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2.75k
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5.51k
AlphaFoldDB
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Q47453
PCOB_ECOLX
Copper resistance protein B
Escherichia
MKRNLKAIPVLVAGLFTSQLSIAAGSVSADPHAGHDMSAMQMPADENFTEMTSMEPIVTESRTPIPPVTDADRKAAFGNLQGHAIHDSAINYLVLLDQLEWQRSDNTNNFSWSVNSWIGGDTDRIWLKSEGERSNGETEAAEAQLLWGHAVGPWWDLVAGVRQDFRPASARTWAAVGFQGLALYNFESEITGFVSNGGKAALRLGGEYDVLLTNRLILQPSYEVNFYSQDDESRGRGRGLTDTELGLRLRYEIRREFAPYIGVSWNQLYGKTSDMAKREGEKDHQVVFLAGARIWF
Required for the copper-inducible expression of copper resistance.
Q47453
Q7VKF6
RS11_HAEDU
30S ribosomal protein S11
Haemophilus
MAKTPVRARKRVKKQIADGVAHIHASFNNTIVTITDRQGNALAWATAGGSGFRGSRKSTPFAAQVAAERCAEAVKEFGLKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Q7VKF6
P61514
RL37A_MOUSE
60S ribosomal protein L37a
Mus
MAKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRAVGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
P61514
A6QLF8
TM108_BOVIN
Retrolinkin
Bos
MKRSLQALYCQLLSFLLTLALTEALVFAAQEPSPRESLQVSPSGTIPGTMVTASLSSTRHSSMVATPASVVTPTPHPDGPSSQATAPMATTTPHLDGHPPTNTISTIMATASTPHSEGSLSTGPLPAAMATTSSHSEGRAPGETAPTILLTKPGEATSRPPTAPSRATIRRPPRPPGSSRKGAGSSPRPIPAAPSGHAGRKDGQRGRNQSSTHLGQKRPLGKIFQIYKGNFTGSVEPDPSTFTPRNPLWGYSSSPQPQTVAATSAPSRTSWVPPTTPLVPVEDKPSLSRADQGGGSTFTSQGGEPDATAASGTPASQQRAPVPSQRPHGDPQDGSSHSDSWLTVTPGTSRPPSTNSGVFAATTGPIQAAFDASVSVPSEGLPQGTSLAPQAPAHPTWASESTVSQAEEKAVATPTPTMMGRVPSPLSTVVSTATGNFLNRLVPAGTWKPGTAGNISHVAEGDKPQQRATICLSKMDIAWVILAISVPISSCSVLLTVCCLRRKKKPANPENSLSYWNNAITMDYFSKHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI
Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
A6QLF8
Q8BUY8
GASP2_MOUSE
G-protein coupled receptor-associated sorting protein 2
Mus
MTGAEVETGSQAKPDKKPQEEVAGGAERESEAPLVVRPKVRPQAPATSGARPKTETKSSSRARPKTETQSVSGTRHRMSGARPRSEAQLMSGARPKTDARAVGGARPKTEAKPIPGARPKGDAQAWAHSEFGAEAMPRAERAHLSNSVTWPPVNVGSATVTKSKSLSMNTELASMGSEIFSGTQGQPGIEPWFGPREEANMGSWCYPRPRAREETSNESADENSTMSSFWTREETSIRSWPREEVNTRSRHRAKHQTNARSKPRSKQDPYIDSLSGSEDEASNPFCFWAGENTNDMFRARGRDEANARPKIRTKREDYFEDEDEIYKESWLLPGEEGNRFRRRDKEEPNKTLKNENEKDVKNDETVEQESRLEEEVIIGSWFWAEQETNVEAGASAICDAEPGAEEGAIGGSLFWTEEKPSLGAVARDEVRPESEEEALFGSWFWDRDEACFDPNPTPVYTAKSRYRDPEEDLNLASRPKTWDEVTIEFKPPCHGLGFPSPRPFIIPEGASGNSEEKAKNAELGAEGEEQDSVAQRDLPEPEFPFQYDPSYRSVQEIREHLKARESAQPENWSCTCIQCELRISSAEFEELLLLMDRIRDPFIHEIAKIAMGMRTASQFTRDFIRDSGVVSLIEALMNYPSSRVRTNFLENMVHMAPPYPNLNMIETFICQVCEETLSHSVNSPEQLTGMRMLRHLTITTDYHVLIANYVSGFLALLTTGDARTKFHVLKMLLNLSDNPMVAKKLFSAKALSIFVGLFNIEETNDNIQIVIKMFQNISNIVKSGAMSLLDDDFSLEPLVSAFHEFEELAKQLQIQIDNQNDPEEGQ
May play a role in regulation of a variety of G-protein coupled receptors.
Q8BUY8
Q31AA3
APT_PROM9
Adenine phosphoribosyltransferase
Prochlorococcus
MEKLEKLISTYENYPKAGVSFKDVIEIVQHPSIFRQLILEMAKSKIIKEAEALISIDARGFIFGSAISIQAAKPMIVARKPGKLPGELVTKKYSLEYGENSLSIQKKALKKYNSFAIIDDLLATGGTVNCVSELINNNNKKVVGLLVVAELSKFDGRSRFNFPVESSILF
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
Q31AA3
B7NHE2
CAIB_ECO7I
Crotonobetainyl-CoA:carnitine CoA-transferase
Escherichia
MDHLPMPKFGPLAGLRVVFSGIEIAGPFAGQMFAEWGAEVIWIENVAWADTIRVQPNYPQLSRRNLHALSLNIFKDEGREAFLKLMETTDIFIEASKGPAFARRGITDEVLWQHNPKLVIAHLSGFGQYGTEEYTNLPAYNTIAQAFSGYLIQNGDVDQPMPAFPYTADYFSGLTATTAALAALHKVRETGKGESIDIAMYEVMLRMGQYFMMDYFNGGEMCPRMTKGKDPYYAGCGLYKCADGYIVMELVGITQIAECFKDIGLAHLLGTPEIPEGTQLIHRIECPYGPLVEEKLDAWLAAHTIAEVKERFAELNIACAKVLTVPELESNPQYVARESITQWQTMDGRTCKGPNIMPKFKNNPGQIWRGMPSHGMDTAAILKNIGYSENDIQELVSKGLAKVED
Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
B7NHE2
B8G6L3
NUON_CHLAD
NDH-1 subunit N
Chloroflexus
MDSLTIPPVDLRLLAPLLVVVTWATVLLLVDVFFIPDGRKKLTGYLAIGGLVVAGLVGLPLWGVTGTTFGGMLRLDPFALTLTWIFLLIGILSITMSLDYLPGQGIEQGEYYPLIMFAVSGMILLAQGTDLIVLFLGIETLSITLYILTGFAYPRLTSEEAAMKYLVLGAFAAGFFVYGIALIFGATGSTRLGEIGAYAASRGIGDLNLTLLLGGAAMVLIAFSFKVALAPFHMWTPDVYEGSPTPVAAFMSVGTKGGALAALVRLLFEGLPTLNEYWLPVLAGLTALTMVVGNLGAVAQTNVKRMLAYSSIGHAGYVMLGVMVAGEQRGPEAFLFYMLVYALSNLGAFAVLIALEHQGENAWRLDDFAGLYQRQPLLAVAMAIFMFSLAGVPPMAGFMAKFYALTAAWEGGLPWLALVGVVTSAIAAFFYLRVIIRMFMTEPEGEPTPTLNRGLTVDIALAAIGTIAIGLIPAPVFALVERSLVVLGG
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
B8G6L3
Q8NPB7
AFTC_CORGL
Arabinofuranosyltransferase C
Corynebacterium
MSFSPVAPSISAPTPRRSRWDSIGNAVAWPLAMLLMAHRFFVLAINGAVTDDFTTVYSALRRFVEGIPVYNEVYHFVDPHYLYNPGATLLLAPLGYITHFTLARWMFIAVNLLAIVLAFGLLTRLSGWALRSMVWPIAIALAMLTETVQNTLIFSNINGILLLMLAIFLWCVVHKKSWLGGLVIGLAILIKPMFLPLLFLPLVKKQWGSLILGILTPVIFNAVAWFLVPGASEYVTRTMPYLGETRDFANSSLPGLAIYFGMPTWMEITWFLIFGAMVGLAVLALLRFRNTEPYFWAATTTGVLLTGVFFLSSLGQMYYSMMIFPMIFTLLGSRSVFHNWVAWVAAYFFLSPDTFTSQRLPDVARWMEFFSATVGWGLLIVVTFVSALIWFIGDIRAKGTPSSPITTDPTHDHLERTA
Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the corynebacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
Q8NPB7
Q64332
SYN2_MOUSE
Synapsin II
Mus
MMNFLRRRLSDSSFIANLPNGYMTDLQRPEPQQPPPAPGPGAATASAATSAASPGPERRPPPAQAPAPQPAPQPAPTPSVGSSFFSSLSQAVKQTAASAGLVDAPAPSAASRKAKVLLVVDEPHTDWAKCFRGKKILGDYDIKVEQAEFSELNLVAHADGTYAVDMQVLRNGTKVVRSFRPDFVLIRQHAFGMAENEDFRHLVIGMQYAGLPSINSLESIYNFCDKPWVFAQMVAIFKTLGGEKFPLIEQTYYPNHREMLTLPTFPVVVKIGHAHSGMGKVKVENHYDFQDIASVVALTQTYATAEPFIDAKYDIRVQKIGNNYKAYMRTSISGNWKTNTGSAMLEQIAMSDRYKLWVDACSEMFGGLDICAVKAVHGKDGKDYIFEVMDCSMPLIGEHQVEDRQLITDLVISKMNQLLSRTPALSPQRPLTTQQPQSGTLKEPDSSKTPPQRPPPQGGPGQPQGMQPPGKVLPPRRLPSGPSLPSSSSSSSSSSSSSSAPQRPGGPTTTHGDASSSSNSLAEAQAPQAAPAQKPQPHPQLNKSQSLTNAFSFSESSFFRSSANEDEAKAETIRSLRKSFASLFSD
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons.
