accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q8H6Q1
DEF1_PETHY
PhD1
Petunia
MARSICFFAVAILALMLFAAYDAEAATCKAECPTWDSVCINKKPCVACCKKAKFSDGHCSKILRRCLCTKECVFEKTEATQTETFTKDVNTLAEALLEADMMV
Plant defense peptide with antifungal activity against F.oxysporum and B.cinerea.
Q8H6Q1
Q2YWA3
COPA_STAAB
Cu(+)-exporting ATPase
null
MANTKKTTLDITGMTCAACSNRIEKKLNKLDDVNAQVNLTTEKATVEYNPDQHDVQEFINTIQHLGYGVAVETVELDITGMTCAACSSRIEKVLNKMDGVQNATVNLTTEQAKVDYYPEETDADKLVTRIQKLGYDASIKDNNKDQTSRKAEALQHKLIKLIISAVLSLPLLMLMFVHLFNMHIPALFTNPWFQFILATPVQFIIGWQFYVGAYKNLRNGGANMDVLVAVGTSAAYFYSIYEMIRWLNGSTTQPHLYFETSAVLITLILFGKYLEARAKSQTTNALGELLSLQAKEARILKDGNELMIPLNEVHVGDTLIVKPGEKIPVDGKIIKGMTAIDESMLTGESIPVEKNVDDTVIGSTMNKNGTITMTATKVGGDTALANIIKVVEEAQSSKAPIQRLADIISGYFVPIVVGIALLTFIVWITLVTPGTFEPALVASISVLVIACPCALGLATPTSIMVGTGRAAENGILFKGGEFVERTHQIDTIVLDKTGTITNGRPVVTDYHGDDQTLQLLATAEKDSEHPLAEAIVNYAKEKQLTLTETTTFKAVPGHGIEATIDHHHILVGNRKLMADNDISLPKHISDDLTHYERDGKTAMLIAVNYSLTGIIAVADTLKNHAKDAIKQLHDMGIEVAMLTGDNKNTAQAIAKQVGIDTVIADILPEEKAAQIAKLQQQGKKVAMVGDGVNDAPALVKADIGIAIGTGTEVAIEAAGITILGGDLMLIPKAIYASKATIRNIRQNLFWAFGYNIAGIPIAALGLLAPWVAGAAMALSSVSVVTNALRLKKMRLEPRRKDA
Involved in copper export.
Q2YWA3
O80920
PYL4_ARATH
Regulatory components of ABA receptor 10
Arabidopsis
MLAVHRPSSAVSDGDSVQIPMMIASFQKRFPSLSRDSTAARFHTHEVGPNQCCSAVIQEISAPISTVWSVVRRFDNPQAYKHFLKSCSVIGGDGDNVGSLRQVHVVSGLPAASSTERLDILDDERHVISFSVVGGDHRLSNYRSVTTLHPSPISGTVVVESYVVDVPPGNTKEETCDFVDVIVRCNLQSLAKIAENTAAESKKKMSL
Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA . Can be activated by both (-)-ABA and (+)-ABA .
O80920
Q046I4
XPT_LACGA
Xanthine phosphoribosyltransferase
Lactobacillus
MKLLEERIRKDGEVLDGDVLKINSFLNHQVDPELMMQVGEEFKRLFENEKITKVLTCEASGIAPGIMAAYQLGVPMVFARKKKPSTLNDAVYWADVFSYTKKVNNKICVEKKFLSSDDHLLIIDDFLAHGEAVKGMLNIAKQANAAVAGVGVVVAKEFQGGSDWVKEHGYRLEALARISNFENNQVHFVGEK
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Q046I4
P13106
FER_BUMFI
Ferredoxin
Bumilleriopsis
ETYSVTLVNEEKNINAVIKCPDDQFILDAAEEQGIELPYSCRAGACSTCAGKVLSGTIDQSEQSFLDDDQMGAGFLLTCVAYPTSDCKVQTHAEDDLY
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
P13106
Q1XDN5
RPOB_NEOYE
Plastid-encoded RNA polymerase subunit beta
Neopyropia
MVQRISLKNKLLPDLVEIQRASFKWFLLEGLTEVLEIFPKISDPTSRLELQLFGNEYKIKFPRYSVRQAKNRDKTYSAQIYVPAKLTRKDIDLPSKNQEKNIKSLDLSSTHLQLSAEKQIKNKKYKKRLVFIGDLPIMTNRGTFIVSGTERVIINQIIRSPGIYYKQEIDKNGKQIYSASLISNRGSWLKFEIDPKGEIWIRIDKTHKVNAYIFLRAIGLNKDEIEKGLSKYAFLISASQIYSVKELAKEIGKNNIEEVTDEEALLIVYSKLRPNEPATVAVAKQMLYSRFFDPKRYDLGEVGRYKINKKLGLNIPKTFRVLSPQDILSSIDYLINIKDKNSGNLDDIDHLGNRRVRSVGELLQNQFRVGLNRLERIIRERMMICDIDSLSLSNLINPKPLIASVREFFGSSQLSQFMDQTNPVAELTHKRRISALGPGGFNKDRAGFAVRDLHPSHYGRICPIETPEGPNAGLIGSLATCARVNVFGFIETPFYPVNQGQVIYHNSPVYLTADEEDDFRVAPGDVKVSKQHYIEGDIIPVRYRQEFITTTPTQVDYIAISPIQVISAATSLIPFLEHDDANRALMGSNMQRQAVPLLYPEKPIIGTGLETKIARDSGMVVISRTSGHVNYVSANKIGIQDNSGRTVHYRLKKYYRSNQDTCINQRPIVWVGEKIVVGQTLADGASTDGGEIALGRNILVAYMPWEGYNYEDAFLISERLVYDDLYTSIHIEKYEVECRQTKLGPEEITREIPNVSDNSLKDLDRNGIVVGGSWVEAGDILVGKITPKGEADQLPEGKLLRAIFGEKARDVRDTSLRLPNAAKGRVVKVRVFTRQKGDELPPGTNAMIRVYVAQKRKIQVGDKMAGRHGNKGIISRILPKQDMPYLSDGTPVDIVLNPLGVPSRMNVGQVFECLLGLAGGYLGKRFKIIPFDEMYGAEASRALVNRKLKEASLITSNKWLFNDQHPGKMQVFDGRTGEPFDNPVTVGRAYMLKLVHLVDDKIHARSTGPYSLVTQQPLGGRAQHGGQRLGEMEVWALEAFGAAYTLQELLTVKSDDMQARNEALNAIVKGKPIPKPGTPESFKVLMRELQSLGLDIAVHKLKLFEDGQRRTVEVDLMSDSKDNRVDRSNYDTPPVDDFEQFLY
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q1XDN5
O76616
PID3_CAEEL
piRNA-induced silencing defective protein 3
Caenorhabditis
MVAHQKADFKSKWAMVVTVNNLNDKKRADLREFSEWFIETLRLEGAFIGHYFNYEAAPVTIVETLPGNFDSCTNAYQKIHKEHPQVVLVVHILPQSQSNEYEWMKVLASRYGFVRQGLLYDNCANRFQNVETDQNSVFRNMCQWIYRSGTAIVRNEGNACGILHGKDPKPTFDKVLFNSEDIKDSVFKVLHAEEEPRGADQENMLKISGYPGMLNTFGIAQLLTPYRVNGITITGAQSAVVALENKFQVYQAVQDFNGKKLDRNHKLQVSSLVVSSPAVPLEWPSLKKSKKLVEQVGKPIRLSKVSS
Component of the pid-1 and tost-1 variants of the PETISCO complexes, which have roles in the biogenesis of a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and embryogenesis, respectively . Within the pid-1 variant of the PETISCO complex may stabilize 21U-RNA precursor molecules . Promotes the biogenesis of 21U-RNAs . Required for chromosome segregation and cell division in early embryos .
O76616
B8GUJ5
RUVA_THISH
Holliday junction ATP-dependent DNA helicase RuvA
Thioalkalivibrio
MIGRLRGELVSKQPPFLLLDVQGVGYEIEAPLSTFYDLPEPGGQVTLHTHLHVREDAHVLYGFASESERALFRSLIKVTGVGAKMALAILSGMTASEFSRCVMDGDVASLVRLPGIGRKTAERLVVEMRDRLGSLPAAVTLTGGKPAAAAARAPDPVSDAVSALVSLGYKPQEASRLISAVEGEAERSEDLIRLALKATLK
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
B8GUJ5
P0ADR2
YGDD_ECOLI
UPF0382 inner membrane protein YgdD
Escherichia
MTSRFMLIFAAISGFIFVALGAFGAHVLSKTMGAVEMGWIQTGLEYQAFHTLAILGLAVAMQRRISIWFYWSSVFLALGTVLFSGSLYCLALSHLRLWAFVTPVGGVSFLAGWALMLVGAIRLKRKGVSHE
May be a peptide transporter or a protein that facilitates peptide internalization .
P0ADR2
B1L108
LGT_CLOBM
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Clostridium
MNPIAFHVGNLAIRWYGVIISIGAALGLLLAMYNCKIREASYDEFINMFLIAFPSAIIGARLYYVIFEFEDYRDNLINIFNTRQGGLAIHGGIIFGVLAVYIYLKYRKENFFEYVDVAAPSIILGQAIGRWGNFFNSEAHGGPVTKEFISKFPQFIQKGMFIEGTYYHPTFLYESIWNFIVCIFLVYLLKKTKKKGIVFMAYIGLYSLGRFFIEGLRTDSLYLGSIRVAQLISVLGIILSIFFIYNIIKKEKRY
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
B1L108
Q8TS71
MTBC2_METAC
Dimethylamine corrinoid protein 2
Methanosarcina
MASKEELLQELSDAIVSCKKDRVIAAVEKAKEVMEPAEIIEKGLAAGMNQVGTLFERGKLFLPHVMMAADSMTAGVNILEAEMPAGTETKKLGVIVNGTVEGDVHDIGKSIVSTMLQSAGFEVHDIGRDVPIKNFVEKAKEVNADMIGLSALMTTTMQGQRDVIELLKEEGMRERVKVMVGGAPATQAWADKIGADCYAENASEAVAKAKELLLGK
Acts as a methyl group carrier between MtbB and MtbA.
Q8TS71
B3EFY2
RL13_CHLL2
50S ribosomal protein L13
Chlorobium
MSKTLSFKTYSAKPAEVERKWYVIDAEDQILGRMAAEIAKVLRGKHKPQFTPHIDTGDFIVVTNAEKVALSGKKIEYKTYFHHSNYPGGGKFDHVKDLLKKKPEKVIEHAVWGMLPHNNLGRQLFKKLKVYAGSEHPHTAQCPVELKVN
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
B3EFY2
A0A411PQN4
AGN8_PAEDI
Agnestins biosynthesis cluster protein L8
Paecilomyces
MAKDPTFEEVTGCQRALFEWADSYDTKDWERLKKCVAPTLRIDYRSFLDKLWEAMPSDEFILMASDPRFLGNPLLKTQHFVGLSTWQKISPDEIEGTHQLRVPHQRYTDSNMKEVAVKGHAHGIATMWYKRVEDEWKFAGVCPQIRWAEFDYDKVFAEGKDHFGENGGNGEHAV
Dehydratase; part of the gene cluster that mediates the biosynthesis of agnestins, dihydroxy-xanthone metabolites . The pathway begins with the assembly and cyclization of atrochrysone thioester by the non-reducing polyketide synthase Agnpks1 . The atrochrysone carboxyl ACP thioesterase AgnL7 then breaks the thioester bond and releases the atrochrysone carboxylic acid as the first enzyme-free intermediate . The decarboxylase AgnL1 then catalyzes the concerted decarboxylation-elimination required to convert atochrysone carboxylic acid into emodin anthrone, which is further oxidized to emodin by the anthrone oxygenase AgnL2 . Emodin then undergoes reduction catalyzed by the oxidoreductase AgnL4 to yield the dihydroquinone tautomer which is the substrate for reduction by the short chain dehydrogenase AgnL6 reduction to produce hydroxyketone, followed by AgnL8 dehydration and likely spontaneous autoxidation to chrysophanol . Baeyer-Villiger oxidation by the oxidase AgnL3 leads to monodictyphenone via cleavage of the C-10/C-10a bond of chrysophanol . Alternative cleavage at the C-4a/C-10 bond of chrysophanol leads also to the formation some cephalone F . Further conversion to agnestins A and B, requires reduction to dihydro-monodictyphenone, oxidation to agnestin C probably via an epoxide, and rearrangement to either agnestin A or agnestin B directly, although agnestin A or agnestin B can also interconvert . Within the cluster, AgnR1 is the only unassigned oxidoreductase present which could be involved in this conversion. However, AgnR1 seems not to be involved in this step, and thus genes involved in the proposed oxidation/reduction may be located elsewhere on the genome . Further agnestin A derivatives are probably formed by spontaneous decarboxylations, dehydrations and methanolysis reactions .
