accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q9UZP8
GCST_PYRAB
Glycine cleavage system T protein
Pyrococcus
MAKRVHLFDWHKEHAKKIEEFAGWEMPIWYSSIKEEHLAVRNAVGLFDVSHMGEIYFRGKDALKFLQYVTTNDISKPPAISGIYTLVLNERGAIKDETLIFNMGNNEYLMICDSDAFEKLYAWFTYLKKTIEQFTKLDLEIELKTYDIAMFAVQGPKARDLARDLFGIDINEMWWFQARWVELDGIKMLLSRSGYTGENGFEVYIEDANPYHPDESKRGEPEKALHVWERILEEGKKYGIKPAGLGARDTLRLEAGYTLYGNETKELQLLSTDIDEVTPLQANLEFAIYWDKDFIGKDALLKQKERGLGRKLVHFKMVDKGIPREGYKVYANGELIGEVTSGTLSPLLNVGIGIAFVKEEYAKPGIEIEVEIRGARKKAITVTPPFYDPKKYGLFRET
The glycine cleavage system catalyzes the degradation of glycine.
Q9UZP8
Q94819
TE95_TETTH
Telomerase component p95
Tetrahymena
MSRRNQKKPQAPIGNETNLDFVLQNLEVYKSQIEHYKTQQQQIKEEDLKLLKFKNQDQDGNSGNDDDDEENNSNKQQELLRRVNQIKQQVQLIKKVGSKVEKDLNLNEDENKKNGLSEQQVKEEQLRTITEEQVKYQNLVFNMDYQLDLNESGGHRRHRRETDYDTEKWFEISHDQKNYVSIYANQKTSYCWWLKDYFNKNNYDHLNVSINRLETEAEFYAFDDFSQTIKLTNNSYQTVNIDVNFDNNLCILALLRFLLSLERFNILNIRSSYTRNQYNFEKIGELLETIFAVVFSHRHLQGIHLQVPCEAFQYLVNSSSQISVKDSQLQVYSFSTDLKLVDTNKVQDYFKFLQEFPRLTHVSQQAIPVSATNAVENLNVLLKKVKHANLNLVSIPTQFNFDFYFVNLQHLKLEFGLEPNILTKQKLENLLLSIKQSKNLKFLRLNFYTYVAQETSRKQILKQATTIKNLKNNKNQEETPETKDETPSESTSGMKFFDHLSELTELEDFSVNLQATQEIYDSLHKLLIRSTNLKKFKLSYKYEMEKSKMDTFIDLKNIYETLNNLKRCSVNISNPHGNISYELTNKDSTFYKFKLTLNQELQHAKYTFKQNEFQFNNVKSAKIESSSLESLEDIDSLCKSIASCKNLQNVNIIASLLYPNNIQKNPFNKPNLLFFKQFEQLKNLENVSINCILDQHILNSISEFLEKNKKIKAFILKRYYLLQYYLDYTKLFKTLQQLPELNQVYINQQLEELTVSEVHKQVWENHKQKAFYEPLCEFIKESSQTLQLIDFDQNTVSDDSIKKILESISESKYHHYLRLNPSQSSSLIKSENEEIQELLKACDEKGVLVKAYYKFPLCLPTGTYYDYNSDRW
Ribonucleoprotein DNA polymerase that catalyzes the de novo synthesis of telomeric simple sequence repeats. Subunit p95 contains some or all of the template-independent primer DNA-binding site termed the anchor site.
Q94819
P0CS81
TRMB_CRYNB
tRNA(m7G46)-methyltransferase
Cryptococcus neoformans species complex
MEAGPSTASPGVSVSPAPALTAGEVQLLKVPQKRFYRQRAHANVFIDHELDYPKRPELMDWSTHYPAYFSQPNEDGTITQGEKKVEWADVGCGFGGLLMALAPLFPEKLMLGMEIRTSVTKYVTDRIAATRQAQSLLPADSVDTKPGGYQNVSVIKANSMKHMPNFFAKGQLEKIFFLFPDPHFKNRKHKARIITPALLAEYAYVLRPGGILYTVTDVKDLHEWMAHHLHAHPLFEYIPTETLSDDPILEAARTATEEGQKVERNKGDKWVACFRRKEDPKEEDED
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
P0CS81
Q332T7
RK22_LACSA
50S ribosomal protein L22, chloroplastic
Lactuca
MLNKRTTEVYALGQHISMSAHKARRVIDQIRGRSYEETLMILELMPYRACYPIFKLVYSAAANASFNMGSNEVNLVISKAEVNEGTIVKRLKPRARGRSFAIQKPTCHITIVMKDISLDEYIDTDSITWSQKPKSKKKHTTMSYYDMYSNGGTWDKK
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Q332T7
Q8BJ34
MARF1_MOUSE
Meiosis arrest female protein 1
Mus
MEGKGTENPCSRTLGWFHQDNDAKPWLWKFSGCFSRPEQTLPLSSQTKEYMENKKAAVELKDIPSPLHVGSKFFPAVPLPDIRSLQQPKVQLSAIPKVSCCAHCPNEPSTSPMRFGGGSGSSGGSGSLIHTGSLLDSPSTGTVTCQVGSGFAFQSVSSLQNASTRNNLVGLSSDFPSMCVESNLPSCKHLSCCGKLHFQSCHSNVHKLHQFQNLQGCASAGYFPCSDFPSGAPGHLEERLSHSELTPHLCTNSLHLNVAPPVCLKGSLYCEDCLNKPARNSIIDAAKIWPNIPPPSTQPAPPAIPVCNGCGTKGMEKETSLLLATSLGKTASKFGSPEVAVTGQVLETLPPIGVFWDIENCSVPSGRSATTVVQRIREKFFRGHREAEFICVCDISKENKEVIQELNNCQVTVAHINATAKNAADDKLRQSLRRFANTHTAPATVVLVSTDVNFALELSDLRHRHGFHIILVHKNQASEALLHHANQLIRFEEFISDLPPRLPLKIPQCHTLLYVYNLPANKDGKSISNRLRRLSDNCGGKVLSITGCSAILRFINQDSAERAQKRMENEDVFGNRIIVSFTPKHREFFEAKSSNAIADKVKSPKKVKNTKLCLIKDTSEQSPSVKAMPGKVLQANSGSATKTTNIKSLQELCRMESKSGNRNSDHQQGHGRLAALPNSGPTASVPIVKNTGVTEPLYRSSQKKENPSSQSTVNSPVEKKKREETVFQVSYPSAFSKLIASRQVSPLLTSQSWSPRASPLAFNIANPSSGADCPDPFANGVDIQVSNVDYRLSRKELQQLLQEAFSKHGQVKSVELSPHTDYQLKAIVQMRNLHEAICAVNSLHRHKIGSKKILVSLSTGAANKSLSLLSTETMSILQDAPACCLPLFKFIDIYEKKYGHKLNVSDLYKLTDTIAIREQGNGRLVCLLPSNQARQSPLGSSQSHDGSSSNCSPVLFEELEYHEPVCKQHCSNKDFSELVFDPDSYKIPFVVLSLKVFAPQVHSLLQTHQGTVPLLSFPDCYAAEFGDLEITQDSHKGVPLEHFITCIPGVNIATAQNGVKVVKWIHNKPPPPNTDPWLLRSKSPVRNPQLIQFSREVIDLLKTQPSCILPVSNFIPSYHHHFGKQCRVSDYGYSKLIELLEAVPHVLQILGMGSKRLMTLTHRAQVKRFTQDLLKLLKSQASKQVIVRDFSQAYHWCFSKDWDVTEYGVCDLIDIISEIPDTTICLSQQDDDMVICIRKRERTQDEIERTKQFSKDVVDLLRHQPHFRMPFNKFIPSYHHHFGRQCKLAYYGFTKLLELLEAIPEILQVLECGEEKILTLTEVERFKALAAQFVKLLRSQKGNCLMMTDLFTEYAKTFGYTFRLQDYDVSSVSALTQKLCHVVKVADMESGKQIQLINRKSLRSLTAQLLVLLMSWEGDAYLPVDELRRHYETTHSTPLNPCEYGFMTLTELLKSLPYLVEVCTNDKAEEYVKLTSLYLFAKNVRSLLHTYHYQQIFLHEFSMAYNKYVGETLQPKTYGYSSVEELLGAIPQVVWIKGHGHKRIVVLKNDMKNRLSSFDLFSVNHEDQPAVSRQILAVPESHLASELQLRTGTGPSQMEQELLHLASSSPVDLLCAPVPSCLPSPQLRPDPVILKPADLIQFEEHPQEPLGVLVLNQEEKSEVPLPVQKGNLSCDSSPSSPAASPAPPGPSSEAPRPLFSKDAVESPAKKQPKNRVKLAANFSFAPVTKL
Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks.
Q8BJ34
Q5R0C0
LOLA_IDILO
Outer-membrane lipoprotein carrier protein
Idiomarina
MKAVVFAMVMAVSFNVFASGDESDKQALQSLLKQTQSLSAEFEQQVKDEQGEVLQTLSGTLKLKRPANLYWHTKEPDESVMVANGKKVWYYNPFVEQVTIYAQQDMVDDSPLLLVLNSNGNQWQNYNVSFRDNRYFVEHQTNGSKLELRFTDEKLTEITMVQAQGERTELMLNNVALNETISDEQFVFDVPADVDVDDQS
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
Q5R0C0
A7IID0
EFP_XANP2
Elongation factor P
Xanthobacter
MVKVIASSLRKGNVVDIDDKLYVVLTAENIHPGKGTPVTQLDMRRISDGVKISERYRTTEQVERAFVEDRPHTFLYEDSDGYTFMNPENFDQVIVTKDVMGDSAVYLQEGMECMLSTHNGVPIAIELPARVTLEIVDTEPTVKGQTASSSYKPAKLSNGVRTMVPPHISAGTRVVIMTADNSYVERAKD
Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.
A7IID0
Q03298
PHHY_ACIAD
4-hydroxybenzoate 3-monooxygenase
Acinetobacter
MQTMKTKVAIIGSGPAGLLLGQLLYKAGIEHVIVEQRSADYVASRIRAGILEQVSVDLLEQAGVDQNLKEKGLPHSGIEILTNGQKFRVDLSALTQGKQVTVYGQTEVTKDLMQAREQAGLCSFYESNDVQIHDFYNAPKVTFESNGTHYQIECDFIAGCDGYHGVCRASVPQDKIKTFEKVYPFGWLGVLADVPPVADELIYVQSERGFALCSMRSETRSRYYIQVPLTDHVENWSDDQFWEELKNRLDPESCEKLVTGPSIEKSIAPLRSFVTEPMRFGKLFLAGDAAHIVPPTGAKGLNLAASDIAYLSSALIEFYTQGSEQGIDQYSEKCLQRVWKAERFSWWMTHLLHRFETESEFDHKIKQAELSYILGSTAGQTTLAENYVGLPYEIKSLDYLKHAS
Catalyzes the incorporation of an atom of dioxygen into p-hydroxybenzoate (p-OHB) to form 3,4-dihydroxybenzoate (3,4DOHB). The reaction occurs in two parts: reduction of the flavin adenine dinucleotide (FAD) in the enzyme by reduced nicotinamide adenine dinucleotide phosphate (NADPH) in response to binding p-hydroxybenzoate to the enzyme and oxidation of reduced FAD with oxygen to form a hydroperoxide, which then oxygenates p-hydroxybenzoate.
