accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
A6LP60
DAPH_THEM4
Tetrahydrodipicolinate N-acetyltransferase
Thermosipho
MNTQEIINLIANSKKRTIAKAYVSGNLKNIKLENVEFVGNELFGVLFGDLKDIENTINKNDIKNYKIEILAKNSAIPLADIKKYNARIEPGAIIRDMVEIGDGAVIMMGAVINIGAVIGEKTMIDMNTVIGGRAIIGKNCHIGAGSVIAGVIEPPSAKPVMIKDNVMVGANAVILEGVEIGEHSVIAAGAVVIEDIPPYSVVAGVPAKVIKKVDKKTESKTQIIDSLRNLK
Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.
A6LP60
Q2MGI2
RF2_STRPN
Peptide chain release factor 2
Streptococcus
MDISVIRQKIDANREKLASFRGSLDLEGLEEEIAILENKMTEPDFWNDNIAAQKTSQELNELKNTYNTFHKMEELQDEVEILLDFLAEDESVHDELVAQLAELDKIMTSYEMTLLLSEPYDHNNAILEIHPGSGGTEAQDWGDMLLRMYTRYGNAKGFKVEVLDYQAGDEAGIKSVTLSFEGPNAYGLLKSEMGVHRLVRISPFDSAKRRHTSFTSVEVMPELDDTIEVEIREDDIKMDTFRSGGAGGQNVNKVSTGVRLTHIPTGIVVQSTVDRTQYGNRDRAMKMLQAKLYQMEQDKKAAEVDSLKGEKKEITWGSQIRSYVFTPYTMVKDHRTSFEVAQVDKVMDGDLDGFIDAYLKWRIS
Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.
Q2MGI2
C3MIE4
BETA_SINFN
Betaine aldehyde dehydrogenase
Sinorhizobium
MQADYIIIGSGSAGSALAHRLSEDSRNSVIVLEFGGTDIGPFIQMPAALAWPMSMNRYNWGYLSEPEPHLNNRRITAPRGKVIGGSSSINGMVYVRGHAEDFDRWEQLGAKGWAYADVLPYFKRMEHSHGGEDGWRGTDGPLHVQRGPVKNPLFHAFVEAGKQAGFEMTDDYNGSKQEGFGLMEQTTWRGRRWSAASAYLKPALKRPNVQLIRCFARKIVIENGRATGVEIERGGRIEVVKANREVIVSASSFNSPKLLMLSGIGPAAHLKDLGIDVKVDRPGVGQNLQDHMEFYFQQISTKPVSLYSWLPWFWQGVAGAQWLFFKSGLGISNQFEACAFLRSAPGVKQPDIQYHFLPVAIRYDGKAAANTHGFQVHVGYNLSKSRGSVTLRASDPKADPVIRFNYMSHPEDWEKFRHCVRLTREIFGQKAFDQYRGPEIQPGERVQTDEEIDAFLREHLESAYHPCGTCKMGSKDDPMAVVDPETRVIGVDGLRVADSSIFPHVTYGNLNAPSIMTGEKAADHILGKQPLARSNQEPWINPRWAISDR
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
C3MIE4
P27675
GLNQ_GEOSE
Glutamine transport ATP-binding protein GlnQ
Geobacillus
MIYFHQVNKYYGDFHVLKDINLTIHQGEVVVIIGPSGSGKSTLVRCINRLETISSGELIVDNVKVNDKHIDINQLRRNIGMVFQHFNLYPHMTVLQNITLAPMKVLRIPEKEAKETAMYYLEKVGIPDKANAYPSELSGGQQQRVAIARGLAMKPKIMLFDEPTSALDPETIGEVLDVMKQLAKEGMTMVVVTHEMGFAREVADRIVFMDQGRILEEAPPEEFFSNPKEERAKVFLSRILNH
Part of the binding-protein-dependent transport system for glutamine. Probably responsible for energy coupling to the transport system.
P27675
B4ECP3
DAPE_BURCJ
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Burkholderia cepacia complex
MSATLALTEQLIARASVTPDDQHCQQIMTERLAALGFECETIASHGVTNLWAVKRGTDGRDGKLLAFAGHTDVVPTGPLEQWTSPPFIPAHRDGKLYGRGAADMKTSLAAFVVASEEFVAAHPDHRGAIAFLITSDEEGPATDGTVKVVELLQARGERLDYCIVGEPTSTTELGDVVKNGRRGSMSGELVVKGVQGHIAYPHLAKNPIHLLAPALAELAAEQWDAGNEYFPPTTWQVSNLHAGTGATNVIPGHADLLFNFRFSTASTVEGLQARVHAILDKHGLEYTLKWSVSGLPFLTPRGELSGALEHAIRTETGITTELSTTGGTSDGRFIARICPQVIEFGPPNGSIHKIDEHIEVRFVDPLKNVYRRVLEQLIA
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
B4ECP3
P48101
CHLI_CYAPA
Mg-protoporphyrin IX chelatase
Cyanophora
MKNNNRPIFPFTAIVGQEEMKLALLLNIVDPKIGGVMIMGDRGTGKSTTIRALADLLPEIDIVANDPFNSHPTDIELMSDNVRQLKENGEEISLIQKKVPMIDLPLGATEDRVCGTIDIEKALTEGVKAFEPGLLAQANRGILYVDEVNLLDDHLVDILLDSAASGWNTVEREGISIRHPARFVLVGSGNPEEGELRPQLLDRFGMHAEIRTVKDPTLRVQIVEERSEFDRSPEDFLQEYKLQQEVLRQRIINAQQQLNNVQLNYEIKVKISQVCSELDVDGLRGDIVTNRAAKALAAFEGRDEVTVDDVLRIITLCLRHRLRKDPLEEIDSGQKVEKVFQRIFSNL
Involved in chlorophyll biosynthesis; introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX.
P48101
Q82SJ7
PDXJ_NITEU
Pyridoxine 5'-phosphate synthase
Nitrosomonas
MIALGVNIDHVATVRQARGTTYPSPVEAALVAEVAGADAITLHLREDRRHIQENDVVILRDRLKTRMNLESAVTEEMIAFACRIKPHDICLVPERREELTTEGGLDVIRHFQQVSVACKRLAEAGIRVSLFVDAQAGQIDAAVEAGAPVIELHTGRYADAATPEMQQVELETIRTMAAYAFGRGLQVNAGHGLHYENTVQIAAIPELSELNIGHAIVARALFVGFAEAVREMKALLQQARA
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
Q82SJ7
Q1PFB9
AGC17_ARATH
AGC serine/threonine-protein kinase subfamily 1 member 7
Arabidopsis
MLTKPGKKLDSSESTHHTTSSNYPPLDIVHQTPQPRKEMQQKPLFDPKKMDNLIKPEPAGFTNHHRPNPSPKIPSSPGSNMTESQSNLNTKPNNNNSNNNSNMSSRSNSIESTSSNPSKPHTGGDIRWDAVNTLTSKGVQLGISDFRLLKRLGYGDIGSVYLVELRGTITYFAMKVMDKASLASRNKLLRAQTEREILSQLDHPFLPTLYSHFETDKFYCLVMEFCGGGNLYSLRQKQPNKCFTEDAARFFASEVLLALEYLHMLGIVYRDLKPENVLVRDDGHIMLSDFDLSLRCSVSPTLVKSSSVHAAGGGSGSSRPVGLIDEDAAVQGCIQPSTFFPRILQSSKKNRKAKSDFGLFVNGSMPELMAEPTNVKSMSFVGTHEYLAPEIIRGEGHGSAVDWWTFGIFIYELLYGATPFKGQGNRATLHNVIGQALRFPEVPHVSSAARDLIKGLLVKEPQKRIAYKRGATEIKQHPFFEGVNWALIRSATPPHVPEPVDFSCYASKDKESMAAVDGGGKKNNNGAGGGCSTGGGDNKPNGDCNDPDYIDFEYF
Functions redudantly with AGC1-5 as signaling component in the pollen tube. Required for polarized growth of pollen tubes.
Q1PFB9
Q0W1X7
RL24_METAR
50S ribosomal protein L24
Methanocella
MCEVCVMVTSSQPRKQRKFRYEAPQHVRSNFINARLSEELSKKYGRTARVIVGDTVKVMRGDAAGTEGKVREIDVKREKVVVEGVSVARADGKEEARPIHPSNLMITKLVLDDPKRVASLERK
Located at the polypeptide exit tunnel on the outside of the subunit.
Q0W1X7
Q07GW8
HTPG_RHOP5
High temperature protein G
Rhodopseudomonas
MTTTDTAPQTQPFQAEVAELLNLMVHSVYSETEIFLRELISNGSDALDKLRYEAISKPDLMEAGGTPKIQIVPKKAPDTLSVIDNGIGMDRQELIDNLGTIAKSGTKSFLTKLTEAKDGSNLIGQFGVGFYAAFMVADRIVVTSRRAGSTEAWTWTSSGGAGFEIAPASAEEAERIVRGTEIVLHLKPEAAKYLEAYQIERIVSAYSDNIQFPIELVPEEGEARQINSASALWQRSKSELAAEDYKQAYKSIANAFDDPAMTLHYRAEGRYSYAVMLFAPSTKPFDLFEPQRKGHVKLYVRRVFITDDADLLPAYLRFIRGVIDSEDLPLNLSREMLQNNPQLVQIRKAVTGKVIGELESLGEKDPENFAKIWDAFGPVIKEGIWEDYERREKLLALSRFTTTKGDNRTLKNYVEDLRDNQTEIYYLVGDSLERLKSNPKLESAAARGIEVLLLTDPVDAFWTSAPLDFGGKPLKSLSQGDVNFDLIPTTDEAKDEQPKPETDEALVIATIKDALGERVSDVRASQRLTASASCLIAGGQGPDRALERMLAQQNRGGASKPILEINLRHPLVAAIGRPGNADAADLSLLLLEQAQILDGELPEDPAGFAGRINRLVLRAL
Molecular chaperone. Has ATPase activity.
