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taxon
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sequence
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2.75k
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5.51k
AlphaFoldDB
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Q9HEZ1
XYNA_PHACH
1,4-beta-D-xylan xylanohydrolase A
Phanerodontia
MKLSASFAALALLLPFVQAQSPVWGQCGGIGWTGPTTCTAGNVCQEYSAYYSQCIPASQATSVTSVSTAPNPPPTSHTSTSSAPSGASTSTAKLNTLAKAKGKLYFGTATDNGELSDTAYTAILDDNTMFGQITPANSMKWDATEPQQGQFTFSGGDQIANLAKSNGMLLRGHNCVWYNQLPSWVSNGKFTAAQLTSIIQNHCSTLVTHYKGQVYAWDVVNEPFNDDGSWRTDVFYNTLGTSYVQIALEAARAADPDAKLYINEYNIEYAGAKATSLLNLVKTLKAASVPLDGIGFQSHFIVGQVPTGLQSQLTTFAAQGVEVAITELDIRMTLPSTPALLAQQKTDYSNVIKACASVEACVGVTVWDWTDKYSWVPNTFSGQGAACPWDQNFVRKPAYDGIAIGFGN
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Q9HEZ1
P18026
TBB2_MAIZE
Beta-2-tubulin
Zea
MREILHIQGGQCGNQIGSKFWEVVCDEHGIDPTGRYMGTSDVQLERVNVYYNEASCGRFVPRAVLMDLEPGTMDAVRTGPYGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRMMMTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLIPFPRLHFFMVGFAPLTSRGSQQYRSLTVPELTQQMWDSKNMMCAADPRHGRYLTASAMFRGKMSTKEVDEQMINVQNKNSSYFVEWIPNNVKSSVCDIPPRGLSMSSTFVGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEEADYEEEEAAAE
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P18026
A3MZ07
UBIG_ACTP2
3-demethylubiquinone 3-O-methyltransferase
Actinobacillus
MNNIDQTELDKFEKMAATWWDPNGSFKPIHLLNPLRLDYIQQKANGLFGKKVLDVGCGGGILSEAMARAGATVTGIDMTTEPLEVARKHAEENGLSIDYRQTTIEDFVQNQTACHAEKFDVITCMEMLEHVPDPLSIIQSCKALLKPDGVLFFSTINRTLKAYMLVIIGAEYVLKMLPKGTHEFEKFIKPAELLNWCDMADLRCQEMKGYHFNPVTEKFWLNNDVSCNYIAMLK
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
A3MZ07
D5AKX9
TAUR_RHOCB
HTH-type transcriptional regulator TauR
Rhodobacter
MAIPVESFFLAPGGQGSLQHRLRQMVTEGILSGRFRPGDRMPSTRALAAHLGVARITVTLAYADLVASDYLLARGRSGTFVSAAAPDARKARPLPRDGARTDWARLLHPRAQGLPRPDRPRDWSLYRYPFIYGQADPELFDHQNWRACALQALGRREFHRLSADCYDEDDPLLVEYILRHILPRRGIAAVPSEVLITMGAQNGLWLAAQVLLGPGERAAMENPGYPGTRAVLGTTGAEVLSVDVDDRGLVPAQLPARLKLVVTTASHHCPTNATLPVERRLALLAAAEAGDFLILEDDYEFEMSFLQSAAPSLKSLDAGGRVVHVGSFSKSLFPGLRLGYLVAPAPFVAAVRALRATVLRHPPGQLQRTLALFLSLGHYDALVARMKAAYRLRREVMTKAIEDNGLQIAGQGGFGGSSFWMQAPGAVDTEDLALRLRAEGVLIEPGRVFFDPARERRNFYRLAYSSIGPAAIPEGIARIARALR
Transcriptional activator, which is essential for taurine-dependent expression of the tpa-tauR-xsc operon. Acts by binding to direct repeats in the promoter region.
D5AKX9
Q8EHI9
TORA_SHEON
Trimethylamine-N-oxide reductase
Shewanella
MNRRDFLKGLASTSFVALGGSSVLAPLNALANTGLNENEWLTTGSHFGAFKIKRKNGMIAEVKAFDLDKYPTDMINGIRGMVYNPSRVRYPMVRLDFLLKGHKSNTQQRGDFRFVRVTWDKALKLFKHSLDEVQTKYGPSGLHAGQTGWRATGQLHSSTSHMQRAVGMHGNFVKKIGDYSTGAGQTILPYVLGSTEVYAQGTSWPLILENSNTIVLWSNDPYKNLQVGWNAETHEAFAYLAQLKEKVKQGKIRVISIDPVVTKTQAYLGCEQLYVNPQTDVTLMLAIAHEMITQKLHDEKFIQGYSLGFEEFVPYVMGTKDGIAKTPEWAAPICGVEPHIIRDLAKTLVKGRTQIMMGWCIQRQQHGEQPYWMAAVLATMIGQIGLPGGGISYGHHYSSIGVPATTAAAPGAFPRNLDENQKPLFDSTDFKGASSTIPVARWIDAILEPGKTIDANGSKVVYPDIKMMIFSGNNPWNHHQDRNRMKQAFQKLECVVSIDVNWTATCRFSDIVLPACTTYERNDIDVYGAYANRGILAMQKMVEPLFESLSDFEIFTRFAALLGKEKEYTRNMSEMEWIETLYNECKAANAGKYEMPDFATFWKQGYVHFGEGELWTRHADFRNDPEINPLGTPSGLIEIFSRKIEQFGYDDCQGHPMWMEKAERSHGGPGSNKYPMWLQSCHPDHRLHSQMCESKEYRETYTVNGREPVYISPEDAKTRGIKDGDIVRVFNDRGQLLAGAVVSDRFPKGVVRIHEGAWYGPVGKDGSVEGGAEIGALCSYGDPNTLTLDIGTSKLAQACSAYTCLVEFEKYQGKAPKVSSFDGPIEVEI
Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.
Q8EHI9
Q82ZW3
THII_ENTFA
tRNA 4-thiouridine synthase
Enterococcus
MKYTEIMVRYGELSTKGKNRKTFIMQLAQNVKRALADFPALKIHADRDRMHILLNGEDSEEVIPKLSKVFGIQNFSPSIRIEKEMPAIRAMVQEVVREVYTPGKTFKITAKRSDHSFELDSNGLNQELGGAVIEAIPEIQVQMKKPDINLRIEIRKDAAYLSYETIRGAGGLPVGTSGRGMLMLSGGIDSPVAGYLAMKRGVEVEAVHFASPPYTSEQALQKAKDLAEKLVPYVGTIQFIEVPFTEIQEEIKRVVPQGYLMTITRRLMLRLTDAIREMRKGLVIINGESLAQVASQTLQSMVAINEVTSTPIIRPVVSMDKTEIIEIAEKIDTFELAIQPFEDCCTIFAPPQPKTRPRLDKAQEYEARLDLEGLMARALEGLKITEISAETAKDKQEDEFADFL
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Q82ZW3
Q6R3L0
YSL1_ARATH
Protein YELLOW STRIPE LIKE 1
Arabidopsis
MEIEQRRIMKREGEEEEDNNQLSLQEEEPDTEEEMSGRTIEPWTKQITVRGVFVSIVIGVVFSVIAQKLNLTTGIVPNLNSSAALLAFVFVQTWTKILKKSGFVAKPFTRQENTMIQTSAVACYGIAVGGGFASYLLGLNHKTYVLSGVNLEGNSPKSVKEPGLGWMTAYLFVVCFIGLFVLIPLRKVMIVDLKLTYPSGLATAVLINGFHTQGDAQAKKQVRGFMKYFSFSFLWGFFQWFFSGIEDCGFAQFPTFGLKAWKQTFFFDFSMTFVGAGMICSHLVNLSLLLGAILSYGLMWPLLDKLKGSWFPDNLDEHNMKSIYGYKVFLSVALILGDGLYTFVKILFVTIANVNARLKNKPNDLDDVGHKKQRKDLKEDENFLRDKIPMWFAVSGYLTFAAVSTVVVPLIFPQLKWYYVIVAYIFAPSLAFCNAYGAGLTDINMAYNYGKIGLFVIAAVTGRENGVVAGLAGCGLIKSVVSVSCILMQDFKTAHYTMTSPKAMFASQMIGTVVGCIVTPLSFFLFYKAFDIGNPNGEFKAPYALIYRNMAILGVQGFSALPLHCLQMCYGFFGFAVLVNVVRDLTPAKIGRFMPLPTAMAVPFLVGAYFAIDMCVGTLIVFVWEKMNRKKAEFMVPAVASGLICGEGLWTLPAAVLALAGVKPPICMKFLAS
Involved in iron loading of the seeds. Acts probably as a transporter of iron- and metal-nicotianamine chelates.
Q6R3L0
Q53M52
TBA2_ORYSJ
Tubulin alpha-2 chain
Oryza sativa
MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPGDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGDYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVNEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPSVVPGGDLAKVQRAVCMISNSTSVVEVFSRIDIKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGSEFDDGDEGDEGDEY
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q53M52
E5KCJ8
Y3IP1_TOBAC
Ycf3-interacting protein 1, chloroplastic
Nicotiana
MASNMLQLSLPPLSSSSSSLPFLSSSVYVLPFTHQRRHFSFFNVQNYRFRLSRSTSLGPLFVNKEEDSATYAVTEEEEDNDDDDPDPQSLEYVSQIKRVLELLKRNRDMLFGEVKLTIMIEDPRDVERRRLLGIDDENAPTRDDLAAALEEINEGKVPKDFAALQMLAEEMNSWPNLEVEATKQNKPGRSLYAKATDTGIDPKEAAKRLKIDWDSAAEIDESAESDEPDVPPALGYGALYLVSAFPIIIGISVVLILFYNSLQ
Nuclear genome-encoded factor that participates in photosystem I (PSI) biogenesis. Cooperates with the plastid genome-encoded protein PSI assembly Ycf3 in the assembly of stable PSI units in the thylakoid membrane.
E5KCJ8
Q9LSZ3
VUP1_ARATH
Vascular-related unknown protein 1
Arabidopsis
MMDTFSCNSYEQNHPHDDDIDIDAHDHDSHGGDHQEESGWTTYLDDFSNQYRTTHHEENDHQDKSSYSLLATSTSLVSDAATHAFSGKSFPVNFPAKLKFGRGRTKKICEDDSLEDTASSPVNSPKVSHFEHIQTPPRKIEDYVSSSFVMGNIRGMGDHQIQIQEGGEQKVTLMRNLIDGNNNNNNNNMDLRSRGLCVVPISMLANFNGRC
Involved in the regulation of xylem development and growth. May regulate secondary wall formation during vascular development by modulation of brassinosteroid, gibberellin and auxin hormone signaling pathways.
