accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
B9KR99
LPXK_CERSK
Lipid A 4'-kinase
Cereibacter
MRPPAFWFTPPDRPALAARLLAPLGQAYAAATARRLRAPGHRAGVPVICIGNLNAGGTGKTPTAIALMQRLAARGIEAHVVSRGYGGRLEGPVEVDARRHRAADVGDEPLLLAAFGRAWVARDRAAGVRAAEAAGAQAILLDDGFQNPSVVKDLSLIVVDAAVGFGNGRCLPAGPLREPVEAGLARADLLLSIGGPEAQRRFATDWPALPVPRLTGRLATLQMGMYWQGARVLAFAGIGRPEKFFASLRAEGAELLRAEALDDHQPLGEALMKRLEIEAMALGAQLVTTEKDAVRLPPSFRQKVLTLPVRLEFDDGSALDAALDRLNLTARS
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
B9KR99
Q971I8
SECE_SULTO
Protein transport protein Sec61 gamma subunit homolog
Sulfurisphaera
MSLSQRLKNLREDWKRIISVAKKPEKDTLNQSIKLTLLVMAIVGIIAYIIQLTVALLLH
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
Q971I8
Q8FT51
DEF1_COREF
Polypeptide deformylase 1
Corynebacterium
MTVRDVRIFGDPVLTSRADEVVDFDESLATLIDDMFDTMEDAGGVGLAANQVGVLRRVFVFDCSHVDGGLRGHVVNPVWEPIGEETQTGKEGCLSIPDVSAETTRYETVKLSGQDRDGNPIGLVASGLLSRCIQHETDHLDGVLFLKRLDPAERKAAMGVIRASDWFNK
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Q8FT51
P0A2F7
SSB1_SALTI
Single-stranded DNA-binding protein 1
Salmonella
MASRGVNKVILVGNLGQDPEVRYMPSGGAVANLTLATSESWRDKQTGEMKEQTEWHRVVMFGKLAEVAGEYLRKGSQVYIEGQLRTRKWTDQSGQERYTTEINVPQIGGVMQMLGGRQGGGAPAGGQQQGGWGQPQQPQQPQGGNQFSGGAQSRPQQSAPAPSNEPPMDFDDDIPF
Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
P0A2F7
P13077
FLAB2_HALSA
Flagellin B2
Halobacterium
MFEFITDEDERGQVGIGTLIVFIAMVLVAAIAAGVLINTAGYLQSKGSATGEEASAQVSNRINIVSAYGNVDTSGSTEVVNYANLTVRQAAGADNINLSKSTIQWIGPDTATTLTYDGTTADAENFTTNSIKGDNADVLVDQSDRIEIVMDAAEITTNGLKAGEEVQLTVTTQYGSKTTYWANVPESLKDKNAVTL
Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.
P13077
A8G734
RL31_PROM2
50S ribosomal protein L31
Prochlorococcus
MPKSEIHPKWYPDAKVICNGEVVMTTGSTQPELHVDVWSGNHPFFTGTQKILDTEGRVDRFMKKYGMGSANSATSKEQKADKDSQK
Binds the 23S rRNA.
A8G734
Q8HS25
PSBT_PEA
Photosystem II reaction center protein T
Pisum
MEALVYTFLLVSTLGIIFFAIFFREPPKVPTKNTK
Seems to play a role in the dimerization of PSII.
Q8HS25
B3EP42
RL15_CHLPB
50S ribosomal protein L15
Chlorobium
MDLSSLRPAKGAVKNKKRIGRGPGSGNGTTAGKGNKGQQSRSGYTRPVSEGGQMPIYRRLPKFGFTKPNRKNVIPVNLSQIALWMENGKATSEITVENLKSLCSARRADYFKILGNGELKSPVTITAHFVSKSAQEKILQAGGTITLAERTLLEAERIKDTPVEEGLMKPKARLRKKKKIKS
Binds to the 23S rRNA.