Q64332
P11747
TAF13_YEAST
TBP-associated factor 19 kDa
Saccharomyces
MSRKLKKTNLFNKDVSSLLYAYGDVPQPLQATVQCLDELVSGYLVDVCTNAFHTAQNSQRNKLRLEDFKFALRKDPIKLGRAEELIATNKLITEAKKQFNETDNQNSLKRYREEDEEGDEMEEDEDEQQVTDDDEEAAGRNSAKQSTDSKATKIRKQGPKNLKKTKK
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
P11747
Q92H59
MURE_RICCN
UDP-N-acetylmuramyl-tripeptide synthetase
spotted fever group
MSHNLKQLFQQHNVKGLSINSKTVKDKDIFFAIKGQNTDGNDFIKDALSKGAVLVITDNKKNIVIDKVIYVKDVQAALYEAIEIFYPKKPKDLIAVTGTNGKSSVVSYIAQTYSLLGKKAASIGTIGVEIFGCVNLINDVPELTTLDYLSFRKIAHNLAENGIEYLVFEASSHGLDQARLREIKVNIACFTSFSQDHLDYHHTKENYLLAKLKLFINHLLPNGIAILNSDIEEIEFVKDYLHNHNIKFITVGTKGDLEITRLNGSLKGQNINFTFNNREYNFNTPIIGSFQASNLLIAVLSIHYIGFAFDDVIDSLVEVKAVKGRMERIDNTNIFVDYAHTPDALEKALTELKNIKLRDSKLSVVFGCGGNRDKAKRSLMGQIAAKRADTIIITDDNPRHEDPKLIRAEIISGIEKADYTEIANREEAIKYGINNLKQDDILLVAGKGHENYQIIGDKKLPFDDAEVVRKCVKVCHPVA
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Q92H59
Q866N2
MYOC_RABIT
Myocilin 35 kDa N-terminal fragment
Oryctolagus
MPAVQLLLLAGLVWGAGARTAQLRKANDRSGRCQYTFSVASPSESSCPEQGQTMSAIQDLQRDSSTQRADLESTKARLSSLESLLHRLTLAQTSGPQEIQEELQKELGTLRRERDQLESQTRELEAAYSNLLRDKSALEEEKRRLMQENEDLARRLESSSQEVARLARGQCPQARDTSQDVPAGSREASQWNLDTLAFQELKSELTEVPASRILKENPPVLPRGEEGDNGCGELVWVGQPVTLRTAETITGKYGVWMRDPKPTSPHTQETTWRIDTVGTDIRQVFEYDRISQFVQGYPSKVYVLPRSLESTGAVVYAGSLYFQGAGSRTVIRFELNTETVKAEKEIPGAGYRGQFPYSWGGYTDIDLAVDETGLWVIYSTEEARGAIVLSKLNPENLELEKTWETNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGISKPLAIPFKNRYKYSSMIDYNPLERKLFAWDSFNMVTYDIKLSKI
Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.
Q866N2
Q8UIH2
RS20_AGRFC
30S ribosomal protein S20
Agrobacterium tumefaciens complex
MANTTSAKKATRKIARRTAVNKARRSRVRGFIRKVEEAIATGDLAVATEALKAAQPEIQRAATRGVLHGNTASRKVSRLAQRVKALSA
Binds directly to 16S ribosomal RNA.
Q8UIH2
B9E8I0
LUXS_MACCJ
Autoinducer-2 production protein LuxS
Macrococcus
MTKKMNVESFNLDHTIVDAPFVRLAGIKEGINGDVIHKYDIRFKQPNKEHMEMPALHSLEHLMAENIRNHTDKVVDISPMGCQTGFYVSLINHDNYEDVLAILEKTLNDVLAADEVPACNEVQCGWAASHSLEGAKAIAQEMLSKKDSWHVIYQPGKEPQA
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).
B9E8I0
A1VCE6
KTHY_DESVV
dTMP kinase
Desulfovibrio
MFITFEGIEGSGKSTALQGLAAWLQQHGHGVAVTREPGGSRLGRTLRSILLDLGNTDITPEAELFLYLADRAQHVAQVVRPALDEGMVVLSDRYADSTVVYQGYGRGLDPMMLRQFNDVAVGGLWPDLTILLDLEPEAGLNRALARNIREGMHAAEGRFEAESLAFHTRVREGYLTWAALHGGRYRVVDATQSPEDVVRDVVGIVAAALGDVSSGEAVSGRTGA
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
A1VCE6
Q8VUP4
REX_STRSU
Redox-sensing transcriptional repressor Rex
Streptococcus
ASSKEIAEAIGIDSATVRRDFSYFGELGRRGFGYNVKELMDFFADILNDTSITNVMLVGVGNMGRALLHYRFHERNKMKIVMAFEADDNPAVGTTDENIPIHAISEIKERISEANSQTAILTVPSVKAQEVTDILVEAGVKGILSFSPVNLSVPKDVVVQYVDLTSELQTLLYFMRKG
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
Q8VUP4
Q126S5
PDXH_POLSJ
Pyridoxal 5'-phosphate synthase
unclassified Polaromonas
MSNPIIDIAALRKSYERAELNEDASHADPLKQFDQWLNEAIAAQVPEPNAMTLATVDSKLRPSTRVVLVKGYDARGIVWFTNYNSRKGLELAGNPYAALQFHWVELERVVRIEGVVEKVSAEESDAYFNSRPLDSRIGAWASPQSEVIASRSVLVTNAAKYGAKFLLQPPRPPHWGGYRLQPDNWQFWQGRKSRLHDRLRYTLQADSSWLRERLAP
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Q126S5
Q9S219
NADK2_STRCO
ATP-dependent NAD kinase 2
Streptomyces albidoflavus group
MTQNRVRTVFLLAHTGRPAAIRSAELVVKGLLRAGIGVRVLEAEARDLPLPGEVELVGEATPQCLDGCELLIVLGGDGTLLRGAEFARASGVPMLGVNLGRVGFLAEAERDDLDKVVDRVVNRAYEVEERMTVDVVVHRNGDIVHTDWALNEAAVQKAGAEKLLEVVLEIDGRPVTGFGCDGIVLSTPTGSTAYAFSAGGPVVWPEVEALLMVPISAHALFAKPLVTSPDSVLAVEVLPHVPPGVLWCDGRRTVELPPGARVEVRRGAVPVRLARLHHASFTDRLVAKFALPVSGWRGAPH
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Q9S219
C1FZ35
CYNS_PARBD
Cyanate lyase
Paracoccidioides
MSNINLATLDISEHPNLPSSSAVLFEAKAKKKLSFEAIASAIGRNEVATAAIFYGQAKASAEDIVKLSEVLGIDHLYLESLLSGFPDRGKSMTFPPKDPLIYRLFEIVQNYGYAYKAVMNEKFGDGIMSAISFSTKVEKETDLDGNNWAVVTWRGKWLPYSRF
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
C1FZ35
A7MMV9
ATPL_CROS8
Lipid-binding protein
Cronobacter
MENLNMDLLYMAAAVMMGLAAIGAAIGIGILGGKFLEGAARQPDLIPLLRTQFFIVMGLVDAIPMIAVGLGLYVMFAVA
Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
A7MMV9
P45985
MP2K4_HUMAN
c-Jun N-terminal kinase kinase 1
Homo
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to pro-inflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.
P45985
Q62835
RABE2_RAT
Rabaptin-5beta
Rattus
MAAAPAALALDPQPQEEQKDASESSELSRLRAELAGALAEMETMKAVAEVSESTKAEAVAAVQRQCQEEVASLQAILKDSISSYETQIAALKQERQQQQQDSEEKERELGHLKQLLARAHPLDSLEKQMEKAHEDSEKLREIVLPMEQEIAELKVKLLRAEELIQEIQRRPRQPASLHGSTELLPLSRNPSPPLEPSEEPSGDAGPAAEAFAHNCDDSASISSFSLGGAAGSVSLRGPQGLSPEQEETASLVSTGTLVPEGIYLPPPGYQLVPDSQWEQLQVEGRQLQKELESVRRERDELQEGLSRSNEDCAKQMQVLLAQVQNSEQLLRTLQGTVSQAQERVQRQMAELATSHKCLSQEVKRLNEENRGLRAEQLPSSALQGSEQQEDQDEALPSSIQELHQLVRHTRQQARARQQAQEHEAERLRIEIVKLREALDEETAAKASLEGQLRVQREETDVLEASLCSLRIETERVQQEHHKAQLTDLLSEQRAKALRLQAELETSEQVQRDFVRLSQALQVRLEQIRQADTLEQVRSILDEAPLRDIKDIKDS
Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis.