Q9LSZ3
Q2KA54
UVRC_RHIEC
Excinuclease ABC subunit C
Rhizobium
MNGRKLPDGGVLYDDTDESEDEIEVEGDVSAAPLAVAVDWNAGSLNETGLVGAELIGEFVKRLPNSPGVYRMLNAEGDVLYVGKARSLKKRVGNYAVGRVHSNRIAQMVRQTANMEFVTTRTETEALLLEANLIKRLRPRFNVLLRDDKSFPYILITGDHRAPAIFKHRGARARKGDYFGPFASAGAVGRTINSLQRAFLIRTCTDSVFETRTRPCLLYQIKRCSGPCTHEVSDEGYAELVQEAKDFLSGKSQKVKSHMAEAMNQAAEDLDFERAAIYRDRLAALSHVQSHQGINPAGVDEADVFAIHHEGGVSCIQVFFFRTGQNWGNRAYFPKADPQLSSAEVLNAFLAQFYDDKPVPKQIMLSETAEELELLAAALSEKAGHKVSILVPRRGEKRDLVDHVVGNAREAHGRKLAETASQSRLLEGFKETFGLAYAPQRIEIYDNSHIMGTNAVGGMVVAGPEGFVKNQYRKFNIKSTDITPGDDFGMMKEVMTRRFSRLIKEEGIPDRTAQAAAADAADMPFPAWPDVILIDGGQGQMTAVRAILAELGITDSVTAIGIAKGVDRDAGRERFFAPGRESFTLPPRDPVLYFIQRMRDEAHRFAIGSHRVRRKKEMVKNPLDEIGGIGPSRKRALLQHFGTAKAVSRAALSDLMAVEGISEAVAKQVYNHFHEDAAK
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q2KA54
B2SDJ2
TDH_FRATM
L-threonine 3-dehydrogenase
Francisella
MKALAKLKKQPGIWIINDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPMITGHEFAGEVVAKGDGVTSVDIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQGAFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALSFNLTGEDVLITGAGPIGLMVVKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTEGFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREMFETWYLMTSMLQAGMDMNPIITHRLHIDEFQKGFEIMKSGQCGKVILDWSS
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
B2SDJ2
A9CES6
TAGPE_AGRFC
D-tagatose 6-phosphate 4-epimerase
Agrobacterium tumefaciens complex
MTAILENLAAARRAGKPAGITSVCSAHPVVLRAAIRRAAASQTAVLIEATCNQVNHLGGYTGMTPRDFVAFVNSIAAEEGLPAELLIFGGDHLGPNPWRREKAEDALTKAAAMVDAYVTAGFRKIHLDASMGCAGEPAALDDVTIAHRAAKLTAVAEKAATEAGLPKPLYILGTEVPVPGGADHVLETVAPTEPQAARNTIDLHREIFAQHGLSDAFERVIAFVVQPGVEFGSDNVVAYDPQAAQSLSAVLDGEPRLVFEAHSTDYQTEPALAALVRDGYPILKVGPGLTFAYREALYALDMIASEMVGTYGDRPLARTMEKLMLSAPGDWQGHYHGDDITLRLQRHYSYSDRIRYYWTRPEALAAVSTLHKALDGKTIPETLLRQYLGELPLAAVAGKEPEEVLVAAVDQVLATYHAATGEGRH
Involved in galactitol and D-altritol catabolism. Catalyzes the epimerization of D-tagatose 6-phosphate to D-fructose 6-phosphate.
A9CES6
P55916
UCP3_HUMAN
Solute carrier family 25 member 9
Homo
MVGLKPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKVQMLRESPF
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
P55916
B5Z672
UREE_HELPG
Urease accessory protein UreE
Helicobacter
MIIERLVGNLRDLNPLDFSVDYVDLEWFETRKKIARFKTRQGKDIAIRLKDAPKLGLSQGDILFKEEKEIIAVNILDSEVIHIQAKSVAEVAKICYEIGNRHAALYYGESQFEFKTPFEKPTLALLEKLGVQNRVLSSKLDSKERLTVSMPHSEPNFKVSLASDFKVVMK
Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.
B5Z672
Q9V074
TYW31_PYRAB
tRNA wyosine derivatives biosynthesis protein Taw3 1
Pyrococcus
MRFTENFERAKKEALISLEIALRRGEVDEDIIPLLKKINEKPNYFTTSSCSGRISIMEMPDFGDKVNAKWLGKWHREVSLDEVLEAIRKHREGQLWLLVRSPILHVGARTLEDGIKLLNLGVSCGFKYSNIKSISDRKLIVEIRSTERLDALLGENGEILVSDDYMRKLVEIANAQVRRFKRKLKRFEERIEEL
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
Q9V074
A3QGU3
TRUB_SHELP
tRNA-uridine isomerase
Shewanella
MARKPRGRLVDGIVLLDKDTGMSSNFALQRVKRIYNAAKAGHTGALDPLATGMLPICLGEATKFSQHLLDADKRYLVTAKLGVRTDTSDSDGEVVQTRPINFTEQQLEEALEHFRGETMQVPSMYSALKYQGQPLYKYAREGKEVPREARPIKVFELNFIKLEGDELTLDIHCSKGTYIRTITDDLGEMLGCGAHVIMLRRTGVAGYPYDKMVTLEQLEALLAKAQEEERPPKELLDPLLLPMDTAVSGLKEINVSDELAHYLMNGNPVQVANLPIDELVRITLGEAKQFVGIGQMNDDGLLAPKRLVVLHDEQA
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
A3QGU3
Q940K0
UNI_ARATH
Protein UNI
Arabidopsis
MGSCFSLQVSDQTLNRIFNCLIGKSYIRTLEKNLRALQREMEDLRAIQHEVQNKVARDEARHQRRLEAVQVWLDRVNSVDIECKDLLSVTPVELQKLCLCGLCSKYVCSSYKYGKKVFLLLEEVKKLNSEGNFDEVSQPPPRSEVEERPTQPTIGQEDMLEKAWNRLMEDGVGIMGLHGMGGVGKTTLFKKIHNKFAEIGGTFDIVIWIVVSKGVMISKLQEDIAEKLHLCDDLWKNKNESDKATDIHRVLKGKRFVLMLDDIWEKVDLEAIGIPYPSEVNKCKVAFTTRSREVCGEMGDHKPMQVNCLEPEDAWELFKNKVGDNTLSSDPVIVELAREVAQKCRGLPLALNVIGETMSSKTMVQEWEHAIHVFNTSAAEFSDMQNKILPILKYSYDSLGDEHIKSCFLYCALFPEDGEIYNEKLIDYWICEGFIGEDQVIKRARNKGYAMLGTLTRANLLTKVGTYYCVMHDVVREMALWIASDFGKQKENFVVQAGVGLHEIPKVKDWGAVRKMSLMDNDIEEITCESKCSELTTLFLQSNKLKNLPGAFIRYMQKLVVLDLSYNRDFNKLPEQISGLVSLQFLDLSNTSIEHMPIGLKELKKLTFLDLTYTDRLCSISGISRLLSLRLLRLLGSKVHGDASVLKELQQLQNLQELAITVSAELISLDQRLAKLISNLCIEGFLQKPFDLSFLASMENLSSLRVENSYFSEIKCRESETESSYLRINPKIPCFTNLSRLEIMKCHSMKDLTWILFAPNLVVLLIEDSREVGEIINKEKATNLTSITPFLKLEWLILYNLPKLESIYWSPLPFPVLLTMDVSNCPKLRKLPLNATSVSKVEEFEIHMYPPPEQENELEWEDDDTKNRFLPSIKPYKYFVYPGMSFLTV
Involved in disease resistance via the salicylic acid (SA) signaling pathway . Involved in shoot architecture development via the cytokinin signaling pathway .
Q940K0
A7MLI3
ZNTB_CROS8
Zinc transport protein ZntB
Cronobacter
MEAIKGSEVNVPDAVIAWLLDGHGGVKPLQDDAVIDKDHPCWLHLNYANPESAQWLTETPLLPNLVRDALAGESLRPRVTRMGDGTLITLRCINGSTDERPDQLVAMRLYIDERLIVSTRQRKVLALDDIIHDLNEGSGPADVGGWLVDACDALTDHASEFIEELHDKIIDLEDNLLEEIVPPRGVLALLRKQLIVMRRYMSPQRDVFSRLASERFSWMTDDHRRRMQDIADRLGRGLDEIDACIARTAVMADEISQTMQESLSRRSYTMSLMAMVFLPSTFLTGLFGVNLGGIPGGGWHLGFSVFCVALVLLIGGVTWWLHRSKWL
Zinc transporter. Acts as a Zn(2+):proton symporter, which likely mediates zinc ion uptake.
A7MLI3
Q8UEP9
TATA_AGRFC
Sec-independent protein translocase protein TatA
Agrobacterium tumefaciens complex
MGSFSVWHWLIVLVIVLVLFGRGKIPELMGDVAKGIKSFKKGMADEDQTPPPADANANAKTVDHKADEIK
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q8UEP9
Q8WZE0
TBB_USTVI
Beta-tubulin
Microbotryum
MREIVSLQAGQCGNQIGTKFWEVVSEEHGIDGTGQYTGTSDLQLERINVYYNETGTGKYVPRAVLVDLKPGTMDVIQGGPLGGLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDQVLDVVRKEAEGTDCLQGFQLTHSLGGGTGSGMGTLLVSKIREEFPDRMMATFSVVPSPKVSDTVVEPYNAVLSVHQLVENSDETFCIDNEALYDICFRTLKLSAPTHGDLNGLVSIVMSGITTCLRFPGQLNSDLRKLAVNMVPFPRLHFFTVGFAPLTARGSSQYRAVTVAELTAQMFDAKNMMAASDPRHGRYLTVAAYFRGKVSMKEVEDQMVSIQQKNSQYFVEWIPNNVQSAHCEVAPRGLKMSVTFIGNNTSIQELFKRVGDHFDVMFRRRAFLHWYTGEGMDEMEFSEASANMHDLIAEYTQYQEAGVDDEEEVAYEEEPQE
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q8WZE0
A0KEH3
UBID_AERHH
Polyprenyl p-hydroxybenzoate decarboxylase
Aeromonas
MKYKDLRDFIAQLEQSGQLKRISREIDPYLEMTEISDRTLRAGGPALLFENPKGYTMPVLTNLFGTPDRVAMGMGQPNVAALRQVGIWLSYLKEPEPPRGFKELMEKLPIFKQVLNMPTKRLSSAPCQQRVLEGEAVDLDQIPIQHCWPGDVAPLVTWGLTITRGPYKKRQNLGIYRQQKIGKNKLIMRWLDHRGGAIDFREWQEAHPGERFPVVVALGADPATILGAVTPVPDTLSEYAFAGLLRGSRTEVVKAVSCDLEVPASAEIVLEGYLEPGEMAPEGPYGDHTGYYNEVDEFPVFTITHMTMRKDAIYHSTYTGRPPDEPAVLGVALNEVFVPLLQKQFPEIVDFYLPPEGCSYRMAVVTIKKRYPGHAKRVMLGVWSFLRQFMYTKFVIVCDDDINARDWKDVIWAITTRMDPARDTTLIEHTPIDYLDFASPVSGLGSKMGLDATNKWPGETNREWGQPIVQDEAVKQKIDALWDELNILG
Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.
A0KEH3
A1YG60
ZKSC8_PANPA
Zinc finger protein 192
Pan
MAEESRKPSAPSPPDQTPEEDLVIVKVEEDHGWDQESSLHENNPLGQEVFRLRFRQLCYQETLGPREALIQLRALCHQWLRPDLNTKEQILELLVLEQFLTILPEELQTLVKEHQLENGEEVVTLLEDLERQIDILGRPVSARVHGHRVLWEEVVHSASAPEPPNTQLQSEATQHKSPVPQESQERSMSTSQSPTRSQKGSSGDQEMTATLLTAGFQTLEKIEDMAVSLIREEWLLDPSQKDLSRDNRPEDFRNVFSLGGETRSENRELASKQVISTGIHPHGETAAKCNGDVIRGLEHEEARDLLGRLERQRGNPTQERRHKCDECGKSFAQSSGLVRHWRIHTGEKPYQCNVCGKAFSYRSALLSHQDIHNKVKRYHCKECGKAFSQNTGLILHQRIHTGEKPYQCNQCGKAFSQSAGLILHQRIHSGERPYECNECGKAFSHSSHLIGHQRIHTGEKPYECDECGKTFRRSSHLIGHQRSHTGEKPYKCNECGRAFSQKSGLIEHQRIHTGERPYKCKECGKAFNGNTGLIQHLRIHTGEKPYQCNECGKAFIQRSSLIRHQRIHSGEKSESISV
May be involved in transcriptional regulation.