Q07GW8
Q7LZQ4
PA2A_GLOUS
Phosphatidylcholine 2-acylhydrolase
Gloydius
SLIQFETLIMKVAKKSGMFWYSNYGCYCGWGGQGRPQDATDRCCFVHDCCYGKVTGCDPKMDVYSFSEENGDIVCGGDDPCKKEICECDRAAAICFRDNLNTYNDKKYWAFGAKNCPQEESEPC
Snake venom phospholipase A2 (PLA2) that inhibits ADP-induced platelet aggregation. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Q7LZQ4
Q8RDQ0
MRAY_FUSNN
UDP-MurNAc-pentapeptide phosphotransferase
Fusobacterium
MLYFLAEHLAKLEFLKSIYLRAFLGFVISFCIVLFAGRPFIKYLKIKKFGEEIRDDGPSSHFSKKGTPTMGGVLIIAAVLLTSIFINDLTNSLILLVLLSTIMFAAIGFIDDYRKFTVSKKGLAGKKKLLFQGAIGLIIWAYIYFIGLTGRPMVDLSLINPISAYPYYIGAIGLFFLIQIVLMGTSNAVNITDGLDGLAIMPMIICSTILGVIAYFTGHTELSSHLHLFYTVGSGELSVFLSAVTGAGLGFLWYNCYPAQIFMGDTGSLTLGGILGVIAIILKQELMLPIMGFIFVLEALSVILQVGSFKLRGKRIFKMAPIHHHFELMGIPESKVTMRFWIGTLIFGIIALGAIKMRGIL
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Q8RDQ0
Q8GEH7
METN_ERWPE
Methionine import ATP-binding protein MetN
Erwinia
MVFYTIGPQTPQIDKGQIYGIIGYSGAGKSTLIRLLNGLEKPGSGSVTIAGQDIAQASVEALRQARLKISMVFQHFNLLWSRTVSENIAFSLQISGTSKSVIQDRVQELIALVGLVGKEQAYPSQLSGGQKQRVGIARALANNPNVLLCDEATSALDPQTTDAILELLLDINRKLWLTIVLITHEMHVVRKICHRVAVMEEGRIVEEGEVLSLFTHPQQPITRQFVKQTSGYISANVPFNPQLVNIDNGKVLKLTFVGQSTQQPVIGELTLKYGLAFNMLHGIMTQTTNGTFGEIWLQVPASQSQLPRILADLHAYEISTEVVTNV
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q8GEH7
P52736
ZN133_HUMAN
Zinc finger protein 150
Homo
MAFRDVAVDFTQDEWRLLSPAQRTLYREVMLENYSNLVSLGISFSKPELITQLEQGKETWREEKKCSPATCPADPEPELYLDPFCPPGFSSQKFPMQHVLCNHPPWIFTCLCAEGNIQPGDPGPGDQEKQQQASEGRPWSDQAEGPEGEGAMPLFGRTKKRTLGAFSRPPQRQPVSSRNGLRGVELEASPAQSGNPEETDKLLKRIEVLGFGTVNCGECGLSFSKMTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHERTHSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRTHLEEKTIVCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKEKPYVCGVCGHSFSQNSTLISHRRTHTGEKPYVCGVCGRGFSLKSHLNRHQNIHSGEKPIVCKDCGRGFSQQSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKRKHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLHQMTHTGEKPYVCKTCGRGFSLKSHLSRHRKTTSVHHRLPVQPDPEPCAGQPSDSLYSL
May be involved in transcriptional regulation as a repressor.
P52736
B9M174
MURB_GEODF
UDP-N-acetylmuramate dehydrogenase
Geotalea
MTVDTLARLCTAVRGKVLVNEPLAGHTSLKVGGPADYFAIPADLADLEELIKVVRSLSLPYFIIGGGFNVLVGDGGFRGVAISLKELNGMESPSRGRIRAEAGATNQQLVNYATGKELTGLEFLSCIPGTIGGALSVNAGAHGQSTMEQVETLITMRDGRIFENEGRKRNFGYRYLELEPGEIVVAAVFSLSEGKAEAIGEKLESYRRHRLESQKIGYPNAGSFFKNPEGQQAWRLIDEAGFRGFQVGGAQVSEIHTNFLVNRGGASAADFITLAGMIKQKVLERSGILLQEEVRILDEYEQK
Cell wall formation.
B9M174
Q8CCS2
NALF1_MOUSE
Transmembrane protein FAM155A
Mus
MTRGAWMCRQYDDGLKIWLAAPRENEKPFIDSERAQKWRLSLASLLFFTVLLSDHLWFCAEAKLTRTRDKEHHQQQQQQQQQQQQQQQQQQQQQQRQQQRQRQQQRQRQQEPSWPALLASMGESSPAAQAHRLLSASSSPTLPPSPGGGGGSKGNRGKNNRSRALFLGNSAKPVWRLETCYPQGASSGQCFTVESADAVCARNWSRGAAAGEEQSSRGSRPTPLWNLSDFYLSFCNSYTLWELFSGLSSPSTLNCSLDVVLTEGGEMTTCRQCIEAYQDYDHHAQEKYEEFESVLHKYLQSDEYSVKSCPEDCKIVYKAWLCSQYFEVTQFNCRKTIPCKQYCLEVQTRCPFILPDNDEVIYGGLSSFICTGLYETFLTNDEPECCDIRSEEQTAPRPKGTVDRRDSCPRTSLTVSSATRLCPGRLKLCVLVLILLHTVLTASAAQNSTGLGLGGLPTLEDNSTRED
Auxillary component of the NALCN sodium channel complex, a channel that regulates the resting membrane potential and controls neuronal excitability.
Q8CCS2
Q9F466
HYDRA_PAEAU
Hydantoin racemase
Paenarthrobacter
MRILVINPNSSSALTESVADAAQQVVATGTIISAINPSRGPAVIEGSFDEALATFHLIEEVERAERENPPDAYVIACFGDPGLDAVKELTDRPVVGVAEAAIHMSSFVAATFSIVSILPRVRKHLHELVRQAGATNRLASIKLPNLGVMAFHEDEHAALETLKQAAKEAVQEDGAESIVLGCAGMVGFARQLSDELGVPVIDPVEAACRVAESLVALGYQTSKANSYQKPTEKQYL
Involved in the asymmetric conversion of racemic 5-substituted hydantoins to the corresponding L-amino acids. Catalyzes the racemization via enolization of D- and L-5-monosubstituted hydantoins. It shows preference for hydantoins with arylalkyl side chains such as 5-benzyl-hydantoin (BH) and 5-(3-indolymethylene)-hydantoin (IMH).
Q9F466
B8HPZ1
PRMA_CYAP4
Ribosomal protein L11 methyltransferase
unclassified Cyanothece
MVSSWWEIQVVGDAALEEGISWRLQSFGCQGTASQKQNHDCHMTGYLPQKQVNHLDLAALSLWLAQDAIALGFLPPTTRWKLINEEDWATSWQQYWHPQEVGDRLLIYPAWLDLPEHCERLLLRLDPGVAFGTGTHPTTQLCLEALEMHLDQTFGPVEQVTVADIGCGTGILSIAALRLGAKQAFAVDLDPLAVESADRSRDLNEIPPEQMIVQQGSVEQVPHPVQGIVCNILAETIIDLIPTLATISQPHTWAAFSGILVTQAKSVVDALEQQGWQVGSLWQRQDWCCINAHRL
Methylates ribosomal protein L11.
B8HPZ1
P0AG78
SUBI_ECOLI
Sulfate starvation-induced protein 2
Escherichia
MNKWGVGLTFLLAATSVMAKDIQLLNVSYDPTRELYEQYNKAFSAHWKQQTGDNVVIRQSHGGSGKQATSVINGIEADVVTLALAYDVDAIAERGRIDKEWIKRLPDNSAPYTSTIVFLVRKGNPKQIHDWNDLIKPGVSVITPNPKSSGGARWNYLAAWGYALHHNNNDQAKAQDFVRALYKNVEVLDSGARGSTNTFVERGIGDVLIAWENEALLAANELGKDKFEIVTPSESILAEPTVSVVDKVVEKKGTKEVAEAYLKYLYSPEGQEIAAKNYYRPRDAEVAKKYENAFPKLKLFTIDEEFGGWTKAQKEHFANGGTFDQISKR
This protein specifically binds sulfate and is involved in its transmembrane transport.
P0AG78
Q9P3U4
HEL1_SCHPO
RING-type E3 ubiquitin transferase dbl4
Schizosaccharomyces
MSDLLDDEFYEEEFENDLLDASEFEDEFDEDAEIDDDGFTVERKRRRAHSVSYRVVSVRDLRASLNEKINQLTSIIDLTREQVLGLYRYFKWNRERLLERYIDAPEESLQKAGVGLSGSKQREVVHHEGTCEICYDEGCLPFFSAECDHEFCLACYRQYLDSRISEGESVIQCPEESCTQIVSIQSITKVLDEKSLDRYHRLLDRSFVDDNDHLRWCPAPDCEFAIECHVTQASLSSVVPTVTCNCGKQFCFGCGHDNHQPTICPLVKIWLQKCQDDSETANWIHANTKECPKCSTTIEKNGGCNHMTCKKCKYEFCWVCLGPWTEHGNNWYTCNRYEEKSSTSARDSQSKSRASLERYLHYYNRFANHEQSAKLDHELYEHTHKRMTQMQVDSNLSWVEVQFLKNAVDILFQCRQTLKWTYAFAYYLARNNQTEIFEDNQRDLELAVENLSELCERPCQDCSLSVFKQRVLDKTVYVRSRRDVLLDDTARGLAEGRWEYVVDV
Probable ubiquitin-protein ligase involved in the degradation-related ubiquitination of histones. Contributes to the post-translational regulation of histone protein levels by polyubiquitination of excess histones for subsequent degradation.
Q9P3U4
Q03637
COLQ_TORMA
AChE Q subunit
Torpedo
MLGILLQKATATLASGLNSSRAGMFPIALGLLLQLFFDHALAESTFLDKAFSLQAALLPMEHKKRSVNKCCLLTPPPPPMFPPPFFTETNILQEVDLNNLPLEIKPTEPSCKITCIIGPPGPSGPQGPQGIQGIMGPKGEIGEIGRPGRKGRPGVRGPRGMPGSPCSPGPIGPRGEKGDIGLTGLPGARGPMGPKGLTGQKGEKGIIGEKGQQGIKGEMGVMGLPGMLGQKGEMGPKGVSGAPGHRGPVGRPGKRGKTGLKGDIGPPGIMGPSGPPGPSGLPVMSGSGHLMVGPKGERGLPGPVGRCDCNLPQTVVNPSYNKFPTLINPPQVPAIFVVDSEDELEKLNTENALAFRKDQKSLYYRDTVGWLPIQIAPIQQMRQNPTGFCGDEIVQVENGEECDDGNRIVTDSCINCKQAYCGDGYLQSGLEECDGKDFGYHTCKSYLPGSYGELKCTSYCYIDSTGCRYFT
Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.