Q03298
A2BZG2
SYA_PROM1
Alanyl-tRNA synthetase
Prochlorococcus
MEKSSSSSINPPSLSGDEIREAFINFFVQHNHQKLASSSLIPDDPTVLLTIAGMLPFKPIFLGLKESSTPRATSSQKCIRTNDIENVGRTARHHTFFEMLGNFSFGDYFKKEAIQWAWELSTEVFRLNPQNIVISVFKEDLEAEQIWKEVVGVDANRIIRMGAADNFWSSGATGPCGPCSELYFDFKPELGSDEIDLEDDSRFIEFYNLVFMQYNRDLEGNLEPLANCHIDTGMGLERMAQILQKKSNNYETDLIFPLIKAAALLAQLEYETTNKKNKTSLKIIGDHCRAVTHLICDGVSASNLGRGYILRRLIRRMIRHGRLVGIVQPFLPQLAEMAIELMKNAYPQLLEKKKIILNELKIEESRFLETLERGEKLLAEITSHECDLISGAQAFELYDTYGFPLELTEEIANEKGISVDINGFENEMAKQRKRAKEASVSIDLTEEGSIEREISLFDETRFEGYEKLETTSTVIGIFKNNESVKQAVQGDLVKIIVNRTPFYAESGGQIGDKGIITSQDLEVSVENVRKKKNIFIHSGIVNTGVLEINSSVQMNVTPSFRQRTTSNHTATHLLQSALKLSIDSSVSQRGSLVSNHRLRFDFNAPKPLTIKELEDMEVRINQWINEDHPIQIKTMPIKEAMAAGALAMFGEKYGDVVRVVDVPGVSMELCGGTHVTRTSQLGTFKIINETGIASGIRRIEAIAGPSVLDYFNERDLVVKELSKSFKVQSYEIVERVSSLQLELKDKTKELIKVKNDLALAKALGLASYAKSVGKSKLLIRRLDGVDGSGLQSAASSLIDHLGKYSAVIFGGIPNQEIDNKLVFVAAFSPDLVSDGLHAGKFISGVAKMCGGGGGGRPNLAQAGGSQPQSLDLALEKANENLTQQLS
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
A2BZG2
Q9NRP4
SDHF3_HUMAN
Succinate dehydrogenase assembly factor 3, mitochondrial
Homo
MPGRHVSRVRALYKRVLQLHRVLPPDLKSLGDQYVKDEFRRHKTVGSDEAQRFLQEWEVYATALLQQANENRQNSTGKACFGTFLPEEKLNDFRDEQIGQLQELMQEATKPNRQFSISESMKPKF
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.
Q9NRP4
A5FRY5
RL14_DEHMB
50S ribosomal protein L14
Dehalococcoides
MVQQYTRLNVADNTGAKKIMCINVLGGSHKIQAKVGDVIVAAVKKSSPDAQAKSGTVVKAVVVRITKPYARPDGSYIKFDDNAAVILNDKMEPKGTRIFGPVARELRDKKFTKILSLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
A5FRY5
B9KIX1
NTPP_ANAMF
Nucleotide pyrophosphatase
Anaplasma
MLKIEGLVLASSSKYRLALLEQIGVVPGEVVSPNIDESLLKGELPRRYCMRMARTKADAVAALRSDKFVLGADTVAYCGKRVLSKTESEDCAVRYLEMLSGRRHRVCTSVCLRSPGGIVHERSVVSVVKFKSMSKGEIEYYISSGQWRGKAGGYGIQGFAGALISWIQGSYSSIAGLPLHETYCLLCGYFDLKHIP
Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
B9KIX1
Q73M28
VATA_TREDE
V-ATPase subunit A
Treponema
MTKTKGKVVGINGNMISVSFEGLVTLNEVGYVEVGSKKLKSEVIRIRGEVAQLQVFEITKGIKVGDIVEFTGDLLSVELGPGLLGQVYDGLQNPLPELAEQAGYFLERGIYLNALSRTAKWHFTPSAKEGDTLKRADLLGTVPEGSFTHRIMIPFNMYGTYKLKSIKPEGDYTVDDTIAEVTDERGNVIPLTMSFKWPVKRAIDCYAERLKPTETLVTKMRTMDTFFPVAKGGTYCIPGPFGAGKTVLQHATSRNADVDIVIIAACGERAGEVVETLTEFPELKDPKTGRTLMERTIIICNTSSMPVAAREASVYTGVTLAEYYRQMGLDVLLLADSTSRWAQALREMSGRLEEIPGEEAFPAYLESYIAAFYERAGIVRLSDGSKGSVTIGGTVSPAGGNFEEPVTQATLKVVGAFHGLSRERSDARKYPAIHPLDSWSKYPSVLPLEQVKYGRSFLRRGTEVEQMMKVVGEEGTSIEDFIIYLKGDLLDAVYLQQNSFDKVDDAVSVERQQHIYNILIEILGTSFKFVSKDEARSYFSKLKLMFIDYNYSPWGSDAFKSHEDGIKKHIAEKADSLDERAKKLLKQAV
Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.
Q73M28
Q4ZWE0
ENO2_PSEU2
2-phosphoglycerate dehydratase 2
Pseudomonas syringae
MKTQIQAIHAREILDSRGNPTVEVDVTLECGAMGRASVPSGASTGAHEAVELRDKDTQRYSGKGVLKAVSNVNTEILESLRGMNAIDQEQIDHLMIKLDGTSDKSRLGGNAILGVSLAVARAAASALNLPLFQYLGGEQAARMPVPMFNILNGGVHANWQGPDFQEFMIAPTGAGSFKEALRWGSEVYHELKAVLKDAGYSTAVGDEGGFAPALKKNSDAIELIIKAIERAGYTPGSQIEIAIDPASSGFYENGLYHLRSEGRKVDAQELINLYSSWVDKYPIAVLEDGLAEDDWSGWKLLNAALGDRIELVGDDLFVTNVERIQRGITENVANAVLIKPNQIGTLTETKAAIEMAYGANWGAMVSHRSGETVDSSIADLTVAMGTGHLKTGAPCRGERVEKYNQFLRIEEDLGSRAFYAGHDAFVR
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
Q4ZWE0
O07838
DCTM_RHOCA
C4-dicarboxylate TRAP transporter large permease protein DctM
Rhodobacter
MSALIIFGLLIALMLTGMPISISLGLTVLTFLFTMTQVPIDTVALKLFTGIEKFEIMAIPFFILAGNFLTHGGVAKRMINFATAMVGHWHGGLGLAGVIACALFAAVSGSSPATVVAIGSVILPAMVNQGFPKQFGAGVITTSGALGILIPPSIVMVMYAVATSGMVVTGPDGQPVSSASVGELFMAGVVPGLMLAGFLAFTTWNRARKFGYPRLEKASLRQRWTAFREAAWGLMLIVVVIGGIYAGIFTPTEAAAMSAVYAFFISVFVYKDLTLRDVPRVLLSSANMSAMLLYIITNAVLFSFLMAHEGIPQALGEWMVNAGLSWWMFLIIVNILLLAAGNFMEPSSIVLIMAPILFPVAVRLGIDPVHFGIMIVVNMEVGMCHPPVGLNLYVASGITKMGITELTVAVWPWLLTMLAFLVLVTYVPAISLALPNLLGM
Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake.
O07838
A1K962
GLPK_AZOSB
Glycerokinase
Azoarcus
MSYVLALDQGTTSSRAMVFDAAGRVRSVARRDFTQSFPQPGWVEHDPAEILRSQFDCARDALADAGLRAGQLAAIGIANQRETTVLWERASGRALAPAIVWQDRRTAAKCAELRARGVWSEALRERTGLELDPYFSATKLAWLLDHVPDARRRAEAGELAFGTVDSWLVWHLSGGRLHVTDHGNAARTLLLDIHRRDWDDALLALFDIPRAVLPRLVDSIGVCGESDPAVLGAAVPIAGIAGDQQAATFGQHCFAPGMAKNTYGTGCFLLMNTGATPVKSSHRLLSTVGWTQGAAHTYALEGSIFMGGATVQWLRDGLGLIREAAEVEALAARVPDSGGVVLVPAFTGLGAPYWDAAARGALFGLTRGSGPAHIARAALDAIALQTDDLVRAMTADGAGPLHELRVDGGAAANNLLMQLQADMLGVAVVRPRMLETTALGAACLAGIGAGVWRDTDALAPHWQIDRVFTPAWSEDQRGAVRARWADAVARSRAWAA
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
A1K962
P0DUH2
HSTX9_HAESL
Peptide HSTX-IX
Haemadipsa
MKTLLVFLLLAILVAVLIGNSQVEACNDNAQCGPLGACIMGYFLPIG
Leech salivary gland peptide with unknown function.
P0DUH2
D7UPN2
ACTS2_ALTAL
ACT-toxin biosynthesis protein S2
Alternaria alternata complex
MLTRRALVVQSQGEVQVEEIPLPTLRDEYITVKVKAVALNPGDWKMLYGPHATPGSILGCDYSGVVEKVGRAVNALLTPGDRVAGFAFGGCPYNHDEGGFASYVTAKGDIQAKLSDSISFEDAATLGVGITTVGQAMYQALGLPLPPAIIQEAASILVYGASTATGTLAVQYAKLTGLKVFATASPHNFDLLKKLGADEVFDYRDPECGAKIRTVTNGLLSLVFDTISEGSSPAIWAAAMGAKGGKYTALLPIKNFPRSDVKVTTILGYTALGVKVSDHLPANQKDFEFSAKFWKLSQHLLEKEKIKTHPVGVRQGGIDAIPQGLQDLKNGRVSGVKLVYKID
Trans-enoyl reductase; part of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) ACT-toxins responsible for brown spot of tangerine disease by the tangerine pathotype which affects tangerines and mandarins . ACT-toxins consist of three moieties, 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA), valine and a polyketide . ACT-toxin I is toxic to both citrus and pear; toxin II the 5''-deoxy derivative of ACT-toxin I, is highly toxic to pear and slightly toxic to citrus . On cellular level, ACT-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment . The acyl-CoA ligase ACTT1, the hydrolase ACTT2, the enoyl-CoA hydratases ACTT3 and ACTT6, and the acyl-CoA synthetase ACTT5 are all involved in the biosynthesis of the AK-, AF- and ACT-toxin common 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA) structural moiety . The exact role of each enzyme, and of additional enzymes identified within the AF-toxin clusters have still to be determined . On the other hand, ACTTS1 to ACTTS4 are specific to the tangerine pathotype . The function of ACTTS3 is to elongate the polyketide chain portion of ACT-toxin that is unique to this toxin . The enoyl-reductase ACTTS2 might complement the missing enoyl-reductase (ER) domain in ACTTS3 in the synthesis of the polyketide portion of ACT-toxin . The roles of the nonribosomal peptide synthetases-related proteins ACTTS1 and ACTTS4 have also still not been elucidated .
D7UPN2
A8H3W9
PROQ_SHEPA
RNA chaperone ProQ
Shewanella
MESTEKLTDTNAILAYLYETFPLCFIAEGETKPLKIGLFQDLAERLADDSKVSKTQLRIALRRYTSSWRYLKCVKAGAQRIDLDGNACGELEQEHIDHAAATLKESQDKAKAKRVAQAKSANPAAKTAKKPVKKPVAKRPKPAQSSKPAKEPVVAENLTPAVLTELKPNQRVNVKLGKAPVAGVILDIKKEDVQVQLDSGLTIKVRAEHILL
RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities.
A8H3W9
Q6FT66
NMD4_CANGA
Nonsense-mediated decay protein 4
Nakaseomyces/Candida clade
MNQYNFILDASAFEKGLGNVKRWCQSNGNVDGKKNVYLRFYVPTFTLQELNFLQYRHKSFSAKEALKFIDKLETATSEGQRNHVVIGRKKEEDLRSDLELFIEFPDILDAVTWPTVLSYCTEGQATIDSLNKLPKRFKILLKSCVYKCHLEDDDRIRWILVTEDPQVRKIASQCHIPWCSIVDADSIISKDMNDRSFRDSEKFNSMMLKRGVAKSENMDGKEVIKTNFDQTVYATRGSGKLWTP
Involved in nonsense-mediated decay of mRNAs containing premature stop codons.
