDHTFLMSRQPIVAIDGPAGAGKSTVTRAFAERLGLLYLDTGAMYRAVTWLTQQHDVDPHDPVAVKTILENLELELEPSQSGPQKVRINGHDVTEAIRSPEVTSSVSVVAAHGCVRKALTAQQQRMGVRGGLVAEGRDIGTAVFPDAELKVFLTASPAERARRRALDLDNRGFPVPDLAELETQIEERDRMDSTREVAPLRQAEDATELISDGMSIEEVIETLIDLFRVQVPEEVWPTPGS
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.
A2CBX2
Q9DA32
SUN5_MOUSE
Sperm-associated antigen 4-like protein
Mus
MPRTRNIGALCTLPEDTTHSGRPRRGVQRSYISRMAEPAPANMNDPLLLPLRMNTPGLSLVQILLGYMSWLTYLACFLRTQTQQVFLNTCRCKLFCQKVMEKMGLLVLCVFGFWMFSMHLPSKVEVWQDDSINGPLQSLRMYQEKVRHHTGEIQDLRGSMNQLIAKLQKMEAISDEQKMAQKIMKMIQGDYIEKPDFALKSIGASIDFEHTSATYNHDKARSYWNWIRLWNYAQPPDVILEPNVTPGNCWAFASDRGQVTIRLAQKVYLSNITLQHIPKTISLSGSPDTAPKDIVIYGLESLPREEVFLGAFQFQPENVIQMFQLQNLPPRSFAAVKVKISSNWGNPRFTCMYRVRVHGSVTPPKDSHLEPLS
Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.
Q9DA32
P63239
NEC1_MOUSE
Proprotein convertase 1
Mus
MEQRGWTLQCTAFAFFCVWCALNSVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPRRSRRSALHITKRLSDDDRVTWAEQQYEKERSKRSVQKDSALDLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKITDMSGRMQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVNVVEKRPTQKSLNGNLLVPKNSSSSNVEGRRDEQVQGTPSKAMLRLLQSAFSKNALSKQSPKKSPSAKLSIPYESFYEALEKLNKPSKLEGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEEN
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.
P63239
O85735
CSRA_SERMA
Repressor of secondary metabolites
Serratia
MLILTRRVGETLMIGDEVTVTVLGVKGNQVRIGVNAPKEVSVHREEIYQRIQAEKSADDLLIPKQRLVA
Involved in the process of swarming and quorum-sensing signal production; overexpression strongly inhibits swarming motility, pigment and N-acylhomoserine lactone (quorum-sensing signal) production but not swimming motility or swarmer cell differentiation .
O85735
B2IA20
HSLU_XYLF2
Unfoldase HslU
Xylella
MPSKTDFTSSTMTPREIVQELDRHIVGQQAAKRSVAIALRNRWRRMQLPEELRNEVMPKNILMIGPTGVGKTEIARRLATLANAPFVKVEATRFTEVGYVGKDVEQIGRDLVDTAVKMYREQAKVRVRTQAEEYAEERILDALLPRRSVGIGFDADADAIRQEPSAHESETRAKFRRMLRSGELEEREIELDVAVNVSMDIMTPPGMEEMGQQLRQMFSNIGGGKSQKRKLAIKAARPLLIEEEAAKLVNEDEIRAAAIEACEQNGIVFIDEIDKVVKRGDTVGGGDVSREGVQRDLLPLVEGSNVSTKYGTIRTNHILFIASGAFHLTKPSDLIPELQGRFPIRVELDALSKADFIRILTEPKAALTKQYQELLKTEGVSLDFTEDAIDRIAEIAYLVNERQENIGARRLHTVLERLLETLSYESPDRDGESVTVDADYVNAHLGELVKDPDLSRYIL
ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
B2IA20
Q2FLB5
ENO2_METHJ
2-phosphoglycerate dehydratase 2
Methanospirillum