Q03637
A9MSA2
RLMM_SALAR
23S rRNA 2'-O-ribose methyltransferase RlmM
Salmonella
MNKVVLLCRPGFEKECAAEITDKAGKRELFGFARVKENTGYVIYECYQPEDGEKLISELPFSSLIFARQWFVVGELLQHLPPEDRITPIVGMLQGVVEKGGELRVEVADTNESKELMKFCRKFTVPLRAALRDAGVLTHYETPKRPVVHVFFIAPGCCYTGYSLAHNHSPFYMGIPRLKFPSDAPSRSTLKLEEALHVFIPEDEWDERLANGMYAVDLGACPGGWTYQLVKRNMWVYSVDNGPMAQSLMDTGQVTWLREDGFRYRPNRNNISWMVCDMVEKPAKVTALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYLQAQLDEHGVNAQIQARQLYHDREEVTVHVRRLWAAVGGRRDER
Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
A9MSA2
Q4FP17
LEU3_PELUB
Beta-IPM dehydrogenase
Candidatus Pelagibacter
MIKIKKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDEDLAGGCSYDKHGTPITDEVFYKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLRKELKLFANLRPAICFEQLVDASTLKPEIVSGLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFDLARKRSNRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQFDVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEIANPIASILSFAMALRYSLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTSAMGDAIISKLQ
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
Q4FP17
Q3SGF7
RSMA_THIDA
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Thiobacillus
MHTPRKRFGQNFLIDDGIVHAIVNAIHPQAGETVVEIGPGLGALTRPLLERLPHLHAVELDRDIIARLRRAWPPERLTLHAGDALKFDFGSLGDDLRIVGNLPYNISTPLLFHLLEFAPRIRDMHFMLQKEVVERMVASPATADYGRLSIMLQRRFHMEWLLDVPPTAFDPPPKVESAVVRLIPKSTAEVPSVDEALFARVVAAAFAQRRKTLRNTLSALMRPEDFVALGIDPGLRAEALHVADYEAITAYLATR
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q3SGF7
P0DPT2
CA1B_CONCT
C1.2
Pionoconus
SDGRNEAANDEASDVIELALKGCCSNPVCHLEHPNACGRRR
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks rat neuronal nAChR alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=128.9 nM) and alpha-7/CHRNA7 (IC(50)=1511 nM) . In vivo, intramuscular injection into zebrafish does not produce any effect on the locomotion of zebrafish .
P0DPT2
Q7NTU0
LOLD_CHRVO
Lipoprotein-releasing system ATP-binding protein LolD
Chromobacterium
MNKVLSCRSLGKRYQEGKLALDVLSGVDLEVGKGEHLAIVGASGSGKSTLLHLLGGLDTPTAGTVEVLGRDLSKLSETERGKLRNESMGFVYQFHHLLPEFTALENVMMPLLIRRMDKGEAARRAAEMLERVGLGKRLEHKPGELSGGERQRAAIARALVTQPACLLADEPTGNLDAHTASQVFELMLELNRTLGTSLIIVTHDLELAGRTQRVLRLNEGRLAVSDTVSA
Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
Q7NTU0
Q00016
IFR_CICAR
NADPH:isoflavone oxidoreductase
Cicer
MASQNRILVLGPTGAIGRHVVWASIKAGNPTYALIRKTPGDINKPSLVAAANPESKEELLQSFKAAGVILLEGDMNDHEALVKAIKQVDTVICTFGRLLILDQVKIIKAIKEAGNVKRFFPSEFGLDVDRHDAVDPVRPVFDEKASIRRVVEAEGVPYTYLCCHAFTGYFLRNLAQFDATEPPRDKVIILGDGNVKGAYVTEADVGTYTIRAANDPRTLNKAVHIRLPHNYLTSNEVVSLWEKKIGKTLEKSYISEEKVLKDINVSTFPHNYLLALYHSQQIKGDAVYEIDPAKDAEAYDLYPDVKYTTADEYLDQFV
Reduces achiral isoflavones to chiral isoflavanones during the biosynthesis of chiral pterocarpan phytoalexins.
Q00016
Q8R7Y5
ECFA2_CALS4
Energy-coupling factor transporter ATP-binding protein EcfA2
Caldanaerobacter
MPIKVENVSFIYNEGTPYATVALKDINFSIDDEEFVGIIGHTGSGKSTLIQQLNGLLKPSKGKIYINGIDITDKKVSLKDIRKQVGLVFQYPEYQLFEETVFKDIAFGPSNLGLSEEEVKERVYEAMEIVGISKELADKSPFELSGGQKRRVAIAGILAMRPKILILDEPTAGLDPKGKQEILNKIKEIHDKYKMITILVSHNMEDIARIADKIIVMNRGKIELIGTPREVFREAERLEKIGLSVPQITSLARELRKRGVPIPPDVLTIEEAKEHILRYLRGTKNV
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Q8R7Y5
Q32K50
KEFF_SHIDS
Quinone oxidoreductase KefF
Shigella
MILIIYAHPYPHHSHANKRMLEQARTLDGVEIRSLYQLYPDFNIDIAAEQEALSRADLIVWQHPMQWYSIPPLLKLWIDKVLSHGWAYGHGGTAPRGKHLLWAVTTGGGESHFEIGAHPGFDVLSQPLQATAIYCGLNWLPPFAMHCTFICDDETLEGQARHYKQRLLEWQEAHHG
Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC.
Q32K50
Q5U2U6
CDIP1_RAT
LITAF-like protein
Rattus
MSNEPPPPYPGGPTAPLLEEKSGAPHTPGRTSPAVMQPPPGMPLPSADIAPPPYEPPGHPVPQPGFVPPHMNADGTYMPAGFYPPPGPHPPMGYYPPGPYPPGSYPGPGGHTATVLVPSGAATTVTVLQGEIFEGAPVQTVCPHCQQAITTKISYEIGLMNFVLGFFCCFMGCDLGCCLIPCLINDFKDVTHTCPSCKAYICTYKRLC
Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
Q5U2U6
Q6K508
GLUD1_ORYSJ
Glutelin type-D 1 basic chain
Oryza sativa
MATTTSLLSSCLCALLLAPLFSQGVDAWESRQGASRQCRFDRLQAFEPLRKVRSEAGDTEYFDERNEQFRCAGVFVIRRVIEPQGLVVPRYSNTPALAYIIQGKGYVGLTFPGCPATHQQQFQLFEQRQSDQAHKFRDEHQKIHEFRQGDVVALPASVAHWFYNGGDTPAVVVYVYDIKSFANQLEPRQKEFLLAGNNQRGQQIFEHSIFQHSGQNIFSGFNTEVLSEALGINTEASKRLQSQNDQRGDIIRVKHGLQLLKPTLTQRQEEHRQYQQVQYREGQYNGLDENFCTIKARVNIENPSRADYYNPRAGRITLLNNQKFPILNLIGMGAARVNLYQNALLSPFWNINAHSVVYIIQGSVRVQVANNQGRSVFNGVLHQGQLLIIPQNHAVIKKAEHNGCQYVAIKTISDPTVSWVAGKNSILRALPVDVIANAYRISRDEARRLKNNRADEIGPFTPRFPQKSQRGYQFLTEGLSLIGM
Seed storage protein.
Q6K508
Q5F3W2
INSI2_CHICK
Insulin-induced gene 2 protein
Gallus
MAENDAKPTLPKKSGPYISSVTSHGMNLVIRGIVLFFIGVFLALVLNLLQIQRNVTLFPPDVITSIFSSAWWVPPCCGTASAVIGLLYPCMDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFANNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATLVSQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHED
Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs). Binds oxysterol, including 22-hydroxycholesterol, 24-hydroxycholesterol, 25-hydroxycholesterol and 27-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBPs to the Golgi. Sterol deprivation reduces oxysterol-binding, disrupting the interaction between INSIG2 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBPs. Also regulates cholesterol synthesis by regulating degradation of HMGCR.
Q5F3W2
Q3IMX0
RL19E_NATPD
50S ribosomal protein L19e
Natronomonas
MTDLKAQKRLAADILDVGENRVRFDPDAQAEIADAITREDIRELIEDGTIEAKTAKGNSRGRARKRQQKRAYGHKKGHGSRKGRSGGRQNEKEDWQSRIRAQRRELRELRDAGDISREQYRELYDMASGGEFDSVADLNRYIDDKHGEQ
Binds to the 23S rRNA.
Q3IMX0
Q48RI5
PEPX_STRPM
X-prolyl-dipeptidyl aminopeptidase
Streptococcus
MRYNQFSYIPTSLERAAEELKELGFDLDLQKTAKANLESFLRKIFFHYPDSDYPLSHLIAKNDMDALSFFQSEQELSKEVFDLLALQVLGFIPGVDFTEADAFLDKLAFPIHFDETEIIKHIHHLLATRCKSGMTLIDDLVSQGMLTMDNDYHFFNGKSLATFDTSQLIREVVYVEAPLDTDQDGQFDLIKVNIIRPQSQKPLPTLMTPSPYHQGINEVANDKKLYRMEKELVVKKRRQITVEDRDFIPLETQPCKLPIGQNLESFSYINSYSLNDYFLARGFANIYVSGVGTAGSTGFMTSGDYAQIESFKAVIDWLNGRATAYTSHSKTHQVRADWANGLVCTTGKSYLGTMSTGLATTGVDGLAMIIAESAISSWYNYYRENGLVCSPGGYPGEDLDVLTELTYSRNLLAGDYLRHNDHYQELLNQQSQALDRQSGDYNQFWHDRNYLKNAHQIKCDVVYSHGLQDWNVKPRQVYEIFNALPSTINKHLFLHQGEHVYMHNWQSIDFRESMNALLCQKLLGLANDFSLPEMIWQDNTCPQNWQERKVFGTSTIKELDLGQELLLIDNHYGEDEFKAYGKDFRASKAALFKGKANQALIDILLEEDLPINGEIVLQLKVKSSENKGLLSAQILDYGKKKRLGDLPIALTQSSIDNGQNFSREPLKELPFREDSYRVISKGFMNLQNRNNLSSIETIPNNKWMTVRLPLQPTIYHLEKGDTLRVILYTTDFEHTVRDNSNYALTIDLSQSQLIVPIASN
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Q48RI5
Q9FNF8
P4KG3_ARATH
Phosphatidylinositol 4-kinase gamma 3
Arabidopsis
MSVASVALSPALEELVNFPGIIGRFGFNLDDPILVFLTIAGSVIPKRVMESDSIASVKLRIQSIKGFFVKKQKLLYDGREVSRNDSQIRDYGLADGKLLHLVIRLSDLQAISVRTVDGKEFELVVERSRNVGYVKQQIASKEKELGIPRDHELTLDGEELDDQRLITDLCQNGDNVIHLLISKSAKVRAKPVGKDFEVFIEDVNHKHNVDGRRGKNISSEAKPKEFFVEPFIVNPEIKLPILLKELISSTLEGLEKGNGPIRSSDGSGGAYFMQDPSGHKYVSVFKPIDEEPMAVNNPHGQPVSVDGEGLKKGTQVGEGAIREVAAYILDYPMTGPRTFPHDQTGFAGVPPTTMVKCLHKDFNHPNGYSFSPENTKIGSLQMFVSNVGSCEDMGYRVFPVDQVHKISVLDIRLANADRHAGNILVSRDGKDGQMVLTPIDHGYCFPNKFEDCTFEWLYWPQAKEPYSSETLEYIKSLDPEKDIELLRFHGWEIPPSCTRVLRISTMLLKKGSAKGLTPFTIGSIMCRETLKEESVIEQIIHDAEAIVPTETTEDEFISTVSAIMDNRLDQYAWN
The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).