A0A411PQN4
A5F0H9
ECTC_VIBC3
N-acetyldiaminobutyrate dehydratase
Vibrio
MIVRTLEECRQSERRVVAENWESVRMLLKDDHMGFSFHITTIYANTQTHIHYRNHLESVYCMSGEGEIEVVGGKTYPIQPGTLYILDQHDEHYLRAFSSEMVMACVFNPPLTGHEIHDAEGVYPLDKSELISQCHKEK
Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant.
A5F0H9
B5YDV7
RS8_DICT6
30S ribosomal protein S8
Dictyoglomus
MTVTDPIADMLVRIKNASMRRHPTVDVPYSKMKEKILEILLREGYIARYEVIGEIPQKYIRVYLKYKGKTPVIQDVKRVSKPGRRYYVNKEEIPRVLGGLGIAILSTSKGIMTDKEARLLGVGGELICMVW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
B5YDV7
Q18H64
FLPA_HALWD
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
Haloquadratum
MKASSSLPDGVQRRQFDNRSRLTTHGTTVYGEPRDTDGWRLWDAGRSKLGAMFKLDIETGLTGGESILYLGAASGTTVSHVADFAGPTYAIEFAPRPVRDLLEVATTRPNLIPLLCDARQPETYAHVVETDIEYLIQDVATRGQATVALRNRQFLAPDGKLILMIKARSEDVLSDPEDVFDTIISTLREGYIIQTRQRLDRFHDDHLAVVATPNM
Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
Q18H64
B2V847
DXR_SULSY
2-C-methyl-D-erythritol 4-phosphate synthase
unclassified Sulfurihydrogenibium
MLKVGILGSTGSVGSQALDVIRKYKDQIKVELLGASKLSENLINQIKEFKPSYVYVENAEEKSIDDIKVLVGEDGLRRAVNLDLDLFINAIAGIKGILPTYLLLKYNKTLATANKEAIICLGELLKDKYKKILPIDSEHSAIFQILKDSNQKEVRRIILTASGGPFVNMPAEDFENITVKQALIHPRWSMGKKITIDSATLMNKGLEVIEAHYLFSMPYEKIDVLIHPESIIHGMVEFVDGTVISNMSNPDMKIPISYALFYPERKFLSDNYLDFTKIKSLNFLKPDTEKFPLLKLAVECGKKGGVYPTVLTVADEIAVNYFLEERIKFTDIHKIILETLEKFDYNKLDSVDDIFYIIDKTINLATEIAKKYGST
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
B2V847
O80963
ACCR2_ARATH
Protein CRINKLY 4 RELATED 2
Arabidopsis
MQPNSHIFVIITISSLIITVSAYGSTGTIAAAFGENGFFCAIDASGKQEVICWDRGNTNRSLNRPPGEISGYSPPMTSLSGGEGFLCAITSNTSRAFCWNLEDPSENLVPRAFQYNSYLQIASGNNHVCAISGLYYSGPDYGPVHCWEYSDNTNFTSGLLWNSSFHNPYIDSLMFRKIVSGDGFSCGVTKDGDLVCWGPKSNLLNFSNNEEFEVLASGRNSVCGVSKDSGQLHCFGDETEFGSLPNRPRFIALSAGANHYCGIREDDHGVECWGRNLNSSSSSSAPNTSGFVAISSSDSTTCGVRELDLVLDCWRVHDSSKADYSPPLELCSPGMCSPRGNCGDGWFAFNASILKESELTSLCSFHNLNICLRCGISCLEGYFPSSTCNPNADRVCTPCSLCQNSSCYGICKIRATKSKEHEQKEQREVRRLVIIIGCSVLGFLVMLIGLSFIPKMTKGSKRDDEERSKMTCCFCFDKNSVEADPDPVPHQSVLLPTAVSLGETKIFRLSELKDATHGFKEFNELGRGSFGFVYKAVLSDGIHVAVKRANAATIIHSNNRGFESELEILCKIRHNNIVNLLGYCSEMGERLLVYEYMPHGTLHDHLHGDLSQLDWSMRLKIMLQAARGLDYLHNEVDPPIIHRDVKTSNILLDGEMCARIADFGLVSSNERDSSNSDREGDVYDFGIVLLEILSGRKAIDRESDPAGIAEWAVPLIRKGKAAAIIDRNICLPRNVEPLLKLAELAELAVRENSNERPNIRNILCFLDLIVKSGLTF
Serine/threonine-protein kinase with low activity.
O80963
B3QQD1
APT_CHLP8
Adenine phosphoribosyltransferase
Chlorobaculum
MPIKSRIRTVPDYPKKGIMFRDITTLIKDPVGFRLVIDNMTQHYLSNGIDFDVIVGIEARGFIIGGALSYTLGKGFVPVRKPGKLPADVVQLEYDLEYGSDKIEMHTDSLVKGQRVLLVDDLLATGGTALAAAALVEKLGGVVASMGFIVNLPDVGGEKKIRDKGYNIFSLTEFEGD
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
B3QQD1
A9IHE2
SYDND_BORPD
Non-discriminating aspartyl-tRNA synthetase
Bordetella
MRTCYTGEVCRDHLGQTVTLYGWVNRRRDHGGVIFIDLRDRAGLAQIVFDPDNAAFATAERLRNEFCIRVTGLVRPRPEGTANPELASGEVEVLCKEVEILNASITPPFQLDDDNLSETTRLTHRVLDLRRPQMQRNLMLRYRVSIEVRKFLDQLGFIDIETPMLTKSTPEGARDYLVPSRVNAGHFFALPQSPQLFKQMLMVSGFDRYYQITKCFRDEDLRADRQPEFTQIDCETSFLNEVEIRQIFEDMIRHVFKTVQNVELPAPFPQMTWTEAMQRYGSDKPDLRVSLEFTDVTDVMRDVDFKVFAAAATAPGSRVVALRVPGGAELSRSEIDAYTQFVGIYGAKGLAYIKVNDASKGREGLQSPIVKNLHDAALAELLKRSGAQSGDIIFFGADRAKIVNDAIGALRVKIGHSEFGKKAGLASSDWKPLWVVDFPMFEYDEEDGRYTAAHHPFTSPKDGHEDFLESDPSKAFAKAYDMVLNGWEIGGGSVRIHREEVQSKVFRALKIGAEEAREKFGFLLDALQYGAPPHGGIAFGLDRIVTMMTGAESIRDVIAFPKTQRAQCLLTQAPSEVDEKQLRELHIRLRNVEVK
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
A9IHE2
Q4K6J1
MURD_PSEF5
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Pseudomonas
MSLIASDHFRIVVGLGKSGMSLVRFLASRGVAFAVADTRENPPELATLRRDYPQVEVRCGELDVDFLCRADELYVSPGLALATPALQAAAARGVKLSGDIELFARNAKAPIVAISGSNAKSTVTTLVGEMAAAAGKRVAVGGNLGTPALDLLSDDVELYVMELSSFQLETTDQLGAEVATVLNISEDHMDRYSGLPAYHLAKHRIFRGARQVVFNRQDALTRPLIGEGLPCWTFGLSKPDFKAFGLREEDGEKYLAFEFQNLMPVRELKIRGAHNQSNALAALALGHAVGLPFDAMLAALRTFAGLEHRCQWVRDLDGVAYYNDSKATNVGAALAAIEGLGADIEGKIVLIAGGDGKGADFKDLRGPVAANCRAVILMGRDSDQIGEAIGDAVPLIRVGSLQEAVEQCRATAQPGDVVLLSPACASFDMFKNYEDRGHQFVRIVEELA
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Q4K6J1
P9WMD2
CHLER_MYCTO
HTH-type transcriptional repressor MT1396
Mycobacterium tuberculosis complex
MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR
Negatively regulates the expression of the efflux pump MT0201 upon chloramphenicol exposure. Acts by binding to the MT0201 promoter region.
P9WMD2
A5CRA6
HRCA_CLAM3
Heat-inducible transcription repressor HrcA
Clavibacter
MVSERGLDVLRVIVQDYVSSREPVGSKSIVERHAFGVSAATIRNDMALLEEEELIAAPHTSSGRVPTDKGYRLFVDQLADVRPLTPAQRQAIHVFLGESVDLDDVLARTVRLLAQLTNQVALVQYPSLATSHVKHVELVALSTTRVLTVLITDTGRVEQRVVELAGDPDDAFLAVMRTRINQAVGGLGLAEAATRLETLSDEVEPAQRAAASVLAGTLVEQVLANRQERLLLAGSANLARTERDFPGSISPVLEAIEEQVVLLRLLGEMEADQHGVSVSIGRENAPFGLGETSVLTSGYSSSGGVLARLGVLGPTRMDYSTNMASVRAVARYLSRLLEER
Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.
