accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q8VHL0
UT1_MOUSE
Urea transporter, erythrocyte
Mus
MEDSPTMVKVDRGENQILSCRGRRCGFKVLGYVTGDMKEFANWLKDKPVVLQFMDWILRGISQVVFVSNPISGILILVGLLVQNPWWALCGCVGTVVSTLTALLLSQDRSAIAAGLQGYNATLVGILMAVFSNKGDYFWWLIFPVSAMSMTCPVFSSALSSVLSKWDLPVFTLPFNMALSMYLSATGHYNTFFPSKLFTPVSSVPNITWSELSALELLKSLPVGVGQIYGCDNPWTGGIFLCAILLSSPLMCLHAAIGSLLGVIAGLSLAAPFEDIYFGLWGFNSSLACIAIGGMFMALTWQTHLLALACALFTAYFGACMAHLMAVVHLPACTWSFCLATLLFLLLTTKNPNIYRMPLSKVTYSEENRIFYLQNKKRMVESPL
Mediates the transport of urea driven by a concentration gradient across the cell membranes of erythrocytes and the renal inner medullary collecting duct which is critical to the urinary concentrating mechanism . Facilitates water transport in erythrocytes .
Q8VHL0
Q7VC41
TPIS_PROMA
Triose-phosphate isomerase
Prochlorococcus
MRKTVIAGNWKMHMTCSSAKEYIDKFIPFSKEFPSDRHVVIAPPFTAISTLASLLQGTNIQLSSQNVHWEDTGAFTAEISPSMLLEHDVRYAIVGHSEPRKYFSESDEQINLRARSAQSNGLIPIVCVGESIEQRERGEAERVIRRQVEQGLEQTDLTKLVIAYEPIWAIGTGKTCESNEANRICGLIREWAGFSDLIIQYGGSVKPANIDEIMSMSDIDGVLVGGASLDPENFARIANYQSI
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q7VC41
Q8U4A5
VATB_PYRFU
V-ATPase subunit B
Pyrococcus
MAKEYSTISRIYGPLMIVEGVKGVAYGEVVEIETEWGEKRKGQVLDARENLAIVQVFEGTRDLDIKTTRVRFTGETLKVPVSMDMLGRIFNGIGKPIDGGPEIIPEDRRDVHGAPLNPVARAYPRDFIQTGISAIDGMNTLVRGQKLPIFSGSGLPHNKLAAQIARQAKVLGEEESFAVVFAAMGITYEEANFFKKSFEETGAIERAVLFLNLADDPAIERIITPRMALTVAEYLAFDYDMHVLVILTDMTNYCEALREISAAREEVPGRRGYPGYMYTDLATIYERAGRVRGKKGSITQMPILTMPDDDITHPIPDLTGYITEGQIVLSRDLHRRGIYPPIDVLPSLSRLMKDGIGKGRTREDHPQLAQQLYAAYAEGRSLRDLVAVVGEEALSETDKKYLEFADRFEREFVAQGYDEDRSIEETLDLGWELLAILPETELKRVKKEMIMKYHPKYRGRSS
Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.
Q8U4A5
Q9VZI3
UN112_DROME
Fermitin-1
Sophophora
MIHVGENTWNLRILITDLQVEKTLRVKGDQHIGGVMLNLVDPELPKDWSDHALWWPAKNIWLTRTRSTLDQAGVQSDSFLHFTPMHKTLRVQMPDLRYLDYRVNFSAKTFGAVVSLCKDLDIRYPEELSFCKPLEPEHLKKNFSKLPQRKIPVAEANGIAYVQPALDTNSFVPITGAYNGSNGSLDRSHNGNLLCAPASPYTRRAATAPGTPISSPTGTWKHNSTGYASYDSNSSFGDLQENLAMSPRSPSPDVRARLVRPKSRVEKARLNVGWLDSSLSIMEQGVREYDTLCLRFKYFTFFDLNPKYDQVRINQLYEQAKWSILNEELEPTEEETLMFAALQFQVNHQTDLHPPGIDSGIDTSSQETGGEDDIDSALNELQITLEGPGGGKDQGNITRIPELSDYLKFLKPQRFTLKGYKRYFFTYRDLHLHLYKSQDESRRGAPTISINLKGCEVTPDVNLAQGKFAIRLEVPSEIRNGPNSEVWVRCDNEEQYAKWMAACRLAAKGRSLADSSYDSEVSSIRSLLQMQKPAQGAPLTVNPRSVEPMDYLSPKMMRKLSSKAVQRILEAHANVRQLSLMDAKMKYIQAWQSLPDFGVTLFIIKFDGHKKEELLGVANNRIMRMDLNTGDHIKTWRYNTMKAWNVNWGIKCMMIQLQDENIVFSVQSADCKVVHEFIGGYIFMSMRSKENNQTLNEEMFHKLTGGWS
Probably involved in cell adhesion.
Q9VZI3
Q9LKN0
CHMO_ATRHO
Choline monooxygenase, chloroplastic
Atriplex
MAASATTMLLKYPTTVCGIPNSSANNSTDPSNNIVQIPQTTTTNSPLLKFRTPNKPVNAVAAPAFPSVTTTTTTTPSSIQSLVKDFDPLVPAEDALTPPSSWYTEPAFYAHELDRIFYKGWQVAGYSDQVKEANQYFTGTLGNVEYLVCRDGEGKVHAFHNVCTHRASILACGSGKKSCFVCPYHGWVYGMNGSLTKASKATPEQSLNPDELGLVPLKVAVWGPFILISLDRSSREVGDVGSEWLGSCAEDVKAHAFDPNLQFINRSEFPIESNWKIFSDNYLDSSYHVPYAHKYYATELDFDTYQTDMVGNVTIQRVAGTSNNGFNRLGTQAFYAFAYPNFAVERYGPWMTTMHIVPLGPRKCKLVVDYYIEKSKLDDKDYIEKGIAINDNVQKEDVVLCESVQKGLETPAYRSGRYVMPIEKGIHHFHCWLHQVLK
Catalyzes the first step of the osmoprotectant glycine betaine synthesis.
Q9LKN0
Q4JAI6
PCNA1_SULAC
Proliferating cell nuclear antigen homolog 1
Sulfolobus
MRIVYDDVRDLKNIVETLTKFIDEGLFEIGQDGIRLVAVDKAHVSLINIELYKELFKEYEVEDEFKFGFNSQYLAKILSIAKRKEEISIESDSPERVKITLGGALNRVFIINNIQVSPPEVPEVNLEFEVKASLSSKAFKTTINEISAVTDTVDIIAVEDKVILKGEGKEGSQIENEFSKDTGAISDMEFKNEAKSPYDVNYLSDILSLTNLSDYTRLAFSTEKPLELEFNMEGGGKVTYLLAPKLS
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
Q4JAI6
A9WKM8
METXA_CHLAA
Homoserine transacetylase
Chloroflexus
MEAIVQAPTPEGVGIVRTQRMHWTTPLTLTSGATLGPITLAYETYGELAPDRSNAILILHALSGDAHAAGFHSPTDRKPGWWDAMIGPGRPFDTNRYFVICSNVIGGCRGSTGPSSPHPSDGRPYGSRFPLITIEDMVHAQQRLIDALGIDTLLAVAGGSMGGFQALAWTVEYPQRVRGAILLATSARSSPQTVAWNYIGRRAIMADPRWRGGDYYDSDAPRDGLAVARMLGHITYLCEEKLEQRFGRRVDGDALDLGPRFAIEHYLEHQAARFNDRFDANSYLVITRAMDNWDLTARYGSLTAAFDLTRARFLALAYSSDWLYPPAETYQMAAAAQAAGRSFTTHLITTDAGHDAFLTDVAAQSELIRDFLNRLMTE
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
A9WKM8
A1TVP2
1A1D_ACIAC
1-aminocyclopropane-1-carboxylate deaminase
Acidovorax
MNLQKFPRHALTFGPTPIHPLKRLSAHLGGKVELYAKREDCNSGLAFGGNKTRKLEYLIPEAIEGGYDTLVSIGGIQSNQTRQVAAVAAHLGMKCVLVQENWVNYSDAVYDRVGNIEMSRIMGADVRLDAAGFDIGIRPSWEQAMEDVRRAGGKPFPIPAGCSEHPRGGLGFVAFAEEVRQQEEELGFQFDYIVVCSVTGSTQAGMVVGFAADGRADRVIGIDASAKPEQTREQILRIARNTAELVELGREITDADVVLDTRYGGPEYGLPNEGTLEAIRLCARQEGMLTDPVYEGKSMHGMIDMVRNGEFPAGSRVLYAHLGGVPALNAYSFLFRNG
Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source.
A1TVP2
Q9CWH1
ZBT8A_MOUSE
Zinc finger and BTB domain-containing protein 8A
Mus
MEISSHQSYLLQQLNEQRRQDVFCDCSILVEGKVFKAHRNVLFASSGYFKMLLSQNSRETSQPTTATFQTFSPDTFTVILDFVYSGKLSLTGQNVIEVMSAASFLQMTDVISVCKTFIKSSLDISEKEKDRYFSLSDKDTGSNGVERPPFYSSSWQEEGGSPHSHVSPDPGKPWNKYGYPPASQRSPQRPLAKHEQRKEPSKKAKHVRLPQPSEVVHFKPGKGEAQTDSGNHVSQSEEQVPVDAEVDPAPAGFQYSQGPDGIARSFPDDLTRLRFKCPFCTHVVKRKADLKRHLRCHTGERPYPCQACGKRFSRLDHLSSHFRTIHQACKLICRKCKRHVTDLTGQVVQEGTRRYRLCNECLADVGMESLPADLEAEQHRTAPADGDKDCRWHLSEEENRSYVEIVEDGSADLVIQQVDDSEEEEEKEIKPNIR
May be involved in transcriptional regulation.
Q9CWH1
Q63DG7
XPT_BACCZ
Xanthine phosphoribosyltransferase
Bacillus cereus group
MKVLQEKILNEGKVLSGDVLKVDAFLNHQIDPVLMQEIGKEFAKRFKEENITKIVTIESSGIAPAVMAALELGVKVIFARKRKSLTLQDNMYVASVYSFTKQETNEISLSRNHIDESDRVLIIDDFLANGQAALGLMSLVEQAGASIAGIGIVIEKAFQDGGKKLREQGIRVESLAEIASLDNNAVTFVQQETAEVK
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Q63DG7
Q3MFR5
CLPP1_TRIV2
Endopeptidase Clp 1
Trichormus
MTIPIVIEQSGRGERAFDIYSRLLRERIIFLGQQVDSNLANLIVAQLLFLDAEDPEKDIYLYINSPGGSVTAGMGIFDTMKHIRPDVCTICTGLAASMGAFLLSAGTKGKRMSLPHSRIMIHQPLGGAQGQATDIEIQAREILYHKRRLNDYLAEHTGQPIERIAEDTERDFFMSPDEARDYGLIDQVIDRHAAGSRPVAMVNQ
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q3MFR5
Q1IGC6
METXS_PSEE4
Homoserine transsuccinylase
Pseudomonas
MSTVLPEDSVGLVTPQIARFDEPLALACGRSLAAYELIYETYGELNASASNAVLICHALSGHHHAAGYHAATDRKPGWWDSCIGPGKPIDTNRFFVVSLNNLGGCNGSTGPSSVNPATGKPYGADFPVLTVEDWVHSQARLADRLGIQTWAAIVGGSLGGMQALQWTITYPDRVRHCVDIASAPKLSAQNIAFNEVARQAILTDPEFHGGSFQDQGVTPKRGLMLARMVGHITYLSDDSMGEKFGRELKSDKLNYDFHSVEFQVESYLRYQGEEFSGRFDANTYLLMTKALDYYDPAAAHGGDLAATLAHVTADYCIMSFTTDWRFSPARSREIVDALMAARKNVCYLDIDSPYGHDAFLIPTPRYMQGFANYMNRIVI
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
Q1IGC6
Q8TSY1
RNFE_METAC
Rnf electron transport complex subunit E
Methanosarcina
MYPHRRADMNPISEFIRGITKDNPTFGLVLGLCPTLAVTTSVENGIGMAMGTLFVLVGSNMMVSAIRKGIPGTVRLPVEIIVIATFVTIVDMVMEAFTPDLYTSLGVFIPLIVVNCIVIGRAEAYALKNGVFYSIIDALGEGTGFLLVLILIGGIRELLGTGIIDPFGMTLINLSGVINPAMFMTMSPGAFLTIAVLMTIVNYRRQQKAAKGG
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Catalyzes Na(+) transport, most probably coupled to electron transfer from reduced ferredoxin to methanophenazine and heterodisulfide reductase. Involved in heterodisulfide reduction during methanogenesis from acetate.
