accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q82VS4
FTSW_NITEU
Peptidoglycan polymerase
Nitrosomonas
MMSPSTSAPHNQPIQPELDVLLVSTVLLLLGLGLVMVYSASIAIAEAKFGEGSSYYFLARQASYILAGIAVGIGCFRIPLRWWQAYSHYLLGLGILLLLVVLIPGISHEINGSRRWIPLGITSFQPSELMKLIILIFTADYVVRKAAFKDHFFKGFLPILALLTIVSLLLLMEPDLGATVVIAAIVLSIMFMNGMSLKMFFGLICLVPVLLALLIIIEPYRMDRINAIFDPWNDPFDKGYQLTHALIAFGLGEWWGVGLGSSVEKLNYLPEAHTDFMFAVLAEELGFAGVVTVISLFFFLLVRIFKVGRTAARLGDQFGSLVAQGIGVWLGLQAFINMGVNMGLLPTKGLTLPFMSYGGSSIVINSIAIAILLRIDWENRLKRRGLNA
Peptidoglycan polymerase that is essential for cell division.
Q82VS4
Q60931
VDAC3_MOUSE
Outer mitochondrial membrane protein porin 3
Mus
MCNTPTYCDLGKAAKDVFNKGYGFGMVKIDLKTKSCSGVEFSTSGHAYTDTGKASGNLETKYKVCNYGLTFTQKWNTDNTLGTEISWENKLAEGLKLTLDTIFVPNTGKKSGKLKASYRRDCFSLGSNVDIDFSGPTIYGWAVLAFEGWLAGYQMSFDTAKSKLSQNNFALGYKAADFQLHTHVNDGTEFGGSIYQKVNERIETSINLAWTAGSNNTRFGIAAKYKLDCRTSLSAKVNNASLIGLGYTQTLRPGVKLTLSALIDGKNFNAGGHKVGLGFELEA
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.
Q60931
A9MA15
OMP2B_BRUC2
Porin Omp2b
Brucella
MNIKSLLLGSAAALVAASGAQAADAIVAPEPEAVEYVRVCDAYGAGYFYIPGTETCLRVHGYVRYDVKGGDDVYTGSDRKGWDKSARFALRVSTGSETELGTLKTFTELRFNYAANNSGVDGKYGNETSSGTVMEFAYIQLGGLRVGIDESEFHTFTGYLGDVINDDVISAGSYRTGKISYTFTGGNGFSAVIALEQGGDNDGGYTGTTNYHIDGYMPDVVGGLKYAGGWGSIAGVVAYDSVIEEWAAKVRGDVNITDQFSVWLQGAYSSAATPDQNYGQWGGDWAVWGGLKYQATQKAAFNLQAAHDDWGKTAVTANVAYELVPGFTVTPEVSYTKFGGEWKNTVAEDNAWGGIVRFQRSF
Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane.
A9MA15
Q7T0V2
LTR3A_XENLA
Mitogen-activated protein kinase scaffold protein 1
Xenopus
MAEELRRFLYKKLTSVEGLHAIVVSDRDGVPVIKVANENAPEQALRPAFLSTFALATDQGSKLGLSKNKSIICYYSTYQVVQFNQLPLVVSFIASSNANTGLILSLEKELGSLFKELRQAVIS
Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, may activate the TOR signaling cascade in response to amino acids. Adapter protein that may regulate the MAP kinase cascade.
Q7T0V2
C1CTM3
COAD_STRZT
Pantetheine-phosphate adenylyltransferase
Streptococcus
MSDKIGLFTGSFDPMTNGHLDIIERASRLFDKLYVGIFFNPHKQGFLPIENRKRGLEKALGHLENVEVVASHDELVVDVAKRLGATFLVRGLRNASDLQYEASFDYYNHQLSSDIETIYLHSRPEHLYISSSGVRELLKFGQDIACYVPESILEEIRNEKKD
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
C1CTM3
B3QML1
DUT_CHLP8
dUTP pyrophosphatase
Chlorobaculum
MIKVKIVRLKEKASLPAYATAHAAGMDVSACLDAPVTLEPSSSALIPTGLAIELPEGYEAQLRPRSGLALRHLISLPNSPATIDADYRGEVGVILINHGREPFTVNHGDRIAQMVVSKVDRVAFEEVDSLSDTERGEGGFGHTGVASKAE
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
B3QML1
B2S689
RL10_BRUA1
50S ribosomal protein L10
Brucella
MDRAEKREFVAWLNGAFKESGSVVVAHYTGLTVAQMSDLRSKMRDAGGSVKVAKNRLAKIALQGTESEGIADLFTGQTVVAYANDPITAPKVAVEFAKANDKLVILGGAMGATTLNADGVKSLASLPSLDELRAKLVGMIQTPAQRLAVLTSAPAGQIARVIGAHARKNEAA
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
B2S689
Q6D8D4
SKP_PECAS
Chaperone protein Skp
Pectobacterium
MKKWLCAAGLGLVLAASASVQAADKIAVVNVSSIFQQLPQRESVGKQLENEFKGRASELQSMENDLQGKMQKLQRDGSTMKASDRSKMEKDVMAQREQFSTKAQAFEQDNRRRQTEERNKILSRIQDAVKAVATKEGYDVVIDANAVAYVANAKDITADVLKQVK
Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.
Q6D8D4
P53651
SODM_NOCAS
Superoxide dismutase [Mn]
Nocardia
MAEYTLPDLDYDYSALEPHISGQINELHHSKHHAAYVAGANTALEKLEAAREAGDHSAIFLHEKNLAFHLGGHVNHSIWWKNLSPNGGDKPVGELAAAIDDQFGSFDKFRAQFTAAANGLQGSGWAVLGYDTLGQKLLTFQLYDQQANVPLGIIPLLQVDMWEHAFYLQYKNVKADYVTAFWNVVNWADVQDRFGKAVNQGKGLIFG
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
P53651
Q06707
SWC7_YEAST
SWR1-complex protein 7
Saccharomyces
MDCPSNVVLLLLQLVLQRQQTLAHRDKSVDLQTLLKDPVIDNDVLVEFKTHKLVQLYGPQYCRDISLRGLKTMVTDIFANGIPKNAQSSGNDQPVTVVDLANYYYMQRINELQNTELPQLKEALLTRLEHMI
Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.
Q06707
P59799
FER5_AQUAE
2Fe-2S ferredoxin-5
Aquifex
MPKVIVANINAEFEGIENETIMQILYRNGIEIDSACGGHGQCTSCKVLIISGSENLYPAEFEEKDTLEENGMDPETERLSCQAKLNGKGDVVIYLP
May be involved in the assembly of iron-sulfur clusters (Isc-Fd).
P59799
A7HN78
SYS_FERNB
Seryl-tRNA(Ser/Sec) synthetase
Fervidobacterium
MIDLKLLRKDPQHFYEALKKRNYSTDIIDEIVNLDKEWRNQLNIVNNLKAKRNELSKLVARYKAEGKNQEAEEIIAESKKIGEEIAQYEGKQKELEEKMYNLALYIPNPPHESVPVGKDETENVEIRRWGEPRKFDFEPKAHWDLGPELGMLDFDRGSKLSGSRFTVMFGAIAKLERAIAQFMLDVHTKNGYIEVNVPHLVKRETITATGQLPKFSEELYTCERDDLFLIPTAEVSLAALHIDEILEENKLPKKYTAFTPCYRREAGSYGKDVRGLIRQHQFEKVELVWYTTPERSFEDLEQLTQDAERILQLLGLPYRVVTLCTGDLGFAAAKTYDIEVWLPSYNSYKEISSCSNVTDFQARRGNIRYRAKDGKLNYVHTLNGSGLAIGRTLVAIMENYQNPDGTITIPEVLRPYMGTDIIKPME
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
A7HN78
Q7SYI5
C1GTB_DANRE
Core 1 beta1,3-galactosyltransferase 1-B
Danio
MKALGARSAFYVGFLVGTCSLYLLLRQAGFTRDSGSREPGTHDKTLLEMLEEENKNWKKERSALFNLNHPHHTGEDGALADSLYKRVRILCWVMTGPDNLEKKARHVKATWSRHCNIVVFISSVDNPDFPTVGLNTKEGRDQLYWKTIRAFHYVMEKHSDEADWFLKADDDTYVIVDNLRWILARHSPEDPVYFGRRFKPYVKQGYMSGGAGYVLSKEALRRFVEGFRTKVCTHTTSVEDLAMGQCMEKIGVKAGDSRDTMQRETFHPFVPESHLTGTFPKTFWYWNYCYYPIVQGPQCCSDLAVSFHYVDASHMYLLEYYTYHLRAFGYKYRYQPPEPNVKAPEKVETRVLEQKDKVEAQEEENQSPELNDKL
Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.
Q7SYI5
Q84W27
SCP43_ARATH
Serine carboxypeptidase-like 43
Arabidopsis
MVSSRAVVMAIMVLVTVQWLVFAEGYPEEDLVARLPGQPNVGFRQFAGYVDVDSENGRSLFYYYVEAVKEPDTKPLTLWLNGGPGCSSVGGGAFTELGPFYPTGDGRGLRLNSMSWNKASNLLFVESPAGVGWSYSNRSSDYNTGDKSTVNDMLVFLLRWFNKFPELKSRDLFLTGESYAGHYIPQLADVILSYNSRSSGFKFNVKGIAIGNPLLKLDRDFAAAYEYFWSHGMISDEVRLTIMNQCDFANPKNMSNACIYAIVESSVLTEYINSYHILLDVCYPSIVQQELRLKKMNALHANRTRLPYEWTMCSNRLNYSGIDGYIDMLPSLKRIIQNQTPVWIFSGDQDSVIPLQSSRTLVRELAEDLNFKTTIPYGAWFHKEQVGGWVTEYGNLLTFATVRGAAHMVPYAEPSRALHMFSSFMNGRRLPNKPDLKSSTDD
Probable carboxypeptidase.
Q84W27
A0RVY8
RS8_CENSY
30S ribosomal protein S8
Cenarchaeum
MPATNILANLFVTLYNTEARRRGDCQVYPTSKLGVEVLGTLKKAGYIGEFEHVEDSRGGKFSVHLLAKITKCGAISPRFKVKKGEYTFWEQQYLPSYDRGMLVVTTNQGVMSHHEAAERGIGGFLIGYVY
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
A0RVY8
P50207
HXC13_MOUSE
Homeobox protein Hox-C13
Mus
MTTSLLLHPRWPESLMYVYEDSAAESGSGGGGGGGGAGGAGGGCSGASPGKAPSMDGLGGSCPASHCRDLLPHPVLARPPAPLGAPQGAVYTDIPAPEAARQCAPPPAPPTSSSATLGYGYPFGGSYYGCRLSHNVNLQQKPCAYHPGDKYPEPSGALPGDDLSSRAKEFAFYPSFASSYQAMPGYLDVSVVPGISGHPEPRHDALIPVEGYQHWALSNGWDSQVYCSKEQSQSAHLWKSPFPDVVPLQPEVSSYRRGRKKRVPYTKVQLKELEKEYAASKFITKEKRRRISATTNLSERQVTIWFQNRRVKEKKVVSKSKAPHLHST
Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes.