Q62835
Q2LQB1
RS17_SYNAS
30S ribosomal protein S17
Syntrophus
MSERGFNRTIKGVVVSNKMDKTIVIRAERLVKHPVFHKYTRKHVKYMVHDEKNECKVGDTVIVMESRPLSRLKRWRMLRIVAKAE
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
Q2LQB1
F4I0P8
VP35B_ARATH
Vesicle protein sorting 35B
Arabidopsis
MRTLAGVEDEDKWLAEGIAGIQHNAFFMHRALDANNLREVLKYSALMLSELRTSKLSPQKYYDLYMRAFDQLRQLEIFFKDESRHGLPVVDLYELVQHAGNILPRMYLLCTVGSVYIKSKQAPSKDVLKDLVEMCRGVQHPIRGLFLRSYLAQVSRDKLPEIGSDYEGDANTVMDAVEFVLQNFTEMNKLWVRIQHQGPGTVREKQEKERNELRDLVGKNLHVLGQIEGVDLEMYKETVLPRVLEQVVNCKDKLAQYYLMECIIQVFPDEYHLQTLETLLAACTQLMPTVDTKIVLTQLMDRLSNYAASSPDVLHEFLQVEAFAKLSNAIGKVIDTQLEMPIVGAMTLFVSLLTFTLRVHPDRLDYVDQVLGACVVKLSSVPKLEDARAMKQVVALLSAPLEKYSDIVTALTLSNYPRVMDHLDDGTNKVMAMLIIQSIMKTDSCISTADKVEVLFELIKGLIKDLDETNAEELDEEDFQEEQNSVARLIHMLDNEEPEEMLKIICVVRRHLMTGGPRRLPFTVPPLVFSAVRLVRQLESQGGDIAGEDSATPRKIFQILNQTIEVLTSVPCPELALRLYLQCAEAASDCDLEPVAYEFFTQAFMLYEEEIADSKAQVTAIHLIVGTLQRINVFGVENRDTLTHKATGYSARLLKKPDQCRAVYACSHLFWVDDPDGIKDGERVLLCLRRALRIANAAQQMASATRGSSGPVTLFVEILNKYIYFFEKGNPHITPSDIQSLIELINNEMQSDNGNTTIHSDPFFTSTLRYIKFIKQKGGLMGEKYDPIKL
Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. Also involved in the efficient sorting of seed storage proteins globulin 12S and albumin 2S. The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.
F4I0P8
Q11QD4
IF1_CYTH3
Translation initiation factor IF-1
Cytophaga
MSKQSSIEQDGKILEALSNAMFRVELSNGHQVIAHISGKMRMNYIKILPGDKVRMEMSPYDLTKGRIVFRYK
One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.
Q11QD4
Q7W223
LIPB_BORPA
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Bordetella
MIKWLARPADYGSVWDAMKAFTAARGPGTADEIWLCEHAPVYTLGQAGRPEHLLNPGLIPVVHCDRGGQVTYHGPGQVLAYTLFDLRRAGLYVREYVDMLEQATLATLRELGLEQACRKPGAPGIYVPQPGGELAKIAALGVKVRNGYAYHGLALNIDMDLSPFLGINPCGYEGLRTVDLAACGVRTSVERAGELLAAQLARAHGHAVQQRAAALAGVPG
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
Q7W223
A3N0Q6
FDHE_ACTP2
Protein FdhE homolog
Actinobacillus
MSIRILPENEIKQAASSFQNPPLLFANPKNLYFRRAKRLRQLAENNPFGDYLEFAANLSEVQLDLLENHPIANYAEKLTACIEESNGQKPLNAKTFKRSSEWRELLLLLTEKFKPYANDTMLATIELLEKSSTSELEALADDLLNERYEAVGADKAVFLWAALSLYWTQLAQQLPRNTQTEVGERHTCPVCDSAPIVSVVHFGDTQGLRYLHCSLCESEWNMVRSQCSVCDQSGKLDYWSIDSVDAPVKAESCGDCESYLKVLYQEKDPHVEPVADDLGTLFLDAEMEQKGFARSGLNPFLFQVE
Necessary for formate dehydrogenase activity.
A3N0Q6
A7HZK8
RL23_CAMHC
50S ribosomal protein L23
Campylobacter
MADITDIKTILYTEKTLNLQEGGMVVIQTSPKMTKTSLKAVLKEYFGFTPLKINSLRIDGKVKRFRGRLGVRDNFKKFYVKLPEGVSLENVGA
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
A7HZK8
B3CRZ0
RL20_ORITI
50S ribosomal protein L20
Orientia
MSRARSGKVNKNRHKKILKLAKGYRGRAKNCFRIAIQKVEKALQYSYRDRRNRKRQFRALWIQRINAAVRQYDITYSQFINGLKQANITVDRKVMADLAVHNADSFVHLVELTKKSLAKTA
Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.
B3CRZ0
Q9ESJ7
IKBP1_MOUSE
Signaling molecule that associates with the mouse pelle-like kinase
Mus
MSLQPAPASRVFMELVPWADRGRENHPISAAEAQPIGRRPHVAEAHPGAREVHVSGAAEVSASPDRALVTVRVSSTKEVSAEAKKSVCRRLDYITQSLQQQGFQAENVTVTKNIRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPEFYHTPGSVENLRRQACLVAVENAWRKAQEVCDLVGQTLGKPLLIKEEETKDWEGQTDDHQLSRLPGTLTVQQKIKSATIHAASKVFITFEVKGKEKKKKHL
Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity.
Q9ESJ7
Q3AKY6
NDHL_SYNSC
NDH-L
unclassified Synechococcus
MDLSSLLSQIPQDTLLVLLAYTVLGGLYLVVVPLALYAWMNQRWHRMGKLERLGIYGMVFFFFPGMILFAPFLNFRLSGQGDV
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
Q3AKY6
A1E9S0
ATPF_SORBI
ATPase subunit I
Sorghum
MKNVTHSFVFLAHWPFAGSFGLNTDILATNLINLTVVVGVLIFFGKGVLKDLLDNRKQRILSTIRNSEELRRGTLEQLEKARIRLQKVELEADEYRMNGYSEIEREKENLINATSISLEQLEKSKNETLFYEKQRAMNQVRQRVFQQAVQGALGTLNSCLNTELHFRTIRANIGILGAIEWKR
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
A1E9S0
A6KZM1
MUTS_PHOV8
DNA mismatch repair protein MutS
Phocaeicola
MANDVVLTPMMKQFFELKAKHPDAIMLFRCGDFYETYSEDAIVASEILGITLTKRANGQAKSVEMAGFPFHALDTYLPKLVRAGKRVAICDQLEDPKMTKKLVKRGITELVTPGVAINDNVLSYKENNFLAAVHFGKASCGVAFLDISTGEFLTAEGPFDYIDKLLNNFAPKEVLFERGKRGMFEGNFGSKFFTFELDDWVFNESSSREKLLKHFETKNLKGFGVEHLKNGIVASGAILQYLNMTQHYQIGHITSLSRIEEDRYVRLDKFTVRSLELIGSMNEGGTSLLDVIDRTISPMGARLLKRWVVFPLKDEKPVNERLDVVEYFFREPDFKEFIEEKLHLIGDLERIVSKAAVGRISPREVVQLKVALQAIEPIKNACLNADNGSLRRIGEQLNLCLSIREKIAKEVKNDPPLLVNKGGVIADGVNAELDELRQIAFSGKDYLLKVQQRESELTGIPSLKIAYNNVFGYYIEVRNTHKDKVPADWIRKQTLVNAERYITQELKEYEEKILGAEDKILVLETKLYNELVVALAEFIPAIQINASQIARLDCLLAFANVAKENNYIRPVVEDSEVIDIRQGRHPVIEKQLPVGEKYIANDVFLDSETQQIIIITGPNMAGKSALLRQTALITLLAQMGSFVPAESARIGMVDKIFTRVGASDNISVGESTFMVEMNEAANILNNLSSRSLVLFDELGRGTSTYDGISIAWAIVEHIHEHPKAKARTLFATHYHELNEMEKSFKRIKNYNVSVKEIDNKVIFLRKLERGGSEHSFGIHVAKMAGMPKSIVKRANDILHQLETDNRQQGIAKPTAEIASGRSGMQLSFFQLDDPVLSQIRDEILNLDVNNLTPLEALNKLNDIKKIVKGK
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
A6KZM1
R4X244
TCAB1_TULGE
Tuliposide A-converting enzyme b1, amyloplastic
Tulipa
MSVALFCGPPPAVSFGCKDGRGRKGMVRSKDIVRQTVKPPAHACRLIGWNKYPGSVVPTNSSLSPSPTALDDEIELDLSPFLIIYKDGRIERLKGTTVIPACPEVATKDVIIDPATGVSVRLYLPNVVDLPSKKLPVLVYFHGGGFVIENTGSPNYHNYLTLLAAKSGLLIVSVNYRLAPEHPIPASFDDCMAGFNWVVSHSAGPAPEPWLARHGDLTQILISGDSAGGTVTHYVLLRADAGVIEGAALVHPYFLGSKRLENQTEEDFEFHEKLWRLSTPDTEGLDDPLINPLAPGAPSLAGLKCKRAVVFVAELDFLVERGRMYYDALVKSGWGGKAELVHQEGVGHVFHLSDYSGDVSVDMMAKMVAFLRGE
Lactone-forming carboxylesterases, specifically catalyzing intramolecular transesterification, but not hydrolysis. Involved in the biosynthesis of tulipalins, defensive chemicals that show antimicrobial activities against a broad range of strains of bacteria and fungi. Substrates are 6-tuliposide A > 6-tuliposide B.
R4X244
Q557D2
G6PD_DICDI
Glucose-6-phosphate 1-dehydrogenase
Dictyostelium
MTSTPDSRSVLTVIILGASGDLAKKKTYPALFGLYLRDLLPSNTIIYGYARSHIEIGDFKARISKGLKGDEEKKKQFLNLLHYHSGKYDEKASYDEFEKLILAEEKKQQGVDKFNRLFYMAIPPSIFIEVSIGIHGSLISKNGWSRVIVEKPFGRDLASSRELVSELGKLFKEKDLFRIDHYLGKEMVQNLMVLRFANAVFEPLWSKSHISSITITFKEDIGTEGRGGYFDQFGIIRDVMQNHLLQVLSLVAMEPPVSLNADDITNEKVKLLRCIQPIKMSEVVLGQYTSDPEGKIPAYLDDEGVPKDSTTPTYAAAVFHINNPRWRGMPFILKCGKALDERKTEVRIQFKRPDNFLFSDDDISRNELVMRIQPGEAVYLKLLSKKPGLENKIEQTELDLSYRHRFENLDLPDAYERLILDSIKGDHNLFVRDDELDVAWQIFTPLLDQIEKEKIKPEPYSFGSRGPKSADELSKKFGFIRSLGYNWPGNSPQGSKK
Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.