Q8TSY1
Q9UPW5
CBPC1_HUMAN
Protein deglutamylase CCP1
Homo
MSKLKVIPEKSLTNNSRIVGLLAQLEKINAEPSESDTARYVTSKILHLAQSQEKTRREMTAKGSTGMEILLSTLENTKDLQTTLNILSILVELVSAGGGRRVSFLVTKGGSQILLQLLMNASKESPPHEDLMVQIHSILAKIGPKDKKFGVKARINGALNITLNLVKQNLQNHRLVLPCLQLLRVYSANSVNSVSLGKNGVVELMFKIIGPFSKKNSSLIKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPVIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDVEAENETENEDDLDQNFKNDDIETDINKLKPQQEPGRTIEDLKMYEHLFPELVDDFQDYDLISKEPKPFVFEGKVRGPIVVPTAGEETSGNSGNLRKVVMKENISSKGDEGEKKSTFMDLAKEDIKDNDRTLQQQPGDQNRTISSVHGLNNDIVKALDRITLQNIPSQTAPGFTAEMKKDCSLPLTVLTCAKACPHMATCGNVLFEGRTVQLGKLCCTGVETEDDEDTESNSSVEQASVEVPDGPTLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQSDIIDRVVYDLDNPNYTIPEEGDILKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTITAMPESNYYEHICHFRNRPYVFLSARVHPGETNASWVMKGTLEYLMSNNPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPSPDLHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNDNATSCDVVEDTGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYNLPSSLLDFENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDIELAENVGDYEPSAQEEVLSDSELSRTYLP
Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins . Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin . Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate . Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK . Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis .
Q9UPW5
Q8VEB3
MACIR_MOUSE
Macrophage immunometabolism regulator
Mus
MEVDINGDSRSTLTTLPLPVAEGSSPGKAEAEKPRCSSTPCSPMRRTVSGYQILHMDSNYLVGFTTGEELLKLAQKCTGGEDSKGEAMPALRAKQLDTGLARSSRLYKTRSRYYQPYEIPAVNGRRRRRMPSSGDKCTKPLPYEPYKALHGPLPLCLLKGKRAHSKSLDYLNLDKMNIKEPADTEVLQYQLQHLTLRGDRVFARNNT
Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells.
Q8VEB3
P93655
LONM1_ARATH
Lon protease homolog 1, mitochondrial
Arabidopsis
MLKLFTSSASRVHHLTPVSRVVGSSPVESPLFKALSQITGWNRRSTSLGHRAFFCSEPTNGEAAAEAETKAVESDSEVSDSKSSSAIVPTNPRPEDCLTVLALPVPHRPLFPGFYMPIYVKDPKVLAALQESRRRQAPYAGAFLLKDDPSADSSSSTDAEKNINELKGKELLNRLHEVGTLAQISSIQGDQVILVGHRRLRIKEMVSEEPLTVKVDHLKDNPFDMDDDVVKATSFEVISTLRDVLKTSSLWRDHVQTYTQHIGDFTYPRLADFGAAICGANRHQAQEVLEELDVHKRLRLTLELMKKEMEISKIQETIAKAIEEKISGEQRRYLLNEQLKAIKKELGVETDDKSALSAKFKERIEPNKEKIPAHVLQVIEEELTKLQLLEASSSEFNVTRNYLDWLTILPWGNYSNENFDVARAQTILDEDHYGLSDVKERILEFIAVGRLRGTSQGKIICLSGPPGVGKTSIGRSIARALNRKFFRFSVGGLADVAEIKGHRRTYVGAMPGKMVQCLKSVGTANPLVLIDEIDKLGRGHAGDPASALLELLDPEQNANFLDHYLDVTIDLSKVLFVCTANVIDMIPNPLLDRMEVISIAGYITDEKVHIARDYLEKTARGDCGVKPEQVEVSDAALLSLIENYCREAGVRNLQKQIEKIYRKIALKLVREGAVPEEPAVASDPEEAEIVADVGESIENHTVEENTVSSAEEPKEEAQTEKIAIETVMIDESNLADYVGKPVFHAEKLYEQTPVGVVMGLAWTSMGGSTLYIETTVVEEGEGKGGLNITGQLGDVMKESAQIAHTVARKIMLEKEPENQFFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLATKKPVRKDLAMTGEVTLTGRILPIGGVKEKTIAARRSQIKTIIFPEANRRDFDELAENVKEGLNVHFVDDYGKIFELAFGYDKQED
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
P93655
Q9B5Q1
CYB_SYLGR
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Sylvicapra
MTNIRKTHPLLKIVNNAFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTADTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYAYTETWNIGVILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFIFPFIIAALAMVHLLFLHETGSNNPTGISSDADKIPFHPYYTIKDILGVLLLILALMTLVLFSPDLLGDPDNYPPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILILMPLLHTSKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLLILVLMPTASTIENNLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q9B5Q1
Q8L9K1
ERF99_ARATH
Ethylene-responsive element-binding factor 13
Arabidopsis
MSSSDSVNNGVNSRMYFRNPSFSNVILNDNWSDLPLSVDDSQDMAIYNTLRDAVSSGWTPSVPPVTSPAEENKPPATKASGSHAPRQKGMQYRGVRRRPWGKFAAEIRDPKKNGARVWLGTYETPEDAAVAYDRAAFQLRGSKAKLNFPHLIGSCKYEPVRIRPRRRSPEPSVSDQLTSEQKRESHVDDGESSLVVPELDFTVDQFYFDGSLLMDQSECSYSDNRI
Acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. Involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.
Q8L9K1
Q9ZT17
AGP3_ARATH
Classical arabinogalactan protein 3
Arabidopsis
MALKTLQALIFLGLFAASCLAQAPAPAPITFLPPVESPSPVVTPTAEPPAPVASPPIPANEPTPVPTTPPTVSPPTTSPTTSPVASPPKPYALAPGPSGPTPAPAPAPRADGPVADSALTNKAFLVSTVIAGALYAVLA
Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.
Q9ZT17
C1DQA8
SECA_AZOVD
Protein translocase subunit SecA
Azotobacter
MFAPLLRVLFGSKNDREVKRMRRAVRAINALEEQMVALTDEQLRAKTEEFRGRLGKGETLDQLLPEAFAVAREAGKRVMGMRHFDVQLIGGMVLHEGKIAEMRTGEGKTLVATLAVYLNALAGKGVHVVTVNDYLARRDANWMRPLYEFLGLSVGVVTPFQPPEEKRAAYAADITYGTNNEFGFDYLRDNMAFSLEDKFQRELNYAVIDEVDSILIDEARTPLIISGQAEDSSQLYLQINALIPRLKRHIEEEEGVVTQEGHYVVDEKTRQIELNEQGHQFIEELLASAGLLPEGDNLYSAHNLQLLTHVYAGLRAHVLFHRNVEYIVQGNQVLLIDEHTGRTMQGRRLSEGLHQAIEAKEGLPIQAESQTLASTTFQNYFRLYHKLAGMTGTADTEAFEFRQIYGLDVVVIPTHRPIARKDFNDLVYLTQEEKYAAIIGDIKECQTQGRPVLVGTASIESSEYVSQLLKKEGIAHQVLNAKYHEKEAEIIAQAGRPGAVTIATNMAGRGTDILLGGNWEVEVAALENPTDEPVAQIKADWQKRHQQVIEAGGLHVIASERHESRRIDNQLRGRAGRQGDPGSSRFYLSLEDNLMRIFASDRVKNFMKALGMQAGEAIEHRMVTNAIEKAQRKVEGRNFDMRKQLLEFDDVANEQRKVIYHMRNSLLESEDIGETIAEFRREVLGAAIGQHIPPQSLPEQWDVAGLEAVLQSDFGVQLPLQQWLDEDDRLHEEALRERILEALLVAYREKEEIAGTEALRTFEKQILLRVLDDLWKDHLLTMDHLRHGIHLRGYAQKNPKQEYKRESFELFQSLLESIKRDAIRVLSHVQVRREDPAEEEERLRREAEALARRMQFQHAAASALAPQAEEDDLEVVEEVPLPGTAPVRPEPKIGRNEPCPCGSGKKYKHCHGQLN
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
C1DQA8
P53591
SUCD_COXBU
Succinyl-CoA synthetase subunit alpha
Coxiella
MSILIDKETRVLCQGFTGKQGTFHSEQAIEYGTQMVGGVTPGKGGQSHLGLPIFNSVHEAVEETSADATMIFVPAPFCKDSIIEAVDAGVRLVVCITEGIPVLDMLEVKAYLRQHPDVRMIGPNCPGVITPGECKIGIMPGHIHQRGKVGIVSRSGTLTYEAVNQTTQMGFGQSTCVGIGGDPIPGTSFIDVLEMFEKDSQTQAIVMVGEIGGTAEEEAAEFIQSNVKKPVISYIAGVTAPPGKRMGHAGAIIAGGKGTAADKYAALEAAGVFVVKSPAEIGKGVAEATGWSTH
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
P53591
P0AA83
CODB_ECOL6
Cytosine permease
Escherichia
MSQDNNFSQGPVPQSARKGVLALTFVMLGLTFFSASMWTGGTLGTGLSYHDFFLAVLIGNLLLGIYTSFLGYIGAKTGLTTHLLARFSFGVKGSWLPSLLLGGTQVGWFGVGVAMFAIPVGKATGLDINLLIAVSGLLMTVTVFFGISALTVLSVIAVPAIACLGGYSVWLAVNGMGGLDALKAVVPAQPLDFNVALALVVGSFISAGTLTADFVRFGRNAKLAVLVAMVAFFLGNSLMFIFGAAGAAALGMADISDVMIAQGLLLPAIVVLGLNIWTTNDNALYASGLGFANITGMSSKTLSVINGIIGTVCALWLYNNFVGWLTFLSAAIPPVGGVIIADYLMNRRRYEHFATTRMMSVNWVAILAVALGIAAGHWLPGIVPVNAVLGGALSYLILNPILNRKTTAAMTHVEANSVE
Required for cytosine transport into the cell.