P50207
A4ITV2
GDPP_GEOTN
Cyclic-di-AMP phosphodiesterase GdpP
Geobacillus
MSHFYERKTYRYPSYALAALAVLMAVSLFYFQWMLGLVGLLGVGFLLYYVIWSQRSLHKELQQYISNLSYRVKKVSEEALMQMPIGILLLDEEDKIEWSNRFLAACFKEQTLIGRSLAELSEPLAAFVKKGKTDEEIIELNGKQLKVIVHRHERLLYFFDVTEHMELRRRYEIERLVLAIIFLDNYDEITQGMDDQAKSQMNSLVTSVLNRWANDYGIFLKRTSSDRFIAVLNEHILTQLEKSKFSILDEVREQTAKHQAQITLSIGIGAGVSSLPELGTLAQSSLDLALGRGGDQVAIKQGNGKVKFYGGKTNPMEKRTRVRARVISHALRELIAESDKVLIMGHKYPDMDALGAAIGILKVVQSNQKEGFLVVDAMKTDAGAQRLLEEMKKQADLWARCIKPEQALELITEDTLLIVVDTHRPSLVIEERLLYRADHIVVIDHHRRGEEFIEAPILVYMEPYASSTSELVTELLEYQPKRVKLSMLEATALLAGIVVDTKSFTLRTGSRTFDAASYLRAQGADTVLVQKLLRESVANYVKRAKLIERAAIDEHGIAIAKGDENEVHDQVLIAQTADTLLTLSGVVASFVISKRGDGTVGISARSLGDVNVQVIMERLGGGGHLTNAAAQLSDVTVGEAEQQLREAIHDYFEGGKPV
Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP) and to a much lesser extent against cyclic-di-GMP (c-di-GMP) in the DHH/DHHA1 domains. Also has ATPase activity, probably via the GGDEF domain. May monitor cellular heme or NO levels.
A4ITV2
Q4KKJ8
ENGB_PSEF5
Probable GTP-binding protein EngB
Pseudomonas
MQLKNPILGLCQQATFMLSAAKVDQCPDDEGFEVAFAGRSNAGKSSALNTLTHASLARTSKTPGRTQLLNFFKLDDDRRLVDLPGYGYAKVPIPLKQHWQRHLEAYLGSRESLKGLILMMDIRHPMTDFDLLMLDWAVASGMPMHILLTKADKLTYGAAKNTLLKVQSQIRKGWGEAVTIQLFSAPKRMGLEEAYTVLAGWMELADKGAEAEA
Necessary for normal cell division and for the maintenance of normal septation.
Q4KKJ8
A9BFZ5
IF1_PETMO
Translation initiation factor IF-1
Petrotoga
MAKKDVVVMQGYIIEALPNANFKVKLDNGHEILAHISGRMRKNFIKILPGDRVTVEVSVYDLNKGRIVKREKVNKD
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
A9BFZ5
B3QAC6
MIAB_RHOPT
tRNA-i(6)A37 methylthiotransferase
Rhodopseudomonas
MSPPRKLHIKSYGCQMNVYDAQRMVDALAPEGFVETANVDDADLVILNTCHIREKASEKVYSELGRLRVARDEAANHGRRMQIAVAGCVAQAEGEEIIRRAPVVDVVVGPQSYHNLPQLLAKAEQHGRALETEFPIEDKFGVLPQPAPDAIRARGISAFVTVQEGCDKFCTFCVVPYTRGAEMSRPVVAIVEDVKRLAENGVREVTLIGQNVNAYHGDGPDGRAWSLGRLVRRLAEIPGIVRLRYSTSHPNDVDDDLLAAHRDLPALMPFVHLPVQSGSDRILAAMNRKHTADDYRRVIDRFRSASETIAFSSDFIVGFPGETERDFSATLALVAQIGYAGAYSFKYSPRPGTPAADMVEMVPAAVMDERLEQLQQLIDQQQSAFNKAAIGRTVEVLFERAGRKPGQIVGRTAYLQPAHVMAPDSIIGKVLPVRVDSLERYSLLGELASATSRPADAMAATGA
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
B3QAC6
Q96SZ5
AEDO_HUMAN
Cysteamine dioxygenase
Homo
MPRDNMASLIQRIARQACLTFRGSGGGRGASDRDAASGPEAPMQPGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRDCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP
Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate . Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine . Catalyzes the oxidation of regulators of G-protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32) .
Q96SZ5
A5D2S5
RS15_PELTS
30S ribosomal protein S15
Pelotomaculum
MALTSEQKKNVISRYKLHDNDTGSPEVQVAILTERINSLTEHLKLHKGDHHSRRGLLKMVGQRRALLNYLRDRHYERYRALIDKLGLRK
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
A5D2S5
B2DBF0
PADC1_PHOAM
Phyllocladan-16-alpha-ol synthase
Diaporthe
MTIMDIDDHSRLRDLAVSLIRQAAEGYSPKYGYGSMSCAAYDTAWVSLVAKPFNGIKKWLFPQSFKFLLENQENDGSWGRQTSPVDRILNTAAPLLSLQRHAREPLQLHDVCEDGDLDDRIHRATLSLQRQLSDWDIASTAHVGFEIIVPALLNLLAAEGLCFSFKAQDELMKVNAAKLKRFDPEVLLYGKHKTTLLHSLEAFVGIIDFDKVVHHKVGGSFMASPSATAAYLMNASCWDDEAEDYIKNVLVNGSGRGHGAVPSAYPSSNFEYSWLLSTLLHAGFTAKDIECPELCDVAGMLENSFIEGQGTIGFARSISSDADDTAKAAFALNKLGYDVSVNEMVKEFEVKNHFQTYPSERDASLSANCNTLLALLHQKQVGAYQPQILKCVKFLTRCWWNTDGPIRDKWNQSHLYSTMLMVQALTEFQAILDQKGLPYGLNTVEMARVSICLFQGCLRTMLQQCEDGSWSHSREQTAYAVLTLGQARRLSTFKHLQSQIDSAIDQAATFIRLHSVDLAQQSLPEFIWTEKVSYTSPLVTEAYCLAALKVATSLVDNPGIVGESLDLGIPSRQRIDKYIWLFHQTPLFRSLPEWQLRASFIEGHLFLPIVNEHRLDVFPRKNMDPDDDYIRLIPFTWTATNNRNFTFASPAWLYDMIMVSVVDYQADEFMEAVAGLTFSEDLSMLVGLIQEVLTPYKTEPASPVTSLIDMSSVQCPRAKLSNIASGDIEEVRTCLRRFASFFLDHPAVRNAQRDDRATAWREVHNYLVAHVRHTQDNMRLNLQEQRRWYVSRNMPYFHWVRSNDDIACPITFGFVTCLVPYLVANPTVERAVIGNESESIVTSSDVSFDSVESKYYADDVCRHITNVTRIYNDCGSVVRDATEKNLNSVNFPEFAVTASGSEKQALRAMGEYERACCQAAFQRLEEASLQTATTEAERAKRRRRLDVWKVFLDTADPYGQIYVVRDFTARSVHVRETGIASTAKDVPLVSSSVPLVGGGPMLVT
Involved in the synthesis of labdane-related hydrocarbons by catalyzing the conversion of geranylgeranyl diphosphate (GGDP) to phyllocladan-16-alpha-ol in a two step via type B cyclization into a (+)-copalyl diphosphate ((+)-CDP) intermediate.
B2DBF0
Q1WSX7
LGT_LIGS1
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Ligilactobacillus
MNFLGVINPVALQLGPFQIRWYGIIIASAVILAVYLSVLEGRKQNILDDDIYDLLLYSLPVAIICARIYYVVFEWSYYSHHLSETYRIWDGGIAIYGALIGAVIVILIFCRRRNIPTWTLLDVIAPTVILAQGIGRWGNFMNQEAHGVATTLGFLKSLHLPKFIINQMYIDGTYYQPTFLYESLWDISGFVVLIILRRQKKLLKSGEVVLSYIIWYSFGRFFIEGMRTDSLMLGSLRVSQWLSLILFISAIAAIFYRRYNDPLLKWYTE
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Q1WSX7
P26270
PSMD7_DROME
Protein Mov34
Sophophora
MPSQEVSVNKVIVHPLVLLSVVDHFNRMGKIGNQKRVVGVLLGCWRSKGVLDVSNSFAVPFDEDDKDKSVWFLDHDYLENMYGMFKKVNARERVVGWYHTGPKLHQNDIAINELVRRYCPNSVLVIIDAKPKDLGLPTEAYISVEEVHDDGSPTSKTFEHVPSEIGAEEAEEVGVEHLLRDIKDTTVGSLSQKITNQLMGLKGLNAQLRDIKQYLQRVGDSKMPINHQIVYQLQDIFNLLPDITNDQFTGTMYVKTNDQMLVVYLASMVRSIIALHNLINNKLANRDAEEGKSDSKEAKEKNKDSKDKDNKETKDKDGKKAEEKADKGKDEGGKGSRK
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
P26270
A9A3N5
MTAP_NITMS
5'-methylthioadenosine phosphorylase
Nitrosopumilus
MEKDVEIGIFGGTGIYDSGLLEDAKEVDIDTPYGKPSDTITVGTFKGRKIAFLPRHGKKHTIPPHMINFKANIWAFKELGVTRIIAPSAVGSLKEELAPGHFVLPTQFLDFTKSRDGSFSEDGRVIHISVADPFCPELQSSITEVTDSLDMNIHKDCTYVCIEGPRFSTKAESKFYRTTGADIIGMTLVPECQLAREAQICYASISTVTDYDVWAEKPVTAKEVLETLSKNVEGTKKILTELIEKIPKDRSCSCAKALEEAEF
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
A9A3N5
P53248
PEX8_YEAST
Peroxisomal protein PAS6
Saccharomyces
MFDHDVEYLITALSSETRIQYDQRLLDEIAANVVYYVPRVKSPDTLYRLVGALFRSQFIVQLPPLRLLHIVKDVFLWKLEVSEPTLPISKFYLVWNAVFESHRATWNLSQLMVLDGVLVTYPSFKQLNNAYFIDESSNKTALYYRNWKLQLFSPIWAQLWNTAIVRANLSIQHCLLIALALLFNQSNRSALLHGVDVSWNLVTEKLLDLLEEYVHGIVQPMEIFSTDSVLSTNLNHLASCLTSSITRSNEATLVNSVRKLERICRYLSDTVASLKEQQLDFKFQNVFILIILALKELSAMNMTILPNHKDTFYSMICLSLFHVHVLTQKIGTVGFPSYDYVYDNLVTYFIVMDDLSKITTVLELMKRNNTKQDPNKLVFYINFLNKITNYYGCRIRLPFITEFIEPLLHFDVFFSGKTGNTLDIEIKESIHTLTITVLSIDSSYSSQVAQWQVSRILVYLKMSMDQFIAGKLSANQILLIFGHLSTQLPSLHNYNKHLLRDSLHETYIRIVNVKNPEKKNVLIECLIVQIAFINNPHHLIGWLNICLQLINTHNKKLLQQLWEMVSSLESSLAIDWWYTTVLSSQSSKL
Required for peroxisome assembly.