Q557D2
A4WDD6
RECO_ENT38
Recombination protein O
Enterobacter
MEGWQRAFVLHSRPWSETSLMLDVFTEESGRVRLVAKGARSKRSNLKGALQPFTPLLVRFGGRGEVKTLRSAEAVSLALPLSGITLYSGLYVNELISRVLEHETRFSELFFDYLHCIQALAGATDSPEPALRRFELALLGHLGYGVDFLHCAGSGDSVDDTMTYRYREEKGFIASIVIDNTTFTGRHLRALSEREFPDQDTLRAAKRFTRIALKPYLGGKPLKSRELFRQFVPKR
Involved in DNA repair and RecF pathway recombination.
A4WDD6
B0UET5
CAH_METS4
Cyanuric acid amidohydrolase
Methylobacterium
MPRRAEILRLPMAAPDDVSAIAASLRDGRLDPGDVVAVFAKTEGNGCVNDFTRPLAVQALRGLFGPLIGEAALGRIAMVMSGGTEGGLSPHWLVIAAREAAGPGPALAVGQARTPPLAAEDLGRRAQVEMVAAGVRAAMREAGLDAGQVHYVQVKCPLLTSERIGAALARGAAPATRDTLKSMGLSRAAAALGAALALGEVPAAAIGETVAETDPGRHARRCGASAGVELLDHEVVVMGMSPDWTGPLVIDHAVMADAIDLRPVAACLGRLGLLGPDGFVDEAGRARLAALLAKAEASADGAIRGRRHTMLTDSDIAPTRHARGFVAGALAGLVGATDLFVSGGAEFQGPDGGGPVAVIARRSGAAGPA
Responsible for the hydrolysis of cyanuric acid, an intermediate formed during catabolism of s-triazine based compounds in herbicides such as atrazine and polymers such as melamine. Catalyzes the hydrolytic opening of the s-triazine ring of cyanuric acid (2,4,6-trihydroxy-s-triazine) to yield carbon dioxide and carboxybiuret, which spontaneously decarboxylates to biuret.
B0UET5
Q6NTA4
RRAGB_MOUSE
Ras-related GTP-binding protein B
Mus
MEESDSEKKTEKENVGPKVEPPLGEPEGSLGWAMPNAAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPEAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVMSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR
Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.
Q6NTA4
Q980M3
HFLX_SACS2
GTP-binding protein HflX
Saccharolobus
MKTAALFVSKEFEEEAIALVEGANYKVTSIYKLPKSPNVKFYIQYDKLQQIKNDEEISTLIIFEQLKPRHFINIRRELKGKEVLDKILLLLEIFALHAGSKEAKMQIELARLKYELPIIKETYTKSKIGEQQGPLGAGTYGVESTIKFYKRRINKLMKELESIKIFKEKSIESNKRNNIPSIGIVGYTNSGKTSLFNSLTGLTQKVDTKLFTTMSPKRYAIPINNRKIMLVDTVGFIRGIPPQIVDAFFVTLSEAKYSDALILVIDSTFSENLLIETLQSSFEILREIGVSGKPILVTLNKIDKINGDLYKKLDLVEKLSKELYSPIFDVIPISALKRTNLELLRDKIYQLATQLS
GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Specific for GTP.
Q980M3
A8HDJ9
3S11_HOPST
Short neurotoxin 1
Hoplocephalus
MKTLLLTLVVVTIVCLDLGYTMTCCNQQSSQPKTTKTCAESSCYKKTWRDHRGTITERGCGCPSVKPGIQLECCKTNECNN
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
A8HDJ9
P58109
TF2B2_THEKO
Transcription initiation factor IIB 2
Thermococcus
MRGISPKRVCPICGSTEFIYDPRRGEIVCAKCGYVIEENVVDEGPEWRAFEPGQREKRARTGAPMTLMIHDKGLSTDIDWRDKDIHGNQITGMYRNKLRRLRMWQRRMRINDAAERNLAFALSELDRMAAQLRLPRHLKEVAASLYRKAVMKKLIRGRSIEGMVSAALYAACRMEGIPRTLDEIASVSKVSKKEIGRSYRFMARGLGLNLRPTSPIEYVDRFGDALGVSARTKKRAKEILNEAIKRGITSGKGPTGLAAAALYIAALLEGEKKTQREVAEVAHVTEVTVRNRYKELVEKLGINVPI
Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
P58109
Q32FJ0
BTUD_SHIDS
Vitamin B12-transporting ATPase
Shigella
MSIVMQLQDVAESTRLGPLSGEVRAGEILHLVGPNGAGKSTLLARMAGMTSGKGSIQFAGQPLEAWSATKLALHRAYLSQQQTPPFAMPVWHYLTLHQHDKTRTELLNDVAGALALDDKLGRSTNQLSGGEWQRVRLAAVVLQITPQANPAGQLLLLDEPMNSLDVAQQSALDKILSALCQQGLAIVMSSHDLNHTLRHAHRAWLLKGGKMLASGRREEVLTPPNLAQAYGMNFRRLDIEGHRMLISTI
Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
Q32FJ0
Q328K2
ULAC_SHIDS
Ascorbate-specific phosphotransferase enzyme IIA component
Shigella
MKLRDSLAVNKSIRLQAEAETWQDAVKIGVDLLVAADVVEPRYYQAILDGVEQFGPYFVIAPGLTMPHGRPEEGVKKTGFSLVTLKKPLEFNHDDNDPVDILITMAAVDANTHQEVGIMQIVNLFEDEENFDRLRACRTEQEVLDLIDRTNAAA
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport.
Q328K2
Q8PPG8
BETA_XANAC
Betaine aldehyde dehydrogenase
Xanthomonas
MQREYDYIIIGAGSAGNVLAARLTEDPGVTVLLLEAGGPDYRVDFRTQMPAALAFPLQGRRYNWAYETEPEPYMDNRRMECGRGKGLGGSSLINGMCYIRGNALDFDHWAKRPGLEDWSYRDVLPYFRKAETRDIGANDYHGGDGPVSVATPKNDNNVLFHAMVEAGVQAGYPRTGDLNGYQQEGFGPMDRTVTPRGRRASTARGYLDMAKPRDGLHIVTHATTDRILFAGKRAIGVHYLVGNSSEGIDAHARREVLVCAGAIASPQLLQRSGVGAPDLLRALDVQLVHDLPGVGQNLQDHLEVYIQYACTKPVSLYPALQWWNQPAIGAQWLFAGTGTGASNQFEAGGFIRTREEFDWPNIQYHFLPVAINYNGSNAVKEHGFQAHVGSMRTPSRGRVHAKSRDPRQHPSILFNYQSTDQDWQEFRDAIRITREIIAQPALDAYRGREISPSADCKTDAELDAFVRSRAETAYHPSCSCAMGTDAMAVVDGQGRVHGMEGLRVIDASIMPRIITGNLNATTIMIAEKIADRVRGRTPLPRSTADYYIAGDAPVRG
Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
Q8PPG8
P14839
HXB6_CHICK
Homeobox protein Hox-2.2
Gallus
GSSFGPARRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHSLCLTERQIKIWFQNRRMKWKKENKLLSSSQLSAEEEEKTAE
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
P14839
A0R5R0
RECR_MYCS2
Recombination protein RecR
Mycolicibacterium
MFEGPVQDLIDELGKLPGIGPKSAQRIAFHLLSVEPPDIDRLTAVLGRIRDGVTFCSVCGNVSDEERCRICSDPRRDASLVCVVEEPKDVQAVERTREFRGRYHVLGGALDPLSGIGPEQLRIRELLNRIGERVEGVDVAEVIIATDPNTEGEATATYLVRMLRDIPGLTVTRIASGLPMGGDLEFADELTLGRALAGRRAMV
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
A0R5R0
Q8UHK1
HIS1_AGRFC
ATP phosphoribosyltransferase
Agrobacterium tumefaciens complex
MITIALPSKGRMKEDASAVLERAGLKVASVGNDRSYRGRIEGRDDIEVAYLSASEIAREIGAGTVDFGVTGEDLVREGLTNADAQVEFCARLGFGHADVVVAVPEIWLDVDSMADLGDVASEFRARHGRRLAIATKYWRLTQQFFSRQHGIQLYRIVESLGATEGAPAAGQADIIVDITSTGSTLKANHLKILSDGIIVRSEACFVRARKPEHEGDAAIQEIASRIKAAV
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Q8UHK1
B2KAW0
RL21_ELUMP
50S ribosomal protein L21
Elusimicrobium
MYAIIETGGKQYWVKPGQNLQVERLNAEVGANVEVKVLWANDAEGTSADAKAGTDSAKVTAQVVRHLRGKKIIIFKKRPKKGYERTQGHRQDLSEIKITDIKIG
This protein binds to 23S rRNA in the presence of protein L20.
