accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q1BYH4
UREF_BURCA
Urease accessory protein UreF
Burkholderia cepacia complex
MTTTELVALLHLASPALPIGAYSYSQGLEAALDANLIRDADSARDWIASGLTDVLAHGELPFLAHQLARWQTHDTHALAAENAWFVASRESAELRRETEQMGWSLAQLCASLEWGDAARRATLASLSPIALPTAFAYAAAAHDAGADATLAAYAFGWVENQTSAALKAVPLGQLAGQRIIVALRGAIDAAVRRALATPPDAVNTFAPQLGILSARHETQYSRLFRS
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Q1BYH4
A7INK7
TPIS_XANP2
Triose-phosphate isomerase
Xanthobacter
MPASRRVLIAGNWKMNGLKSSLAEIEALAAGYDGDLKAKLDLLVCPPATLLISAAERLAGSGVQLGGQNCHPAPAGAHTGGISAEMLKDAGVTSVIVGHSERRTNLSESDAVVMAKVKAAWCFGLLPIVCVGETAEERDAGEAVGVVTRQVHQSLPEGCTASNLVIAYEPVWAIGTGRTPTPEDVANIHGTIRSVLRSQFGAEADGIRILYGGSVKPDNAATLMAVADVDGALVGGASLKAADFLAIARATPAR
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
A7INK7
Q2TL60
ZN667_MOUSE
Myocardial ischemic preconditioning up-regulated protein 1
Mus
MPAVRGKSKSKAPVTFGDLAIYFSQEEWEWLSPMQKDLYEDVMLENYHNLVSVGLACRRPNIIALLEKGKAPWVIEPSRRRWGPESGSKYETKKLPPNSCHKSGPSICEKPTSSQQKVPTEKAKHNKSSVPSKSKKEHSGKKSLKCNLCGKTFFRSLSLKLHQDFHTGERSYECSTCRHVFRQILSLILHQRVHNWNKSYECDKCGDIFNKKLTLMIHRRIHNGKESFHHEKASDSCPSLSLHRNNHTTDSVHQCRKCGKVFSRMSSLLLHKRSHNRKKIQKYNKYKRGFKKQPVLVHKRVCIGKKTHESKKALIQSARQKTCQSENPFMCGKCGKSFSRISALMLHQRIHTSGNPYKCDKCQKDFGRLSTLILHLRIHSGEKQFKCSKCEKVCSRLSSFIQHQKIHKRKKKLIACKECGKMFGGMKNLKVHLNIHSEEKPFKCNKCSKVFGRQSFLSEHQRIHTGEKPYQCEECGKAFSHRISLTRHKRIHSEDRPYECDLCGKAFSQSAHLAQHERIHTGEKPYACKICKKSFAQRISLILHERSHTGERPYECNECGKAFSSGSDLIRHQRSHSSEKPYECSKCGKAYSRSSSLIRHQSIHSEETP
May be involved in transcriptional regulation.
Q2TL60
Q7VDG6
YIDD_PROMA
Putative membrane protein insertion efficiency factor
Prochlorococcus
MIKKINAVISNLFLTLIRFYRSWISPLLGPSCRFVPTCSEYGVEAIEKHGPWKGGWLTLKRLLRCNPLTPCGYDPVPDK
Could be involved in insertion of integral membrane proteins into the membrane.
Q7VDG6
A9MAR7
TRMFO_BRUC2
Folate-dependent tRNA(M-5-U54)-methyltransferase
Brucella
MSNNTDLSPVHVIGGGLAGSEAAWQIAQAGVPVVLHEMRPVRGTDAHKTEQLAELVCSNSFRSDDAETNAVGVLHAEMRLAGSLIMACADAHQVPAGGALAVDREGFSQAVTARLEAHPLITIEREEITGLPPTEWGTTIIATGPLTAPSLAEAIAAETDADALAFFDAIAPIIHFDSINMDVCWFQSRYDKVGPGGTGKDYINCPMDEEQYEAFVAALIEGDKTDFKEWEGTPYFDGCLPIEVMAERGPETLRHGPMKPMGLTNAHNPTVKPYAVVQLRQDNALGTLYNMVGFQTKLKYGSQTGIFKMIPGLENAEFARLGGLHRNTYLNSPVLLDNVLRLKSRQTLRFAGQVTGCEGYVESSAIGLLAGRFTAAEKLSQAAVPPPPTTAFGALLGHITGGHIVTDDEPGKRSFQPMNVNFGLFPPVDVPKPEGKRLRGKEKTIAKKRALSARALADCRNWLSLY
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
A9MAR7
Q9BRT2
UQCC2_HUMAN
Mitochondrial protein M19
Homo
MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSLEEYKLILSTDTLEELKEIDKGMWKKLQEKFAPKGPEEDHKA
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability.
Q9BRT2
Q7M722
TR114_MOUSE
Taste receptor type 2 member 114
Mus
MLSTMEGVLLSVSTSEAVLGIVGNTFIALVNCMDYNRNKKLSNIGFILTGLAISRICLVLILITEAYIKIFYPQLLSPVNIIELISYLWIIICQLNVWFATSLSIFYFLKIANFSHYIFVWLKRRIDLVFFFLIGCLLISWLFSFPVVAKMVKDNKMLYINTSWQIHMKKSELIINYVFTNGGVFLFFMIMLIVCFLLIISLWRHRRQMESNKLGFRDLNTEVHVRTIKVLLSFIILFILHFMGITINVICLLIPESNLLFMFGLTTAFIYPGCHSLILILANSRLKQCSVMILQLLKCCENGKELRDT
Putative taste receptor which may play a role in the perception of bitterness.
Q7M722
A8QL53
VSP1_NAJAT
Snake venom serine protease NaSP
Naja
MVLIRVLASLLILQLSYSKSLDDGAKESAYDDEIQQSSWGNSTVNTTLTETVVIQLIMGGSECYKSKHPFLVYLYNSAGFFCSGTLLNHEWVLTAAHCNRDDIQLKLGVHNVHVHYEDEQIRVPKEKLCCLSTKNCTQWSQDIMLIRLNSSVNNSKHIEPLSLPSRPPSMGSDCTVMGWGTITSPKVTYPKVPHCVDIKILHNPVCQAAYPTMSRKNILCAGVLEGGKDSCKGDSGGPLICDGQIQGIVSWGRFPCAQLLEPGVYTKVFDYIDWIRGIIAGN
Snake venom serine protease that may act in the hemostasis system of the prey.
A8QL53
P30739
TNPT_PSEPU
Resolvase/recombinase
Pseudomonas
MRLFGYARVSTSQQSLDVQIKALKAENVRATRIFTDKVSGSHVNREGLRMLRLKVEEGDVVLVKKLDRLGRDTADMIQLIKEFDDMGVAIRFLDDGISTEGTMGKMVVTILSAVAQAERLRILERTNEGRLEAKAKGVKFGRKPTVDKAEVFTLHGQGISAMEIAKRLKIGRSTVYKVLAS
Site-specific recombination protein.
P30739
O95847
UCP4_HUMAN
Solute carrier family 25 member 27
Homo
MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSGVSPF
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. May play a role in thermoregulatory heat production and metabolism in brain.
O95847
Q96PF2
TSSK2_HUMAN
Serine/threonine-protein kinase 22B
Homo
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.
Q96PF2
A9N9F4
UBIE_COXBR
Demethylmenaquinone methyltransferase
Coxiella
MNETEKSTHFGYQTVPTDQKTDKVKHVFESVAAKYDLMNDLMSLGIHRCWKDFAITQCRLRTGQRILDLAGGTGDLAKRISPLVGDEGEVVIADINAAMLNVGRRRLLDQGIFRNIQFIQADAEKLPFPNNFFDRIVIGFGLRNVTNQLAALQSMHRVIKPGGFVVILEFSKPTLAPLKAVYDAYSFQLLPRLGKLVAKDEESYRYLVESIRMHPDQEALLSKMTDAGFEDCDYHNLSGGIVAVHRGYKF
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
A9N9F4
Q5PI73
TREA_SALPA
Alpha,alpha-trehalose glucohydrolase
Salmonella
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLFPDQKTFADAIPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRFREIYYWDSYFTMLGLAESGHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMVELLAQHEGDDALKEYLPQLQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAKASQYDALANARQKAIEMHLWNNKEGWYADYDLQNNKIRDQLTAAALFPLYVNAAAKDRAVKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVAMEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSATPTKTPSAATQ
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
Q5PI73
Q9Y397
ZDHC9_HUMAN
Zinc finger protein 380
Homo
MSVMVVRKKVTRKWEKLPGRNTFCCDGRVMMARQKGIFYLTLFLILGTCTLFFAFECRYLAVQLSPAIPVFAAMLFLFSMATLLRTSFSDPGVIPRALPDEAAFIEMEIEATNGAVPQGQRPPPRIKNFQINNQIVKLKYCYTCKIFRPPRASHCSICDNCVERFDHHCPWVGNCVGKRNYRYFYLFILSLSLLTIYVFAFNIVYVALKSLKIGFLETLKETPGTVLEVLICFFTLWSVVGLTGFHTFLVALNQTTNEDIKGSWTGKNRVQNPYSHGNIVKNCCEVLCGPLPPSVLDRRGILPLEESGSRPPSTQETSSSLLPQSPAPTEHLNSNEMPEDSSTPEEMPPPEPPEPPQEAAEAEK
(Microbial infection) Through a sequential action with ZDHHC20, rapidly and efficiently palmitoylates SARS coronavirus-2/SARS-CoV-2 spike protein following its synthesis in the endoplasmic reticulum (ER). In the infected cell, promotes spike biogenesis by protecting it from premature ER degradation, increases half-life and controls the lipid organization of its immediate membrane environment. Once the virus has formed, spike palmitoylation controls fusion with the target cell.