Q6FT66
P17120
BIMC_EMENI
Kinesin-like protein bimC
Aspergillus subgen. Nidulantes
MAGPQRATSGLPTRRTTTRQPTRRAGSAIPERQTSTASPAVSTKTAAISRTRTLKSPGEPASVLAKRKERDIEREINEDTSIHVVVRCRGRNEREVKENSGVVLQTEGVKGKTVELSMGPNAVSNKTYTFDKVFSAAADQITVYEDVVLPIVTEMLAGYNCTIFAYGQTGTGKTYTMSGDMTDTLGILSDNAGIIPRVLYSLFAKLADTESTVKCSFIELYNEELRDLLSAEENPKLKIYDNEQKKGHMSTLVQGMEETYIDSATAGIKLLQQGSHKRQVAATKCNDLSSRSHTVFTITVNIKRTTESGEEYVCPGKLNLVDLAGSENIGRSGAENKRATEAGLINKSLLTLGRVINALVDKSQHIPYRESKLTRLLQDSLGGRTKTCIIATISPARSNLEETISTLDYAFRAKNIRNKPQINSTMPKMTLLREFTAEIEKLKAELIATRHRNGVYMSVESYEEMKMENESRRIISEEQRAKIESMESSLRHKVQELLTLTSKFNDLKKDNDDTLAALCSTNDVLQQTDIVLQNTRAQLEEEEMLRCAHEETEHQLQDVGKGLISTLGQTVEDINSLQSKLDRKAELDATNAELWRASSTEVSDVTKRIDQRVEAFQTRHAKLLETTSVKVNEFIATEISNIERTRSDLSEYNRSLDAACNNAKAETSSAHEDMNNVLEEIKDLREEVKSKVGEGLNGLSAAAARISEEVIGEFTQLHSQLHTSFNNLGKDLKSIFETMATHLSEQKNEINRLRAELQSSNRQNIETTHKASAHLAQAIEEEHVAAEAEREILMSQIKALVEESRQKQFARLRAKIDGVRTEISASGDMLEQATTQHDRQIDEWVFKSEQFAKDVNASKDEIRTKLQNDWEAFDQRNSTIRKATESVHKETVRIVDVQVDDMGRQMEALDDFVAKARSQNGRYRDAHIATLDTIATGVRDSYSSIEGRVENLTGRMNQFQQEATHHHATLEESIAPLSNDVRKPLTDLSSSFQNRSLEEYVATGVTPKKRKYDYISVLPSTESHEVLKSRLRTTKEMEVLPFNSDDQLSGPSSSPGGSPSKGFVYNDVEDEVGTHAPTVTNVNPSNTGLREVDANVAARPLVYSTGEKSTDQDGSPVVSPDSATEAEGMNGPPSKRRRSNSVVADTKLPNKMLARRMAGMMEGRENVPPPGISNGRRLRGRPSP
Important role in mitotic dividing cells. Microtubule motor required for spindle body separation.
P17120
Q9MUU4
RK14_MESVI
50S ribosomal protein L14, chloroplastic
Mesostigma
MIQAQSYLNVADNSGAKKIMCIRVLGGSQRKYAAIGDVIIGVVKDSVPNMSLKKSEVVRAVVVRTCKGIRRENGMTIRFDDNAAVVINKDGNPKGTRVFGPVARELRDRNFTKIVSLAPEVL
Binds to 23S rRNA.
Q9MUU4
E7CLN5
SCX7_RHOJU
Putative beta-neurotoxin RjAa7
Rhopalurus
KEGYPVGRDGCKISCVINNNFCKVECQAKWRQSDGYCYFWGLSCYCTNLPDDAQVWDSSTNKCGG
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
E7CLN5
Q5HM25
RPOA_STAEQ
Transcriptase subunit alpha
Staphylococcus
MIEIEKPRIETIEVSEDAKFGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVKYIEIEGVLHEFSAVDNVVEDVSTIIMNIKKLALKIYSEEDKTLEIDVKDEGEVTASDITHDSDVEILNPELKIATVSKGGHLKVRLVANKGRGYALAEQNNTSDLPIGVIPVDSLYSPVERVNYTVENTRVGQSSDFDKLTLDVWTNGSITPQESVSLAAKIMTEHLNIFVSLTDEAQNAEIMIEKEEDQKEKVLEMSIEELDLSVRSYNCLKRAGINSVQELADKSEADMMKVRNLGRKSLEEVKYKLEDLGLGLRKED
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q5HM25
Q1QYD9
BIOD_CHRSD
Dethiobiotin synthase
Chromohalobacter
MTTYFVTGTDTDAGKTLVASGLLALARRRGLTTLGLKPVASGCESTTEGLRNIDALTLQAQSMPTPPYATLNPYAYAPAIAPHLAARRAGRIPTLDALVAHVADPLAEKRDLTLIEGAGGWRVPLNDDEDLAGLAVRLELPVILVVGLELGCLNHARLSAEAIRADGLPLAGWVGNLIDPGLSFDEVADEACYRDNLATLERTLEAPCLGIVPRLAAATPDARAHAAADYLTLPGDA
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Q1QYD9
P14864
EF1A2_MUCCL
Elongation factor 1-alpha
Mucor
MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYNVTVIDAPGHRDFIKNMITGTSQADCAILIIAGGTGEFEAGISKDGQTREHALLAFTLGFRQLIVAINKMDTTKWSQDRYNEIVKEVSGFIKKIGFNPKSVPFVPISGWHGDNMLDESTNMPWFKGWNKETKAGSKTGKTLLEAIDAIEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGTIKAGMVVNFAPAAVTTEVKSVEMHHETLTEGLPGDNVGFNVKNVSVKDIRRGNVCSDSKNDPAKESASFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFSELIEKIDRRSGKKMEDSPKFVKSGDSAIVKMVPSKPMCVEAYTDYPPLGRFAVRDMRQTVAVGVIKAVEKVDKAGKVTKAAAKASKK
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
P14864
Q03U68
SYE1_LEVBA
Glutamyl-tRNA synthetase 1
Levilactobacillus
MSENSTVKKNVRVRYAPSPTGFLHIGNAQSALFNYLFARHYHGTMVLRIEDTDVKRNVPHGEDSQIDNLHWLGIDWDEGPDKPNPKYAPYHQTERQDLYHRYITQLLDQGLAYKDYATEDELTTMRDQQRAAGEAPHYDGRWYGRSVADQQAAEARGLKPSIRLHLPANHEYAWDDIIKGHVAFNSDNMGGDFIIEKSNGMPTYNFAVVIDDYLMDITDVLRGDDHIANTPKQIAVYEALGLKHPNFGHITLIYNPKTRKKLSKRDKETLQFISQYKNQGYLSEAIFNFIAFLGWSPEGEDELFSREELIERYDPARMSKSPAYFDQSKLDWINAAYIKRLDLDDMTDRVLELVDEGQTDVARQVKALQLPDLRTLTSQVCKIYQTEIHQLSEIMDKVLFYVTILQEPLDYDQLRQFDRTATLAVLTAFRKHVQALPVDVATPDFKKMIQTVSQETGVTGRNLYFPLNVAFTGDHSAPQIDEVLRLFANSTIIELLTKAIAHV
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Q03U68
B5QWY1
RHAD_SALEP
Rhamnulose-1-phosphate aldolase
Salmonella
MQNITDSWFVQGMIKATSDAWLKGWDERNGGNLTLRLDEADIAPFATNFHEKPRYIALSQPMPLLANTPFIVTGSGKFFRNVQLDPAANLGVVKIDSDGAGYHILWGLTHDAVPTSELPAHFLSHCERIKATHGKDRVIMHCHATNLIALTYVLENNTALITRKLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKIYSMGGMKQTITREELVALGKRFGVTPLASAVALY
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
B5QWY1
Q8XVK1
ZAPD_RALSO
Z ring-associated protein D
Ralstonia
MILYEYPFNERIRTLLRLEDLFERLDFFLTQEHPLQHHVALTTLFEIVDVAGRADLKSDLLKELDRQRQTLTVLRSNPQIDQEALDAVIAELETASGNLTATHGKAGQLIADNEWLTSIRSRAIIPGGTCEFDLPAYFAWQHHPGERRRADIVKWAQPLVPLRDATMIVLRLLRESGQSGKVIANAGSYQQMLSGRIYQLMQVRLDDVALGFIPEISANKYMLWVRFTQQDGDLRPKPVDADIPFQLKLCNF
Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
Q8XVK1
Q5F8V5
EX7L_NEIG1
Exodeoxyribonuclease VII large subunit
Neisseria
MSDFFHSDVLSVSELNAFAKSILENHLAGLWIAGEVSNLTRAASGHYYFSLKDSRAQVRCAMFKGAAARLAQPLKEGDHIEVAGKISIYEARGEFQITVNEVRLKGLGQLYEAYERLKAQLQAEGAFAAERKKPLPVRPQCIGIVTSLAAAALRDVVTTLKRRAPEIPVIVYPAAVQGAGSGFQIAQAIKTASQRAECDVLIVCRGGGSIEDLRAFNEEPVVRAIEACTIPVVSGVGHETDFTLADFVADVRAPTPTGAAELVSPNRQESLHRLVQAQGRLKTVLEQRYFDASQKLDWLARQIRHPRQKLDEQRASIGKLAQTLSYSMTQNLRAHTARFERQTQALQHCRPDVSVYRQDIVRLQTALPAAFSRLLARRRQSLTAQAALLEAVSPQHILERGFSVVKNTRGQVIRNADVLKQGQKLHITFSDGETDVRVSKEQGQQDLFDCI
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Q5F8V5
Q0HSW6
DXS_SHESR
1-deoxyxylulose-5-phosphate synthase
Shewanella
MSLDISQFPVLAQANTPNELRQLPQALLPQLADELREFLLKSVGMSSGHFASGLGTVELTVALHYVYNTPFDRLIWDVGHQAYPHKILTGRRDRMHTIRQKNGLHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLMVLNDNEMSISENVGALNNHLAQLMSGRLYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPGTLFEELGFNYIGPIDGHDVDALVETLRNMRSLKGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSQFKKPATKPGLPTFSQVFGKWLCDIAEQDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGFKPVVAIYSTFLQRGYDQLIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRCIPNMVIMAPSDENECRQMLYTGYCYDAGPSAVRYPRGSATGATQVEAMTALPIGKGVIKRLGKRIAMLNFGTTLAAALTAAESLDATVVDMRFVKPLDVDLVKEMAQTHDVLVTVEENAIMGGAGSGVLELLQKLKMPKPVLQIGLPDEFIKHGSPEEVTHDLQLDAEGMLAQINAFLAD
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Q0HSW6
Q58DX5
NADL2_HUMAN
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2
Homo
MGENEASLPNTSLQGKKMAYQKVHADQRAPGHSQYLDNDDLQATALDLEWDMEKELEESGFDQFQLDGAENQNLGHSETIDLNLDSIQPATSPKGRFQRLQEESDYITHYTRSAPKSNRCNFCHVLKILCTATILFIFGILIGYYVHTNCPSDAPSSGTVDPQLYQEILKTIQAEDIKKSFRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGYPSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFLVKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYFKAGLDVFKSVLDGKN
May be catalytically inactive.