MDTRIKRIIAREILDSRGNPTVEVDITLNNGIRGRAACPSGASTGIHEAVERRDGEKRFGGKGVQGAVQAVMDIISPKLLGRDALEQKSIDSVMIELDGTPNKAKLGANAILTVSMAVARAAANSEDVLLSEYLGPKSTLMPVPCMNIMNGGAHANWQGSDFQEYMIAPVGAPDYPEAVRWGCEVYHSLKSVLKKKGLSTGVGDEGGFAPIVPSNLEPASLIVHAIEEAGYIPGKDIALVLDPASSGFYKDGKYTLKTEKKVLTSEEMTDYYEDMIRTYPIISIEDGLAEDDWEGFAFMTKRLGNTIQIVGDDIFVTNPERIHRGLKEKTANAVLIKLNQIGTVTETIDAIRLAQKAGWGTMVSHRSGETCDSFIADLTVALGCGQLKTGAPCRGERVEKYNQLLRINEFLGDKARYAGRQAFNSA
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Q2FLB5
Q9JJN5
CBPN_MOUSE
Carboxypeptidase N small subunit
Mus
MPDLPSAFLPLLLLSKFVTPVTFRHHRYDDLVRTLYKVHNQCPDITRLYNIGRSVKGRYLYVLEFSDYPGIHEPLEPEVKYVGNMHGNEVLGRELLLQLSEFLCEEFRNRNQRILRLIQDTRIHILPSMNPDGYEVAAAQGPNMSGYLVGRNNANGVDLNRNFPDLNTYFYYNSKNGGPNHHLPLPDNWKSQVEPETRAVIQWIRSLNFVLSANMHGGAVVANYPYDKSLEHRFRGPHRTSNSPTPDDELFQTLAKVYSYAHGWMHQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPRQEELQREWLGNREALIQFLEQVHQGIKGMVLDENSNNLTGAVISVTGINHDVTSGEHGDYFRLLLPGTYSVTAKAPGYDPKTVTVTVGPAGPTVVDFQLKRSSSQVYPVQRAPGRGQGGRAKQPRTSRKKDPATKRHRGPA
Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
Q9JJN5
Q43517
FER1_SOLLC
Ferredoxin I
Solanum subgen. Lycopersicon
MASISGTMISTSFLPRKPAVTSLKAISNVGEALFGLKSGRNGRITCMASYKVKLITPEGPIEFECPDDVYILDQAEEEGHDLPYSCRAGSCSSCAGKVTAGSVDQSDGNFLDEDQEAAGFVLTCVAYPKGDVTIETHKEEELTA
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Q43517
B7IT40
KAD_BACC2
Adenylate monophosphate kinase
Bacillus cereus group
MNLILMGLPGAGKGTQAEQIVAKYNIPHISTGDMFRAAMKAETEMGLQAKSFIDKGALVPDEVTIGIVRERLSQEDCVRGFLLDGFPRTVAQASALEEIMKDLGKKIDYVLNINVDSGLLLKRLTGRRICKECGATYHLEFNPPAKADVCDKCGGELYQRSDDNEETVANRLDVNIKQTKPLLDFYDELGYLKSINGEQDINKVFADIDVLIGGLA
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
B7IT40
Q5M5N0
PYRH_STRT2
Uridine monophosphate kinase
Streptococcus
MAEPKYKRVLIKLSGEALAGEKGVGIDLPTVQAIAKEIAEVADSGIQIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTTMNALVMADSLKQLGVDTRVQTAIDMKSVAEPYIRGRALRHFEKGRIVIFAAGIGSPYFSTDTTAALRAAEIESDAILMAKNGVDGVYNDDPRKNADAVKFDKLTHVEVIKRGLKIIDATASTLSMDNDIDLVVFNMNEPGNIKRVIFGEQIGTTVSNKAELRK
Catalyzes the reversible phosphorylation of UMP to UDP.
Q5M5N0
Q8K9J0
PTGCB_BUCAP
PTS system glucose-specific EIIB component
Buchnera
MFKNVFSSLQKVGKSLMLPVSVLPIAGILLGIGSAHFTLIPEIISQIMAQTGGSIFSNMPLIFAIGVALGFSNNDGVAALAAVVAYSILIQTLSAVELNILNTDANTIKNKNFSDIGILGGIIAGAISAYMFNKFYKIQLPEYLGFFAGKRFVPIISGLFAIFVGLILSLIWPSIGNKIQIFSEWAAYQNPIIAFSLYGLVERALVPFGLHHIWNVPFQMQIGEYKNSIGQIFHGDIARYMAGDTTAGNLSGGFIFKMYGLPGAALAIWHTAKKENRKKIGSIMISAALTAFLTGITEPIEFSFILVAPILYIIHAILAGLSFPLCIFLNMRAGTSFSHGFIDFIVLSGHSHKIFLFPIVGICYGLLYYSIFYFLITTFNLKTPGREENKNTVFFRNNIEIAPYIVEALGGKNNIKNLDACITRLRITVSEISKVNEENLKNLGAAGVVISGSGVQAVFGTRSENIKTAIDEYINNI
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II complex composed of PtsG and Crr is involved in glucose transport.