Q9Y397
Q1I4H6
THIE_PSEE4
Thiamine-phosphate pyrophosphorylase
Pseudomonas
MTLRGLYAITDSQLLAGRFLSHVEAALEGGVCLLQYRDKSDDAGRRLREAEGLKKLCERYGTQLIINDDAELAARLGVGVHLGQTDGPLTPARALLGRQAIIGSTCHASLELAEQAASEGASYVAFGRFFNSVTKPGAPAASLELLEQARARVKLPIAVIGGITLDNAAPLVAHGADLLAVIHGLFGADSAQEVTRRARAFNALFAS
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Q1I4H6
A0M672
UVRC_GRAFK
Excinuclease ABC subunit C
Gramella
MEKPALEVQLKTLPNSPGVYQYFDKNGKILYVGKAKNLKKRVTSYFNKNHDSHRIGVMVKKICEIKHIVVASETDALLLENNLIKKHQPRFNVMLKDDKTYPWICIKNERFPRVFPTRRLIKDGSEYYGPFTSFKTVNTLLDLIKGLYKLRTCNYDLAEDKIRNGKYKVCLEYHLGNCLGPCEGFQPEEEYNNNIEAIRQIVKGNFKDSLQRFRNQMKQHSEKMEFEDAQRIKNKIDVLENYQAKSTVVNPRINNVDVFSVVSDEGYGYVNFLQLSHGAIIRSHTIEMKKKLDESDRELLELAIVEIRQRFSSNSTEIYVPFKVDVGEELKIVIPKLGDKKKIVELSQRNAKYFRQERFKQMKIVDPDRHVNRVMAQMKEDLRLGKEPRHIECFDNSNIQGTNPVAACVVFKNGKPSKKDYRKFNIKTVEGPDDFASMEEVVFRRYRRLLNEGEDLPELIIVDGGKGQLSSGVKALETLGLRGKIAIIGIAKRLEEIFYPEDSIPLYLDKKSETLKIIQQLRNEAHRFGITFHRNKRSKTALNTELESIQGIGEKTVVELLTHFRSLKRIKEASQKELADVVGSAKAAIICNFYHSE
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A0M672
Q8EBZ8
YQGF_SHEON
Putative pre-16S rRNA nuclease
Shewanella
MNAKTVLGFDFGTKSIGVAVGQQITASATPLLSIKAVDGIPNWEEIAKLIQEWQPDLVVVGLPLNMDGTEQEMTHRARKFANRLNAKFGVKIFTQDERLTTTDAKARLFELGGYKALTKGQVDAVSAVLIIESYFENHFGD
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Q8EBZ8
Q14IB6
TDH_FRAT1
L-threonine 3-dehydrogenase
Francisella
MKALAKLKKQPGIWIINDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPMITGHEFAGEVVAKGDGVTSVDIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQGAFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALSFNLTGEDVLITGAGPIGLMAVKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTEGFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREMFETWYLMTSMLQAGMDMNPIITHRLHIDEFQKGFEIMKSGQCGKVILDWSS
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
Q14IB6
P21609
THIO_PEPLI
Thioredoxin
Peptoclostridium
MLMLDKDTFKTEVLEGTGYVLVDYFSDGCVPCKALMPAVEELSKKYEGRVVFAKLNTTGARRLAISQKILGLPTLSLYKDGVKVDEVTKDDATIENIEAMVEEHISK
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
P21609
P76500
YFCQ_ECOLI
Uncharacterized fimbrial-like protein YfcQ
Escherichia
MRKTFLTLLCVSSAIAHAADEDITFHGTLLSPPTCSISGGKTIEVEFRDLIIDDINGNYGRKEVPYELTCDSTTRHPDWEMTLTWTGTQTSFNDAAIETDVPGFGIELQHDGQRFKLNTPLAINATDFTQKPKLEAVPVKASDAVLSDTNFSAYATLRVDYQ
Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
P76500
Q8EGF9
TILS_SHEON
tRNA(Ile)-lysidine synthetase
Shewanella
MTAQDLSVHIARWLDSLPLQAGSKLVLAYSGGVDSEVLAYGLSEYAKQRPDLRYQLIYVHHGLSPNADNWAKHCQARAAIYGLPVTVERVQLILGPRVSVEAEARKARYQAILPHLNPQDILLTAHHEDDQLETILLALKRGQGPKGLAAMGQIQPLSLADKGSCLQVRPLLDISREMIETFAQTRQLVHIEDESNQDDKYDRNFLRLEIIPRLKARWPSIATTASRSAQLCAEQQAIVETEVSERLPKLLVKAPVTEQTVLKLSELAAQPIEWQGILLRGFIESQEFSLPSYVQLQQMLQQLIHAKEDAKVHIRINDCVLRRFAGMLYLDSGETLSTALHITARDLHQEILTLLTQASAMVEDKIVPFALVTTGPRLRLPKADEVVSLGYGLPGQFRCQPHFRDKGRELKKLWQECAVPPWLRAEVGFLFYNDKLVMAFGLWVEKAFCAQGDEIGLSYLIANP
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Q8EGF9
A4IF63
TRIM2_BOVIN
RING-type E3 ubiquitin transferase TRIM2
Bos
MASEATNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRSPGSSAEESSILETVTAVAAGKPLSCPNHDGNVMDFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAANRRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLEGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIVTDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ
E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
A4IF63
A9W297
UREG2_METEP
Urease accessory protein UreG 2
Methylorubrum
MKKITRIGIGGPVGSGKTAVIETITPRLIALGIKPLIITNDVVTTEDAKQVRRTLHGVLIEEKIVGVETGACPHTAVREDPSMNIAAVEELEDKYPDSDVILIESGGDNLTLTFSPALADFYIYVIDVAAGDKIPRKNGAGVCQSDILVINKKDLAPYVGASLEVMARDSKLMRGKKPFLFTNCKTGEGVDDLLQLILDMALFDVRTRPPLAASA
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
A9W297
Q05589
UROK_BOVIN
Urokinase-type plasminogen activator chain B
Bos
MRVLLACLLVCALVVSDSDGSNEVHKESGESNCGCLNGGKCVTYKYFSNIQRCSCPKKFQGEHCEIDTSKTCYQGNGHSYRGKANRDLSGRPCLAWDSPTVLLKMYHAHRSDAIQLGLGKHNYCRNPDNQRRPWCYVQIGLKQFVQFCMVQDCSVGKSPSSPREKEEFQCGQKALRPRFKIVGGQVTNAENQPWFAAIYRRHRGGSITYLCGGSLISPCWVVSATHCFIDHPKKENYIVYLGQSRLNSDTRGEMQFEVEKLILHEDYSAESLAHHNDIALLKIRTSRGQCAQPSRSIQTICLPPEHEDAHSRTRCEITGFGKENPSDYRYSDELKMTFVSLVSHEVCQQPHYYGAEVTDKMLCAADPQWETDSCQGDSGGPLVCTIQGRLTLTGIVSWGRDCAMKYKPGVYTRVSKFLPWINTHTRGEINLVL
Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.
Q05589
Q9NEZ5
UNC95_CAEEL
LIM domain-containing protein unc-95
Caenorhabditis
MTISPQPSHQQFESYQWTTESRSSQQRHGTGTPSQDGRLSAIPDPVERHVARWRSESRNSNKDKVFRNDEEFSQQDEIVNGTLTALKNDVEQTTEIIRRKQEQMRMERRQFQTEMEVNGRISIDPTDDWLAARLKAVSSDDMNQQLVKLKQDQRQNAVTDTLAALVYDVNATTEVLRRGQRGRDGEDGNKKKKEEIEYTLRLTPAPEEQIPQRPKIPEDDNMETDDYSRQYGVQMSEETDSLRRRRARSTTPRRTLHISGSPPPPAAAVCAYCSEEIDGAILTALAPNSERAQKFHTYHFMCTYCQKALNMHGTYREHDLKPYCHDCFYKLYNGLQYAPDDHQASIEKLI
Required for the assembly and integrity of muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix . Decreased localization of unc-95 to dense bodies and their subsequent dissociation plays an important role in ecdysis during molting . Involved in the organization of the muscle sarcomeric structure and thereby required for locomotion .
Q9NEZ5
Q1D6I2
TRMD_MYXXD
tRNA [GM37] methyltransferase
Myxococcus
MSPPYPVEILTLFPGMVTGYLGASILGKAQEKGLLATTITDIREYAEGKHRVTDDAPYGGGAGMVMKPEPLVAAIEAAKARHPGARVLLMSPRGPTFTQATARELVRHEAGLILVCGRYEGVDERVMAHLDGELSLGDFVLTGGELAAMTVVDAVARLVPGVLGNVDSSVTESFEEGLLEHPQYTRPPVFRGVEVPAALQSGDHARIARWRRWKSLVLTHERRPDLYARVVLSKADQKLLARREEEL
Specifically methylates guanosine-37 in various tRNAs.
Q1D6I2
Q9LUN2
YSL5_ARATH
Protein YELLOW STRIPE LIKE 5
Arabidopsis
MRKGVLNPDRDRQIVEHELQETGFSPETEKVKNKNFEEDEEEEDESVEKIFESREVPSWKKQLTVRAFVVSFMLSILFSFIVMKLNLTTGIIPSLNVSAGLLGFFFVKTWTKMLHRSGLLKQPFTRQENTVIQTCVVASSGIAFSGGFGTYLFGMSERIATQSGDVSRGVKDPSLGWIIGFLFVVSFLGLFSVVPLRKIMVIDFKLTYPSGTATAHLINSFHTPQGAKLAKKQVRVLGKFFSLSFFWSFFQWFFTGGENCGFSNFPTFGLKAYQYKFYFDFSATYVGVGMICPYIINISVLLGGILSWGIMWPLIETKKGDWFPDNVPSSSMHGLQAYKVFIAVAIILGDGLYNFCKVLSRTLSGLFVQLRGPTTSISRTSFTLEEDPHASPLSPKQSYDDQRRTRFFLKDQIPTWFAVGGYITIAATSTAILPHMFHQLRWYYILVIYICAPVLAFCNAYGAGLTDWSLASTYGKLAIFTIGAWAGSEHGGMLAGLAACGVMMNIVSTASDLTQDFKTGYLTLSSPKSMFVSQVIGTAMGCVVSPCVFWLFYKAFDDLGLPNTEYPAPFATVYRSMAKLGVEGVASLPRECLVLCYAFFGVAILVNIVKDSLHSNWGRFIPLPMAMAIPFFLGPYFAIDMCVGSLILFIWERVDAAKAEAFGTAVASGLICGDGIWSLPSSVLAIAGVNPPVCMKFLSSATNSKVDNFLKGSI
May be involved in the transport of nicotianamine-chelated metals.