Q58DX5
Q8NW49
THII_STAAW
tRNA 4-thiouridine synthase
Staphylococcus
MKYDHLLVRYGELTLKGSNRKKFVNQLRNNVNKSLKGLDGFVVKGKRDRMYIELEDHADINEITYRLSKIFGIKSISPVLKVEKTIEAMSAAAIKFAQQFEENSTFKIDVKRADKNFSMDTYELQRELGGAILKHFDNISVNVKRPDHEIRVEVRLDAIYMYEEVVPGSGGLPVGTGGKTLLMLSGGIDSPVAGMEVMRRGVTIEAIHFHSPPFTSDQAKEKVIELTRILAERVGPIKLHIVPFTELQKQVNKVVHPRYTMTSTRRMMMRVADKLVHQIGALAIVNGENLGQVASQTLHSMYAINNVTSTPVLRPLLTYDKEEIIIKSKEIGTFETSIQPFEDCCTIFTPKNPVTEPNFDKVVQYESVFDFEEMINRAVENIETLEITSDYKTIKEQQTNQLINDFL
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
Q8NW49
Q14I27
Y810_FRAT1
Nucleoid-associated protein FTF0810c
Francisella
MNFDMSKLMQQAQKMQEQMKKAQQERENMEVIGESGAGLVTVTMTGKYDVKSVSIDNSLMSEDKEILEDLIAAAVNSAVKKVEENSTASSDIYKMAKDAGIDLPSGINFPFK
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q14I27
Q5HPZ5
LSPA_STAEQ
Signal peptidase II
Staphylococcus
MKKKYYISISLLMTFIVLVFDQVSKWLITISMKVGDSYEIIPNFLNITSHRNNGAAWGILSGKMLFFYIITIIILIVLVIFYIKEAQFNLFMQVAISLLFAGALGNFIDRVLHGEVVDFIDTNIFGYDFPIFNIADSSLTIGVIFVIITLIKDAIINKKEV
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Q5HPZ5
Q4FLS2
SSRP_PELUB
Small protein B
Candidatus Pelagibacter
MNKKANPGLKIICLNRKASFNFFFEDLIEAGIVLKGSEIKSIRDGKVNIADSYAVEKDGEIVLINSHIAAFKQASYSNHNPTDERKLLLNKKEINKLIGKMQRDGFTLVPTKMYFKKGKAKIEIAVAKGKKQFDKRATKKNRDWNREKARHIRKSS
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
Q4FLS2
B2U233
DNAJ_SHIB3
Chaperone protein DnaJ
Shigella
MAKQDYYEILGVSKTAEEREIKKAYKRLAMKYHPDRNQGDKEAEAKFKEIKEAYEVLTDSQKRAAYDQYGHAAFEQGGMGGGGFGGGADFSDIFGDVFGDIFGGGRGRQRAARGADLRYNMELTLEEAVRGVTKEIRIPTLEECDVCHGSGAKPGTQPQTCPTCHGSGQVQMRQGFFAVQQTCPHCQGRGTLIKDPCNKCHGHGRVERSKTLSVKIPAGVDTGDRIRLAGEGEAGQHGAPAGDLYVQVQVKQHPIFEREGNNLYCEVPINFAMAALGGEIEVPTLDGRVKLKVPGETQTGKLFRMRGKGVKSVRGGAQGDLLCRVVVETPVGLNEKQKQLLQELQESFGGPTGEHNSPRSKSFFDGVKKFFDDLTR
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
B2U233
Q3M546
MTND_TRIV2
Acireductone dioxygenase (Ni(2+)-requiring)
Trichormus
MATLLLEDGTIESNLDEIARELAPLGVYIKHYDPGTSILFPHLLIQDALTDKEKCHIVDLHNSVFEFIQQENGYLWCDLLNVHPGSPNLQTLIATYAKYHTHTAPEALYVLAGEMIFGFVKPDGSQVQLLVQSQDYLHIPSGVEHWCSLTASLSFKAVRYFTAADGWVPNYTGTQLNDSLNK
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.
Q3M546
Q1J990
MNMG_STRPB
Glucose-inhibited division protein A
Streptococcus
MTHEFTESYDVIVIGAGHAGVEASLATSRMGCKTLLATINLDMLAFMPCNPSIGGSAKGIVVREIDALGGEMGKNIDKTYIQMKMLNTGKGPAVRALRAQADKSLYAREMKHTVEKQANLTLRQTMIDDILVEDGRVVGVLTATGQKFAAKAVVVTTGTALRGEIILGELKYSSGPNNSLASVTLADNLKKLGLEIGRFKTGTPPRVKASSINYDQTEIQPGDDKPNHFSFMSKDADYLKDQIPCWLTYTNQTSHDIINQNLYRAPMFSGIVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRDTEEVYVQGLSTSLPEDVQKDLIHSIKGLEKAEMMRTGYAIEYDIVLPHQLRATLETKLISGLFTAGQTNGTSGYEEAAGQGLIAGINAALKVQGKPELILKRSDAYIGVMIDDLVTKGTLEPYRLLTSRAEYRLILRHDNADMRLTEIGRDIGLVDDERWKAFEIKKNQFDNELKRLNSIKLKPVKATNDRVQELGFKPLTDAMTAKEFMRRPEIDYATAVSFVGPAAEDLDAKIIELLETEIKYEGYIRKALDQVAKMKRMEEKRIPANIDWDAIDSIATEARQKFKKINPETIGQASRISGVNPADISILMIYLEGNGKAHRKY
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q1J990
B2G7Q2
THIM_LIMRJ
4-methyl-5-beta-hydroxyethylthiazole kinase
Limosilactobacillus
MVQRQINWSLIDRVRAKNPIVLNLANLVTIDKVADAVSAVGASPIMSVEPAEADEMVMLANALSINLGTINEHQATQIRTVLRAATPLKPLVLDPVAVSAVPSRLKFAHSLLNDFHFDVIRGNASEIAALVEADNTSHGIDAGKVPNQVQIAETCARRYHSIVVLTGETDIITDGQVVYENPFSAEMLTMNVGSGDMLSSIIAAFLGITTNTWDACIVATVLVSAAGVLANRYSVGLGSWQVQFFDQLSIMDTKALLEFFDESEEDYLD
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
B2G7Q2
Q8ZVK6
AGOG_PYRAE
Pa-AGOG
Pyrobaculum
MAAESQLKRVIETLRRLGIEEVLKLERRDPQYRAVCNVVKRHGETVGSRLAMLNALISYRLTGKGEEHWEYFGKYFSQLEVIDLCRDFLKYIETSPFLKIGVEARKKRALKACDYVPNLEDLGLTLRQLSHIVGARREQKTLVFTIKILNYAYMCSRGVNRVLPFDIPIPVDYRVARLTWCAGLIDFPPEEALRRYEAVQKIWDAVARETGIPPLHLDTLLWLAGRAVLYGENLHGVPKEVIALFQWRGGCRPPSE
DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates.
Q8ZVK6
Q9KUX4
CYSJ_VIBCH
Sulfite reductase [NADPH] flavoprotein alpha-component
Vibrio
MNREVVTMSTGNTLPPALAALASPLNDAQLNQLQQTVTQLNAQQLAWVSGYFWGLSQSNALSVPHISAGQTASAASGKLTIIFASQTGNAKGVAQALLKEAQAAGIQAQLFDASDYKGKDLAKETHVIFVASTNGEGEAPDNALALHEFLKSKKAPKLPNLKYGVLGLGDSSYQFFCQTGKDFDQFLENLGAQRLVERLDADVDYQAAATEWRKQVLSILKDELTGAAAVTSVATFAVSQTAESHYSKEQPYTASLSTSQKITGRDSGKDVRHIEIDLADSGITYQPGDALGVWYENRPQLVNALLDSVGLSGHEEVQVDGETLSLHSALTHHYEITAANPQLVAQFAELAQSEKLTSLAQDKEALREYATRTQVIDVLREEKVTLSAIQLLSLLRRLTPRLYSIASSQSEVGEEVHLTVGVVEYEYEGEQRLGGASSFLAHQLEEGAPVKVFVEHNNNFKLPSDDNAPLIMVGPGTGIAPFRSFIQERENRGAAGKNWLLFGDRTFTQDFLYQVEWQKYLKSGVLNRLDVAFSRDQHEKVYVQHRLLEQAELVWQWLQEGAYFYVCGDASRMAKDVHQALITVVEQQGGLNREQAEEYVSELRKAKRYQRDVY
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
Q9KUX4
P68246
TNNI2_CHICK
Troponin I, fast-twitch isoform
Gallus
MSDEEKKRRAATARRQHLKSAMLQLAVTEIEKEAAAKEVEKQNYLAEHCPPLSLPGSMQELQELCKKLHAKIDSVDEERYDTEVKLQKTNKELEDLSQKLFDLRGKFKRPPLRRVRMSADAMLRALLGSKHKVNMDLRANLKQVKKEDTEKEKDLRDVGDWRKNIEEKSGMEGRKKMFEAGES
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
P68246
Q801R4
CTL2A_XENLA
CTD small phosphatase-like protein 2-A
Xenopus
MRLRMRKGSPRSSHVAAVRTARCKRKHSEEDEEEESPLIEEDKLPKQETGLLSTIKNFIKGSTNKEDRENPAKRSKVERDLDNNLITSTPRTGDKPSKPIARVRRKSQVNGEATAYEVSQHMKQNGKLEDLPCTTSPPRTTLLGTIFSPVFNFFSPANKNGTSGSDSPGQAVEAEEIVKQLDMEKVDEFSTSTATNGASYPSLGAPVRSTAGSWLEGTEDTPERDIPPLTAPVSPESGYSSAHAEAAYEEDWEVFDPYFFIKHVPPLTEEQLNRKPALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQIYEIILFTASKKVYADKLLNILDPKKRLVRHRLFREHCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDKELLKLVPFLENLVELNEDVRPHVRDRFRLHDCLPPD
Probable phosphatase.
Q801R4
B9V973
MCP1A_MACPC
Macrocypin-1a
Macrolepiota
MGFEDGFYTILHLAEGQHPNSKIPGGMYASSKDGKDVPVTAEPLGPQSKIRWWIARDPQAGDDMYTITEFRIDNSIPGQWSRSPVETEVPVYLYDRIKAEETGYTCAWRIQPADHGADGVYHIVGNVRIGSTDWADLREEYGEPQVYMKPVPVIPNVYIPRWFILGYEE
Inhibits papain and cysteine cathepsin endopeptidases, and also inhibits cathepsins B and H, which exhibit both exopeptidase and endopeptidase activities.
B9V973
Q8SPU5
BPIA1_BOVIN
Palate lung and nasal epithelium clone protein
Bos
MFHIGSLVVLCGLLAPTTALLEALPTPLGQTLPLAVTPALAPSPPDLAGSLTGALSNGLLSEGLLGILENLPLLDILKTRGNAPSGLLGSLLGKVTSLTPLLNNIIELKITNPQLLELGLVQSPDGHRLYVTIPLGMILNVKTSLVGSLLKLAVKLNITVELLAVTDEQKHVHLVVGNCTHSPGSLQIFLLDGLGSLPIQSFVDNLTGILNDVLPGLVQGKVCPLVNAVLSRLDVTLVHSIVNALIHGLQFVIKV
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils.
Q8SPU5
Q5AB49
Y6200_CANAL
Probable pathogenesis-related protein CaO19.6200
Candida
MKFLQSFPVILAVFSFAANLVSSKLVYEYETKYVTVEIVTIVSGETTYTTERLETNGPTSTTTTIVIPSSKPSSPESKPKSDSQPMFQSPSPVQITPSTTSINNAPSPTKPETTVTASPAVIAHTSVFVVTPNSAPTTSSSPPNIVQQVKAAITPSAPKPQPQPQPQENNSGTNDDSQLSSFSRQILEAHNIKRASHGVNPLTWSNELYNYANKVASSYDCSGNLRHTSGPYGENLALGYSSGANAVSAWYSEGFNFGGAGKLNHFTQVVWKSTTQLGCAYKDCRAKGWGLYIICNYQKPGNIIGQELANILPLIRS
Secreted protein that acts as a virulence factor during infections.