A1YG60
B2HLS6
Y358_MYCMM
Putative S-adenosyl-L-methionine-dependent methyltransferase MMAR_0358
Mycobacterium
MPRTADDSWDIATSVGATAVMVALARAAETASETPLIRDQFAEPLVSTPELAAVREQVAAWWAQTDDDDDPDFTVDSQQMTDYLAVRTHFFDSYFIDAVAAGIRQVVILAAGLDSRAYRLDWPGGTTVYEIDLPKVLDYKEHTLARHGAAPVAALRAVPVDLRHDWPQALRDAGFQTSLPTAWLAEGLLPFLPAAAQHALFTAIDANSATGSRVAVEMFGVDEDARRAAEERAQRWARQRAKRQARGQDTSFDPFDLWFDDEGQPDPADWFAAHGWTTDSVQAGAEALRLGRTAHSQEGPFVNRFVTAGKP
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
B2HLS6
Q3Y8M6
TPM_PENAT
Tropomyosin Pen a 1
Penaeus
MDAIKKKMQAMKLEKDNAMDRADTLEQQNKEANNRAEKSEEEVHNLQKRMQQLENDLDQVQESLLKANIQLVEKDKALSNAEGEVAALNRRIQLLEEDLERSEERLNTATTKLAEASQAADESERMRKVLENRSLSDEERMDALENQLKEARFLAEEADRKYDEVARKLAMVEADLERAEERAETGESKIVELEEELRVVGNNLKSLEVSEEKANQREEAYKEQIKTLTNKLKAAEARAEFAERSVQKLQKEVDRLEDELVNEKEKYKSITDELDQTFSELSGY
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Q3Y8M6
Q8TCW7
ZPLD1_HUMAN
Zona pellucida-like domain-containing protein 1, secreted form
Homo
MEQIWLLLLLTIRVLPGSAQFNGYNCDANLHSRFPAERDISVYCGVQAITMKINFCTVLFSGYSETDLALNGRHGDSHCRGFINNNTFPAVVIFIINLSTLEGCGNNLVVSTIPGVSAYGNATSVQVGNISGYIDTPDPPTIISYLPGLLYKFSCSYPLEYLVNNTQLASSSAAISVRENNGTFVSTLNLLLYNDSTYNQQLIIPSIGLPLKTKVFAAVQATNLDGRWNVLMDYCYTTPSGNPNDDIRYDLFLSCDKDPQTTVIENGRSQRGRFSFEVFRFVKHKNQKMSTVFLHCVTKLCRADDCPFLMPICSHRERRDAGRRTTWSPQSSSGSAVLSAGPIITRSDETPTNNSQLGSPSMPPFQLNAITSALISGMVILGVTSFSLLLCSLALLHRKGPTSLVLNGIRNPVFD
Glycoprotein which is a component of the gelatinous extracellular matrix in the cupulae of the vestibular organ.
Q8TCW7
Q8TXJ5
TRPD_METKA
Anthranilate phosphoribosyltransferase
Methanopyrus
MSVLERIIRGSDLDREEARDLMCRIVGGELSDVEVAGILVALRCKGYTSEELVGFVDGMMEHAVKVDPDVERLVDTAGTGGDELDTFNASTLAGLTAAAAGVPVAKHGNRSVTSECGSADILEALGVNIEADPDTVKRCIEEVGFGFMFAPKFHPAMKNVMPVRRKLGIRTVFNVLGPLTNPARERVTGQVIGVYSENLLDLVAGALAELGVRRGLVVYGLDGVDELSVTCENEVVYVDDGEVTDRDTVAPEDVGLDRADPKDVAGADPETSAEEARKILGGELPVDHPKVQMTAFNAGAALYVGEAVDSLEKGIQRALDVLEEGRALEVLEKVVDLSS
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q8TXJ5
Q9PL12
TRMD_CHLMU
tRNA [GM37] methyltransferase
Chlamydia
MEIDILSLFPDYFTSPLQATILGRAIKQGALSIRSRDIREFGLGKWKQVDDAPYSGEGMLLMAEPVVQAIRSVKREKSKVVYLSPQGQLLSAKKSRELSLCPHLILLCGHYEGIDERALASEVDEEISIGDYVLTNGCAAALVLVDALARFIPGVLGNQESAECDSLENGLLEGPHYTRPRVFEGVQVPEILFCGDHQRIANWRKKVSLERTRERRPDLYLQYFYGDRAFWGAQEDPLKMRETSPQAFSVVLEVKDLRKAKKFYSRMFGKEHWDGDKLLLGEKTSLYLQQTNERRGATKVFVELETEDGFVRFLRRWEMLGGQLGEVGMGNLPLRQVFDLDGHIWVVSCVQK
Specifically methylates guanosine-37 in various tRNAs.
Q9PL12
Q95K52
ZN283_MACFA
Zinc finger protein 283
Macaca
MGSLRHAWFNTSFSFPSSGFSGFCASPIEESHGALISSCNSRTMTDGLVTFRDVAIDFSQEEWECLDPAQRDLYVDVMLENYSNLVSLDLESTTYETKKIFSEKDIFEINFSQWEMKEKSKTLGLEASIFRNNWKCKSIFKGLKGCQEGYFSQMIISYEEIPSYRKSKSLTPHQSIHNTEKPYVYKERVNACSHGSKLVQHKRTHTAEKHFECKECGKNYLSAYQLNVHQRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHIGVKSYKCKECGKAFFWGSSLAKHEIIHTGEKPYQCKECGKAFSRGYQLTQHQKIHTGKKPYECKICGKAFCWGYQLTRHQIFHTGEKPYECKECGKAFNCGSSLIQHARIHTGEKPYECKECGKAFSRGYHLSQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHTGEKSHECKECGKNFCSGYQLTRHQVFHTGEKPYECKECGKAFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGEKPFKCKECGKAFSWGSSLIKHERVHTNEKTYGCKDCGKAFGSGYQLSVHQRFHTGEKLYQCKEFGKTFTHGSKLVHERTCNDKPYKYKECGEAFLWTTYSNEKIDTDETL
May be involved in transcriptional regulation.
Q95K52
P53781
TTP_BOVIN
Zinc finger protein 36
Bos
MDLAAIYKSLLSLSPELPSDLGETESSTSWASSGPWSLSSSDSSLPEVAARLPGRSTSLVEGRSCGWVPPPPGFAPLAPRPSSDWSPSPTSPTATPTTSSRYKTELCRTFSESGRCRYGAKCQFAHGLGELRQASRHPKYKTELCHKFYLQGRCPYGSRCHFIHNPSEDLAAPGHPHVLRQSISFSGLPSGRRTSPPPASLAGPSVSSWSFSPSSSPPPPPGDLLLSPSAFSAAPGHLCRRDPTPACCPSCRRATPNSVWGPVGGLARSPSAHSLGSDPDEYASSGTSLGGSDSPVFEAGVFGPPQPPAAPRRLPIFNRISVSE
Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. Binds to 3'-UTR ARE of numerous mRNAs. Binds also to ARE of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages. Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA. Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs. May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro. Involved in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing. Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells.
P53781
P42660
VCP_AEDAE
Vitellogenic carboxypeptidase
Stegomyia
MVKFHLLVLIAFTCYTCSDATLWNPYKKLMRGSASPRRPGESGEPLFLTPLLQDGKIEEARNKARVNHPMLSSVESYSGFMTVDAKHNSNLFFWYVPAKNNREQAPILVWLQGGPGASSLFGMFEENGPFHIHRNKSVKQREYSWHQNHHMIYIDNPVGTGFSFTDSDEGYSTNEEHVGENLMKFIQQFFVLFPNLLKHPFYISGESYGGKFVPAFGYAIHNSQSQPKINLQGLAIGDGYTDPLNQLNYGEYLYELGLIDLNGRKKFDEDTAAAIACAERKDMKCANRLIQGLFDGLDGQESYFKKVTGFSSYYNFIKGDEESKQDSVLMEFLSNPEVRKGIHVGELPFHDSDGHNKVAEMLSEDTLDTVAPWVSKLLSHYRVLFYNGQLDIICAYPMTVDFLMKMPFDGDSEYKRANREIYRVDGEIAGYKKRAGRLQEVLIRNAGHMVPRDQPKWAFDMITSFTHKNYL
May play a role in activating hydrolytic enzymes that are involved in the degradation of yolk proteins in developing embryos or may function as an exopeptidase in the degradation of vitellogenin.
P42660
A0RYD1
TRM56_CENSY
tRNA ribose 2'-O-methyltransferase aTrm56
Cenarchaeum
MRIEVLRIGQRAVRDDRVTTHAALVARAFGAERIFMEEVNPQVRDTLADVSSTWGGGFEVELIDSWRALLRSKKGSASIVHLTMYGETIDAAIGSLRRKEKILAVVGAGKVPRDVYELADYNVSIGGQPHSEISALAVFLDRLQEGRQLSKGYGDARRKVLPMRRGKHVLEGEPE
Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.
A0RYD1
Q794W0
YYCH_BACSU
Two-component system WalR/WalK regulatory protein YycH
Bacillus
MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVRVKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISDQYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFNETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLLPNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYNNRNVLTDGISRLDVNLSQRQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQIPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLLSKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGANSGVE
Together with YycI, regulates the activity of the two-component system WalR/WalK.
Q794W0
P85505
TXHM1_HERML
Neurotoxin Hm-1
Heriaeus
GCIPYGKTCEFWSGPWCCAGKCKLNVWSMTLSCTRNF
Blocks the Nav1.2/SCN2A, Nav1.4/SCN4A, and Nav1.6/SCN8A sodium channels. Reduces the peak amplitude of the sodium current and negatively shifts the steady-state inactivation process. Does not shift the threshold potential of activation or the voltage corresponding to maximal current. Does not change the reversal potential of the sodium current. May act on site 1 of the receptor.
P85505
Q9P2J2
TUTLA_HUMAN
Immunoglobulin superfamily member 9A
Homo
MVWCLGLAVLSLVISQGADGRGKPEVVSVVGRAGESVVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVGRVRLQKGASLQIEGLRVEDQGWYECRVFFLDQHIPEDDFANGSWVHLTVNSPPQFQETPPAVLEVQELEPVTLRCVARGSPLPHVTWKLRGKDLGQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPKNSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLRLLATQPDDAGCYTCVPSNGLLHPPSASAYLTVLYPAQVTAMPPETPLPIGMPGVIRCPVRANPPLLFVSWTKDGKALQLDKFPGWSQGTEGSLIIALGNEDALGEYSCTPYNSLGTAGPSPVTRVLLKAPPAFIERPKEEYFQEVGRELLIPCSAQGDPPPVVSWTKVGRGLQGQAQVDSNSSLILRPLTKEAHGHWECSASNAVARVATSTNVYVLGTSPHVVTNVSVVALPKGANVSWEPGFDGGYLQRFSVWYTPLAKRPDRMHHDWVSLAVPVGAAHLLVPGLQPHTQYQFSVLAQNKLGSGPFSEIVLSAPEGLPTTPAAPGLPPTEIPPPLSPPRGLVAVRTPRGVLLHWDPPELVPKRLDGYVLEGRQGSQGWEVLDPAVAGTETELLVPGLIKDVLYEFRLVAFAGSFVSDPSNTANVSTSGLEVYPSRTQLPGLLPQPVLAGVVGGVCFLGVAVLVSILAGCLLNRRRAARRRRKRLRQDPPLIFSPTGKSAAPSALGSGSPDSVAKLKLQGSPVPSLRQSLLWGDPAGTPSPHPDPPSSRGPLPLEPICRGPDGRFVMGPTVAAPQERSGREQAEPRTPAQRLARSFDCSSSSPSGAPQPLCIEDISPVAPPPAAPPSPLPGPGPLLQYLSLPFFREMNVDGDWPPLEEPSPAAPPDYMDTRRCPTSSFLRSPETPPVSPRESLPGAVVGAGATAEPPYTALADWTLRERLLPGLLPAAPRGSLTSQSSGRGSASFLRPPSTAPSAGGSYLSPAPGDTSSWASGPERWPRREHVVTVSKRRNTSVDENYEWDSEFPGDMELLETLHLGLASSRLRPEAEPELGVKTPEEGCLLNTAHVTGPEARCAALREEFLAFRRRRDATRARLPAYRQPVPHPEQATLL
Functions in dendrite outgrowth and synapse maturation.