Q8K9J0
Q5E2G9
ASTD_ALIF1
Succinylglutamic semialdehyde dehydrogenase
Aliivibrio
MTHWIAGDWVLGEGETIQSLSPYNSEVVWKGESATEAQVESAVNAARNAFIEWKKLPFENRQAIVERFAELVKENADSIAEVIAKETGKPFWETKTEAGAMVGKIAISIRAYHERTPYKEREAAGNKIVLRHRPLGVMAVFGPYNFPGHLPNGHIVPALLAGNTVVLKPSEQTPWTSEVIMKLWQKSGLPKGVINLVQGARATGEALANTKGIDGLLFTGSANTGHILHRQFAGDTGKMLALEMGGNNPMVISKAFGDLDATVYTIVQSAFISAGQRCTCARRLYVPEGKQGDALLARLVDVTKNIHVDQPFSETTPFMGPQISIAAAEFILNAQKKLQALGGESLLEARSLGHAFVSPGIIDATNVAELPDEEYFGPLLQVIRYTTLAQAVELANDTRYGLSAGLVSTDDSEWDYFVEHIRSGIVNRNRQLTGASGDAPFGGPGASGNLKPSAYYAADYCAYPMASMEGDACEIPEQLSPGLTL
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
Q5E2G9
Q9CQ37
UBE2T_MOUSE
Ubiquitin-protein ligase T
Mus
MQRASRLKKELHMLAIEPPPGITCWQEKDQVADLRAQILGGANTPYEKGVFTLEVIIPERYPFEPPQVRFLTPIYHPNIDSSGRICLDILKLPPKGAWRPSLNIATVLTSIQLLMAEPNPDDPLMADISSEFKYNKIAFLKKAKQWTEAHARQKQKADEEELGTSSEVGDSEESHSTQKRKARPLGGMEKKFSPDVQRVYPGPS
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
Q9CQ37
B7IWF0
MTNB_BACC2
Methylthioribulose-1-phosphate dehydratase
Bacillus cereus group
MKQLFRQWYDLSEIKKELTTRNWFPATSGNISIKVSHEPLTFLITASGKDKTKTTPDDFLLVDHVGVPVLETELRPSAETILHTHIYNNTNAGCVLHVHTTDNNVITNLYSDAVTLQNQEIIKALDIWEEGATIHIPIIENHAHIPTLGENFRKHIKGDSGAVLIRNHGITVWGRDSFDAKKRLEAYEFLFQFHIKLLSIQGGVSNGANSYS
Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).
B7IWF0
B7NFY3
UBIC_ECOLU
Chorismate pyruvate-lyase
Escherichia
MSHPALTQLRALRYFKEIPALDTQLLDWLLLEDSMTKRFEQQGKTVSVTMIREGFVEQNEIPEELPLLPKESRYWLREILLCADGEPWLAGRTVVPVSTLSGPELALQKLGKTPLGRYLFTSSTLTRDFIEIGRDAGLWGRRSRLRLSGKPLLLTELFLPASPLY
Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway.
B7NFY3
Q02962
PAX2_HUMAN
Paired box protein Pax-2
Homo
MDMHCKADPFSAMHPGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVDKIAEYKRQNPTMFAWEIRDRLLAEGICDNDTVPSVSSINRIIRTKVQQPFHPTPDGAGTGVTAPGHTIVPSTASPPVSSASNDPVGSYSINGILGIPRSNGEKRKRDEVEVYTDPAHIRGGGGLHLVWTLRDVSEGSVPNGDSQSGVDSLRKHLRADTFTQQQLEALDRVFERPSYPDVFQASEHIKSEQGNEYSLPALTPGLDEVKSSLSASTNPELGSNVSGTQTYPVVTGRDMASTTLPGYPPHVPPTGQGSYPTSTLAGMVPGSEFSGNPYSHPQYTAYNEAWRFSNPALLSSPYYYSAAPRGSAPAAAAAAYDRH
Transcription factor that may have a role in kidney cell differentiation . Has a critical role in the development of the urogenital tract, the eyes, and the CNS.
Q02962
P75569
PTG3C_MYCPN
PTS system glucose-specific EIIA component
Mycoplasma
MQIKAQDTGQQKKSCLLSNIRNKWKNRNRGSFRQWVGKLSNGLMIPIAVLPIAGIFLGVGDAIAGNAGDLTGLRYFGLFIKNGGDVVFANLPILFAIAIAITFSQDAGVAGFSAFVFWAAMNGFMSSLILPFDKAGKIITDTSTPIAGFKVLYNKSVPVHAIATTLGLRTLSTSVFGGIIVGALTSVLYKKFYAIRLPDVIGFFSGTRFVPIICFVVAIPVALILLMIWPAVSIGLNAIGTGLGFLGGKGYGANSLIFGYIERSLIPFGVHHAFYAPLWYTSAGGSLQEIVNQQVWIRPDFHLSDNYVARVIGWVDPNNSSMYIIPGALNGQNGSSTGNTMSKDLNGALSAYMSKESTAFLTWKDLVDGLTFKGNFDKMAENGLLDGSNKIWLGLNGSGILGKKLLLSDGNVYTITFKTFANTTPIAWSKGAQAVLPLNASSTIVNNPTALAAATQSNNNTNNIKLYPVNSFRVAVESLNPAQYSQGKFPFMLFGIPAAGVAMILAAPKDRRKEAASIVGSAAFTSFLTGITEPFEFTFLFLAPWLFYGVHAVLAAVSFWLMNILGANVGQTFSGSFIDFILYGALPDGRRWLANSYLVPIIGLFLAAIYFPTFYFLIKHFNLATPGRGGKLITKKEYLASKAAAKAEGVSGVAENFTQTQIEAGILLQAYGGKENIVELGACITKLRVTVKNPELVKEEPIKELGAAGVMRTTPTFFVAVFGTRAAVYKSAMQDIIQGKVNWEALQKVINTDQLAVEPKETTPPKEVMPVVQDEIVILSPVNGTLKSLNQVPDETFKQKLVGEGVAIVPSDGHFKAPGEAGVKTELAFPGGHAYIFDIDGIKVMLHIGIDTVQINAKKQPGEPLEVFDIKTKQGEYTKEKSESVVEVDLKKLSKKYNPITPFVVMKESLENFKLVPIRQRGEIKVGQPIFKLVYKKSQA
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport.