A5CRA6
D3E3N9
EF2_METRM
Elongation factor 2
Methanobrevibacter
MSRRDKMIAKIKELMYKPEYIRNIGICAHIDHGKTTLSDNLLAGAGLISEDLAGEALGMDTKKDEQERGITIDAANASMVQEYEGEQYLINLIDTPGHVDFGGDVTRAMRAVDGAVVVVCAVDGVMPQTETVLKQALRENVKPVLFINKVDRLINELKLGPEELLKQLTSIIVEVNALIKSLAPKDKKNEWMVNVEEGSVAFGSAFKNWAINIPKMQETKFTFKDIIDYCNEGKEDELKQLLPLTEVLLNMVVKHLPSPNVAQVYRVPKIWDGDIESEVGQTMIKMSPDGPLAGMITNVAVDKHAGIVATCRIYGGTLEKSSEIYLVGSHGKARVQQAGIFMGAETIDTGKVPVGNIAYLTGVKGASAGETICSADCIIDEFEPIDHISEPVVTVAVEAKNTKDLPKLIEVLRQVSKEDPTIKVEINETTGEQLISGMGELHLEVVTNRIINDKKLEILVSEPIIVYKESVLGHSPVIEGKSPNKHNRFYIDVQPLDKPLYDALIEGDLKEGRIKTKETAQDFIELGMDKEEARRVWDVYNRSMFINMTRGIQYLDEVKELLLEGFEAALKDGPLANEEAVGLKFILSDAKLHEDAVHRGPAQVLPAIKKAIYASIMSANPCLLEPIQKVFISAPLEYMGNCNKDIQNRRGRIIGQETKGVIAEMDFEVPIAKMFGFAGDIRSATGGKGDFSTEMKGFETLPIYLQDDIVRQIRTRKGLSPEPYGPEHYSA
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
D3E3N9
B3QQS6
RL11_CHLP8
50S ribosomal protein L11
Chlorobaculum
MAKKITGFIKLQIPAGGANPAPPVGPALGQKGVNIMEFCKQFNAKTQSEAGMIIPVVITVFSDKSFTFVTKTPPAAVLLLKEAKLQKGSGEPNRNKVGTVTMEQVRKIAELKKPDLNSVDIEGAAQMVMGTARSMGIVVEG
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
B3QQS6
A6LTK6
ILVD_CLOB8
Dihydroxy-acid dehydratase
Clostridium
MRSDVITKGSKSAPQRSLLSALGLTKEEMERPLVGIVSSQNDIVPGHMNLDKIVEAVKMGVSMAGGTPIVFPAIAVCDGIAMGHEGMKYSLVTRDLIADSTEAMAMAHAFDALVMVPNCDKNVPGLLMAAARVNIPTIFVSGGPMLAGKVDGCKTSLSSMFEAVGAYNAGKITAEKLDEYENNVCPTCGSCSGMYTANSMNCLTEVLGMGLQGNGTIPAVYSERIKLAKHAGMKIMELLEKNIRPRDIMTEDAFMNAMTMDMALGCSTNSMLHLPAIAHEVGFDLNVDIANEISSKTPNLCHLAPAGHTYIEDLNDAGGIYAVMNEINKLGLLKTNLITCTGKTVGENIEGCINKNPEVIRPVKNPYSQTGGIAVLKGNLAPDSCVVKRSAVVPKMLKHEGPAKVFDCEEDALEAINTGKIVAGDVVVIRYEGPKGGPGMREMLNPTSAIAGRGLGSSVALITDGRFSGASRGASIGHVSPEAAVGGNIALVEDGDMIQIDINANTINFLVSDEELARRKANWKPRKPKITTGYLARYAALVTSGNRGAILDIPKF
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
A6LTK6
C1DSX5
KAD_AZOVD
Adenylate monophosphate kinase
Azotobacter
MRVILLGAPGAGKGTQARFITERFGIPQISTGDMLRAAVKAGSPLGLKVKGVMDSGGLVSDDIIIDLIRERIAQPDCARGFLFDGFPRTIPQAEALRDAGVSIDHVLEIAVDDEEIVSRMAGRRVHAASGRVYHDLHNPPKVAGKDDETGEDLIQREDDKEETVRHRLALYHSQTKPLVDFYQRLAATTGTPRYTRVEGIGSVSEITARVQAALA
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
C1DSX5
A3CRB1
MNMG_STRSV
Glucose-inhibited division protein A
Streptococcus
MSHNFTESYDIIVIGAGHAGVEASLAASRMGCKVLLATINIEMLAFMPCNPSIGGSAKGIVVREVDALGGEMAKNIDKSYIQMKMLNTGKGPAVRALRAQADKELYSKEMRKTVENQENLTLRQTMINEILVEDGKVIGVKTATHQEYAAKAVIVTTGTALRGEIIIGDLKYSSGPNHSLAAIPLADNLRDLGFEIGRFKTGTPPRVKASSINYDVTEIQPGDEKANHFSYTSRDEDYVKDQVPCWLTYTNAESHEIIQNNLHRAPMFSGIVKGVGPRYCPSIEDKIVRFADKERHQLFLEPEGRDTEEVYVQGLSTSLPEDVQKDLVHSIKGLENAEMMRTGYAIEYDMIMPHQLRATLETKKISGLFTAGQTNGTSGYEEAAGQGIIAGINAALKIQGKQELILKRSDGYIGVMIDDLVTKGTVEPYRLLTSRAEYRLILRHDNADMRLTEMGREIGLVDDERWARFEIKKNQFDNEMKRLESIKLKPVKETNAKVEALGFKPLTDAVTAKEFMRRPEVSYQDVVQFIGPAAEELDEKIIELIETEIKYEGYISKALDQVEKMKRMEEKRIPANIDWDDIDSIATEARQKFKKINPETIGQASRISGVNPADISILMVYLEGKSRSISKNQAK
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
A3CRB1
B1A923
ATPI_CARPA
F-ATPase subunit IV
Carica
MDVISCSSNTLKGLYDISGVEVGQHLYWQIGGLQVHAQVLITSWVVIAILLGSAIIAVRNPQTIPTAGQNFFEYVLEFIRDVSKTQIGEEYGPWVPFIGTMFLFIFVSNWSGALLPWKIIQLPHGELAAPTNDINTTVALALLTSVAYFYAGLTKKGLGYFSKYIQPTPILLPINILEDFTKPLSLSFRLFGNILADELVVVVLVSLVPLVVPIPVMFLGLFTSGIQALIFATLAAAYIGESMEGHH
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
B1A923
Q2K7G6
COBT_RHIEC
N(1)-alpha-phosphoribosyltransferase
Rhizobium
MSVSGLPFDDFRTLLRELPGPDARALAAARERDAQLTKPPGALGRLEEIAFWLAAWTGRAPAVNRPLVAIFAGNHGVTRHGITPFPPAVTQQMVENFAAGGAAINQICVAHDLGLKVFDLALDYPTGDITEEAALSERDCAATMAFGMEAIAGGTDLLCIGEMGIGNTTIAAAINYALYGGSARDWVGPGTGSEGDMLERKIAAVEKAVALHSDHLDDPLEIMRRLGGREIAAMAGAILAARIERIPVLIDGYVATAAAAILKAANPAALDHCLIGHVSAEPGHLRSIEMLGKTPLLALGMRLGEGTGAALAAGIVKAAAACHSGMATFAQAGVSGKH
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Q2K7G6
A9IZA2
TRMD_BART1
tRNA [GM37] methyltransferase
Bartonella
MKFQARVLTLYPEMFPGFLGYSLAGHALERGIWSLETVQIRDFALDKHHSVDDTPAGGGAGMVMRADVLAAALDHCPQDSPRLLMSPRGRPFDQAYARRLADDSGITLVCGRFEGVDERVIEARELEEVSIGDYILSGGETAALVILDAIIRLLPGVMGNKASAKCESFENGLLEHPQYTRPSLFEGREIPPVLTSGHHKAIADWRQSQAELLTRQRRPDLYARYDKNRQKT
Specifically methylates guanosine-37 in various tRNAs.
A9IZA2
B0SXB0
THIG_CAUSK
Thiazole synthase
unclassified Caulobacter
MNAHVPPESVSAAEDSWTVAGRTFRSRLIVGTGKYKDYATNAAAAKAAGAEIVTVAVRRVNLTDPTQPLLIDYVKPTEFTYLPNTAGCFTGEDAVRTLRLAREAGGWDLVKLEVLSDPKTLYPDMEETLRSLKLLVSEGFQVMVYCSDDPVYARKLEEAGAVAIMPLGAPIGSGLGIQNRVNLRIIVENAGVPVLVDAGVGTASDAAIGMELGCDAILMNTAIAEAKDPIRMARAMKHAVIAGREAYLAGRMQKRLYADPSSPLGGLI
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
B0SXB0
Q93Z29
ALMT5_ARATH
Aluminum-activated malate transporter 5
Arabidopsis
MGGKMGSVPEQNTEKLLWQSSDVADSRDSKFRCCSWRALYEAPAKLYALGHSDRRKLYFSIKMGIALALCSFVIFLKEPLQDASKFAVWAILTVVLIFEYYVGATLVKGFNRALGTMLAGGLALGVAQLSVLAGEFEEVIIVICIFLAGFGASYLKLYASMKPYEYAFRVFKLTYCIVLVSGNNSRDFLSTAYYRILLIGLGATICLLVNVFLFPIWAGEDLHKLVAKNFKNVANSLEGCVNGYLQCVEYERIPSKILTYQASDDPLYSGYRSAVQSTSQEDSLLDFAIWEPPHGPYKTFNHPWKNYVKLSGAVRHCAFTVMAMHGCILSEIQASPEKRHVFSNELRRVGNEGAKVLRLFGEKVEKMEKLSLSLGEILKDVQRAAEALQMKIDSKSYLLVNSESWAAIKEQAEAEEARENDQEAKDDETKVIKSLSQIWDTNNNNNHQSNDQSQHWMSTESMMLKNREMWPSMSFIDGTVVNEIECKVYESASSLSLATFASLLIEFVARLQNIVNAFEELSTKAGFKDAVDQIPKV
Malate transporter.
Q93Z29
C6E4P3
RS8_GEOSM
30S ribosomal protein S8
unclassified Geobacter
MCMTDPVADMLTRIRNAGMAKHQKVDIPSSNLKVSLATVLRAEGFIKNFKVIADNKQGILRVYLKFIDEKEPVINEIKRISKPGGRVYVNSDKIKQVKNGLGVAILSTSKGLVTDKTAREMGIGGEVLCTVW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
C6E4P3
Q8DEC6
OBG_VIBVU
GTP-binding protein Obg
Vibrio
MKFVDEAVIKVQAGDGGNGVVSFWREKFVTKGGPDGGDGGDGGDVYIQADENLNTLIDYRFQRFYEAERGQNGSGGNCTGKRGKDITLRVPVGTRAVDIHTNEIVAEVAEHGKKVMVAKGGWHGLGNTRFKSSVNRAPRQKTMGTKGEIRELRLELLLLADVGMLGLPNAGKSTFIRAVFAAKPKVADYPFTTLIPSLGVVSVVPEKSFVVADIPGLIEGAADGAGLGIRFLKHLERCRVLLHMIDIFPIDQSDPVQNALTIIDELEQYSEKLANKPRWLVFNKVDLVSEEQADEIIQEVIDALGWEEQYFKISAVNRQGTKELCYKLADFMEQLPREEQEVSEEEKVNFMWDYHPDANQGEVITEDDDDDWDDWDDEEDDGHVIYVRE
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Q8DEC6
A9XFZ7
DEF_COPTR
Defensin coprisin
Copris
MAKLIAFALVASLCLSMVLCNPLPEEVQEEGLVRQKRVTCDVLSFEAKGIAVNHSACALHCIALRKKGGSCQNGVCVCRN
Potent broad-spectrum antibacterial peptide against both Gram-positive (B.subtilis, S.epidermidis, and S.aureus) and Gram-negative bacteria (E.coli, S.typhimurium, and P.aeruginosa) . Is also active against all antibiotic-resistant bacterial strains tested . Induces apoptosis in C.albicans, but does not disrupt the fungal plasma membrane at all . Acts by permeabilizing the bacterial cell membrane, but not human membranes . Also shows potent anti-inflammatory activities, since it reduces both LPS-induced nitric oxide release and pro-inflammatory cytokine production . Anti-inflammatory activities are initiated by suppressing the binding of LPS to toll-like receptor 4 (TLR4), and subsequently inhibiting the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and nuclear translocation of NF-kB (TNFRSF11A) . Does not show hemolytic activity against human erythrocytes .
A9XFZ7
Q8VUS8
QADG_PARDE
Quinohemoprotein amine dehydrogenase catalytic subunit
Paracoccus
MNALVGCTTSFDPGWEVDAFGAVSNLCQPMEADLYGCADPCWWPAQVADTLNTYPNWSAGADDVMQDWRKLQSVFPETKGSS
Catalyzes the oxidative deamination of a wide range of primary aliphatic and aromatic amines . The physiological electron acceptor is the constitutive cytochrome c550 .
Q8VUS8
P19237
TNNI1_HUMAN
Troponin I, slow-twitch isoform
Homo
MPEVERKPKITASRKLLLKSLMLAKAKECWEQEHEEREAEKVRYLAERIPTLQTRGLSLSALQDLCRELHAKVEVVDEERYDIEAKCLHNTREIKDLKLKVMDLRGKFKRPPLRRVRVSADAMLRALLGSKHKVSMDLRANLKSVKKEDTEKERPVEVGDWRKNVEAMSGMEGRKKMFDAAKSPTSQ
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
P19237
A8AA22
RNP1_IGNH4
Rpp29
Ignicoccus
MKHTPKNVIYHNLVGLRVEVLAHPDPSMKGLKGRIIDESKSFLTIEKDNGELVKVQKLGTFVLVLPSGRKVEVRGELLRGRPEERLKKFLKA
Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.