P53248
Q86MI0
DVE1_CAEEL
Defective proventriculus homolog protein
Caenorhabditis
MFPMRVIVETVRSQHCLTCSNEGHMITDTYAIVAGTTTLNQLVETVLAALGHSSMSTSARGLIQVNNWKPLPFDQITENLDDTVENLFKDISSHVVLKILSKPSTDSNSVQCISEVKNKLLKAAVNKNPNVLTNVDNQQVKDVINTIIAGDETLLNSEQIGAVNEWLDTLETNEDRRSPTQVQRFNTLYEIPRLDKWFKSDANPSKQKMNNYLSQLNQSPFRKNNSKISYQQICNWFTQKRSSSRTLAPVDLVQVSSAQTAAQLLPGFQLNLLQSLFGEQRQKFDFYDKLDETKIVGGSDSPSPADDEIHSNSDETIQDTLFSINIKPEPEIDSIASSPDMANSMRESLSSTSPKLLSGLDLGAFSTHSSSTNSMQNANSSVFSAARSRLMFDPLTELPVLEKWFEENPHPTWMQIDQYTQCLNNCAYRENYPHISQHNVKIWFKNRRAKCKRLLNGMQEKLEQKVFV
Transcription factor . Acts during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR) . Required during mitochondrial stress for the activation of genes involved in the mtUPR, in concert with histone deacetylase hda-1 . In response to the citrate-induced mtUPR, positively regulates transcription of transcription factor nhr-80, thereby leading to modulation of lipid metabolism . May play a role in modulating the decline in protein homeostasis associated with normal aging . Required for embryonic development and maintenance of mitochondrial morphology .
Q86MI0
Q5JER9
NUCS_THEKO
Endonuclease NucS
Thermococcus
MSKDKVTVITSPSTEELVSLVNSALLEEAMLTIFARCKVHYDGRAKSELGSGDRVIIVKPDGSFLIHQSKKREPVNWQPPGSRVRLELRENPVLVSIRRKPRETLEVELEEVYMVSVFRAEDYEELALTGSEAEMAELIFENPEVIEPGFKPLFREKAIGTGIVDVLGRDSDGNIVVLELKRRRAELHAVRQLKSYVEILREEYGDKVRGILVAPSLTSGAKRLLEKEGLEFRKLEPPKRDSKKKGRQKTLF
Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.
Q5JER9
Q39X78
SPEA_GEOMG
Biosynthetic arginine decarboxylase
Geobacter
MERWSINDSAKIYNLPNWGADLFSINKKGNVCVHPSPTSKHSIDLRALVDDLIKRKIKPPILLRFMDVLQGRIAAINRAFKYAIDENDYPSTYQTFYPIKVNQQRQVVEAIAKFGKRYNIGIEVGSKPELVIGISFATGNGIPIICNGYKDKEYIETVLYATKIGYDITIVVEKMFELEKIIALSKKTGIKPKLGIRVKLSSKGTGKWATSGGEDAKFGLRMSEIIAAIGLLEQNELLDSVKLIHFHIGSQITKIDKIKSALIEGTRVYAEMRKLGVGIEYVDIGGGLGVDYDGSKSSYFSSVNYSIEEYANDVIYQIKNICEDAGVECPNIISESGRATAAHYSVLVTNLLNTNTQNLMPDFEETLNGAEKLAPTVKKLVDIYKSIDRYSLREDYHDTVQLIQEAVSLFSLGYLTLAERAMAEWLHGKILRKINGIVEKIKPIPEELQNFQLSLRQTYFANFSLFQSIPDSWAIDQLFPIVPIQRLNQKPDVMASIADITCDSDGEITSFVGENGRTKYLPLHKIRKDEDYFVGFFLIGAYQEILGDMHNLFGDTNAVHVTFNKKTGYKIDTVINGDATWESLKYVQYKGPEILKHVRDTMEKDVALRKVSIEESSHFLELLDRTLLGYTYLGE
Catalyzes the biosynthesis of agmatine from arginine.
Q39X78
A4XTZ4
TIG_PSEMY
PPIase
Pseudomonas
MQVSVESTSALERRMTVGVPVERIETEVNKRLQQTARRAKVPGFRPGKVPMSVIRQRYEDAARQEALGDLIQATFYEAVVEQKLNPAGAPAVEPKSFEKGKDLEYVATFEVFPEFEVTGFDSIAIERLQADVADSDVDNMLDILRKQNTRFEAVERAAENGDQLNIDFVGKIDGEAFAGGSAKGTQLVLGSGRMIPGFEDALVGVKAGEERVINPTFPEDYQNLDLAGKTAEFAVTVNSVSAPQLPELNDEFFALFGIKEGGLEGFRAEVRKNMERELRQAIKSKVKNQVMDGLLAANPVEVPKALIGNEVNRLRVQAVQQFGGNIKPDQLPAELFEEQAKRRVVLGLIVAEVVKQFDLKPDEARVRELIEEMASAYQEPEQVVAWYYKNDQQMNEVRSVVLEEQVVDTVLQKANVTDKAVSYEDAVKPAEAPKAD
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
A4XTZ4
B8CIB4
RAPA_SHEPW
ATP-dependent helicase HepA
Shewanella
MPFSLGQRWISDTESELGLGTVVGMEGRMVTVLFSATGENRLFSRSEAPLTRVIFNPGDKVESHDEWSLTVTEVEEKDNLIIYHGIHSETGEQASLRETLLNHNIRFNKPQDRLFAGQIDRMDRFGVRYQCQLLRNKLATSDLLGLQGPRVGLIPHQQWIAHEVGQRFAPRVLLADEVGLGKTIEAGLIIHQQLLTGRAERILVIVPDTLRHQWLVEMLRRFNLRFSVFDEDRCVEAYADNDNPFYTEQLVICSLELLRKKKRLEQALDADWDLMVVDEAHHLEWSEDAPSRAYKVVEALSEVVPGVLLLTATPDQLGHQSHFARLRLLDPDRFYDYPSFLKEEESYKDVATAADALACGESLSSEAIASLTQLLSEKDISDSINLIQDASANADKRNQAREELLQELLDRHGTGRVLYRNSRASVKGFPTRNLHIHPQPMPEQYVTASRVSAMMNKHLDTNAKVRQVLSPEKIYQDFDSGSASWWKFDPRVDWLIDFLKTNRSKKVLIIASQAETALSLEEALRTREGIQATVFHEGMSIIERDKAGAYFAQETGGAQALICSEIGSEGRNFQFASHLVLFDLPLNPDLLEQRIGRLDRIGQKNDVEIHLPYLAGTAQERLMQWYHQGLNAFECTCPSGHILFGEFSGELLETLTTDDESSLETLLDNTKSRYQELKVAMEQGRDKLLEINSHGGERANKLVESLAARDEDTQLIGSVIRLWDIIGVEQEDSGENAIVLHPSEHMMFPTYPGLPEDGITVTFDRDMALSRDDIALITQEHPIVQTGLDLITSSETGTTSVAVLKNKALPAGTVFLELIYMADASAPKSSQLYRYLPPTPIRILLDKSGNNLSDNVTYESFDRQLSAVNRHIASKLVTASQAILHPLFAKGETFAANELKLLTETAREKMTQQLTGELERLKALKAVNPNIRDEELTHLSEQMSELNRYLDSSQLQLDAIRLVLVSHA
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair.
B8CIB4
Q9XJY3
NU4LM_MACMR
NADH dehydrogenase subunit 4L
Macaca
MTPTYMNIMLAFTISLLGMLIYRSHLMASLLCLEGMMMSLFIMTTLIALNTRSPLINIMPIILLVFAACEAAVGLALLVSISNTYGLDYIHNLNLLQC
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
Q9XJY3
B8IN27
CLPX_METNO
ATP-dependent Clp protease ATP-binding subunit ClpX
Methylobacterium
MSKAGGNDSKSTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREESKSSLVKSRDGVPTPKEIRRVLDDYVIGQDFAKKVLSVAVHNHYKRLAHAAKHNDVELAKSNILLIGPTGSGKTLLAQTLARILDVPFTMADATTLTEAGYVGEDVENIILKLLQASDYNVERAQRGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVDTTNILFICGGAFAGLERIISARGKGTSIGFGATVQAPDDRRTGEIFRNVEPEDLLKFGLIPEFVGRLPVLATLEDLDEIALKRILQEPKNALVKQYQRLFEMENVDLTFQEEALTLVARKAIERKTGARGLRSILESILLETMYDLPGLDSVEQVVIGPEVVDGKARPLYIHGDRSKDAPASVSA
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
B8IN27
Q65H34
AROE_BACLD
Shikimate dehydrogenase (NADP(+))
Bacillus
MKPIYGLIGNPVAHSMSPDIHNAALKDLSLEGHYHAFRVENEDLEDAVKGMRALGIQGFNVTVPHKVSIMKHLDRIDESAEALGAVNTVRREKEGLVGYNTDGAGFLKSLKPSLDRPLSELSILLIGAGGAARAIFTTLAAETPKRLDVANRTPEKALAFTQRFDGEARALSLQEAEADLSAYDIVIQTTSVGMHPNVEAAPLSLANAKETCLVCDIIYNPLKTALLHEAEAKGLKTLDGVGMFIGQAALAFELWTGHEPNMEKMKSIVLQQLGGKSC
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Q65H34
C0HKQ5
XAC1_XYLAI
Xylopin
Alloxylocopa
GFVALLKKLPLILKHLH
Antimicrobial and mast cell degranulating peptide which probably acts by forming pores in membranes . Active against both Gram-negative and Gram-positive bacterial strains as well as against yeasts . Has leishmanicidal activity (IC(50)=25uM). Has little hemolytic activity .
C0HKQ5
P0CW11
GRPE_METMA
HSP-70 cofactor
Methanosarcina
MKKSRKKENMDSKERNQKEAERSEARNSESPAEKAGETKVSPENEPSSPEAEKNPEEACREENEILKDQLFRLAADFDNFRKRTARQMEENRKSVLEQVLLDFVEVTDNFDRAIKSARTAEDMGPIVSGIEQLSKQFFSILEKYGLERVKCEKAGEFDPHRHEAIHHIETSEVPDNTIVEIYKEGYALNEKVVRPALVSVARSPEEAEK
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
P0CW11
Q7NRV7
RL19_CHRVO
50S ribosomal protein L19
Chromobacterium
MDLIQKLEQEEIARLGKTLPEFAPGDTVVVQVKVKEGNRERLQAYEGVVIAKRNRGLNSAFTVRKMSAGEGVERTFQTYSPLVASVEVKRRGDVRRAKLYYLRGRTGKSARIKEKLPARKQG
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Q7NRV7
Q3A4X0
PPNP_SYNC1
Xanthosine phosphorylase
Syntrophotalea
MSEFKNVTLIKKANVYYDGKVTSRTVIFADGTKKTLGIMMPGEYTFDTAAAEVMEMLGGSMEVLLPGAETWQSFHEGQSFEVPANSQFSLKIKEVADYCCSYLK
Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.
Q3A4X0
Q6Q5K6
HUG1_YEAST
null
Saccharomyces
MTMDQGLNPKQFFLDDVVLQDTLCSMSNRVNKSVKTGYLFPKDHVPSANIIAVERRGGLSDIGKNTSN
Involved in the MEC1-mediated checkpoint response to DNA damage and replication arrest.