Q5AB49
Q7F8T6
OMT17_ORYSJ
Caffeoyl-CoA 3-O-methyltransferase ROMT17
Oryza sativa
MSMACTKVWRSTMYTPRRLKRTTPASRVSSTAMAAANGDASHGANGGIQIQSKEMKTAIHSNDSPKTLLKSESLHEYMLNTMVYPRENEFMRELRLITSEHTYGFMSSPPEEGQLLSLLLNLTGAKNTIEVGVFTGCSVLATALAIPDDGKVVAIDVSREYFDLGLPVIKKAGVAHKVDFREGAAMPILDNLLANEENEGKFDFAFVDADKGNYGEYHERLLRLVRAGGVLAYDNTLWGGSVALEDDSVLEEFDQDIRRSIVAFNAKIAGDPRVEAVQLPVSDGITLCRRLV
Catalyzes the stepwise methylation of tricetin to its 3'-mono- and 3',5'-dimethyl ethers. No 3',4',5'-trimethylated ester derivatives are produced. Can use caffeoyl CoA, 5-hydroxyferulic acid, luteolin, tricetin, quercetin, myrcetin and 7,8-dihydroxyflavone as substrates, but not naringenin, apigenin or kaempferol. The 2,3-double bond and the O-dihydroxyl group of the substrate are both required for catalytic activity of the enzyme.
Q7F8T6
P0C916
RBL1A_ACIFR
Ribulose bisphosphate carboxylase large chain 1
Acidithiobacillus
MAVKTYEAGVKDYRQTYWAPEYVPLDSDILACFKITPQPGVDREEAAAAVAAESSTGTWTTVWTDLLTDMDYYKGRAYRIEDVPGDDTCFYAFVAYPIDLFEEGSVVNVFTSLVGNVFGFKAVRALRLEDVRFPLAYVKTCNGPPHGIQVERDKMNKYGRPMLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFIAWRDRFLFVADAIHTAEAETGERKGHYLNVTAPSPEEMYERAEFAKELNMPIIMHDFLTGGFCANTGLARWCRKNGVLLHIHRAMHAVVDRNPHHGIHFRVLAKALRLSGGDHLHTGTVVGKLEGDRAATQGWVDLLRESFVPEDAGRGIFFDQDWGSMPGVFAVASGGIHVWHMPALLAIFGDDAIFQFGGGTLGHPWGNAAGAAANRVALEACVEARNEGRDLEREGKDILTNAAKDSPELKIALETWKEIKFEFDTVDKLDVVNR
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
P0C916
Q9ZVT7
RRP4_ARATH
Ribosomal RNA-processing protein 4
Arabidopsis
MVMRKLQLPLSQTQKVRFERAIERLQSLSSSANSDASVIVTDSIPVNHDDAFLKGHGTSEVDGELLATVCGVVERVDKLVYVRTLRARYKPEVGDIVVGRVIEVAQKRWRVELNFNQDGVLMLSSMNMPDGIQRRRTSVDELNMRNIFVEHDVVCAEVRNFQHDGSLQLQARSQKYGKLEKGQLLKVDPYLVKRSKHHFHYVESLGIDLIIGCNGFIWVGEHVEVRDPMAIDDQKDEEMISSSSTGKEQSHIPLETRQTICRIGNAIRVLSNLGFTVTLEVIMETVNLSNSKNIDIHDMLGSEFHVVVAENEAERRRTKRKK
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing, maturation and degradation events. In vitro, is an active and distributive 3'->5' exonuclease requiring a free 3'-OH on the substrate and releasing nucleoside 5'-monophosphates . Required for normal embryo development .
Q9ZVT7
A1QZN3
SYDND_BORT9
Non-discriminating aspartyl-tRNA synthetase
Borrelia
MFKTIKCNQINDKLINQKIEINAWVKKIRHHGKVTFINLRDRYDEAQVLVNDEKLLKITSQIKMEYCIKVQGKLELRPSNLVNKEMRTGAFEILAENINIISRCNELPFMIEDNNNANENAKLEYRYLDLRREEQKQKIILRSKVTHTIRNYLTKKDFLELETPTFVKSTPEGARDFLVPSRIHKGHFYALPQSPQIYKQLTMIAGLDKYFQIARCYRDEDSRGDRQPEFTQLDIEMSFIKKENIFKLMENLIFTIFKNTLNISLPKKFKRMTYKHAMNTYGSDKPDTRYELLIQDMGKYFKQSSFNVFKDILQNKGTIKALIIKNQAHNFSRSKINNLEEHAKIYKTSGLYFAKIENNEFVGGIAKFLNKIKQTLFQTYSLKNNDIIFFIADSWETACKAMGQIRIKIANELNLTNKNTFEFLWIYDFPLFEYDEDTKNYKAAHHMFSLPQQKYIDTLESNPSKVLGEVYDLVLNGMELGSGSIRVHTRELQQRIFNIVGFKDTIAEERFGFFLKALEYGAPIHGGIAIGIDRLLMIMTHSSSIKDVILFPKNSFAASPLDKAPSKVPNEQLRELNLTIEDYKN
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
A1QZN3
Q12TB6
TUSA_SHEDO
Sulfur carrier protein TusA
Shewanella
MTDVFSQAQHQLDALGLRCPEPVMMVRKTVRKMADGETLLIIADDPATTRDIPSFCEFMDHTLIASDTSKTPYQYLLKKGR
Sulfur carrier protein which probably makes part of a sulfur-relay system.
Q12TB6
Q9X4Q2
METK_STRST
Methionine adenosyltransferase
Streptomyces
MSRRLFTSESVTEGHPDKIADQISDTILDALLREDPTSRVAVETLITTGLVHVAGEVTTKAYAPIAQLVREKILEIGYDSSKKGFDGASCGVSVSIGAQSPDIAQGVDTAYESRVEGDEDELDRQGAGDQGLMFGYACDETPELMPLPIHLAHRLSRRLSEVRKNGTIPYLRPDGKTQVTIEYDGDKAVRLDTVVVSSQHASDIDLESLLAPDIREFVVEPELKALVEDGIKLETEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMSRHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLASRCEVQVAYAIGKAEPVGLFVETFGTNTIDTDKIEQAISEVFDLRPAAIIRDLDLLRPIYSQTAAYGHFGRSLPEFTWEKTDRVDGCGRPPVWRADLLPLVH
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
Q9X4Q2
O74448
PIN1_SCHPO
Peptidyl-prolyl cis-trans isomerase pin1
Schizosaccharomyces
MSNTGLPKPWIVKISRSRNRPYFFNTETHESLWEPPAATDMAALKKFIANELQESVTPTEASNSPKIRASHLLVKHRESRRPSSWKEEHITRSKEEARKLAEHYEQLLKSGSVSMHDLAMKESDCSSARRGGELGEFGRDEMQKPFEDAAFALKPGEISGVVETSSGFHIIQRHA
Has a role in the G1/S stage transition of mitosis where it is involved in the dephosphorylation of cdc25 and wee1.
O74448
Q00604
NDP_HUMAN
X-linked exudative vitreoretinopathy 2 protein
Homo
MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS
Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Q00604
Q11HL3
LFTR_CHESB
Phenyalanyltransferase
unclassified Chelativorans
MTRPLAPGFHIPPDLLLRAYATGVFPMAEHADDPEVFWVRPEMRGIIPLDKFHVPKSLRKLLRRQPYEVRYDTDFTGVIDACAEPSAERAETWINEPIRVAYTELFKRGHCHTVEAWREGKLVGGLYGVSLGRAFFGESMFSREPNASKICLVHLVERLKAGGFLLLDTQFTTDHLRRFGAIDVPRRRYEQMLAEALEETAKF
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
Q11HL3
Q15YN6
RL2_PSEA6
50S ribosomal protein L2
Pseudoalteromonas
MPLLKAKPTSAGRRHVVQVVNPDLHKGAPYAPLLEKNSKSGGRNNNGRITVRHVGGGHKQHYRVIDFKRNKDGIPAKIERLEYDPNRSANICLVLYADGERRYILAPKGAKAGDQIQSGSDAAIKAGNSLPMRNIPVGTTVHAIEMKPGKGAQIARSAGQYAQILARAEGYVTLRLRSGEVRRVLADCRATIGEIGNAEHMLRSLGKAGANRWRGIRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVSPWGVPTKGKKTRSNKRTDKLIVRRRNK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Q15YN6
Q7V6I0
PSBD_PROMM
Photosystem Q(A) protein
Prochlorococcus
MTIAVGRAPQRGWFDVLDDWLKRDRFVFVGWSGLLLFPTAYLALGGWFTGTTFVTSWYTHGIASSYLEGCNFLSAAVSTPADAMGHSLLLLWGPEAQGDFVRWCQLGGLWTFVALHGSFSLIGFMLRQFEIARLVGIRPYNALAFSGPVVVFLACFLIYPLGQHSWFFAPSFGVAAIFRFILFLQGFHNWTLNPFHMMGVAGILGGALLCGIHGATVQNTLFEDGAMSNTFKGFDPTQEEETYSMVTANRFWSQIFGIAFSNKRWLHFFMLFVPVMGMWTPSVGIVGLAVNLRAYDFVSQEVRAAEDPEFETFYTKNVLLNEGIRAWMSVADQPHENFVFPEEVMPRGNAL
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors. D2 is needed for assembly of a stable PSII complex.
Q7V6I0
P51984
CREB_HYDVD
cAMP response element-binding protein
Hydra
MELARHSFQQPLNVAPSLSNVVNKTSVVLQQQSVIQPNQHQLQHQLQTMHDGGIDGKRREILARRPSYRRILDDLAGDGPVKMENYDDTGSSGESSPNGNNEEDINGINQSVSHQEKQYQSIHLNGIVSSVQGGENSLNQLHDSQPGDNQYIITTQGPDNKIQAYTIKGTLPIGLDNTSLASPHQLAEEATRKRELRLYKNREAARECRRKKKEYVKCLENRVAVLENQNKALIEELKSLKDLYCSKGD
This protein binds the cAMP response element (CRE), sequence present in many viral and cellular promoters. Could regulate the transcriptional activity of genes involved in regeneration processes.
P51984
Q8FDH4
GLNE_ECOL6
Adenylyl transferase
Escherichia
MKPLSSPLQQYWQTVVERLPEPLAEESLSAQAKSVLTFSDFVQDSVIAHPEWLTELESQPPQADEWQHYASWLQEALSNVSDEAGLMRELRLFRRRIMVRIAWAQTLALVTEESILQQLSHLAETLIVAARDWLYDACCREWGTPCNAQGEAQPLLILGMGKLGGGELNFSSDIDLIFAWPEHGCTQGGRRELDNAQFFTRMGQRLIKVLDQPTQDGFVYRVDMRLRPFGESGPLVLSFAALEDYYQEQGRDWERYAMVKARIMGDSDGVYANELRAMLRPFVFRRYIDFSVIQSLRNMKGMIAREVRRRGLTDNIKLGAGGIREIEFIVQVFQLIRGGREPSLQSRALLPTLSAIAALHLLSENDAEQLRVAYLFLRRLENLLQSINDEQTQTLPFDELNRARLAWAMDFADWPQLTGVLTAHMANVRRVFNELIGDDESETQEESLSEQWRELWQDALQEDDTTPVLAHLSEDDRKQVLMLIADFRKELDKRTIGPRGRQVLDHLMPHLLSDVCAREDAAVTLSRITALLVGIVTRTTYLELLSEFPAALKHLISLCAASPMIASQLARYPLLLDELLDPNTLYQPTATDAYRDELRQYLLRVPEDDEEQQLEALRQFKQAQLLRIAAADIAGTLPVMKVSDHLTWLAEAMIDAVVQQAWVQMVARYGKPNHLNEREGRGFAVVGYGKLGGWELGYSSDLDLIFLHDCPMDAMTDGEREIDGRQFYLRLAQRIMHLFSTRTSSGILYEVDARLRPSGAAGMLVTSAEAFADYQKNEAWTWEHQALVRARVVYGDPQLTAHFDAVRREIMTLPREGKTLQTEVREMREKMRAHLGNKHRDRFDIKADEGGITDIEFITQYLVLRYAHEKPKLTRWSDNVRILELLAQNDIMEEQEAMALTRAYTTLRDELHHLALQELPGHVSEDCFTAERELVRASWQKWLVEE
Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.