B3EP42
Q2YUP1
DNAA_STAAB
Chromosomal replication initiator protein DnaA
Staphylococcus
MSEKEIWEKVLKIAQEKLSAVSYSTFLKDTELYTIKDGEAIVLSSIPFNANWLNQQYAEIIQAILFDVVGYEVKPHFITTEELANYSNNETATPKETTKPSTETTEDNHVLGREQFNAHNTFDTFVIGPGNRFPHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAIGHHVLDNNPDAKVIYTSSEKFTNEFIKSIRDNEGEAFRERYRNIDVLLIDDIQFIQNKVQTQEEFFYTFNELHQNNKQIVISSDRPPKEIAQLEDRLRSRFEWGLIVDITPPDYETRMAILQKKIEEEKLDIPPEALNYIANQIQSNIRELEGALTRLLAYSQLLGKPITTELTAEALKDIIQAPKSKKITIQDIQKIVGQYYNVRIEDFSAKKRTKSIAYPRQIAMYLSRELTDFSLPKIGEEFGGRDHTTVIHAHEKISKDLKEDPIFKQEVENLEKEIRNV
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
Q2YUP1
Q8M9X3
CEMA_CHAGL
Chloroplast envelope membrane protein
Chaetosphaeridium
MKLIIYQIIKFLLITYYDCLHKAYNESKKIQKIQNEYISYTQLLTSAQHSSQTVILYIDSEINKCLFFINLNLFKYKIIKLVINFIGEDKISNFLSNHVDIKNEYVNLSIEKIFSSNSDFRKSQSESNSKNLVLKKNLDTNKNFHFDFLKYKIKYERQLAWVEAVLEDLKIWKDFYLYNFDFFNKKINNTRRFFFFNKPSSYTLSLSYESIGLIPRSITRTLSKFQTELLGNSYSYIIQEFRLAKYHTWVSLQYVASLIFLPWLITKLCQNLFLQSWIENWWNTSQSQIFINLSQQTKALQRLQQLEELLWLDMAMSERIEGQPQDLGALIHQRTIQLAEYYNQDSINIILHLFTDFIAIFTLIVLLILGKKRLAILNSWVQEVFYSLTDTMKAFLILLFTDLCIGFHSPHGWEIAIDGLLEHLGFAHNKYIVSCLVSTFPVILDTVLKYWIFRHLNRISPSIVVTYHTMNE
May be involved in proton extrusion. Indirectly promotes efficient inorganic carbon uptake into chloroplasts.
Q8M9X3
B0S9S9
QUEC_LEPBA
Queuosine biosynthesis protein QueC
Leptospira
MVSILDSSFKSKTEKKGAIVLLSGGLDSTTCLYLAAKDFGYPKNKKLPLLALSFDYSQKHKIELTKSKKIAKTLGIKHVIQKLDPGFFLGSSLTESKIKVRKNAKSLFSGDETEIPNTYVPGRNILFLSFALSLAEGHGYDSIYIGVNALDYSGYPDCRPEFIDSFQKMANLGTKKGVSGTGDSIQIKTPLLHLGKKEIIELGMSVGAPLGLTHSCYDPVSGKPCGKCDSCILRAKGFLEVGLKDPAL
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
B0S9S9
A6L0W6
RIMM_PHOV8
Ribosome maturation factor RimM
Phocaeicola
MIKKDEVFKIGIFNKPHGVKGEISFTFTDDIFDRVECEYLVCLLDGIFVPFFIEEYRFRSDTTALVKLEGVDTSEKARMFTNVEVYFPKKYVGEEEDSDDIPTWNYFIGFKVEDVNHGELGEIVAVDDSTMNVLFAIEKGGEELLLPAHEEFITKLDKKKRLLTVEVPDGLI
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
A6L0W6
P86015
PER3_VITVI
Peroxidase 3
Vitis
QTFVTIPGTLRDHPDNLSLAGDGFDTVIKVSCADILTMATR
Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
P86015
Q62401
CCL12_MOUSE
Small-inducible cytokine A12
Mus
MKISTLLCLLLIATTISPQVLAGPDAVSTPVTCCYNVVKQKIHVRKLKSYRRITSSQCPREAVIFRTILDKEICADPKEKWVKNSINHLDKTSQTFILEPSCLG
Chemotactic factor that attracts eosinophils, monocytes, and lymphocytes but not neutrophils. Potent monocyte active chemokine that signals through CCR2. Involved in allergic inflammation and the host response to pathogens and may play a pivotal role during early stages of allergic lung inflammation.