Q9LUN2
P38951
XEN2_XENLA
Xenoxin-2
Xenopus
LKCVNLQANGIKMTQECAKEDNKCLTLRSLKKTLKFCASDRICKTMKIMSLPGEKITCCEGNMCNA
Lacks alpha-neurotoxic activity, has apparently no antibacterial activity, nor anti-coagulant potency.
P38951
A9IYI2
TILS_BART1
tRNA(Ile)-lysidine synthetase
Bartonella
MCVRLARNLFKTSDFIPCRRVILAVSGGSDSLALMFLVKEYLETLLIPPEIIAVTVDHQLRKESAREAEIVAEICRDHHIKHITVRWEGKKPKTHLAFSARIARYDLLVQEAQKQGASLIMTGHTLNDQVETYQMRCQRLQKRRGALRDEVGAMCDGGAASGFAGALRDKAGARRDEDYVRETRKNIAEKSYGVLYERGLSCIPREALLHRKVRLIRPLLGVQRQTLRNYLRLQGKTWIDDPTNEDRNFERVRVRQSLSSQKLVNIAQKINKAAWQRRQQAQNIADLILALDITVQYGRCFIVKPAPFLQKHSCFPFVVGLFAVLMGGGFYLLSNQKLSMLVQKLCLNSPEKRRFTCAGCVIEYNKEGIALWRERRNMKEALVEPDETLLWDGRYRITNHGSEAIKVGVANLEQLKSLLQNSNSNLEKPHFPSLQSLLMLSNDKGCDIPELISQAIIHKNVIIKRIMAPFDWLSSREDAALVNVVEPFFNLEVKR
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
A9IYI2
B5L3X1
WFED_SHIBO
null
Shigella
MIDNLIKRTPEINRLLENKRVTGVVTFVNPYSYYKIKEYNKISQLDYIYIDGILLLKLFNFVNGTKIKRHSFDYSSIAKTVFNYSIQNKMKIGLIGSKDYEIEQAVKNIRKKHPGIDISYFHSGYFSSLEEKSSVIDSVIKKSDIIICGLGTPAQEELALDIKIKSNEHLIFTCGGFFTQTASRADFYYPWIKRYNLMWLQRIVLYKHVRKRFFIDYPKFIVRFISENLMKIFTRSN
Galactosyltransferase that adds one galactose residue in the beta-1-4 linkage to GlcNAc-alpha-pyrophosphate-lipid in the biosynthesis of the O-polysaccharide repeating unit of the O antigen.
B5L3X1
O93807
TBG_CANAX
Gamma-tubulin
Candida
MPGETITLQVGQCGNQVGLQYWQQLATEHGIQSDGSSTPYPKDINDLQLQELNNSGSSPQSYPQQTKPNGKYRNDHPELFFTLSDSNTYTPRSILIDMEPSVIAKSTSALPMFNPRNVHLSNQGNGAANNWINGYKYGTEEEETLLNLIDREVDKCDNLSNFQLFHSVAGGTGSGVGSKMLEVISDRYGHKKLLNTFSIFPSNEDTSDVVVQPYNTILTLKRLIDYSDATFVFHNDSLNRIENILFNNNSNIQHDDNDLFLGANKLIALVSASVSNPLRFPGYMYSSMESIVSNLIPTPDLKFLTSSIAPFSTQKHNYLNEYDMLLELSNDRYKTNRVGGDTSYISMLNYLIGYNLDQREIRKGILKSQQRISFVPWVARSVLVVHGKKSPYLKNTNLEGIQVTNNTSMIDVFTKILKQFDLLIKRKAYLNRYYSSVEEENEVMEMFNESRESVKSIIDEYKACKEITYLDDDDEDDLEDGDGGGGGNGNGYNNIDDADMGI
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.
O93807
Q1QWC2
YIDD_CHRSD
Putative membrane protein insertion efficiency factor
Chromohalobacter
MRPGKRRPLTRLPFALLSWGMIGLLRVYQYGISPLLGPRCRFWPSCSQYAVEAIQVHGPLKGAWLALKRIVKCHPGHPGGVDPVPPGPHETPRKTSTHDDEPPSR
Could be involved in insertion of integral membrane proteins into the membrane.
Q1QWC2
Q12PE6
TOLB_SHEDO
Tol-Pal system protein TolB
Shewanella
MKILAKWLTLATLMLTAQVNAALDIVITEGVDAARPIAVVPFVWEGPGAAPQQISDIVMGDLSRSGTFKPLDIRALPQHGISSVAQFAAASWGKVGAEAVVMGSIKPYGVDQFLVNFELIDLVRAQSQALKGPQNNTELVLESRQTVISANQFRQYGHRISDIVYEKLTGIRGAFLTRTAYVVVKQGQKAPYHLMIADYDGYNEQMLLRSPEPLMSPTWSPDGRRLAYVSFENRKAEIFVQDIYSQTRTLVSSYPGINGAPSFSPDGKKLAVTLSKDGQPEVYVIDIATKAAKRITDHYSIDTEPSWYPDGKSLLFTSERGGKPQIYSVHLDTGKVSRVTFEGEWNLGGSITPDGRSMIFVNRTNGKFHIARMDLATRFLQVLSSTQLDESPSVAPNGTMVIYGTTHQGKQVLAAVSMDGRFKARLPVGQGEVKSPAWSPFL
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
Q12PE6
Q11CR0
TRMD_CHESB
tRNA [GM37] methyltransferase
unclassified Chelativorans
MTFRATVLTLYPEMFPGPLDISLAGRARSAGTWSLETVQIRDFATDKHRSVDDTPAGGGAGMVMRADVLARAIDHASPEEDARPRLLMSPRGKPLTQSFVRELATGPGAVIVCGRFEGVDQRVIEARCLLEVSVGDYILSGGEPAAIVLLDAVVRLLPGVMGNESSGAEESFESGLLEHPQYTRPQTFEGREIPEVLTSGNHRKIAEWRSAEAEQLTRERRPDLWLGYHRAKGGT
Specifically methylates guanosine-37 in various tRNAs.
Q11CR0
B7IM77
TRPA_BACC2
Tryptophan synthase alpha chain
Bacillus cereus group
MGVEKIKAAFENGKKAFIPYVMGGDGGLEKLKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEVRKEVQIPFVLMTYLNPVLAFGKERFVEKCLEAGVDGIIVPDLPYEEQNIIAPLLREANIALIPLVTVTSPIERIEKITSESEGFVYAVTVAGVTGVRQNFKEEIHSYLEKVKLHVNLPVVAGFGISTKEHVEEMVTICDGVVVGSKIIELLENEKREEICELIYATKQKEEA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
B7IM77
Q9C037
TRIM4_HUMAN
Tripartite motif-containing protein 4
Homo
MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHAMAPIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHFKQEEKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEAVKVKTVCQIPLMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVSRLRPFFWLSPLASLVIPPVTDRK
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction.
Q9C037
E7FL12
VKT2_PSERS
Kunitz serine protease inhibitor Pr-mulgin 2
Pseudechis
MSSGGLLLLLGLLTLWEGLTPVSSKDRPHFCHLPHDPGPCKGNFQAFYYHPVRRTCLEFIYGGCQGNPNNFKTIDECKRTCAA
Serine protease inhibitor that acts against trypsin (EC(50)=10 nM, Ki=5nM), chymotrypsin (EC(50)=100 nM, Ki=40 nM), and plasmin (EC(50)=100 nM, Ki=40 nM).