Q9P2J2
Q21DB1
TSAD_RHOPB
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Rhodopseudomonas
MATDTASLVLGIETTCDETAAAVVERRSDGSGRILSNIVHSQIEDHAPFGGVVPEIAARAHVDLLDGIIARAMQQAGLGFKDLSGVAAAAGPGLIGGVIVGLTTGKAIALVHDTPLIAVNHLEAHALTPRLTDALQFPYCLFLASGGHTQIVAVLGVGNYVRLGTTVDDAMGEAFDKVAKMLGLPYPGGPQVERAAAAGDAARFAFPRPMLGRADANFSLSGLKTAVRNEASRLSPLEPQDVNDLCAGFQAAALESTADRLHVGLRIFRERFGAPHALVAAGGVAANQAIRGALQQVALAAGTQFMIPPPALCTDNGAMIAWAGAERLALGLTDSLEFAPRARWLLDANVITPAQFANTRAGF
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
Q21DB1
A0Q5Q7
UVRC_FRATN
Excinuclease ABC subunit C
Francisella
MIVDNSKDFDLKSFLANLTTHSGVYRMLDKHGEIIYVGKAKNLKNRVNSYFSKGAKDSKTLMMVEQIARIEITITPSDYEAYLLENNLIKQHRPKYNILFKDDKSYPYLVISRDKFPRVSFYRGKSAYKKGQCFGPYVSISSVKNTLNTIQKIFPIRQCENSYYKSRVRPCLQYQIKRCLAPCVGLVSQQQYDEQLAILKKFLAGKFSTVLEEISAKMYQASEDMEYEKAQVYRDQLVVLRKLQQQQIVDIQEDKTFDVIGIYMQDSYASIALLQIQNGDVVADRHWSIDAKGQDKTSIMHAFLSHFYLGDEIRNIWPKNIILSKVEFADITDLMNSISQKIGQAINWIIAPAADNLKWLKLAEVNARQKLNIYTSSKSQYQKRLESLKEFLELEKDIKRIECFDISHFQGEATIASCVVYTDEGEDRKSHRRYNIKDIKAGDDYAAIYQAVSRRVSSGLEADNLPDVMIIDGGKGQIHQAEAVFREFGIQDKVQLVSLGKGVERISGKEKIYKGFDDTEYTLDEHNPGFLLLRQVRDSAHDHAIKGQRKKVSANRQSSIIEEIEGVGPKRRKALIMYFGGWQELSRASVDEIAKVKGISKKLAQEIWECFH
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A0Q5Q7
Q822J3
TAL_CHLCV
Transaldolase
Chlamydia
MSSQFEQLKLLSVLVCDTGDPELVKTSGSQDATTNPSLILKVAQEPKYQELLTEAIAWGIRQNGDDIQTLTFVLDKIQVNFGLEILKCIPGRVSLEIDARLSFNTEAMIQRAIFLSELFAATGGDKKRLLVKIPGTWEGIRAVEVLEKQGIACNVTLIFNLIQAIAAAKANATLISPFVGRIYDWWIAAYGDEGYSIDADPGVASVSNIYTYYKKFDIPTQIMAASFRSKEQVLALAGCDLLTVSPKLLDELKKDQSPVAKKLDVAAAKKLDVQPVELTESVFRFLMNEDAMATEKLAEGIRIFSGDTQILEAAVTEFIKQIAAQDA
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Q822J3
B1M3X4
UREG1_METRJ
Urease accessory protein UreG 1
Methylobacterium
MTSTNGPLRVGIGGPVGSGKTALMEQLCKRFRDRYEICAITNDIYTKEDARILTVAGALPEERILGVETGGCPHTAIREDASINLAAVAEMSRRFPKLDLVLIESGGDNLAATFSPELADITLYVIDVAGGEKIPRKGGPGITRSDLLIVNKTDLAPLVGADLSVMESDTQRMRGTRPYVFASLREGTGADAVARFVEEAGGLGR
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
B1M3X4
Q21XE6
UPPP_ALBFT
Undecaprenyl pyrophosphate phosphatase
Rhodoferax
MDIVLLIKAAIMGLVEGLTEFLPISSTGHLILAGTLLGFDNEVGKVFDIAIQTGAIFAVILVYWQKIRDTLVALPTEKQAQRFSLNVLIAFVPAVVLGLLFGKAIKAHLFTPVVVASTFIIGGFIILWAERRQEKNPAAVRIHDVESMTPMDALKVGLAQCLAMIPGTSRSGATIIGGMLLGLSRKAATDFSFYLAIPTLIGAGVYSLFKERALLSMADLPTFAVGLVVSFFSAWLCIRWLLRYIASHSFVGFAYYRIVFGVVVLATAWSGAVTWAA
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q21XE6
P12058
TRAL_SALTI
Protein TraL
Salmonella
MEGNDLDKYRFPKTLSEQNRIIGLPLDEAIPAAVVLLWGFFTKKYLFSLIIAAVIWQLIRAAKCGKSSRWLYNWCYWYLPTELFRVVYRVIPDSSFRKWIK
Membrane protein involved in F pilin formation.
P12058
P10858
YADA_YERPS
Type 5 secretion system autotransporter YadA
Yersinia
MTKDFKISVSAALISALFSSPYAFAEEPEDGNDGIPRLSAVQISPNVDPKLGVGLYPAKPILRQENPKLPPRGPQGPEKKRARLAEAIQPQVLGGLDARAKGIHSIAIGATAEAAKPAAVAVGAGSIATGVNSVAIGPLSKALGDSAVTYGASSTAQKDGVAIGARASASDTGVAVGFNSKVDAQNSVAIGHSSHVAADHGYSIAIGDLSKTDRENSVSIGHESLNRQLTHLAAGTKDNDAVNVAQLKKEMAETLENARKETLAQSNDVLDAAKKHSNSVARTTLETAEEHANKKSAEALVSAKVYADSNSSHTLKTANSYTDVTVSSSTKKAISESNQYTDHKFSQLDNRLDKLDKRVDKGLASSAALNSLFQPYGVGKVNFTAGVGGYRSSQALAIGSGYRVNESVALKAGVAYAGSSNVMYNASFNIEW
Collagen-binding outer membrane protein forming a fibrillar matrix on the bacterial cell surface. Promotes attachment to eukaryotic cells and after invasion, is the major adhesin in infected tissue. Constitutes an alternative uptake pathway under conditions in which invasin synthesis is repressed.
P10858
Q7SIC9
TKTC_MAIZE
Transketolase, chloroplastic
Zea
GAVETLQGKAATGELLEKSVNTIRFLAIDAVEKANSGHPGLPMGCAPMGHVLYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLQYALLHLAGYDSVKEEDLKQFRQWGSRTPGHPENFETPGVEVTTGPLGQGIANAVGLALAEKHLAARFNKPDSEIVDHYTYVILGDGCQMEGIANEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTEDVSTRFEALGWHTIWVKNGNTGYDDIRAAIKEAKAVTDKPTLIKVTTTIGFGSPNKANSYSVHGSALGAKEVEATRQNLGWPYDTFFVPEDVKSHWSRHTPEGAALEADWNAKFAEYEKKYADDAATLKSIITGELPTGWVDALPKYTPESPGDATRNLSQQCLNALANVVPGLIGGSADLASSNMTLLKMFGDFQKDTAEERNVRFGVREHGMGAICNGIALHSPGFVPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHLVSFRAMPNILMLRPADGNETAGAYKVAVLNRKRPSILALSRQKLPHLPGTSIEGVEKGGYTISDNSTGNKPDLIVMGTGSELEIAAKAADELRKEGKTVRVVSFVSWELFDEQSDEYKESVLPAAVTARISIEAGSTLGWQKYVGAQGKAIGIDKFGASAPAGTIYKEYGITVESIIAAAKSF
Catalyzes the reversible transfer of a two-carbon ketol group from fructose-6-phosphate or sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate to yield xylulose-5-phosphate and erythrose-4-phosphate or ribose-5-phosphate, respectively.
Q7SIC9
Q5E4I0
TORD_ALIF1
Chaperone protein TorD
Aliivibrio
MNELTAFNEQRAEIYWWLSSLLSAELTTEQLEQYGSFEVRTFLSNLAETPELSDSVNALIEKLNAVQGREDAQLELSADFCDAFLGSDKSSALPYASMYLDKSGLLNAKPAQDMREWLTKYNIAQKAEFNEPADHIAIELDFLGNLIVMTNQQVSEDEFEAYMSAQLTFINEQLLSWTPRFNEICIERDKFGFYAAVTGLLVTFLKLDVKFLAGE
Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
Q5E4I0
Q5HBS1
TATA_EHRRW
Sec-independent protein translocase protein TatA
Ehrlichia
MALGPWQIFLILVIILVLFGAGKLPDVMSDLGKGIRNLKQELKDNKLASTEDESNL
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q5HBS1
B6DCT7
TX405_LYCSI
Toxin-like structure LSTX-C5
Lycosa
MKVLVLFSVLFLTLFSYSSTEAMDEFDSDAEEDMLSLMANEQVRAKACTPRLHDCSHDRHSCCRGELFKDVCYCFYPEGEDKTEVCSCQQPKSHKYIEKVVDKARTVVG
Enhances the high-affinity desensitization of human P2RX3 purinoceptors.
B6DCT7
Q4P235
TBB_USTMA
Beta-tubulin
Ustilago
MREIVHLQTGQCGNQVGTKFWEVLSDEHGIDHNGNYIGTSDDQLARINVYYNEASGNKYVPRAVLVDLEPGTMDSTRSGPLGGLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVIRKEAENCDMLQGFQITHSLGGGTGAGMGTLLISKIREEYPDRMMATFSVLPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYNICFKTLKLNAPTYGDLNHLVSLVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFSPLTARGSQSYRAVTIPEITQQAFDSKNMMTACDTRLGRYLTCAAYFRGKVSMKDVEDQMQSFQQKHSTQFVEWIPNNVQTAQCDIPPRGLKMSVTFIGNSTAIQDVFKRIAEQFSAMFKRKAFLHWYTGEGMDEMEFTEAESNLQDLIAEYQQYQDASALDEDIEGEYIEEEELVQE
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Q4P235
Q10424
ZIP1_SCHPO
Transcription factor zip1
Schizosaccharomyces
MDFTPNSAINHLNLKFDDVPVSDDFSKDDLAEQLNVFTNPYFLDLEPSSMLSEGYYGFVSQPSGSSNSNKQEKNVQQQNPEKISTLQQVKEEEVSNTFSAPLNATGNFSSANPASIDLAYLDLQKLLTLPDHSKETQEKTSSQRELFEQKSSVASASKDNVSSSSILQGSASSKLLPDQSARQHQVLVGQTAIPTSEASSSINNTPLQAPVSSFADQNAFTNPLSTFASPDLASVSSPSLSSYKGAQSPNANSKRTKATSAIRTAAEEDKRRRNTAASARFRIKKKLKEQQLERTAKELTEKVAILETRVRELEMENNWLKGLIRPTSNF
Mediates cell growth arrest in response to cadmium exposure, which is essential to maintain cell viability. Regulates cadmium stress specific genes.