Q8FDH4
Q20303
ELO6_CAEEL
Monomethyl branched-chain fatty acid elongase 6
Caenorhabditis
MPQGEVSFFEVLTTAPFSHELSKKHIAQTQYAAFWISMAYVVVIFGLKAVMTNRKPFDLTGPLNLWNAGLAIFSTLGSLATTFGLLHEFFSRGFFESYIHIGDFYNGLSGMFTWLFVLSKVAEFGDTLFIILRKKPLMFLHWYHHVLTMNYAFMSFEANLGFNTWITWMNFSVHSIMYGYYMLRSFGVKVPAWIAKNITTMQILQFVITHFILFHVGYLAVTGQSVDSTPGYYWFCLLMEISYVVLFGNFYYQSYIKGGGKKFNAEKKTEKKIE
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. Uses malonyl-CoA to add 2 carbons per cycle to the chain of long-chain fatty acids. Condensing enzyme required for the formation of isoheptadecanoate (C17iso), which plays critical roles in animal development and growth.
Q20303
Q9BZI7
REN3B_HUMAN
Up-frameshift suppressor 3 homolog on chromosome X
Homo
MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPPTLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFLDNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEGGEE
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
Q9BZI7
A1ALL5
ATPA_PELPD
F-ATPase subunit alpha
Pelobacter
MKIRAEEISEIIKKQIREYGKEVEVSETGTIISIGDGIARIHGLSGAMAGELLEFPGGVSGMVLNLEEDNVGAAVLGEFTAIKEGHTVKRTGRIAEVPVGEALIGRVVNAIGEPIDGKGPIKTDTFSKVEIKAPGIVARKSVDQPMASGLKAVDAMVPIGRGQRELIIGDRQTGKTAVAVDTIINQKGGDVICIYVAIGQKRSTVAQVVAKLSDHGAMDYTIVVAASASESAPLQFIAPYSGVTMGEYFRDKGQHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERACKLSDECGGGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLESDLFFSGVRPAINVGLSVSRVGGKAQTKSMKQVAGTLRLNLAQYREMAAFAQFGSDLDKATQMQLARGERLVEILKQPQYRPLSNEKQVLIIFAANNGFLDELPVSTLRRYEDEMYAFFDNRQADLLSELRDKKAIDDELKKRIVAALEQFKKEFSA
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
A1ALL5
Q5F605
PYRD_NEIG1
Dihydroorotate oxidase
Neisseria
MYPLARRILFALDAEKAHHFTLDALNTVYKLGLIPVTDNRTKPIKLMGMDLPNPVGLAAGLDKNGEYIDALGALGFGFLEIGTVTRNPQPGNPQPRLFRVPEHQGIINRMGFNNHGIDAMIRNIEKSKYQGVLGINIGKNAVTPIQNAADDYLICLEKAYAHASYITVNISSPNTKNLRALQGGGELGALLEALKNKQAQLAAAHGKYIPLAVKIAPDLDEAQIEDIARVVKSVEMDGIIATNTTIDKSSLGSHPLAGEQGGLSGFPVREKSNRVLKKLAEHIDGALPIIGVGGIMEGGDAAEKIRLGTTAVQVYSGLIYKGPALVKECLKALAR
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Q5F605
D4GTK4
SECF_HALVD
Protein-export membrane protein SecF
Haloferax
MVEFTVPEVDYTRYTNRQLAAVPLAVLAVALLVIGGWYVATGAPVNPGVDFTGGTELRIATDAPQSEVAAAFDSQPESIRSVAADGTYVVTFQSGSATSTELQTQAEDAGFEVRSIDAVSANFGGETQLLALGGLAVAFAGMSVLVFAMFRSFVPSIAVVLSAFSDIVIPVALMNLFGIELSLGTVAALLMLIGYSVDSDILLNNHVLRRSGDFYESTARAMRTGVTMTLTSIAAMIVMTIMATLFGIQLLAAIGTVLVFGLTADLMNTYMLNVTLLRWYKFEGVTR
Involved in protein export.
D4GTK4
B2IH44
CTAA_BEII9
Cytochrome aa3-controlling protein
Beijerinckia
MSALDTAPAGSLAETHAQRGTRAVAFWLWSLAVLVFLMVVLGGATRLTESGLSITEWKPISGALPPLSAEAWQAEFENYKRIPQYAALFPDMDLAGFKFIFFFEWSHRLLGRLIGVATALPLLFFWLRGRLPEGYRLKLLGLLALGGLQGFVGWWMVKSGLSDRVEVAQERLAIHLILASLTFCFIVWLAASLRKRPREISPSKASGLAWGAGLILLAILVQIGLGALVAGLRAGRAYNTWPLIEGNFLPPVESLTLLTPLWRNFVDNLLTVQFQHRMVAYLVLGLTLLQVFWTSGTLGSGRATKRAIALLGLVLAQVILGILTLVLVVPLWAGLLHQAFAMLVLGMAVAHLQALSQGR
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
B2IH44
B7NSJ1
NORW_ECO7I
Flavorubredoxin reductase
Escherichia
MSNSIVIIGSGFAARQLVKNIRKQDASIPLTLIAADSMDEYNKPDLSHVISQGQRADDLTRQTAGEFAEQFNLRLFPHTWVTDIDAEAHVVKSQNNQWQYDKLVLATGASAFVPPVPGRELMLTLNSQQEYRACETQLRDARRVLIVGGGLIGIELAMDFCRAGKAVTLIDNAASILASLMLPEVSSRLQHRLTEMGVHLLLKSQLQGLEKTDSGILATLDRQRSIEVDAVIAATGLRPETALARRAGLTINRGVCVDSYLQTSNADIYALGDCAEINGQVLPFLQPIQLSAMVLAKNLLGNNTPLKLPAMLVKIKTPELPLHLAGETQRQDLRWQINTERQGMVARGVDDGDQLRAFVVSEDRMKEAFGLLKTLPM
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
B7NSJ1
A4R5F6
ARGJ_MAGO7
Arginine biosynthesis bifunctional protein ArgJ beta chain
Pyricularia
MASKSTSTAVWGQLRHLAQQQTRCYSATADSIPASKKKYVPTKGVYPKGFRVSGTIVGVKPGNTTKPDLAFVTSDTPCAAAAVFTKNRFQAAPVTFSRDLLKKKGNSGVNGVIINSGCANAVTGKGGLEDAESMAREADRCLGGDGTIVMSTGVIGQRLPIKRILDNVPAAHSRLGSSHDHWLSCATAICTTDTFPKLMSRSFTLPSSPSVEYRIAGMTKGAGMIHPNMATLLGVIATDAPIAPAVLPSLLKNAVDRSFNSITIDGDTSTNDTVALLANGAAGGKEIASESSPDFAAFRDVLNVFSEDLAKLIVRDGEGATKFVTIRVVESDSEETAKKVASTIARSPLVKTALYGKDANWGRILCATGYALISEPGSAAVAEVSDKIVPEKTNVSFVPTDGTAELKLLVDGEPEQVDEVRAAEILKAEDLEILVRLGTGKAEGTYWTCDFSHEYVTINGDYRT
Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.
A4R5F6
P04712
SUS1_MAIZE
Sucrose-UDP glucosyltransferase 1
Zea
MAAKLTRLHSLRERLGATFSSHPNELIALFSRYVHQGKGMLQRHQLLAEFDALFDSDKEKYAPFEDILRAAQEAIVLPPWVALAIRPRPGVWDYIRVNVSELAVEELSVSEYLAFKEQLVDGQSNSNFVLELDFEPFNASFPRPSMSKSIGNGVQFLNRHLSSKLFQDKESLYPLLNFLKAHNYKGTTMMLNDRIQSLRGLQSSLRKAEEYLLSVPQDTPYSEFNHRFQELGLEKGWGDTAKRVLDTLHLLLDLLEAPDPANLEKFLGTIPMMFNVVILSPHGYFAQSNVLGYPDTGGQVVYILDQVRALENEMLLRIKQQGLDITPKILIVTRLLPDAAGTTCGQRLEKVIGTEHTDIIRVPFRNENGILRKWISRFDVWPYLETYTEDVSSEIMKEMQAKPDLIIGNYSDGNLVATLLAHKLGVTQCTIAHALEKTKYPNSDIYLDKFDSQYHFSCQFTADLIAMNHTDFIITSTFQEIAGSKDTVGQYESHIAFTLPGLYRVVHGIDVFDPKFNIVSPGADMSVYYPYTETDKRLTAFHPEIEELIYSDVENSEHKFVLKDKKKPIIFSMARLDRVKNMTGLVEMYGKNARLRELANLVIVAGDHGKESKDREEQAEFKKMYSLIDEYKLKGHIRWISAQMNRVRNGELYRYICDTKGAFVQPAFYEAFGLTVIESMTCGLPTIATCHGGPAEIIVDGVSGLHIDPYHSDKAADILVNFFDKCKADPSYWDEISQGGLQRIYEKYTWKLYSERLMTLTGVYGFWKYVSNLERRETRRYIEMFYALKYRSLASQVPLSFD
Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways. Most active in the sink tissues where it is responsible for the breakdown of the arriving sucrose.
P04712
Q8J1Z1
TIM9_NEUCR
Mitochondrial import inner membrane translocase subunit tim9
Neurospora
MDGLTAAESRELDQRLQKRQVKEFMSVFGNLVDNCFTACVDDFTSKALSGRESGCISRCVLKSMSTQTRLGERFGELNAAMTAEMQRR
Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.
Q8J1Z1
Q87YR0
FOLD1_PSESM
Methenyltetrahydrofolate cyclohydrolase
Pseudomonas
MTAKLIDGKAIAASLRQQIAKRVAERSQQGLRTPGLAVILVGSDPASQVYVSHKRKDCEEVGFISQAYDLPAETTQVALTNLIDRLNEDAAVDGILLQLPLPAHLDASLLLERIRPDKDVDGFHPYNVGRLAQRIPLLRPCTPKGIIALLESTGVDLYGLDAVVVGASNIVGRPMAMELLLAGCTVTVTHRFTKDLAGHVSRADLVVVAAGKPGLVKGEWIKPGAIVIDVGINRQDDGKLVGDVVYETALPRAGWITPVPGGVGPMTRACLLENTLYAAETLHD
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q87YR0
O30394
TYSY_BACAT
Thymidylate synthase A
Bacillus
SEVPILTTKKLAWKTAIKELLWIWQLKSNDVNDLNKMSVHIWDQWKQEDGTIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVRV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
O30394
O95196
CSPG5_HUMAN
Neuroglycan C
Homo
MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQNSMSPKLEGGKGDQADLDVNCLQNNLT
May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation.