B2KAW0
A3QJS0
RSMG_SHELP
16S rRNA 7-methylguanosine methyltransferase
Shewanella
MLAAQLDSYLADMQMTATPKQKQQLLDFVAMLAKWNKAYNLTSVRDPEQMLIRHIMDSLAASPHLVGERFIDVGTGPGLPGIPLAIMNPDKEFVLLDSLGKRIRFQKQVQFELAIGNISSVESRVEAYQPEEKFDGVLSRAFASIQDMLQWCHHLPKPTGCFYALKGQLSDEEMANMPEGFTLTDVFELKVPRLDEQRHLLRVVKAA
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
A3QJS0
A1T0Z1
ATPA2_PSYIN
F-ATPase subunit alpha 2
Psychromonas
MQLNSTEISDLIKQRIGKFEAVSEARNEGTIVSVSDGIVRINGLAECMQGEMIELPNGGFAMALNLERDSVGAVVMGPFRDLREGQKVKSTGRILEVPVGKGLLGRVVNTLGAPIDGKGPIENDGYSPIEVIAPGVIDRKSVDQPVQTGWKSIDSMVPIGRGQRELIIGDRQVGKTAIAIDAIINQKHTGLFSIYVAIGQKASTIANVVNKLEEHGALENTIVVVASASETAALQYLAPYAGCSMGEYFRDRGEDALIVYDDLSKQAVAYRQISLLLKRPPGREAYPGDVFYLHSRLLERASRVSAAYVEAFTKGAVKGKTGSLTALPIIETQGGDVSAFVPTNVISITDGQIFLTTELFNSGIRPAVDPGISVSRVGGSAQCKVIKKLAGGIRTALAQYRELAAFAQFASDLDETTRKQLDHGKKVTELMKQKQYAPMSVAEQALSLFSAEKGYLTDVDVEKVLDFESSLISYAKTEHAEFYAQLNETGDYSKEIEGQFHAILETFKATQTW
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
A1T0Z1
P69938
GDX_SHIFL
Guanidinium exporter
Shigella
MSWIILVIAGLLEVVWAVGLKYTHGFSRLTPSVITVTAMIVSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGESANPMRLASLALIVLGIIGLKLSTH
Guanidinium ion exporter. Couples guanidinium export to the proton motive force, exchanging one guanidinium ion for two protons.
P69938
C1P608
IBSB_ECOLI
Small toxic protein IbsB
Escherichia
MMKLLIIVVLLVISFPAY
Toxic component of a type I toxin-antitoxin (TA) system.
C1P608
B5RQ59
SYT_BORRA
Threonyl-tRNA synthetase
Borrelia
MGEKLDKDSILYKKRHSIAHVMAEAVLELFPNTKIAIGPPIKDGFYYDFDFEKHISEDDLLLIEHKMREILKTGSPFIREVITREQALVLFKDEPYKIDLIQNFDVTDEITIYKSHKFTDLCRGPHVDNMNKLDPKAFKLTSIAGAYWRGNERNKMLSRIYGTLWNNEKDLKAYLKLQEEIKKRDHRKLGRELNLFSVHDEIGPGLIFFHPHGARIRALIENFWREEHFKNGYDILFTPHIGKSWLWETSGHLDFYKESMFEKIEMDRSDYYVKPMNCPFHIAIYNTDKHSYRDLPFRWAELGTVYRYEKIGAIHGTMRVRGFTQDDAHIICTYEQVNFEVREVLRFAIDMWNKFGFTNLKAYLSTKPEKAVGDDDDWQMAVKVLEKALIDFNIDFDIDEGGGAFYGPKIDLKIIDSLGRAWQMTTIQFDFNLPVRFKMTYTAEDGKEKRPFMIHRALLGSIERFFGILVEHYGGAFPVWLAPLQVVIIPVNSIVEEYALEVLSRFQNEGIRIKFDNYYNMRMNAKIRQYQSKKVPYMFIIGEREVVEGKISIRTRTNEQINGLELKEALEFVKLKISNKEIL
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
B5RQ59
O19895
PSBA_CYACA
Photosystem II Q(B) protein
Cyanidium
MTVTLERRESTSLWERFCSWITSTENRLYIGWFGVLMIPCLLTATTVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIITGAVVPTSNAIGLHLYPIWEAASLDEWLYNGGPYQLVVLHFLLGVAAYMGREWELSYRLGMRPWICVAFSAPVAAATAVFLIYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHMAGVAGVFGGALFSAMHGSLVTSSLIRETTENESPNYGYKLGQEEETYNIVAAHGYFGRLIFQYASFNNSRALHFFLGLWPVVGIWLTSIGISTMAFNLNGLNFNQSIVDSQGRVINTWADIINRANLGIEVMHERNAHNFPLDLADNSLLPVASSSPSINS
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
O19895
Q2J702
RNH2_FRACC
Ribonuclease HII
Frankia
MRHYGVALRRDAGLFGYERALNRHGLGPVAGVDEAGRGACAGPLVIAAVILAPEARQRLARLADSKLLTEQIRESVFEDVMAAAAAWSTVVISAAEIDRVGLHVANITGMRRAVARLSARPGYVLTDGFAVAGFGVESLAVVKGDRVVACVAAASVVAKVTRDRIMRALHTRYAEYDFAQHKGYVTAAHAAALARCGPCDEHRMSYVNVAAHAATTREARSLRLEDRVLVTSRHGVTETV
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q2J702
A1WV99
RS11_HALHL
30S ribosomal protein S11
Halorhodospira
MAKASSRGGGKKKVKRTVSDGVAHINATFNNTLITITDRQGNALSWASAGGSGFKGSRKSTPFAAQVASETAARAAQDYGLKNVEVRVKGPGPGRESAVRALNAVGYRITNISDVSPIPHNGCRPPKKRRV
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
A1WV99
A1JKT0
EX7L_YERE8
Exodeoxyribonuclease VII large subunit
Yersinia
MSQSSASSIFTVSRLNQTVRQLLEMEMGQIWLTAEISNFSQPSSGHWYFTLKDDRAQVRCAMFRNTNRRTTFRPQNGQQVLVRASITLYEPRGDYQLIAESMQPAGDGLLQQQFEQLKQQLAAEGLFDQSHKQPLPSPAKQVGVITSSSGAALHDVLQVLQRRDPSLPVIIYPTAVQGADAPLQIVRAIQLANLRGECDVLIVGRGGGSLEDLWSFNDERVARAIFNSRIPIVSAVGHETDVTIADFVADLRAPTPSAAAELVSRNQIELVRQIQGQQQRMEMAMDYYLAQRHQQLTRLEHRLQQQHPHLRLARQQTLLLKLQRRLEDSAQNQIRRLSRRTERLQQRLVQAQPQGQIHRYNQRVQQQEYRLRQALERQLNGYRQRFGIACSQLEAVSPLATLARGYSVTQTPEGSLLKTTKQVHTGDKLTTRLQDGWVESEITQIKVAKKPRQRKAAN
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
A1JKT0
Q87AA7
COAE_XYLFT
Dephosphocoenzyme A kinase
Xylella
MSVYAVGLTGGVACGKSLLAQLFEALNTTVVDADTIARQVVEPGPVLNCIVARFGSKILRADGCLDRRFLRQRVFADVAERKALEAIVHPVIRARLKQAAAAAAGPYVLVVIPLLAEAGGRIGYPWLQRILVVDAIPEVQHARLMQRDSIDAEQASLMIAAQIGRKERLAIADDIVFNDGDPAHLGGQVCNLDARYRALASVFSDVD
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Q87AA7
A3QIU7
AZOR_SHELP
FMN-dependent NADH-azoreductase
Shewanella
MAKVLVLKSSILGDYSQSAKLIDHLQQHWQGQGAEVTVRDLAAQPLPVLDGEIAMGLRGGDELSPRQQEVLALSDELVAELKAHDTLVIAAPMYNFSIPTQLKNWIDLVARAGVTFTYTETGPKGLVEGKRAVLVTTRGGVHKNGASDHVVPYLKTVLGFIGIDEVETVYGEALNMGPEANEQGISQAKQSIEQLVA
Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
A3QIU7
P04684
NODE_RHILT
Host-specificity of nodulation protein B
Rhizobium
MDRRVVITGIGGLCGLGTNAASIWKEMREGPSAISPIITTDLYDLEGTVGLEIKAIPEHDIPRKQLVSMDRFSLLAVIAATEAMKQAGLSCDEQNAHRFGAAMGLGGPGWDTIEETYRSILLDGVTRARIFTAPKGMPSAAAGHVSIFLGLRGPVFGVTSACAAGNHAIASAVDQIRLGRADVMLAGGSDAPLTWGVLKSWEALRVLAPDTCRPFSADRKGVVLGEGAGMAVLESYEHAAARGATMLAEVAGIGLSGDAYDIVMPSIEGPEAAMRSCLADAELNPDDVDYLNAHGTGTVANDEMETAAIKRVFGDHAFQMSVSSTKSMHAHCLGAASALEMIACVMAIQEGVIPPTANYREPDPQCDLDVTPNVPREQRCGSMSNAFAMGGTNAVLAFRQV
Proposed to synthesize NOD factor fatty acyl chain. Involved in the synthesis of a highly unsaturated fatty acid moiety, which forms part of a lipo-oligosaccharide that is responsible for host specificity.
P04684
P86887
HBB2_LYCRE
Hemoglobin beta-2 chain
Lycodes
VKWTDKERAVILGIFSGLDYEDIGPKALVRCLIVYPWTQRYFGAFGNLSSAAAISGNLKIAAHGVKVLHGLDMALQHMDNIMETYADLSILHSETLHVDPDNFKLLADCLTITIAAKMGHCFTPDTQIAFHKFLAVVVSALGKQYC
Involved in oxygen transport from gills to the various peripheral tissues.