Q9FNF8
P04570
SCP2_BRALA
Sarcoplasmic calcium-binding proteins II, V, VI, and VII
Branchiostoma
GLNDFQKQKIKFTFDFFLDMNHDGSIQDNDFEDMMTRYKEVNKGSLSDADYKSMQASLEDEWRDLKGRADINKDDVVSWEEYLAMWEKTIATCKSVADLPAWCQNRIPFLFKGMDVSGDGIVDLEEFQNYCKNFQLQCADVPAVYNVITDGGKVTFDLNRYKELYYRLLTSPAADAGNTLMGQKP
Like parvalbumins, SCPs seem to be more abundant in fast contracting muscles, but no functional relationship can be established from this distribution.
P04570
Q317B9
PURA_OLEA2
IMP--aspartate ligase
Oleidesulfovibrio
MSNVVIMGAQWGDEGKGKIVDLLSREIDVIVRFQGGNNAGHTVIVGDKSYILHLIPSGILHEGKTCLIGNGVVLDPVVFWKEVEALAERGIDVGPQRLMISRKAHVIMPYHKALDVAREDFKNKESRIGTTGRGIGPCYEDKMSRIGVRAGDLADPALLRSKIEAALVEKNALFTALYGREAMSVDAVFDEVMAVGGRLVPYLTDVSSVIEDAWANDSGVMFEGAQGTHLDIDHGTYPFVTSSNTVAGNAAAGSGIPASRLDRVVAIVKAYTTRVGAGPFPTELDDEAGNHMQSVGHEFGATTGRKRRCGWLDCALLRESVRLNGPTDIALTKLDVMSGLKELKICVAYEYNGQRLQHPPQEQNGLAHVTPVYETMPGWDDDITAAKTWEDLPEAARNYICRIEELLGVPVSMISVGPERDQTLNRK
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q317B9
Q21360
MAK1_CAEEL
MAP kinase-activated protein kinase mak-1
Caenorhabditis
MMFEYEEDEDPMEQQKHEEFKHHSTDHSGSPQENPFRFSYDTGKRAASMFVTPSSEDLIAYGTKHLLDSPTAVQRSLVLNATTSLNIDCDLSSDDDLSPTTQRKICFCASQNPAETQEQGLRPAKSTLAISFPCHQHQITEDYTISAEIIGIGESGKVMACYQKVTGEKFALKVLRDSQKARREVELHWLTNAHENVVSILDIYENTFDNVKCLLMVVEFLEGGDLLSQFESQGSIPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENILCSGTGDNCVYKLGDYGFAKRPERNVLMESPCCTPFYAPPEVLGRERYDKSCDMWSLGVAMYILLCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPSDRLTIHELMATPLVTGEPIVPGKHITTAIAIPGADESECGGGVFDDGFIVEEEETPDTVAEILPVPKSVRFLRDGVKAPRLHSIQEEVGRAMEIMRMGTDQVYIKNPTASCNNLFERRRAVHLSIPRVYC
Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin.
Q21360
Q74ZL5
H2B1_ASHGO
Histone H2B.1
Eremothecium
MSSKASKAPASKAPAEKKPAAKKTSSSVDASKKRTKTRKETYSSYIYKVLKQTHPDTGISQKSMSILNSFVNDIFERIASEASKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSSTQA
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q74ZL5
Q9P0K7
RAI14_HUMAN
Retinoic acid-induced protein 14
Homo
MKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAFHLAAAKGHVECLRVMITHGVDVTAQDTTGHSALHLAAKNSHHECIRKLLQSKCPAESVDSSGKTALHYAAAQGCLQAVQILCEHKSPINLKDLDGNIPLLLAVQNGHSEICHFLLDHGADVNSRNKSGRTALMLACEIGSSNAVEALIKKGADLNLVDSLGYNALHYSKLSENAGIQSLLLSKISQDADLKTPTKPKQHDQVSKISSERSGTPKKRKAPPPPISPTQLSDVSSPRSITSTPLSGKESVFFAEPPFKAEISSIRENKDRLSDSTTGADSLLDISSEADQQDLLSLLQAKVASLTLHNKELQDKLQAKSPKEAEADLSFDSYHSTQTDLGPSLGKPGETSPPDSKSSPSVLIHSLGKSTTDNDVRIQQLQEILQDLQKRLESSEAERKQLQVELQSRRAELVCLNNTEISENSSDLSQKLKETQSKYEEAMKEVLSVQKQMKLGLVSPESMDNYSHFHELRVTEEEINVLKQDLQNALEESERNKEKVRELEEKLVEREKGTVIKPPVEEYEEMKSSYCSVIENMNKEKAFLFEKYQEAQEEIMKLKDTLKSQMTQEASDEAEDMKEAMNRMIDELNKQVSELSQLYKEAQAELEDYRKRKSLEDVTAEYIHKAEHEKLMQLTNVSRAKAEDALSEMKSQYSKVLNELTQLKQLVDAQKENSVSITEHLQVITTLRTAAKEMEEKISNLKEHLASKEVEVAKLEKQLLEEKAAMTDAMVPRSSYEKLQSSLESEVSVLASKLKESVKEKEKVHSEVVQIRSEVSQVKREKENIQTLLKSKEQEVNELLQKFQQAQEELAEMKRYAESSSKLEEDKDKKINEMSKEVTKLKEALNSLSQLSYSTSSSKRQSQQLEALQQQVKQLQNQLAECKKQHQEVISVYRMHLLYAVQGQMDEDVQKVLKQILTMCKNQSQKK
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
Q9P0K7
Q817W6
TGT_BACCR
tRNA-guanine transglycosylase
Bacillus cereus group
MTAIRYEFIKTCKQTGARLGRVHTPHGSFDTPTFMPVGTLATVKTMSPEELKAMDSGIILSNTYHLWLRPGHEIIREAGGLHKFMNWDRAILTDSGGFQVFSLSDFRRIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPFPATFEYMKKSVERTSRWAERCLKAHERPQDQGLFGIVQGGEYEELRRQSAKDLVSMDFPGYAVGGLSVGEPKDIMNRVLEFTTPLLPDNKPRYLMGVGSPDSLIDGAIRGIDMFDCVLPTRIARNGTCMTSEGRLVVKNAKFARDFGPLDPNCDCYTCKNYSRAYIRHLMKCDETFGIRLTSYHNLHFLLNLMEQVRQAIREDRLGDFREEFFEQYGFNKPNAKNF
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Q817W6
B2JG21
RL9_PARP8
50S ribosomal protein L9
Paraburkholderia
MQIILLEKVLNVGNLGDIVKVKDGYARNFLIPNKKARRATKEAIAEFEVRRAELEKVAAEKLSAAQAQGEKLSGMTVQIAQKAGVDGRLFGSVTNADIAAALGKQGFEVEKAQVRLPEGPLKMVGDHPVHVSLHTDVTVDVTVSVLGEHV
Binds to the 23S rRNA.
B2JG21
P35362
OPSD_SPHSP
Rhodopsin
unclassified Sphodromantis
MSLINEPSYSAYSWGGQGGYGNQTVVDKVLPEMLHLIDPHWYQFPPMNPLWHGLLGFVIGCLGFVSVVGNGMVIYIFSTTKGLRTPSNLLVVNLAFSDFLMMLSMSPPMVINCYYETWVLGPFMCELYALLGSLFGCGSIWTMVMIALDRYNVIVKGLAAKPMTNKTAMLRILGIWAMSIAWTVFPLFGWNRYVPEGNMTACGTDYLNKEWVSRSYILVYSVFVYFLPLATIIYSYWFIVQAVSAHEKQMREQAKKMNVASLRSAENANTSAECKLAKVALMTISLWFFAWTPYLVTDFSGIFEWGKISPLATIWCSLFAKANAVYNPIVYGISHPKYRAALNKKFPSLACASEPDDTASQASGATTVSDEKSASA
Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.
P35362
A4FYN1
FLPA_METM5
Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase
Methanococcus
MEKIKVKEIFNNVYSVDFGDGLKRIATKSLIPGKRVYGEKLVYSDNIEYRVWNPNKSKLGAAIINGLKKMPIKKGTKVLYLGASAGTTPSHVADIAENSLVYALEFAPRIMREFIDSCNERKNLIPVLGDANRPQDYSNIVEKVDVIFEDVAQPNQAEILVKNAKWFLKENGYAMISIKARSVDVTKNPREIFAEQKKILIEGGFEIVDEVNIEPFEKDHMMMVGIWKGN
Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
A4FYN1
P01523
CM3A_CONGE
Myotoxin I
Gastridium
MMSKLGVLLTICLLLFPLTALPMDGDEPANRPVERMQDNISSEQYPLFEKRRDCCTPPKKCKDRQCKPQRCCAGR
Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks rat Nav1.4/SCN4A (IC(50)= 19-110 nM) . It also moderately blocks rNav1.1/SCN1A (Kd=260 nM), rNav1.2/SCN2A (IC(50)=2.7-17.8 uM), and mNav1.6/SCN8A (IC(50)=680 nM) . The inhibition is reversible. In vivo, induces paralysis to an isolated skeletal muscle preparation from frog (cutaneous pectoralis) within a few minutes .
P01523
Q65HX2
SCPB_BACLD
Segregation and condensation protein B
Bacillus
MTLDIVNWKAIVEALLYAAGDEGLTKKQLLSVLEVDEAELLDIMLDVKETYEKEDRGIELVEYADTYMLSTKKEFAVYLKKLIEAPSKGLSQAALEVLAIVSYKQPITRAEVEEIRGVKSERILQSLVAKALLCEVGRADGPGRAILYGTTETFLEQFGLKTLEELPPLPENVEEDGVQEEADLFFENFNQTFEDLK
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.
Q65HX2
Q8ZPZ1
RLUE_SALTY
rRNA-uridine isomerase E
Salmonella
MRQLISSENTMQKTSFRNHYVKRFSSRQASKSRKENQPKRVVLFNKPYDVLPQFTDEAGRRTLKDFIPVQGVYAAGRLDRDSEGLLVLTNDGALQARLTQPGKRTGKIYYVQVEGIPDNAALQALRTGVTLNDGPTLPAGIEIVAEPDWLWPRTPPIRERKNIPTSWLKVTLYEGRNRQVRRMTAHVGHPTLRLIRYSMGDYTLNGLDNGQWREIAQEKDR
Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA.