O95196
B5XNE5
MSRQ_KLEP3
Flavocytochrome MsrQ
Klebsiella
MRFTVKQIAWLKVFLHLAGFLPLVWLFWAGHQGYFSADPAKDIQHFTGRMALKFLLATLLVAPLARYAKQPLLIRIRRLLGLWCFAWATLHLTSYTLLELGINNLALLGSEIINRPYLTLGMICWVILLALAATSTQAMQRKLGRRWQLLHNFVYLVAILAPIHYLWSVKIVSPQPIIYALLAVVLLACRYKKFRQWWR
Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain.
B5XNE5
Q2LR03
GREA_SYNAS
Transcript cleavage factor GreA
Syntrophus
MEKMPITKSGFENLKKELEHLKCVLIPANIKDIEIARAHGDLSENAEYTAAKEKQSFLHGKLQELENNLALSNVIDLKMLSDDRIVFGATVIIEEASTGKQTNYQLVGPFESNISENKISVTSPIGKALIGKSIGDEVKVHTPGGIRNFEVVDIYINPSEL
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Q2LR03
Q84TG3
PUB23_ARATH
U-box domain-containing protein 23
Arabidopsis
MSGGIMDEEIEIPPFFLCPISLEIMKDPVIVSTGITYDRDSIEKWLFAGKKNSCPVTKQDITDADLTPNHTLRRLIQSWCTLNASYGVERIPTPRPPICKSEIEKLIRDSASSHENQVKCLKRLRQIVSENATNKRCLEAAGVPEFLANIVSNDSENGSLTDEALNLLYHLETSETVLKNLLNNKKDNNIVKSLTKIMQRGMYESRVYATLLLKNILEVADPMQSMTLKPEVFTEVVQILDDRISQKATKAAMHILVNICPWGRNRHKAVEAGVISVIIELLMDESFTSERRGPEMAMVVLDLLCQCAEGRAEFLNHGAAIAVVCKKILRVSQTASDRAVRVLLSVGRFCATPALLHEMLQLGVVAKLCLVLQVSCGGKTKEKAKELLKLHARVWKDSPCLPKNMILAYPC
E3 ubiquitin-protein ligase that negatively regulates water stress response. May control in coordination with PUB23 a drought signaling pathway by ubiquitinating cytosolic RPN12a. Acts as negative regulator of the immunity triggered by the pathogen-associated molecular patterns (PAMPs), in association with PUB22 and PUB24.
Q84TG3
Q7M8E4
RL24_WOLSU
50S ribosomal protein L24
Wolinella
MVKFQIKKGDKVQVIAGDDKGKVAEVIKVMPKSSQVIVAGCKVAKKSVKPSEQNPKGGFVNKEMPIHISNVKKVEA
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Q7M8E4
Q0I5I2
FTSB_HAES1
Cell division protein FtsB
Histophilus
MRLFILSLFALLVMFQYDFWFGKNGYLDYQDIKAEIIQRKQENKKLSQRNQTIFAEIQDLKNGIEAIEERARMEHEMIKQNEVFYRIVKNKNR
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
Q0I5I2
Q7TPS5
C2CD5_MOUSE
138 kDa C2 domain-containing phosphoprotein
Mus
MPGKLKVKIVAGRHLPVMDRASDLTDAFVEVKFGNTTFKTDVYLKSLNPQWNSEWFKFEVDDEDLQDEPLQITVLDHDTYSANDAIGKVYIDIDPLLYSEAATVISGWFPIYDTIHGIRGEINVVVKVDLFNDSNRFRQSSCGVKFFCTTSIPKCYRAVVIHGFVEELVVNEDPEYQWIDRIRTPRASNEARQRLISLMSGELQRKIGLKVLEMRGNAVVGYLQCFDLEGESGLVVRAIGTACTLDKLSSPAAFLPACSSPSRELKEIPFNEDPNPNTHSSGPSTPLKNQTYSFSPSKSYSRQSSSSDTDLSLTPKTGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFLTLTAFPPGLLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQEGTVEGCLEQRIEENLPVGCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDAVVVGKGCLIQARLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGETMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKRINDTIAKNKELYEITPPEVSEEMIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDAPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVVRLSSLNLTNQALNKNFNGLCENLLKSLYFKLRSMTPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKPHVEKSLQRASTDNEELLQFPLELCSDSLPPHPFPAAKEHLESANSNSGIPAAQRAVTVEKASAMGDGNFRNRSAPPCASPTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPSKNQAQCLINVSGDAVVFVRDSDLEVMSSQQPAANCQPSCTGEVTT
Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM.
Q7TPS5
Q91ZB5
MRGRG_MOUSE
Evolutionary breakpoint transcript 2 protein
Mus
MFSIFNIWGTFNKVLFFLSLTVSLAGLVGNALLLWHLGLHIKKGPFNTYLLHLAAADFLFLSCQVGFSIATIVSGHEDTLYFPVTFLWFAVGLWLLAAFSVDCCLAYMFPSFCSPNRRPRFTSVVLCLVIWALTMPAVLLPANACGLLKNGMSLLVCLKYHWTSVTWLAVLSGMACGASKFLLIFGNCCSSQPPPKFCKLAQCSGILLFFCRLPLVVYWCLRPVLKFLLPFFFPLATLLACIDSSAKPLLYYMKGRQLRKDPLQVALNRALGEESQSGLGGLSLPMHQV
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Q91ZB5
B8EAU2
THII_SHEB2
tRNA 4-thiouridine synthase
Shewanella
MKFIVKLYPEIMMKSKPVRMRFTKMLETNIRNVLKKVDEDAKVQRQWDRIMVMVPKDKPELAQAFGERLACIPGIAHVVQVDEYSFESVDDIYQQVLPVYRDQLAGKTFCVRVKRTGDHDFNSIEVERYVGGGLNQFTDALGVRLKNPDITVNLEIERDNLYMVTKRIEGLGGFPMATQEDVLSLISGGFDSGVSSYQFIKKGARTHYCFFNLGGAQHEIGVKQVAYHLWKTYGESHKVKFISVPFEPVVAEILERIDNGQMGVVLKRMMMRTAARIADRMGIQALVTGESLGQVSSQTLTNLNVIDRCTELLILRPLIAMDKQDIINESRKIGTEDFAKSMPEYCGVISQKPTVKAVLAKVEAEEKKFSEDLIDQIIAQSVTIDIREIAEQMDTRITETETVASIDTNQVVIDIRAPEEEESKPLQIEGIEIKRIPFFKLATQFADLDKQKTYLLYCERGVMSKLQALYLIEQGYTNVKVYRP
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
B8EAU2
Q1D7Z0
ENGB_MYXXD
Probable GTP-binding protein EngB
Myxococcus
MIKVLDARFVTTAVEPKGYPTDHTAEVAFVGRSNVGKSSMINALTGRRKLVRVSNTPGRTRTLNFFDVDLERGGVRHQIRLADLPGYGFAKASKADKAQWEKMITTYLEKRHRLEAVVSIVDVEVGPTPDDLTTLDYLQAHNRRVLVVATKVDRLTKARLKPRLVELSKLMDLPLEVILPFSSTEKLGVDEVWGALLDTFGKSARV
Necessary for normal cell division and for the maintenance of normal septation.
Q1D7Z0
Q5HJ89
ESSA_STAAC
ESAT-6 secretion machinery protein EssA
Staphylococcus
MLMNSVIALTFLTASSNNGGLNIDVQQEEEKRINNDLNQYDTTLFNKDSKAVNDAIAKQKKERQQQIKNDMFQNQASHSTRLNETKKVLFSKSNLEKTSESDKSPYIQNKQEKKIFPYILMSVGAFLTLGFVIFSIHKGRRTKNESARKSNI
Component of the ESAT-6 secretion system (Ess). Required for the secretion of EsxA and EsxB.
Q5HJ89
Q8U9L5
PAL_AGRFC
Outer membrane lipoprotein Omp16 homolog
Agrobacterium tumefaciens complex
MSRTNISALSPMQKLARNPAVIAMTLALALAGCANKKNMPNSAGELGLGGAGSATPGSQQDFTVNVGDRIFFDTDSTSIRADAQQTLQRQAQWLSRYPNYAITVEGHADERGTREYNLALGARRAAATRDFLASQGVPASRMKTISYGKEKPVAVCDDISCWSQNRRAVTVLGGAGM
Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.
Q8U9L5
Q9N2D1
TRYT_PIG
Tryptase
Sus
MLNLLVLALPLLVSLVHTAPAPGQALERAGIVGGKEAPGHKWPWQVSLRCLDQYWKHFCGGSLIHPQWVLTAAHCFGPEKADPLYIRVQLGEQHLYYQDRLLLVSRIIVHPNYYDEVNGADIALLELEDPVNLSSHVQPVTLPPASETFPKGTRCWVTGWGDVHSGWPLPPPYPLKQVRVPIVENSECDMQYHLGLSTGDNIPIVRDDMLCAGSEGHDSCQGDSGGPLVCRVNGTWLQAGVVSWGEGCALPNRPGIYTRVTHYLDWIHQCIPRES
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type.
Q9N2D1
Q53LQ0
PDI11_ORYSJ
Endosperm storage protein 2
Oryza sativa
MAISKAWISLLLALAVVLSAPAARAEEAAAAEEGGDAAAEAVLTLDADGFDEAVAKHPFMVVEFYAPWCGHCKKLAPEYEKAAQELSKHDPPIVLAKVDANDEKNKPLATKYEIQGFPTLKIFRNQGKNIQEYKGPREAEGIVEYLKKQVGPASKEIKSPEDATNLIDDKKIYIVGIFSELSGTEYTNFIEVAEKLRSDYDFGHTLHANHLPRGDAAVERPLVRLFKPFDELVVDSKDFDVTALEKFIDASSTPKVVTFDKNPDNHPYLLKFFQSSAAKAMLFLNFSTGPFESFKSVYYGAAEEFKDKEIKFLIGDIEASQGAFQYFGLREDQVPLIIIQDGESKKFLKAHVEPDQIVSWLKEYFDGKLSPFRKSEPIPEVNDEPVKVVVADNVHDFVFKSGKNVLVEFYAPWCGHCKKLAPILDEAATTLKSDKDVVIAKMDATANDVPSEFDVQGYPTLYFVTPSGKMVPYESGRTADEIVDFIKKNKETAGQAKEKAESAPAEPLKDEL
Probable protein disulfide isomerase that plays an essential role in the segregation of proglutelin and prolamin polypeptides within the ER lumen of endosperm. Required to retain proglutelin in the cisternal ER lumen until ER export and, thereby, indirectly prevents heterotypic interactions with prolamin polypeptides.
Q53LQ0
P24711
INVO_CEPBA
Involucrin
Cephalopachus
MSQQQTLPVTLPPALSQELLKTVPPPANTQQDQMKQPTPSPAPCQKGPSELPVEKHPAPVKQVPEQECEPQQQDHQEPELQLGRKQQEPQEQEVHPGKQQQKPQEQEAHLGKKQEPQGQEVHLGKQQQKTQEQEVHLGKQQQELQEQEVHLEKQLQEPQEVHLEKQLQEQEVHLEKQLQEPEPELNLGKQQQEPQEQEAYLGKQQQELPEPQDPELHLGKQQQEPQEQEVQLEKQQEAQEQELHLGKQQQESQEQELHLRKLQQVPQEPQDQELHLGKQQQELQEQEVHLGKQLQEPQEQELHLGRQQQELQEEEVHLGMKEEQLLKHVEQQEGQLEQQEGQLKQPVCIPTPGQVQDIQPAQPPKGEVLLPTEKQQKQEVQWPLKQE
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
P24711
P0DPK3
NT2NB_HUMAN
Notch homolog 2 N-terminal-like protein B
Homo
MPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGICLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway . Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production . Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect . Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 . Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation .
P0DPK3
A7ZSB6
NANE_ECO24
ManNAc-6-P epimerase
Escherichia
MSLLAQLDQKIAANGGLIVSCQPVPDSPLDKPEIVAAMALAAEQAGAVAIRIEGVANQQATRAVVSVPIIGIVKRDLEDSPVRITAYIEDVDALAQAGADIIAIDGTDRPRPVPVETLLARIHHHGLLAMTDCSTPEDGLACQKLGAEIIGTTLSGYTTPETPEEPDLALVKTLSDAGCRVIAEGRYNTPAQAADAMRHGAWAVTVGSAITRLEHICQWYNTAMKKAVL
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
A7ZSB6
P22458
VTNC_RABIT
Serum-spreading factor
Oryctolagus
MAPLRPIFTLALLLWVVLADQESCKDRCTEGFNANRKCQCDELCSYYQSCCADYAAECKPQVTRGDVFTMPEDEYGPYDYIEQTKDNASVHAQPESPTVGQEPTLSPDLQTEGGAEPTHEVPLEPEMETLRPEGEDLQAGTTELGTSASPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDETAVRPGYPKLIQDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGILDPDYPRNISEGFSGIPDNVDAAFALPAHSYSGRERVYFFKGDKYWEYQFQQQPSQEECEGSSLSAVFEHFAMLHRDSWEDIFKLLFWGRPSGGARQPQFISRDWHGVPGKVDAAMAGRIYISGLTPSPSAKKQKSRRRSRKRYRSRYGRGRSQNSRRLSRSISRLWFSSEEVSLGPYNYEDYETSWLKPATSEPIQSVYFFSGDKYYRVNLRTQRVDTVNPPYPRSIAQYWLGCPAPGGQ
Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
P22458
Q02020
FIBB_CHICK
Fibrinogen beta chain
Gallus
ASVEYDNEEDSPQIDARAHRPLDKRQEAAPTLRPVAPPISGTGYQPRPPKQDKQAMKKGPIIYPDAGGCKHPLDELGVLCPTGCELQTTLLKQEKTVKPVLRDLKDRVAKFSDTSTTMYQYVNMIDNKLVKTQKQRKDNDIILSEYNTEMELHYNYIKDNLDNNIPSSLRVLRAVIDSLHKKIQKLENAIATQTDYCRSPCVASCNIPVVSGRECEDIYRKGGETSEMYIIQPDPFTTPYRVYCDMETDNGGWTLIQNRQDGSVNFGRAWDEYKRGFGNIAKSGGKKYCDTPGEYWLGNDKISQLTKIGPTKVLIEMEDWNGDKVSALYGGFTIHNEGNKYQLSVSNYKGNAGNALMEGASQLYGENRTMTIHNGMYFSTYDRDNDGWLTTDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGTYSWDMAKHGTDDGIVWMNWKGSWYSMKKMSMKIKPYFPD
Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots.
Q02020
Q9NYT6
ZN226_HUMAN
Zinc finger protein 226
Homo
MNMFKEAVTFKDVAVAFTEEELGLLGPAQRKLYRDVMVENFRNLLSVGHPPFKQDVSPIERNEQLWIMTTATRRQGNLGEKNQSKLITVQDRESEEELSCWQIWQQIANDLTRCQDSMINNSQCHKQGDFPYQVGTELSIQISEDENYIVNKADGPNNTGNPEFPILRTQDSWRKTFLTESQRLNRDQQISIKNKLCQCKKGVDPIGWISHHDGHRVHKSEKSYRPNDYEKDNMKILTFDHNSMIHTGQKSYQCNECKKPFSDLSSFDLHQQLQSGEKSLTCVERGKGFCYSPVLPVHQKVHVGEKLKCDECGKEFSQGAHLQTHQKVHVIEKPYKCKQCGKGFSRRSALNVHCKVHTAEKPYNCEECGRAFSQASHLQDHQRLHTGEKPFKCDACGKSFSRNSHLQSHQRVHTGEKPYKCEECGKGFICSSNLYIHQRVHTGEKPYKCEECGKGFSRPSSLQAHQGVHTGEKSYICTVCGKGFTLSSNLQAHQRVHTGEKPYKCNECGKSFRRNSHYQVHLVVHTGEKPYKCEICGKGFSQSSYLQIHQKAHSIEKPFKCEECGQGFNQSSRLQIHQLIHTGEKPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFRQASNLLAHQRVHSGEKPFKCEECGKSFGRSAHLQAHQKVHTGDKPYKCDECGKGFKWSLNLDMHQRVHTGEKPYKCGECGKYFSQASSLQLHQSVHTGEKPYKCDVCGKVFSRSSQLQSHQRVHTGEKPYKCEICGKSFSWRSNLTVHHRIHVGDKSYKSNRGGKNIRESTQEKKSIK
May be involved in transcriptional regulation.
Q9NYT6
P78795
EIF3G_SCHPO
Translation initiation factor eIF3 p33 subunit homolog
Schizosaccharomyces
MSSSKSLDWADDEDYGTGLPSIQTFDNPDGTKTMIEFRIDDNGKKVKVTRVIRKTVITERVQHAVAERKKWKKFGKEAGKNSGVDARTTSVGENVQLRLQLGWTTTKEEEQDEAALAAAKVKAKGSSVVRCRACKGNHFTAQCPYKSIIGPVDEPPLDASPVSSRASGALGEKGRYIAPHLRAGSGRESGDSMFKRERDDSATLRVTNLSDDTREEELRDLFRRFGGIQRVYLAKDKETGRAKGFAFVSYYDRDCAIKARDRLDGYGWNNLILRCEFSKPRD
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.
P78795
Q8IZ08
GP135_HUMAN
G-protein coupled receptor 135
Homo
MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSFSTVATAALGNLSDASGGGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAAVAAQALVLLLIFLLSSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGRNREEGYRTRNVDAFLPSQGPGLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTAVTKQPKSEAGDTSL
Orphan receptor. Has spontaneous activity for beta-arrestin recruitment . Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization .
Q8IZ08
W3X7K0
PFMAD_PESFW
Conidial pigment biosynthesis cluster protein D
Pestalotiopsis
MWTARLSSIAVLTQVVGTWADTITLNWEITWVNAAPDGFHRPVIGVNGKWPCPPIHATVGDTVVINMKNSLGNQTTGLHFHGINQLDTNYMDGASMVNSCPVVPGSSMTYSFTADEPGTYWYHSHNMAQYPDGLRGPLIIHDDNDPFDGEFDNEVILTISDWYHQQTLTLVQNMLVSSNDQWRPPLPDGMIVNEGGNTDIELDIGTTTRVRILNFGALTAFMLRFGSRDMDVIMTDASYVQRETIHQLRIAPGQRYDVLVSATKKDKGKNIPYLISMDLNRDFTVSGTWTFNQTGYLITDAKAPCTAKEVVQQWRPFDEALFTPLDEMPLLGPLDRTWTLNFALCKDMNNIPRMCFNDQTYVMQKTPTLYTAATVGNANTDPSVYGAVLPFIIEYGDVLEIVINNLDPAIHPFHLHGHQFQVVERPESGSGSFDGSSTANPVPPRRDVISINGGSYARLRITADNPGVFLFHCHIEWHVEMGLTATLIEAPEMLDGYDIPQAMIDSCKAQGYPVAGNAAGDTINVWDDSGYLTDPPSTYSGSQWPVPKGGNSQKSRPRRKPSGQSSQTRQISNMSGEFQHRITW
Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of dihydroxynaphthalene (DHN)-melanin, a bluish-green pigment forming a dark layer in the conidial wall that protects the conidia from UV radiations . The first step of the pathway is the production of the pentaketide 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN or T4HN) by the polyketide synthase PfmaE though condensation of acetyl-CoA with malonyl-CoA. T4HN is not stable and easily oxidizes into the stable form flaviolin . T4HN is also substrate of the hydroxynaphthalene reductase PfmaG to yield scytalone . The scytalone dehydratase PfmaJ then reduces scytalone to 1,3,8-THN . 1,3,8-THN is then substrate of the hydroxynaphthalene reductase PfmaI to yield vermelone (Probable). Vermelone is further converted by the multicopper oxidase PfmaD to 1,8-DHN (Probable). Finally the laccase PFICI_06862 transforms 1,8-DHN to DHN-melanin (Probable). The roles of the 5-oxoprolinase PfmaA and the proline iminopeptidase PfmaB within the cluster have not been elucidated yet (Probable).
W3X7K0
Q9PTQ7
DMRT1_CHICK
Doublesex- and mab-3-related transcription factor 1
Gallus
MPGDSPVVSKRAAPKPRRAAMPGDSPVVSKPPDGAGPGDKAGGLGKAAAQMAAAPAAGKKLPRLPKCARCRNHGYSSPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPVPLPSAPEPVVKKSSSSSSCLLQDSSSPAHSTSTVAAAAASAPPEGRMLIQDIPSIPSRGHLESTSDLVVDSTYYSSFYQPSLYPYYNNLYNYSQYQMAVATESSSSETGGTFVGSAMKNSLRSLPATYMSSQSGKQWQMKGMENRHAMSSQYRMCSYYPPTSYLGQGVGSPTCVTQILASEDTPSYSESKARVFSPPSSQDSGLGCLSSSESTKGDLECEPHQEPGAFAVSPVLEGE
Transcription factor that plays a key role in male sex determination. Acts both as a transcription repressor and repressor.
Q9PTQ7
A5VR03
RL2_BRUO2
50S ribosomal protein L2
Brucella
MALKHFNPITPGQRQLVIVDRSELYKGKPVKSLTEGLSKKGGRNNTGRITVRFQGGGHKRSYRFIDFKRRKLDVVGTVERLEYDPNRTAFIALIRYTDGELAYILAPQRLAVGDQVVAGNFVDVKPGNAMPLSSMPVGTIIHNVELKPGKGGQIARSAGTYAQLVGRDQGMAILRLNSGEQRLVSGACFASVGAVSNPDHGNINDGKAGRSVWRGKRPHVRGVAMNPVDHPHGGGEGRTSGGRHPVTPWGKPTKGKKTRSNKATDKFIMRSRHQRKK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
A5VR03
Q6MSP3
RL15_MYCMS
50S ribosomal protein L15
Mycoplasma
MKLNELKYTPGSKTKATIVGRGMASGKGKTATRGHKGQNSRSGGGVRPGFEGGQTPLFRRLPKVGFTSLNQKQYTILNLSDLETLGLEKIDHESLINSKIIKNNASLIKILANGTLTKKVDVKVNKISKAAKDAIEKLGGKVEVI
Binds to the 23S rRNA.
Q6MSP3
Q21SF4
RL1_ALBFT
50S ribosomal protein L1
Rhodoferax
MTQLTKKQKSFQGKVDSNKLYPLADALGLVKECATAKFDESIDVAVQLGIDAKKSDQVVRGAVVLPNGTGKTKRVAVFAQGAKAEEAKAAGADIVGMDDLAAMIKAGDMPFDIVIAAPDAMRVVGTLGQILGPRGLMPNPKVGTVTPDVATAVKNAKAGQVQFRVDKAGIVHSTIGRRSFDTDKLQGNLAALVDALTKAKPATSKGVYLKKVAVSSTMGVGIRVDLQSIAA
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
Q21SF4
Q39E95
NTPPA_BURL3
Nucleotide pyrophosphatase
Burkholderia cepacia complex
MPSSTPPALFPTLYLASQSPRRQELLQQIGVRFELLLPRPDEDAEALEAELPGEAADAYVRRVTIAKAEAARARLVASGKPASPVLVADTTVTIDGAILGKPANADDALSMLTRLAGREHAVLTAVAVIDADGELLPPALSRSSVRFAPASRDAYARYVESGEPFGKAGAYAIQGRAAEFIERIDGSHSGIMGLPLFETAALLRAARVAF
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Q39E95