E7FL12
O29028
TRPB2_ARCFU
Tryptophan synthase beta chain 2
Archaeoglobus
MLSWCMKKIMLDESEMPKEWYNVLPDLPEPLPPPLHPATQEPVKPEDLEPIFPKGLIQQEMSGERWIRIPEDVREIYRIWRPTPLVRAERLEKALKTPARIYFKYEGASPPGSHKPNTAVAQAYYNAKEGVERLTTETGAGQWGSALCFATKLFEMACTVYMVKVSFMQKPYRRVMMETWGGEVIPSPSDRTEVGRKILAENPDTPGSLGIAISEAIEDAAKNENTKYSLGSVLNHVLLHQTVIGLETKAQLEKVDEKPDVLIGCVGGGSNFAGLTYPFVNDAKNGDLEIIAVEPAACPTLTAGEYKYDFGDVAGLTPLLKMYTLGHDFIPPPIHAGGLRYHGDAPTLCMLVKHGVIKARAVKQLPTFEAGLLFARTEGIIPAPETNHAVRAAIDEAIKARENNEEKVIVFGFSGHGLLDLQAYDDYLAGRLADT
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
O29028
A8GQ89
Y6705_RICAH
Nucleoid-associated protein A1C_06705
spotted fever group
MVNFNQFLKQAQSMQKKMQEAQEQMANARYTGKAGGGLVEIIITGKGEVAKISIDESLLKSEEKEMLEDLIKVAFNDAKQKCDEDSQNSLSGALNGMSLPPGFKMPF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
A8GQ89
C0M8L4
TRUA_STRE4
tRNA-uridine isomerase I
Streptococcus
MTRYKAIISYDGTLFSGFQRQSQARTVQEEIEKTLQKLTGGQGIQIHGAGRTDAGVHAYGQVIHFDLEQKRDPEKLRFALDTQTPDDIDVISLEIAADDFHARYHKHFKTYEFLVDIGRPKNPMMRHYATHYPYPLDIAKMQAAIKDLVGTHDFTGFTAAGTSVKNKVRTITAATLTQDPKTGFLVFTFSGNGFLYKQVRNMVGTLLKIGNGRLPIEQIRLVLESKNRQLAGPTAAGNGLYLKEIIYEE
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
C0M8L4
Q95ZS2
TDC1_CAEEL
Tyrosine decarboxylase
Caenorhabditis
MVYGLGEALKNLNSYCQERTTRIRNSLSPSRPSMSEATATGSSSSSRASTTIPSTPNMDVTPTVEDPRQNDNNASGMTRDEFRQYGKETVDYIVDYLENIQKRRVVPAIEPGYLKDLIPSEAPNTPESFESVMEDFEKLIMPGITHWQHPRFHAYFPAGNSFPSIIADMLSDAIGCVGFSWAACPAMTELELIMLDWFGKMIGLPAEFLPLTENGKGGGVIQSSASECNFVTLLAARFEVMKELRQRFPFVEEGLLLSKLIAYCSKEAHSSVEKACMIGMVKLRILETDSKFRLRGDTLRNAIQEDRNLGLIPFFVSTTLGTTSCCSFDVLSEIGPICKENELWLHVDAAYSGSAFICPEFRPLMNGIEYAMSFNTNPNKWLLINFDCSTMWVRDRFKLTQALVVDPLYLQHSWMDKSIDYRHWGIPLSRRFRSLKLWFVIRMYGIDGLQKYIREHVRLAKKMETLLRADAKFEIVNEVIMGLVCFRMKGDDELNQTLLTRLNASGRIHMVPASLGDRFVIRFCVCAENATDKDIEVAYEIIAQATQHVLHDSVKAVIAEEDEEAVALEEMVADLNITETPEKCLTRQNSANAAESGQKLERQLSKEEILAQKQHESLAKKRSFLVRMVSDPKCYNPKIVRHLNMANHRKMSQDLYRDRTLMQTISHSQRPNRLSQSPGSAGSAFFDDDDDRIVADVQTGLQTPI
Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter . Involved in the regulation of egg laying, which is inhibited by tyramine . Also involved in controlling locomotion and head movements . Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling .
Q95ZS2
O29322
TOP6A_ARCFU
Type II DNA topoisomerase VI subunit A
Archaeoglobus
MKEIERRCLRALIGIVQNIYDQMKAGQVPELHIATRTKYNIEFNEESEVWVYGDRKSVRSAKTVKGAYRILKMTYVIGFLKEQLNLNKSSTLRELYYISEGWGAAKFEEQPESDRLVEDLEILTNFQREHFHIRPEEDGATVIGPLRVREETRRGVREIHCQDDVGEGGYQIPVNVDKIEFVDHDAKFVIAIETGGMRDRLVENGFDEKYDAIIVHLKGQPARSTRRLLRRLNTELNLPVVVFTDGDPWSYRIFASVAYGSIKSAHLSEYLATPAAQFVGIRPTDIVKYDLPADKLTEEDIKALNAILTDPRFDSEFWKKEVNLQLEINKKSEQQALAKYGLDYVTDVYLPERLSELGVI
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
O29322
Q5X5C5
YBEY_LEGPA
Endoribonuclease YbeY
Legionella
MTYHIDIQNATGKLLPLSEDEITKLASLALRDHKQDAELTVRLVDVEEMTYLNHTYRKKNKPTNVLAFPCSLPANIELECPLLGDVVICPEVLLAESAQFNKSLHAHWSLILIHGVLHLLGYDHIKDEEASIMQMLEAKLLAELGYANPYEVEENELE
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q5X5C5
Q07H53
Y4812_RHOP5
Nucleoid-associated protein RPE_4812
Rhodopseudomonas
MADFLGMMKQAAQLQSKMKEMQSELDRIEVEGISGGGLVNVRMSAKMEVRAVKIDPSLLNPDEVGVLEDLLVSALADAHRKAEAAMQDKMKTLTGGLSLPPGLGL
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q07H53
B2T0I5
YQGF_PARPJ
Putative pre-16S rRNA nuclease
Paraburkholderia
MSLPAGREATLLAFDYGEKRIGVAVGNSLTRRARPLVIVQNRSREYRFEAVGKLIAEWKPDALVVGLPFHPDGAPHEMTQLAKRFGNQLNGRFNLPVTWVDERYSSVEAKAEIRAGNGRADMLDAEAASIILQQYLDGLSDDHEFH
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
B2T0I5
Q5HL88
XYLB_STAEQ
Xylulose kinase
Staphylococcus
MVKEVVLGIDLGTSAIKIIAVDQLGNVIESVSETLKLYQENPGYSEQDPNEWFEATKKGIKELIQSTEMSDKIVKGISFSGQMHGLVIVDDNGIPLRKAILWNDTRNSIQCRQIEDIYGERLNYNPILEGFTLPKMLWVQQHEPEIWNRVDVFMLPKDYLRYCLTQTIHMEYSDACSTLLFNPENYEWTRDVGDTFNIGDIYPPLVKSHSYVGNVTSSLAKELGLSSDVAVYAGGGDNACGAIGAGVIHDKSALCSIGTSGVVLNVEYQRVTSYDSNLHLFNHSVPDTYYAMGVTLAAGYSLNWLKQTFFENESFEEILNLAASSKMGANGLLFTPYLAGERTPHGDAQIRGSFIGISGQHTKADFARAVIEGITYSLYDSIKIMRRAGHEMNSITSIGGGAKSRFWLQLQADIFNVQIKRLKHEEGPSMGAAILAAYGLGWFKTIESCVEAFIKVDEVFEPNNENHDLYEQYYSVYEAIYKQTKQLTADLLTITN
Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.
Q5HL88
Q888A0
UPP_PSESM
UPRTase
Pseudomonas
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATADLTLESYDIQGWAGTVSVEKIAGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKEIRAMVLVAAPEGIAAVERAHPDVMIYTASIDERLNEHGYIIPGLGDAGDKIFGTKQKDA
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Q888A0
Q31C15
TAL_PROM9
Transaldolase
Prochlorococcus
MKSILEQLSSMTVVVADTGDLDSIKKFQPRDATTNPSLILAAAKNPDYVKLIDKAIESSENTLPNGFSEIELIKETVDQVSVFFGKEILKIISGRVSTEVDARLSFDTEATVKKARKLINLYKNFGIEKERILIKIAATWEGIKAAEILEKEGIKCNLTLLFNFCQAVTCANANITLISPFVGRILDWHKAKTGKTSFIGAEDPGVISVTQIYKYFKEKGFKTEVMGASFRNLDEIKELAGCDLLTIAPKFLEELKREKGVLIRKLDASTKINNSIDYKFEEKDFRLSMLEDQMASEKLSEGITGFSKAIEELEELLIERLSEMKNHKLISAN
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Q31C15
Q9SP55
VATG_CITLI
Vacuolar proton pump subunit G
Citrus
MTSNRGQGGIQQLLAAEQEAQHIVAAARNAKMARLKQAKEEAEREIAEYRAQVEREFQRKLAESVGDSGANVKRLEQETEVKIHHLKAGAEKIQYDVVQMFLKHVTTVKN
Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Q9SP55
Q8X884
TUSC_ECO57
tRNA 2-thiouridine synthesizing protein C
Escherichia
MKRIAFVFSTVPHGTAAGREGLDALLATSALTDELAVFFIADGVFQLLPGQKPDAVLARDYIATFKLLDLYDIEQCWVCAASLRERGLDPQTPFVVEATPLEADALRRELANYDVILRF
Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions.
Q8X884
Q82TN5
Y1849_NITEU
Nucleotide-binding protein NE1849
Nitrosomonas
MQVIIISGLSGSGKSIALKVLEDSGYYCVDNLPASLLVVLINHLQTQQHAYVAVAIDMRSGENITVLPWQLKMIDKSIQIKFIFLEARTETLMQRFSETRRRHPLSDKNITLEEAIRREREALATLTGLGHHIDTSSLRPNVLRAFIKDFIADSRSPSQLTLLFQSFGYKHGIPLDADLVFDIRCLPNPFYDPQLKELTGHDPEVIRFMESQPDASKMLRDISSFLGTWLPAYIRDNRAYLTVAIGCTGGQHRSVYFAEKLALHFHDSAHVLVRHRGLAEYKPHYARR
Displays ATPase and GTPase activities.
Q82TN5
O81123
ZIP1_ARATH
ZRT/IRT-like protein 1
Arabidopsis
MSECGCFSATTMLRICVVLIICLHMCCASSDCTSHDDPVSQDEAEKATKLKLGSIALLLVAGGVGVSLPLIGKRIPALQPENDIFFMVKAFAAGVILCTGFVHILPDAFERLSSPCLEDTTAGKFPFAGFVAMLSAMGTLMIDTFATGYYKRQHFSNNHGSKQVNVVVDEEEHAGHVHIHTHASHGHTHGSTELIRRRIVSQVLEIGIVVHSVIIGISLGASQSIDTIKPLMAALSFHQFFEGLGLGGCISLADMKSKSTVLMATFFSVTAPLGIGIGLGMSSGLGYRKESKEAIMVEGMLNAASAGILIYMSLVDLLATDFMNPRLQSNLWLHLAAYLSLVLGAGSMSLLAIWA
Mediates zinc uptake from the rhizosphere. May also transport copper and cadmium ions.
O81123
Q4UGL5
TCTP_THEAN
Translationally-controlled tumor protein homolog
Theileria
MKVYRDLYSNDEVCSDAYDHLDPFDNPDLSSVAFEVKTSKVAKGEEDYGIGYNDEEGGDQMNVDPNVEVVVDVVDKFALQSLPLTKKDYSSYIKKYIQRLVATLQEKNPERVEPFKTSVSEFVKHVLANFDDFEFYVGESLDYEAGLVYGYYKGEEVSPRLVFLKDGLVEERY
Involved in calcium binding and microtubule stabilization.