P0AA83
C1DCA5
NUOC_LARHH
NDH-1 subunit C
Laribacter
MASSLDALKARVESLLGDHLESATIDRGELTIVCSASSIAVSCQLLRDQAGFDQCIDLCGMDYSTYRDGLHDRPRFAVVLHLMSVQNNQRLRVRFFAPDDDFPVVPSLIDVWASVNWYEREAFDMYGIVFEGHPDLRRILTDYGFVGHPFRKDFPVSGHVEMRYDPTEGRVIYQPVTIEPREITPRIIREENYGG
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
C1DCA5
Q2NUV8
LIPA_SODGM
Sulfur insertion protein LipA
Sodalis
MSKPIQMERGVKYRDADKMALIPIKTVAVERQEILRKPSWMKIKLPADSTRIQGIKVAMRKNGLHSVCEEASCPNLAECFNHGTATFMILGAICTRRCPFCDVAHGRPVTPDANEPEKLAQTIADMGLRYVVVTSVDRDDLRDGGAQHFADCISAIRAKNPNIRIETLVPDFRGRMDRALEIINAAPPDVFNHNLENVPRLYRQVRPGADYHWSLKLLENFKVANPQLPTKSGLMVGLGETNAEIVDVMRDLCRHGVTMLTLGQYLQPSRHHLPVKRYVSPQEFDEMKQEALAMGFTHAACGPFVRSSYHADLQAKGIEVK
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Q2NUV8
Q0AUC8
ATPL_SYNWW
Lipid-binding protein
Syntrophomonas
MGVALGAGLAVSIAGIGGGIGMGIAGGKAFEAIARQPEVGGDVRTLLFITLAFIETLTIYGLLIAFMLVGKA
Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Q0AUC8
B5Y1T9
SECA_KLEP3
Protein translocase subunit SecA
Klebsiella
MLIKMLTKVFGSRNDRTLRRMRKVVNIINGMEPAMEKLSDDELKAKTAEFRARLEKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMSVGINMSGLPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYRKVNKIIPHLIRQEKEDSDTFTGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMEEGESLYSPTNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDMADLVYMTEAEKIQAIIEDIKTRTAAGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHASEADIVAQAGYPAAVTIATNMAGRGTDIMLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSETINSIREDVFKATIDAHIPPQSLEEMWDIEGLQERLKNDFDLELPIKEWLDKEPELHEETLRERILQSAVETYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEQQRREEAERLAQMQQLSHQSDDEAAAEDLAAQTGERKVGRNDPCPCGSGKKYKQCHGRLS
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
B5Y1T9
Q6FYZ6
GCSH_BARQU
Glycine cleavage system H protein
Bartonella
MSQIYFTQDHEWLSVEGQVVTVGITNYAQEQLGDLVFVDLPQSGTKLSKGDAAAVVESVKAASDVYAPLDGEVVEINEALANSPELVNQKAEKEGWLWKMTVQDETQLEGLLDEAAYKTLIG
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
Q6FYZ6
A6KYS6
LUXS_PHOV8
Autoinducer-2 production protein LuxS
Phocaeicola
MKTIPSFTIDHIRLLRGIYVSRKDEVGGETVTTFDIRMKEPNREPALGQGALHTIEHLAATYLRNHPIWSDKIVYWGPMGCLTGNYLLMKGDLKSEDIVELMQETFRFVADFEGEVPGAAPKDCGNYLLHDLPMAKWESAKYLHEVLEHMTKDNLYYPTKE
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
A6KYS6
A4SVI8
KAD_POLAQ
Adenylate monophosphate kinase
Polynucleobacter
MRLILLGAPGAGKGTQAQFICEKFAIPQISTGDMLRAAVKAGTEFGVAAKKIMDAGGLVSDDIIIGLVKDRLTQPDCSKGYLFDGFPRTIPQAQAMKDAGVPIDYVLEIDVPFDAIIDRMGGRRVHPASGRTYHIKYNPPKVEGKDDVTGDALIQRDDDKEETVRKRLQVYDDQTRPLVEYYSSWAAQANAADKVKAPAYRKVSGTGSVEDITTSIFAQLK
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
A4SVI8
A7FUX9
MSRA_CLOB1
Peptide-methionine (S)-S-oxide reductase
Clostridium
MKEIVLAGGCFWGVEEYMSRIEGIVETKVGYANGIKENPSYEEVCSGVTGHAEACYIKYDESIISLEELLNKFWSIIDPTVLNKQGNDRGTQYRTGIFYLDEKDLNVIIKSKYQEQKNYRKPIVTEVEPLKCFYEAEEYHQKYLKKNPGGYCHIHLD
Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
A7FUX9
Q6G1A4
PURA_BARQU
IMP--aspartate ligase
Bartonella
MANVVVVGTQWGDEGKGKIVDWLSERADIVVRYQGGHNAGHTLVVNGVNYKLSLLPSGLVRGKLSIIGNGVVVDPHHFVAELKKLRDQGVKITPEILRIAENAPLILSLHRDLDATRESGLSGLKIGTTKRGIGPAYEDKVGRRAIRVMDLAETNTLMAKIERLLAHHNALRRGMGVAEINSQALYDELMQVADEILPFMDCTWRLLDESYQVGKHVLFEGAQGALLDNDFGTYPYVTSSNTVAGQACTGSGIGPGVIHYVLGIAKAYTTRVGEGPFPTEQINDIGEFLGMRGKEFGVVTGRKRRCGWFDAVLVRQMVTICGVQGIALTKLDVLDGLDEIKICIGYELDGKRINYLPSSMGAQARVMPVYETLEGWKEATAHALSWEDLPPQAVKYIRYIEKLINARVALLSTSPEREDTILVTDPFAD
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q6G1A4
Q5X4B2
MUTS_LEGPA
DNA mismatch repair protein MutS
Legionella
MSSSHTPMMQQYLRIKTDYPDMLLFYRMGDFYELFFDDAKRASQLLDLTLTHRGQSADKPIPMAGVPYHAVENYLARLLKKGESVAICEQIGDPATSKGPVERQVTRIITPGTVTDEALLDARKDNILLAIHTQKQKIGIAWVDLGGGRFHLQELTEEHQLNAELVRLQPAELLCKESTPLPSFCSNFAVKFRPGWEFDASNAHKLLCEQFSVTDLSAFGEQNYPTALIAAGALLAYLKTTQKQSLPHLTTLTLEQSEDYLQLDASTQKHLELFENIHGGGEHCLLSILDKTACAMGSRLLKRWLGKPLKQHAIIQTRQQAIKEIIFLQQDVSLHQLIKQCADVERIVSRIALKSARPRDLVSLLQTLTLLPAIHDELQENKSLLINEIKKEISPLPLLQQLLETAIIDNPPMLIRDGGVIAPGFDEELDELRNLSSNAHETLVKLEQEEKNRTGLSTLKLGYNSVQGFYIELSKAQAQNAPPHFHRKQTLKNVERYITPELKLFEDKVLSAQSKALAREKWLYDNLLEEIQQYIPELSDLAKSLAQLDVLVTLAERAQSLNWNCPNLVPESGIMIQAGRHPVIEPLLQERFIANDLELKPNQNMLLITGPNMGGKSTYMRQTALIVLLSHIGSFVPADEVTLGPLDRIFTRIGASDDLSSGRSTFMVEMTETAQILRQATSQSLVLIDEIGRGTSTYDGMALAYASCAFLASTIKAYTLFSTHYLELTELPKEFSCIRNVHLQASIKTGQIVFLYRVEEGCANRSYGLEVAELAGIPKEVLKLAHEHLNQIQDTQSILVQTQIIKPPTSPVLTELKKIDPDRLTAKEALDLIYKLKHLECAESIN
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
Q5X4B2
Q3YUK4
DSBD_SHISS
Protein-disulfide reductase
Shigella
MAQRIFTLILLLCSTSVFAGLFDAPGRSHFVPADQAFAFDFQQNQHDLNLTWQIKDGYYLYRKQIRITPEHAKIADVQLPQGVWHEDEFYGKSEIYRDRLTLPVTINQASAGATLTVTYQGCADAGFCYPPETKTVPLSEVVANNAASQPVSVPQQEQHTAQLPFSALWALLIGIGIAFTPCVLPMYPLISGIVLGGKQRLSTARALLLTFIYVQGMALTYTALGLVVAAAGLQFQAALQHPYVLIGLAIVFTLLAMSMFGLFTLQLPSSLQTHLTLMSNRQQGGSPGGVFVMGAIAGLICSPCTTAPLSAILLYIAQSGNMWLGGGMLYLYALGMGLPLMLITVFGNRLLPKSGPWMEQVKTAFGFVILALPIFLLERVIGDIWGLRLWSALGVAFFGWAFITSLQAKRGWMRVVQIILLAAALVSVRPLQDWAFGATHTAQTQTHLNFTQIKTVDELNQALVEAKGKPVMLDLYADWCVACKKFEKYTFSDPQVQKALADTVLLQANVTANDAQDVALLKHLNVLGLPTILFFDGQGQEHPQARVTGFMDAETFSAHLRDRQP
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Q3YUK4
Q5XC65
GLYA_STRP6
Serine hydroxymethyltransferase
Streptococcus
MIFDKGNVEDFDKELWDAIHAEEERQEHHIELIASENMVSKAVMAAQGSVLTNKYAEGYPGNRYYGGTECVDIVETLAIERAKKLFGAAFANVQAHSGSQANAAAYMALIEAGDTVLGMDLAAGGHLTHGSPVNFSGKTYHFVGYSVDADTEMLNYEAILEQAKAVQPKLIVAGASAYSRSIDFEKFRAIADHVGAYLMVDMAHIAGLVAAGVHPSPVPYAHIVTSTTHKTLRGPRGGLILTNDEALAKKINSAVFPGLQGGPLEHVIAAKAVAFKEALDPAFKDYAQAIIDNTAAMAAVFAQDDRFRLISGGTDNHVFLVDVTKVIANGKLAQILLDEVNITLNKNAIPFETLSPFKTSGIRIGCAAITSRGMGVKESQTIAHLIIKALVNHNQTVILEEVRQEVRQLTDAFPLYKK
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
Q5XC65
B8G5S6
RUVB_CHLAD
Holliday junction ATP-dependent DNA helicase RuvB
Chloroflexus
MSAERLVNPHSDSDDQQVEKSLRPRTLSEFIGQEKVVEQLRIAIAAARGRNEALDHTLFYGPPGLGKTSLANVVANEMGAKIKITSGPAIERAGDLAAILTNLQPNDVLFIDEVHRLNRAVEEVLYPAMEDFALDLVVGKGPGARSLRLNLPRFTVIGATTRLALLTSPLRDRFVAVHRLVFYSDAAMTEIVSRSARILGVPISPEGAREIGRRARGTPRIANRILRRVRDYAQVVANGEITLAVAREALAQLEIDELGLDENDRRLLRAIIELFNGGPVGLNTLAAALAEEVDAIEDVYEPFLLQLGFLQRTPRGRVATRRAYEHLGLPFPERSLPLEDESGPQQGTLF
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
B8G5S6
A3QCG6
DER_SHELP
GTP-binding protein EngA
Shewanella
MIPVVALVGRPNVGKSTLFNRLTRTRDALVADYPGLTRDRKYGRAHLSGYEFIVVDTGGIDGTEEGIETRMAEQSLAAIEEADVVLFLTDARAGLTAADEAIAEHLRRREKTTFVVANKVDGIDADSACGEFWALGLGEVYQMAAAQGRGVTNMIEYALTPYAEAMGLTRDGEGEEEADERQYTEEEAEAEQQRLQDLPIKLAIIGKPNVGKSTLTNRILGEERVVVYDEPGTTRDSIYIPLERDGQEYVIIDTAGVRRRSKVHETVEKFSVIKTLKAVEDANVVLLVVDAREGIAEQDLGLLGFALNVGRALVIAVNKWDGIDQDVKERVKSELDRRLGFIDFARIHFISALHGTGVGHLFESVEEAYESATRRVSTSMLTRIMQMAQDDHQPPLVNGRRVKLKYAHAGGYNPPIVVIHGNQVKKLPDSYKRFMMNYYRRSLKVMGTPIQVRFQEGGNPFEGLNTKKLTVSQERRRKRMMSHIKDKKK
GTPase that plays an essential role in the late steps of ribosome biogenesis.