A8AA22
Q54K91
ACH1_DICDI
Acetyl-CoA deacylase
Dictyostelium
MHKIVQQGSKSLIESRIKRKSLLSKVVTDVSQLIPYFQNGHYVSMGGFAGTGYPKVVPIALADHVEKNGLQGKLKMNLFVGASVGPETEDRWAMLDMIDKRYPHQNGHHIRNGINSGRIRFADQHLSTFASDLLAGYYTLDKPHGSKRTMDIAIVEATEITEDGCIVPGASVGITPEILQMADKIIIEINTSLPSFKGLHDMVKIALPPFSKPYQITRVDDRIGLEAFPVDPEKIIAIVESQLPDNTSVGAPEDETSSAIANNIVQFFIHEIEQGRFPKNLLPLQSGIGSIANAVIGGLSKGPFDNLSVWTEVIQDTFLDFFDNGKLKFASATSLRFSPPGFNRLFNNWENYKSKIILRNQAISNAAELISRVGCIALNTPCEVDIYGHVNSTNTMGSKMLNGLGGSGEFLRNSRISIVHTPSTRPTKTDPHGISCIVPFASHIDHTEHDIDIIVTEQGLADIRGLAPYERAKVIIQNCAHPIYKPILMEYLETSRQICLKNHMGHEPHQLDKAFKFYTNLSEKGTMKIDKW
Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.
Q54K91
Q0CP15
NST1_ASPTN
Stress response protein nst1
Aspergillus subgen. Circumdati
MAPSQHPKSAAAPATTSDQMSTASSRPTNGTAHTSAETAYPSSMTDSKPTQSGPGSRASDEQDADEAYSNHSEQHMDHSNPDGHPSKPSGRKKKKKAKKGRAGSQTLGDESSTPLSTPSVSMSHPLPPPLPPHLGTRTILKSAKDRSIWNTSTQEERENIKTFWLELGEEERRQLVKVEKDAVLKKMKEQQKHSCSCTVCGRKRTAIEEELEVLYDAYYEELEQYANNNQGSFEKGSPIVPPPRLYQPPLRSPGQHTRTQGQFHPSRGRIHEITEDEEDLEEDYDDEEEDDDEPYSDDEFEDEETRAARADFFAFGNSLTVKDGILTVADDLLKNDGKHFIDMMEQLAERRMQREEDTQYNIAAAHQSLHSGHNHPPYDEEDYDDEEDEEYDSQEEDDYDEDEMDTMTEEQRMEEGRRMFQIFAARMFEQRVLTAYREKVAEQRQQKLIEELMEEQTRTEQKNAKKAREAEKRKEKKRLQKQAKEEEKARREAEKAAEEAAAKAEQEKKLEEQRRKREEQRKKREAERKAQEEERARKEAEKQRRLREERERQAEAERKHREQKEQEKKKREEARRKEREERELREKKAKEERERKAQEDQKKANQETPETKRTSHLGPVPIPANLQPQGSSSHLQSPHLQSASPAVPKAPTPAKARQPSQQGSHGSSPRSQQASTEPFHTSISPRSMAPSQSSGASSVASKQGYGQQPMLHHPQPSTPLSPLGSVNRSLPPGFASAGLPSNPPGLPGMVPRPPIGHELPTYPPHSGPLMNQLRGFPAPNGIPIPPGINGTRPLAPGRGFPLEAAPGLPFHTQQPIAGAFASHQGGMSHGHSRQPSGSFERSPLEPHAQPFPISRPSPIKRPPSTQQEQSDANRATQRDVDNLSAQLGSSALLDDTDIPFTSNLSQSLPGATAPGSLPGPTRASFGAPSLFPDPLASKPGGFPMGPGVGANTWGTQIPFVSSAFPGAPAWGTAHGSGWSNNAFGSGGHHRAHTSRPVAIRLLVIQACKQLDTMSSSKAGSGYHDVKIVLQQVEQLRPSNEPSIPLKEMLDICDTEGNTQNGGGSFSIKKDETGEFVKFEPDNNSAASGHRGSIVPGEIGSPVPSSSMPAFGGIGNTPSVLRQFSSPTGF
May act as a negative regulator of salt tolerance.
Q0CP15
A1C777
EIF3D_ASPCL
Eukaryotic translation initiation factor 3 subunit D
Aspergillus subgen. Fumigati
MAPVSIADLVAALPSEDSWGPATPSDNMLEGVPYAPFSKGDKLGRMADWTSDSKDRDRAGRQAYNRNYRDQQVYGAGTSSLFNVQVAEDESSFSVVDNTRTTTKRTFGRGGGTVFRGRAQRGGAGQRGGRAGFQRVGAGRGQGGDRYYDNRGGRGNRGRRSGWKDYDKPQRTREPSVNVRPDWTMLEEVDFSRLSKLNLEAPEGEDLDSYGFLYYYDRSYDKAPVKNAERRLQALDRAAYNVTTTQDPIIQELAEKNEATVFATSDILSMLMCAPRSVYSWDIVIVHQGNKIYFDKREGASIDLVTVNENAADAPLEVTDSSGKQESLNTPSALALEATFINHNFALQTVVESEDSKVGFSHPNPFYNASEETEPLASKGYKYRRFDMSLQEDEEPLNLIVRTEVDAVMKNPVSGEEQQLVVKALNEFDSKAPGSGGALDWRSKLWSQRGAVVATEMKNNSIKLARWATQAILAKADAMKLGFVSRANPRSAAGHVVLGVVSYKPRDLAAQMNLNLGNGWGIVRTIVDRIQALDANEEEDKVTKYVLIKDPNRPVLRLYSVPANTFEEDDEAADEQEEKATEESEE
mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.
A1C777
O94295
PUS2_SCHPO
tRNA-uridine isomerase 2
Schizosaccharomyces
MTSISKRKNQQEHIPAEDLETPKLPKREKIEGTKESNKVRIIILLGYSGYGYHGIQINNPLKTIEGDVVAVLKKLGYLKTNNIDAEHLCIARAARTDKGVHTLRNLISLNLFVDKPLDISLLKTELNEALCSQIRVWSVFPAPKYFNPRISCESRTYEYLIPSFALLPPKPSCPLFKKMQKNLSRKLDNELERNLVYSMNDLISFWNTVKLKQKEIQEMFDTNKDAFTNPFKGMFYEKPIPAGIVIPPQAKLKKALKQAEYYCYMNYRIKEDRLKVLQQLLKKYEGRHNFHNFTVTDDSTSPSNYRFIESVTCGTPFVYENWEWIPVTIKGNSFMLNQIRKMMAHVLMIIRSCAPTGLIDKAFDPNITMNISKSPGHVLLLKDIKFSSYNDSVTDGLEKIQFDCFEEDILSLKIKTIYPDIIKLEQKEKLFFSFLSYIDQHTGHQFDYLFG
Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr).
O94295
O64896
TPPA_ARATH
Trehalose 6-phosphate phosphatase
Arabidopsis
MDMKSGHSSPVMTDSPPISNSRLTIRQNRLPYSSAAATAISQNNNLLLTVPRKKTGILDDVKSNGWLDAMKSSSPPPTILNKDNLSNDATDMTYREWMQLKYPSALTSFEKIMSFAKGKRIALFLDYDGTLSPIVEEPDCAYMSSAMRSAVQNVAKYFPTAIISGRSRDKVYEFVNLSELYYAGSHGMDIMSPAGESLNHEHSRTVSVYEQGKDVNLFQPASEFLPMIDKVLCSLIESTKDIKGVKVEDNKFCISVHYRNVEEKNWTLVAQCVDDVIRTYPKLRLTHGRKVLEIRPVIDWDKGKAVTFLLESLGLNNCEDVLPIYVGDDRTDEDAFKVLRDGPNHGYGILVSAVPKDSNAFYSLRDPSEVMEFLKSLVTWKRSMG
Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.
O64896
Q11CM8
DCUP_CHESB
Uroporphyrinogen decarboxylase
unclassified Chelativorans
MAERKLLEALNGRTVFPPPIWLMRQAGRYLPEYRETRKKAGSFLDLCYNPELAVEVTLQPIRRFGFDAAILFSDILVIPHALGRDLRFEEGAGPLMSPIQANEIPGLDPNLIHNRLQPVYETVRRLRSELSEETALIGFCGAPWTVATYMIAGRGTPDQAPARLFGYRHPKEFSELLDTISAASADYLIRQIDEGADAVQIFDSWAGILDETSFDQWCLRPVAEIVRRVRERHPNVPIIGFPKGAGWLYSRYRQQTGVTALGLDWTVPLSEASRLQAEGPVQGNLDPMRLVAGGQALSKGVEDILSALGGAPFIFNLGHGITPETPIGHVEAMIQQVREGRL
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Q11CM8
Q8AVR4
PDC10_XENLA
Programmed cell death protein 10
Xenopus
MRMTMEEMKNEAETTSMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIITKILEKKSVEVNFTESLLRMAADDVEEYMVERPEPEFQELNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKALNVFISANRLIHQTNLILQTFKTVA
Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.
Q8AVR4
Q92C06
GCST_LISIN
Glycine cleavage system T protein
Listeria
MTELLKTPIHPLYAKYGAKTIDFGGWDLPVQFAGIKAEHEAVRTDAGLFDVSHMGEILVEGPDSTSYLQYLLSNDIEKIKIGKAQYNIMCYETGGTVDDLVVYKKSETEYILVVNAANTEKDYEWMVQNIVGDVTVKNASSEFGQLALQGPNAEKILSKLTDADLSSISFFGFIEDADVAGVKTIISRSGYTGEDGFEIYMQSADAGKVFEAILAEGVAPIGLGARDTLRLEAVLALYGQELSKDITPLEAGLNFAVKLKKEADFIGKQALIKQKEAGLTRKLVGIELIERGIPRHDYPVFLNDKEIGVITSGTQSPTLGTNIGLALIDTAYTELDQELEVGIRNKKVKAKVVQTPFYKRAK
The glycine cleavage system catalyzes the degradation of glycine.
Q92C06
O31149
PT1_LISMO
Phosphotransferase system, enzyme I
Listeria
MAKELKGIAASDGIAIAKAYLLVEPDLSYEKTEVTDVESEVKRFESALEVSRTELSMIREKAAKDLGEDKAQIFDAHLLVLNDPELTGPIEESIKNSKTNAETALQETTDMFIGMFESMDNEYMRERAADIKDVRKRVLSHLLGVTIPNPALIDEEVVVVAADLTPSDTAQLNRNFVKGFVTDIGGRTSHSAIMARSLEIPAVVGTKEVTASVAKNDIVIIDGLEGNVIIHPTEEQIAHYEKIKSDFALQQAEWDKLKNEKTVSKDGVHVELAANIGTPNDLEGVISNGGEAVGLYRTEFLYMGRDNFPTEEEQFEAYKAVVSGMDGKSVVVRTLDIGGDKTLPYLELPEEMNPFLGFRAIRLCFANEELFRTQLRALLRASVYGNLKIMFPMIATVNEFRQARDILLDEKAKLKAAGTEVSDSIELGIMIEIPAAAVLADQFAKEVDFFSIGTNDLIQYTMAADRMNERVSYLYQPYNPSILRLVKMVIDASHKEGKWTGMCGEMAGDQTAVPLLLGLGLDEFSMSASSILKSRSLIKRLDQSEMVKLAEEALNKSTAEEVVELVEKYTAE
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
O31149
B0BQ46
PURT_ACTPJ
Phosphoribosylglycinamide formyltransferase 2
Actinobacillus
MTTIGTPLRPNATKVMMLGSGELGKEVVIELQRLGVEVIAVDRYENAPAQQVAHRAYTISMLDGAALRALAEKEKPDFIVPEVEAIATATLVELEQEGYNVVPTAKATQLTMNREGIRRLAAEELGLKTSPYRFVDNLEDFKQAVAEIGIPCVVKPIMSSSGHGQSVIKSEDQIQQAWDYSQEGGRAGGGRVIVEGFIKFDYEITQLTVRHVNGTSFLAPIGHRQEDGDYRESWQPQAMSDLALKRAQETAERITTALGGRGIFGVELFVCGDEIIFNEVSPRPHDTGMVTMASQELSQFALHARAILGLPISEIYQISPAASKAIVVEGKSNNMTFGNLDKVLEEIGTNIRLFGKGEVNGHRRLGVILARDENTEKALAKAERAYAKLAVQL
Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.