P86887
Q6LUK8
ISPH_PHOPR
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Photobacterium
MKILLANPRGFCAGVDRAISIVERALEMYQPPIYVRHEVVHNRFVVEGLKQRGAIFVEELSEVPDDNIVIFSAHGVSQAVRNEAKERQLTVFDATCPLVTKVHMEVARASRRSVEVVLIGHAGHPEVEGTMGQYASEDGGMYLVEKPEDVEKLQVKDPSNLHYVSQTTLSVDETADVIDQLRKVFPEIQGPRKDDICYATQNRQDAVREMAESVDVMIVVGSKNSSNSNRLRELSEKLGTPGFLTDCPEDVQPVWFEGKTKVGVTAGASAPEDLVNQIISRIQALIGGDVEELSGREENMFFEVPRELQVKNI
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Q6LUK8
Q2J6X0
LEUD_FRACC
Isopropylmalate isomerase
Frankia
MEAFTIHTGRAVPLRRSDVDTDQIIPSEWLKRIERTGFGAGLFAQWRADDGFVLNEPAYAAASILLAGSDFGTGSSREHAVWALQDYGFRAVLSPRFADIFRGNALGNGLLPVQLSAETVEALTSAVEADPTIEITVDLVAREVRGAGLVATFDLDDFTRWRLMEGLDDVGLTLRHEDMITSFEAGRPAWSPTTA
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Q2J6X0
Q1I644
PYRG_PSEE4
UTP--ammonia ligase
Pseudomonas
MTRYIFVTGGVVSSLGKGIASASLAAILEARGLKVTMLKLDPYINVDPGTMSPFQHGEVFVTHDGAETDLDLGHYERFIRTTMTQNNNFTTGRIYEHVLRKERRGDYLGATIQVIPHITDEIKRRIIKGAGDADVALVEIGGTVGDIESQPFLEAIRQLRVEVGSKRAMLMHLTLVPYIATAGETKTKPTQHSVKELRSIGLQPDVLICRSDHPVDASSRRKIALFTNVEERAVISLEDVDTIYKIPGVLHAQGLDDFVVERFGLQCNSADLSEWDKVVDAKLNPEQEVTIAMVGKYMELLDAYKSLIEAMSHAGITNRTKVNLRYIDSEDIENQGTSLLEGADAILVPGGFGLRGVEGKITAVQYARENKVPYLGICLGMQVAVIEFARNVMGWKDANSTEFDRNSGHPVVGLITEWADATGAVETRTEASDLGGTMRLGAQDCQIVAGSKVHDCYGKDVITERHRHRYEVNNNLLPQLMDAGLVVSGRSEDGALVEVVESKDHPWFVACQFHPEFTSTPRDGHPLFSGFVKAALAQKNKA
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Q1I644
Q3AMN1
RL4_SYNSC
50S ribosomal protein L4
unclassified Synechococcus
MASCVVRDWQGKEAGKATLDLKVAKETTAVDLMHRAVLRQQAHARQGTASTLTRSEVRGGGRKPYKQKGTGRARQGSIRTPLKPGGGIIFGPKPRTYNLAMNRKERRLALRTALMARIDDVTVVQDFGASLEAPKTREITDALGRLGVAAGSKVLIVLTNPSDVVRRSVRNLEKVKLISADQLNVFDLLHANALVLGEEALATIQEVYGDD
Forms part of the polypeptide exit tunnel.
Q3AMN1
P29357
HSP7E_SPIOL
Chloroplast envelope membrane 70 kDa heat shock-related protein
Spinacia
MAGKGEGPAIGIDLGTTYSRVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPINTVFDAKRLIGRRFSDASVQADMKHRPFKVVSGPGEKPMIGVNYKGEEKQFAAEEISSMVLTKMKEIAEAYLGSTVKNAVVTVPAYFNDSQRQATKDAGVISGLNVMRIINEPTAAAIAYGLDKKATSVGEKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHSLQEFKRKNKKDIMETPGHIRRLRTACERAKRTLSSTAQTTIEIDSLYEGVDFYSPITRARFEELNIDLFRKCMEPVEKCLRDAKMDKSTVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQAAILSGEGNEKVQDLLLLDVTPLSLGLETAGGVMTVLIPRNTTIPTKKEQVFSTYSDNQPGVLIQVYEGERTRTRDNNLLGKFELSGIPPGPRGVPQINVCFDIDANGILNVSAEDKTTGQKNKIRITNDKGRLSKEEIEKMVQEAEKYKSEDEEHKKKVESKNALENYAYNMRNIVKDEKIGAKLSEADKKKIEEAIDASIQWLDGNQLAEADEFDDKMKELESICNPIIAKMYQGAGGDMGGGMEDEGPTSGGGAGPKIEECRLSCHFF
Sce70 may play a role in the transport of polypeptides across the envelope membrane and into the chloroplast.
P29357
Q57665
ALBA_METJA
DNA/RNA-binding protein Alba
Methanocaldococcus
MDNVVLIGKKPVMNYVVAVLTQLTSNDEVIIKARGKAINKAVDVAEMIRNRFIKDIKIKKIEIGTDKVKNPDGREVNVSTIEIVLAK
Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.
Q57665
Q94K66
ELIP2_ARATH
Early light-induced protein 2, chloroplastic
Arabidopsis
MATASFNMQSVFAAPSGVLTTRNIRNTNQLFFKRIAPVGVRCMAQGDPIKEDPSVPSTSTSATPPQMPQSPPPPVSKPKVSTKFGDLLAFSGPAPERINGRLAMVGFVAAIAMELSKGENVFAQISDGGVGWFLGTTALLTLASMVPLFKGIRAEAKSKGFMTSDAELWNGRFAMLGLVALAFTEYVTGGTLV
Probably involved in the integration of pigments into the mature light-harvesting pigment-protein complexes. Light-harvesting chlorophyll (LHC) a/b-binding protein required to ensure a high rate of chlorophyll accumulation during deetiolation in continuous high light. Involved in seed germination. May fulfill a photoprotective functions. Prevents excess accumulation of free chlorophyll by inhibiting the entire chlorophyll biosynthesis pathway (e.g. 5-aminolevulinate synthesis and Mg-protoporphyrin IX chelatase activity), and hence prevent photooxidative stress.
Q94K66
Q2JUH1
PYRG_SYNJA
UTP--ammonia ligase
unclassified Synechococcus
MAKFVFITGGVVSSIGKGIVAASLGRLLKSRNYTVSILKLDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTDTNMSKLNNVTTGAIYQAVIYKERRGDYQGSTVQVIPHVTQEIKERIRRVARETNPDVVLVEVGGTVGDIESLPFLEAIRQFRKDVGRANVAYVHVTLVPLIKAAGEMKTKPTQHSVKELRSIGIQPDVLVCRCEQPLPRSIKEKISEFCDVPVECVIQAQDAPSIYDVPLVLEQEGLAQRVLQILNLEPQQPDLREWELLVQRLHHPQEQVEIAIVGKYVRLTDAYLSVAEALRHAGLALNAGVTLRWISSEEVEERGPEALLADVDGVVVPGGFGSRGIEGKVATIRYVRERGIPFLGLCLGMQCAVIDWGCNIAGLERANSYEFDPDTPHPVISLLPEQKDVEHLGGTLRLGLYPCRILPDTLAAKLYGESIVYERHRHRYEFNNAYRSLFLESGYVISGVSPDNRLVEIIELPSHPFFIATQFHPEFRSRPNRPHPLFLGLIEAALRSRSRPQALQLQNTG
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Q2JUH1
Q1LJA1
OTC_CUPMC
Ornithine carbamoyltransferase
Cupriavidus
MSPTPIKHYLQFSDLSADEYEYLLDRARILKAKFKNYETWHPLHDRTLAMIFEKNSTRTRLSFEAGIHQLGGHAVFLNTRDSQLGRGEPIEDAAQVISRMVDIIMIRTFGQEIIDRFAKHSRVPVINGLTNEYHPCQVLADVFTYIEQRGTIAGKTVAWIGDANNMAYTWIQAAERLDFTFHFSAPPGYQLDPAMVPDWAASRVKVFDNPLDACQGAHLVTTDVWTSMGFEAENDARKRAFKDWMVTTAMMDRAADDALFMHCLPAHRGEEVEAAVIDGPRSVVWEEAENRLHVQKALMEYLLCGRY
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
Q1LJA1
Q8TFK7
GEP3_CANGA
Found in mitochondrial proteome protein 38
Nakaseomyces/Candida clade
MRFRRYFSSTFKRLIDCNSCGVKLQNKQPGALGYYTKKDDNLVKKITLEDVKYLIFGQDIQRIKEMTVDTENYDIKLEKPLICKRCSEALHNNKYNATEFKDIPFEEVEKQIPLHSNVVHTAPILEFPFHINSQLLKNRTFNTTMVFTKADRVFKNKKQVQKQIPIFLDAFFETYLNSKATRNIVTSTLNRWNLDTLFSFLHGTNYFVGEPNSGKSTLINALLRRLFGVKIRGNDVKNFELDKQAEEELAVSKKFFLEKQLAGVSHIPNLTRTLQAYKIKQKIIYDLPGYSNYNSYRIDEFIDPKWLQRFRKTSIFSEKRVKKKRYDSIVGNENGKCLTLGGIFYLVPPPTTINQIVCYIPGELRQFHNTDRGIEVLGKSGSKEHPLNKYCGIKPGIGKEKYIRHIIPPFQGPIEVVLKDIGYFSLTPTGKYEYKGLYELWVLDGIDVCIRKPLERVAEDSYDKSQEGKYYIKEPVVSHTYVVAHNDPNPLQTVKESYEKVKERTDEILNKYNLEKFGNNMWHFKW
May be involved in the mitochondrial lipid metabolism.
Q8TFK7
Q55GA0
Y7754_DICDI
TNF receptor-associated factor family protein DDB_G0267754
Dictyostelium
MTSLISITLDELLINEDINDDYTCCVCECLLIEALQCRNGHVACKNCFIKIVKSKKECMTCRCEIKSIESLSKNRYLEKEIRKLNINCPNSFLKRELNLNNNNKNGNGNEGSSANEIEQPQQPQQQQPQELIKDINNGCKEILTIDQLDSHLKQCEYRFLKCTNLYANDLCSELDICGYDYRYNQSEKHRDECPYGIIGCTLCGKDCSRVDIESHTENHCPKLLVKCPTCNQDQLIARCDLDDHLSVDCAMIEIDCILKESGCKERVKRNQLANHLSSDNHLLFINNQFNQQNDIINQLKLELSHCNDLNEILTAKLDRYNNDNTMFRGKWVISNWTDKLNQYPPKKYLSLDFNLSQNKPFSIRVYPNGSSVMWHNCTISLVKLYQTESTIKFSFEIENEDPLKNDLQTKTDIFKGLNDSWSLQFFKVCDQANNNGFIINDTLTINFSIKIKKCFENIFITE
Probable adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases.