A3QCG6
Q1H4M0
RS5_METFK
30S ribosomal protein S5
Methylobacillus
MAKVEIEQQQTDGLREKMIGVNRVTKVVKGGRIMSFAALSVVGDGDGGVGMGKGKAREVPVAVQKAMDEARRSMIKVSLNNGTLYHAVTGVHGAAKVFIQPASEGTGIIAGGAMRAIFEVMGVTNVLAKCIGSTNPYNVVRATLNGLKSMNTPAEIAAKRGKSVEEIRG
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.
Q1H4M0
H2A0N4
PIF_PINMG
Aragonite-binding protein
Pinctada
MQVPYLQIVFLLTAVFGIGVKSDDCKTADLVVNVDGSDDVSDREFDKLKRAMLMLVRGLSIDDSQIRLGMVTYGSEIGDSIPLQGDRLDLARTIRYMKKPGGPCKPFKGIGETRKMFSSRGRFNVPHVTLNLGGDIVDSEVRDLMDETDKARDEDIKVMAIGLGTKVERDEIEGIAWDKEQAYFMDDADDLVRRVKEIPDYLCKIIKAKKPRKSASKKSKTKPAKKPDSDIVGKSPGFHSLQRTDDKPKMSKKVEVKELCDDAEWVEDVGYGSVPTRCEDFVMCQNVSGSLRKTLKTCPYGQFWSRARTSCVLTEDEDCSDDLCKTMLLPSRDYDVSCRAYWKCENGKSVARCCPSGMAYEPGKGCVLDSDCDEECPPKGDSDNGDDDDDDNDDDDNEYDDDDDEMEYNPNCPLRPIKGSPEKFKQHTGDDNWEEFDCAPGTLFSSRDCACSILGRPEKDDNGKNEDDTSKVCEPELYLPFCDDLHDYSGKETHVENEGDAVIIENGKAYFNGRAGLKIPRFSGVPYGKSVFIKMKYKEDEDDDKKRNDDDKKLRIKRDERGRKGYRKGGRKDDRNGKRRDDRIGKRRDDRIFDDRKGRRTDDRKGDRRDRIDDRNGRRTDDRKDNRRDDRKDNRRDDIKDNKRDDKKDNADEPMTLISNGECDNFELHDCFEKPSLAITTGKKFAGFSVSSTERDEVDLEVDNDKKGYLWNKDKKDKDDKNRRDKDKNGDRTDDKKSLDDLVKEIERRKSDDKKSFDDLVKEIERRKSDDKKSFDDLVKEIERRKSDDKISLDDLVKEIKRRKSDDKGNGRRKDDNKNDEDDDKKGWKTVSLKINNGHIRGRRDDREDKDIMDGDLKTTFSGFQIGQGASNKNFKGYMDEVYIYFCDPGKEADFDEEDDNGDDDDDDDDDDDKDNDAGDDNKDDNNNNGRKDDNNNDGRKDDNNKKDDKDRSDKNGGKDDKDKDTKDKFSDKDNGKDNEDADRDINDNDKLYRRAMKKCDFVNKNVEKWLDKR
Pif97 contains a chitin-binding domain that allows for attachment of the entire complex to the chitin-containing organic framework.
H2A0N4
Q49KY5
CYF_EUCGG
Cytochrome f
Eucalyptus
MQTKNTFSWIKKEIIRSISVSLMIYIIARTSISNAYPIFAQQGYENPREATGRIVCANCHLANKPVDIEVPQAVLPDTVFEAVVRIPYDMQVKQVLANGKRGGLNVGAVLILPEGFELAPPDRISPEMKEKIGNLSFQSYRPNKKNILVIGPVSGQKYSEVTFPILSPDPATNKDVHFLKYPIYVGGNRGRGQIYPDGSKSNNTVYNATAAGVVSKIIRKEKGGYEITISDASDERQVVDIIPPGPELLVSEGESIKLDQPLTSNPNVGGFGQGDAEIVLQDPFRVQGLLFFLASVILAQIFLVLKKKQFEKVQLSEMNF
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Q49KY5
Q5WWT0
SERC_LEGPL
Phosphohydroxythreonine aminotransferase
Legionella
MNSRVFNFGAGPAMLPEEILKEAQEEFLNWRNTGMSILEIGHRTPEIISLLSTAEQSLRELLNIPKNYHVLFLGGAARTQFAMIPMNLLRPGDDAAYFITGIWSKMAYHEANLLKKAYYLSSEEKEGFVSIPDYQKWELKSNTAYVYYTPNETINGVRFPYVPKTGGVPLVADMTSCLLSEPININQYGLIFAGAQKNIANAGLTVVIIHEELLKNQPEPVIPTMLNYKNHAEHRSLYATPPVFNCYLASKMFEWIKTQGGIEGLFQRNCLKAAKLYQYLDSTDFYLTPVFKEARSIMNICFSLCYPDLEHKFLDMANERGLKALKGHRFTGGLRASLYNAMPMAGVDALIEFMSEFAKENG
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Q5WWT0
A6MVX4
RPOB_RHDSA
Plastid-encoded RNA polymerase subunit beta
Rhodomonas
MSSTKLSTSILPDLVEIQRASFCWFLEEGLAEEIKSFSPITDYTGNLELHFFGDQFKLKCPKYNLLESKRRDATYSVQVYVPARLINRDTGIIKEQEVFIGDLPLMTDRGTFIINGAERVIVNQIVRSPGIYYKSETDRQGRRTYSGSLISNRGAWVKFETDRNDLVWVRIDKTRKIPAHVFLKAMGLSDSDIYNGLRHPEYLKKSFRVEGNYTTEEALIQMYTKLRPGEPATVNGGQQILYSRFFDPKRYDLGKVGRYKINKKLALSIPENIKVLTPQDTLSAIDYLINLKFNIGETDDIDHLGNRRVRSVGELLQNQVRVGLNRLERIIRERMTICDSESLAPNTLVNPKPIIAAIREFFGSSQLSQFMDQTNPLAELTHKRRISALGPGGLNRDRAGFAVRDIHPSHYGRICPIETPEGPNAGLIGVLATHARINSYGFIETPFYQVINGKVVSDGNPVYLTADQEDNFRIAPGDIAIDENNAINNDIVPVRYRQEFTITKPEQIDYIQVSPIQVISIATSLIPFLEHDDANRALMGSNMQRQAVPLLYPESPLIGTGIEAQAARDSGMVVVSYQDGRVTYVSANKICITDDEGKEVVYYLQKYQRSNQDTCINQRPSVWLGEKVVAGQVIADGAATEGGELALGQNILIAYLPWEGYNYEDAFLISERLVYNDVYTSVHIEKYEIEARQTKLGSEEITRELPNIGEYSLRKLDDNGIIVIGSWVEVGDILVGKVTPKGESDQPPEGKLLRAIFGEKARDVRDTSLRVPNGGRGRVLDVRIFTREKGDELPTGANIVIRVYVAQTRKIQVGDKMAGRHGNKGIISRILPRQDMPYLPDGTPVDLVLNPLGVPSRMNVGQIFECLLGLAAENLDKRFKIIPFDEMNGAEASRVLVNEKLMEARTLTEKDWIFDLRHPGKTQLFDGRTGEAFDNPVTVGISYMLKLVHLVDDKIHARSTGPYSLVTQQPLGGKAQHGGQRLGEMEVWALEAFGASYTLQELLTVKSDDMQGRNETLNAIVKGKPIPRPGTPESFKVLMRELQSLGLDIGAYKIENLPDGQTRGIEVDLMSNLHNRRVPSRPTYESITREDLENSFA
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A6MVX4
A7I3D6
FABH_CAMHC
3-oxoacyl-[acyl-carrier-protein] synthase III
Campylobacter
MKNAAMLSIGAYVPPYELSNFDLEKMVETSDEWIVKRTGIHTRHIAKNETAGDMAAKAADLAISRSGISKEEIDAIICATITPDFFCMPSTACITAEKLGLNKGITAFDISAACSGFIYLLEIGSALIKSGAKKNVLIIGTEKLSSIVDWKDRATCVLFGDGAGAAVLSCMDNKNNGISKPYGIIDIHTASDGNKAELLMTPTKNSNIKDIADENLGFLHMKGNEVFKIAVQTLSNDVVKILKKNNVKPEEIDLFVPHQANFRIIEAVKNRLNFTDNQCVVTVGKYGNTSSASIPIALNEAYENGRLKNGSLILLDAFGGGFTWGSALIRFGL
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
A7I3D6
Q4R3Q1
IF4A3_MACFA
Eukaryotic initiation factor 4A-III, N-terminally processed
Macaca
MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPARELAVQIQKGLLTLGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development.
Q4R3Q1
B5BLB2
LEUD_SALPK
Isopropylmalate isomerase
Salmonella
MAEKFTQHTGLVVPLDAANVDTDAIIPKQFLQKVTRTGFGAHLFNDWRFLDEKGQQPNPEFVLNFPEYQGASILLARENFGCGSSREHAPWALTDYGFKVVIAPSFADIFYGNSFNNQLLPVKLSDEQVDELFTLVKANPGIKFEVDLEAQVVKAGDKTYSFKIDDFRRHCMLNGLDSIGLTLQHEDAIAEYENKQPAFMR
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
B5BLB2
Q8NBR6
MINY2_HUMAN
Protein FAM63B
Homo
MESSPESLQPLEHGVAAGPASGTGSSQEGLQETRLAAGDGPGVWAAETSGGNGLGAAAARRSLPDSASPAGSPEVPGPCSSSAGLDLKDSGLESPAAAEAPLRGQYKVTASPETAVAGVGHELGTAGDAGARPDLAGTCQAELTAAGSEEPSSAGGLSSSCSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLPGAVPLCKEEEGEETAQVLAASKERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFSTMTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLRPPSDPETVYKGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQEQAAAAAAAASTQAQQGQPAQASPSSGRQSGNSERKRKEPREKDKEKEKEKNSCVIL
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins . Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' . May play a regulatory role at the level of protein turnover .
Q8NBR6
L0T905
RSEA_MYCTU
Sigma-E anti-sigma factor RseA
Mycobacterium tuberculosis complex
MADPGSVGHVFRRAFSWLPAQFASQSDAPVGAPRQFRSTEHLSIEAIAAFVDGELRMNAHLRAAHHLSLCAQCAAEVDDQSRARAALRDSHPIRIPSTLLGLLSEIPRCPPEGPSKGSSGGSSQGPPDGAAAGFGDRFADGDGGNRGRQSRVRR
An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigE. ECF sigma factors are held in an inactive form by an anti-sigma factor.
L0T905
B7GZQ9
QUEF_ACIB3
PreQ(0) reductase
Acinetobacter calcoaceticus/baumannii complex
MSVEQSLLGKETQYPTSYQPDVLFPIARAQSREKYAHIQGITQGKDWWHVFEISWLNAHGIPQVAIGRITLPASSPNLIESKSLKLYFNSLNFTQFDSTQSFIETVEKDLSAAAGAKVELTLFQVDDLEISKPQGICIDDLMPERLEQHPDATLLKLDESGEEIEVELYSHLLRSNCPVTGQPDWGTVFIRFKGKKPCYRSLLAYIISYRQHNGFHEQCVEQIFADIWQNLQPEKLMVYATYTRRGGLDINPCRVSDLTWMPKPIRLARQ
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
B7GZQ9
A4WQD9
DDL_CERS5
D-alanylalanine synthetase
Cereibacter
MAGRSGRTFPRVAVLMGGTSSEREVSLSSGHSCSAALRDAGYEVTEVDAGPDLARVLAEVQPDAVFNALHGRWGEDGCVQGLLEWLRIPYTHSGVLASALAMDKARAKEVFAAAGLPVTQSVIATPDEVQAGHVLPPPYVVKPNCEGSSVGVYIVQADANGPPRLAPDMPRDLMVETYIPGRELTVTVMGDRALAVTDIVTDGWYDYDAKYRPGGSRHVVPAELPAEITDACLDIALRAHRALGCRGISRSDLRWDESRGAEGLILLETNTQPGMTPTSLSPEQAAHCGLSFPEFCAWMVEDASCNR
Cell wall formation.