Q4UGL5
A6VW19
TIG_MARMS
PPIase
Marinomonas
MQVSVETTSPIERVLTISVPAARVDEKVNSEVAKTAKTIRIDGFRKGKVPVSVVKKRYGQGIRLDAVEQIMRDAYVEAIQKESIQPAGMPSIEPKNFAEGADLEFVVKIEVYPEVTLADNSAIKVDRVVSDVTEADVDTMLETLRKQNAEWSAVERESADGDQVTIDFVGYLGDEAFDGGAAEGHKLVLGSNTMIPGFESGILGAKAGEERTISVTFPEDYQAENLKGKEATFKITVSEVAEQILPELNDAFVEKFGLEEATVAALRAEVRKNMERELNQAIKSKLKNALFEGLSSINEVEVPSALVDQEVDALRKQAAQQFGGQGFDASQLPAELFQEEAKKRAKLGLLISEVIKKDDLKVDDDRVRAFLEDMAQAYQEPQQVIDFYLKNKEQLAQVQSAVLEEQVVDKLLESAQVTEVTLGYEDAIKPNAQAEEAGEEA
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
A6VW19
A6UC29
UREG_SINMW
Urease accessory protein UreG
Sinorhizobium
MPSKNGPLRVGIGGPVGSGKTALTEKLCKAMRERYSLAVVTNDIYTKEDAEALVRMQALPSERIVGVETGGCPHTAIREDASINLQAIADLNRRLPELDLVFIESGGDNLAATFSPDLADLTIYVISVCQGEEIPRKGGPGITKSDLLVINKKDLAPHVGADLEIMERDAARMRGEKPFVFSDMKRGDGVERIVDFLILHGGL
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
A6UC29
B2UX14
TIG_CLOBA
PPIase
Clostridium
MEAKVEKIETNVVKLEIKVEAEKFDAALTKAYNKNKGKYNVPGFRKGKVPMAILKKMYGIEIFYDDAVNIAIDESYNEALKAEDIRPVDYPKVDIVEIGEGKELVYTATVTTYPEVEIGEYKGLDIKKPSYEVSEEEVEKQVKEMQSKNARVETKEEGTIADGNIAIIDFKGFVDGEAFEGGEGTDYPLEIGSGTFIDNFEEQLVGLAIGDKKEVNVTFPENYGKEELNAKPAMFEVTVKGIKVKELPELDDEFAKEVSEFDTLAELKENVKKRLEESNNERAEREFEEAVITSIIETSKIDLPEVMLTKEIDSMMKDLESRLQYQGLSLDQYMEFTGNTIEKMREFMKENAERKVKADIILEAVAKAEEVKATDEQLNERALELGRMYGPKDPKKMANILLKAQKAMIEKDIIIENTLKLIKESCK
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
B2UX14
Q9V2C0
WTPC_PYRAB
Molybdate/tungstate import ATP-binding protein WtpC
Pyrococcus
MLRVESVSKDYKEFKLRDISFDVKKEEHFIILGPSGAGKTVLLEIIAGIIEPDEGRIILNGVDVTSYPPEKRNLAYIPQDYALFPHMTVYDNIAFGLKLRRISRQEIDRKVKEISKVLGIEHLLHRKPRTLSGGEKQRVAIARALVIEPELLLLDEPFANLDVQTKSRFMTEMKVWRKELGFTSLHVTHSFEEAISLGDRVGVMLRGRLVQVGDVKEVFSNPVDEGVARFLGFENIIEGVAKGNILEANGVKITLPISVEGKVRIGVRPEDIILSTEPVKTSARNEFRAEVIGIEELGPLVRVNLKIGGITLKAFITRSSLIELGISEGREVYVSFKTSAIKVF
Part of the ABC transporter complex WtpABC involved in molybdate/tungstate import. Responsible for energy coupling to the transport system.
Q9V2C0
P68423
TXH9_CYRSC
Huwentoxin-IX
Cyriopagopus
IICAPEGGPCVAGIGCCAGLRCSGAKLGLAGSCQ
Intracisternal injection paralyzes mice.
P68423
Q8SPP9
TSHR_PIG
Thyroid-stimulating hormone receptor
Sus
MSLTPLLQLALLLALPRSLRGKGCPSPPCECHQEDDFRVTCKDIHSIPPLPPNTQTLKFIETHLKTIPSRAFSNLPNISRIYLSIDATLQQLESQSFYNLSKMTHIEIRNTRSLTYINPGALKDLPLLKFLGIFNTGLRIFPDLTKVYSTDVFFILEITDNPYMTSIPANAFQGLCNETLTLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTVIDKDAFGGVFSGPTLLDVSYTSVTALPPKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRSLRQRKSVNAVNGPFYQEYEEDLGDSSVGNKENSKFQDTHSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGGSEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNVFVLVILLTSHYKLTVPRFLMCNLAFADFCMGMYLLLIASVDLYTQSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYAIMAGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIILVLLLNIVAFTIVCSCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGFCKRQAQAYRGQRVSPKNSTGIQVQKVTQNMRQSLPNMQDDYELLENSHLTHKKHDQISKEYKQPVL
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Q8SPP9
Q1WG82
ZGLP1_MOUSE
GATA-like protein 1
Mus
MEAAQAGDLTRRQELLAPPCLDTESLRKSRPPALEPGALRCLTPNIRSLWPTCQDSVSTALPFLQEKEKGLPGSPSPATQVLGSCWELMVIGMSDHLSMARNPRGTQCPNLEISSATSPASLQRRPRKQLNPRMGIEKVDPRFKGVTLEFQIQPDSSLQIVPTYSLPGRSCSQKLPASPSKALASPGSSEALGPRRCASCRTQRTPLWRDAEDGTPLCNACGIRYKKYGTRCSSCWLVPRKSIQPKRLCGRCGMSQDPHLSPTQEL
Transcriptional regulator that plays a key role in germ cell development . Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry . Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells . Regulates expression of STRA8, a central downstream effector for the meiotic program . Acts independently of retinoic acid (RA) . In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase .
Q1WG82
Q8CX20
TRUA_STRA5
tRNA-uridine isomerase I
Streptococcus
MTRYKAQISYDGSAFSGFQRQPNCRTVQEEIERTLKRLNSGNDVIIHGAGRTDVGVHAYGQVIHFDLPQARDVEKLRFGLDTQCPDDIDIVKVEQVSDDFHCRYDKHIKTYEFLVDIGRPKNPMMRNYATHYPYPVIIELMQEAIKDLVGTHDFTGFTASGTSVENKVRTIFDAKIQFEASKNLLIFTFTGNGFLYKQVRNMVGTLLKIGNGRMPISQIKTILQAKNRDLAGPTAAGNGLYLKEIIYEDEECFSNFRK
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Q8CX20
B6JFP6
TATA_AFIC5
Sec-independent protein translocase protein TatA
Afipia
MGLSFQHILILLVVVLLLFGRNKISDLMGDFAKGIKAFKKGMSDDEVETAKSDSIKTIDNTGKPTNVQANPQRQDSTV
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
B6JFP6
Q0SPB0
TPIS_BORAP
Triose-phosphate isomerase
Borreliella
MRKTFLAGNWKMHYTSAEASIVAKQIATEVKTLNDDFVIMITPPFTALSKVSECIKGSNILLGAQNMSYMESGARTSEISPSMLLEFGVEYVILGHSECRLYLAETDEIINKKIRAGLKHSFKYLILCVGETLDERDSGKTLDVVLSQVKKGLDCVSESDIKRIILAYEPVWAIGTGKTATKEEAEEVHKAIRLEIMKLYSKSASDNIIIQYGGSVNASNIKELMNEPNIDGALIGGASLKAESFLSIINNVR
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q0SPB0
Q9XFH9
TRXF2_ARATH
Thioredoxin F1
Arabidopsis
MPLSLRLAPSPTSFRYSPITSTGAGGFSPVKQHCRIPNSGVATKIGFCSGGGGVLDSGRRIGSCVVRCSLETVNVTVGQVTEVDKDTFWPIVKAAGDKIVVLDMYTQWCGPCKVIAPKYKELSEKYQDMVFLKLDCNQDNKPLAKELGIRVVPTFKILKDNKVVKEVTGAKYEDLLAAIEAARSG
Probable thiol-disulfide oxidoreductase involved in the redox regulation of enzymes of both reductive pentose phosphate pathway (Calvin-Benson cycle) and oxidative pentose phosphate pathway.
Q9XFH9
Q8FT12
TRPB2_COREF
Tryptophan synthase beta chain 2
Corynebacterium
MTTPATPTRQTLLDAYFGEYGGQFVPEVLLPALDELERAYVEALEDPTFQQELDDLYTNYLGRPTPITECANLPLEGQGRGTARIFLKREDLVHGGAHKGNQTIGQALLAKRLGKTRLIAETGAGQHGTATAMVAALFGMKCTVYMGAKDVARQQPNVYRMRLMGAEVVAVDEQSGNGLSSAIDVAINDWVNNLEDTHYLLGTAAGPHPFPTLVKKFHSVISRESREQMLERTGALPDAVVACVGGGSNAIGAFAQYLEDQPGNEKVRLIGVEPAGYGLDTDLNGAPIHEGRTMHLHGSNSYALLDEDGNLRNSHSVSAGLDYPGVGPEHAHLKDTGRAEYVGATDAEALQAFRMLSRYEGIIPALESSHALAHALKMAAEATEPINILVNLSGRGDKDVAYVRQLLGDHAALDPATDVLTEVDVLGVLEELTPQADTA
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Q8FT12
A6SZ08
UREE_JANMA
Urease accessory protein UreE
Janthinobacterium
MLTLNTKLEKADQIDGELILPYDQREKSRLRATMVSGEDVAVFTVRGTILRDGDILRGDDGRIVKITAAKEPTYRVEALSPHQLLRCAFHLGNRHTQAQIGNGFLRIRKDAVLKEMLEGLGAKVEEELAAFEPESGAYGGGHHHHGDDGHHPLAPIPLRQKIHRPSDKAE
Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.