Q8ZPZ1
B3EGT4
MIAB_CHLL2
tRNA-i(6)A37 methylthiotransferase
Chlorobium
MPRDRRKFYIHTFGCQMNQADSGIIAALLEQDGYQQASSEEEAGIIMLNTCAVRENAVERIAHYLQHVKGFKRKCPELLVGLTGCIPQYRREELFTVFPVIDFLAGPDTYRVLPVLIAEAGKGRAARLDFNPFETYDGVTQARTQSLTAFVPIMRGCNNMCAFCVVPFTRGRERSHPFGSVLDEVRALAESGCREITLLGQNVNSYHDSQSGADFSRLLDAVSREAPETRIRFTTSHPKDMSHSLVETMASRPNICNHLHLPVQSGSTRMLARMNRGHDIEDYRNKIELLRERIPGISLSTDLIAGFCGESDADHCQTLELMREVRFDSAFMFYYSVRPGTLAARTMPDDVPEEVKKQRLQEIIDLQNGISAELLRLAIGSVVEVLVESESRRSSDQLMGRTGGNRVVVFDRGIHQPGDMVRVMITGSTSATLIGRAAENQH
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
B3EGT4
D4CZZ6
NSCR_TRIVH
Neosartiricin B biosynthesis protein R
Trichophyton
MEKRGPKRRQEAAHLSCELCRERKVKCDKLDPCTNCSSAGVICVPVRRPRLPRGAHAQRLRRISPEDPEAPIQIDIASPADAGTIADDDLKERIRRLEALVDSMRSSNHVSKQLIKNFQTNKDQEAQDTIESTLNRIDEDSLLIKGPRVHPSDGGLRILGLSGSSSPETGWASIIEDREVSMQLCQVYLLNVDPVIKILHRPSLEKWMLEGQRYLGLPEGHAAVESLGAAICYVAATSLTETQSWARFHTTKSSIVARARRACETTLEKSSPLLSPDVTTLQAFVLYLVARRSEDPSRAVWTLMAFAVRIAKALDLPRGIDDNFFGQQMRKRLWLAICLLDFQTSLSQPSEPLITVAEATSLFSPPRHINDSDFDPTTSHDIPDREGLTDTTFSLVSHHVQAAGRLLNFEPSVKDDGSRQQHVQNFEQRTLRLLLYCDPESTPYAWFTWHRIQCFVSGARLSAIRPLIHQHGGHPIPILDANEGTSILSLALNILEKVQLVHTDPRGEGFRWFVTVPWQPLAIAISECYICQDRSLVQRAWPIVEAAFQQHEATVSGSSKAISITLERLMCRVRGKLLPSLELSRPGEDLALVTEAPISTSPQKVDPLVFSLDSPLLIAGQEQLLDADQSWAAWEEVIASLHYDETGRADMFLS
Transcription factor that specifically regulates the neosartoricin B biosynthesis gene cluster .
D4CZZ6
P0DUH8
SCX6_CENTE
Beta-toxin Ct6
Centruroides
MKTFVLALCLVLIGMVYAKDGYLVSKHTGCKLGCSPKIGDRYCHIECTSMNHKGDEGYCYWLACYCKGMPENAEVYPLPNKSCGK
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing.
P0DUH8
Q8W8V0
RR7_PSINU
30S ribosomal protein S7, chloroplastic
Psilotum
MSRQSETKKRTAKSDPIYRNRSVSMFINHILKDGEKSLAHKILYRAMKQIKRKTKKNPLSVLRQAVYRVTPNVAVKSRRVGGSNYQVPVEVKPARGKALAIRWIVGASRNRSGRSMASKSSYELIDAARNTGSAIRKKEETHKMAEANKAFAHLR
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit.
Q8W8V0
P57867
DAPB_PASMU
4-hydroxy-tetrahydrodipicolinate reductase
Pasteurella
MTLRVAIVGAGGRMGRQLIQAVSETEGVVLGAAFERQGSSLLGADAGELANVGHLGVQITDDLASQQDQFDLLIDFTRPEGTLAHLAFCVAQHKNMVIGTTGFDDDGKAKIQQAADSIGIVFASNFSVGVNLVFKLLEKAAKVMGDYCDIEIIEAHHRHKVDAPSGTALSMGEHIAKTLGRDLKTHGVFTRDGITGERKRDEIGFATIRASDVVGEHSVWFADIGERVEIAHKATSRMTFAKGAVRAAKWLAQKEKGLFDMTDVLDLNQL
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
P57867
Q2GL53
RS3_ANAPZ
30S ribosomal protein S3
phagocytophilum group
MGQKSNPIGLRLKIVGTWDSLWYANRDYATKLHEDLLLRSFVKKTFHHAAVSKVVIARKVDAVIINIHSARPGVIIGKKGVDIDRIKQKIAKMVNHEVELHIVEVKKPDLKAVLIAENIAQQLEKRVSFRRAMKRGVQNCLKMGAKGVKVSCAGRLGGAEIARTEWYKEGSVPLHTFRANIDYSCVEAKTIYGIVGVKVWVYVGDSRAVVE
Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.
Q2GL53
A7FIG9
PTH_YERP3
Peptidyl-tRNA hydrolase
Yersinia
MSSIKLIVGLANPGAEYAQTRHNAGAWYVDLLAERHNQSLKEESKFFGYTARLNLAGQDIRLLVPATFMNLSGKAVAAMASFYRILPEEILVAHDELDILPGMAKLKLGGGNGGHNGLKDIQNKLGNNPNFYRLRIGIGHPGDKSKVTGFVLGKPPASEQTLIDNAIDESIRCTEVLLNEGMTKAMNRLHAFKASA
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
A7FIG9
O51551
CHED_BORBU
Probable chemoreceptor glutamine deamidase CheD
Borreliella
MLNHFNFKLKRDVTIIVPGEAFVSNKRVISTILGSCVAVVLCDESNNLIGMNHYVLVKSDLDISPDQRGRYGIYAIPMLINAMLENGASKSNLKAKLFGGTNFMAKGSVKVGLENSEFAVNTLNKYRIPILAKDFDQSKSRKIFAFPENFKVIVEYPDGTKVF
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
O51551
Q1BGJ2
RHAM_BURCA
Type-3 mutarotase
Burkholderia cepacia complex
METIAFRMHLHPGKRDEYRRRHDAIWPELADALRAAGISDYWIFLDDDTHHLFAVLKRPADHRIAQLAETDVMRRWWAYMADLMATGPDGRPVEKALEPMFHLE
Involved in the anomeric conversion of L-rhamnose.
Q1BGJ2
Q8PV99
ASPD_METMA
L-aspartate dehydrogenase
Methanosarcina
MLKIGIIGCGFIGGQICRAIDSGEIDAELYALCDSSESKAFGLAKSLNTCKPAYMKIEELISSVDLVVESASQNAVRFIVPQALKAGCSVMVLSVGALADKELRETLFGLAKKHNCKLYFPSGAVVGIDGINSAHAAGISSVTLTTRKPPSGLMGAPYVVEHGIELEKLEKETILFEGTASEAVKAFPANVNVAATISLAGIGFERTMVRVIADPSLSRNIHEINVEGEFGKFCTKVENLPSPENPKTSYLAALSAISTLKKILNPVQIGT
Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.
Q8PV99
B6ES34
GCSH_ALISL
Glycine cleavage system H protein
Aliivibrio
MEKDLKFTASHEWVRENGDGTVTVGISNHAQGLLGDVVFVDLPDVDDEVTAGENFSLVESVKAASDIYAPISGVIVEINEELEDSPELVNEEPYEGGWIARIKLSDDGDLENLIPGDQYLESIEEE
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
B6ES34
Q74LQ3
PHNC_LACJO
Phosphonates import ATP-binding protein PhnC
Lactobacillus
MIQLKNVSKIYDNGTVGLKDINLNIDKGEFIVVVGLSGAGKSTLLRSINRLQDVSEGDIIIDGKSITSAKGKDLREIRRDIGMIFQSFNLVKRSSVLRNVLTGRVGYYPTWKTTFNLFTKEDKQKAYEALQRVDLADKVYTRADQLSGGQQQRVAIARVLTQNPKIILADEPTASLDPQTSRRVMHDLKMLNEEYGMTVVANLHSVELAKEFGDRVIGVRAGQIVYDGKMSETSQAVFDDIYNGGNGKKGEEDA
Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system.
Q74LQ3
Q01718
ACTHR_HUMAN
Melanocortin receptor 2
Homo
MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSRYW
Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).
Q01718
Q8NGG4
OR8H1_HUMAN
Olfactory receptor OR11-180
Homo
MGRRNNTNVPDFILTGLSDSEEVQMALFILFLLIYLITMLGNVGMILIIRLDLQLHTPMYFFLTHLSFIDLSYSTVITPKTLANLLTSNYISFMGCFAQMFFFVFLGAAECFLLSSMAYDRYVAICSPLRYPVIMSKRLCCALVTGPYVISFINSFVNVVWMSRLHFCDSNVVRHFFCDTSPILALSCMDTYDIEIMIHILAGSTLMVSLITISASYVSILSTILKINSTSGKQKALSTCASHLLGVTIFYGTMIFTYLKPRKSYSLGRDQVASVFYTIVIPMLNPLIYSLRNKEVKNALIRVMQRRQDSR
Odorant receptor.
Q8NGG4
Q4QMD8
MLTC_HAEI8
Murein lyase C
Haemophilus
MKKYLLLALLPFLYACSNSSNQGINYDEAFAKDTQGLDILTGQFSHNIDRIWGVNELLVASRKDYVKYTDSFYTRSHVSFDEGNIVIETQQDLNRLHNAIVHTLLMGADAKGIDLFTSGDVPISSRPFLLGQVVDHQGQQIANQVIASNFATYLIQNKLQTRRLQNGHTVQFVSVPMIANHVEVRARKYLPLIRKAAQRYGIDESLILGIMQTESSFNPYAISYANAIGLMQVVPHTAGRDVFAMKGKGGQPSTRYLYDPANNIDAGVSYLWILQNQYLDGITNPTSKRFAMISAYNSGAGAVLRVFDNDKDTAIYKINQMYPEQVYRILTTVHPSSQARNYLLKVDKAQKKFRVRR
Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.