B0BQ46
Q4UMR4
RL6_RICFE
50S ribosomal protein L6
spotted fever group
MSRVGKLPITIPEGVKVGLNDLEVKISGPKGELSKTFKGNIAISLEENKLLVKPLAANKNARAMWGTARSIISNMVTGVKEGFKLKLEINGVGYRAMVKGKYLNLMLAKSHNTKIEIPSDIKIEVPKQNIIILEGTDKEKLGQFASIIIKQRPPEPYKGKGIKFENQFIPRKEGKKN
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q4UMR4
Q9Z6T0
DEGPL_CHLPN
Protease Do
Chlamydia
MITKQLRSWLAVLVGSSLLALPLSGQAVGKKESRVSELPQDVLLKEISGGFSKVATKATPAVVYIESFPKSQAVTHPSPGRRGPYENPFDYFNDEFFNRFFGLPSQREKPQSKEAVRGTGFLVSPDGYIVTNNHVVEDTGKIHVTLHDGQKYPATVIGLDPKTDLAVIKIKSQNLPYLSFGNSDHLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGGPLLNIDGQVIGVNTAIVSGSGGYIGIGFAIPSLMANRIIDQLIRDGQVTRGFLGVTLQPIDAELAACYKLEKVYGALVTDVVKGSPADKAGLKQEDVIIAYNGKEVDSLSMFRNAVSLMNPDTRIVLKVVREGKVIEIPVTVSQAPKEDGMSALQRVGIRVQNLTPETAKKLGIAPETKGILIISVEPGSVAASSGIAPGQLILAVNRQKVSSIEDLNRTLKDSNNENILLMVSQGDVIRFIALKPEE
Might be efficient in the degradation of transiently denatured and unfolded proteins which accumulate in the periplasm following stress conditions.
Q9Z6T0
Q03QU1
DNAK_LEVBA
Heat shock protein 70
Levilactobacillus
MASNKIIGIDLGTTNSAVAVLEGSTPKIIANKEGARTTPSVVAFKDGETQVGEVAKRQAITNPNTISSIKSHMGEAGYKVSVDGKDYTPQQVSAMILQHLKAFAEDYIGDTVEKAVITVPAYFNDAQRQATKDAGKIAGLSVERIINEPTAAALAYGLDKQDKDEKVLVYDLGGGTFDVSVLELGDGVFDVLSTNGDTHLGGDDFDQKIMDWLVAGFKEENGVDLSKDKMALQRLKDAAEKAKKDLSGVTEAQISLPFISAGENGPLHLEKSLSRAKFNELTADLVEKTRIPVQNALKDADLQASDIDVVILNGGSTRIPAVQEAVKSWTGKEPNHSINPDEAVALGAAVQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSKSQVFSTAADNQPAVDIHVLQGERPMAADNKTLGNFQLTDIPAAPRGVPQIQVTFDIDKNGIVNVSAKDMGTNKEQKITIKSSDGLSDEEIEKMMNEAKENEEADKKRKEEVDTKNEVDQLLFQTDKTLKDVKGKVSDDEIKKAEDARDALKKAQEANNLDDMKAKKDDLTKIIQDLSVKLYQQAQSEAGDGNAAGADGATADADKKDDNTVDGDFHEVNDDDKK
Acts as a chaperone.
Q03QU1
B2USG1
ILVC_HELPS
Ketol-acid reductoisomerase type I
Helicobacter
MALPVYYDKDIDLGVIQSLQVGIIGYGAQGEAQALNLRDSKVKVRIGLYQGSLSVPKAKAEGFEVLEVKELVQQSDLIMALLPDELHKEVLEKEVIPFLKEGQIVGFAHGFSVHFNQVVLPKGVGAILVAPKGPGSALREEYLKNRGLYHLIAIEQESSKNNAKAVALSYAKAMGGGRMGVLETSFKEECESDLFGEQAVLCGGLEAIIRMGFETLIKAGYPEELAYFECVHEVKLVADLLHYKGVEGLRKHISNTAEFGAIKNREPMGNLLEKRMQKILKKIQNGSFAKDFLLEKSLNYPRLNTERKALKETKIEQIGEILRAPFNHKK
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
B2USG1
A1SDP0
ARAA_NOCSJ
L-arabinose isomerase
Nocardioides
MTHHPDELEIWFLTGSQHLYGPEVIDQVAEHAARIVAALDASPHLPVRVVSKPVLTETDSIRRALLDATATDSCVGVIAWMHTFSPAKMWITGLDALRKPLLHLHTQANQALPWAEIDMDFMNLNQAAHGDREFASVQTRMGVARKTVTGHVEDPEVARRIGLWARAALGRHALAGMRLARFGDNMRNVAVTEGDKVEAERRFGVSVNTWGVNDLVAVVDEVADADVDKLCEEYADSYDVAAELLPSGERHESLRYGARIELGLRSFLTEGGFTAFTSNFEDLGGLRQLPGLAVQRLMADGYGFGGEGDWKTSVLLRTLKVVADGLPGGTSFMEDYTYHLVPGEERILGAHMLEVCPSIAEGRPSLEIHPLSIGGREDPVRLVFDAAPGPAVLLGLADLGERFRFVGNEVEVVAPTEPLPNLPVARAVWRPAPDLRTSTEAWLMAGGPHHTVLSTALGAEHLDDLAEMTGTELVLVDADTTIRGLAKELRWSAAYHRLAQGL
Catalyzes the conversion of L-arabinose to L-ribulose.
A1SDP0
A6TM76
TRPB_ALKMQ
Tryptophan synthase beta chain
Alkaliphilus
MMKVKELPKKFGKFGGQFVPETLMNALIELERQFIQTKEDDEFQEMYRYYVREYSGRPTPLYYAENLTKKLGGGKIYLKREDLNHTGAHKINNVIGQVLLARKMKKKRIIAETGAGQHGVATATICAMFDLECVVYMGAEDIERQALNVFKMEMLGAEVVSVTSGTATLKDATNEAIRDWVANVKDTYYVIGSVVGPHPYPTMVRDFQRIIGDEVKEQILEKEGRLPNYLVACVGGGSNAMGLFYPFYEDEAVALYGVEAAGLGVETDQHAATITKGSMGVIHGMMTYLLQDEQGQITPVHSISAGLDYPGIGPEHAYYHHTGRANYVAITDEEALEAFQLLTRLEGIIPALESAHAIAYLMKLAPKTKGDDIIVLNLSGRGDKDIHTISKLLGGNRDDK
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
A6TM76
Q0KBK6
MNMC_CUPNH
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Cupriavidus
MPRALEPAEPILSAEGIPYSPRYDDVYHSTEGGLAQAAHVFLGGNGLPQAWAGQRQFVIVETGFGLGLNFLATWQAWRADPQRCGTLHFVSIEKHPFTREGLAQLHAGLDGLQPLAQALQAQWPLALPGLHRLAFDGGRVVLTLALGDIEQMLPRLAAGADAFYLDGFAPARNTEMWSPQVFRGLARLARPGARLATWAAAGFVRRGLKEVGFEVSRAPGFGGKWQMTVASFRPQWKARRHAPPLPAQWAERHAIVIGAGLAGCAVTERLAARGWRVTLFDGHDGPARQTSAHRAAAMHAHLSADDSLLSRLSRTGNQYALRAWAELAEAGHAVGWHGCGVLQIGEDEAEGEAQRAALAAMRLPEGFVRWMSAEEAAAAHHAGVPRGGLWFPQGGWVAPPDICSAQLAQAGAAVTARFGCRVAAIARVDGQWQALGQDGEVLASAPVLVLANAHEAQQLLPQQHWTMRRVRGQLTTLASAQVDALGGWPDCVVTGAGYLLPRTADGAGRVGSSYDADEGPLVEQPAVHAANLARLSGMLPRQADAVAAIDPATLSGYVGVRTVTHNRLPLVGQVPDEAAALAQAASLRGAHLRDLPRMPGLYAALAYGSRGLTWAALGAELLASQIEGEPLPLESDLADAMDPARLLLRALRHGHTG
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
Q0KBK6
Q5JHS5
PAN_THEKO
Proteasome regulatory particle
Thermococcus
MSIENTDVHPEGYDDYVTFLKRRIRQLELQVRTLEADKERLERELSRLRMEMSRLRQPPAFAGNVIEVLDDERAIVQNYNGPRFVVRIAPWIERDKLKPGARVALDQRTMAIVELLPSEKDPSVLGFEVIERPKVTYNDIGGLEKQLQELREAIELPLKHPELFEQVGIEPPKGVLLYGPPGCGKTLMAKAVANHVNATFIRVVGSELVRKFIGEGARLVHELFELAKEKAPTIIFIDEIDAIGAKRMDETTGGEREVNRTLMQLLAEMDGFDPRGNVKVIAATNRPDILDPALLRPGRFDRLIEVPLPDYQGRLEILKVHTRKMNLKGVDLRVIAEITEGASGADLKAIATEAGMFAIRDRRTYVTQDDFLKAVDKVIGSEKRLAQQIAMHEVMYG
ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.
Q5JHS5
A9N514
ULAF_SALPB
Phosphoribulose isomerase
Salmonella
MQKLKQQVFDANMDLPRYGLVTFTWGNVSAIDRERGLVVIKPSGVAYETMKVDDMVVVDMDGKVVEGRYRPSSDTATHLALYQRYPSLGGVVHTHSTHATAWAQAGMAIPALGTTHADYFFGDIPCTRALSEEEVQGEYELNTGKVIIETLGEVEPLHTPGIVVYQHGPFAWGKDAHDAVHNAVVMEEVARMAWIARGINPALNPIDDYLMNKHFMRKHGPNAYYGQK
Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization.
A9N514
Q7VKU5
DUSC_HAEDU
tRNA-dihydrouridine synthase C
Haemophilus
MIKSIPRIMLAPMQGVLDPFMRKLLTAYNDYDLCVSEFVRVVDQRLPKKTFYRLAPELLQGGLTDSGTPIRVQLLGQYPQWLAENAQLAIELGSYGIDFNCGCPSKTVNGSHGGAALLKDPELIYCATKAIREAVPKAQPVSVKMRLGWDCASQCFEIADAIQQAGADEITVHGRTKQDGYRAERINWQAIGQIQQRLNIPVIANGEILDFNSAQKCREITACCGLMIGRGALNTPNLSKVIKYNVAKMAWSEVLQLLYEYVNMPNERDSGFYHVARIKQWLHYLDKAYPEAVDLFQIVKTEHSYDGVKAHIEKAVGRNEKTNFQ
Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.
Q7VKU5
C0R4Y2
NUOB_WOLWR
NDH-1 subunit B
unclassified Wolbachia
MTNQILSNDDWGRYKKEGFLVTKFGDLTDYVMNWARSGSLWPMTFGLACCAVEMMHTASSRYDLDRYGIMFRASPRQSDVMIVAGTLTNKMAAALRKVYDQMADPKYVISMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTAEALLYGMLCLQNKIKRTRNG
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
C0R4Y2
O13924
HASP_SCHPO
Serine/threonine-protein kinase haspin homolog hrk1
Schizosaccharomyces
MESRSKVKTYGKNRRYINKDIEIWASLDERPCALKPRNIENFNNQERSDLEHIHSKPKKDSLLSWNILLKKGSYKENELLAKRNQNLVPTVIIPASPRDNASKSVVSKKEVVNLSSSVALSGKPANNSKLDPLHRLLQIVAQEDALPFSQFVKSQTFEIQKIGEASYSEVYQASNADDVPVVWKVIPFGEDGQAQYADVLNEVQISQWIKVDGFANLHQVVVVKGTYPSLLLEEWDRYLMQNGSENDRPDSYSSTQLYCVLCLDHSGTDLEHFELRSWRECWSVFYETLKILSLVETRYEFEHRDLHWGNILIRKADRSEEEVSFLLNEISLDDIESVDFPGSQDKADDFDNILQVTLIDFTLARASYSQGIISYNEFNDPDLFNGVDDYQFDIYRLMSRVTKGRWAQFFPITNVLWLHYLIHQLLHKKNLSSPLTETETLMRSRLKQIFRLIDPVKTMQFQQAEDSIRSKSTVTSATSLLNWVRQKY
Serine/threonine haspin-like protein kinase involved in cell cycle regulation. Acts in chromosomal passenger complex (CPC) targeting to centromeres by phosphorylating histone H3 at 'Thr3' (H3T3ph).