A6SZ08
Q91242
THAB_PAROL
Nuclear receptor subfamily 1 group A member 1-B
Paralichthys
MAQWPEKEEEEQPMFGEEYTGYIPSYLEKDEPCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYDCCCIIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRRLIEENRERRKKEEIVKTLQNRPEPTGAEWELIRMVTEAHRHTNAQGAQWKQKRKFLPDKIGQSPVAPTSDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSEQLPCEDQIILLKGCCMEIMSLRAAMRYDPESETLTLSGEMAVKREQLKNGGLGVVSDAIFDLGKSLAQFNLDDTEVALLQAVLLMSSDRSGLTCMDKIEKCQETYLLAFEHYINYRKHNIPHFWPKLLMKVTDLRMIGACHASRFLHMKVECPNELFPPLFLEVFEDQEV
High affinity receptor for triiodothyronine.
Q91242
Q3K6Y9
UPP_PSEPF
UPRTase
Pseudomonas
MSIQEIRHPLIRHKLGLMRRADISTKNFRELAQEVGALLTYEATKDLPLETYDIEGWCGTVSVEKIAGKKITVVPILRAGIGMLEGVLSLIPGAKVSAVGVARNEETLQAHTYLEKLVPEIDERLAMIIDPMLATGSSMVATIDLLKKAGCKDIRAMVLVAAPEGIAAVEQAHPDVIIYTASIDQKLNEHGYIIPGLGDAGDKIFGTKQKDA
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Q3K6Y9
A5EJY3
UREG2_BRASB
Urease accessory protein UreG 2
unclassified Bradyrhizobium
MSRLALTRADEPMTAARVGIGGPVGSGKTALVERLIPALQTRGIDIAVITNDLVTAEDAERVRRSGLIDPERVSAVEAGACPHTVIREDPTLNIEAADELERRFPGVELILLESGGDNLASTFSRDLTDFWMFVIDVAGGDDIPRKRGPGVIRADLLVINKVDLAPHVGVDLGRMQREATEVRGGRPVLLTNCRRGEGIEAIVDLLEREVLFRK
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
A5EJY3
Q12GA4
UBIA_POLSJ
4-HB polyprenyltransferase
unclassified Polaromonas
MLRRKLGLYLALIRWNRPAGWLLLLWPTLSALWVASHGFPGWHLLTVFTLGTILMRSAGCCVNDVADRDFDRHVKRTAQRPVTSGQVSVREALVLGAVLALLAFGLVLTTNAATIAWSFAALAVTLAYPFAKRYVSMPQAVLGVAFSFGIPMAFAAVQSRVPLLAWVLLLGNLCWVIAYDTEYAMVDRDDDLKIGMKTSAITLGRFDVAGVMLSYLVYLSVWALALADIPQAAIYWMAIGLAGLQALWHGWLIRKRERDDCFKAFRLNHWLGFTVFAGIALSYLAA
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Q12GA4
Q49ZH2
TOP3_STAS1
DNA topoisomerase III
Staphylococcus
MKSLIIAEKPSVGRDIANTLNINEKRNGYFENNKYIVTWALGHLVTNATPEQYDASYKEWKLNDLPIIPNKMKTIVISKTRKQFSTVQSLINNNKVKDIIIATDAGREGELVARLILDKAHNKKPTKRLWISSVTNKAIKEGFNKLQDGRKFNNLYHAALARSEADWIVGINATRALTTKYDAQLSLGRVQTPTIQLVQMRQNEINHFKPQTYYTMKLNAAGLTFHCTKPQSHPDKTVLESIKKAIDGQSGHIASISKTHKKAYPQQLYNLTDLQQDAYKRFHLGPKETLNTLQTLYERHKLVTYPRTDSNYLTDDMVDTLKDRLKAIMATSLKDMAKAQMSQTFSSKQRFVNNNKVSDHHAIIPTEVRPDINQLSQRESKIYMMIAQRYLENLMPPHEYEAIAIELKVGQHTFTFKDKVTTKLGFKAIYENKESINTQIDQLQKGTKLNVTKILIEEHETTAPPYFNEGSLLKAMESPQKFFDLSDKKHDKTLKDTGGIGTVATRADIIEKLFNMNAIEARDGKIKVTSKGKQILELAPQKLTSPLLTAEWEEKLLLIEQGKYNASQFISEMKAFTNQVVNEIKESEQNYKHDNLTTTECPTCGKFMIKVKTKNGQMLVCQDPQCKTKKNVQRKTNARCPNCHKKMTLFGRGKDAVYRCVCGHTETQAQMDKRHKNKKSDKVNKKDLKKYMNNDEGIENNPFQDALKGLKF
Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.
Q49ZH2
Q5UL10
UFOG2_FRAAN
UDP-glucose flavonoid 3-O-glucosyltransferase 2
Fragaria
MAPVSNQAGGHVAVLAFPFSTHAAPLLNIVCRLAAAAPSTLFSFFNTKQSNSSILASDTSVLRYTNVCVCEVADGVPEGYVFVGKPQEDIELFMKAAPDNFRKCLEASVAESGREVSCLVTDAFFWFGAHMADDMGGVPWVPFWTAGPASLSAHVHTDLIRNTTSGDCHDEKETITVIAGMSKVRPQDLPEGIIFGNLESLFSRMLHQMGLMLPLATAVFINSFEELDPVITNDLKSKFKRFLNVGPLDLLEPTASAATTTPQTAEAVAGDGCLSWLDKQKAASVVYVSFGSVTRPSPEELMALAEALEASRVPFLWSLRDNLKNPQLDEFLSKGKLNGMVVPWAPQPQVLAHGSVGAFVTHCGWNSVLESVAGGVPLICRPFFGDQKLNARMVEDVWKIGLRLEGGVFTKNGMLKSLDMLLSQDKGTKMKNKIHTLKQLAQQAVEPKGSSTRNFESLLEMATTN
In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments . Anthocyanidins are the preferred substrates, while flavonols are only a minor substrate in vitro .
Q5UL10
Q9XWU8
VMP1_CAEEL
Ectopic P granules protein 3
Caenorhabditis
MAKKQKKSTEKSERTVEFKEPPKPANSEERLKPAGRGMKPSPSQNTLNRMERETIVFWRRPHIVIPYALMEIAHLAVELFFKILAHKTVLLLTAISIGLAVYGYHAPGAHQEHVQTIEKHILWWSWWVLLGVLSSIGLGSGLHTFLIYLGPHIAAVTMAAYECQSLDFPQPPYPESIQCPSTKSSIAVTFWQIVAKVRVESLLWGAGTALGELPPYFMARAARISGQEPDDEEYREFLELMNADKESDADQKLSIVERAKSWVEHNIHRLGFPGILLFASIPNPLFDLAGITCGHFLVPFWSFFGATLIGKALVKMHVQMGFVILAFSDHHAENFVKILEKIPAVGPYIRQPISDLLEKQRKALHKTPGEHSEQSTSYLAWGLSLMVTFMILFFFLSIVNSLAKDYHKRLWERKRRQNKDLIDEENQSFEEEEEEAVTPPSSCPLLLSDGFEGVVVKK
Involved in autophagy . Thought to act in autophagasome and omegasome formation .
Q9XWU8
B9E198
YQGF_CLOK1
Putative pre-16S rRNA nuclease
Clostridium
MRILGLDIGNKTIGVALSDPLGITAQGITTIKRKGEDRDIEELKAICDKYKVEVIVCGLPKNMNGTLGPQSEKVLKFCNIIEEVINLPIKMWDERLTTVAANKAMLEADLSRAKRKKIVDKMAATYILQGYLDRISK
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
B9E198
Q9R6P9
THIO_MYCGA
Thioredoxin
Mycoplasma
MKHITNKAELDQLLSTNKKVVVDFYANWCGPCKILGPIFEEVAQDKKDWTFVKVDVDQANEISSEYEIRSIPTVIFFQDGKMADKRIGFIPKNELKELLK
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.
Q9R6P9
Q5FA59
TRMD_NEIG1
tRNA [GM37] methyltransferase
Neisseria
MLIQAVTIFPEMFDSITRYGVTGRANRQGIWQFEAVNPRKFADNRLGYIDDRPFGGGPGMIMMAPPLHAAIEHAKAQSSQTAKVIYLSPQGKPLTHQKAAELAELTHLILLCGRYEGIDERLLQSSVDEEISIGDFVVSGGELPAMMLMDAVLRLVPGILGDIQSAEQDSFSSGILDCPHYTKPLEFQGMAVPEVLRSGNHGLIAEWRLEQSLRRTLERRPDLLEKRVLIPKESRLLNKILQEQREIQS
Specifically methylates guanosine-37 in various tRNAs.
Q5FA59
P75804
YLII_ECOLI
Soluble aldose sugar dehydrogenase YliI
Escherichia
MHRQSFFLVPLICLSSALWAAPATVNVEVLQDKLDHPWALAFLPDNHGMLITLRGGELRHWQAGKGLSAPLSGVPDVWAHGQGGLLDVVLAPDFAQSRRIWLSYSEVGDDGKAGTAVGYGRLSDDLSKVTDFRTVFRQMPKLSTGNHFGGRLVFDGKGYLFIALGENNQRPTAQDLDKLQGKLVRLTDQGEIPDDNPFIKESGARAEIWSYGIRNPQGMAMNPWSNALWLNEHGPRGGDEINIPQKGKNYGWPLATWGINYSGFKIPEAKGEIVAGTEQPVFYWKDSPAVSGMAFYNSDKFPQWQQKLFIGALKDKDVIVMSVNGDKVTEDGRILTDRGQRIRDVRTGPDGYLYVLTDESSGELLKVSPRN
Aldose sugar dehydrogenase with broad substrate specificity. The physiological substrate is unknown. Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L-arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network.