Q62401
B0R2L5
MOAA_HALS3
Molybdenum cofactor biosynthesis protein A
Halobacterium
MLEDDFGRDVSGVRVSLTDRCNFDCVYCHNEGLGDTRGPIDPRENELSTDRVVRFLSVAHEFGVDAVKLTGGEPMLRSDLEAIIRRTPDDMAVSMTTNGTFLPGRAADLVDAGLERVNISQDAMDNDAFAELTQSGAYDAVLEGVEAALDAGLAPVKLNMVVFEPTAGYVPEMVDHVAARDGLRLQLIEYMPELAGHPEWAIDIDRVHDWLADRADRIETREMHDRRRYWVSSRDAGSTADDAAQSVTPDGGAHPDQGMVEIVDPVGNPQFCANCHRVRLTHDGYLKGCLNRNDDLRGIGETTQSMRAAFRETVANRVPYYGEYMTRTDDGGWEINDDYLDVEGDRDPYEYAADDSA
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
B0R2L5
F1SY52
CY045_POSPM
Cytochrome P450 monooxygenase 45
Postia
MHSVLAQAASGALSFELRLGQSSVLTICILALLTFVLREIVLYFTRHSMPPGPFRWPLIGNALQLPQDHPWVKYTEWAKMYGPLMQLDVLGQHMLVITSAQTARDLMEKRSSIYSDRPHLVMAGDLAGFGDTLILQNYGEEFRYQRKLVSHSFSPSVIHRYYDLQEAAARRLVLAIIEDPDSLENSTRLHIASIILRMTYGYTVKGVDDPLFTTGIAVINGFSEATRPGAWPVDFVPILQYVPHWVPGFVFTRKAREWRGVLERAMWAPYHWCKENYARDAAHGLCLCGSILAAEGSQLSSDQEWLFVNAAVTVMGGGLDTNISTILSFVLAMLRFPEVQKKAQAEIDAVIGPNRLPLISDRHSLPYVRSVVTEVYRWIPAVPLGIPHALRQDDHYDGLFLSKGSVVVPNVWGMLHDPSIYPAPHEFKPERYGGLDAEMTKVTDIAFGFGRRACPGFYFAEGTIFAIVATVLAICDVVPTVDEHGQEVIPEVSLTSGAIVSPENVKCAFRPRSGRVKDILVEAVETEQE
Cytochrome P450 monooxygenase that is able to use trans-stilbene as a substrate for oxidation.
F1SY52
Q02710
ECM23_YEAST
SRD1 homolog 2
Saccharomyces
MLYNKEQGTSGASSSGRRTKFHFDRFVQMVLFIAANPNYCCSVASIPKSGVTPDLKRADILEQKIKSLNSALSPKLKEESRLGGPLHNPSILPAPSFSSLPISSNGKKSLAGYRPKSRKKQTILPNGQPKECATCGDTWTSQWRSGPNGNVELCSRCGIAYRKKMEKKIRSQQSSDDGTKNFIFKNK
Involved in morphogenesis. May be involved in cell wall organization and biogenesis.