Q55GA0
Q9PK27
AROK_CHLMU
Shikimate kinase
Chlamydia
MPTFDTTKQIFLCGLPSVGKTSFGRLLAQFLSLPFFDTDHLLSARFHGDSPKAIYQRFGEEGFCQEELLTLINLPVIPSVVALGGKTLLDKQIYEHITQRENILLVLLDLPFATLYQRLQKKPLPESLKNTPSLENALFQRLEKLRLLTPHIFSLQAATSLHEIGEVCQSFCLQFLTAQEIPYA
Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.
Q9PK27
P77400
YBAT_ECOLI
Inner membrane transport protein YbaT
Escherichia
MMNTEGNNGNKPLGLWNVVSIGIGAMVGAGIFALLGQAALLMEASTWVAFAFGGIVAMFSGYAYARLGASYPSNGGIIDFFRRGLGNGVFSLALSLLYLLTLAVSIAMVARAFGAYAVQFLHEGSQEEHLILLYALGIIAVMTLFNSLSNHAVGRLEVILVGIKMMILLLLIIAGVWSLQPAHISVSAPPSSGAFFSCIGITFLAYAGFGMMANAADKVKDPQVIMPRAFLVAIGVTTLLYISLALVLLSDVSALELEKYADTAVAQAASPLLGHVGYVIVVIGALLATASAINANLFAVFNIMDNMGSERELPKLMNKSLWRQSTWGNIIVVVLIMLMTAALNLGSLASVASATFLICYLAVFVVAIRLRHDIHASLPILIVGTLVMLLVIVGFIYSLWSQGSRALIWIIGSLLLSLIVAMVMKRNKTV
Probable amino-acid or metabolite transport protein.
P77400
C0Q9Y7
EFTU_DESAH
Elongation factor Tu
Desulforapulum
MAKEKFERTKPHVNIGTIGHIDHGKTTLTAAITKHAALRGFGKFVAFDEIDKAPEERERGITISTAHVEYETAKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSADDGPMPQTREHILLARQVGVPSIVVFLNKCDMVDDEELIELVEMELQELLTKYEFPGDDTPIVRGSALKALEADTSDDPAAEPILKLLDVLDEYVKEPVRDTDKDFLMPIEDVFSISGRGTVVTGRIDRGIIKTGEEVELVGIRDTTKTICTGVEMFRKLLDEGRAGDNVGLLLRGTKRDAVERGQVVAKPGTITPHTKFKAEIYCLSKEEGGRHTPFFSGYRPQFFFRTTDVTGVLSLPEGVEMIMPGDNAAITAELIAPIAMEKELRFAIREGGRTVGAGVIGEIIE
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
C0Q9Y7
Q5KUV3
KDPA_GEOKA
Potassium-translocating ATPase A chain
Geobacillus thermoleovorans group
MWHVFSQYTLIFLLLIVIAVPLGKYLYVAFFEKGKIDRFFSPIEAVIYRLSGIRSLEEMTWKSYCTALLIVNAALLGISYGLLRIQHYLPLNGAKVENMEPTLTFNTVVSFMTNTNLQHYSGESGLSILSQMLFVTMMMFTSAATGLTVATALIRALSKKGKTIGNFYQDFVRANVRVLLPLSVIVTILLVAFGVPQTFLARMAVSTLEGGTQTLALGPVASLESIKHLGTNGGGFFGANSSHPFENPHPFTNVIEMLSMWCIPAALPFTYGHAVKNRKQGWVLFATMFVLFVMMLGVVYNAEQSGNPLVGKSGFAADQGNMEGKEVRFGIPLSSLFTAITTAATTGSVNNMHDSLTPIGGLVPLALMMLNNVFGGDGVGFVNIMMYAMIAVFLSGLMVGRTPEFLGRKIEPKEMKLIVIALLLHPLIILAPSAIALMTHMGTEAISNPGFHGISQVVYEYTSSAANNGSGFEGLKDNTAFWNISTGVVMLLGRYVSIIAMLAVAGSLVGKQPVPETIGTFRTDTATFGVILFGTVFIIGALTFFPVLILGPVAEYLTIR
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.
Q5KUV3
Q37595
COX2_PERFA
Cytochrome c oxidase polypeptide II
Perognathus
MAYPLQLGLQDATSPIMEELTSFHDHTLMIVFLISTLVLYIISLMLTTKLTHTSTMDAQEIETIWTILPAIILIMIALPSLRVLYMMDEINNPALTVKTMGHQWYWSYEYTDYEDLSFDSYMVNTTDLKPGDLRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQATVSSSRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFEAWSASM
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Q37595
B6EI79
MGSA_ALISL
Methylglyoxal synthase
Aliivibrio
MKKTTRIVPAHKHIALVAHDNYKAELLRWVKENKEALQGHFLYATGTTGHLLSKETGLAIKSLLSGPMGGDQQLGALISEGKIDMMIFFWDPLNAVPHDPDVKALLRIATVWNVPVAMNRSSAKFMISSPRMTQEIEIEIPDYPAYLAERI
Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.
B6EI79
Q3BWK4
Y1128_XANC5
Nucleoid-associated protein XCV1128
Xanthomonas
MRGNIAQLMQQAQKMQENLQRAQEELAKLEVTGSAGGGMVSVTLTGAKECRKVRIDPSILSDQEMAEDLIAAAFNDASNKIDAESKDRMGSATAGMQLPPGMKLPF
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
Q3BWK4
Q6NY52
THOC5_DANRE
THO complex subunit 5 homolog
Danio
MSSDAVKKRKPKVIRSEAGTPETKRGRAESEQDVRVYNEEVELEGRDPQQDYTLYKETCAALAKLMSEIQELKTSGAKDGSAEIELRRKQSSIHFITLKKLNRLAHMRLKKGRDQTHEAKQRVDVLHLQLQNLLYEVMHLQKEIGKCLEFKSQHEEIELVSEDEFFQDAPAEISRPQVTREDHHQLTLARLDWELDQRKRLAEQYKTSLSSKEKIQKAIEQKREYLSSLQPGLHNIMQASLPVQEYLSMPFEHMQKQAEVARHLPPPLYVLFVQAGAYGQACDKNLTVSIRGDVDEAKALSRPPEDSQDDESDSDAEEEQQNTKRRRPTVGVQLDDKRKEMLRRHPLSLGIDLKCKDGSVLHLYFYYLMNLNILTVKTKVSTSVDLSGAISAGELLNSESLLNCLYASDHGNETPNPANRYQFDKVGITTFADYVSDLGHPYVWVQKLSGLQFSSDAAQSELSGSALSASHMEKSMKLLRGRLQSRLALHKQFSSLEHSIVPVSSECQHLFPAKVVSGLTRWTMMSHQEFTELSFVQHVLKAGLVSETDLFFKAVVERGTARLLAAVVVNPRYPEVTPLFSLSLLWKGERSGRTDDNLRAMESEVNVFRAELQGPRPGLQLLTNQIQRLCMCLDVYLETESQVSDGSEGPKEFPREKMCLRTARGPSRLKPFKYNHPQGFFSHR
May be involved in cell differentiation.
Q6NY52
Q0SNY6
MNMG_BORAP
Glucose-inhibited division protein A
Borreliella
MDFDAIVIGGGHAGIEAALAISRLNFKTLMITQNLDTIGKLSCNPAIGGLAKGNMVREIDALGGEMGRIIDFSMIQFRVLNKSRGPAVQAPRAQADKLMYQTKAKETLERQDNLDLFQDTVVDFLLNSMRNEIEGVVTERGNKFRSSVVVLTTGTFLRGKIFIGEYRANMGRLAEFSAYGLDKTLLGLGFEMGRLKTGTPARIHRKSVDFSKTEVQFGDSDIIPFSFSNGKLDKSQLSCYVTYTNKRTHEIISENMHLSPLYSGEIVGNGPRYCPSIEDKIVKFKDKDRHQIFIEPEGFNTEEMYLNGLSSSLPENVQQKLINSIEGLEHAVITRPGYAVEYDYINPIELYPSLESKRVKGLFIAGQTNGSSGYEEAAAQGLMAGINAALRLQNKKPMILTRTSSYIGVLIDDLVTKGTKEPYRMFTSRAEHRLNLRHDTSDKRLIKIGYDLGLVDEERYSKYLFKKRRVEEIKELLKQRRLSLKDIADEQLKKHVNKDFYHILKDPSISLDNLIKIDPSLSDSKVILEQVELDIKYEGYINRQKDLIKKLHNLELVKLPFDFNYGIIEGLSREAREKFSKVQPATLAQASRIPGIRNTDITVLFIYFSNPKNKVVLNFSV
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q0SNY6
Q23519
MS152_CAEEL
Major sperm protein 152
Caenorhabditis
MTQSVPPGDIQTQPGTKIVFNAPYDDKHTYHIKVINSSARRIGYGIKTTNMKRLGVDPPCGVLDPKEAVLLAVSCDAFAFGQEDTNNDRITVEWTNTPDGAAKQFRREWFQGDGMVRRKNLPIEYNP
Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.