O13924
B1IAU3
RLMN_STRPI
tRNA m2A37 methyltransferase
Streptococcus
MKPSIHSLTHQTMQEWVLEQGEKKFRADQIWEWLYRKRVQSFEEMTNLSKDLIAKLNDQFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQHYGLSVCVTTQVGCNIGCTFCASGLIKKQRDLNNGEIVAQIMLVQKYFDERGQDERVSHIVVMGIGEPFDNYNNVLNFFRTINDDKGMAIGARHITVSTLGLAHKIRDFADEGVQVNLAVSLHAPNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDGVEQALELAELLKNIKKLSYVNLISYNPVSEHDQYSRSPKERVLAFYDTLKKKGGNCVVRQEHGTDIDAACGQLRSNTMKRDRQKAVAAVNP
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
B1IAU3
C3L062
THIM1_CLOB6
4-methyl-5-beta-hydroxyethylthiazole kinase 1
Clostridium
MENKNVIQKMREKTPLIHCITNYVTINDCANILLSFGASPAMCEAYDEVYDFVSISSALYINLGTLTKEQETAAVLASISAKNHNVPVVIDPVGCPAIKRKVEVINRMAEVGRIDIIKGNIGEIKFLAGMDSETRGVDSLDNGENALDACTQLAKKYNCIVAATGEKDFVSDGKRGSVIKNGTEMLTKVTGAGCMLGALCAATCANFEDKLVSTTAAILSMNIAGEKAYEKAQLPGSFRIALIDNIYMISDEEIWERGNVEWK
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
C3L062
A6TKT6
HIS6_ALKMQ
ImGP synthase subunit HisF
Alkaliphilus
MITKRIIPCLDVRKGRVVKGVNFVDIKDAGDPVALARAYNDQGADEIVFLDITASHEERYILLDVVKKTSEEIFIPLTVGGGIRTVEDMRQIIKSGADKVSINSSAVKNPSMITDCARQFGSQAVVIAMDVKRGADGRYEVYVRGGREKTGLEAVDWARRVAQLGAGEILLTSMDRDGTKSGYDLEITKRISQAVNIPVIASGGAGSVQDFADAFIEGQADAALAASLFHYNEVSIPRLKQSLHEMDISMRR
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
A6TKT6
Q5NQ50
RL6_ZYMMO
50S ribosomal protein L6
Zymomonas
MSRIGKKPVAIPTGVTANIADGVLSVKGPKGELSMPLSSEVTYSLEDGQLSVQPVNDTKRARSFWGMQRTLVQNLIDGVTQGYSKTLQITGVGYRAASQGKTLKLQLGYSHDIDFAIPEGITIQTPEPTTVNISGIDKQKVGQVAAEIRRWRRPEPYKGKGIKYAGEFIFRKEGKKK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q5NQ50
Q64687
SIA8A_MOUSE
Sialyltransferase St8Sia I
Mus
MSPCGRALHTSRGAMAMLARKFPRTRLPVGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLAQRTAWRTNQTSASLFRRQMEDCCDPAHLFAMTKMNSPMGKSLWYDGELLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKMSGCGRQIDEANFVMRCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVGANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHAMPEEFLQLWYLHKIGALRMQLDPCEEPSPQPTS
Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid . Can catalyze the addition of a second alpha-2,8- sialic acid to GD3 to form GT3 . Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively .
Q64687
Q65SS8
NRDR_MANSM
Transcriptional repressor NrdR
Basfia
MHCPFCSTEETKVIDSRLVSDGYQVRRRRECTKCHERFTTFETAELVVPKIIKNNGMREPFNEDKLRRGIQHALEKRPVSADDVEKAISHITHQLRATGEREVPSKLVGSLVMEELKKLDKVAYIRFASVYLSFENINEFSNEIEKLKD
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
Q65SS8
Q3ARQ5
COBT_CHLCH
N(1)-alpha-phosphoribosyltransferase
Chlorobium
MKEKLETLLAAIQPADQTLRQAIQAHLDDLTKPQGSLGRLEEIAQQYILATGQIHPSLPKKKICCFAGDHGVAAEGVSAFPAEVTPQMVYNMLHGGAAINVLSRHVGAELSVVDVGVNHDFADAPNLVQCKVKRGSANMAVGAAMSETETLQAILAGAELAFQAADAGYGLLGTGEMGIANTTPATALYAVLLNLPVEAITGRGTGIDDARLHHKIAVIERAIAVNAERCATPFGTLAALGGFEIAAITGFILGAAARRIPVVVDGFISSSGALVAMKMVPSVVDYLFFSHLSAEQGHGAVMEALGVRPMLSLDLRLGEGTGAALAMQLVDAALKIYNEMATFSGAQVSEKIEG
Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).
Q3ARQ5
Q43309
1A14_ARATH
S-adenosyl-L-methionine methylthioadenosine-lyase 4
Arabidopsis
MVQLSRKATCNSHGQVSSYFLGWEEYEKNPYDVTKNPQGIIQMGLAENQLCFDLLESWLAQNTDAACFKRDGQSVFRELALFQDYHGLSSFKNAFADFMSENRGNRVSFDSNNLVLTAGATSANETLMFCLADPGDAFLLPTPYYPGFDRDLKWRTGVEIVPIQSSSTNGFRITKLALEEAYEQAKKLDLNVKGILITNPSNPLGTTTTQTELNILFDFITKNKNIHLVSDEIYSGTVFNSSEFISVMEILKNNQLENTDVLNRVHIVCSLSKDLGLPGFRVGAIYSNDKDVISAATKMSSFGLVSSQTQYLLSSLLSDKKFTKNYLRENQKRLKNRQRKLVLGLEAIGIKCLKSNAGLFCWVDMRPLLRSKTFEAEMDLWKKIVYEVKLNISPGSSCHCEEPGWFRVCFANMIDETLKLALKRLKMLVDDENSSRRCQKSKSERLNGSRKKTMSNVSNWVFRLSFHDREAEER
1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.
Q43309
B0U659
FTSB_XYLFM
Cell division protein FtsB
Xylella
MRNWRWLLLVLAALLAWLQHRFWFGPGNSGEVRMLQVQIVQQHQENERLRQRNASLAAEVKNLKDGDAAIEERARSELGMIKPGEIFYRVVEDIPAPLPNDTSADHGVDLSQPRREKR
Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.
B0U659
Q9EST2
HNMT_CAVPO
Histamine N-methyltransferase
Cavia
MASSMRSLFSDHGRYFEAFRRFLNNSTEYQCMREFMDKQLPGIIARIGGSKSEIKVLSIGGGAGEMDLHILSKVKAQYPGVHIINEVVEPSAEQITKYKELVAKTSNLENIKFAWHKETSSEYQNRVMEQKEIQKWDFIHMIQMLYYVDDIPATLKFFHSLLATNAKILIILVSGKSGWLKFWKKYRSRLPQNDLCQYVTSFDIIQMLDSLGIKYQCYDLLSTMDITDCFIDGNENGELLWDFLTETCNFLTTAPPDLRAEIMKDLQGPEFIVRKEGKILFDNSLSFITIEA
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Q9EST2
A9B496
DNAA_HERA2
Chromosomal replication initiator protein DnaA
Herpetosiphon
MDTKQIWFTTLGTLQNQILRYDYDTWLKTTALVSVANDLAVIGAPNVTTKQVIEDRFMSVLRRALGEVLGYQVNVRVIISSATPAPSEPVAVTPSEPSPTTEVAEPSFASFNQAAPMLNQLPLGDPNRSSVLNPRYTFSSFIVGTSNRLAHAACMAVAEHPAQAYNPLFLYGGVGLGKTHLLQAIGNYALDRNPEVNVLYVSSEKFTNDLINAIRRQQTEEFRIRYRNIDILLIDDIQFIAGKEGTQEEFFHTFNTLHGAGKQIVLSSDRPPKAILTLEERLRSRFEWGLIVDVQNPDLETRTAILRAKGETLQVPVSSEVIDFLAQRIQSNIRELEGCLNRVIAYANLNRTPVTVEVASAALADLLDTSRRKRVTADDIFREVSQHYGIDQRAIRGRGRSRNVVLPRQVVMYLLREETDASLVEIGELLGGRDHTTVMHGYNKITDDLTSDARLRNDITSLRQRLYGENAR
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
A9B496
P51142
DVL2_XENLA
Xdsh
Xenopus
MAETKVIYHLDEEETPYLVKVPVPATDIRLRDFKAALGRGHAKYFFKAMDQDFGVVKEEISDDNAKLPCFNDRVVSWLASSEGSQPDSAPPAPATEVRPEPPPPVPPPIPPPPAERTSGIGDSRPPSFHPNVSGSTEQLDQDNESVISMRRDRVRRRESSEQAGVGRGVNGRTERHLSGYESSSTLLTSEIETSICDSEEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDINFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQGYFTLPRNEPIHPIDPAAWVSHSAALSGSFPVYPGSASMSSMTSSTSVTETELSHALPPVSLFSLSVHTDLASVVKVMASPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFQDRREARKFASNLLKAGFIRHTVNKITFSEQCYYIFGDLTGCENYMTNLSLNDNDGSSGASDQDTLAPLPLPGASPWPLLPTFSYQYQAPHPYSTQPPAYHELSSYSYGMGSAGSQHSEGSRSSGSNRSDGGRGMQKDDRSGVAGVGGGDSKSGSGSESEYSTRSSIRRVGGGEAGPPSERSTSSRLPPHHPPSVHSYAAPGVPLSYNPMMLMMMPPPPLPPPGVCPPNSSVPPGAPPLVRDLASVPPELTATRQSFHMAMGNPSEFFVDVM
Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia.
P51142
A6WKM0
ERPA_SHEB8
Iron-sulfur cluster insertion protein ErpA
Shewanella
MTDQADTAMPIQFTDAAAAKVKGLLEEEQNPALKLRVYVTGGGCSGFQYGFTFDEKVNDGDFTIEKQGVLLVVDPMSLQYLVGGEVDYTSGLEGSRFFVKNPNATTTCGCGASFSV
Required for insertion of 4Fe-4S clusters for at least IspG.
A6WKM0
Q861R7
KANL2_CAPHI
Non-specific lethal 2 homolog
Capra
MNRIRIHVLPTNRGRITPVPRSQEPLSCSFTHRPCSQPRLEGQEFCIKHILEDKNAPFKQCSYISTKNGKRCPSAAPKPEKKDGVSFCAEHARRNALALHAQMKKTNPGPVGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGEQEPITVDQTWRGDPDSEADSIDRDQEDPLKHAGVYTAEEVALIMREKLIRLQSLDIDQVKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLARERENLKRLKCLRRYRQRYGVKALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNRVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDSMQCPPSPLLFDPSLTLEDHPVKEIAEGPVDILGQMQMAGDGCRSQGPRNSEKAPAPLSQSGIATANGKPEPTSVS
As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.