Q10424
A0Q5K3
TDH_FRATN
L-threonine 3-dehydrogenase
Francisella
MKALAKLKKQPGIWMIDDAPIPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQNTIPVPMITGHEFAGEVVAKGDGVTSVDIGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQGAFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALSFNLTGEDVLITGAGPIGLMAVKIARFCGARRIVITDINEYRLQMARDFGATVALNVAPFKNQDELVKQMRKVMSDIGMTEGFDIGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREMFETWYLMTSMLQAGMDMNPIITHRLHIDEFQKGFEIMKSGQCGKVILDWSS
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
A0Q5K3
A4VPB2
UPP_PSEU5
UPRTase
Pseudomonas
MPIREIRHPLIRHKLGLMRRADISTKNFRELAQEVGSILTYEATSDLPLEHYNIDGWCGPVQVEKISGKKITVVPILRAGIGMLDGVLSLIPGAKVSAVGIARNEETFKAQTYLEKLVPEIEQRLAIIIDPMLATGGSMVATIDMLKKAGCKEIRALVLVAAPEGIAAVEAAHPDVLILTASIDERLDEHGYIVPGLGDAGDKIFGTKQKDI
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
A4VPB2
Q7U845
YQGF_PARMW
Putative pre-16S rRNA nuclease
Parasynechococcus marenigrum
MPRPCSVLSLDVGRKRIGLAGCDPLGITVTPIKALHRGRFDDDLPVLQQLCQDRRVQGLVVGLPLDAAGQPTAQADHCLRYGRRLAQALQLPLAWVNEHSSTWAAGERHGLKGDRSGRLDSAAAALLLDQWLREGPDLKPVQGLLGGAGAELVDGGS
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Q7U845
A8F4P7
UVRC_PSELT
Excinuclease ABC subunit C
Pseudothermotoga
MDLLHKAKLAPLLPGVYIFYGKNKEYIYVGKAKRLRNRLLSYFNRSNGKYSKKIQAIVNEAEELDYIVVSNEREALLLEANLIFNHKPKYNVMLKDAEFYPYIEITKELFPAVQIVRIRSTGGEYFGPYTDVKFVKDLIDCLQQVYQFRTCRRDMSKSTKPCMEFYMHRCAAPCTGDLEPDSYINSSIQPLRRVLNGDISETLDLIEEKMKKHAKMMDFENAAKYRDLLVKFENVMQRQGVVLEQWRNLDVIGRFKNSYAVLRIRGGHVVGKLSYELDSTKLEDFIFHYYMVGKNELPEAVILERNINFDAEIYFGRPRDKLEEELLHKARENAKNQAYTSGLRKDLLNKMVKVLNLNRYPMKIEGFDVSHLHGKLTVASVVVFFDGLPRKNEYRHYRFNSDRIDDFLTLKELVKRRYSKHELPDMIFVDGGTGQINAVVEALMEIGKECDVVGLAKQNEIVCTRFGELILPFDSPILRTLVRIRDEAHRFANSFHRKLRRKSALSSILDEIPGIGPKRKKKLIEAFGSVKNIRSATLQEIAEVLGSRKLAAEILSRL
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A8F4P7
B6I6D5
TRUD_ECOSE
tRNA-uridine isomerase D
Escherichia
MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQRRVNDKELMITAALPGSGEWGTQREALAFEKAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEIRFWLPAGSFATSVVRELINTTGDYAHIAE
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
B6I6D5
Q06466
TDA6_YEAST
Topoisomerase I damage affected protein 6
Saccharomyces
MHCVLARILLWFLIVDLSVIRALVLPPLKDYDPLEPLMKRDMAMGQRNRFKVDGQLPPILNSTDVTDDQRSLHTPGEIPSYVINHCPLVHLYSEEKYWPSDIAEYVQNFQIKDKNGNSISTHENLTLHDLKAEYHVDLFGNKTETHIPSSEVFLTSLDDFDKDPKWLLGHLPEYGTGYNSKAPAILIVVDKGNGWVDAFWFFFYPFNHGPFIMGHGPWGNHVGDWEHSLVRFYKGIPKYLWMSAHSSGTGYRYEAVEKFKKLRKRKQQDSDDGGDTILERPLIFSARGTHANYASAGQHAHDIPFFFMPLSDFTDRGPLWDPSLNFYSYTFDGKTVTPSSEREESLGLDWLHFQGGWGDQQLPARDPRQKWCVAQWKYIGGPRGPLFKKLDRLNLCGGVKKWNFWNGGCPARRLIKKAEGLDSESTDLMGDNCGVLLYRIRPKWLRGILRFLMWRGILCSLMEFFTN
Involved in vacuolar protein sorting.
Q06466
Q58E77
WD82B_XENLA
WD repeat-containing protein 82-B
Xenopus
MKLTDNVLRSFRVAKVFRENSDKINCFDFSPTGETVISSSDDDSIVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRYFPGHSKRVVSLSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGLIFAAGINSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTALKFSNDGKLILLSTNGGFLRLVDAFKGAVMHTFGGYNNSKAVTLEASFTPDSQFIMIGSEDGKIHVWNCESGMKVAVLDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD
Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation (H3K4me) via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Part of a transcription termination checkpoint that promotes transcription termination of long non-coding RNAs (lncRNAs).
Q58E77
Q65W23
YIHI_MANSM
Der GTPase-activating protein YihI
Basfia
MSRQKKSRNIVDVMPQRKSDKSQISPASYARPSKKLTRYELDAKAREDKKKKKHKGLTSGSRHSRSEQHNNQQMQEKRDPRLGSRKKVPLVVEFVNNPEKGQFIQPVQVQPAEEKVKKLDPMLELEQLENNECLNQLLDALDEGKTISAEDQKFVDECLDRIAQLMDELGIEDEEESEDDLLRTFEKIDINQFK
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
Q65W23
Q94DG6
ZIP1_ORYSJ
ZRT/IRT-like protein 1
Oryza sativa
MARTMTMRVSSLLVAVVLLAALSFQACSGHGGINDGDGQVDAPATPASSSGVRSKGLIAVKVWCLVILLVFTFAGGVSPYFYRWNESFLLLGTQFAAGVFLGTALMHFLADSTSTFKGLTTNQYPFSFMLTCVGFLLTMLSDLVIAAVARRSAAAGVSDNQVSEQQQRQQAEGAVMSRKEEEAAAVAHPAMLVRTSSFEDAVLLIVALCFHSVFEGIAIGVSASKSEAWRNLWTIGLHKIFAAVAMGIALLRMIPKRPFLMTVVYSLAFAVSSPVGVGIGIAIDATSQGRAADWTYAISMGLATGVFIYVAINHLIAKGYRPHHPTAADKPLFKFLAVLLGVAVMAVVMIWD
Zinc transporter that may mediate zinc uptake from the rhizosphere. May also transport other divalent cations.
Q94DG6
C4ZTI0
THII_ECOBW
tRNA 4-thiouridine synthase
Escherichia
MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPDVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYDKEHIINLARQIGTEDFARTMPEYCGVISKSPTVKAVKSKIEAEEEKFDFSILDKVVEEANNVDIREIAQQTEQEVVEVETVNGFGPNDVILDIRSIDEQEDKPLKVEGIDVVSLPFYKLSTKFGDLDQNKTWLLWCERGVMSRLQALYLREQGFNNVKVYRP
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
C4ZTI0
Q108P1
TNMT_PAPSO
(S)-tetrahydroprotoberberine N-methyltransferase
Papaver
MGSIDEVKKESAGETLGRLLKGEIKDEELKKLIKFQFEKRLQWGYKSSHQEQLSFNLDFIKSLKKMEMSGEIETMNKETYELPSEFLEAVFGKTVKQSMCYFTHESATIDEAEEAAHELYCERAQIKDGQTVLDIGCGQGGLVLYIAQKYKNCHVTGLTNSKAQVNYLLKQAEKLGLTNVDAILADVTQYESDKTYDRLLMIEAIEHMKNLQLFMKKLSTWMTKESLLFVDHVCHKTFAHFFEAVDEDDWYSGFIFPPGCATILAANSLLYFQDDVSVVDHWVVNGMHMARSVDIWRKALDKNMEAAKEILLPGLGGSHETVNGVVTHIRTFCMGGYEQFSMNNGDEWMVAQLLFKKK
Involved in the biosynthesis of protopine and benzophenanthridine alkaloids. Catalyzes the conversion of the protoberberine alkaloids stylopine, canadine, and tetrahydropalmatine to their corresponding N-methylated derivatives. No activity with dimethoxytetrahydroisoquinoline, methylisoquinolinediol, norlaudanosoline, (R,S)-tetrahydroxyberbine, (S)-scoulerine or (R,S)-pavine as substrates.
Q108P1
A3NXK5
UVRC_BURP0
Excinuclease ABC subunit C
pseudomallei group
MTSPDAPESRFEPKPILAQLPHLPGVYRYYDAQDAVLYVGKARDLKKRVSSYFTKTQLSPRIAMMITRIARIETTVTRSEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTGHRFPRMAYYRGAVDKKNQYFGPFPSAWAVRESIQILQRVFQLRTCEDSVFNNRTRPCLLHQIGRCSAPCVGAIGEEDYARDVDNASRFLLGRQGEVMGELERKMHAFAAELKFEQAAAVRNQMSSLAKVLHQQAIDVGGDSDVDILAVVAQGGRVCVNLAMVRGGRHLGDKAYFPAHVETALALAGDIEALAGEGAGDGVQAAAQPAQAPLATDADATDAAATEAKTVTAAAAARAGARTAQAAGARAAASAEGDVERRAEGETHARADAREAAALPDGAAAAQEADADVDAAPLETEVLEAFIAQHYLGNRVPPVLVVSHAPANRELIDLLVEQAGHKVAVVRQPQGQKRAWLTMAEQNARLALARLLSEQGSQQARTRSLADVLGYESDDLAQLRIECFDISHTMGEATQASCVVYHHHRMQSSEYRRYNIAGITPGDDYAAMRQVLTRRYEKMVEEAAAEASADEAAGIDGNAVHAAASAGRLPNVVLIDGGRGQVEIARQVFSELGLDISMLVGVAKGEGRKVGLETLIFADGRAPLELGKESAALMLVAQIRDEAHRFAITGMRAKRAKTRQTSRLEELEGVGAKRRQRLLARFGGLRGVVAASVDELASVEGISRALAEQIYRQLH
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
A3NXK5
B2U8Z0
UPP_RALPJ
UPRTase
Ralstonia
MKQDPRFPNLSILNHPLIQHKLTHMRDKDTSTRTFRELLREITLLMGYEITRNLPLTSRHIDTPMGPMEAPVIAGRKLAVVPVLRAGVGMSDGLVELIPSARIGHIGVYRDDQHRPVEYLVRLPDLEDRTFILCDPMVATGYSAVHAVDVMKKRGVPDENILFLALVAAPEGVEVFQKAHPGVKLFVASLDSHLDENAYIIPGLGDAGDRLFGTKN
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
B2U8Z0
P22275
TBA3_MAIZE
Alpha-3-tubulin
Zea
MRECISVHIGQAGIQVGNACWELYCLEHGIQPDGQVPGDKTAGHHDDAFSTFFSQTGAGKHVPRAIFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVEYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVSILLDNEAIYDICRRSLDIERPNYSNLNRLVSQVISSLTASLRFDGALNVDVNEFQTNLVPYPRIHFMLSSYAPVISSAKAFHEQLSVAEITSSAFEPASMMVKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQAPTVVPGADLAKVQRAVCMISNSTSVVEVFSRINSKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVAAEGGSDDGDEEEEY
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
P22275
Q3K9H0
TAL_PSEPF
Transaldolase
Pseudomonas
MTSKLEQLKQFTTVVADTGDFEAIARVKPVDATTNPSLLLKAAAIPAYAELLNASVRDCKGDVGLASDRFGVAVGQEILKVIPGRISTEVDARLSFDQDAVLKRAHRLIELYDKAGVGRDRVLIKIASTWEGIRAAEILEKEGIQTNLTLLFSFAQAAACADAGVFLISPFVGRIYDWYKKANGNDYTGADDPGVQSVTRIYNYYKANDYKTVVMGASFRNLSQIEQLAGCDRLTISPDLIEKLAADTGKLERKLAPGHAGEARLSLNEAQFRWLSNEDAMATEKLAEGIRQFARDQEKLEALLQAKL
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.