Q6Q5K6
A4WR15
SYY_CERS5
Tyrosyl-tRNA synthetase
Cereibacter
MTYHPKSDFLRVMQERGYLADCTDMQALDEAMSKGVVPAYIGYDATAASLHVGHLLNIMMLRWLQKTGHKPITLMGGGTTKVGDPSFRSEERPLLTPEKIDANIAGMKQVFARYLDYSDGATGALMLNNAEWLDSLNYLDFLRDIGRHFSVNRMLSFESVKSRLDREQSLSFLEFNYMILQAYDFLELFRRYGCRLQMGGSDQWGNIVNGIDLTRRVLEGEIFGLTSPLLTTSDGRKMGKSAGGAVWLSGEMLAPYDFWQFWRNTTDADVGRFLKLYTELPVEECDRLGALQGAEINGAKIRLANEVTTLLHGREAAEAAEATARAVFEQGGVGGALEVVEIAPATLGEGLSVTHFLVAAGLVTSGKEAKRLVAENGLRFNNEPVSDANAPVTAAMIGDELKVSIGRKKHKLVRLA
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
A4WR15
Q5E3S1
CHEB_ALIF1
Protein-glutamate methylesterase/protein-glutamine glutaminase
Aliivibrio
MAIKVLVVDDSSFFRRRVSEIINSDPRLEVIDVAVNGKEAVEKAKSLKPDVITMDIEMPVMDGISAVREIMKACPTPTLMFSSLTHDGAKATLDALDAGALDFLPKKFEDIARNRDEAVSLLQKRIAEIARKKSFMRRPVLSSQSTSTVESRTATTRTATSALTASPVKAAPAAPIAQRFKATGKKYQLTAIGTSTGGPVALQKILTAIPANYPHPIILVQHMPATFTAAFAARLNNLCKIQVKEAEDGDVLKPGCAYLAPGGLQMMVDGRPGASRLKILDGGERMNYKPCVDVTFGSAAKVYGDKVLSMILTGMGADGREGCRMLKAGGATIWSQDEQSCVVYGMPQAVDKAGLSSESLPLDRIAERMLVEVGLK
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Q5E3S1
C0ZF55
RIMP_BREBN
Ribosome maturation factor RimP
Brevibacillus
MSKVTGIVTELITPIVEEVGLELVDIEYKKEGSNWFLRVFIDNETGNIDIDDCRLVSEKLSEKLDEVDPIPTAYFLEVSSPGAERPLRKDKDFTKAVGRNVHITTKEPIEGATTFEGELVSYEDGKLTVKEAKKTYVISQEQIDTARMAIIF
Required for maturation of 30S ribosomal subunits.
C0ZF55
Q4WWR2
SLU7_ASPFU
Pre-mRNA-splicing factor slu7
Aspergillus subgen. Fumigati
MSRKPADVASKERNEYIPSFIAKKPFYIDDESTANDYLEHQRLQKQATDQSKWYDRGKRAGPAATKYRKGACENCGAMTHKSKECLSRPRKLGAKWTGKDIQADEVVQNVELGWDAKRDRWNGYDPSEYRQVIEEYEELEKLKRNTKPGAQDGKKIMDGELDDEEAAIEEARYAEESDMGRQQSTATRNLRIREDTAKYLLNLDLDSAKYDPKTRRMVDMGAQDDQAAALVAEENFVRASGDAAEFERAQRYAWESQERGDKKIHLQANPTSGEILRKKEQAETEAKRQAQRKALLEKYGGEEYLKPTPLRETMVIENERFVEYDESGAIKGAPKNAVKSKYPEDVLVNNHTTVFGSWWHNFQWGYACCFSTVKNSYCTGEDGKKAFEEAEMRSMGLLPGPETSDQTSPPAKGETNDIHEAEDLSDRSQRKADTETNTRKRTMMEMKSGVSEEELESYKRSRLAADDPMASFIGKE
Involved in pre-mRNA splicing.
Q4WWR2
A2SQG6
RIBB_METLZ
3,4-dihydroxy-2-butanone 4-phosphate synthase
Methanocorpusculum
MFTFNTIEEALKSLQNGEMIIVTDDENRENEGDLICAAEYATTENVNFMAKYGRGLICMPMGRSLVEKLCLPPMVLKNTDNHETAFTVSIDHVDTTTGISAVERGITARKCIDPNARPEDFRRPGHMFPLQAKDNGVFEREGHTEATVDLMKLAGLREAGLCCEIMADNGEMMRTPELISMAKQYNLTFVTIKDLQAYRRKQEASALAVEQKNMSPMDC
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.
A2SQG6
Q1IYF7
RS20_DEIGD
30S ribosomal protein S20
Deinococcus
MALRHKSAQKRHRQSLKRRLINRSRKNTIKTFSKKAVVAAQNGAENAVELHRKAESLIDKAAKGSTLHKNAAARKKSRLAKALNKAKAAQAAQPA
Binds directly to 16S ribosomal RNA.
Q1IYF7
B7LNW4
FABA_ESCF3
Trans-2-decenoyl-[acyl-carrier-protein] isomerase
Escherichia
MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNYDKGYVEAELDINPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLPTAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSSF
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
B7LNW4
Q7Z392
TPC11_HUMAN
Trafficking protein particle complex subunit 11
Homo
MSPTQWDFPVELCCRPMAFVTLTGLDVVYNAVHRAVWDAFCANRRADRVPISFKVLPGDHEYPKCRPKRTSYEWYIPKGILKTGWMNKHLNLVPALVVVFYELDWDEPQWKEKQSECATRVEIVRQSLQGRNTKVAVVLIQKKTPLPPGEDVIASERAAALCNACELSGKSLFVLPHTDHLVGYIIRLENAFYEHAQTYYYTEIRRVKSHKEFLNKTTHQLLFVRHQFKIAFFSELKQDTQNALKNYRTAYNLVHELRAHETNILEIKTMAGFINYKICRLCFQHNTPLDAIAQFRKHIDLCKKKIGSAELSFEHDAWMSKQFQAFGDLFDEAIKLGLTAIQTQNPGFYYQQAAYYAQERKQLAKTLCNHEASVMYPNPDPLETQTGVLDFYGQRSWRQGILSFDLSDPEKEKVGILAIQLKERNVVHSEIIITLLSNAVAQFKKYKCPRMKSHLMVQMGEEYYYAKDYTKALKLLDYVMCDYRSEGWWTLLTSVLTTALKCSYLMAQLKDYITYSLELLGRASTLKDDQKSRIEKNLINVLMNESPDPEPDCDILAVKTAQKLWADRISLAGSNIFTIGVQDFVPFVQCKAKFHAPSFHVDVPVQFDIYLKADCPHPIRFSKLCVSFNNQEYNQFCVIEEASKANEVLENLTQGKMCLVPGKTRKLLFKFVAKTEDVGKKIEITSVDLALGNETGRCVVLNWQGGGGDAASSQEALQAARSFKRRPKLPDNEVHWDSIIIQASTMIISRVPNISVHLLHEPPALTNEMYCLVVTVQSHEKTQIRDVKLTAGLKPGQDANLTQKTHVTLHGTELCDESYPALLTDIPVGDLHPGEQLEKMLYVRCGTVGSRMFLVYVSYLINTTVEEKEIVCKCHKDETVTIETVFPFDVAVKFVSTKFEHLERVYADIPFLLMTDLLSASPWALTIVSSELQLAPSMTTVDQLESQVDNVILQTGESASECFCLQCPSLGNIEGGVATGHYIISWKRTSAMENIPIITTVITLPHVIVENIPLHVNADLPSFGRVRESLPVKYHLQNKTDLVQDVEISVEPSDAFMFSGLKQIRLRILPGTEQEMLYNFYPLMAGYQQLPSLNINLLRFPNFTNQLLRRFIPTSIFVKPQGRLMDDTSIAAA
Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
Q7Z392
Q5R7D1
DDX42_PONAB
DEAD box protein 42
Pongo
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFYKIGSKRANFDEENAYFEDEEEDSSNVDLPYIPAENSPTRQQFHSKPIDSDSDDDPLEAFMAEVEDQAARDMKRLEEKDKERKNVKGIRDDIEEEDDQETYFRYMAENPTAGVVQEEEEDNLEYDSDGNPIAPTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQKELEPGDGPIAVIVCPTRELCQQIHAEGKRFGKAYNLRSVAVYGGGSMWEQAKALQEGAEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPITSATKGIPGFGNIGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRKEACNRESKMEPKMEPKMEPKVDSNKMDKVDSKTDKTADGFAVPEPPKRKKSRWDS
ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
Q5R7D1
C9J798
RAS4B_HUMAN
Ras GTPase-activating protein 4B
Homo
MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVHQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway.
C9J798
Q8XLG5
ACCA_CLOPE
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Clostridium
MSRELIRTADAWNKVKIARDPNRPNAKFYINEIFDEFIELHGDRNFGDDKAIIGGIALLNNLSFTVVGICKGENTKENIKRNFGMPHPEGYRKALRLMKQAEKFKRPVICFVDTPGAFCGIGAEERGQGQAIAQNLVELMGLKVPLISIVIGEGGSGGALALAVADKVFMLEHSIYSVLSPEGFASILWKDSSRAEEAASVMKITAQDLKSFNIIDKIIKEPRGGAHKNPIKMAQNIKKTILEALGEMKGTDLDTLLNERYNKYRNIENNL
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
Q8XLG5
Q83QL0
EX7L_SHIFL
Exodeoxyribonuclease VII large subunit
Shigella
MLPSQSPAIFTVSRLNQTVRLLLEHEMGQVWISGEISNFTQPASGHWYFTLKDDTAQVRCAMFRNSNRRVTFRPQHGQQVLVRANITLYEPRGDYQIIVESMQPAGEGLLQQKYEQLKAKLQAECLFDQQYKKPLPSPAHCVGVITSKTGAALHDILHVLKRRDPSLPVIIYPTSVQGDDAPGQIVRAIELANQRNECDVLIVGRGGGSLEDLWSFNDERVARAIFASRIPVVSAVGHETDVTIADFVADLRAPTPSAAAEVVSRNQQELLRQVQSARQRLEMAMDYYLANRTRRFTQIHHRLQQQHPQLRLARQQTMLERLQKRMSFALENQLKRAGQQQQRLTQRLNQQNPQPKIHRTQTRIQQLEYRLAEILRAQLSATRERFGNAVTHLEAVSPLSTLARGYSVTTATDGNVLKKVKQVKTGEMLTTRLEDGWIESEVKNIQPVKKSRKKVH
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Q83QL0
O13353
CHS4_MAGO7
Class-IV chitin synthase 4
Pyricularia
MSLPERPGAKASYEQRNSYRKSPSRRNRPNDIEASGYYPVTGGQHQRGPSVNSFAETIRSPNSNIESAPLSPSAEQIEHGSDQPFQRKRSLIRPERNRIDRDHPNYHYRKHAAKMNTLPSSTGNDPVLEDVSGATESGPPSGSNSASGSGVREENIPRKSRKASGRETVAEKSDNTRRRVSTRNSKIVKEGKRKEKIPEQLRPPSAWNVYCAVITFWSPDFIMKCCGMPAKAQRRAWREKIGLISLILIIMGVVGFLTFGFNQAVCGGPVLRLHINSVDRSYMIFHGTAYNLDGSHHPVAEGIPKRLDGTGANVVYDLPEGYGGTDGSFMFQNVNGKCKGLITKAPNSDVPSEGDNLAWYFPCHARNQDGSSQPNMTYPYYFGYACHTTPLARSTFYTQLDKSADVYFTWADIRNNSRNLFVYSGNVLDLDLLFWFNRDQVNIPRRFEELRDKNNAANRAIRGRDATRTFMASGDRQIAECFEDIIKVGTVDTDTVGCIAAKVVLYVSLALILSVVGARFTLALIFQWFISKNYAADKTSQTSDKRKRNKQIEDWSEDIYRAPPRMPGDVGSSVAGASSSDHTSKRSSFLPTTSRFSTVYGAERSARNKSMPTTMASQASGGYMGPSSTAYRETNESRTSFLKSDPYATNTAPIEGPGPSGFIHDSVVPQPPSDWMPFGFPLAHTICLVTAYSEGELGLRTTLDSVAMTDYPNSHKVILVICDGIIKGKGESKSTPEYVLDMMKDHTIPVEDVEAFSYVAVASGSKRHNMAKIYAGFYDYGTQSNIPLDKQQRVPMMVVVKCGTPDEMVKSKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWKVTGISPDFYEIVLMVDADTKVFPDSLTHMISAMVKDPEIMGLCGETKIANKRDSWVSAIQVFEYFISHHLAKSFESVFGGVTCLPGCFCMYRIKAPKGAQNYWVPILANPDVVEHYSENVVDTLHKKNLLLLGEDRYLTTLMLRTFPKRKQVFVPQAVCKTTVPDSFMVLLSQRRRWINSTIHNLMELVLVRDLCGTFCFSMQFVIFIELIGTLVLPAAIAFTFYVVIISIINQPPQIIPLVLLGLILGLPAILIIITAHSWSYVLWMLIYLLSLPVWNFVLPAYAFWKFDDFSWGDTRKTAGEKTKKAGIEYEGEFDSSKITMKRWAEFERDRRARQSQYWGSRENVTGGVRTASGVWASAPPHHHQQQYDEYYSDA
Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.