A4WQD9
Q7VUH1
KPRS_BORPE
Phosphoribosyl pyrophosphate synthase
Bordetella
MIFTGTANTRLAVDVVNHLDMSLGKMTVGRYSDGEVMVEINENVRGKDVFVLQPTCAPTNDNLMEIMVMVDALRRASAGRITAAIPYFGYARQDRRPRSARVAISAKVVANMLQVAGVDRVLTMDLHADQIQGFFDIPVDNIYAGPILLGDIWRRNFSNLVVVSPDIGGVVRARALAKQLEADLAIIDKRRPRANVSEVMNIIGEVDGRTCIIMDDMVDTAGTLCKAAQALKDRGAGAVYAYCTHPVLSGGAIERIETSSLDELVVTDTIPLSEQAQACGKIRQLSCAALLGETILRISNAESVSSLFAD
Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).
Q7VUH1
O25150
CMOA_HELPY
Carboxy-S-adenosyl-L-methionine synthase
Helicobacter
MKDTLFNESLNKRFCFDEKVAHVFDDMLERSIPYYHEMLNLGAYFIAQNLKENIYPKSLPKPLIYDLGCSTGNFFIALNRQIQQEIELVGIDNSMPMLKKAQEKLKDFNNARFECMDFLEVEFKEASAFSLLFVLQFVRPMQREVLLKKIYNSLALNGVLLVGEKIMSEDRILDKQMIELYYLYKQNQGYSHNEIAFKREALENVLVPYSLKENVALLESVGFKHVEALFKWVNFTLLVARKT
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
O25150
B9DPQ3
PYRR_STACT
Uracil phosphoribosyltransferase
Staphylococcus
MSERIVLDEAAMKRTLMRMAHEILEYNRGTKDLVLLGVKTRGEFLAKSIQSKIQQIENTTVPTGTIDITQFRDDLELPTPKISEKSFVIDVDITDKVVIIIDDVLYTGRTVRASLDAILLHSRPQKIGLAALVDRGHRELPIRADFVGKNIPTARDEAVSVYVKETDGRNAVIIE
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
B9DPQ3
Q16674
MIA_HUMAN
Melanoma inhibitory activity protein
Homo
MARSLVCLGVIILLSAFSGPGVRGGPMPKLADRKLCADQECSHPISMAVALQDYMAPDCRFLTIHRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAARLGYFPSSIVREDQTLKPGKVDVKTDKWDFYCQ
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
Q16674
B1ZDN3
LEU1_METPB
Alpha-isopropylmalate synthase
Methylorubrum
MANTTESAKDRVVIFDTTLRDGEQCPGATMTLDEKLAVAELLDAMGVDIIEAGFPIASNGDFEAVSEIARRTKRATIAGLARAIPADIARAGEAVRHAKAGRIHTFVSTSAIHLAHQMRKTQDEVIEIILKTVTQARDLVEDVEWSAMDATRTDIDYLCRCVEAAIRSGATTINLPDTVGYATPQEYGAMFRQVRERVPNSDKAIFSVHCHNDLGLAVANSLAGLEGGARQIECTVNGIGERAGNAALEEIVMAIRTRADVMPYDTGIDTTMLTRASKLVSHAANFPVQYNKAIVGRNAFAHESGIHQDGMLKHSETYEIMTPASVGLSKTSLVMGKHSGRAAFKSKLAELGISLSDNQFQDVFERFKDLADRKKHVYDEDIEALVDEKLATAHDRIKLLSLSVIAGTRGPQRATMKIEMDGRTFTEEADGNGPVDAVFNAIHEIVPHDAVLELYQVHAVTEGTDAQAEVSVRLKAGERSVTARGADPDTLVASAKAYLSALNKLSAASVRLHAQHAAVV
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
B1ZDN3
P00852
ATP6_EMEND
F-ATPase protein 6
Aspergillus subgen. Nidulantes
MYQFNFILSPLDQFEIRDLFSLNANVLGNIHLSITNIGLYLSIGLLLTLGYHLLAANNKIIPNNWSISQEAIYATVHSIVINQLNPTKGQLYFPFIYALFIFILVNNLIGMVPYSFASTSHFILTFSMSFTIVLGATFLGLQRHGLKFFSLFVPSGCPLGLLPLLVLIEFISYLSRNVSLGLRLAANILSGHMLLSILSGFTYNIMTSGILFFFLGLIPLAFIIAFSGLELAIAFIQAQVFVVLTCSYIKDGLDLH
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
P00852
C6DF35
ARGP_PECCP
HTH-type transcriptional regulator ArgP
Pectobacterium
MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENLFGQPLLVRTIPPRPTEQGQKLLALLHQVELLEEEWLGNETNSDIPLLLSLAVNADSLATWLLPALQPVLVDSPIRLNLQVEDETRTQERLRRGEVVGAVSIQSQPLPSCLVDKLGALDYLFVASPTFAARYFPNGVTRSALLRAPAVAFDHLDDMHQAFLQQNFDLSPGSVPCHIVNSSEAFVQLARQGTTCCMIPHLQIEKELANNELVDLTPGLFQRRMLYWHRFAPESRMMRKVTDALLAHGHQVLRQS
Controls the transcription of genes involved in arginine and lysine metabolism.
C6DF35
Q2QNM1
MCM7_ORYSJ
Minichromosome maintenance protein 7
Oryza sativa
MAATATKTIDFAAERALAKDFLANFAGPRGEPKYLNILQDVANRKIRAVQIELDDLFHYKDADDEFLQRVTENTKRYIGIFADAIDELMPESTEAYAVDEDRDILMTQRVDEGADGGADGTDPLQRMPPEIRRFFEVYIKAFSKVTPLTIRQVKASNIGQLVKISGIVTRCSDVKPLMQVAVYTCEECGFEIYQEVTARVFMPLFECPSQRCKLNKAKGNLILQLRASKFLKFQEVKLQELAEHVPKGHIPRSLTVHLRGELTRKVAPGDVVEMSGIFLPMPYYGFRAMRAGLVADTYLESMSITHFKKKYEEYELKGDEQEQIDRLAEDGDIYNKLARSLAPEIFGHEDVKKALLLLLVGAPHRKLTDGMKIRGDLHICLMGDPGVAKSQLLKHIINVAPRGVYTTGRGSSGVGLTAAVQKDPVTNEFVLEGGALVLADMGICAIDEFDKMEESDRTAIHEVMEQQTVSIAKAGITTSLNARTAVLAAANPAWGRYDMRRTPAENINLPPALLSRFDLLWLILDRADMETDLEMARHVVHVHQNLESPALGFTPLEPPVLRAYISTARRVVPSVPRELEEYIATAYSSIRQEEAKSNAPHSYTTIRTLLSILRISIALARLRFSETVAQSDVDEALRLMQMSKYSLYSDDRQRSGLDAISDIYSILRDEAARTNSMDVRYAHALNLISRKGYSEAQLKECLEEYASLNVWQIHPNTFDIHFIDA
Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.
Q2QNM1
Q96M32
KAD7_HUMAN
ATP-AMP transphosphorylase 7
Homo
MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENKSAMLEASSTKVKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNITESSQQMEEAIWAVSALSEEVSHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRRRKSHPNFLDHINAEKMVLKFGKKARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNPEAQ
Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function.
Q96M32
Q97QC4
CRCB2_STRPN
Putative fluoride ion transporter CrcB 2
Streptococcus
MKKEQFYPLGIFLAAMLGGLVRYLVSTWLPASPDFPWGTLFVNYLGIFCLIYLVKGYLVYKGTSKGLILALGTGFCGGLTTFSSLMLDTVKLLDTGRYLSLILYLLLSIGGGLLLAYYLGRKKW
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Q97QC4
Q6LUJ8
FTSH_PHOPR
ATP-dependent zinc metalloprotease FtsH
Photobacterium
MWLQVTNCSTLHSSLSYCGANTLSDMAKNLILWLVIAVVLMSVFQSFGPSDSAGRQVDYTTFVREIGQDQIREARFNEREITVFKRDNTRYVTYLPVFNDQKLLDDLINANVKVLGTPPEEPSLLASIFISWFPMLLLIGVWVFFMRQMQGGGGGKGAMSFGKSKARMMSEDQIKTTFADVAGCDEAKEDVKELVDYLRDPSRFQKLGGKIPTGILLVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGVGGGHDEREQTLNQMLVEMDGFEGNEGVIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRKVPLEGDVEPSLIARGTPGFSGADLANLVNEAALFAARGNKRVVSMQEFELAKDKIMMGAERKSMVMSEDQKESTAYHEAGHAIIGRLVPDHDPVYKVSIIPRGRALGVTMYLPEKDRISHSREFLESMLSSLYGGRLAEELIYGVDKVSTGASNDIERATDIARKMVTQWGFSEKMGPVLYADDEGEVFLGRSVTQTKHMSDDTARAIDMEIRALIDRNYERAREILAQNMDIMHAMKDALMKYETIDAAQIDDLMARKSEIRAPKGWGDTDDVMKSSPTTSESAPEAKTESAPEAKAEANVETEEKPVAADSEELKPKAEQAPKEDDKPQA
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
Q6LUJ8
A9MU86
OTSA_SALPB
UDP-glucose-glucosephosphate glucosyltransferase
Salmonella
MSRLVVVSNRIAPPDNKGGAGGLAVGVLGALKAAGGLWFGWSGETGNEDEPLKKVTKGNITWASFNLSEQDYEDYYCQFSNAVLWPAFHYRLDLVQFQRPAWEGYMRVNALLADKLLPLIKENDIIWVHDYHLLPFASELRKRGVNNRIGFFLHIPFPTPEIFNALPPHDELLEQLCDFDLLGFQTENDRLAFLDSLSSQTRVTTRSGKQHIAWGKDFQTEVYPIGIEPDEIALQAAGPLPPKLAQLKAELKNVKNIFSVERLDYSKGLPERFLAYEALLENYPQHRGKIRYTQIAPTSRGEVQAYQDIRHQLETEAGRINGKYGQLGWTPLYYLNQHFDRKLLMKIFRYSDVGLVTPLRDGMNLVAKEFVAAQDPANPGVLVLSQFAGAANELTSALIVNPYDRDDVAAALNRALTMPLAERISRHAEMLDVIVKNDINRWQERFIHDLKEVTPRSPERQQQNNVATFPKLA
Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor.
A9MU86
Q8TWR5
IF2B_METKA
eIF-2-beta
Methanopyrus
MVEYDYEELLERAYEQLPEEVLEDRRFEMPKPKVSVEGKTTVIRNFKEISKKLDRDPEHITKYFLKELGTAGHVDGGRLILHGVYHPKLVEEELKNYVEEFVLCPECGKPDTKLVREDRQWILKCEACGAWSSVRRLK
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
Q8TWR5
B0R9H2
TH11_HALS3
Probable transposase for insertion sequence element ISH11
Halobacterium
MSPATLQDDPSVDSFFNVVETETLALFEHLSFEFLEEFDVFAPAETGRTRDHEPPELMRGFLHCYYKDIYGIRPVERELRNTVVWLSCGFDRPPSRDAVDRFLTDLEHVVNKVFDHLVEQAALRGLLDLTYCIDSTDVRAMPADQDASKCYDPTDDEYYHGYGCTIVSTGQKIPIAAEFTESKQAPEETAMRVTRDALAVAKPIWMVGDSAYDTLDWHDHLLAAGVVPVAPYNARNTDDPKDIEYRVEDRIEQHSEDVQLKQSTLDETYNRRTGVERTNESVKDCGLGRTHARGRVHARAQVFLALCLRLVVAITNYERGDNPGSPIITV
Involved in the transposition of the insertion sequence ISH11.