Q3K9H0
A0M5T6
UPPP_GRAFK
Undecaprenyl pyrophosphate phosphatase
Gramella
MDIFDAIVLGIIQGLTEFLPVSSSGHLELGKAILGDTSLPEESLLFTVVLHFATALSTLVVFRKDVFEIFSGLLKFKWNEETQFSLKIIISMLPAVIVGLLFEEQLEALFGGNILFVGFMLLITALLLWLADKAKDTGKKVSYRNAFIIGVSQAIAMLPGISRSGATISTSVLLGNDKTKAARFSFLMVVPLIFGKIAKDLMSGELMASSTDFSILATGFIAAFLAGLVACTWMISLVKKSKLSWFAIYCFVVGLAAIIFAYAQ
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
A0M5T6
A0JYP1
THIE_ARTS2
Thiamine-phosphate pyrophosphorylase
Arthrobacter
MTEQALLTDARLYLCTDARTDRGDFADFVDAAYAGGVDIIQLRDKGLEAAEELELLEVLETAARRHGRLWSVNDRADIASLSGAPVLHVGQKDLPLASARKFLGGEAVIGLSTHSHGQIDAAIAASRGAGGLDYFCVGPVWATPTKPGRAAVGLELVRYAAEAAGKTTAKTTGGAAGPTVDGPRLPWFAIGGIDLGNVEQVAAAGAERIVVVRAITEADDPAAAARSLLAALDAGAS
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
A0JYP1
P29172
TAU_BOVIN
Paired helical filament-tau
Bos
MAEPRQEFDVMEDHAQGDYTLQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPTAEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMVSKGKDGTGPDDKKTKGADGKPGTKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATMQVQKKPPPAGAKSERGESGKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
P29172
Q0HMG7
Y670_SHESM
Nucleotide-binding protein Shewmr4_0670
Shewanella
MKLVIVSGRSGSGKSVALRVLEDLGYYCVDNLPLPLIGSLLEQLKGSNDLVAISVDVRNLPEQDKVLVKQLTSLPEGTELTSFFLNSSDKVLLKRYSETRRLHPLSKSRVSLQEAIKLEGKLLEPLSQQMDHYIDTSNLNIYELSDQVRQILLGSVDKELVINFESFGFKHGMPTEADFMFDVRFLPNPHWEPELRPLTGLDEPVAEFLNRQPLVNKFIWQIENLLETWLPHLERNNRSYLTIAIGCTGGQHRSVYVAEQLAKRFSNGKHKVNARHRELSHAKA
Displays ATPase and GTPase activities.
Q0HMG7
Q4P0L3
XY11A_USTMA
1,4-beta-D-xylan xylanohydrolase 11A
Ustilago
MKFATVLAFATAAGAAFASPLASSETTEAGQLSKRQSINYVQNYNGNAANFKYDQHAGTYSTRWTNPPDFVVGLGWSPGNSYRTIKFSGSYSSSSSSYSAVYGWLNNPLTEYYVVENYSYDPCSNSGAQVVGSVTSDGSNYKICKHTQYDQPSIQGTKTFGQYFSVRANKRNSGSVTLSKHFNAWKQHGFANGAANPDFNYQVFATEAFGGTGSASMSVSG
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
Q4P0L3
B1MZE7
TRMB_LEUCK
tRNA(m7G46)-methyltransferase
Leuconostoc
MHLRAKPWATDWLAAHSDIVITQGRATEQIGQWQKLFAKAQPIHVEIGSGKGQFILGMALAHPEINYIGMEIQETAVAIAARKSFDQVGELPNLRYIYGNGNGVETYFEKAEVEKIYLNFSDPWPKTRHESRRLTYKTFLQSYEAVLPEHGEVEFKTDNRHLFEYSIVSFMNYGMRWATTDFTLDLHADAEKVIGNVETEYEQKFMAKGQPIYKIKAHF
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
B1MZE7
Q02F45
THIC_PSEAB
Thiamine biosynthesis protein ThiC
Pseudomonas
MSATQKNNITRLEQLDRQSTQPFPNSRKVYLTGSRPDIRVPVREISLADTPTAFGGEKNPPVFVYDTSGPYTDPEVRIDLRKGLPDVRSRWIDERGDTEILPGLTSEFGQARLADASLDALRFAHVRTPRRAKPGANVSQMHYAKKGIITPEMEYIAIRENMKLQEARAAGLLDQQHPGHSFGANTPKEITPEFVREEVARGRAIIPANINHTELEPMIIGRNFLVKINGNIGNSALGSSIEEEVEKLTWGIRWGADTVMDLSTGKHIHETREWILRNSPVPIGTVPIYQALEKVNGVAEDLTWEIFRDTLIEQAEQGVDYFTIHAGVLLRYVPLTAKRVTGIVSRGGSIMAKWCLAHHQENFLYTHFEEICEIMKAYDVSFSLGDGLRPGSVADANDAAQFGELETLGELTKIAWKHDVQVMIEGPGHVPMQLIKENMDKQLECCDEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWFGCAMLCYVTPKEHLGLPNKDDVKTGIITYKIAAHAADLAKGHPGAQIRDNALSKARFEFRWEDQFNLGLDPDTARAFHDETLPKDSAKVAHFCSMCGPKFCSMKITQEVRDYAKENGLSDESKAIEAGFQEQAARFKDEGSVIYRQV
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Q02F45
Q4AA71
TMCAL_MESHJ
tRNA(Met) cytidine acetate ligase
Mesomycoplasma
MAIAIIAEYNPFHNGHIYQLEYTKKNFPNDKIYIILSGNFTQRGEISLADFKTKSKIALKYGADFIIKLPFEYATQAAHIFAKGAIKIVNQHKIDKIIFGSESNDVENLYKLANLWNQNQEAYNAFLKYALKLGYSFPKASAFALEEISGQKIVFPNDILGFEYIKQIVANNYPIRAYTLKRSEEFSLKNPEPNIASATYLRQLVNENKSISRFSPMKFIHPVCSLANLYPEFQKIVRETSPENLAKIWLISEGIENLFKKHINEPNFEKFLNAVNSRRYTNSRIKRAMVYILFRIEDPSQFDEEKIQLDCWKNQGF
Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
Q4AA71
B0TYR8
TDH_FRAP2
L-threonine 3-dehydrogenase
Francisella
MKALAKLKKEPGIWMIDDAPMPEYGYNDVLIKIKKTAICGTDLHIYNWDKWSQATIPVPMITGHEFAGEVVAKGNGVTSVDVGDRVSGEGHLVCGQCRNCRAGKRHLCRKTIGIGVNVQGAFAEYLVMPAVNVFKIPDSISDDIASTFDPMGNAIHTALSFNLTGEDVLITGAGPIGLMAVKIARFCGARRIVITDINKYRLQMARDFGATVAVNVSEFQNQQQLTAQMRKVMSEIGMTEGFDVGLEMSGINSAISMMLDVMNHGGKLSLLGISAGDISVDWGAILFKGLTLKGIYGREMFETWYLMTSMLQAGMDMEPIITHRLHIDDYQKGFEIMKSGQCGKVILDWSR
Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate.
B0TYR8
Q8IWU4
ZNT8_HUMAN
Solute carrier family 30 member 8
Homo
MEFLERTYLVNDKAAKMYAFTLESVELQQKPVNKDQCPRERPEELESGGMYHCHSGSKPTEKGANEYAYAKWKLCSASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDYQIQATVMIIVSSCAVAANIVLTVVLHQRCLGHNHKEVQANASVRAAFVHALGDLFQSISVLISALIIYFKPEYKIADPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYSGVKELILAVDGVLSVHSLHIWSLTMNQVILSAHVATAASRDSQVVRREIAKALSKSFTMHSLTIQMESPVDQDPDCLFCEDPCD
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
Q8IWU4
Q72D63
XGPT_DESVH
Xanthine phosphoribosyltransferase
Desulfovibrio
MSTADRYRKVFPVTWEQLHRDAKALSWRLLEKGPYKGIIAIARGGLVPAAVIARELDIHLVETICISSYQWQEQTSSHKVLKTVEGRGEGWLIIDDLADTGGTARLVREMLPEAHFATVYAKPAGRPLVDTFITEVSQDTWILFPWDSEVQYVVPLVNQPQQS
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.
Q72D63
B5F4F0
TREA_SALA4
Alpha,alpha-trehalose glucohydrolase
Salmonella
MIPPEIRRSVLLQKAIKLALAGTLLTFASFSATAADPSSDTETPQPPDILLGPLFNDVQNAKLFPDQKTFADAIPNSDPLMILADYRMQRNQSGFDLRHFVDVNFTLPKAGEKYVPPAGQSLREHIDGLWPVLTRSTKNVEKWDSLLPLPESYVVPGGRFREIYYWDSYFTMLGLAESGHWDKVADMVANFGYEIDAWGHIPNGNRTYYLSRSQPPFFAFMVELLAQHEGDDALKEYLPQLQKEYAYWMEGVETLQPGQQNQRVVKLEDGSVLNRYWDDRDTPRPESWVEDIATAKSNPNRPATEIYRDLRSAAASGWDFSSRWMDNPQQLSTIRTTTIVPVDLNALLYQLEKTLARASAAAGDRAKASQYDALANARQKAIEMHLWNNKEGWYADYDLQNNKIRNQLTAAALFPLYVNAAAKDRAAKVAAAAQAHLLQPGGLATTSVKSGQQWDAPNGWAPLQWVAAEGLQNYGQDDVAMEVTWRFLTNVQHTYDREKKLVEKYDVSSTGTGGGGGEYPLQDGFGWTNGVTLKMLDLICPQEKPCDSVPSTRPASLSATPTKTPSAATQ
Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system.
B5F4F0
Q2YIT7
VIRB3_BRUA2
Type IV secretion system protein virB3
Brucella
MTTAPQESNARSAGYRGDPIFKGCTRPAMLFGVPVIPLVIVGGSIVLLSVWISMFILPLIVPIVLVMRQITQTDDQMFRLLGLKAQFRLIHFNRTGRFWRASAYSPIAFTKRKRES
The virB operon is essential for intracellular survival and is not involved in the invasion process. Constitutes a major determinant of virulence in mice.