O13353
P42471
EFTU_BRELN
Elongation factor Tu
Brevibacterium
MAKASFERTKPHVNIGTIGHVDHGKTTLTAAITKVLADQYPDLNEARAFDQVDNAPEEKERGITINVSHVEYQTEKRHYAHVDAPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYIVVALNKSDMVDDEELLELVEFEVRDLLSSQDFDGDNAPVIPVSALKALEGDEKWVKSVQDLMAAVDDNVPEPERDVDKPFLMPVEDVFTITGRGTVVTGRVERGVLLPNDEIEIVGIKEKSSKTTVTAIEMFRKTLPDARAGENVGLLLRGTKREDVERGQVIVKPGSITPHTKFEAQVYILSKDEGGRHNPFYSNYRPQFYFRTTDVTGVITLPEGTEMVMPGDNTDMSVELIQPIAMEDRLRFAIREGGRTVGAGRVTKITA
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
P42471
A4QCI7
TYSY_CORGB
Thymidylate synthase
Corynebacterium
MTVPTPYEDLLRKIAEEGSHKDDRTGTGTTSLFGQQIRFDLNEGFPLLTTKKVHFHSVVGELLWFLQGDSNVKWLQDNNIRIWNEWADEDGELGPVYGVQWRSWPTPDGRHIDQISGALETLRNNPDSRRNIVSAWNVSELENMALPPCHLLFQLYVADGKLSCQLYQRSADMFLGVPFNIASYALLTHMFAQQAGLEVGEFIWTGGDCHIYDNHKEQVAEQLSREARPYPTLELNKAASMFEYSFDDITVSGYDPHPLIRGKVAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
A4QCI7
Q7Z614
SNX20_HUMAN
Selectin ligand-interactor cytoplasmic 1
Homo
MASPEHPGSPGCMGPITQCTARTQQEAPATGPDLPHPGPDGHLDTHSGLSSNSSMTTRELQQYWQNQKCRWKHVKLLFEIASARIEERKVSKFVVYQIIVIQTGSFDNNKAVLERRYSDFAKLQKALLKTFREEIEDVEFPRKHLTGNFAEEMICERRRALQEYLGLLYAIRCVRRSREFLDFLTRPELREAFGCLRAGQYPRALELLLRVLPLQEKLTAHCPAAAVPALCAVLLCHRDLDRPAEAFAAGERALQRLQAREGHRYYAPLLDAMVRLAYALGKDFVTLQERLEESQLRRPTPRGITLKELTVREYLH
May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, or on SELPLG-mediated cell-cell adhesion.
Q7Z614
Q5B0C8
APTC_EMENI
Asperthecin synthesis protein C
Aspergillus subgen. Nidulantes
MTLPVLIIGAGLSGLTTARLLTNAHIPCIVFEASPPSRTQGYAISLRDWGFNALLRALGNLPLSSLTRAVAPDRHIGGWGWLDQSWRNNQTGEIIMMPPKESKEKPTILRANRNALRQWIADAGVGEDEEIDVRYGHRLVGVQLLREGGDGNVVTAEFANGATYTGSLLIAADGVHSTVRTLILPAVKPEILPVLVYHGDFKLSREEYECVIRPHAGESTIVAGVGDGFNTPLTVCDVTSTTVHMDWTYSRPSIGDNDPLYNPNITSEEAKVIPEALIEEINAKKLGEPWSLFLNGEAMRRHRVFNWLTRCVSMERSDVNSCTGKGVVFVGDSWHAMPIFGGEGGNHAIFDGIELAKMLEVAWGRSKEDVQAAIGKYYDKSWRRCNDAVRRSKQRFYQLHRPISEWIEIAEKQKMRA
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of asperthecin, an anthraquinone pigment . Polyketide synthase (PKS) aptA catalyzes the formation of the aromatic polyketide from acetyl coenzyme A and seven malonyl coenzyme A molecules . Polyketide is subsequently hydrolyzed by the action of the hydrolase aptB into endocrocin-9-anthrone . Endocrocin-9-anthrone is then oxidized into endocrocin by the monooxygenase aptC . Endocrocin is likely to decarboxylate spontaneously to form emodin which explains why there is no decarboxylase in the asperthecin biosynthesis cluster . Finally, aptC or another endogenous oxygenase catalyzes additional oxidation steps to form asperthecin .
Q5B0C8
Q8EG24
LPXH_SHEON
UDP-2,3-diacylglucosamine diphosphatase
Shewanella
MRTLFIGDLHLSADRLDITQAFNRFLDTELDDADALYILGDLFEVWVGDDLAAPFALELAHKLKQVSQTLPIFFIHGNRDFMLGKRFAEAAGMQLLPEVTCIELYGVKTVILHGDSLCTLDKAYQRFRKLRSFACARWLYSCLPKKRRQAIANKIRSNSQSSNQQKSYVIMDVEPSAVNALFVKTHTTRMIHGHTHRPAIHIVDNACQRIVVGDWYEQGSVLSVSANGVDLKSLPFETT
Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Q8EG24
Q5A201
GZF3_CANAL
Transcriptional regulator GZF3
Candida
MSMSDIQQRPQIPTTTTAAVAAAASTNVNTGAATTSTATTGNTPTTTPTSPIENISKVPVKPSVDVPVKPKLEQQQQQQSEQSSKPPPPPPEQQQQHQLPTPPIKPPKTGTTSSSSSTTTSSATSSKISMSGPVCGNCQTQTTPLWRRDETGQVLCNACGLFLKLHGRPRPISLKTDTIKSRNRVKQNGSNSQSSKSSGANTPELKSKEGKSGKKSPKSKKKSLGNGNGNGNSSHDHNTLTPLLPATSNNTPTFKSTTSQSQHQQNQNHHHQHHNHHHHLPNHVLQTHQVPLHYPSSTPTQFAPGLQRITSPLLLSTTSSSSSIRTEPNNNNTSKLTPIQAAAGALENMSNELGPSATFKKGNNINGISLMNKTKKDVSSINGSSTSLSSSSASSSIFSSVAPSTSSSSSLSNGTTINNPAPKLPTLGSKISSPSSQPFTRSTTPLQTLPPLHKIASHESSLPPLHNISTYNNNNSGGGADGGQQSMANYSQTNRSPINGNQDNNNNNNNNNNNNNNGNNNGNNNSNNNGNNFTASAHEVTLLKTRISELELVNDLYRTRIMELEAMEQAARLRENSMKKRLDEVMNLQINYQNLLNNNGGMSSQTQPQPSQQPQQAGQYYSNNNNNNNNDQGSQSISPNVSITGSTTITSPNSRSKIISETTPTHHQQQQGGVGAGDNESIILPPLKRNRTDELTDANGNGNGNDNKKVKI
Probable transcription factor involved in response to fluconazole, LiCl, and copper.
Q5A201
Q5XC23
Y905_STRP6
UPF0122 protein M6_Spy0905
Streptococcus
MNTMEIEKTNRMNALFEFYAALLTDKQMNYIELYYADDYSLAEIADEFGVSRQAVYDNIKRTEKILETYEMKLHMYSDYVVRSEIFDDMIAHYPHDEYLQEKISILTSIDNRE
Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein.