P75569
E7KI83
GEP3_YEASA
Found in mitochondrial proteome protein 38
Saccharomyces
MLNLCHALRGVRQFSCSVIVKVKCASCSIKLQDQDPSKPGYYTKPKSLPDSKLNPDLQDLKYLLFSQDIQLSKQAIQNDPDLKTKRDLLLRVICKRCSNALHHNNYNPEEFPESTLNDILNYVPRGSNVMHIVPFVEFPLHLDPNVLKRNDLETTLVLTKSDQVFKDKNAVSKKVPIFMKQFLKNTLRIDSNKTFAISALKNWNISMFYNYFKNYTYLLGNPNVGKSTLINTLLQKYLGYKVKIDSTGKINSPSEEVMQEAFTNPKNFFKIQAAGVSHIPNLTRSVQAYQVGGKILFDLPGYSTSTSRLRLEEPIDERWLQRLRKTDLFNRKHIKQKTYESMKGTSQGGCYTVGGIFYLVPPKGSINQIVKYIPGPSKTFKNIEKGIDVFNSCNSSSGTHPLSRYCGIKSVICEKSQYKRYAIPPFIGSIEIVLKDIGYILLRTTGRYEFKGLHEIWIPRGIQVGIREPLENLIESGYQRYIETNGKESSCPRDRPIISSLYEMAPDEADTLNAVKKSYLEKTEKDLSARRFVDDDPYDLVQHLRKKKESLLVLPMVRLAVHLVAPISSNAHVNMNVSKLKRKLGTKYIQKRIYRK
Interacts genetically with prohibitins and thus may be involved in the mitochondrial lipid metabolism.
E7KI83
B3E468
RUVB_TRIL1
Holliday junction ATP-dependent DNA helicase RuvB
Trichlorobacter
MERAITPEKRDDDLQFDATLRPRTLQDYIGQEKIRENLKLFIDAAKGRSEALDHVLLYGPPGLGKTTLANIIACEMGVNIKSTSGPVIERPGDLAAILTNLEPHDVLFIDEIHRLSHVVEEILYPAMEDFQLDIIIGQGPSARSIKLDLPRFTLVGATTRAGLLSSPLRDRFGVISRLEFYTHDELAFIVTRSARILGMAIDREGALELARRSRGTPRIANRLLRRVRDYAQVRADGAITLSVVQETLRLLEIDEMGFDQMDRMILLTIIDKFGGGPVGLDTIGAAIGEESDTIEDVYEPFLIQNGFLNRTPRGRVATPAAYQHFGRLTPERPQGSLF
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
B3E468
O30298
BSUHB_ARCFU
Inositol-1-phosphatase
Archaeoglobus
MDERDALRISREIAGEVRKAIASMPLRERVKDVGMGKDGTPTKAADRVAEDAALEILRKERVTVVTEESGVLGEGDVFVALDPLDGTFNATRGIPVYSVSLCFSYSDKLKDAFFGYVYNLATGDEYYADSSGAYRNGERIEVSDAEELYCNAIIYYPDRKFPFKRMRIFGSAATELCFFADGSFDCFLDIRPGKMLRIYDAAAGVFIAEKAGGKVTELDGESLGNKKFDMQERLNIVAANEKLHPKLLELIK
Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P), 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6-phosphate and fructose-6-phosphate. May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.
O30298
Q76LV1
HS90B_BOVIN
Heat shock protein HSP 90-beta
Bos
MPEEVHHGEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDEEKPKIEDVGSDEEDDSGKDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVTAEEPSAAVPDEIPPLEGDEDASRMEEVD
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes, that act as adapters, simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process, properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally, ADP is released from HSP90 which acquires an open conformation for the next cycle. Apart from its chaperone activity, it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. They first alter the steady-state levels of certain transcription factors in response to various physiological cues. Second, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Third, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation. Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery. Main chaperone involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn, activates its own transcription. Involved in the translocation into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) of leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1; the translocation process is mediated by the cargo receptor TMED10.
Q76LV1
Q04L74
RS20_STRP2
30S ribosomal protein S20
Streptococcus
MANIKSAIKRAELNVKQNEKNSAQKSAMRTAIKAFEANPSEELFRAASSAIDKAETKGLIHKNKASRDKARLSAKLAK
Binds directly to 16S ribosomal RNA.