Q4QMD8
Q1QUF2
RSMC_CHRSD
rRNA (guanine-N(2)-)-methyltransferase RsmC
Chromohalobacter
MSAETPPCQLLERQSEAYRDWLWVAPPHDAWLHTVGGSVWSADATICQAWRARGRPVHADLAPTLTAPVPGAVLFWPKTHALGEWWLLALCAALPEGTPLQVVGEHQGGVKRVLKSLAALGLGCRKVDSARRCTLYATRTARLALSPEAAWTRFEAAGLTLESHPGVFGHGKLDDGTRQLLEVLPTALGDPAGQRVLDVGCGDGILGAWLGVRGAQVAAVDLDAFAVAATRRTFQANGVAGEAWQSDVFGDVSGSYDAIVSNPPFHQQRAIDYGPAERLIREAPARLVPGGRLVLVANAFLPYPRWLEDAFGEFTVLADDRRFRVYQAVKTRR
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
Q1QUF2
Q6DH87
FUND1_DANRE
FUN14 domain-containing protein 1
Danio
MADRGEDAESEDELYEVVNITDYARRHQWWSRVFGNSTGPIAEKYSVASQIMMGGVSGWCAGYLFQRVGKLVATAVGGGFLLLQIANHSGYVQVDWRKVEKDVNKAKKHLKKNAKKAAPELNTFIEDSTEFVKRNIVISGGFVGGFLLGLAS
Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control.
Q6DH87
Q5HTK3
DNAJ_CAMJR
Chaperone protein DnaJ
Campylobacter
MEISYYEILEITQNADKETIKKAYRKMALKYHPDRNQGDKEAEDKFKLVNEAYEVLSNDEKRAIYDRYGKDALKGGGFGSSSSGFGGFEDLGDIFSSFFGEGFGSSRRRKSSNDEKIPSDFIVNLKLSFKEAVFGCKKNIDFTYKCSCKTCNGTGAKDGKLQTCPKCQGRGQVGVSQGFITFAQTCPDCQGIGEKASEKCSDCKGLGYNESKNSVELNIPEGVDTGMKLRVNAKGNILKNGTRGDMYVKIIAAEDDTFIRDDDDIYIEFPVFFTQAILGESIKVPTIRGEATLNLPKGAKDGQRFVLEKEGVKDVHSSRIGNQIVQISIKFPTSLNDEQKELLEKLSESFGIKDGMHQEQKGLFEKIANWFKS
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Q5HTK3
Q8XVV4
MNMA_RALSO
tRNA-specific 2-thiouridylase MnmA
Ralstonia
MSGKRVVVGMSGGVDSSVTAWLLKQQGYEVIGLFMKNWEDDDDSEYCSTRQDWIDVVSVADLIGVDVEAVNFAAEYKDRVFADFLREYSAGRTPNPDVLCNAEIKFKAFLDHAMALGADTIATGHYARVREAGGRFELLKAFDHTKDQSYFLHRLNQAQLSRTLFPLGEMPKTRVREIAAEIGLPNARKKDSTGICFIGERPFRDFLNRYLPTKPGPIRTPDGKTIGQHIGLAFYTLGQRKGIGIGGSRDGNGDAWYVARKDMAANTLYVAQGHDHPWLLAHTVHADDLSWVAGHPPAEGTQLAAKTRYRQADAPCAVTRATGDALTLTFQQAQWAVTPGQSAVLYDGDICLGGGIIASTEAASLEQAVA
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Q8XVV4
B2GBC9
UVRC_LIMF3
Excinuclease ABC subunit C
Limosilactobacillus
MASEYLEHKLALLPDQPGCYLMKNANAQIIYVGKAKNLKNRVRSYFKSSHTGKVAAMVEEVADFETIVTSSNKESFLLEITLIQKHQPYYNIKLKRGTGYPYIKITNERDPIIKITGQVKKDGAYYFGPYPNVYAAEETVHFIQKVFPLRRCHGYQGRPCLYYHLGQCLGCCFKEVPEEEYAVQTKRIKSFLNGNTAQVKKQLTARMERAAGQLEFERAAEIRDQLHYIEVTVEKQKIISNDKTPRDLFNFYLDKGWLSIQVFFIRQARLMKREKRLFPVVDTAEEEMTSFILQFYNRRNKLLPKEILLPEGLPNQEIEEILGVPVRTPQRGEKRDLLDMAKENAILSLNEKFRLLEMDRQKTTGAMKEITDELGLPTGHVIEAFDHSHIQGADPVSAMVVFVNGEPAKKLYRKYKLTTVVDHADEAASTREVIFRRYSRLLKEEKPMPDMIMMDGGPIQMEAAKDVLENQLGLNIPVIGMVKNDKHQTADLLYGDDAHHVNLDPRSQGFYLVQRIQDEVHRFAITYHRKVHTKHSLSSRLDEIHGVGPRTRNKLLKAFGSINKIAVAPVEEIRALGINQTTAQLIKVSLQGQAEVKKGSSHD
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
B2GBC9
Q68XS9
NDK_RICTY
Nucleoside-2-P kinase
typhus group
MTIQYTFSMIKPDVIKRNKIGQVNTYLENAGLKIVAQKMKFLTKYEAECFYDEHRARPFFNSLVEYITSGAVVLQVLKGEDAITLNRIIMGATNPAEAKEGTIRKDLGESIEANSIHGSDSENSAKREIKFFFSKSEIIE
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Q68XS9
B7MIL6
HSCA_ECO45
Hsc66
Escherichia
MALLQISEPGLSAAPHQRRLAAGIDLGTTNSLVATVRSGQAETLADHEGRHLLPSVVHYQQQGHSVGYDARTNAALDTANTISSVKRLMGRSLADIQQRYPHLPYQFQASENGLPMIETAAGLLNPVRVSADILKALAARATEALAGELDGVVITVPAYFDDAQRQGTKDAARLAGLHVLRLLNEPTAAAIAYGLDSGQEGVIAVYDLGGGTFDISILRLSRGVFEVLATGGDSALGGDDFDHLLADYIREQAGIPDRSDNRVQRELLDAAIAAKIALSDADSVTVNVAGWQGEISREQFNELIAPLVKRTLLACRRALKDAGVEADEVLEVVMVGGSTRVPLVRERVGEFFGRPPLTSIDPDKVVAIGAAIQADILVGNKPDSEMLLLDVIPLSLGLETMGGLVEKVIPRNTTIPVARAQDFTTFKDGQTAMSIHVMQGERELVQDCRSLARFALRGIPALPAGGAHIRVTFQVDADGLLSVTAMEKSTGVEASIQVKPSYGLTDSEIASMIKDSMSYAEQDVKARMLAEQKVEAARVLESLHGALAADAALLSAAERQVIDDAAAHLSEVAQGDDVDAIEQAIKNVDKQTQDFAARRMDQSVRRALKGHSVDEV
Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU.
B7MIL6
Q5HPP5
MUTS_STAEQ
DNA mismatch repair protein MutS
Staphylococcus
MANITPMMQQYLKIKSEYDDCLLFFRLGDFYEMFFDDAKEASRVLEITLTKRDAKKENPIPMCGVPYHSADNYIETLINKGYKVAICEQMEDPKQTKGMVRREVVRIITPGTVMDQNGMDEKKNNYILSFIENEEFGLCYCDVSTGELKVTHFKDTATLLNEITTINPNEIVIKQALSEELKRQINMITETITVREDISDEDYDMNQLTHQLMHDTTQLLLDYIHHTQKRDLSHIEEVIEYAAVDYMKMDYYAKRNLELTESIRLKSKKGTLLWLMDETKTPMGARRLKQWIDRPLINKQQINDRLNIVEEFMDRFIERDTLRNHLNQVYDIERLVGRVSYGNVNARDLIQLKHSISEIPHIKALLNELGAQTTTQFKELEPLDDLLQILEESLVEEPPISIKDGGLFKNGFNAQLDEYLEASKNGKTWLAELQAKERERTGIKSLKISFNKVFGYFIEITRANLNNFQPEAFGYNRKQTLSNAERFITDELKEKEDIILGAEDKAVELEYELFVKLREHIKTYTERLQKQAKIISELDCLQSFAEIAQKYNYVKPTFSDDKVLHLENSRHPVVERVMDYNDYVPNDCHLDDETFIYLITGPNMSGKSTYMRQVAIISIMAQMGAYVPCDSATLPIFDQIFTRIGAADDLVSGKSTFMVEMLEAQKALTYATENSLIIFDEIGRGTSTYDGLALAQAMIEYVAQTSHAKTLFSTHYHELTSLDQMLKCLKNVHVAANEYQGELIFLHKVKDGAVDDSYGIQVAKLADLPNEVIDRAQVILNAFEQKPSYQLSHENTDNQQTVPSYNDFGRTEEEQSVIETHTSNHNYEQATFDLFDGYNQQSEVECQIRELNLSNMTPLEALIKLNELQSQLK
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
Q5HPP5
Q8X610
METAS_ECO57
Homoserine transsuccinylase
Escherichia
MPIRVPDELPAVNFLREENVFVMTTSRASGQEIRPLKVLILNLMPKKIETENQFLRLLSNSPLQVDIQLLRIDSRESRNTPAEHLNNFYCNFEDIQEQNFDGLIVTGAPLGLVEFNDVAYWPQIKQVLEWSKDHVTSTLFVCWAVQAALNILYGIPKQTRTDKLSGVYEHHILHPHALLTRGFDDSFLAPHSRYADFPAALIRDYTDLEILAETEEGDAYLFASKDKRIAFVTGHPEYDAQTLAQEYFRDVEAGLDPEVPYNYFPHNDPQNKPRASWRSHGNLLFTNWLNYYVYQITPYDLRHMNPTLD
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
Q8X610
Q3MBA3
LEU1_TRIV2
Alpha-isopropylmalate synthase
Trichormus
MTTKPERIIIFDTTLRDGEQCPGATLNIDEKLAIAKQLARLGVDIIEAGFAFASPGDFEAVHKIAQTVGTENGPVICSLARARHDDIKAAAEAIKPAAKGRIHTFIATSDIHLQYKLKKTRPEVIAIAEEMVAYAKSFTDDVEFSPEDAGRSDPEFLYQVLERAIAAGATTINIPDTVGYTTPSEFGAIIKGIKENVPNIDQAIISVHGHNDLGLAVANFLEAVKNGARQLECTINGIGERAGNAALEELVMAMHVRRQYFNPFLGRHPDSEEPLTNIDTKQIYKTSRLVSNLTGMLVQPNKAIVGANAFAHESGIHQDGVLKNKLTYEIMDAQLIGLTDNQIVLGKHSGRNAFRTRLKELGFELSETELNKAFVKFKEVADKKKEISDWDLEAIVNDEIQQAPDLFRVELVQVSCGSNARPTATVTLRTPDGEELTDAAIGTGPVDAVYKAINRVVNVPNQLIEFSVQSVTAGIDAIGEVTIRLRYESRVFSGHAANTDIIVASAQAYVNALNRLYASLQTQDKQTEVTA
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Q3MBA3
Q6NRH7
CIPC_XENLA
CLOCK-interacting circadian protein
Xenopus
MEKNQKCATEQERFKARSGHGDGQRAEPRKTQTTTESDKDSGYSDVASECLSSVEQTDTEEGPTTSRWNVALKPSGKTPSQPQSLVVLKNLLVDQGSGPEPNASSWAVHPSIQLLQTSPQIVFFPPTVSSSKPSTCRKDTKYLPILKSYTKIAPHPSHRVSNISLPCARKRGPDERPHNQTKRQCSKGHSGSRKGMDAATLLDTGVQQGPVDQNVKESSVSAKNKELDMQLTTQNINSNEKGSRVASLDTQQNLLSAGQQNKSQRFQNTLDILHRSGLLSIAMKTKELARHNQATQSQLEKLQEQVQLYATAMSSNNPHDWQRLQDSLAEVVKGDTEDLSVREMDL
Transcriptional repressor which acts as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. The physiogical relevance of these observations is unsure.