Q02710
Q6A8N5
LGT_CUTAK
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Cutibacterium
MRHRRRPGGRSTAGGTPVSQLSIPSPSIEAFHLGPLTIHIYALCILAGIVVAYISGGRRYQARGGKQEQFEELCALAVIAGIIGGRLYHVITDHQLYFGPGRTWYHCFFIWQGGLGIWGAISLGGLAIWLYCRRKGIRFASVADSLAPGILAAQAIGRLGNWFNQELFGRPTSLPWGLEIDLSHRPAGYLQYATFHPTFLYELVWSLVGAVFLLWVDRRWTLDHGRLFTLYVAIYTFGRFWVERLRIDPAHHVGQWRLNDVTALVVFTGAVVILIVLQRRYGKGDEHSSCPAHKTR
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Q6A8N5
Q8AV97
SLAA_PROFL
Snaclec flavocetin-A subunit alpha
Protobothrops
MERLIFVSFGLLVVILSLSGTGADFDCIPGWSAYDRYCYQAFSKPKNWEDAESFCEEGVKTSHLVSIESSGEGDFVAQLVAEKIKTSFQYVWIGLRIQNKEQQCRSEWSDASSVNYENLVKQFSKKCYALKKGTELRTWFNVYCGTENPFVCKYTPEC
Strong platelet aggregation inhibitor. Binds specifically to platelet glycoprotein Ibalpha (GP1BA) with high affinity and inhibits vWF-dependent platelet aggregation . Has also been observed to induce small agglutinates in washed platelets by binding to GPIb .
Q8AV97
Q54E86
MND1_DICDI
Meiotic nuclear division protein 1 homolog
Dictyostelium
MATRRKGMSPEEKKEKLKEFFHSNSTIYSSKDVESEASKYTGMTQVQCKETLQMLIDDGVVNTDKMGSSNFYWSFPSFEFDSKKDKIIEQTKLLSETKERIQSETKKIEQLKSERVESETRTKNLEKLQTLKDDNKSFKEELLLYADSSLIDDKKRDIKIAIAAVNRYTDNISSLRQFCDSKYNIRPSDFDTSFGIKPDMDYLEEYNFNDTPQPVNKKKRK
Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination.
Q54E86
C0Q3L1
RHAD_SALPC
Rhamnulose-1-phosphate aldolase
Salmonella
MQNITDSWFVQGMIKATSDAWLKGWDERNGGNLTLRLDETDIAPFAANFHEKPRYIALSQPMPLLTNTPFIVTGSGKFFRNVQLDPAANLGVVKIDSDGAGYHILWGLTHDAVPTSELPAHFLSHCERIKATHGKDRVIMHCHATNLIALTYVLENNTALITRKLWEGSTECLVVFPDGVGILPWMVPGTDEIGQATAQEMQKHSLVLWPFHGVFGSGPTLDETFGLIDTAEKSAEVLVKIYSMGGMKQTITREELVALGKRFGVTPLASAVALY
Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.
C0Q3L1
Q38X91
AROD_LATSS
Type I dehydroquinase
Latilactobacillus
MHLEFTTGQTQTAVSLMPRHLDDCLRELILINQKKDAIDILEWRLDYWQAPAQLLTAAEKIAALDLPLILTVRTTNDGGLASAQDYLTYYAPLIKAHIGQAIDLEWSLAAEQRHQLAELAHQQHYQVLLSHHDTVQTPDNDTLRTQLLAMQADPDADLLKLATTAQSPADTTRLLAATQSFTHQFDKPLTTMAMSEFGVASRIFGGQFGSAISFGYLETPSAPGQLPIEQLKGLLTTNQA
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Q38X91
A0RMQ7
RSMI_CAMFF
rRNA (cytidine-2'-O-)-methyltransferase RsmI
Campylobacter