Q04L74
Q74N79
RL5_NANEQ
50S ribosomal protein L5
Nanoarchaeum
MEHPMRKIRIEKVTLNIGVGESGEKLDKAYELLKRLTGQKPVKTKAKVRVEQWHIRPGLPIGVKVTLRGEKAYKILKEKLLPAVDFKIKASSFTDRGFGFGIPEYIMIPGMKYDPELGLIGLEAYVTLERPGYRVERRRIKRSKVGSRHRLNKEEIIKWAQEELGVQII
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Q74N79
Q9PLX1
RL3_CAMJE
50S ribosomal protein L3
Campylobacter
MEYIVEKIGMSRTITNPSIAVTLLRVVNAKVCEVEGGKALVAYPKGKASNKCVAGQQKKYNLSAEYNRFATLEVANTEAGDLDETPLNEAKILKVSFNTKGRGYSGVMKRHNFAGGPASHGSRFHRRHGSIGNREWPGRVQPGMKMAGHYGNTKVTIKNEVVSYDAENKILVVKGAVPGYNGAMGKIRIAK
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Q9PLX1
B8CKR1
ISPG_SHEPW
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Shewanella
MYNESPIIRRKSSRIYVGDVPIGDGAPIAVQSMTNTRTTDVAATVAQIKALENVGADIVRVSVPTMDAAEAFKLIKQQTNVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNEERIRSVVECARDKNIPIRIGVNGGSLEKELMDKYKEPTPEALLESAMRHVDILDRLNFDQFKVSVKASDVFLAVESYRLLAKQIVQPLHLGITEAGGARAGSVKSAVGLGMLLADGIGDTLRISLAADPVEEIKVGFDILKSLRIRSRGINFIACPSCSRQEFDVISTVNELEQRLEDVVTPMDVSIIGCVVNGPGEALISDIGLTGGNRMSGYYKDGVRQKERFDNNNIVDQLEAKIRAKVAMSESRIPAQDVTK
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
B8CKR1
Q5HNH6
SYY_STAEQ
Tyrosyl-tRNA synthetase
Staphylococcus
MANALIEDLKWRGLIYQQTDEEGIEELLNKEQVTLYCGADPTADSLHIGHLLPFLTLRRFQEHGHRPIVLIGGGTGMIGDPSGKSEERVLQTESQVEANVKGLSNQMHRLFEFGSDKGAKLVNNKDWLGQISLISFLRDYGKHVGVNYMLGKDSIQTRLEHGISYTEFTYTILQAIDFGYLNRELNCKIQVGGSDQWGNITSGIELMRRMYGQTEAYGLTIPLVTKSDGKKFGKSESGAVWLDPEKTSPYEFYQFWINQSDEDVIKFLKYFTFLEKEEINRLEQSKNEAPHLREAQKALAENVTKFIHGEAALKDAIRISKALFSGDLKSLSAKELKEGFKDVPQVTLSTKTTNIVEALIETGIASSKRQAREDVNNGAIYINGERQQSVDYELSSKDLIEDEITIIRRGKKKYFMVNYQS
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
Q5HNH6
A1R8A6
HEM1_PAEAT
Glutamyl-tRNA reductase
Paenarthrobacter
MVLFSLVATHADIDLETVAQLSNGSSELASAALTDSSVVSGAVVLATCNRYEVYGETANGADLEAARSALVSQISELSGLNEQLVSRSFATHTGPDVTRHLFAVSAGLDSAVVGEREIAGQVRRALITAQQEGTASSGLVRLFQAASKTAKDVGAQTALGSRGLSIVSVALDLATDLAENDDWTTKKVVVFGTGAYAGATMSLLRERGCTDISVYSSSGRAEGFVATRGGTALDADTLPAAVAAADVMIGCSGSDNRVEAADLARVRANSGKPLIAIDLALTHDFDPAVGELDGVELLTLESVRLAAPQEQAESLSQASAIVNGAATSFESEREARSVDTAIVALRRHTMNVLDAEMEKVRARHGCTAAAEEVEFALRRMVKQLLHIPTVRARELAANGQQDDYVAALEALYGIQVEQPQAAAPASECPVDHEQLRSESA
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
A1R8A6
Q33DR2
DPS1_MOUSE
Trans-prenyltransferase 1
Mus
MAMRWSCWRRGCSWRPTAVGSPRRERPGCVEPLGTRAASDTRAQIPYFSLMKILMSASPTMHSISQFHQRTPAMCSCRQTQSGEKYSDPFKLGWRDLKGLYEDIRKELHISTRELKDMSEYYFDGKGKAFRPIIVVLMARACNIHHNNAREMQASQRSIALVAEMIHTATLVHDDVIDDASSRRGKHTVNKIWGEKKAVLAGDLILSAASVALARIGNTAVVSMLAQVIEDLVRGEFLQLGSKENENERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQMGKPTSADLKLGIATGPVLFACQQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYCHKAVREIRKLRPSTERDALIQLSESVLTRDK
Heterotetrameric enzyme that catalyzes the condensation of farnesyl diphosphate (FPP), which acts as a primer, and isopentenyl diphosphate (IPP) to produce prenyl diphosphates of varying chain lengths and participates in the determination of the side chain of ubiquinone . Supplies nona and decaprenyl diphosphate, the precursors for the side chain of the isoprenoid quinones ubiquinone-9 (Q9)and ubiquinone-10 (Q10) respectively . The enzyme adds isopentenyl diphosphate molecules sequentially to farnesyl diphosphate with trans stereochemistry .