Q6NRH7
Q22038
RHO1_CAEEL
Ras-like GTP-binding protein rhoA
Caenorhabditis
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPDVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVRHFCPNVPIILVGNKRDLRSDPQTVRELAKMKQEPVKPEQGRAIAEQIGAFAYLECSAKTKDGIREVFEKATQAALQQKKKKKSKCMIL
Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation . Also required for ventral migration of P cells during larval development . Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development . In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology . In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89 . Association with the oxidase bli-3 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity .
Q22038
B7H2Y1
PQQD_ACIB3
Pyrroloquinoline quinone biosynthesis protein D
Acinetobacter calcoaceticus/baumannii complex
MNKEQFDVNLVPTWRQGYRFQFEPAQNGFVILYPEGMIKLNESAGAIGQYIDGTNNVSAIIAQLKQQFGDIPEIDNDVIDYMLVAQQQHWIDLV
Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
B7H2Y1
Q03VG1
RNY_LEUMM
Ribonuclease Y
Leuconostoc
MVVTIISVFFAIVIGLGIGYYVRKSQDAHKVISAEQMATNILEQANNEAKSLKRAAEVDAKDLAQTYRNQVNDSYNDRQKHLQQQEQRLEDRINNLDKKDAALNQRDASLIQKENQVQTRLDDADKKEVLAQKLLTTQQDKLEEIAQLSPDEAKKQILSETKASLTRQRAALIKEAEEEATSEAEKRARNIIVQAIQRSSADSVADVTVSVVNLPSEDMKGRIIGREGRNIRTLESLTGIDLIIDDTPESVVLSGFDPVRREIAKMALDALVADGRINPSRIEEMVEKSRRQMDETIREKGEQAVFELGLRGMHPDLIKMIGRMNYRTSYGQNVLQHSIEVAKLAGMMAAELKMDVALAKRAGLIHDIGKAVDAEVEGSHVELGVRLAEKFNEKPIVINAIASHHGDVAAISPIAELVAAADAISAARPGARSESLENYVQRLKDLEAIANNNQEVHTAYAIQAGREVRVIVEPTKVTDLQAKVLAHDIKSDVEEKLEYPGHIKVTVIRETRAIDYAH
Endoribonuclease that initiates mRNA decay.
Q03VG1
O81787
PTF2_ARATH
TFIIB-related protein PTF2
Arabidopsis
MRCKRCNGSNFERDEDTGNSYCGGCGTLREYDNYEAQLGGIRGPQGTYIRVGTIGRGSVLDYKDKKIYEANNLIEETTERLNLGNKTEVIKSMISKLTDGEFGQGEWFPILIGACCYAVVREEGKGVLSMEEVAYEVGCDLHQLGPMIKRVVDHLDLELREFDLVGLFTKTVTNSPRLTDVDRDKKEKIIKQGTFLMNCALKWFLSTGRRPMPLVVAVLAFVVQVNGVKVKIDDLAKDASVSLTTCKTRYKELSEKLVKVAEEVGLPWAKDVTVKNVLKHSGTLFALMEAKSMKKRKQGTGKELVRTDGFCVEDLVMDCLSKESMYCYDDDARQDTMSRYFDVEGERQLSLCNYDDNISENQLSTKYNEFEDRVCGGTLAKRSQGSSQSMWQRRSVFGMVSTENWWKGKSELSKRLLLKDLLEKDVGLEALPPSYIKGCVAVERRREKIKAAKLRINAIQHPSDNVSEGALSLELEHSKKKRKKGSEIDWEDLVIQTLVLHNVNEEEIEKGHYKTLLDLHVFNSGEV
Plant-specific TFIIB-related protein that plays important roles in pollen germination and embryogenesis, possibly by regulating gene expression through interaction with TBP2 and the subunits of RNA polymerases. Binds double-stranded DNA in vitro.
O81787
Q46WM4
TATB_CUPPJ
Sec-independent protein translocase protein TatB
Cupriavidus
MIDLGISKLALIGAVALIVIGPERLPRVARTVGALVGRAQRYINDVKAEVSREVELEELRKMRTEFEDAARDVERTIHKEVSEQTQALNEALGGIEPSAESGGGVSDFVPSWHSAHKAHNGRKSWRVKQGARPLWFKRQNNVRVWVQSGAARVKRHRPAAGRARSFFE
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
Q46WM4
Q6GIV9
UPPP_STAAR
Undecaprenyl pyrophosphate phosphatase
Staphylococcus
MFIIELIKGIILGIVEGLTEFAPVSSTGHMILVDDMWLKSSEFLGSQSAFTFKIVIQLGSVFAAAWVFRERFLEILHIGKHKHVEGDNNQQRRSKPRRLNLLHVLVGMVPAGILGLLFDDFIEEHLFSVPTVMIGLFVGAIYMIIADKYSAKVKNPQTVDQISYFQAFVIGISQAVAMWPGFSRSGSTISTGVLMKLNHKAASDFTFIMAVPIMLAASGLSLLKHYQDIQIADIPFYILGFLAAFTVGLIAIKTFLHLINKIKLIPFAIYRIVLVIFIAILYFGFGIGKGI
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q6GIV9
Q0AMK3
RNH2_MARMM
Ribonuclease HII
Maricaulis
MSVTIPQKDNQSLNKAGMGNTVRIAGVDEAGRGPLSGPVVAAAVILDPTRPITGLGDSKALSERRRRELFRLIRANAWVGIGIAEPAEIDRLNILHATMAAMRRAVARLPVRPTLVLVDGNRLPPGLPCPAEAIIKGDAKEACIGAASIIAKTVRDDLMEQAARRFPGYGFEGHKGYPSAAHKAALETSGACPIHRRSYAPVRAALESRFSTNANRCG
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q0AMK3
P53816
PLAT3_HUMAN
Renal carcinoma antigen NY-REN-65
Homo
MRAPIPEPKPGDLIEIFRPFYRHWAIYVGDGYVVHLAPPSEVAGAGAASVMSALTDKAIVKKELLYDVAGSDKYQVNNKHDDKYSPLPCSKIIQRAEELVGQEVLYKLTSENCEHFVNELRYGVARSDQVRDVIIAASVAGMGLAAMSLIGVMFSRNKRQKQ
(Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm . May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection . Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome . May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery . The lipid-modifying enzyme activity is required for this process .
P53816
P09113
SOMA_THUTH
Growth hormone
Thunnus
MDRVFLLLSVLSLGVSSQPITDSQRLFSIAVSRVQHLHLLAQRLFSDFESSLQTEEQRQLNKIFLQDFCNSDYIISPIDKHETQRSSVLKLLSISYRLVESWEFPSRSLSGGSAPRNQISPKLSELKTGIHLLIRANQDGDEMFADSSALQLAPYGNYYQSLGADESLRRSYELLACFKKDMHKVETYLTVAKCRLSPEANCTL
Growth hormone plays an important role in growth control and is involved in the regulation of several anabolic processes. Implicated as an osmoregulatory substance important for seawater adaptation.
P09113
B2GB73
RSMH_LIMF3
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Limosilactobacillus
MAEFNHVTVLLHEAVAGLAIQPAGVYVDATLGGGGHSGEILKQLTSGHLYSFDQDETAIHYNQANLGPAIEEGKLTLMQTNFRNLKQALADQGVTAIDGIVYDLGVSSPQFDDAKRGFSYQHDAPLDMRMNQDQPLSAYQVVNEWSYQELVRILYRYGEEKFAKQIARAIERARQKQPIQTTMELANIVKEAIPAAARRHGGHPAKKSFQAIRIAVNDELGALEDSLEQALALLKVGGRISVITFQSLEDRLVKTMFKEATSLPDLPPGLPVIPADAQPDFKLINKKPVLPTEDELKVNHRAHSAKLRVIERLK
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
B2GB73
Q5R678
IDH3A_PONAB
NAD(+)-specific ICDH subunit alpha
Pongo
MAGPAWISKVSRLLGAFHNPKQVTRGFTGGVQTVTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAACFATIKDGKSLTKDLGGNAKCSDFTEEICRRVKDLD
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.
Q5R678
Q20EW3
PSBF_OLTVI
PSII reaction center subunit VI
Oltmannsiellopsis
MANQKTYTYPIFTVRWLAIHALAVPTVFFLGSITAMQFIER
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Q20EW3
Q9CYH5
GFOD2_MOUSE
Glucose-fructose oxidoreductase domain-containing protein 2
Mus
MKLLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQLAEEMNITFYTSRTDDVLLHQDVDLVCINIPPPLTRQISVKALGIGKNVVCEKAATSMDAFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLIAEHYVGAVMICDARIYSGSLLSPSYGWICDELMGGGGLHTMGTYIVDLLTHLTGQKAEKVHGLLKTFVRQNATIRGIRHVTSDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSAAQEELLVRDSLAVGAGLPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSMAASFEDGLYMQSVVDAIKRSSRSGEWETVEMLAEEPDANQNLSETLQRNNL
Promotes matrix assembly.