Q5XC23
B2GD42
RNC_LIMF3
Ribonuclease III
Limosilactobacillus
MITQLQDYLAKTYGIHFNNPALLAEAFTQASYVNEHPHENLKYYERIEFLGDAVLQLFVSEYIYRRYPELPQGKLTRLRAAMVCEDSFSKFAKECHFDQYIRLGKGEEMAGARNRASLLCDIFESFIGALYLDQGRQAVEQFIQTVIFPKLDLGWFDHAVDAKTSLQEFLQRNGDVAIEYDLLSEGGTENDPVFEVEVTVDGKKVATGQGSSKKHAEMEAAKHALEKLRMDK
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
B2GD42
Q73SK9
Y4064_MYCPA
Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_4064c
Mycobacterium avium complex (MAC)
MTVPNDDTWGPATSVGTTATMAAAARAIATRDGVINDPFAEPLVRAVGVNFLTRWAIGELVASDVDVEGSPWGLAQMPASIAARTRYFDEFYADAAAAGIRQAVILASGLDTRAYRLDWPAGMTVFEIDQPAVIEFKTTALARLGAEPKADLRTVAVDLRDDWSTALATAGLDSSKPTAWIAEGLFGYLAPEAQDGLLDAVTALSTPGSRLGSEAVPNTADMDPHAARERMRAATAKWRDHGFELDVDVISFAGERHDVGAYLQAHGWTTVATPMAELLADHGLPAIARADDDRQTMNGVTYYTSTLGTGRQR
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Q73SK9
Q9PQE6
SCPA_UREPA
Segregation and condensation protein A
Ureaplasma
MNRMSEKQIQNSLFEYKFIDFNGPLDTLCVLIKQKRLDINNLDILELSKQYVNFVNQLIKTIDIDILGDHLAMASYLLELKTRMLMPTVDEKQIMSIEEDRQNLIDRLIEYNGYKNLSEHLKQRFEFRATMMDLPQQDYEQFYLKDAIYKPLPNHLDSMILKNIMDKIIYENELKNYKINKIKVHEYDVKQLEQLLLNYLKQSPNQQASMLSFFDIQAVIDKNKRFFAIMFLIILILINRNEILFEELDNDYLLKINIERVVDDYNSSSVEQAKNLTSNLTKDTIINFKGEDNE
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
Q9PQE6
Q03NS1
THIE_LEVBA
Thiamine-phosphate pyrophosphorylase
Levilactobacillus
MSVTFEPGLLRAYFVAGSQDVPGQDLRDVLAKMLAAGITAFQFRDKATSTLTPEQRLALGRDLRAQCRVANVPFIVDDDVELALALDADGIHVGQSDQRVQQVIQAVAGRNIFVGLSCSTMAEVTAANAIAGIDYIGSGPIFPTISKADADPVVGTAGLQKLVAQSRVPVVAIGGVTVDSLPAIAETGAAGVAVITLLTHSHDVDADTAAMRQAFSK
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
Q03NS1
O74935
ACOX2_YARLI
Acyl-coenzyme A oxidase 2
Yarrowia
MNPNNTGTIEINGKEYNTFTEPPVAMAQERAKTSFPVREMTYFLDGGEKNTLKNEQIMEEIERDPLFNNDNYYDLNKEQIRELTMERVAKLSLFVRDQPEDDIKKRFALIGIADMGTYTRLGVHYGLFFGAVRGTGTAEQFGHWISKGAGDLRKFYGCFSMTELGHGSNLAGLETTAIYDEETDEFIINTPHIAATKWWIGGAAHTATHTVVFARLIVKGKDYGVKTFVVQLRNINDHSLKVGISIGDIGKKMGRDGIDNGWIQFTNVRIPRQNLLMKYTKVDREGNVTQPPLAQLTYGSLITGRVSMASDSHQVGKRFITIALRYACIRRQFSTTPGQPETKIIDYPYHQRRLLPLLAYVYALKMTADEVGALFSRTMLKMDDLKPDDKAGLNEVVSDVKELFSVSAGLKAFSTWACADVIDKTRQACGGHGYSGYNGFGQAYADWVVQCTWEGDNNILTLSAGRALIQSAVALRKGEPVGNAVSYLKRYKDLANAKLNGRSLTDPKVLVEAWEVAAGNIINRATDQYEKLIGEGLNADQAFEVLSQQRFQAAKVHTRRHLIAAFFSRIDTEAGEAIKQPLLNLALLFALWSIEEDSGLFLREGFLEPKDIDTVTELVNKYCTTVREEVIGYTDAFNLSDYFINAPIGCYDGDAYRHYFQKVNEQNPARDPRPPYYASTLKPFLFREEEDDDICELDEE
Oxidizes strain chain acyl-CoAs with a chain length of 10 to 14 carbons. Also active toward the 2S isomers of acyl-CoA-esters containing a 2-methyl group.
O74935
P28363
RPA1_EUPOC
DNA-directed RNA polymerase I largest subunit
Euplotes
MATIFDSLISSRLDGTRFSFYNDEEIQQMSVKEIHNPMAYDELNNPTSHGICDESMGVSALDKLSKCKTCGCDSVYCPGHMGHIKLTSTCYNPFTMKLLHSLLKSKCLVCHRLRISPKRIELFEIRLKLIKLGYLVEAEKLSDFNHFSLESIDSAIRILRKKTKGKTNKKEEKEDSEEVEEDKYAAKEALENLIQKEKENREIFYSHISSILQEDTPNESIGNAITVAIRDITKEIMNSVVPSKCPHCDVCNPRIKKDGATKFFQMPLSNRDTKAMLSSHGRIDMRIDISTMGAISEYDEEDDESSGESEVREGDEEQEKKQKYLSPIEVLEHMRRLWDVEDTLLNELFDNYKIFFMNNLLVSQNRFRPESSGGKQSGDDRDYLHAHSAMLTKIINANIAFRRTIELKENLTDDRNLETESEKSKTQQIDLSKTEITSKQVIKAWAELQESVNCYLDSSLAAKLENKEKPGLRQLLERKEGIFRMKMMGKRVNFAGRSVISPDPYISTDQIGVPEFIARTITFPEPAKNIEKLKRCVINGAHKHPGANFIEYPNGERKALENMTLEEKKQSSIIRKWRKIVYRHMQTGDPLLVNRQPTLHKPSIMAHNAIILPKEQTIRMHYSNCKSYNADFDGDEMK
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. RNA polymerase I is essentially used to transcribe ribosomal DNA units.
P28363
A4YKQ8
ISPG_BRASO
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
unclassified Bradyrhizobium
MNKPETVTENSLASDVAGPAPRHQTTKVMVGNVAVGGGAPIVVQSMTNTDTADVDSTVAQVAALARAGSEMVRITVDRDEAAAAVPHIREQLDKRGITTPLIGDFHYIGHKLLTEYPACAEALAKYRINPGNVGFKDKRDTQFSTIIELANKYGKPVRIGANWGSLDQELLSKLMDENAASANPRNARAVMREAMVQSALHSAERAQELGMPKDRIILSAKVSAVQDLIAVYQDLAARSDYAIHLGLTEAGMGSKGIVASSAALGILLQQGIGDTIRISLTPEPGGDRTLEVQVAQELLQTMGFRTFVPLVAACPGCGRTTSTTFQELARSIQDFIRDEMPTWKIKYPGVEALNVAVMGCIVNGPGESKHANIGISLPGTGEAPAAPVFVDGKKFRTLRGPTIAADFKALVIDYIDQRYGSGAKAPESVTAAE
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
A4YKQ8
Q9C9R6
PUM7_ARATH
Putative pumilio homolog 7, chloroplastic
Arabidopsis
MDEFREASSVSSSPSTPLRTPLHSPNLFNGDFSVSNRFSFKSSSDYSLSSSFSNGLCSPEDSSSPFSSPPFNGIIPKHNHTSSSPVSFDSLFFKDHEKSHVNGTDDLGLCEDLYRMNIKEDVEEDQIRYARTETLKDPLPKSDHTDFTPDPLYNFSPKHYEPSNGGFVSGGFPYGFFRPPKESSINQSCASWSGFDQSKNDDKRNMFGNNPQQFGWPSYSSSNSGTSPYNNGQEIFENRGGMREYSAYSPPHQPEVSYKHQNYRTTTSDILPLFCQRTQVPMVSKCSEPFSSDESFFMNGKSIDHQRSNTRALMSNNGNPTEICHPSLPNMCDIQGYVYLMAKDQHGCRFLQRIFDEGTSVDAMIIFNEVIAHVVELMMDPFGNYLMQKLLDVCTEEQRTQIVLVATEEPGQLIRISLNAYGTRVVQRLVETIRSGKQISLVKLALRPGFLDLIKDLNGNHVIQRCLQCLSTEDNKFIFDAATKFCTEIATHRHGCCVLQKCIAYSMRQQREKLIAEISRNSLLLAQDPFGNYAVQFVIELRIPSAVAMMLAQLKGHYVQLSMQKFSSHMVERCLMHCPESRPQIVRELVSVPHFDQLLQDPYANFVIQAALAATKGPLHASLVEVIRPHSILRNNPYCKRIFSRNLLKK
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of target mRNAs.
Q9C9R6
B7V665
RS13_PSEA8
30S ribosomal protein S13
Pseudomonas
MARIAGVNIPDNKHTVISLTYIYGVGRTTAQSICAATGVNPAAKIKDLSDEQIDQLRNEVAKITTEGDLRREINMNIKRLMDLGCYRGLRHRRGLPVRGQRTKTNARTRKGPRKPIRK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
B7V665
Q13E56
RNPH_RHOPS
tRNA nucleotidyltransferase
Rhodopseudomonas
MRPSRRAPDELRAVSLERGVVKYAEGSCLVKFGDTHVLVTATLEERLPPWLKGQGRGWVTAEYGMLPRATLERTRREAAAGKQNGRTVEIQRLIGRSLRAIVDLQALGERQITVDCDVLQADGGTRTASITGAWVALADCLGWMKTRNMIKGTVLRDNVAAISCGIYNGTPVLDLDYAEDSEAETDANFVMTGDGRIIEVQGTAEKTPFSQDEFLALMALAQKGVTRLVDLQKMAVA
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
Q13E56
Q2GJV4
RS15_ANAPZ
30S ribosomal protein S15
phagocytophilum group
MSITPSKKSELISEYRIKEGDTGSAYVQCAILSERIRNLTEHLRIHKKDYHCRRGLMVLVCKRRKRLQYIKNKYGSDLYLDLVKKLGIRDVFH
Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.
Q2GJV4
A5E8V7
PNCB_BRASB
Nicotinate phosphoribosyltransferase
unclassified Bradyrhizobium
MTVTDIASRTYNHGWRLDPIVRSLLDTDFYKLLMLQMIREFYPDQKVTFSVINRTKRVRLGDVIDEGELRAQLDHARTIRFTKKELIWLAGNTFYGKTHMFSPDFLAWLAHFRLPDYELHKADGQYELHFHGPWTHTTMWEIPALAIVNELRSRQAMKGQGRFALDVLFARAKAKLWAKVERLRRLEGLRLSDFGTRRRHGFLWQRWCVEAVKEGLGPSFTGTSNVLLAMDNDLEAIGTNAHELPMVAAALARDDDELRFAPYRILDQWRQTYAGNLLIALPDAFGTKAFLRDAPDWVADWTGFRPDSAPPIEAGEEIIAWWKSKGRDPKQKLLVFSDAMDVESIEQIHHRFSDRVRLSFGWGTNLTNDFVGCAPDGSVDLDPISLVCKVTSVDGQPAVKLSDNPEKATGDPAEIARYLRVFGDAGRVRTPVVV
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
A5E8V7
A5VZ39
Y988_PSEP1
Nucleotide-binding protein Pput_0988
Pseudomonas
MRLIIVSGRSGSGKSTALDVLEDSGFYCIDNLPAGLLPQLAENALINTELLQPKVAVSIDARNLPSHLMRFPELLEEARARHIQCDVLYLDADEEVLLKRFSETRRRHPLTNANRSLAEAIRVESDLLGPIADLADLKIDTTNLNLYQLRDSIKLRLLNQPEPGTAFLVESFGFKRGMPVDADLVFDVRCLPNPYWKPELREHSGLDQPVIDYLAAQPDVEDMYNDISSYLLKWLPRFAASNRAYVTIAIGCTGGHHRSVYITERLGQQLQQTLKNVQVRHRDL
Displays ATPase and GTPase activities.
A5VZ39
P94123
ACP_AZOBR
Acyl carrier protein
Azospirillum
MSDVAERVKKIVVDHLGVEESKVTENASFIDDLGADSLDTVELVMAFEEEFGCEIPDDAAEKILTVKDAIDFIKANAAA
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
P94123
Q5M2R5
EFP_STRT2
Elongation factor P
Streptococcus
MIEASKLRAGMTFVTNDGKLLKVLEASHHKPGKGNTIMRMKLRDVRSGSTFDTSYRPEEKFEQAIIETVPAQYLYQMDDTAYFMNTETYDQYEIPVVNVQEELKFILENSDVKIQFYGTEVIGVQVPTTVELTVTETQPSIKGATVTGSGKPATLETGLVVNVPDFIEAGQKLVINTAEGTYVSRA
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
Q5M2R5
Q1ACI4
PETL_CHAVU
Cytochrome b6-f complex subunit VI
Chara
MFTVISYLSLLFISFLFALTLFIVLNKIELI
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex.