P75804
Q5WI27
XPT_ALKCK
Xanthine phosphoribosyltransferase
Alkalihalobacillus
MELLKEAIRKRGSVLSSGVLKVDQFLNHQVDTNLMSAIGEEFARLFADEHVTKVVTIESSGIAPSFMCAHSLQVPLIFARKKKSVTMDKENVYSSRVYSFTKKEYSEVTVSKDWLCPGDRVLIIDDFLANGQAATGLTQIVEEAGATVAGIGIVIEKSFQDGRALLEGKGYRIESLARISSLEGNKVQFVEESAHFAYNKS
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Q5WI27
Q9Y9H2
TRPB2_AERPE
Tryptophan synthase beta chain 2
Aeropyrum
MDLARYRFDLSIEEVPTSWYNILPDLPEEVPPPLNPKTGEPVDPSALAKLFPKALIEQEVSRERYIEIPGEVHEAYISFARRPTPLLRAVNLERALNTPAEIYYKYEGVTPTGSHKINTALAQAYYNKLEGVERLVTETGAGQWGSALSAAGAYFGVKVRVYMVRVSYLQKPYRRTLMELYGAEVYPSPSDKTEFGRKLLAENPNHPGSLGIAISEAIEDVINSGGNAKYSLGSVLNHVLLHQTVIGLEAEKQFREAGVYPDIMIGAVGGGSNFAGFTYPFIRHRLKGSSSTRFIAVEPKASPSMTRGVYTYDYGDTAGLTPLLKMHTLGHTYQVPPIHAGGLRYHGVAPTLSVLLKHGIVEARAYHQREVFRAAHMFAKAEGIVPAPESAHAVKAAIDEAIKARDEGRRVVIAFNLSGHGLLDLQGYREYLDGTLEDYEPEEIPASRR
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
Q9Y9H2
B8F6M2
YIDC_GLAP5
Membrane protein YidC
Glaesserella
MNSNRSLLIMGLLLVSFLIFTQWQQDYNPEIQAQKQAMAQAQTQQVANQSSDVPASSNAASINEQSTKGKTITIETDVLRLTVDTLGGDVVDSDLLKYNAELDSNTPFELLQDNGKVLYVAQSGLVGKNGIDTTAGRAQYQATAEKFALAEGQDEIALPLTFEKDGVVYTKTFTLKRGSYNVAVNYHIKNGTAETLEVQPYGQLKHTLVESTGNFAMPTYTGGAYSSSEVNYKKYSFDEMAKANLSVDTKAGWAAVLQHYFVSAWIPNQDAENNLYTRTGNGVGTIGYRGPVTQVAPNGEATITSHLWTGPKDQAAMAQVANNFDLTVDYGWAWFIAKPLFWLLTFIQSIVSNWGLAIIGVTIVVKTILYPLTKAQYTSMAKMRMLQPRIQEMRERFGDDRQRMSQEMMKLYKEEKVNPMGGCLPILLQMPIFIALYWTFMEAVELRHAPFFGWIQDLSAQDPYYIFPLLMGGSMYLLQKMSPTPIADPVQQKVMNFMPVMFTVFFLWFPSGLVLYWLTSNLITIAQQWLIYRNLEKKGLHTRVKK
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
B8F6M2
A3D7K4
TRUB_SHEB5
tRNA-uridine isomerase
Shewanella
MARRPKGRFIDGIVLLDKSTGMSSNFALQRVKRFFNANKAGHTGALDPLATGMLPVCLGEGTKFSQHLLDADKRYLVTAKLGERTDTSDSDGEVVQTRAIDFTEAQLLTALDFFRGETQQVPSMYSALKYQGQPLYKYAREGIEVPRESRPITVFELNFIGLEGDELTLDIHCSKGTYIRTIIDDLGEMLGCGAHVIMLRRTQVAQYPYARMVSLEQLEALVAQAHEQQIDPSILLDPLLLPMDTAVADFPEVNVPDAIAPYLMQGQAVRVPVNAGLKTDELVRITLGDIRRFVGIGTMNEDGLLAPKRLIVIHDEPAETD
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
A3D7K4
P28120
WNT52_EPTST
Protein Wnt-5(II)
Eptatretus
SGSCSLKTCWLQLAEFRKVGDHLKECYDGAVAMRLGRRRTLELRNSRLNPPSADDLVYLQTSPDYCTRNARTGSLGTVGRACNKTSAGMDGCELMCCGRGYDQFKATVVERCHCKF
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
P28120
Q28RL2
TPIS_JANSC
Triose-phosphate isomerase
unclassified Jannaschia
MARKLAAGNWKMNGVEADLAEVDALGEAVAAANCDVLLCPPATLIAPMAKRAGLMDLYVGGQTCHTAASGAHTGDVSAAMLADAGASHVILGHSERRADHGERSEDVAAQVTAAIDANLIAIICVGETEAERDANVTLNVVSSQLAGSIPTGATPAQIVVAYEPVWAIGTGRTPTLEQIAEVHDHIRSELAARRGSAANDIPLLYGGSVKPGNAAEIFAVSNVDGALVGGASLKASDFGGIIAALSAA
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q28RL2
P18735
ZG7_XENLA
Gastrula zinc finger protein XlCGF7.1
Xenopus
TREKPFTCTECGKGFSDKSNLRSHQRTHTREKPFTCTECGKSFSQKIGLHNHLKCHTGEKPFMCTECGKSFSNKSNLHTHRKIHTGERPYICTECGKTFPRKKNLQSHQTVHTQEKPFTCSECGKCFSQKKNLHTHQKIHTGEKPFKCNECGQAFLRKRNLLSHERIH
May be involved in transcriptional regulation.
P18735
Q9K9G6
THIX_HALH5
Formylaminopyrimidine transport permease protein ThiX
Halalkalibacterium (ex Joshi et al. 2022)
MKRSYQALEPTLFFLMLMVIWEISARMIGQPYLLPSPIQIVMRTIDLSESLFFTHLPATLAIISIGLALSIVLGILLSLLMFWNERVERAVYPLLVASQTIPVIALAPIFVLWFGYSIWSKVAVTVLLTFFPITVNTYDGLKSTNRQYEELFYTMGATKRQLFYRLFVPSTLPSFLTGLRIAVPLAVIGAAVGEWLGANEGLGYFSRRMMTQFDGPGVFAPIFILSLLGILGFAAIKKLENILLPWRKKQ
Participates in a thiamine pyrimidine salvage pathway as part of the ABC transporter complex ThiXYZ involved in the import of thiamine degradation products such as the formylaminopyrimidine N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP). Is probably responsible for the translocation of the substrate across the membrane.
Q9K9G6
Q9W552
VPS26_DROME
VPS26 protein homolog
Sophophora
MNFLGFGQSADIEIVFDGAEHKTAEVKGEDGKVEKMLLFYDGETVSGKVNVTLKKPGSKLEHQGIKIEFIGQIELYYDRGNHHEFKCLAKALARPGDLIQNNSYPFDFPKVEKQFEVYAGSNVRLRYFLRATIVRRISDITKEVDIAVHTLCSYPEMNNPIKMEVGIEDCLHIEFEYNKSKYHLRDTIIGKIYFLLVRIKIKHMEIAIIKKESTGTGPTMFNENETIAKYEIMDGAPVKGESIPIRVFLAGYNLTPTMRDINKKFSVKYFLNLVLMDTEDRRYFKQQEITLWRKADKPRYHGAQQHQQQQHQHVPLHAPPHLVSGPAAPTVAHSLISSSTDSGEVGGAPTAPGTAGSESKMGLFTRESPNQEFSQQQMDSPPLTPTPSTASVAVAVPTAASSVSEPAPERGIGDGAAAATTSASPVAMLSSSPPPLLPVSPLSRSETEASEQVQPEDEDLDAITPNTKKTGATPLATD
Component of the retromer complex which acts in conjunction with wingless (wg) and clathrin-mediated endocytosis to sustain a wntless (wls) traffic loop. This loop encompasses the Golgi, the cell surface, an endocytic compartment and a retrograde route leading back to the Golgi, thereby enabling wls to direct wg secretion. The hh and dpp signaling pathways do not require the retromer complex suggesting that it does not play a general role in exocytosis.
Q9W552
Q927P1
TRUA_LISIN
null
Listeria
MTRYKAIISYDGSGFFGYQVQPNTRTVQAEIEKALEKMHKGKSVRITASGRTDTGVHAKGQVIHFDSELDITAEKFQKALQVMTPFDISFLTVEEAPADFHARFGTVGKEYRYVIKRTKIFDPFSRNFALHYPYELDIAKMKQASERLIGEHDFTSFCSARTERDSKVRTLYSIDFYEEDAETLVIAFQGNGFLYNMVRILTGTLLDAGQGRISPDDITKALLAHDRQKLISKTAPPQGLYLWRVDYE
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
Q927P1
B4EPB7
TYPH_BURCJ
TdRPase
Burkholderia cepacia complex
MFLPQEFIRRKRDGQPLDRDGMAAFVRGVTDGSVTEGQVAAFAMAVYFNDLSTDERVALTLAQRDSGDVLDWRALDLDGPVIDKHSTGGVGDVVSLMLGPMVAACGGYVPMISGRGLGHTGGTLDKLSAIPGYDVMPATDAFRRTVREVGVAIIGQTARLAPADKRIYAIRDVTATVESVAMITASILSKKLAAGLDGLVMDVKVGSGAFMPTAEKSAELARSIVDVGNGAGMKTTAILTDMNQSLAPCAGNALEVACAIDYLTGKSRPARLHDVTMALSAELLVTGGLARDVGHAREKLQQALDSGAAAERFARMVVALGGPADLLDAPARHLARAVVIVPVPAPASGVVQRVDCRALGLAVVALGGGRTRAEDAIDVSVGLSALAEIGQRVEAGEPLGFVHARDEATAAHAADAIRRGYVLGDTGEAPPTLYQRVD
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
B4EPB7
Q89AN2
XGPT_BUCBP
Xanthine phosphoribosyltransferase
Buchnera
MSKKYIVTWDMLQIYARELAQKLLPVNQWKGIIAVSRGGLIPSALLARELNIRFVDTICVSSYDHNRLRDLKILKYAAGNSSQIIIVDDLVDTGGTGKIIRNLYPKAKFVTIFAKPMGKLLVDEYIIDIPQKVWIEQPWDMGVTYQSPLVRDL
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.