MLYFLPTPIGNLDDISKRCLDVLELCEIIICEDTRVTKSLITLLNAKFGLQISPKEFYSLHTHNEKDFFDKFDKVRLETKICIYASDAGMPCISDPGISLVKFAQQNSIKYEVLSGANALLLAAAASGIIEKEFTFLGFLPNLGKERAIAIQNALNSLYPVIIYESPKRILSLIKSISEFDPLREVFIIKEATKKFEAKFKNSATNLLTQLENSNLNGEWCVVIDRSANKALERITTKDIMELDLPLKQKAKLISKITGENAKKIYQNLIT
Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
A0RMQ7
Q82SI9
YBEY_NITEU
Endoribonuclease YbeY
Nitrosomonas
MPTRNMPLTKNPVESPDHEQELVLTVQYVADKTDIPNRRLFRKWVKAALSKPAEVVIRIVDRQEGEILNRDFRGKSSATNVLTFVYDDDVPLLGDIVLCAPVICNEAQQQGKDLTAHYAHLTIHGILHLQGYDHIRDEDAVVMESLETEIITRLGYPDPYVIQH
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q82SI9
Q180P4
PFKA_CLOD6
Phosphohexokinase
Clostridioides
MKTIGLLTSGGDAPGMNAAIRAVVRSAIYYGCKVYGINRGYKGLLEEDLTEMNLSSVGDIIHRGGTILKSSRCEEFKTEEGRLKAVKILKKYKIDCLVVIGGDGSFAGAQKLSDLGFPAIGIPGTIDNDLAYTDYTIGFDTAMNTIIDAIGKIRDTSSSHERVNIVEVMGRHCGDLALYAGLAGGAETIIVPEVEITVDEVALRLKTTQKRGKRHSIIVLAEGVGSASDLEKELKKESGADLRVTVLGHVQRGGSPTVSDRILASRLGVRAVELLLDGKSARVVGIKENKIIDLEISEALAQKKVFDKEAYEMAKILSI
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
Q180P4
A4FWU0
BIOB_METM5
Biotin synthase
Methanococcus
MKEIKLNSDSLEIYEKSASKKLNRNDLIDLWNLDLNDLLDISYALKKLFNKDKIDLCSIMNAKSGICPENCIFCSQSKHNSSKIDTYELKSKEEILKNAKSVEKYSNRFSIVVSGKTVTDLEFEKIIESIEEIQNKTKLKVCVSLGLLNKDQLKALNEKNVRIHNNLETSENYFKNICTTHDYNDKIKVILEAKKIGLEMCSGGIFGMGESIDDRINLFLDLKKLGVDSIALNLLNPIYGTKIYDRINSGDISPINSIGALKSLCIARITLPNKVIRLCGGREHVLKDMQKYSLLAIDGLMIGNYLTTNGQNIQSDLKMIEEMGFER
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
A4FWU0
Q8RWL5
CLT3_ARATH
Chloroquine-resistance transporter-like transporter 3
Arabidopsis
MATTSRRFTTGLFASITSVKSHSANRPQSISLIRRNHIDHRLPLIVPSSRRWIIQAARSWDGFDDGAEAEIKKPGAYGYAIGDNEIEGSSSSTVHVIDGEHVKTAEIVIWAAVTAAFGVGNRVMYKLALVPLKEYPFFLAQLSTFGYVAVYYTILYFRYRAGTVTDAMLSVPKSPFLIVGILEALAAAAGMAAAANLSGPSTTVLSQTFLVWQIFFSIIFLGRRYSVNQILGCTLVALGVIVSVASGSGAAHSLNEAGVLWILLMVLSFLLQGAGTVLKEVIFIDSQRRLKGASLDLFIVNSYGSAFQAICIALLLPFLSKLWGIPFNQLGTYLKDGAVCFLNNGTITKGCDGAPFLPLLFVIMNIGYNIALLRLLKISSAVVSCLASTVSVPIAVFLFTMPLPYLGVASSLPKGFMGGTIILVLGMILYSWTPHGANSSHTDSVIPSPPPT
Involved in thiol transport from the plastid to the cytosol. Transports probably both glutathione (GSH) and its precursor, gamma-glutamylcysteine (gamma-EC). Exhibits some functional redundancy with CLT1 in maintaining the root GSH pool.