B0R9H2
B8D9H0
RL21_BUCA5
50S ribosomal protein L21
Buchnera
MYAVFISGGKQYRVVKNQIIRLEKLNSPLGTTIEFDKILMLFDKDSIKIGTPFVEGGTIKAHIQNHGRLKKIKIIKFNRRKHYKKQQGHRQYFTDVKIIDINSIKGEV
This protein binds to 23S rRNA in the presence of protein L20.
B8D9H0
C5C9T9
RS15_MICLC
30S ribosomal protein S15
Micrococcus
MALDPAVKQQIIKEYATHEGDTGSPEVQIAVLSRRIKDLTEHLKEHKHDHHTRRGLMGLVGRRRRMLGYLQNVDIERYRALIERLGLRK
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
C5C9T9
Q11I83
ILVC_CHESB
Ketol-acid reductoisomerase type I
unclassified Chelativorans
MRVYYDRDADLNLIKSKKVAIIGYGSQGRAHALNLKDSGAKDLAVALRPGSASAKKAEADGLKVMSVAEAAGWADLMMMATPDELQAGIYNNEIAPNIRDGAAIAFAHGLNVHFGLIEPKKTVDVLMIAPKGPGHTVRSEYQRGGGVPCLVAVHHDASGNALDLALSYACGVGGGRSGIIETTFREECETDLFGEQVVLCGGLVELIRAGFETLVEAGYAPEMAYFECLHEVKLIVDLIYEGGIANMNYSISNTAEWGEYVSGPRIITPETKAEMKRVLKDIQTGKFTAEWMQEWHSGAARFKATRRLNDSHQIEEVGEKLRAMMPWISKNKLVDKAKN
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
Q11I83
A8AN88
UBIA_CITK8
4-HB polyprenyltransferase
Citrobacter
MEWSLTQNKLLAFHRLMRTDKPIGALLLLWPTLWALWVATPGVPQLWILAVFVAGVWLMRAAGCVVNDYADRKFDGHVKRTANRPLPSGAVTEKEARTLFVVLVALSFLLVLTLNTMTILLSIAALALAWVYPFMKRYTHLPQVVLGAAFGWSIPMAFAAVSESVPLSCWLMFLANILWAVAYDTQYAMVDRDDDLKIGIKSTAILFGRHDKLIIGILQIAVLALMALIGWLNGLGWGYYWSVLVAGALFVYQQKLIVGREREACFKAFMNNNYVGLVLFLGLAMSYVG
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
A8AN88
D2Y297
H1624_CYRHA
Peptide F4-19.87
Haplopelma
MNTVRVTFLLVFVLAVSLGQADKDENRMEMQEKTEQGRSYLDFAENLLLQKLEELEAKLLEEDSEESRNSRQKRCIGEGVPCDENDPRCCSGLVCLKPTLHGIWYKSYYCYKK
Probable ion channel inhibitor.
D2Y297
A5EDB2
UREG1_BRASB
Urease accessory protein UreG 1
unclassified Bradyrhizobium
MLHALRQAKAQATATVAARVGIGGPVGSGKTALIEALIPVLQRRGVDFAVVTNDLVTKEDAERLRRSGLIDPDRVSAVEAGACPHTVIREDPTLNIAAGDELEARFPGVELILFESGGDNLASTFSLDLVDWWIFVIDVAGGDDIPRKRGPGLLRCDLLVVNKIDLAPHVGVDLDRMLADARQVRGGKPVIATNLKAGTGVEAVADAISAAVLFRI
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
A5EDB2
Q818P5
MNTR_BACCR
Manganese transport regulator
Bacillus cereus group
MPTPSMEDYIEQIYLLIDEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTTKGKKIGERLVYRHDLLEQFMRIIGVDESKIYNDVEGIEHHLSWEAIDRIGDLVQYFEQDTVRVETLRGVQRANEEKSN
Central regulator of manganese homeostasis.
Q818P5
A8FKR5
RS12_CAMJ8
30S ribosomal protein S12
Campylobacter
MPTINQLVRKERKKVLEKSKSPALKNCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTSGFEVISYIGGEGHNLQEHSIVLVRGGRVKDLPGVKYHIVRGALDTAGVAKRTVSRSKYGAKRPKAGTAK
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
A8FKR5
B1ZWN7
ATPG_OPITP
F-ATPase gamma subunit
Opitutus
MASTRDIRRRIKSVKNTRQITKAMELVAASKMKKAQQAAVAGRPYAELMAQMLATLGDRVEEAQHPFLVQREVKTRGIILITTDKGLAGPLNANLFKLVTDIQSPAKYVVVGRKGAQFIARTRRDLLAEFQVSDRAAFAEVKVVVEFMTKQFIDGVVDSVEVIWPRFKNTLVQIPTIAQLLPLRGVQHAVESLQHGTGVSAPRSPAVEAQMLFEPDPVSVLSALLPLYINREVYHQVLDAKASEHSARMVAMKTAKDNATKLLDDLTLEYNKARQAGITQEIIEIAAAQFAAAS
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
B1ZWN7
A4QJZ9
PSBA_ARAHI
Photosystem II Q(B) protein
Arabis
MTAILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANEGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSTNG
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
A4QJZ9
B6HV34
ADRF_PENRW
Andrastin A biosynthesis cluster protein F
Penicillium chrysogenum species complex
MSLLQDIVLIITGSASGIGLATATAALSQGAKILGVDVSWAPVSLTEHASYKFIQANLTHEATPKQVVETCIKEFGRIDGLLNIAGIMDQNSSVDSLTDDMWERCIAINLTAPVKLMREVIPIMRQQKSGSIVNVGSKAATSGAASGVAYTASKHGLMGATKNVAWRYKQEGIRCNAVCPGGVPTGIVQASDPTTWDKDALATMSHIHQAHAADRQEGLGVEAEDIANCLLFLVSSQSKRINGAIIPVDNAWSVI
Short chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of andrastins, meroterpenoid compounds that exhibit inhibitory activity against ras farnesyltransferase, suggesting that they could be promising leads for antitumor agents (Ref.2). The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase adrD via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Ref.2). DMAO is then converted to farnesyl-DMAO by the prenyltransferase adrG (Ref.2). The methyltransferase adrK catalyzes the methylation of the carboxyl group of farnesyl-DMAO to farnesyl-DMAO methyl ester which is further converted to epoxyfarnesyl-DMAO methyl ester by the FAD-dependent monooxygenase adrH (Ref.2). The terpene cyclase adrI then catalyzes the carbon skeletal rearrangement to generate the andrastin E, the first compound in the pathway having the andrastin scaffold, with the tetracyclic ring system (Ref.2). The post-cyclization tailoring enzymes adrF, adrE, adrJ, and adrA, are involved in the conversion of andrastin E into andrastin A. The short chain dehydrogenase adrF is responsible for the oxidation of the C-3 a hydroxyl group of andrastin E to yield the corresponding ketone, andrastin D. The ketoreductase adrE stereoselectively reduces the carbonyl moiety to reverse the stereochemistry of the C-3 position to yield andrastin F. The acetyltransferase adrJ is the acetyltransferase that attaches the acetyl group to the C-3 hydroxyl group of andrastin F to yield andrastin C. Finally, the cytochrome P450 monooxygenase adrA catalyzes two sequential oxidation reactions of the C-23 methyl group, to generate the corresponding alcohol andrastin B, and aldehyde andrastin A (Ref.2).
B6HV34
Q0W1L9
THIM_METAR
4-methyl-5-beta-hydroxyethylthiazole kinase
Methanocella
MDARSLSGILTEVREKRPLVHHITNYVTVNDCANVTLCIGAAPVMAHAHDEVAEMVAMAGALVLNIGTLDHRQVESMLAAGHRANELNIPIILDPVGAGATRLRTETAKTLLHKLHVSVLKGNAGEIATLAGAEGKVRGVDSAGVSGDPAEFARGLAEKLGLVVAVSGATDIVTDGKRLIYVDNGHEMMGKLSGTGCMASSISGAFAAASKDYVTSTAAALASFGVAGEKAAKRCEGPASFKIALLDEIYRLTADEVAHNIKVRFA
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
Q0W1L9
B1JFW2
NANK_YERPY
N-acetyl-D-mannosamine kinase
Yersinia
MGKGLALDIGGTKIAAAVVTESGMLIGRQQIATPRGGAGQLAAALETLIAPYRHQVDFIAVASTGIISGGRLTALNPANLGGLADFPLYDCIRSISDLPCVLLNDGQAAAWAEYQALGDKNDNMMFVTVSTGVGGGIILNKKLLVGQRGLAGHIGHTLSDPHGVLCGCGRRGCVESVASGTAIGAETLGWKQPVSAATVFDMAQQGDAQAGKVINRSAAAIAQMLADMKMALDLEVVILGGSVGLAVGYLERVVAAQKTLPGIYRVPVQEAHHRQDSGLLGAALWARASL
Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P.
B1JFW2
P53938
EOS1_YEAST
ER-localized and oxidants sensitive protein 1
Saccharomyces
MTWILSTGMGPHEDKYAKHERATFKKTYSSMKTLSLNHLTAKQHMLMALCRDISLLPPLTYIFTSLRKAWRVSMRTSITLYEPQSLRDAFTYFWQKLNSAYDNNSSFEGASQKAVNGDGKDSLLLSALTTARASEYLLCSLWCLVSLYLSYAILDSLMVRWIVKYSTVAAILRMFSMSLIIVTLELLLLSSLSPELDYFLHTWILISCVLTAVYIWQSYLTSDLRYIRNQEGEVQEDTNVPEETEDYEDGEDDADEDSHVVVADESTVDVPSNDSLSDNSDGGLFPVNRPSVSHSQSPKRPKKYPKKAFNFTTKRTIDLYKITVLCVVPVGLASFITMLGLLRNLFIQRLDVEQLERILHEMHPPA
Involved in oxidative stress resistance and N-glycosylation.
P53938
P56168
MT21_BRAJU
Metallothionein-like protein type 2, MT2-4/MT2-25
Brassica
MSCCGGNCGCGSGCKCVGCGGCKMYPDLSFSGETTTTETLVLGVAPAMNSQFEASGETFVAENDACKCGSDCKCNPCTCK
Metallothioneins have a high content of cysteine residues that bind various heavy metals.
P56168
Q6LWZ4
MTRE_METMP
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E
Methanococcus
MDPTLISLGALALAGAAATVSGCAEDLESDVGSQSNPNSQVQLGPQMGNIHRYFNKAISGEPVSYGLYVAVAGTIAWALINAGLNVVLAIIVGAGVAAIVHGAYSVSAFLGRTVGQSKKFGQPVYMDVLTSHIGPIVGHGFIAVFTMTLAAYLATTALGNPFPLPLVSLIFGITVGAIGSSTGDVHYGAEREYQKYPFGGGIPVANQGDIDIYAEYGVRNGLDSSYFCSRFGGPLTGLCFGLIIFLDGWRSILGNIIGGDLVTKTSIALLVGLLVVAVAAVINRKLEVYARNKYGPYRN
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Q6LWZ4
O82213
VAP31_ARATH
Vesicle-associated protein 3-1, N-terminally processed
Arabidopsis
MSNNELLEIEPMYLQFPFELKKQMSCSLYLTNKTDNNVAFKVKTTNRNNYCVRPNYGLILPKSTCKVLVTMQAQKEVPSDMQSFEKFMIQSVLASPGVTAKEVTREMFSKESGHVVEETKLRVTYVCSTTTNITSSPRTRRGFIFQCFC
May play a role in vesicle trafficking.