Q33DR2
Q9HTC0
WBPZ_PSEAE
GDP-D-rhamnose:GlcNAc/GalNAc-diphosphate-lipid alpha-1,3-D-rhamnosyltransferase
Pseudomonas
MRVLHFYKTYLSETVGGIEQVIFQLCESSGSWGIDNHVLTLSSDPHPPVVPFGGHVVHRARLDLQLASTGFSLSVFKQFRELAAEADVVNYHFPWPFMDLVHFLTGMNKPSVVTYHSDIIRQRVLLKLYRPLMSRFLHSVDRIVAASPNYFSTSDVLRQYREKTRVITYGLDKDGYPKPATQRLEHWREKLGPRFFLFVGVMRYYKGLHILLDALQGTDYPVVIVGAGPLQAELYAQAAALGLRNVHFLGRVDDEDKVALLQLSYAMVFPSHLRSEAFGISLLEGAMYGKPMISSEIGTGTSYINIHGETGLVVPPSQPAAFRQAMRWLWEHPQQAEEMGRNAEARYRQLFTAEEMGRRWSELYRELLEEKASSRYVKAAR
Non-processive alpha-1,3-D-rhamnosyltransferase . Catalyzes the transfer of one D-rhamnose (D-Rha) residue from donor substrate GDP-D-Rha in alpha-1-3 linkage to both GlcNAc- and GalNAc-diphosphate-lipid acceptor substrates. Is also able to transfer D-mannose (D-Man) to these acceptors at a lower level. Nucleotide sugars GDP-D-Rha, GDP-Fuc, UDP-Gal, UDP-GalNAc, UDP-GlcNAc and CMP-sialic acid cannot act as donor substrates. Only compounds with a diphosphate as the aglycone group can act as acceptor substrates. No activity is detected with compounds containing a diphosphate mimic. Fluorescent undecyl-anthracenyl group-containing compounds, such as GlcNAc-PO(3)-PO(3)-AnthrU and GalNAc-PO(3)-PO(3)-AnthrU, are also good acceptor substrates . Involved in the biosynthesis of the common polysaccharide antigen (CPA), also called A band, which is one of the two major cell surface O-antigens of the P.aeruginosa lipopolysaccharide . Involved in susceptibility to antibiotic colistin .
Q9HTC0
Q5WLQ1
RL24_ALKCK
50S ribosomal protein L24
Alkalihalobacillus
MHVKKGDKVVVITGKDKGKQGTVLEAYPKKSRVLVEGVNMVKKHAKPSQDNPQGGILNQEAPIHSSNVMLVDPKTGERTRVGYKEENGKKVRVAKKSGEIIK
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Q5WLQ1
G3XD30
PILN_PSEAE
Type IV pilus inner membrane component PilN
Pseudomonas
MARINLLPWREELREQRKQQFLVILGGVLVASAALVFLGDQYFTAAIENQNARNDFLRKEIVVLDARIKEISELKSRRQQLLERMKIIQDLQGNRPIIGRVFDQLVRTLPDGVYFTDLKMTGKNIAIAGAAESNNRVSNLMRNMDASEWLTAPTLNEVKAVTQGAVDQANVFQLTVQQTQPGEEDAKAKHGVAQGAKK
Inner membrane component of the type IV (T4S) secretion system that plays a role in surface and host cell adhesion, colonization, biofilm maturation, virulence, and twitching, a form of surface-associated motility. PilN/PilO heterodimers form the foundation of the inner-membrane PilM/PilN/PilO/PilP complex which plays an essential role in the assembly of a functional T4 pilus . In turn, associates with PilM and facilitates PilM functionally relevant structural changes .
G3XD30
Q1EGL0
LGI3_PANTR
Leucine-rich glioma-inactivated protein 3
Pan
MAGLRARGGPGPGLLALSALGFCLMLQVSAKRPPKTPPCPPSCSCTRDTAFCVDSKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLSFPAVSAEPFLYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPAPSAVHCKPMVVDSQLYVVVAQLFGGSYIYHWDPNTTRFTRLQDIDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWHQNGFYSHQALHPWHRDTDLEFVDGEGKPRLIVSSSSQAPVIYQWSRTQKQFVAQGEVTQVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEVQALPSRGSLALQPFLVGGRRYLALGSDFSFTQIYQWDEGRQKFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRHVVVDLSA
May participate in the regulation of neuronal exocytosis.