Q23519
A7ZDX8
RIMM_CAMC1
Ribosome maturation factor RimM
Campylobacter
MNSDIVEVATIGRCVGLKGYLKLHNKSDFPEQFKKGATFFDKNDDQLIIKDYNRQKELVLFEKFDDLDLAKTLVNKTIYTTKELTRKNCKLKKDEFFQFDIIGLKVVENGEILGIVEDIQDNFANSLLYIKTDEVLIAAGKPKNFYIPYLERFIESVNLDSGEILVKGARDILENS
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
A7ZDX8
B3EPG5
DEF_CHLPB
Polypeptide deformylase
Chlorobium
MILPINTYSDEVLRRKAKPLKESDAQLEELISNMLESMRNAEGIGLAAPQVGVSLRLIVVDLSLAEGYEAASPMVVINPHILSVKSFNSMEEGCLSIPDVRGDVVRPSAIQLKYRDRNFEECIGEFDRLAARVIQHEIDHLDGTLFVDRMQRRDRRKIQKELDALSRGEINTNYPVAFHEDSVVK
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
B3EPG5
Q96NT5
PCFT_HUMAN
Solute carrier family 46 member 1
Homo
MEGSASPPEKPRARPAAAVLCRGPVEPLVFLANFALVLQGPLTTQYLWHRFSADLGYNGTRQRGGCSNRSADPTMQEVETLTSHWTLYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILCALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLALALLIAMTLYAAFCFGETLKEPKSTRLFTFRHHRSIVQLYVAPAPEKSRKHLALYSLAIFVVITVHFGAQDILTLYELSTPLCWDSKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGLAFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAMLTASGIFNSLYPATLNFMKGFPFLLGAGLLLIPAVLIGMLEKADPHLEFQQFPQSP
Inactive isoform which is not able to mediate proton-coupled folate transport.
Q96NT5
B3DXL0
AROC_METI4
5-enolpyruvylshikimate-3-phosphate phospholyase
Methylacidiphilum
MPNTFGHLFRITTWGESHGKGVGVVIDGCPPRIPLSEEDIQKELDRRRPGQSKITTQRKERDIAAILSGTFNGMTLGTPIMIWVKNEDARPEAYAEMEKIYRPSHADFTYQAKYGIRNWQGGGRSSARETIGRVAGGAVGGKVLQFLYPEIEVIAWVSEVHGLKSLCDPNTVTREDVESNILRWPNAENLGEALKEIERAQKEGDTVGGIVECIVRGMPVGLGEPVFDKLEADLAKAMLSLPASKGFEIGSGFRGALMRGSEHNDPFYMEGNKVRTKTNWSGGVQGGISNGENLYFRVAFKPVATIAQEQQTVSVDGEEVILRARGRHDPCVLPRAVPIVEAMTKLVLVDHALRQKAIELTPRSFS
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
B3DXL0
B8ZTB7
DNAK_MYCLB
Heat shock protein 70
Mycobacterium
MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSTVAFARNGEVLVGQPAKNQAVTNVDRTIRSVKRHMGSDWSIEIDGKKYTAQEISARVLMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKEAGQIAGLNVLRIVNEPTAAALAYGLDKGEREQTILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDDRIVNWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSVNLPYITVDSDKNPLFLDEQLIRAEFQRITQDLLDRTRQPFQSVVKDAGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTKLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIASHNKLLGSFELTGIPPAPRGVPQIEVTFDIDANGIVHVTAKDKGTGKENTIKIQEGSGLSKEEIDRMVKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQRETENGSRVPEDTLNKVEAAVAEAKTALGGTDISAIKSAMEKLGQDSQALGQAIYEATQAASKVGGEASAPGGSNSTDDVVDAEVVDDERESK
Acts as a chaperone.
B8ZTB7
P0CH43
DKTX_CYRSC
Double-knot toxin
Cyriopagopus
DCAKEGEVCSWGKKCCDLDNFYCPMEFIPHCKKYKPYVPVTTNCAKEGEVCGWGSKCCHGLDCPLAFIPYCEKYRGRND
Selectively activates the heat-activated TRPV1 channel. It binds to TRPV1 in an open state-dependent manner, trapping it there to produce irreversible currents . It binds to the outer edge of the external pore of TRPV1 in a counterclockwise configuration, using a limited protein-protein interface and inserting hydrophobic residues into the bilayer . It also partitions naturally into membranes, with the two lobes exhibiting opposing energetics for membrane partitioning (K1) and channel activation (K2) . In addition, the toxin disrupts a cluster of hydrophobic residues behind the selectivity filter that are critical for channel activation .
P0CH43
Q9CQH8
RPP14_MOUSE
Ribonuclease P protein subunit p14
Mus
MPATAYERVVYKSPSEYHYMKVCLEFQEHGVGLNVAQFKQLLVSALRDLFGEVGAALPVDVLTYDEKTLSAILRICSSGLVKLWSSLTLFGAYKSKKCAFRVIQVSPFLLALSGNSREQVLD
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.
Q9CQH8
A8F754
CLPP_PSELT
Endopeptidase Clp
Pseudothermotoga
MKITDQLIPTVIESTGRYERAYDIYSRLLKDRIVFLGYAIDDHVANLVVAQLLFLEAEDPDKDIQLYINSPGGSVTAGLAIYDTMQYIKSDVVTICVGQAASMAAVLLASGTKGKRFALPNARIMLHQPLGGAEGPVKDVEIITKELLRIKNLINTILSEKTGQPLDRIEKDTDRDFFMSAYEALDYGLVDKVIESKRR
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
A8F754
Q8UD97
PTH_AGRFC
Peptidyl-tRNA hydrolase
Agrobacterium tumefaciens complex
MKIIAGLGNPGAQYAGNRHNIGFMAVDALQRLPSFAPWSKKFKAEISEGEIGGEKVLLMKPLTYMNLSGESVGEAMRFFKLTPADIIAIHDELDLLAGRTRIKIGGGHGGHNGLKSLDAHCGKEYRRLRLGIGHPGDKERVHGHVLGDFAKSDRVWLDPLLDAIADNAAMLVKGDDSQLMNKLALATGSKPEAEKPVKVAKPAAQSHIHQARNSAQPKKLPETGPMAEMLKRMFGKKD
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.
Q8UD97
Q3AE32
THIM_CARHZ
4-methyl-5-beta-hydroxyethylthiazole kinase
Carboxydothermus
MLNTLWEIREKVRDLSPLVVNLTNNVVTNFTANVLLAAGASPIMSEGVEEADDLVKIANAVVINIGTLHSRQVEYFKKAVYLANKYQKPLLLDPVGLGATTYRNETTFELLNSGNFTLIRGNYGEISFLAGNSAQVKGVDSQTSDFAAENLTEVAKRYKTVVVATGPVDYVIAEGELYLNRTGDIMLQKVTGTGCALTSLIGAFVGVIDEPALAALAALAFYGAASEKARKISAGPGSFLVNFIDSLYNLTKEEFLELTTEKVQGLR
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
Q3AE32
Q8DXR8
RSMA_STRA5
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Streptococcus
MRIADKTVTRAILERHGFTFKKSFGQNFLTDTNILQKIVDTAEIDKGVNVIEIGPGIGALTEFLAENAAEVMAFEIDDRLIPILADTLARFDNVQVVNQDILKADLQTQIQAFKNPDLPIKVVANLPYYITTPILMHLIESKIPFAEFVVMIQKEVADRISAMPNTKAYGSLSIAVQYYMTAKVSFIVPRTVFVPAPNVDSAILKMVRRDQPVVSVQDEDFFFRVSKVAFVHRRKTLWNNLTSHFGKSEDTKAKLEKALEIAKIKPSIRGEALSIPDFASLADALKEVGI
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q8DXR8
Q12VU4
MTRE_METBU
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E
Methanococcoides
MEPLMGMGVLALMGAAATIAGTTEDLESDVGSQSNPNSQVQLAPQMMYPHRIYNKAISGEPPSNALICAIGGTVASVLMTANLSVIFAIAIGALVASAVHGTYCITAYMGRTASQKRFRQPIYLDILRSHTPVMMGYAFITTFCILVVSYIMVAVLAHPFPLTLLAFIWGITVGAIGSSTGDVHYGAEREFQNVEFGSGLNAANSGNIVRKAESGLRNGIDNSWFCAKFGGPVTGLAFGMTVFLSGWVTAVFNPAISLTMGWLSVAAGVILVLLLIIWNRKIEVAARKAFGPYKEEEEVAA
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
Q12VU4
Q32902
PSBZ_PEA
Photosystem II reaction center protein Z
Pisum
MTIAFQLAVFALIVTSSILLISVPVVFASPDGWSSNKNVVFSGTSLWIGLVFLVGILNSLIS
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
Q32902
B0R7H7
RFCS_HALS3
Clamp loader small subunit
Halobacterium
MTDAAGGRQEIWVEKYRPERLEDVVGHPDITERLQSYVDRDDLPHLLFAGPAGTGKTASSVSIAKELYGDDWQDNFLELNASDERGIDVVRDRIKDFARSSFGGHNYRVIFLDEADALTDDAQSALRRTMEQFSNNTRFILSCNYSSKIIDPIQSRCAVFRFAQLGDDAVAAHLREIAETEGLEHTDDGIDALVYAADGDMRRAINALQAASATGDSVNEETVYAITATARPEEIETMVTEALGGDFAAARATLDDLLTNRGLAGGDIIDQVHRSVWEFDVEEAAAVRLLDRLGEADYRIAEGANERVQLEALLASVALNAE
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
B0R7H7
Q9HBY8
SGK2_HUMAN
Serum/glucocorticoid-regulated kinase 2
Homo
MNSSPAGTPSPQPSRANGNINLGPSANPNAQPTDFDFLKVIGKGNYGKVLLAKRKSDGAFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHPFLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEDTTSTFCGTPEYLAPEVLRKEPYDRAVDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQRQRLGSKADFLEIKNHVFFSPINWDDLYHKRLTPPFNPNVTGPADLKHFDPEFTQEAVSKSIGCTPDTVASSSGASSAFLGFSYAPEDDDILDC
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase.
Q9HBY8
A5U087
RL3_MYCTA
50S ribosomal protein L3
Mycobacterium tuberculosis complex
MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
A5U087
P47474
RL21_MYCGE
50S ribosomal protein L21
Mycoplasma
MHAIVVCGAKQYLVHENESIFVEKLAGKVGQEIQLDKVLMLDEKIGKPYLEKAKVVCVIEKHGLKSKIKLIKHISQKHHLKRYGHRQPYTKLKVVRFIHD
This protein binds to 23S rRNA in the presence of protein L20.
P47474