Q1ACI4
Q92I62
LSPA_RICCN
Signal peptidase II
spotted fever group
MLPLLKKLYLTFARSSRIIITLVIIDQLSKWWFIDNLRWKSGLMLKVTSFLNMVYTWNYGISFGLMREYYQYSNAIFLITNTIIVCYLYYLMIRSKTIGSFAGYSFVIGGAVGNLIDRFFRGAVFDFIHFHYQNYSFPVFNLADCFIIIGVIILIEDYYSTKKVIEEKAKGNYDNAQIEAMAEKIRNTDKGGNDKIASLQN
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Q92I62
Q3BWY7
EFG_XANC5
Elongation factor G
Xanthomonas
MARTTPIERYRNFGIMAHIDAGKTTTSERILFYTGVSHKIGEVHDGAAVMDWMEQEQERGITITSAATTAFWSGMDKSMPQHRFNIIDTPGHVDFTIEVERSLRVLDGAVFVLCAVGGVQPQSETVWRQANKYSVPRMAFVNKMDRTGANFDKVVEQLKARLGAYAVPMQVPIGAEDGFEGVVDLLKMKAIHWDTASQGTTFEYRDIPADLVDVATEARSFMVEAAAEASEDLMDKYLNEGDLSEQEILSGLRERTLKVEIVPVFCGSAFKNKGVQAMLDGVVHLLPSPADRPPVQGIDEDEKEDTRAATDTAPFSALAFKIMTDPFVGSLTFFRVYSGTLNSGDQVYNPVKSKKERVGRILQMHSNNREEIKEVRAGDIAAAVGLKDVTTGDTLCAQDKIITLERMVFPEPVISMAVEPKTKSDQEKMGMALGRLAQEDPSFRVKTDEESGQTIISGMGELHLDIIVDRMRREFNVEANVGKPQVAYRETIRKSDVKSDYKHAKQSGGKGQYGHVVIELSPMTEEERKSENVKDDFLFINDITGGIIPKEFIPSVEKGLRETITSGPIAGFPVVGVKVKLVFGSYHDVDSSEMAFKLAASMAFKQGFAKASPVLLEPIMKVEIVSPEDYLGDVMGDVSRRRGVLQGQDDSPSGKIINAMIPLGEMFGYATSLRSMSQGRATFSMEFDHYEEAPANIADAVTKKG
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Q3BWY7
E5KGE0
BRIZ1_ARATH
BRAP2 RING ZnF UBP domain-containing protein 1
Arabidopsis
MFILRVHSVDSERPISVEEEESGFTYASKRAQPPLKLIQPSLKLTDRKGLIHLYRKSSHSSLPNPSSRSTTLFIVAVPNYLSSLDFIRFCDSRISQVSDILFIRNDGMEDRYSVLITFSDQSEADGFYNNLNGKKFAPSEAEVCHILYVMSVEHTEFDEVAAEAPTGFTELPTCPICLERLDPDTSGIVSTLCDHSFQCSCTSKWTYLSCQVCRLCQQQDEILNCSICGKTENVWACLVCGFVGCGRYKEGHSIRHWKETHHCYSLDLRTQQIWDYVGDSYVHRLNHSKIDGKSVEMSTSCLSHQGDCGLCECSEDTGISGAIFNSKVDSIVIEYNDLLASQLKGQRQYYESLIVEARSKQESSIAEAVEQIVVNTMQELQNKIEKCEEEKSGITEVNTKLIKEQDTWRKKAKEIEEREAALLGSKDEMITDLQEQIRDITVFIEAKKTLKKMSSDTDGIREGTVLPVPISPEPVSSVRRQKKSNRRK
RING-type ubiquitin E3 ligase required for seed germination and post-germination growth.
E5KGE0
Q06RC1
RBL_JASNU
Ribulose bisphosphate carboxylase large chain
Jasminum
MSPQTETKASVGFKAGVKEYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPGETDQYICYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPPAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTSEEMIKRAVFARELGVPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGIHFRVLAKALRMSGGDHIHSGTVVGKLEGERDITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVKARNEGRDLASEGNVIIREAAKWSPELSAACEVWKEIRFDFKAVDTLDPEK
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
Q06RC1
Q12MI8
SYM_SHEDO
Methionyl-tRNA synthetase
Shewanella
MTQSQRKILVTSALPYANGPIHLGHMLEYIQTDIWSRFQKMRGHECHYICADDAHGTPIMLKAQQLGIAPEAMIAQVQIEHEQDFADFNVAFDNFHSTHSEENRELASDIYIKLRDAGHIKTKTISQLYDPEKSMFLPDRFVKGTCPKCKSDDQYGDNCDSCGATYSTTDLINPRSAVSGATPVMKDTEHFFFDLPAFEGMLKEWIHSGSLQSEMANKLNEWFEQGLQQWDISRDAPYFGFEIPDAPGKYFYVWLDAPIGYMGSFKNFCAKRGDINFDDFWAKDSTAEVYHFIGKDIVYFHSLFWPAMLEGAGLRKPTSVYAHGYVTVNGAKMSKSKGTFIKARTYLDHLDPEYLRYYYAAKLSSRIDDLDLNLEDFAQRVNSDLVGKLVNLASRTAGFISKRFDGKLANVTDNSLAESFIAKQEVIAEFYEAREYGKAMREIMAMADIANGFVAEQAPWQLVKDDDKQAQAHEVCSIALNLFRILTTYLKPVLPRLSQDVEAFMQLELTWDNLAKDMTAHEIAPFKAMMQRVDLDKVAAMVDASKDNLQPTEAPKADKKADKKVEKKATTGDPLTDDPISDEISFEDFAKLDLRIALIAKAEHVADADKLLKLQLDLGGVTKQVFAGIKSAYAPEDLEGKLTVMVANLAPRKMRFGMSEGMVLAAGPGGDELWILEPHQGAKPGMRVK
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
Q12MI8
A0KQA8
RL1_AERHH
50S ribosomal protein L1
Aeromonas
MAKLSKRMRVIREKVDGTKEYSINEAIALLKELATAKFVESVDVAVNLGIDARKSDQNVRGATVLPHGTGREVRVAVFTQGANAEAAKAAGAELVGMDDLADLVKKGEMNFDVVIASPDAMRVVGQLGQILGPRGLMPNPKVGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTLGKVSFNEVQLKENLEALLVALKKAKPSSAKGVFIKKVSISTTMGAGVAVDQASLEAQA
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
A0KQA8
Q5KXJ2
SP2AB_GEOKA
Stage II sporulation protein AB
Geobacillus thermoleovorans group
MRNEMHLQFSARSENESFARVTVAAFVAQLDPTMDELTEIKTVVSEAVTNAIIHGYNNDPNGIVSISVIIEDGVVHLTVRDEGVGIPDIEEARQPLFTTKPELERSGMGFTIMENFMDEVIVESEVNKGTTVYLKKHIAKSKALCN
Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
Q5KXJ2
Q110M9
PYRG_TRIEI
UTP--ammonia ligase
Trichodesmium
MTKFVFITGGVVSSIGKGIVAASLGRLLKSRGYSVSILKLDPYINVDPGTMSPFQHGEVFVTEDGAETDLDLGHYERFTDTSMSRLNSVTQGSIYQAVINKERRGDYQGGTVQVIPHITNEIKERIHRVAKNANPDVVITEIGGTVGDIESQPFLEAIRQFRKDVRRNNALYIHVTLVPWIASAGEMKTKPTQHSVKELRSIGIQPDILVCRCDRKLSEGLKEKMSEFCDVPVESVITSQDAQSIYEVPLMLETEGLAVQALELLKMEQRQPNLSHWKTLVNRLYHRDKQDIRTSQGKLSITATVEIAIVGKYIQLSDAYLSVVEALRHAAIAVGVDLNLHLVNAEDVETKGARTYLEKANGIIVPGGFGVRGIDGKIATVEYARINKIPFLGLCLGMQCAVIEWARNIAKLDAAHSFEFDPQTPNPVINLLPEQQDVVDLGGTMRLGLYPCRLQGDTLAFKTYQQEVIYERHRHRYEFNNAYRNLFKETGYIISGTSPDGRLVEIIELPAHPFFIATQFHPEFQSRPSTPHPLFHNFFQAANSQEKCDNLSVNNTEETPDNLVSKSSIPN
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Q110M9
Q8S0G4
GPDH1_ORYSJ
Probable glycerol-3-phosphate dehydrogenase [NAD(+)] 1, cytosolic
Oryza sativa
MVGSVHVNGSVNGGNGTEERLDELRRLLGKSDGDLLKIVGIGAGAWGSVFAALLQDAYGRFREKVQIRIWRRAGRSVDRTTAEHLFEVINSREDVLRRLIRRCAYLKYVEARLGDRTLYADEILRDGFCLNMIDTPLCPLKVVTNLQEAVWDADIVVNGLPSTETREVFEEISKYWKERISVPVIISLAKGIEASLDPIPRIITPTQMISSATGVPTENILYLGGPNIASEIYNKEYANARICGSNKWRKPLAKFLRQPHFIVWDNSDLVTHEVMGGLKNVYAIGAGMVAALTNESATSKSVYFAHCTSEMIFITHLLTEQPEKLAGPLLADTYVTLLKGRNAWYGQMLAKGELSPDMGDSIKGKGMIQGISAVGAFFELLSQPSLSVQHPEENKQVAPAELCPILKRLYRILIKRELSTRDILQALRDETMNDPRERIEMAQSHAFYRPSLLGKP
May be involved in cell redox homeostasis.
Q8S0G4
Q6QT55
ANDR_MACMU
Nuclear receptor subfamily 3 group C member 4
Macaca
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLQQQQQQQQETSPRQQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSAPECHPERGCVPEPGAAVAAGKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLEGTSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPVLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGAGEAGAVAPYGYTRPPQGLAGQEGDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETAQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.
Q6QT55
Q9SAC9
AP1M1_ARATH
Mu1-adaptin 1
Arabidopsis
MAGAASALFLLDIKGRVLVWRDYRGDVTAAQAERFFTKLIETEGDSQSNDPVAYDNGVTYMFVQHSNIYLMIASRQNCNAASLLFFLHRVVDVFKHYFEELEEESLRDNFVVVYELLDEMMDFGYPQFTEARILSEFIKTDAYRMEVTQRPPMAVTNSVSWRSEGLKFKKNEVFLDVIESVNILVNSNGQIVRSDVVGALKMRTYLSGMPECKLGLNDRILLEAQGRAIKGKAIDLEDIKFHQCVRLARFENDRTISFIPPDGSFDLMTYRLSTQVKPLIWVEAHIERHSRSRVEMLVKARSQFKDRSYATSVEIELPVPTDAYNPDVRTSLGSAAYAPEKDALVWKIQYFYGNKEHTLKADFHLPSIAAEEATPERKAPIRVKFEIPKFIVSGIQVRYLKIIEKSGYQAHPWVRYITMAGEYELRLM
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting at the trans-Golgi network and early endosomes (TGN/EE). The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Functions redundantly with AP1M2 in multiple post-Golgi trafficking pathways leading from the TGN to the vacuole, the plasma membrane, and the cell-division plane.