Q1EGL0
A8F3S3
RSMG_PSELT
16S rRNA 7-methylguanosine methyltransferase
Pseudothermotoga
MNKVAEIFREYGIKIDDSKTEKLDSYIDLLISAPINLTSLRDKEYAIHKHIVDIVFPVKMLTGKLLDVGTGGGIPGLILAILFPINATLVESVRKKVMWLEKILNMLNIGNVNLLCSRAEKLPADKKESFDIVTARAVSELRILLELCAPFCKVGGRLFFYKGPNWKQEYDAAHNAMKTLNVETIEIVSYTLKTGEKRVLLQFQKVGRTPDNYPRETKKILKNPL
Specifically methylates the N7 position of a guanine in 16S rRNA.
A8F3S3
Q8CWZ6
TIG_STRMU
PPIase
Streptococcus
MSTSFENKATNRGVVTFTISQDKIKPALDQAFNKVKKDLTAPGFRKGHMPRTVFNQKFGEEALYEEALNSILPAAYEEAVAELELDVVTQPKVDVKSMEKGKDWEITAEVVTKPEVKLGDYKNLEVSVEESKEVTDAEVDEKIERERNNLAELVLKEDAAVEGDTVVIDFVGSVDGVEFDGGKGDNFSLELGSGQFIPGFEDQLVGKKAGETVKVNVTFPEDYQSADLAGKDATFVTTIHEVKAKEVPELDDELAKDIDEEVETLDELKAKYRKELEATKETAYNDAVEAAAIDLAVANAEIVELPEEMIHDEVQRAMQEFMGNMQRQGISSEMYFQLTGTTEEDLRKQYEADADKRVKTNLVIEAVAKAEGFEATDEEIEKEISDLATEYKMEAEQVRSLLSPDMLKHDIAMKKAVNVITDSAKVK
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Q8CWZ6
Q8ZL58
TAGAD_SALTY
StTGD
Salmonella
MALSANSDAVTYAKAANTRTAAETGDRIEWVKLSLAFLPLATPVSDAKVLTGRQKPLTEVAIIIAEIRSRDGFEGVGFSYSKRAGGQGIYAHAKEIADNLLGEDPNDIDKIYTKLLWAGASVGRSGMAVQAISPIDIALWDMKAKRAGLPLAKLLGAHRDSVQCYNTSGGFLHTPLDQVLKNVVISRENGIGGIKLKVGQPNCAEDIRRLTAVREALGDEFPLMVDANQQWDRETAIRMGRKMEQFNLIWIEEPLDAYDIEGHAQLAAALDTPIATGEMLTSFREHEQLILGNASDFVQPDAPRVGGISPFLKIMDLAAKHGRKLAPHFAMEVHLHLSAAYPLEPWLEHFEWLNPLFNEQLELRDGRMWISDRHGLGFTLSEQARRWTQLTCEFGKRP
Catalyzes the efficient dehydration of both L-talarate (also called L-altrarate) and galactarate to 5-keto-4-deoxy-D-glucarate (5-KDG) . Also catalyzes the epimerization of L-talarate to galactarate; epimerization occurs in competition with dehydration. Is required for the utilization of L-talarate as a carbon source. Also functions in galactarate utilization. Is not active on other acid sugars .
Q8ZL58
Q8N6L1
KTAP2_HUMAN
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2
Homo
MVVGTGTSLALSSLLSLLLFAGMQMYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQAAAPVLTPAKVTGKSKKRN
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity . May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1 .
Q8N6L1
A1B946
CCME_PARDP
Heme chaperone CcmE
Paracoccus
MKSLKKKRRIQILVAAAVALVLAVGLIGYGFRDGINLYRSPSQMAENPPEAGEVFRLGGLVEDGSLVRGASETVTFRVTDGGATVPVRFTGVLPDLFSEGQGMIGTGRMEGETFVASEILAKHDENYMPREVMDSLKEQGVYQEPNS
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
A1B946
A7M969
PSBE_CUSRE
PSII reaction center subunit V
Cuscuta subgen. Monogynella
MSGNTGERSFADIITSIRYWVIHSITIPSLFIAGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITGRFDSLEQLNEFSRSF
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
A7M969
O52377
AROQ_CORGL
Type II DHQase
Corynebacterium
MPGKILLLNGPNLNMLGKREPDIYGHDTLEDVVALATAEAAKHGLEVEALQSNHEGELIDALHNARGTHIGCVINPGGLTHTSVALLDAVKASELPTVEVHISNPHAREEFRHHSYISLAAVSVIAGAGIQGYRFAVDILANLKK
Catalyzes a trans-dehydration via an enolate intermediate.