Q2YIT7
E7FEV0
WDR81_DANRE
WD repeat-containing protein 81
Danio
MEWLAPALERDLGIDQRQTAHSQRPNELVVLVPTRWVMALRNKRVTRCAKYESFSEGEICTLLQRSQMKLPSGWTRVCIQGLRKRKLGYRFARETGCHGEGLSQDSFMTLMQGVSQSNFRNLWHEAYMTHVQPYADSVEQTPVLALDAVRQALQKLFCSNFISTDRVSPSLSPAKEKEKDCPFLSTCSAPKQSTESLCPNVLPAECLLESEEVLYVVFPYTQYTVHDIVTYSPAKLANSNAKILFILYQLLIAMRECHASGLLCGELSLLDIAVDEQLCSRLKISLAHYEKFKEYRDAVPYALQNKVPMSVSTKDNHNNGVSGQLCRNCQDELKSLVLDWVNGQVSNFQYLMELNRLAGRREGDPNYHPVLPWVVDFTVPYGRFRDLKKSKFRLNKGDKQLDFTYEMTKEALAAVSGSGGSNYPPDLGGPVVPGGPGQSDHLHVPHHISDVLSDITYYVYKARQTPKSVLCSHVRSQWEPNEYPASMERIQSWTPDECIPEFYRDPSIFRSIHPDMPDLDVPPWCNSYEEFIAVHRQLLESREVSQQLHHWIDLTFGYKLSGKEAIKAKNVCLHLVDNHTHLTSYGVVQLFDHPHPPRLALYQYAPPEPPHFGRVNVTTWQIPPLETTMDGVDGLVPEATGCESSGWSVVGRDEELEQAIEALDLSGSSSSTSASVSIPVVGSAAGKTSGETIGLVVSPSHGSFPGEATGNVTNTLGSGIRTAMLHRAASVSKKPEASNLEDFKISLPDGFKPLQPLEELEKLNTFLVKGLHSEIEHTMDLGINKKDLRSVPKVPLSFTDLFQRDMQALGVLIAEIFYSSKLRGLRPETHLRDRFQAVLKLCSTNLRDVPLPLHHALDTLLQVHKHCLKTETIIMHPQGLPFLFKYDPICEGLPPPNPWQLLSPIVSPLPFPEYFPTLHKFIFSYHSKMESINNIQGRDIVFNLWQQLETLLKGDITTEGLEILLPFVLSLMSEESTAVYAAWYLFEPVSRVLGPRNASKYLIKPLVGVYENPRCLRGRFYLYTDCFVLQLIVRLGLQVFLSSLLPHVLQVMTGFESCNTAAGTEWEGMKVLRGAAGALDEEEEEYECDDRRSSNATSSGKVGGGSGGGSGGVGVVGDQGLVDYSSGISLNDQVFLNEGEDFQNGFYVNNSASGATTVGTKQQNQSTANKDQDQESLSVGKLSDKSSASEVSIGDRASLKSADSSQDLKQASDGEDGGELEDEEETVEDREITVQRVPSLEMTLSVCTEESEATVATLEGDVMNGIVQEDGEKNMEEEETEHDPLEDSEEKEHKILLDTVCKTVRWLSAKLGPTLTSRFIARNLLRLLTSCYIGLDKHQFMLSVNEENSLECVGSVYEKKPVVGDQTARPVLECLIYIAHLYGEPVLTYQYLPYIGYLVSPPSSCRLNTRKEAGLLGAVVLTQKIIVFLSDTTLMDMLMKINQEVLLPLLDLLTSTKMGFPSGVQTRSAVCLKTLSLMALICLRIGREMVQQHMAETLSRFFQVFSLLQFLQNQIGSAPRREVAECTYLDLRIPDGAELTIELGVLEELQAVFNPEMAYASYIPFYCLIGDSGIRKLVTNHELVWSLAQSYHERASPGSPESNPVGGQRASAVGLSPSMGRQMSRSPFPAPSSTSTPLGGDILPESGTFGSHLVGNRIQVTRDTEACGSPNLSSLETWTHGRPYGSNAPPMSLATTALSSAGPSFSHSSYSWVMGPTPEDSALKQDLPRSSRSLQGNWLAYWQYEIGLNQQDSHFHFHQIRLQSFIGHSGTAKCLAPLAGEDYFLSGSKDKTVRLWPLYNHGDGTREVEPRLTYTEHRKSIFYVGQLEALQEVVSCDGTVHLWDQFTGKNIRCNEPLDGKNPITAVTTMPAPHCSVVFASADSVLRFIDPRKPGLQHEFRLAYSNLSAGLIRCLAVSPGGRTIAAGFSTGFIVLLDARTGLVLRGWPGHEGDILQMKAAEGNLLVSSSSDHTLTVWKDVEHKPLHQYRTPSDPIHAFDLYGAEIVAGTVANKIGVYSILDSTASLAGSTKLSTENFRGTLTSLSVLPTKRLLLLGSDNGAIRLLA
Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. May also be involved in maintenance of normal mitochondrial structure and organization.
E7FEV0
Q9N5D6
UNC62_CAEEL
Uncoordinated protein 62
Caenorhabditis
MSGDSKVWAHASADTWAVQNGISTYDLDTSSIKREKRDHNEQFNDGYGPPPGSASADPASYIADPAAFYNLYTNMGGAPTSTPMMHHEMGEAMKRDKESIYAHPLYPLLVLLFEKCELATSTPRDTSRDGSTSSDVCSSASFKDDLNEFVRHTQENADKQYYVPNPQLDQIMLQSIQMLRFHLLELEKVHELCDNFCNRYVVCLKGKMPLDIVGDERASSSQPPMSPGSMGHLGHSSSPSMAGGATPMHYPPPYEPQSVPLPENAGVMGGHPMEGSSMAYSMAGMAAAAASSSSSSNQAGDHPLANGGTLHSTAGASQTLLPIAVSSPSTCSSGGLRQDSTPLSGETPMGHANGNSMDSISEAGDEFSVCGSNDDGRDSVLSDSANGSQNGKRKVPKVFSKEAITKFRAWLFHNLTHPYPSEEQKKQLAKETGLTILQVNNWFINARRRIVQPMIDQNNRAGRSGQMNVCKNRRRNRSEQSPGPSPDSGSDSGANYSPDPSSLAASTAMPYPAEFYMQRTMPYGGFPSFTNPAMPFMNPMMGFQVAPTVDALSQQWVDLSAPHE
Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis . Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis . Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage . Required for multiple roles in regulating vulva development . Associates with homeobox ceh-60 to regulate gene expression, including repression of genes involved in innate immunity and activation of genes involved in vitellogenesis . Involved in lipid homeostasis, contributing to the formation of the cuticle .
Q9N5D6
Q8SR76
TCPG_ENCCU
CCT-gamma
Encephalitozoon
MQKPIPRKMYILVPDKPAQIQNESAIAAKTISSVIRTCLGPRAMQKMVLTKINSIELTNDGNAILRELDVAHPSARSLIELAKTQDDEVGDGTTSVVLLAAEILNEMTYILDRDVHPIRICKALGRALEICIKAIDGAAISLDSNEETKIKIINGSVASKICNILKVPIGNLALEAVKKVYVKEENKCDLKNNMKVEKVLGGNLMESEVVDGVLINKDIIHPQMRRVIENPRIVIIESPLEYKKGESQTNYEFSKENDFTRALEIEEEQVREMCERIIGVRPDIVVCEKGISDLALSILFENNITGLRRLKKTDISRLSKVCGARSVSRPEDLEERHVGVSCGLFEYIKYGEEYYCKFSRCAHPKACSVVIRGPTKDILDELERNFMDAVKVAKSIFISPKLCPGGGAAEMAMAHELMQSAGDNEVEAEVFSRMASALTIIPSILLENSGVFNPLEAITLLEQKHKEGSFYGVNGTTGEIVDTRDLVLEPYAVKSQCIKSAVEAVSQLLRIDGIIESKR
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.
Q8SR76
A0AM40
Y2654_LISW6
Nucleoid-associated protein lwe2654
Listeria
MRGMGNMQGMMKQMQKMQKEMAKAQADLEVQEFTGTAGGGMVTVKATGKRVITDVVINEEVVDPEDIEMLQDLVLAATNDVLKQIEDTTSQTMGKFTQGLNLPGM
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
A0AM40
Q3J767
URED_NITOC
Urease accessory protein UreD
Nitrosococcus
MKKIAVFKQMPCEAADAPPAKTDLLPLSWPAKLELGYQRVKMRTVPVLRRHQGPLRVQKHLYPEGPAVCQHMILHPPGGIAGGDTLDIQIHAGSHAWAQLTSPGAAKWYRSEVSLARQNLALSTEPGGILEWLPQETIFFAGCQTALDTTIDLAEDAKVIAWDIIALGRPASGERFNSGRIYQRFRLRRNGRLLWSERMQLLGGSRLLESPIGFAGYPVAGTLLASGELNDQQLTACRSLPIEGGRGGLSQLPGLVVARFLGEETEAARNWFIALWQELRPALLGRSVSIPRIWNT
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Q3J767
O29178
Y1087_ARCFU
Putative antitoxin AF_1087
Archaeoglobus
MPKIIEAVYENGVFKPLQKVDLKEGEKIRLRIEEGIADVIKEFSRKVDQDVLEEFLRERR
Possibly the antitoxin component of a type II toxin-antitoxin (TA) system.
O29178
Q9LZ03
TOP6A_ARATH
Protein ROOT HAIRLESS 2
Arabidopsis
MADKKKRKRSKDDEAEELPFKSILESDDVITELLKSYISSSIKAAAGAGGASSSSSKPLTLADLSLSSSCREVADLSLSSVQTEIETVIVQIARSILAGDGFSFSVPSRAASNQLYVPELDRIVLKDKSTLRPFASVSSVRKTTITTRILALIHQLCLRNIHVTKRDLFYTDVKLFQDQTQSDAVLDDVSCMLGCTRSSLNVIAAEKGVVVGRLIFSDNGDMIDCTKMGMGGKAIPPNIDRVGDMQSDAMFILLVEKDAAYMRLAEDRFYNRFPCIIVTAKGQPDVATRLFLRKMKMELKLPVLALVDSDPYGLKILSVYGCGSKNMSYDSANLTTPDIKWLGIRPSDLDKYKIPEQCRLPMTEQDIKTGKDMLEEDFVKKNPGWVEELNLMVKTKQKAEIQALSSFGFQYLSEVYLPLKLQQQDWL
Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. Involved in cell-elongation processes.
Q9LZ03
F8J4S0
TOP4A_OXYTA
Oxyopinin-4a
Oxyopes
MKISQVFIFVFLLMISVAWANEAYEEESNYLSERFDADVEEITPEFRGIRCPKSWKCKAFKQRVLKRLLAMLRQHAF
Disrupts cell membranes through the formation of pores (Probable). Has antibacterial activity against Gram-positive bacteria S.aureus (MIC=10 uM) and B.subtilis (MIC=0.5 uM) as well as Gram-negative bacteria P.fluorescens (MIC=1 uM) and E.coli (MIC=0.5 uM). Has hemolytic activity against human erythrocytes (EC(50)=7 uM).
F8J4S0
Q8K982
Y467_BUCAP
Nucleoid-associated protein BUsg_467
Buchnera
MFTKGGLGNLMKQAQQMQEKMAKVQEEIAKMEVTGEAGAGLVKVTINGAHNCRRVEVDPSLLKDDKDMLEDLAAAAFNDATRRISEVQKKKMSAISTGMQLPTGFNIPI
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q8K982
P19247
VVHA_VIBVU
Cytolysin
Vibrio
MKKMTLFTLSLLATAVQVGAQEYVPIVEKPIYITSSKIKCVLHTSGDFNATRDWCNAGASIDVRVNVAQMRSVQSATSDGFTPDAKIVRFTVDADKPGTGIHLVNELQQDHSWFQSWANRRTYIGPFASSYDLWVKPVSGYTPKKARDLPQNENKNYQHRDTYGYSIGINGKVGAEVNKDGPKVGGEVSGSFTYNYSKTLVFDTKDYRINNRSSLSDFDISFEREFGECDELRRQELGCYFTAAHWGSGWVFDKTKFNPISYSNFKPNYDVLYEAPVSETGVTDFEMGVKLNYRARFGTVLPSALFSVYGSAGSSTNSSTVKQRIRIDWNHPLFEAEAHVTLQSLSNNDLCLDVYGENGDKTVAGGSVNGWSCHGSWNQVWGLDKEERYRSRVASDRCLTVNADKTLTVEQCGANLAQKWYWEGDKLISRYVDGNNTRYLLNIVGGRNVQVTPENEANQARWKPTLQQVKL
Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined.
P19247
A8GLI7
YIHI_SERP5
Der GTPase-activating protein YihI
Serratia
MNQPSKAPRAPRSSAATPKNKKKSRAELDQEAREHKRAKKRRGLASGSRTQVESTNQKNKAAAQAKDPRIGSKVPVALVVEDKPKAKPQPKPKAEAKPKPRLTPEEELAKLENDERLDALLDRIDDGETLSAEDQKYVDQTLDRIDALMEQLGIELGDDDEEEEEKREDILKLLKGGNPKDVI
A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis.