O82213
Q7Z4L9
PPR42_HUMAN
Leucine-rich repeat-containing protein 67
Homo
MVRLTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSSKNEDASNSLISNFKTMHHIVPVYYPQVGKPKLAFFSEIQRYPVNANASPESS
Regulates phosphatase activity of protein phosphatase 1 (PP1) complexes in the testis.
Q7Z4L9
Q7VN63
TATA_HAEDU
Sec-independent protein translocase protein TatA
Haemophilus
MGGISIWQLLIIVAIIVLLFGTKKLRTLGTDLGESVKGFKKAMAEDKSQDANFDKVEAKESTSTTEKTKEKEQA
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q7VN63
A3PK84
METAA_CERS1
Homoserine transacetylase
Cereibacter
MPITLPATLPAFDVLTHEGVMVMTPERAARQDIRPLRIGLLNLMPKKIQTENQFARLIGATPLQIDFQLIRMTEHQTKNTAAEHMEAFYRPFQEVKHEKFDGLIITGAPIEHLDFADVTYWDELCEVMDWTQTNVQSTFGVCWGGMAMIYHFHRVQKHRLQAKAFGCFRHRNVAPTSPYLRGFSDDFVIPVSRWTEMRQAEIDAAPGLRTLLASDEAGPCLVEDPGHRALYIFNHFEYDSDTLKQEYDRDVANGKPINVPANYYPDDDPSKPPLNRWRSHAHLLYGNWINEIYQSTPYDPQQIGR
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
A3PK84
A9L591
RLMKL_SHEB9
rRNA (guanine-N(7)-)-methyltransferase RlmK
Shewanella
MLNFFAAAPKGFEYSLAQELTEFGATEVKESVAGVYFTASLALAYRITLWTRLASRIVLVIYKGSCESAEQLYNAAYCVDWPAHFSNKSTFSIDFHGTGGFLNNTQFGALKIKDAIVDRFRDDDIERPNVSRVDAEFKVDAHFRNGVITIAMNFSGPSLHQRGYRSTTGEAPLKENLAANMLVRSGWQASPSTLLDPFCGSGTVLIEAALMAADIAPGLQRSRFGFEHWRRHDKAVWQEIVEEAKARASLGVKRCEIKFYGSDIDSRLVALAKRNAENAGVLELIEFKVADALTIAPPAESGYLITNPPYGERLGNVSELLQLYYQLGDKFKKEFGGWKVAMLCSDIELVSSLKLKADKQMKMFNGALECAFNIYTLHANSTRRDTPVLPDGVDIADIAPAFANRIKKNAKLLEKWAKKEGIDSYRIYDADIPEYNVAVDKYLDYVIIQEYMAPATIPEAVTKRRLSDVLLALPSAIGINPNKMIMKTRERQKGTSQYQKLDERKLELITTEYGAKFKLNLTGYLDTGLFLDHRLTRRLVGQKSKGRRVLNLFSYTGSASVHAALGGAKSVTTVDMSNTYIAWAKDNFALNGLQGKQYEFVQSDCMQWIRDCNEQYDLIFIDPPTFSNSKRMEDSFDVQRDHVNLLASLVKLLSPTGELVFSNNKRKFKMDIETLTKMNINVTNIDDVTLPMDYKRNPHIHNTWLITHA
Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.
A9L591
Q5HM28
ECFA2_STAEQ
Energy-coupling factor transporter ATP-binding protein EcfA2
Staphylococcus
MSIQFNQVSYIYQQGTPYEFEAIKNVSLTLEQGKYYAIIGQTGSGKSTLIQHLNALLKPTTGSVNINGLEVTNKTKDKHLRHIRKEVGIVFQFPESQLFEDSVEKEIEFGPKNFNMNLKNVKDKAFQLLLELGFSRNVMSSSPFQMSGGQMRKIAIVSILAMDPQVIILDEPTAGLDPNSKHQVMSLIKKIQIEENKTIILVSHDMDDVARYSDEVVVMNKGTIVEKSNPRNLFNQKTQLLKWHIELPKVVKLQKDIEKKYNMLFPKLAMNEEEFVKLYKEWHHEE
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Q5HM28
Q45W87
OL111_ARAHY
Oleosin Ara h 11.0101
Arachis
MAEALYYGGRQRQEQPRSTQLVKATTAVVAGGSLLILAGLVLAGTVIGLTTITPLFVIFSPVLVPAVITVALLGLGFLASGGFGVAAITVLTWIYRYVTGKHPPGANQLDTARHKLMGKAREIKDFGQQQTSGAQAS
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Q45W87
A0A455R413
ASCA_ACREG
Ascofuranone/ascochlorin biosynthesis clusters protein A
Acremonium
MAAKSRSPKRGTSEKTPLVEKEAPYQPPTKGILSKLPASWVPYAQLIRLEQPHGNYMIYFPHIIGLMYASAIRPTELSVLGHRAAIFAIWTFLMRGAGCAWNDNVDQDFDRKTERCRHRPIARGAISTTQGHVFTLILTLLGFAAIQSLPIECTYVGVGTTVLSAIYPFGKRFTHFAQVILGSTLASTIALSAYSVGLPALSKDYFVPTLCLSATIMLLVVFYDVVYARADTTDDLKSGVKGMAVRFRNHLEGLFAFITLSIAGSLTTLGYLVGMGHWFYLFSVGGLTFGLVSMVALTHWNILPGYSSGRCYAFAILNLLTGFIMEYATKDYVVGV
Prenytransferase; part of the asc-1 gene cluster that mediates the biosynthesis of both ascochlorin and ascofuranone, a strong inhibitor of cyanide-insensitive alternative oxidases and a promising drug candidate against African trypanosomiasis . The first step in the pathway is performed by the non-reducing polyketide synthase ascC that produces orsellinic acid by condensing acetyl-CoA with 3 malonyl-CoA units . Orsellinic acid is then prenylated by the prenyltransferase ascA to yield ilicicolinic acid B . Ilicicolinic acid B is further reduced to ilicicolin B by the reductase ascB . The halogenase ascD then chlorinates ilicicolin B to produce ilicicolin A which is converted to ilicicolin A epoxide by the cytochrome P450 monooxygenase ascE that catalyzes stereoselective epoxidation of the terminal double bond of the prenyl group . Ilicicolin A epoxide is the last common precursor for the biosynthesis of ascofuranone and ascochlorin . The terpene cyclase ascF produces a monocyclic terpene, and the cyclization reaction is proposed to be initiated by protonation of the terminal epoxide of ilicicolin A epoxide to generate a monocyclic tertiarycation, which is followed by a series of hydride and methyl shifts with abstraction of proton, leading to the formation of the (14S,15R,19R)-trimethylcyclohexanone ring structure of ilicicolin C, which is finally reduced to ascochlorin by the dehydrogenase ascG . On the other hand, ilicicolin A epoxide is hydroxylated by the cytochrome P450 monooxygenase ascH, and the resultant product is cyclized by the terpene cyclase ascI to ascofuranol via protonation-initiated epoxide ring opening, which facilitates the 6-endo-tet cyclization to form the tetrahy-drofuran ring . Finally, ascofuranol is oxidized into ascofuranone by ascJ .
A0A455R413
Q65QH0
GLPE_MANSM
Thiosulfate sulfurtransferase GlpE
Basfia
MFKEITPQQAWQLMIEENATLVDIRDEQRFTYSHAKGAFHLTGQSYGKFQIQCDFDDPVIVSCYHGISSRNVAAFLVEQGYDNIYSIIGGFEGWQRAGLPIETAY
Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.
Q65QH0
Q48UH5
Y517_STRPM
Nucleotide-binding protein M28_Spy0517
Streptococcus
MSDKHINLVIVTGMSGAGKTVAIQSFEDLGYFTIDNMPPALVPKFLELIEQTNENRRVALVVDMRSRLFFKEINSTLDSIESNPSIDFRILFLDATDGELVSRYKETRRSHPLAADGRVLDGIRLERELLSPLKSMSQHVVDTTKLTPRQLRKTISDQFSEGSNQASFRIEVMSFGFKYGLPLDADLVFDVRFLPNPYYKVELREKTGLDEDVFNYVMSHPESEVFYKHLLNLIVPILPAYQKEGKSVLTVAIGCTGGQHRSVAFAHCLAESLATDWSVNESHRDQNRRKETVNRS
Displays ATPase and GTPase activities.
Q48UH5
Q8A498
IF1_BACTN
Translation initiation factor IF-1
Bacteroides
MAKQSAIEQDGVIVEALSNAMFRVELENGHEITAHISGKMRMHYIKILPGDKVRVEMSPYDLSKGRIVFRYK
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Q8A498
A0A1V0QSE8
ERIJ_HERER
Erinacine biosynthesis cluster protein J
Hericium
MSTQNYHIVAVPPNEWGHMRPMIAFLARLVAVSLNSVDITVTLIIAESAVAKARTELSIQLAGEGIQSAESRFEVVPTAVHMFWPADAYLPALKATYAEVIKKKEPDFALLESMIHPFFDVVRSSATKPIKVGAWLPVALPSWTSMAPICYIRDDPQAYVKQVETTMAEKGLGYMEAASDAYLSHVNGRVLRIPGFPEMTDYEGFPQEPPVLLPVAMVVDWVFGIRDADILVTSTAQALERQGLQVFSKWLKEQPKHSDILAVGPLTSQRTPEVARKEKEEADAGGFTAFLDAWAAKKGPKSVLYICFGSVLLPAEIEHLYAVMRVLLELQIPFIMVLSDAARAALPADLAAAVRDSGLVKLTPWAPQQYILAHAAVGWFLSHCGINGTLESLCLRVPMVCWPLFADQPVLSILVAQVYGCGYELGEVRKGFGLKYRASTGKTPGGTVEDVTREAREVFSKAFFNKAERAKVDANLEKMATELNAAWDAEGDARASALALLDFIRK
UDP-glycosyltransferase; part of the gene cluster that mediates the biosynthesis of erinacines, cyathane-xylosides that show unique biological activities, including leishmanicidal activity, stimulating activity for nerve growth-factor synthesis, and agonistic activity toward the kappa opioid receptor . The geranylgeranyl diphosphate (GGPP) synthase eriE catalyzes the first step in erinacines biosynthesis via conversion of farnesyl pyrophosphate and isopentyl pyrophosphate into geranylgeranyl pyrophosphate (GGPP) . GGPP is then substrate of the diterpene cyclase eriG for the production of cyatha-3,12-diene . EriG is unable to use geranyl diphosphate (GPP) or farnesyl diphosphate (FPP) as substrates . The cytochrome P450 monooxygenase eriI then hydroxylates cyatha-3,12-diene at C-14 of the seven-membered ring to produce erinacol, which is further hydroxylated at C-15 by the cytochrome P450 monooxygenase eriC to yield cyathadiol . The cytochrome P450 monooxygenase eriA then catalyzes C-11 hydroxylation in the presence of the short chain dehydrogenase/reductase (SDR) eriH, which leads to the production of cyathatriol . The acetyltransferase eriL converts cyathatriol into 11-O-acetyl-cyathatriol . The SDR eriH catalyzes further oxidation of 11-O-acetyl-cyathatriol into 1-O-acetylcyathin A3 . Finally, the glycosyl transferase eriJ tranfers xylose from UDP-xylose onto C-14 of 11-O-acetyl-cyathatriol to form eracine Q . EriJ is also able to convert 11-O-acetyl-cyathatriol to eracine Q2 by using UDP-D-glucose as cosubstrate, but at a lower rate . In the absence of eriL and eriJ, the SDR eriH is able to convert cyathatriol to cyathin A3; this is likely a switching mechanism in the biosynthesis of cyathins (C-14 ketogroup)and erinacines (C-14 glycosylated group) . The roles of the SDR eriB, the polyprenyl transferase eriF and the dehydrogenase eriK have still to be identified (Probable).