O52377
A7H2P1
PRMA_CAMJD
Ribosomal protein L11 methyltransferase
Campylobacter
MQKKYYELFFIVEEQYKNLFLGFAFDLGIEAIEEKDNGIYIRSHESLEELSWALEIFAQKLTTTFNLNHKIISNLSLVEKENKDWIQEYKKGIKPILVDNVYIHTTWQEEKKNCINIKINPALAFGSGHHESTHSCVKFLQKFSKSKLRALDLGCGSGILGIIMAKFGCNVEICDTDELAIDSSLENARLNGVDFHKAWCGSIDKANGLYNLIVANIIADVILILEKDIKNHLEDNAILILSGILDKYSTRIKEKFQDLELIDEMQINEWCSFVYKNNKKDK
Methylates ribosomal protein L11.
A7H2P1
Q9SCY0
PGMP_ARATH
Glucose phosphomutase
Arabidopsis
MTSTYTRFDTVFLFSRFAGAKYSPLLPSPSFTLSTSGIHIRTKPNSRFHSIIASSSSSSVVAGTDSIEIKSLPTKPIEGQKTGTSGLRKKVKVFMEDNYLANWIQALFNSLPLEDYKNATLVLGGDGRYFNKEASQIIIKIAAGNGVGQILVGKEGILSTPAVSAVIRKRKANGGFIMSASHNPGGPEYDWGIKFNYSSGQPAPETITDKIYGNTLSISEIKVAEIPDIDLSQVGVTKYGNFSVEVIDPVSDYLELMEDVFDFDLIRGLLSRSDFGFMFDAMHAVTGAYAKPIFVDNLGAKPDSISNGVPLEDFGHGHPDPNLTYAKDLVDVMYRDNGPDFGAASDGDGDRNMVLGNKFFVTPSDSVAIIAANAQEAIPYFRAGPKGLARSMPTSGALDRVAEKLKLPFFEVPTGWKFFGNLMDAGKLSICGEESFGTGSDHIREKDGIWAVLAWLSILAHRNKDTKPGDKLVSVADVVKEYWATYGRNFFSRYDYEECESEGANKMIEYLREILSKSKAGDVYGNYVLQFADDFSYTDPVDGSVASKQGVRFVFTDGSRIIFRLSGTGSAGATVRIYIEQFEPDVSKHDVDAQIALKPLIDLALSVSKLKDFTGREKPTVIT
This enzyme participates in both the breakdown and synthesis of glucose (Probable). Factor that affects seed oil content . Accumulated starch in young embryos may play an important role in providing carbon resources for seed storage lipid biosynthesis in oilseed plants (Probable).
Q9SCY0
C1KYC4
YDJC_LISMC
Carbohydrate deacetylase
Listeria
MKIIFNADDFGISPGAVYGILESYKRGVVKSTTLLANSPAFDLAVEVAKENPGLDIGAHLTLTFGSPVLQGLETLTDDDGRFRRNYTSLENGLADVDMNEVERELTAQIEKILDAGITISHFDTHHSIEPLIYPVQHKLAEKYGVSIRRHSDVSDFGAIKTPDLFATEFYADGVSFETIKKLVQKHIGTNDVVEVMTHPAFIDETLREISSYVEPRIKEVSILTSRELQAYLGQQEVEIISFRDL
Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides.
C1KYC4
Q250M7
RL22_DESHY
50S ribosomal protein L22
Desulfitobacterium
MQQAKAIARYVRISPRKVRQVVDLIRGKNVSDALAILQFTPKGATEPVTKVLQSAVANAEHNYEMDTDALIVKEIYVDEGPTLKRIKPRAMGRADQIRKRTSHITVVVVEKKEG
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Q250M7
C9SEV5
AMPP3_VERA1
Prolidase
Verticillium
MASGDNVDYEAVMVDEFDALNIEVRVSAGPSSSVPGAALSAPRCPGMRALPLKAPVMSTPVPAAAPLPTPPAVDDGPSAVGVGNVPPAVDDVPSAVDDVVIQKETTKYSAKLHAAKVADELKASAGLVFLPGEPSRTYEYSDMGPAFSSNAATSSTSPASTSLTPRKVLYNGRVPSIKDVLAASDVDEVRHMQDLPAFLHAYAHQHDKATVYLLDASQSHPALVDNARVHIDTAALRPAMDEARVTKTAHEIALIREANAVSSAAHRAVMRHIRRFASERQVAALFTAECTVRGAPTQAYAPIAGSGPNAATLHYGANDEPLAGRHVLVLDAGCEVNCYASDVTRTLPLGPTGHFTPEARHIYDLVERMQEACVAAVAPGLLYYSLHLKASAIALRGLLRLGILKGDEKAIWAAGTVAAFFPHGLGHHIGLETHDVTGRDRLLLAAGEREPRAKRDAVSAEMLVGLAAAVATGPPYRGKQMLRPGMVVTVEPGIYFNKDYIEGYFLREDKHRAFIDRDVLARYYPVGGVRIEDCILVTDDGYENLTKAPKGEDMLRIIRGEAQ
Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.
C9SEV5