A8GLI7
Q9A566
TRMFO_CAUVC
Folate-dependent tRNA(M-5-U54)-methyltransferase
Caulobacter
MTTNSTYQPVHVIGGGLAGSEAAWQIAQSGVPVILHEMRKDDATGKVITDAHQTDGLAEMVCSNSFRSDDWQFNAVGLLHAEMRKLGSLIMSCADQHQVPAGGALAVDRDGFSTEVTKRLSQHPLVTIVREEIAGLPPAPDGKNGWDNVIVATGPLTSPALAQAVLDLTGEGQLSFFDAIAPIIHFESINMDIAWRQSRYDKEGPGGDAAAYINCPMNKEQYEAFIDALLAGPKSEFKEWENVPYFDGCLPIEVMAERGRETLRHGPMKPVGLTNPRDPLVKAYAIVQLRQDNALGTLWNMVGFQTKLKHGVQAETFRMIPGLEDAQFARLGGLHRNTFINSPKLLDKSLRMKAQPRLRFAGQVTGVEGYVESAAMGLLTGRFAAADRKGAPIDAPPPTTALGALVEHITGGHLEAGNGPGSFQPMNINYGLLPPLEAPKVDEDGKKIPLKERGRAKKRLMSLRALKDLDAWMA
Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.
Q9A566
Q570C8
THIK5_ARATH
Peroxisomal 3-oxoacyl-CoA thiolase 5
Arabidopsis
MERAMERQKILLRHLNPVSSSNSSLKHEPSLLSPVNCVSEVSPMAAFGDDIVIVAAYRTAICKARRGGFKDTLPDDLLASVLKAVVERTSLDPSEVGDIVVGTVIAPGSQRAMECRVAAYFAGFPDSVPVRTVNRQCSSGLQAVADVAASIRAGYYDIGIGAGVESMSTDHIPGGGFHGSNPRAQDFPKARDCLLPMGITSENVAERFGVTREEQDMAAVESHKRAAAAIASGKLKDEIIPVATKIVDPETKAEKAIVVSVDDGVRPNSNMADLAKLKTVFKQNGSTTAGNASQISDGAGAVLLMKRSLAMKKGLPILGVFRSFAVTGVEPSVMGIGPAVAIPAATKLAGLNVSDIDLFEINEAFASQYVYSCKKLELDMEKVNVNGGAIAIGHPLGATGARCVATLLHEMKRRGKDCRFGVISMCIGTGMGAAAVFERGDSVDNLSNARVANGDSH
Probably involved in long chain fatty-acid beta-oxidation prior to gluconeogenesis during germination and subsequent seedling growth. Involved in systemic jasmonic acid (JA) biosynthesis after wounding and may be during senescence.
Q570C8
B8IZH6
UPP_DESDA
UPRTase
Desulfovibrio
MAVYVVDHPLVRHKIGILRMESTSTSEFRSVSNEVARLLIYEATKGFRTEKHTVQGWAGPVEIEAISGKKVTVVPILRAGLGLMDGVLDMIPGAKISVVGLYRNEETLEPVEYYVKLASDMDQRLAIILDPMLATGGSLIATIELLKRHGCRQICSLNLVCAPEGIAKVEAAHPDVDIYTAAIDDHLNEQGYIIPGLGDAGDRIFGTK
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
B8IZH6
P36512
UDB13_RABIT
EGT10
Oryctolagus
MPVKCISVLLLLLQLSCCFSSGSCGKVLVWPMEFSHWMNMKTILDALVQQGHEVTVLRSSASIVIGSNNESGIKFETFHTSYRKDEIENFFMDWFYKMIYNVSIESYWETFSLTKMVILKYSDICEDICKEVILNKKLMTKLQESRFDVVLADPVSPGGELLAELLKIPLVYSLRGFVGYMLQKHGGGLLLPPSYVPVMMSGLGSQMTFMERVQNLLCVLYFDFWFPKFNEKRWDQFYSEVLGRPVTFLELMGKADMWLIRSYWDLEFPRPLLPNFDFIGGLHCKPAKPLPQEMEDFVQSSGEEGVVVFSLGSMISNLTEERANVIASALAQLPQKVLWRFEGKKPDMLGSNTRLYKWIPQNDLLGHPKTKAFITHGGANGVFEAIYHGIPMVGLPLFGDQLDNIVYMKAKGAAVKLNLKTMSSADLLNALKTVINDPSYKENAMTLSRIHHDQPMKPLDRAVFWIEYVMRHKGAKHLRVAAHDLTWYQYHSLDVIGFLLACVAITTYLIVKCCLLVYRYVLGAGKKKKRD
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Acts on small phenolic agents such as 2-beta-naphthol and 4-methylumbelliferone as well as bulky phenolic compounds like 2-hydroxy- and 4-hydroxybiphenyl. In contrast to 2B16 it is active toward octylgallate.
P36512
A5LGM7
TRET1_POLVA
Facilitated trehalose transporter Tret1
Polypedilum
MELNNKEDSPRHTVPFVRQITEDGKAKLEIYRPTTNPIYIYTQILAAIAVSMGSMVVGFASAYTSPALVSMQNTTITSFKVTEQEASWVGGIMPLAGLAGGIAGGPFIEYLGRKNTILATAVPFIVAWLLIAFANSIWMVLAGRALSGFCVGIASLSLPVYLGETVQPEVRGTLGLLPTAFGNIGILICFVAGKYVNWSGLAFIGSILPIPFMVLTLLIPETPRWFVTRGREERARKALQWLRGKKADVEPELKGIVKSHCEAERHASQNAIFDLMKRSNLKPLLIALGLMFFQQLSGINAVIFYTVSIFKDAGSTIDENLCTIIVGVVNFGATFFATVLIDRLGRKILLYISEVAMVITLLTLGTFFYYKNSGNDVSNIGWLPLASFVIYVIGFSSGVGPIPWLMLGEILPGKIRGSAASVATGFNWTCTFIVTKTFADIVAAIGNHGAFWFFGVICLIGLFFVIFFVPETQGKSLEEIERKMMGRVRRMSSVANMKPLSFNM
High-capacity facilitative transporter for trehalose, required to induce anhydrobiosis. Anhydrobiotic larvae can survive almost complete dehydration. Does not transport maltose, sucrose or lactose. Mediates the bidirectional transfer of trehalose. Responsible for the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source, thereby regulating trehalose levels in the hemolymph.
A5LGM7
Q67ER8
TR116_RAT
Taste receptor type 2 member 33
Rattus
MNGVLYITFTVILSVEVIIGNFGNGIIALVNIMDLAKRRKISSVDQILTALAISRIVLLWLVLVSWWLSMFYPGQWMTEGIDVIVHNVWTTLNQISLWLATSFSVFCFLKVANFSNTIFFYLKIRVKKVMTGTLIMFLLLLGLNIIVINASKTILIPEYKVNMSNSLNLKNTQISMLFPFANTLFGFIPFAVSLVTFLLLFFSLWKHQRKMHHGAQGCRDSSTKAHIRVLQTLIASILLYFVFFLSLVVKVWISLFLERMLLLLITQAAKIAFPSLHPWVLILGNAKLRKASLSALQWLRCRHKDEHRRVQRPEVHSCGSSCMP
Putative taste receptor which may play a role in the perception of bitterness.
Q67ER8
A6TEI5
TRUB_KLEP7
tRNA-uridine isomerase
Klebsiella
MSRPRRRGRDVHGVLLLDKPQGASSNDVLQKVKRIYNANRAGHTGALDPLATGMLPICLGEATKFSQYLLDSDKRYRVIAKLGQRTDTSDADGQVVEERPLTFSDEQLAAALDSFRGETQQVPSMYSALKYQGKKLYEYARQGIEVPREARPITVYELLFIRREGDELELEIHCSKGTYIRTIIDDLGEKLGCGAHVIFLRRLAVSKYPVERMVTLEQLQALVDEAAAQDIPAAQLLDPLLMPMDSPASDYPLVNIPETSAVYFKNGNPVRQSGAPLNGLVRVMESESGKFLGMGEIDDEGRVAPRRLVVEYPA
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
A6TEI5
A5N8P8
THIG_CLOK5
Thiazole synthase
Clostridium
MDNLIIGGTEVKSRLFIGTGKYSSNSIIPRILKKSKSQVITIALRRVDITSKEENMLNYINKDCILLPNTSGARNAEEAIRLARIARAAGCGNWIKIEVISDNKYLLPDNYETIKATEVLAKEGFIVLPYMNPDLMDTKRLVNAGAAAVMPLGAPIGTNRGIATKEMIRIIIDEIATPIVVDAGIGKPSQAAEAMEMGADAVLVNTAIASAGNPVLMAEAFGLAVESGRKAFLAKLGQEKLMAEASSPLTGFLR
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
A5N8P8
Q9CBG0
Y2020_MYCLE
Putative S-adenosyl-L-methionine-dependent methyltransferase ML2020
Mycobacterium
MAATPEFGSLRSDDDHWDIVSSVGYTALLVAGWRALHAVGPQPLVRDEYAKYFITASRDPYLMNLLANPGTSLNETAFPRLYGVQTRFFDDFFSSAGDTGIRQAVIVAAGLDSRAYRLKWPNGATVFEIDLPKVLEFKARVLAEQGAIPNAGRSEVAADLRADWPRALKAAGFDPQRSSAWSVEGLLPYLTNDAQSALFTRIGELCAPGSRIAVGALGSRLDRKQLAALEATHPGVNISGDVDFSALTYEPKTDSAQWLAAHGWAVEPVRNTLELQTSYGMTPPDVDVQMDSFMHSQYITATR
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Q9CBG0
Q8XK02
THIG_CLOPE
Thiazole synthase
Clostridium
MDKLIIGGIEIKNRLFVGSGKYPSNEIIKDVLEGSGSQVITLALRRVDLDNKEEDILQNIPKDVILLPNTSGATNAEEAIRIARIARAMGCGNWIKIEVISDSKYLLPDNEETIKATKVLADEGFIVLPYMCPDIYAGRRLIEAGAAAVMPLGAPIGSNRGLKTKELIQIMIDELDIPIIVDAGIGKPSQAMEAMEMGAAACLVNTAIASSEDPINMARAFKVAVEGGRLAYEAKMGRESKFGNASSPLTGFLD
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Q8XK02
A1WTL3
Y231_HALHL
Nucleoid-associated protein Hhal_0231
Halorhodospira
MKGGLGNIMKQAQKMQEDMQKAQEEIAAMEVSGEAGAGMVKVTMTGRNEVRKVEIDPSLFEDDREMVEDLVAAAVNDAVQKVQRESQERMSGMAEGMGLPPGMKLPF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
A1WTL3
Q48BQ5
UBIA_PSE14
4-HB polyprenyltransferase
Pseudomonas
MYLSLLKSLNRLSPRAWDFIQLTRIDKPIGIYLLLWPTLWAVWIAGKGSPSLKTVFIFVVGVFLMRAAGCVINDFADRKVDGHVKRTEQRPLISGKVSSREALALFAVLVGLSFVLVLFTNATTIWLSFGGLALAACYPFMKRYTYYPQVVLGAAFSWGMPMAFTAETGDLPAAAWLLYIANLLWTVGYDTYYAMVDRDDDLKIGVKSTAVLFGDADRVIILTLQGLALGCLMLAGARFELGACFYIGLLAAAGCFAWEFWSTRQRERDACFKAFLHNHWAGLAIFLGIVADYAVR
Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
Q48BQ5
Q8S8X3
YCF3_ATRBE
Photosystem I assembly protein Ycf3
Atropa
MPRSRINGNFIDQTFSIVANILLRVIPTTSGEKEAFTYYRDGMSAQSEGNYAEALQNYYEAMRLEIDPYDRSYILYNIGLIHTSNGEHTKALEYYFRALERNPFLPQAFNNMAVICHYRGEQAIQQGDSEIAEAWFDQAAEYWKQAIALTPGNYIEAHNWLKITRRFE
Essential for the assembly of the photosystem I (PSI) complex. May act as a chaperone-like factor to guide the assembly of the PSI subunits.
Q8S8X3