Q861R7
B7KU78
DNLJ_METC4
Polydeoxyribonucleotide synthase [NAD(+)]
Methylorubrum
MPSTPLSATVEALSEDAAQARHAELSRAIERANQLYYNEDAPELTDAEYDALRQELEAIEARFPALTGTTEASAGVGAKPSEKFAKVRHAVPMLSLGNAFADEDVDEFVARVRRFLNLPAEEAVAFTAEPKIDGLSLSLRYEAGRLVTAATRGDGEVGENVTANALTVDDIPETLSGEGIPEVLEVRGEIYLSHEDFAAINARQEAAGKPLFANPRNAAAGSLRQLDPAITASRPLRFFAYAWGEVSEPFTDTQSAVLERFRGWGLPVNPRTKLCRSAEEMIAHYRAIEAERAGLGYDIDGVVYKVDDLGFQRRLGFVSRAPRWALAHKFAAQEAITELLAIDINVGRTGSLNPLARLKPVTVGGVVVSNATLHNEGYVQGVGADGEPIREGRDIRVGDTVIVVRAGDVIPKVRDVVIEKRPADAVPYVFPDTCPACGSRAVRELNPRTKKLDAIRRCTGGLICPAQGVERLKHFVSRNGLDLEGFGQTYIEVLFEAGLVKQPADLFRLEFEPLKAAIVARREALSAQRRTEGEPAPKKPTKKKGEEEDKAIKNLLASLDARRTIPLNRFLFALGIPQIGESTAKALAKRFPDMPALMAALAAATREQAGRDWLELSALPRIGPGTRDRLFETLDPLPGEAMQDLSLGARLRGRLTPSQREAVLAHYGSEAEADAALERAASQRPGDAYRLFADDGEIGPVATDSLIQFFSEPHNDAAVRALLEEVGTEPLAATTSAAAFAGKTVVFTGSLEKMTRSEAKATAERLGAKVSGSVSAKTDLVVAGPGAGSKLKDAEKHGVKVVSEDDWLAMLAEA
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
B7KU78
A1W445
HIS3_ACISJ
Phosphoribosyl-AMP cyclohydrolase
unclassified Acidovorax
MDTMNWLDQVKWDAQGLVPVIAQEAATGDVLMFAWMNREALAKTAELGRAVYYSRSRGKLWFKGEESGHVQQVHDIRLDCDSDVVLLKVTQLGHEPGIACHTGRHSCFFNALQNGAWQAVDPVLKDPESIYK
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
A1W445
Q0SN27
RL23_BORAP
50S ribosomal protein L23
Borreliella
MKAYDIIVSPMLTEKTNTQRESINVYVFKVNKRANKKEVGAAIKELFNVTPVSCNLLNIKSKAKVVVSRKGYPIGKGKTSSWKKAYVYLKKEDKIDIF
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
Q0SN27
O52338
RS3_MYCGA
30S ribosomal protein S3
Mycoplasma
MGQKVNSNGLRFGINKNWQSRWVAKTNQQTGDWIVQDEKIRNYLFKKFHSAFISNVDIERTQTSIRVFIYASQPGIILGKEAANIKVILLAINKIVGRHIKVDVDVLEVGNPSLSAKIVARELADAIENRTPLRTAMRQALKRVLKAGAKGIKVLVSGRLNGVEIARDKMYIEGNVTLSTLRTDIDYALEEAQMSYGVIGVKVWINRGEIFGKDFYKKQAHIVKPKGSEANHQRRNSNKSKDYRDNKNKQFNKNHQNQQPAKE
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
O52338
Q830Y9
NADE_ENTFA
NH(3)-dependent NAD(+) synthetase
Enterococcus
MTTLQEKIIQELGVLPTIDPKEEVRKSIDFLKAYLTKHPFLKTFVLGISGGQDSTLAGRLAQLAMTEMREETGDMSYQFIAIRLPYGEQADEADAQAALAFIQPDVSLRVDIKPAVDAMVGSLENAGVQISDFNKGNMKARQRMITQYAVAGENAGAVIGTDHAAENVTAFFTKYGDGGADILPLFRLNKRQGKALLKELGAPEALYLKIPTADLEDDKPLVADEVALGVTYDAIDDYLEGKKVSETDQQTIENWYKKGQHKRHLPITIFDDFWK
Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
Q830Y9
P53685
HST1_YEAST
Regulatory protein SIR2 homolog 1
Saccharomyces
MNILLMQRIVSFILVVSQGRYFHVGELTMTMLKRPQEEESDNNATKKLKTRLTYPCILGKDKVTGKFIFPAITKDDVMNARLFLKDNDLKTFLEYFLPVEVNSIYIYFMIKLLGFDVKDKELFMALNSNITSNKERSSAELSSIHAKAEDEDELTDPLEKKHAVKLIKDLQKAINKVLSTRLRLPNFNTIDHFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAHMVLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQILINRDMVTHAEFDLNLLGFCDDVASLVAKKCHWDIPHKKWQDLKKIDYNCTEIDKGTYKIKKQPRKKQQ
NAD-dependent histone deacetylase involved in telomeric silencing. Histone deacetylase proteins act via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Restores silencing at HMR in SIR2 mutants when overexpressed. Required to repress middle sporulation genes during vegetative growth. Acts as a sensor of NAD(+) levels and regulator of NAD(+) biosynthesis. Regulates the gene expression of de novo NAD(+) biosynthesis genes.
P53685
O75578
ITA10_HUMAN
Integrin alpha-10
Homo
MELPFVTHLFLPLVFLTGLCSPFNLDEHHPRLFPGPPEAEFGYSVLQHVGGGQRWMLVGAPWDGPSGDRRGDVYRCPVGGAHNAPCAKGHLGDYQLGNSSHPAVNMHLGMSLLETDGDGGFMACAPLWSRACGSSVFSSGICARVDASFQPQGSLAPTAQRCPTYMDVVIVLDGSNSIYPWSEVQTFLRRLVGKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTKEEVVRAAKNLSRREGRETKTAQAIMVACTEGFSQSHGGRPEAARLLVVVTDGESHDGEELPAALKACEAGRVTRYGIAVLGHYLRRQRDPSSFLREIRTIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEGSHAENESSFGLEMSQIGFSTHRLKDGILFGMVGAYDWGGSVLWLEGGHRLFPPRMALEDEFPPALQNHAAYLGYSVSSMLLRGGRRLFLSGAPRFRHRGKVIAFQLKKDGAVRVAQSLQGEQIGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQQSLLTLQGTLQPEPPQDARFGFAMGALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQSGVRPHPAQRIAAASMPHALSYFGRSVDGRLDLDGDDLVDVAVGAQGAAILLSSRPIVHLTPSLEVTPQAISVVQRDCRRRGQEAVCLTAALCFQVTSRTPGRWDHQFYMRFTASLDEWTAGARAAFDGSGQRLSPRRLRLSVGNVTCEQLHFHVLDTSDYLRPVALTVTFALDNTTKPGPVLNEGSPTSIQKLVPFSKDCGPDNECVTDLVLQVNMDIRGSRKAPFVVRGGRRKVLVSTTLENRKENAYNTSLSLIFSRNLHLASLTPQRESPIKVECAAPSAHARLCSVGHPVFQTGAKVTFLLEFEFSCSSLLSQVFVKLTASSDSLERNGTLQDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIISALLPAVAHGGNYFLSLSQVITNNASCIVQNLTEPPGPPVHPEELQHTNRLNGSNTQCQVVRCHLGQLAKGTEVSVGLLRLVHNEFFRRAKFKSLTVVSTFELGTEEGSVLQLTEASRWSESLLEVVQTRPILISLWILIGSVLGGLLLLALLVFCLWKLGFFAHKKIPEEEKREEKLEQ
Integrin alpha-10/beta-1 is a receptor for collagen.
O75578
Q7NGL0
RF3_GLOVI
Peptide chain release factor 3
Gloeobacter
MSNPTLAAEVGRRRTFAIISHPDAGKTTLTEKLLLYGGAIDMAGSVRARRNQRHATSDWMAMEQQRGISITSTVLQFVYRDCQINLLDTPGHQDFSEDTYRTLAAADNAAMLIDAAKGIEAQTRKLFDVCRMRGIPIFTFINKLDRPGREPLELLDEIEKVLGIDVYPVNWPIGMGDTFRGVFDRLEHTVHLFDRTTGGKKMAPVTVGAIGDERMRVLMDEGTYAQIVEEIELLDGVGVPFDIERVAQGKLTPVFFGSAANNFGVQLFLDAFIRFASRPGTRSANTGVISPVAEDFSGFVFKIQANMDPQHRDRVAFIRVCSGKFEKDMTVHHTRSGKKVRLSRSLKLFGQERETVEEAYAGDIVGVINPGTFAIGDTICLGKPLAFEGIPLFPPEHFATLRNPNPSKYKQFLKGVTQLREEGAVQVLFHQDEAKRDPILAAVGQLQFDVVRFRLESEYHVETILEPLPWTLARWITAKQLEDLETIDWYFDSLGLKDHEGRLVILFKTPWGFQQMSERNPHLQFHEIAPL
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
Q7NGL0
A9MFE4
CEDA_SALAR
Cell division activator CedA
Salmonella
MMKPLRQQNRQIISYIPRVEPAPPEHAIKMDAFRDVWILRGKYVAFVLMGESFQRSPAFSVPESAQRWANQVRQENEIAD
Activates the cell division inhibited by chromosomal DNA over-replication.
A9MFE4
Q6MCT6
RISB_PARUW
6,7-dimethyl-8-ribityllumazine synthase
Candidatus Protochlamydia
MKEYKGKLNISKARIGIVISRFNETITKNLLEGSLDELERYGISTQNLPVAWVPGAFEIPLIAKQMALSGEFDAIICLGAIIRGTTPHFDYVASQSAAGILNVSLEINLPVVFGILTTDTVEQAMERSGVKMGNKGREAVQTAIEMIDLTDQLSLLRNHPHSSTANNTSVCK
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Q6MCT6
Q00873
CYT2_YEAST
Cytochrome c1 heme lyase
Saccharomyces
MMSSDQQGKCPVDEETKKLWLREHGNEAHPGATAPGNQLECSANPQDNDKTPEYHTTVDLSQSREVSTIPRTNSDRNWIYPSEKQFYEAMMKKNWDPNSDDMKVVVPLHNSINERVWNYIKSWEDKQGGEACGGIKLTNFKGDSKKLTPRAWFRSRILHLAKPFDRHDWQIDRCGKTVDYVIDFYSTDLNDANSQQQPLIYLDVRPKLNSFEGFRLRFWKSLGF
Lyase that catalyzes the covalent linking of the heme group to the cytochrome C1 apoprotein to produce the mature functional cytochrome.
Q00873
A8A4U6
KBAZ_ECOHS
D-tagatose-1,6-bisphosphate aldolase subunit KbaZ
Escherichia
MKHLTEMVRQHKAGKTNAIYAVCSAHPLVLEAAIRYASANQTPLLIEATSNQVDQFGGYTGMTPADFRGFVCQLADSLNFPQDALILGGDHLGPNRWQNLPAAQAMANADDLIKSYVAAGFKKIHLDCSMSCQDDPIPLTDDIVAERAARLAKVAEETCLEHFGEADLEYVIGTEVPVPGGAHETLSELAVTTPDAARATLEAHRHAFEKQGLNAIWPRIIALVVQPGVEFDHTNVIDYQPAKASALSQMVENYETLIFEAHSTDYQTPQSLRQLVIDHFAILKVGPALTFALREALFSLAAIEEELVPAKVCSGLRQVLEDVMLDRPEYWQSHYHGDGNARRLARGYSYSDRVRYYWPDSQIDDAFAHLVRNLADSPIPLPLISQYLPLQYVKVRSGELQPTPRELIINHIQDILAQYHTACEGQ
Component of the tagatose-1,6-bisphosphate aldolase KbaYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of KbaY. When expressed alone, KbaZ does not show any aldolase activity.