Q9CYH5
Q9KPB6
ACPS_VIBCH
4'-phosphopantetheinyl transferase AcpS
Vibrio
MIVGLGTDIAEIERVEKALARSGENFARRILTDSELEQFHASKQQGRFLAKRFAAKEAASKALGTGIAQGVTFHDFTISHDKLGKPLLILSGQAAELASQLQVENIHLSISDERHYAMATVILERR
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
Q9KPB6
P30722
DNAK_DIALT
Heat shock protein 70
Diacronema
MAKVVGIDLGTTNSVVAVMEGGKPTVITNSEGGTTTPSVVAYAKNGDLLVGQIAKRQAVINSENTFYSVKRFIGRPSKEVSDELRQTPYKIEDSEGKIRLKCPNLNKNFAAEEISAQVLRKLVNDANKYLGEKVEKAVITVPAYFNDSQRQATKDAGKIAGLEVLRIINEPTAASLAYGLDKKDNETILVFDLGGGTFDVSILEVGDGVFEVLSTSGDTRLGGDDFDEKIVKWLLNEFEKEEKFSLKGDSQALQRLTEAAEKAKIELSSLSQTEINLPFITANENGAKHIEKTLTGEKFESLCSDLFDRCRIPVENALKDAKLKPNQIDEVVLVGGSTRIPAVKKLVKDILGKEPNETVNPDEVVAIGAAIQAGVLSGEVKDILLLDVTPLSLGVETLGGVTTKIIPRNTTVPTKKSEIFSTAVDNQPNVEIHVLQGEREFARDNKSLGTFRLDGILPAPRGIPQIEVTFDIDANGILSVTAQDKGTSKQQSITISGASTLPKEEVEKMVKEAEQNAAADKEKGENIRVKNEADLYCYQAEKQISELPEALVNENQSLIKESKETVEMLKENIKKEDYDKIKENLKKLQEKLMEIGQKAYAKKEPLKDEDSNKAGSQDDFIDADFTESK
Acts as a chaperone.
P30722
Q9H4B0
OSGL1_HUMAN
tRNA threonylcarbamoyladenosine biosynthesis protein OSGEPL1
Homo
MLILTKTAGVFFKPSKRKVYEFLRSFNFHPGTLFLHKIVLGIETSCDDTAAAVVDETGNVLGEAIHSQTEVHLKTGGIVPPAAQQLHRENIQRIVQEALSASGVSPSDLSAIATTIKPGLALSLGVGLSFSLQLVGQLKKPFIPIHHMEAHALTIRLTNKVEFPFLVLLISGGHCLLALVQGVSDFLLLGKSLDIAPGDMLDKVARRLSLIKHPECSTMSGGKAIEHLAKQGNRFHFDIKPPLHHAKNCDFSFTGLQHVTDKIIMKKEKEEGIEKGQILSSAADIAATVQHTMACHLVKRTHRAILFCKQRDLLPQNNAVLVASGGVASNFYIRRALEILTNATQCTLLCPPPRLCTDNGIMIAWNGIERLRAGLGILHDIEGIRYEPKCPLGVDISKEVGEASIKVPQLKMEI
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.
Q9H4B0
P29302
PSAD_NICSY
Photosystem I 20 kDa subunit
Nicotiana
MAMATQASLFTPALSAPKSSAPWKQSLASFSPKQLKSTVSAPRPIRAMAEEAATKEAEAPVGFTPPQLDPNTPSPIFGGSTGGLLRKAQVEEFYVITWESPKEQIFEMPTGGAAIMREGANLLKLARKEQCLALGTRLRSKYKINYRFYRVFPNGEVQYLHPKDGVYPEKVNAGRQGVGQNFRSIGKNKSPIEVKFTGKQVYDL
PsaD can form complexes with ferredoxin and ferredoxin-oxidoreductase in photosystem I (PS I) reaction center. PSAD may encode the ferredoxin-docking protein.
P29302
O70591
PFD2_MOUSE
Prefoldin subunit 2
Mus
MADSSGRVGKSGGSGAGKGAVSAEQVIAGFNRLRQEQRGLASKAAELEMELNEHSLVIDTLKEVDETRKCYRMVGGVLVERTVKEVLPALEGNKEQIQKIIETLSQQLQAKGKELNEFREKHNIRLMGEDEKPAAKENSEGAGAKASSAGVLVS
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
O70591
P08824
RUBA_RICCO
CPN-60 alpha
Ricinus
RTALQSGIDKLADAVGLTLGPRGRNVVLDEFGSPKVVNEGVTIARAIELPDPMENAGAALIREVASKTNDSAGDGTTTASVLAREIIKLGLLSVTSGANPVSIKRGIDKTVQGLIEELEKKARPVKGRDDIKAVASISAGNDELIGTMIADAIDKVGPDGVLSIESSSSFETTVEVEEGMEIDRGYISPQFVTNPEKLICEFENARVLVTDQKITAIKDIIPLLEKTTQLRAPLLIIAEDVTGEALATLVVNKMRGILNVAAIKAPGFGERRKALLQDIAILTGAEFQASDLGLLVENTSVEQLGIARKVTITKDSTTLIADAASKDELQARIAQLKRELAETDSVYDSEKLAERIAKLSGGVAVIKVGAATETELEDRKLRIEDAKNATFAAIEEGIVPGGGAALVHLSTVVPAINGEDKDADERLGADILQKALVAPASLIAQNAGIEGEVVVEKVKAREWEIGYNAMTDKYENLVEAGVIDPAKVTRCALQN
This protein binds RuBisCO small and large subunits and is implicated in the assembly of the enzyme oligomer.
P08824
A8AUL5
G6PI_STRGC
Phosphohexose isomerase
Streptococcus
MPHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSDFLGWLDLPENYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFANLQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFKELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWETFVVPDDIGGRFSVLTAVGLLPIAASGADIKALMEGANAARKDYTSDKLSENEAYQYAAVRNILYRKGYATEILVNYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDKPRKNVIIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAFTLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
A8AUL5
Q2NU30
LPOB_SODGM
Penicillin-binding protein activator LpoB
Sodalis
MKKRALIVLAALVLASCTSRKPASPPAPIEPVPPPVTVSVQPPPPATSEPVPMPPKIKTIDWQASLSPLVQQMLAVEGINDGSVLLVNTMKNTTNGSVQTGKATAALTRLITDAGGKFQVVGANQLNAARQMLGLSADDSLESRSKAVGLARYLNAQYVLYSAAAGDVKQPTLDLQLMLVQTGEIIWSGNGVAQD
Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).
Q2NU30
B2V1V3
RNPA_CLOBA
Protein C5
Clostridium
MIYRLKKNIEFIIVYRRGKSFANKTLVLYVLKNKRNKDKDGIAYSKVGISVSKKVGNSVVRSKCKRLLSESFRLNYNNILKGYDCVFVARNPMRDSDYFETEKAMKNLIKKAGLYYDEENGIKSN
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
B2V1V3
F4IHY7
PTA12_ARATH
Protein HEMERA
Arabidopsis
MASISTTTWLYRGQVCTDSGKSSNCIVQRRVKCGFPLKTLHAGITSRDRSLRHCIKCKKEDGDGDVSEGSKKSEEGFEYVTVERHPYHSYMDSTSGKLEPASGARASIPGEDYWPEGTSSRVRAARAPQPAGESSSFPSYGKNPGSRRKKNRKATEENVTVETNDEVSDSEDSSEEEENDSSDGFVTYKNEFEREEEETGFELDKKLGRPHPFIDPTKKKQIEKTLTSDESWWNWRKPEKEQWSRWQRRRPDVETVFLKAMAETGQVKLYGEEPTLTETSLYRARRHLFKEERLQAERERLAKEGPMAFYSEWVKAWKRDTSREAVQKHFEETGEDENTQLIEMFSHQTDREYRIMMGTDIRIKRDPLAMRMREDQIKQIWGGDPVYPTINYIQDPNAVMDFRGPDFHEPTPNMLSYLKENGKVISREMHEALLTKEKTEQLEVPDMDDAMAQAVDIGENDDDEDDADVEKDDEKVPRNWSVLKETPELRTAKPKPKKEGRMSLDEAVDDAENLTDFLMDFEEETDP
Involved in plastid gene expression . Required in the nucleus for the initiation of photomorphogenesis mediated by phytochromes (PHYs) (e.g. PHYA and PHYB) by mediating PHYs localization to photobodies, especially in response to red and far-red light, and implicating phytochrome nuclear bodies as sites of proteolysis for PHYs and PIFs proteins (e.g. PIF1 and PIF3). Acts downstream of PHYs and upstream of DET1 .
F4IHY7
P45738
RBL_HELAN
Ribulose bisphosphate carboxylase large chain
Helianthus
MSPQTETKASVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYGLEPVPGEDNQFIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYVKTFDGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRACYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKAQAETGEIKGHYLNATAGNCEDMMKRAVFARELGVPIVMHDYLTGGFTANTSLSQYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRMSGGDHIHSGTVVGKLEGEREITLGFVDLLRDDFIEKDRSRGIYFTQDWVSLPGVLPVASGGIHVWHMPALTEIFGDDSVLQFGGGTLGHPWGNAPGAVANRVALEACVQARNEGRDLATEGNEIIREATKWSPELAAACEVWKEIKFEFQAMDTLDTDKDKDKKR
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
P45738
Q57M77
UBIG_SALCH
3-demethylubiquinone 3-O-methyltransferase
Salmonella
MNTEKPSVAHNVDHNEIAKFEAVASRWWDLEGEFKPLHRINPLRLGYITERSGGLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGIEVEYMQETVEEHAAKHAQQYDVVTCMEMLEHVPDPQSVVHACAQLVKPGGEVFFSTLNRNGKSWLMAVVGAEYILRMVPKGTHDVKKFIKPAELLSWVDETVLKEQHITGLHYNPITNTFKLGPGVDVNYMLHTRAKKA
O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.
Q57M77
F1QMB9
CCNK_DANRE
Cyclin-K
Danio
MKDGKENSNATFGSFTTNLDHTKPCWYWDKKDLAHTPSQSDLDPATEARYRREGARFIFDVGTRLGLHYDTLATGITYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFAQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLRYAKQLKGDKNKVQKLVQMAWTFVNDSLCTMLSLQWEPEIIAVAVMYLAGRLCKFDIQEWTSKQSSRRWWEQFVQDVPVELLEDICHQILDLYSQGKQPIPQQPPMQDKEKPPPPPAAPPGQSGAQNPPAQPPSKKNSPQASPPAKIKRQHVSPKDEPKAPAEQVGSKIPRLESPMPPLPVSQPPERKTPSAIPAPPAEAEPAAASELDPAQGPAPPLPHGAPPPLPHRPPPTEFGGPCSDFLSSVKHKRRYLDDDRNL
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
F1QMB9
Q8G5Q9
CLPP2_BIFLO
Endopeptidase Clp 2
Bifidobacterium
MSNTFATLPVMAGDDVPAGPVDPIFNRLLKDRIIWMGEEVKDDMANRICAQLLMLAAEDPKKDIWLYINSPGGSITAGMAIYDTMQLIEPDVATVGLGMCASMGQFLLSSGTKGKRYLTSHARVLMHQPSGGIGGTATDVRINAELIMDMKKTMSELTAEQTGHTLEEIYRDNEYDHWFTAQEALDYGFVDKLVTTPDTIGNNQQGE
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q8G5Q9