Q9SAC9
Q87SA6
MUTH_VIBPA
Methyl-directed mismatch repair protein
Vibrio
MKPEPQSEAELMERAHDIAGLSFAELADEAGMTVPENLKRDKGWVGQLLEWHLGAPAGSKPQQDFSKLGIELKSIPIGYNGRPLETTFVCVAPLTGVQGLTWETSHVRNKLSRVLWVPVEGEREIPLAERRVGTPLIWSPDKEEEQILRNDWEELMEMIVFGKFDQISARHGEALHLRPKAANAKALTEAYSSNGKPMKTLPRGFYLRTQFTEQILLKHYINVQSE
Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair.
Q87SA6
B6EJA2
TRPA_ALISL
Tryptophan synthase alpha chain
Aliivibrio
MDRYQALFAKLAEKNQGAFVPFVTIGDPNPELSYEIMDTLVKAGADALELGIPFSDPLADGPTIQGANIRALNSKTTPIVCFDLIAKIRAKYPETPIGLLVYANLVFANGIDTFYTKCQQAGVDSVLIADVPTNESEEFRTSAIKHNVHPIFIAPPSASDETLETVAKLGGGYTYLLSRAGVTGAETKAGMPVAQLLARLNQFDAPPAILGFGISEPAQVEEAIKAGAAGAISGSATVKIIEQHQDNPAALLDALTAFTSAMKAATQK
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
B6EJA2
A9BEF8
ACCA_PROM4
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Prochlorococcus
MARRYLLEFEKPLVELEKQIEQIRELARDSEVDVSQQLLQLETLAARRREEIFNALTPAQKIQVARHPQRPSTLDFIQMFCDDWVELHGDRNCSDDKALIGGIARIEEKSVLVIGQQKGRDTKENVARNFGMAKPGGYRKALRLMNHADRFKLPIISFIDTPGAYAGLLAEEQGQGEAIAVNLREMFRLRVPIISTVIGEGGSGGALGIGVADRLLMFEHSVYTVASPEACASILWRDAGKAPDAAAALKITGSDLMALGIVDEVLSEPSGGNNWAPLKAGEVLKESLIRNLRELDSLSIRQLRDKRYEKFRQMGRFLEPSSLDEELIT
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
A9BEF8
Q139A7
MIAA_RHOPS
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Rhodopseudomonas
MFGLQMSVATSDMNGSDPGQPGQRPAAVLIAGPTASGKSALALRLAQARDGVVINTDSMQMYRDLRIITARPTAEEEALAAHRLYGSVDAAVNFSAGAYVEAAAGALAEARAAGRLPIFVGGTGLYFKALTRGLSAVPPVAAEVRDAVRLRLDRDGVLALHAELARHDPAGAARLAPADRSRIARALEVVLATGRPLADWHNQASPPLLPPEGFVAMFLAPEREALYGRIDARFAAMLQAGALEEVAALAARNLDPLLPAMKAHGVPALIRHFRGELSLEEAAAIGAADTRHYAKRQFTWFRHQLPEFRWVTPEQAESGLLGT
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Q139A7
P84614
SCX28_HOTTS
Alpha-toxin Bs-Tx28
Mesobuthus
GVRDAYIADDKNCVYTCGSNSYCNTECTKNGAESGYCQWFGRWGNGCWCIKLPDKVPIRIPGKCR
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits the inactivation of activated TTX-sensitive sodium channels (Nav).
P84614
C3MR85
RL10_SULIL
Acidic ribosomal protein P0 homolog
Sulfolobus
MKRLALALKQKKVASWKLEEVKELTELIKNSNTILIGSLEGFPADKLHEIRKKLRGKAIIKVTKNTLFKIAAKNAGISTEKLEQYLTGPNVFIFTKDNPFLTNMFFENYKLRRYAMPGDKAEEEVIIPAGDTGMPAGPILSVFGKLKVQTKVQDGKVHVVKDTVVAKPGDVIPTEALPILQKLGIMPVYVKLKIKVAYHEGLVIPAENLKLNLEGYRSNIAEAYRNAFTLAVEIAYPVPDVLKFTINKIFKNAITLASEIGYLTPESAQAVISKAVAKAYALATAISGKVDLGVKLPSAQQTQTQQSTAEEKKEEKKEEEKKGPSEEEIGSGLASLFG
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
C3MR85
A1D8A4
FEN1_NEOFI
Flap structure-specific endonuclease 1
Aspergillus subgen. Fumigati
MGIKHLFQVIQENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRTLEGLGMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIENDPKKKYVIPEDWPYQDARELFLHPDVREADHPECDFKWEAPDVEALVEFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVARTDEEKASLKRKHDEKLQEQKKRKKEEAKAKKEAKAKPRGAA
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
A1D8A4
B4M703
TRMB_DROVI
tRNA(m7G46)-methyltransferase
Drosophila
MVTNSQEGETLPATSSVTGLPQKRFYRQRAHSNPIADHSFDYPARPEDVDWRSLYPNIGSEQQVEFADIGCGYGGFLVTLGEMFPDKLAIGMEIRVKVSDYVIDRIAALRMKNAETSAYQNIACIRTNAMKYLPNYFQKSQLEKMFFLYPDPHFKRAKHKWRIINQALLSEYAYVLRSGGLVYTMTDVEDLHKWIVSHMTQHPLYERLTDEEANADPITPKLYQSSEEGAKVVRNKGDHFLAIFRRI
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
B4M703
P50075
GYRBS_STRNV
DNA gyrase subunit B, novobiocin-sensitive
Streptomyces
MADSGNPNENTPSVATGENGEVTGSYNASAITVLEGLDAVRKRPGMYIGSTGERGLHHLVTEVVDNSVDEALAGHADTIDVTILADGGVRVVDNGRGIPVGIVPSEGKPAVEVVLTVLHAGGKFGGGGYSVSGGLHGVGVSVVNALSTKVAVEVKTDGYRWTQDYKLGVPTRRCAQNEATDETGTTVTFWADPDVFETTEYSFETLSRRFQEMAFLNKGLTLKLTDERESAKAVVGADVAGTDSAETPGEEPVRSVTYYYEGGIVDFVKYLNSRKGDLIHPTVIDIDAEDKERMLSVEIAMQWNSQYSEGVYSFANTIHTHEGGTHEEGFRAAMTGLVNRYAREKKFLREKDDNLAGEDIREGLTAIISVKLGEPQFEGQTKTKLGNTEAKTFVQKIVHEHLTDWFDRHPNEAADIIRKSIQAATARVAARKARDLTRRKGLLESASLPGKLSDCQSNDPSKCEIFIVEGDSAGGSAKSGRNPQYQAILPIRGKILNVEKARIDKILQNTEVQALISAFGTGVHEDFDIEKLRYHKIILMADADVDGQHINTLLLTFLFRFMRPLVEAGHVYLSRPPLYKIKWGRDDFEYAYSDRERDALVELGKQNGKRIKEDSIQRFKGLGEMNAEELRITTMDVDHRVLGQVTLDDAAQADDLFSVLMGEDVEARRSFIQRNAKDVRFLDI
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
P50075
Q9AGA7
PTUCB_KLEPN
PTS system alpha-glucoside-specific EIIB component
Klebsiella
MLSQIQRFGGAMFTPVLLFPFAGIVVGIAIMLRNPMFVGEALTAPDSLFAQIVHIIEEGGWTVFRNMPLIFAVGLPIGLAKQAQGRACLAVLVSFLTWNYFINAMGMTWGHFFGVDFSAEPTAGSGLTMIAGIKTLDTSIIGAIVISGLVTALHNRYFDKPLPVFLGIFQGSSFVVIVAFLAMIPCAWLTLLGWPKVQLGIESLQAFLRSAGALGVWVYIFLERILIPTGLHHFVYGPFIFGPAVVEGGLQVYWAEHLQAFSQSTEPLKTLFPEGGFALHGNSKVFGSVGIALALYFTAAPENRVKVAGLLIPATLTAMLVGITEPLEFTFLFISPLLFAVHAVLAATMATVMYICGVVGNFGGGLLDQFLPQNWIPMFHHHASMMFIQIGIGLCFTALYFVVFRTLILRLNLKTPGREESEIKLYSKADYQAARGKTTAAAAPETRLGQAAGFLQALGGADNIESINNCATRLRIALVDMAKTQSDDVFKALGAHGVVRRGNGIQVIVGLHVPQVRDQLENLMKDSLSTEHTTMTEAVS
Involved in the transport and simultaneous phosphorylation at O-6 of the glucosyl moiety of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses. Can also transport maltose, isomaltose and maltitol, phosphorylating at O-6 of their non-reducing glucose portion.
Q9AGA7
P32198
CPT1A_RAT
Carnitine palmitoyltransferase 1A
Rattus
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPANPSSWLIVVVGVISSMHAKVDPSLGMIAKISRTLDTTGRMSSQTKNIVSGVLFGTGLWVAVIMTMRYSLKVLLSYHGWMFAEHGKMSRSTKIWMAMVKVLSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEEDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPLMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTLDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHIKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDPSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPVVGHLWEYVMATDVFQLGYSEDGHCKGDTNPNIPKPTRLQWDIPGECQEVIDASLSSASLLANDVDLHSFPFDSFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTMESCNFVQAMMDPKSTAEQRLKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKNPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTINSKK
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion . Plays an important role in hepatic triglyceride metabolism .
P32198
Q0T2F6
AROC_SHIF8
5-enolpyruvylshikimate-3-phosphate phospholyase
Shigella
MAGNTIGQLFRVTTFGESHGLALGCIVDGVPPGIPLTEADLQHDLDRRRPGTSRYTTQRREPDQVKILSGVFEGVTTGTSIGLLIENTDQRSQDYSAIKDVFRPGHADYTYEQKYGLRDYRGGGRSSARETAMRVAAGAIAKKYLSEKFGIEIRGCLTQMGDIPLEIKDWSLVEQNPFFCPDPDKIDALDELMRALKKEGDSIGAKVTVVASGVPAGLGEPVFDRLDADIAHALMSINAVKGVEIGDGFDVVALRGSQNRDEITKDGFQSNHAGGIFGGISSGQQIIAHMALKPTSSITVPGRTINRFGEEVEMITKGRHDPCVGIRAVPIAEAMLAIVLMDHLLRQRAQNADVKTDIPRW
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Q0T2F6
Q3IDE8
RECF_PSET1
DNA replication and repair protein RecF
Pseudoalteromonas
MSLSHLSLKYFRNIEALTLEPVNGVNIIYGENGSGKTSLLEAIYYLSHGKSFRTSKHKSIIAHQQEQFVIHGRKAIHDLSIPIGISKTQAGETNLKIQGKASRKISELAQLMPVQIITPESYSLFFGGPKERRKFLDLGLFHVEHEFFFLWQSFNKVLKQRNALLKSKPKNYFDQIKFWDKEFVRLAEQINKLRMAYISRFKQQFFDKMCAELTLIRDLEISFNAGWKESESLSDALELNFERDARQGFTSKGPHKADFSFSVAGSSVENIFSRGQLKLLLYALKVTQNSLIESETDKQSILLIDDLPSELSEDTKEKVGQLLAHCSSQIFISSILSESISAVVEPMQRELQMFHVKHGNLITR
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Q3IDE8