A8A4U6
Q8ECV2
TRPD_SHEON
Anthranilate phosphoribosyltransferase
Shewanella
MSETSIQPLLDILFQGKALTREQTASLFSVLIQGEMNETVMAGMLMALKIRGETIEEISGAADAMRAAAKPFPYPESSRSQGVIDIVGTGGDGFNTINISTTAAFVAAAAGAKVAKHGNRSVSSKSGSSDLLAQFGIDLTMSPELASHCLEALNLCFLFAPHYHGGVKHAVPVRQTLKTRTLFNVLGPLINPARPEFMLLGVYSAELVTPIARVLQALGTQRAMVVHGSGLDEVALHGSTQVAELKDGEIIEYQLTPADFGVPQAHISELEGGEPAHNALITQQILQGHGCDAHTHAVAINAGCALYLCGLSESVKMGTALALSTIKTGKAYELLHKLATVSSQSQE
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q8ECV2
A0RQM9
RIMO_CAMFF
Ribosome maturation factor RimO
Campylobacter
MPNLYLVSLGCNKNLVDSEIMLGRLSSYNIVDKPNNADVMIVNTCGFIESAKEESVRTILELASYKKENSVLVVTGCLMQRYRDELMKELPEVDIFTGVGDYASIDEMILKKQNLFSPGVYLQKSDTKRVITGSSYHAYIKIAEGCNQKCSFCAIPTFKGKLKSRDINSIIKEVKELTKDGYSDFSFIAQDTSSFLRDAGINDGLIKLIDEVEKIEAVKSARILYLYPTTASMGLIDKIIASPKFVNYFDMPIQHINDDMLKIMRRGSSKERLKELLTKMRVAPKSFLRTGIIIGHPGETGERFDELCDFLTEFKFDRISAFAYSKEEGTLAYEMEQIPSKTITKRLNTIEKIIKKQIEGSFKSLVGEVIKVQINGSSSEGEMFFGAKSIIWDREIDGEILINDTQIKDPKVGEIYDCKINEFVKDKLIGEIICNS
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
A0RQM9
Q3KI09
Y854_PSEPF
Nucleotide-binding protein Pfl01_0854
Pseudomonas
MRLIIVSGRSGSGKSTALDVLEDNGYYCIDNLPAGLLPELAERALIHTELAQPLVAVSIDARNLPSHLSRFPELLEDVRAKHIQCDVLYLDADEETLLKRFSETRRRHPLSNANRSLAEAIQDESALLGPIADLADLKINTTHLNLYQLRDTIKLRLLNQPEPGTAFLVESFGFKRGMPVDADLVFDVRCLPNPYWKPELRAQSGLDQPVAEYLAAQPEVEEMYQDIYTYLYKWLPRFAASNRAYVTIAIGCTGGHHRSVYLTERLGQALQKTLKNVQVRHRDLS
Displays ATPase and GTPase activities.
Q3KI09
Q8J0N2
SODC_CORMI
Superoxide dismutase [Cu-Zn]
Cordyceps
MVKAVCVLRGDAKVAGTVTFEQESESAPTTITWDITGNDPNAERGFHIHTFGDNTNGCTSAGPHFNPHGKTHGAPTDAARHVGDLGNIKTDGQGNAKGSVQDSHVKLIGPHSVVGRTVVVHGGTDDLGKGGNEESLKTGNAGPRPACGVIGVAN
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Q8J0N2
B7LN84
MUKF_ESCF3
Chromosome partition protein MukF
Escherichia
MSEFSQTVPELVAWARKNDFSISLPVDRLSFLLAVATLNGERLDGEMSEGELVDAFRHVSDAFEQTSETIGVRANNAINDMVRQRLLNRFTSEQAEGNAIYRLTPLGIGITDYYIRQREFSTLRLSMQLSIVAGELKRAADAAEEGGDEFHWHRNVYAPLKYSVAEIFDSIDLTQRLMDEQQQQVKDDIAQLLNKDWRAAISSCELLLSETSGTLRELQDTLEAAGDKLQANLLRIQDATMTHDDLHFVDRLVFDLQSKLDRIISWGQQSIDLWIGYDRHVHKFIRTAIDMDKNRVFAQRLRQSVQTYFDEPWALTYANADRLLDMRDEEMALRDEEVTGELPEDLEYEEFNEIREQLAAIIEEQLAVYKTRQVPLDLGLVVREYLAQYPRARHFDVARIVIDQAVRLGVAQADFTGLPAKWQPINDYGAKVQAHVIDKY
Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.
B7LN84
B4LUA5
EIF3I_DROVI
TRIP-1 homolog
Drosophila
MLQGHERSITQIKYNREGDLLFSSSKDQKPNVWYSLNGERLGTYDGHQGAVWCLDVDWESRKLITGAGDMTTKIWDVEYGTVIASIPTKSSVRTSNFSFSGNQAAYSTDKAMGQNCELFIIDVRNADSSLSEQEPTLRIPMVESKITSMLWGPLDETIITGHDNGNIAIWDIRKGQKVVDSGTDHTAGINDMQLSKDGTMFVTASRDTTAKLFDSESLMCLKTYKTERPVNSAAISPILDHVVLGGGQDAMEVTTTSTKAGKFDSRFFHLIYEEEFARLKGHFGPINSLAFHPDGKSYASGGEDGFVRVQSFDSTYFENIFE
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
B4LUA5
Q39785
CHI2_GOSHI
Endochitinase 2
Gossypium
EQCGRQAGGALCPGGLCCSQFGWCGSTADYCTVPGCQSQCSGSGPAPGPGGLTNLISRETFNQMLLHRNDGACPARGFYTYDAFIAAARSFPAFATTGDQATRKREIAAFLAQTSHETTGGAGWAAPDGPYAWGYCYNRELNPPSSYCASDPNYPCAPGKQYFGRGPMQLSWNYNYGQCGRAIGVDLLNNPDLLSSDPTISFKSAFWFWMTPQSPKPSCHNVIIGAWSPSSSDRAAGRATGYGVITNIINGGLECGKGWNAQVEDRIGFYKRYCDILGVSYGNNLDCYNQSPFGNGVSVDSM
Defense against chitin-containing fungal pathogens.
Q39785
Q61754
K1B24_MOUSE
Tissue kallikrein 24
null
MWFLILFLALSLGGIDAAPPVQSRVVGGFKCEKNSQPWHVAVFRYNKYICGGVLLNPNWVLTAAHCYGNATSQYNVWLGKNKLFQREPSAQHRWVSKSFPHPDYNMSLLNDDIPQPKDKSNDLMLLRLSEPADITDAVKPIDLPTEEPKLGSTCLASGWGSITPTKWQKPNDLQCVFIKLLPNENCTKPYLHKVTDVMLCAGEMGGGKDTCAGDSGGPLICDGILHGITSWGPVPCGKPNAPAIYTKLIKFASWIKDTMAKNP
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.
Q61754
P57314
MRAY_BUCAI
UDP-MurNAc-pentapeptide phosphotransferase
Buchnera
MLIFFNKYLHINLNILSYIPYRAIFSLLTSFFINLYIGPYFIYYFKKLQTYQIIRNNGPKTHYSKKNTPTMGGIFIIFSILFSTILYCNLSNIYIWYVISILIGYGLIGFIDDYKKIKYKNSQGLKLKWKYFFLSIIAFIFICMIKINNKDIISTELIIPFCIKNDFEINYLYIFLSYFVLVGTSNAVNLTDGLDGLAIMPVIFLTCGLTLISLFSDNINISHYLHVQYVKNSTELAILCMAIVGSGLGFLWFNSYPAKVFMGDVGSLALGGSLGAIAILLHQELLLIIMGGIFVFETISVILQIISFKIRKKRIFQMAPVHHHYEVKGILEPLIIVRFWIVSLILLLISLISLKVC
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
P57314
A6RC73
NOP16_AJECN
Nucleolar protein 16
unclassified Histoplasma
MGRILQKKKNRSGAPRVKQKSNRLKNGNKKINVLGNAIIAQNWDKKLTLTQNYRRLGLASQLNAPTGGAENKPDDPSNGRQEADSLHLLPSLASVKMIKPAEMRVERDPATGKILRVIHPENETEEVEIAGRKHRRANPLEDPLNEVGDDVLNNTALRIHGSSTSSAVVQALERQAALEEEALKKKQPRQQSKREEEWLERLVAKHGDNIIAMVRDTRLNPMQQTEGDIKRRLKKWREKRGNV
Involved in the biogenesis of the 60S ribosomal subunit.
A6RC73
Q9I4P4
FLGJ_PSEAE
Muramidase FlgJ
Pseudomonas
MDSRLLSGIGAGPDSGSYTDLNRLNQLKVGKDRDGEANIRKVAQEFESLFLNEMLKSMRSANEALGDGNFMNSQTTKQYQDMYDQQLSVSLSKNAGGIGLADVLVRQLSKMKQGSRGNGENPFARVAENGAGRWPSNPSAQAGKALPMPEAGRDDSKLLNQRRLALPGKLAERMLAGIVPSASPAASQMQSLGQDSYLPAQSYPAASRRGFSTDGVDSQGSRRIAQPPLARGKSMFASADEFIATMLPMAQKAAERIGVDARYLVAQAALETGWGKSIIRQQDGGSSHNLFGIKTGSRWDGASARALTTEYEGGKAVKEIAAFRSYSSFEQSFHDYVSFLQGNDRYQNALDSAANPERFMQELQRAGYATDPQYARKVAQIARQMQTYQAVAAAGTPPLG
Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space.
Q9I4P4
Q1GCM3
NTPP_RUEST
Nucleotide pyrophosphatase
unclassified Ruegeria
MSTHILLASGSEIRAKLLRQAGVDFRVEVARVDEDAIKTALEADGASPRDIADTLAEAKARKVSGKFPEEMVLGCDQVLDFEGTLLSKPKDKNQALQQLKAMRGKRHMLLSAAVIYCDAKPLWRHVGQVRLVMRMASDAYLESYVERNWESIRHAVGAYKLEEEGVRLFTTIDGSYFNVLGLPMLELMNYLGLQGIIEQ
Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
Q1GCM3
A1SMA5
DNLJ_NOCSJ
Polydeoxyribonucleotide synthase [NAD(+)]
Nocardioides
MKRNGFVPSNSVGRRGIPSNSTSSAIASAGGAVVWTGAGAGRVRARPEQVSVGPGTMSCVTDPREEHRLIAEEIEEARWRYYVLDSPTIDDADFDRRMRRLEALEEEFPELRTPDSPTQTVGGAVSTDFTSHPHLRRMESLDNAFSVEEVEAWYARLRRDGVEDPALLCELKVDGLAINLLYEEGRLVRALTRGDGTTGEDVTSNVKTITSVPHRLTGTDEFPVPALVEVRGEVFLPVEAFERLNESLLEAGKAPFANPRNSAAGSLRQKDPRITASRALGMVCHGIGERRGFEPQAQSHAYDALAAWGLPTSDQVRVVSTLKGVEGYIENAGARRHTIVPYEIDGVVVKVDDVALQRRLGSTSRAPRWAIAFKYPPEEVNAKLLEIRVNVGRTGRVTPYAVMEPTKVAGSTVENATLHNFYEVERKDVRPGGPGDPGDTVILRKAGDVIPEILGPVLALRPEGLQPWVPPTTCPSCGTPLVEQKEGDKDRRCPNHEKCPGQLRERVFFVASRNAFDIEGLGYEAAVALLDAEVIANEGDVFDLDAAALLRAPLFTRAPKKDEDGPQLSANGQRLLDNLDKAKQVPLWRVLVALSIRHVGPKAGRALATEFGSMAAIRAATEEQLAAAEGVGPTIAEAVIEWFKEPWHVEIVDKWERAGVTMADERDESTPRTLAGLTVVVTGSLVDFSRDSAKEAILSRGGKAAGSVSKKTDYVVVGENAGSKADKAEQLGVPVLDEAGFKTLLDGGPAAL
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
A1SMA5