Q89AN2
A5WBX3
UVRC_PSYWF
Excinuclease ABC subunit C
Psychrobacter
MVTPSLTAQADDKQARLKHLIKRLPNLPGVYKMLGKNGDILYVGKAKSLKSRVNSYFAKTIDHPKTRALVSRIHDIETIITRSETEALLLEQNLIKEHRPPYNVLLRDDKSYLYVFISADQPYPRLAYGRGKAKHQKGKFFGPFPSAHAAKETLVLMQKMFQMRQCTNTFFRQRKRPCLEYQIKRCRAPCVGLVSAEEYAADVQNTIRFLKGDSSDIHTTLIEKMEHSAEALDFEKAAFYRDQLSMLREVQSRQAVYTVQGEADIISIASQAGMTCVNVLTVRGGRVLGGKNYFPDVDSNEPINDNLSAFITSFYFQVTDDLPAEIIISHELPDQMALQEALSTYFEAKTVIKTNVREHRAEWLDLAKLNAHNALKTKLGDYLELHARFAALKEVLEPVSQSSIDTIECFDISHTMGEATIASCVVFDQGGARKRDYRQYAIHGVQDGDDYAAMAQAITRRYKKHPLPDVLLIDGGKGQLSMAKNVLTELGLLNDTLLIGVAKGEGRKAGLEVLHFIEHEPLDLPMDSKALHLIMNIRDEAHRFAITAHRKKRDKRRSSSVLEAIPGLGEKRRRDLLNHFGGLQQLLGASQQELEGVNGIGKVMANTIYKVLHE
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A5WBX3
Q7VLH3
ZAPB_HAEDU
Cell division protein ZapB
Haemophilus
MSLSIIDQLEEKIKQAVETIQLLQLEVEELKEKNNNLTQERDGLRQEHEQLKVEQQNFQERLRSLLGQIDNV
Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
Q7VLH3
A8GIC1
TILS_SERP5
tRNA(Ile)-lysidine synthetase
Serratia
MNNNQLSAQLARQLGAHRHLLVAFSGGLDSSVLLHLLVGLRQQLPDLQLRAVHVHHGLSAFADQWVTHCRQQCVAWQLPLVVQHVQVDSQQGGIEAAARAARYSAFASTLAADETLLTAQHLDDQCETFLLALKRGSGPAGLSAMAAQTSLGNNHLLRPLLGHSRQQLEAYAQQHQLSWIEDDSNQDPRFDRNFLRLQVLPLLNQRWPHFAAATARSASLCAEQEQLLDELLAEQLHNLLDEDRALAIDGLLTCSAARRFALLRRWIALFGVTMPSREQLQRLWEEVALSREDAEPQLQLGQYQFRRFRRRLYLLPLMADLREISLSWSLDDSLMLPDGLGELVSGEGDICLRAPQSQQKVSIRFSAQGKHRILGRAHSRPIKKLWQELGIPPWQRERIPLIYYDDQLIAALGIFVSEAGQTPEGQQPWRLHWRKK
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
A8GIC1
B2RHI2
YIDD_PORG3
Putative membrane protein insertion efficiency factor
Porphyromonas
MRLIKAFLVQLLLLPIFFYKRFISPLTPPSCRFTPSCSSYAIEALRKYGPGKGLLLSIKRILRCHPWGGSGYDPVP
Could be involved in insertion of integral membrane proteins into the membrane.
B2RHI2
A3N0N5
YACG_ACTP2
DNA gyrase inhibitor YacG
Actinobacillus
MSETIVNCPTCNQDVIWKPESKYRPFCSERCQLIDLGEWANEEKRIAAVENDVMTSDLEGHY
Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.
A3N0N5
Q8NIH3
TRI5_FUSBO
Sesquiterpene cyclase
Fusarium
MENFPTEYFLNTSVRLLEYIRYRDSNYTREERIENLHYAYNKAAHHFAQPRQQQMLKVDPKRLQASLQTIVGMVVYSWAKVSKECMADLSIHYTYTLVLDDSSDDPHPAMLNYFDDLQAGREQAHPWWALVNEHFPNVLRHFGPFCSLNLIRSTMDFFEGCWIEQYNFGGFPGSDDYPQFLRRMNGLGHCVGASLWPKELFDERKNFLEITTAVAQMENWMVWVNDLMSFYKEFDDERDQISLVKNFVTCHEITLDEALEKLTQETLHSSKQMVAVFADKDPQVMDTIECFMHGYVTWHLCDARYRLHEIYKKVKDQDTEDAKKFCKFFEQAANVGAVAPSEWAYPQVAQLANVRAKGDVKEAQKPILSSIELVE
TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.
Q8NIH3
Q0TQZ9
XPT2_CLOP1
Xanthine phosphoribosyltransferase 2
Clostridium
MELLKDKIKKEGRVTEDNILMVDSFLNHQMDVEFFNEVGKEFKDRFKNDQIDKILTIESTGIGLGIITAQYFDNVPVVFGKKIERLPRNKREEVFNSEVYSFTKKTIYNVVVDKKFIKPGEKILIVDDFLANACAVFGLIDVVKQAGAEVVGVGIVIEKGFQSGRAHLEDKGIRVESLVTIDKIEDGEVYFK
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Q0TQZ9
Q56254
TFS_THECE
Transcription elongation factor IIS/RNA polymerase subunit homolog
Thermococcus
MKFCPKCGNLMLPDRKRKVWVCRSCGYEEPFDEEKDREKTVIKQEVKHKPDEGIVVIEQDLKTLPTTKITCPKCGNDTAYWWEMQTRAGDEPSTIFYKCTKCGHTWRSYE
Induces RNA cleavage activity in the RNA polymerase. In its presence, the cleavage activity of the RNA polymerase truncates the RNA back to position +15 in a stepwise manner by releasing mainly dinucleotides from the 3'-end of the nascent RNA. The truncated RNAs are able to continue elongation. Involved in transcriptional proofreading and fidelity. Misincorporation of nucleotides during elongation of transcription leads to arrested elongation complexes which are rescued by TFS-promoted removal of a dinucleotide from the 3'-end. TFS is able to induce a cleavage resynthesis cycle in stalled elongation complexes (resulting from the next missing nucleotide or a reduced incorporation rate of a wrong nucleotide) preventing misincorporation and enabling proofreading in a post-incorporation manner. Pausing of elongation complexes is the main determinant of TFS-induced RNA cleavage.
Q56254
Q96ME7
ZN512_HUMAN
Zinc finger protein 512
Homo
MSSRLGAVPATSGPTTFKQQRSTRIVGAKNSRTQCSIKDNSFQYTIPHDDSLSGSSSASSCEPVSDFPASFRKSTYWMKMRRIKPAATSHVEGSGGVSAKGKRKPRQEEDEDYREFPQKKHKLYGRKQRPKTQPNPKSQARRIRKEPPVYAAGSLEEQWYLEIVDKGSVSCPTCQAVGRKTIEGLKKHMENCKQEMFTCHHCGKQLRSLAGMKYHVMANHNSLPILKAGDEIDEPSERERLRTVLKRLGKLRCMRESCSSSFTSIMGYLYHVRKCGKGAAELEKMTLKCHHCGKPYRSKAGLAYHLRSEHGPISFFPESGQPECLKEMNLESKSGGRVQRRSAKIAVYHLQELASAELAKEWPKRKVLQDLVPDDRKLKYTRPGLPTFSQEVLHKWKTDIKKYHRIQCPNQGCEAVYSSVSGLKAHLGSCTLGNFVAGKYKCLLCQKEFVSESGVKYHINSVHAEDWFVVNPTTTKSFEKLMKIKQRQQEEEKRRQQHRSRRSLRRRQQPGIELPETELSLRVGKDQRRNNEELVVSASCKEPEQEPVPAQFQKVKPPKTNHKRGRK
May be involved in transcriptional regulation.
Q96ME7
A6VMV1
Y930_ACTSZ
Nucleotide-binding protein Asuc_0930
Actinobacillus
MELIIISGRSGAGKSVALRALEDIGYYCVDNLPIDLLPQLADILSQSQASAAISLDIRNLPNSSQHLDEILTELENKHQIKIIFLDADRSTLIRRYSDSRRLHPLSVQNQDLSLEAAIDAEQIQLDPLIQHANLIIDTAVLSTHELAERLREFLRGNSDKELKIVVESFGFKYGLPLDADYVFDVRFLPNPHWNPSLRPMTGLEQPVIDFLSKYEDVANFIYTTRNYIETWLPMLERNNRSYLTIAIGCTGGKHRSVYIAQQLGEYFQDKGKHVKIQHKSLEKHKNR
Displays ATPase and GTPase activities.
A6VMV1
P01224
TSHB_PIG
Thyrotropin beta chain
Sus
MTAIFLMSMLFGLACGQAMSFCIPTEYMMHVERKECAYCLTINTTICAGYCMTRDFNGKLFLPKYALSQDVCTYRDFMYKTVEIPGCPHHVTPYFSYPVAISCKCGKCNTDYSDCIHEAIKTNYCTKPQKSYVLEFSI
Indispensable for the control of thyroid structure and metabolism.
P01224