A0A1V0QSE8
P00296
PLAS_SOLTU
Plastocyanin
Solanum
LDVLLGGDDGSLAFIPGNFSVSAGEKITFKNNAGFPHNVVFDEDEIPAGVDASKISMAEEDLLNAAGETYSVTLSEKGTYTFYCAPHQGAGMVGKVTVN
Participates in electron transfer between P700 and the cytochrome b6-f complex in photosystem I.
P00296
Q8Y626
TYSY_LISMO
Thymidylate synthase
Listeria
MKQYLDLEKYVLENGTQKGDRTGTGTISTFGYQMRFDLQEGFPIMTTKRVPFKLVVSELLWFLHGDTNIRYLLQHNNNIWNEWAFERFVKSDDYKGEDMTDFGLRAERDPAFKEVYQAEMEKFKTRIIEDEAFATKYGELGNIYGKQWREWKTSQGETIDQLADLIEMIKTNPNSRRLIVSAWNPEDIPNMALPPCHSLFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTHLIAREVGLDVGEFIHTMGDAHLYNNHIEQVKEQLSRTPHALPKLVLSDKPATIFDFEVADISLDGYNPDPSIKAPISV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q8Y626
A4SXR0
LEU1_POLAQ
Alpha-isopropylmalate synthase
Polynucleobacter
MSDKVIIFDTTLRDGEQSPGASMTKDEKVRIARQLERLKVDVIEAGFAASSEGDFQAISAVAAAVKDSIVCSLARANDKDITRAADALQAANAKRIHAFLATSPLHMAVKLRMSPEEVLEQAKRSIRFARNLASDIEFSAEDGYRSEMDFLCRVVEAVINEGASTINIPDTVGYATPELYGDFIKTLRTRVPNSDKAVWSVHCHNDLGMAVANSLAGVKIGGARQIECTINGLGERAGNTALEEIVMALRTRKDYFDMVCGIDASQIVPASKLVSQITGFVVQPNKAVVGANAFAHTSGIHQDGILKNRDTYEIMRAEDVGWSANKIVLGKLSGRNAFKQRLQELGITVEAEADLNEAFTRFKALADQKSEIFDEDIIAIMSDSAAAEEGEHYHFISLSQHSETGERPKSRVIFRMGDKEVSSEAEGNGPVDASLNAIEEIAKSGAEQLLYSVNAITSGTQSQGEVTVRLSKGGRIVNGVGTDPDIIAASAKAYLSALNKLHDPSQAKLNAQMAP
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
A4SXR0
B8HGW7
MRAY_PSECP
UDP-MurNAc-pentapeptide phosphotransferase
Pseudarthrobacter
MIALLIGAGLALLCALVGTPLFIRLLVRRGYGQFIRDDGPTSHHTKRGTPTMGGTVVVAAVLLSYGLTHLIMFLMNPDSPGPSASALILLFLMVGMGLVGFLDDFIKISRQRSLGLNAKAKLILQAAVGVIFAVLALNFPDESGLAPASTKISLVRDLPWLDLAFGGTVLGAILFVVWSNLIVTAATNGVNLTDGLDGLAAGASVMVFGAYTLMGIWQSNQACGSPREAGSGCYSVRDPLDLALLAAIMSAALVGFLWWNTSPAKIFMGDTGSLAIGGAIAGFAILSRTELLLGIIGGLFVLITLSVIIQVGYFKATGGKRVFKMAPLQHHFELKGWAEVTVVVRFWILGGLFVAVGLGIFYAEWVVLL
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
B8HGW7
P39076
TCPB_YEAST
CCT-beta
Saccharomyces
MSVQIFGDQVTEERAENARLSAFVGAIAVGDLVKSTLGPKGMDKLLQSASSNTCMVTNDGATILKSIPLDNPAAKVLVNISKVQDDEVGDGTTSVTVLSAELLREAEKLIDQSKIHPQTIIEGYRLASAAALDALTKAAVDNSHDKTMFREDLIHIAKTTLSSKILSQDKDHFAELATNAILRLKGSTNLEHIQIIKILGGKLSDSFLDEGFILAKKFGNNQPKRIENAKILIANTTLDTDKVKIFGTKFKVDSTAKLAQLEKAEREKMKNKIAKISKFGINTFINRQLIYDYPEQLFTDLGINSIEHADFEGVERLALVTGGEVVSTFDEPSKCKLGECDVIEEIMLGEQPFLKFSGCKAGEACTIVLRGATDQTLDEAERSLHDALSVLSQTTKETRTVLGGGCAEMVMSKAVDTEAQNIDGKKSLAVEAFARALRQLPTILADNAGFDSSELVSKLRSSIYNGISTSGLDLNNGTIADMRQLGIVESYKLKRAVVSSASEAAEVLLRVDNIIRARPRTANRQHM
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.
P39076
A8GPF2
EFTU_RICAH
Elongation factor Tu
spotted fever group
MAKAKFERTKPHVNIGTIGHVDHGKTSLTAAITTVLAKTGGAKATAYDQIDAAPEEKERGITISTAHVEYETKNRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSAADGPMLQTREHILLAKQVGVPAMVVFLNKVDVVDDPALLELVEMEVRDLLLQYGFPAYEVPIIKGSALQALAGKPEGEKAINELMDAVDNYIPHPVRATDKPFLMPIEDVFSISGRGTVVTGRVESGIIKVGEEVEIVGLKETQKTTCTGVEMFRKLLDEGQAGDNVGILLRGTKREEVERGQVLAKPGSIKPHDQFEAEVYVLSKEEGGRHTPFTNDYRPQFYFRTTDVTGTIKLPADKQMVMPGDNATTFTVELIKPIAMQQGSKFSIREGGKTVGAGVVTKINN
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
A8GPF2
Q8FHG6
GADC_ECOL6
Glutamate/gamma-aminobutyrate antiporter
Escherichia
MATSVQTGKAKQLTLLGFFAITASMVMAVYEYPTFATSGFSLVFFLLLGGILWFIPVGLCAAEMATVDGWEEGGVFAWVSNTLGPRWGFAAISFGYLQIAIGFIPMLYFVLGALSYILKWPALNEDPITKTIAALIILWALALTQFGGTKYTARIAKVGFFAGILLPAFILIALAAIYLHSGAPVAIEMDSKTFFPDFSKVGTLVVFVAFILSYMGVEASATHVNEMSNPGRDYPLAMLLLMVAAICLSSVGGLSIAMVIPGNEINLSAGVMQTFTVLMSHVAPEIEWTVRVISALLLLGVLAEIASWIVGPSRGMYVTAQKNLLPAAFAKMNKNGVPVTLVISQLVITSIALIILTNTGGGNNMSFLIALALTVVIYLCAYFMLFIGYIVLVLKHPDLKRTFNIPGGKGVKLVVAIVGLLTSIMAFIVSFLPPDNIQGDSTDMYVELLVVSFLVVLALPFILYAVHDRKSKANTGVTLEPINSQNAPKGHFFLHPRARSPHYIVMNDKKH
Involved in glutaminase-dependent acid resistance. Exchanges extracellular glutamate (Glu) for intracellular gamma-aminobutyric acid (GABA) under acidic conditions. The ability to survive the extremely acidic conditions of the stomach is essential for successful colonization of the host by commensal and pathogenic bacteria.
Q8FHG6
Q26516
PPIE_SCHJA
Rotamase E
Schistosoma
EDVSDDEMRTKKQKRNLPRVFFDIRIGNADRGRIVMELRSDIVPRTAENFRALCTGDRGFGYHNCCFHRVIPQFMCQGGDFVKGDGTGGKSIYGRKFDDENFQLRHEGFGVLSMANSGPNTNGSQFFICTTKCDWLDGKHVVFGRVVDGQNVVKKMESVGSKSGKVKEPVTISRCGELI
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Q26516
O19015
BGAL_FELCA
Acid beta-galactosidase
Felis
MDFPGAARLLSLLLVPLLLGPARGLRNASQRTFKIDYGHNRFLKDGQPFRYISGSIHYFRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPQPGQYQFSGEHDVEYFLKLAHELGLLVILRPGPYICAEWDMGGLPAWLLLKESIILRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPIITVQVENEYGSYFTCDYDYLRFLQRRFRDHLGGDVLLFTTDGAHEKFLQCGALQGIYATVDFGPDANITAAFQIQRKSEPRGPLVNSEFYTGWLDHWGQPHSRVRTEVVASSLHDVLAHGANVNLYMFIGGTNFAYWNGANIPYQPQPTSYDYDAPLSEAGDLTDKYFALRDVIRKFEKVPEGFIPPSTPKFAYGKVALQKLKTVEDALNVLCPAGPIKSLYPLTFIQVKQYFGFVLYRTTLPQDCSNPTPLSSPLNGVRDRAYVAVDGVPQGVLERSYVITLNITGQAGATLDLLVENMGRVNYGRYINDFKGLISNLTLGSSVLTDWMIFPLDTEDAVRSHLGGWHGRNHGRQDNKAFAHHSSNYTLPAFYAGNFSIPSGIPDLPQDTFIQFSGWTKGQVWINGFNLGRYWPGRGPQVTLFVPRHILVTSAPNTIMVLELERAPCDDNGPELCTVEFVDRPLISATPTSSHPLPDLSDRDSGWDRV
Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
O19015
Q9GLM4
TENS1_BOVIN
Tensin-1
Bos
MSTSRTTEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSERRPDITKLHAKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADHALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKGGCRPFLRIYQAMQPVYTSGIYNVQGDSQTSICITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDYNTSDPLIRWHSYDNFNGHRDDGMEEVVGHTPGTLDGSLYAKVKKKDSLHGSNGAVNATRPVLSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPAPGPASAPAALSPEEKRELDRLLSGFGLEREKQGAMYHPQHLRSRPVGGPAAPSSGRHIVPAQVHVRGGVLSVERETDILDDELPNQDGHSVGSMGTLSSLDGVTNTSEGGYPEALSPLTNGLDKPYPMEPMVNGGGYPYESASRAVSAQAGHTAPMRPSYSTQEGLAGYQREGPHPAWPQSATTSHYGHDPNGMFRSQSFPETEPQLPPAPARGGSSREAVQRGLNSWQQQQQQQQQQQQPRPPPRQQERVHLESLGLSRPSPQPLAEPPMSGLPEFPRAASQQEIEQSIEALNMLMLDLEPATAGAPLHKSQSVPGAWPGASPLSSQPFSGSSCQSHPLTQSRSGYIPSGHSLGTPEPAPRAPLESVPTGRPYSPYDYQPCPTGPNQSYHPKSPATSSSSSFLPTTQSSVGPQQPPASLPGLTTQPQLPPKEVTSDPSRTPEEEPLNLEGLVAHRVAGVQAREKQPAEPPAPLRKRAASDGQYENQSPEPTSPRSPGVRSPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTSPTSPPPSGVRSPPGLAKTPLSALGLKPHNPADILLHPTGEPRSYVESVVRTAVAGPRTQEPEPKSFSAPAAQAYGHETPLRIGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGARTPTQPLLDSGFRSGSLGQPSPLAQRNYQSSSPLPTAGSSYSSPDYSLQQFSSPEGQARSQFSVAGVHTVPGSPQARHRTVGTNTPPSPGFGRRAVNPSLAAPSSPSLSHRQVMGPLGTGFHGNTGSSPQSSAATTPGSPSLGRHPGAQVSNLHGNVVTRPGSPSLGRHPGAHQGTLASNLHSNAVASPGSPSLGRHLGGSGSVVPGSPSLDRHVPYGGYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSMGDRAGSLPNYATVNGKVSSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMPDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTSDLLKQGAACNVLFVNSVDMESLTGPQAISKAISETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWTKTEGGAPAKLFGFVARKQGSATDNACHLFAELDPNQPASAIVSFVSKVMLSAGQKR
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Q9GLM4