Q8RWL5
A1VM56
PNP_POLNA
Polynucleotide phosphorylase
Polaromonas
MSIFNKVTKSFQWGQHKVTMETGEMARQAGGAVLLDMDGTVVLATVVAKSDAKPGQDFFPLTVDYLEKTYAAGRIPGSFFKREGRPSEFETLTSRLIDRPIRPLFPEGFFNEVQVVIHVLSLNPEVEGDIPALIASSAALSISGIPFNGPIGAARVAYINGEYVLNPGKTQLQNSTMDLVVAGTEAAVLMVESEAKQLSEEIMLGAIVFGHEQGNIAINAIHELVRDAGKPVWDWKAPAKDEVLIAKVVALAEEKLVAAYQIRNKQARTHATRQVTTWTKMGLKAEGVEFDGVAVEGMLFDIEAKIVRSQILAGDPRIDGRDTRTVRPIEIRNSVLPRTHGSALFTRGETQALVVTTLGTERDAQRIDALSGDYEDRFMLHYNMPPFATGETGRVGSPKRREIGHGRLAKRALIAVLPSKEEFPYTMRVVSEITESNGSSSMASVCGGCLSLMDAGVPMKAHVAGIAMGLIKEDNRFAVLTDILGDEDHLGDMDFKVAGTTFGITALQMDIKIQGITKEIMQVALAQAKEARMHILGKMQEAMGQANAEVSDFAPRLYVMKINPEKIRDVIGKGGAVIRALTEETGTQINIEEDGTITIASNDSAKADEAKRRIAEITAEVEIGKVYEGAITKILDFGALVNLMPGKDGLLHISQIAHERVEKVTDYLSEGQIIKVKVLETDEKGRVKLSMKALLDRPSQHQG
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
A1VM56
O74988
COX5_SCHPO
Cytochrome c oxidase polypeptide V
Schizosaccharomyces
MYLSKIICKKVPMKLLCTRNAATVSAAATNALQKEQPSGEAMIARPRLVDLDKRWGIMSQEEKDGLITDLYARQKQPWTTLSIEEKKAAYWIAFGEHGPRAFSHISQKTVFWGTVAGLTIGVVLFGLIRTQAAPSPRTMTREWQEKSNEYMKENKINPISGEASEGFKGRGQISGGIFSPSEKDKK
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
O74988
A6MVW5
ATPD_RHDSA
F-type ATPase subunit delta
Rhodomonas
MSSKNVKVAKPYADAFIEIANKGSVINDLNCIATALSESKDLQKAIANPLVSSAAKKDIIKSIFAGNVDENTVKFMMVLCDRGRIEYLDAIAETALILAYKQASIEMAYVASSVKLSSAQTEALVDKLKAMTKADQIKLELKVDESLIGGFKVQIGSRIIDTSVQNQLKQLSSYLGASVA
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
A6MVW5
O64518
MCA5_ARATH
Metacaspase-6
Arabidopsis
MAKKAVLIGINYPGTKAELRGCVNDVRRVHKSLVDRFGFSERNITELIDTDESSTKPTGKNIRRALLNLVESAKPGDVLVVHYSGHGTRLPAETGEDDDTGYDECIVPCDMNLITDDEFRDLVEKVPKEAHITIISDSCHSGGLIDEAKEQIGESTKKKPKKESGGSSGLGIKGFVREAVEEALESKGIAIPHHKDEKDENKTKELKLEDGAKVHVVNKSLPLQTLIDILKQNTGNNDIEVGKIRPTLFNVFGEDASPKVKKFMKVILTKLQEGKTEGGILGMIGKLAQEFLKHKLNDDEEYVKPAMKTHVGNKQEVYAGASNGSLADNGILISGCQTDQTSADASPQGHPEMAYGAFTNAVQIILEETKGMITYKELVLKARKLLKKQGFSQRPGLYCSDSFVNAPFIC
Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. May be involved in the modulation of programmed cell death activated by oxidative stress.
O64518
A2CC49
RS13_PROM3
30S ribosomal protein S13
Prochlorococcus
MARIAGVDIPRDKRVEVALTYIYGIGLTRAKTILTKSGVNPDIRVKDLEDGDVQKLRTALEAFTIEGDLRRQEGMALKRLQDIGCLRGRRHRMSLPVRGQRTRTNARTRRGARKTVAGKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
A2CC49
P0A132
IF3_PSESM
Translation initiation factor IF-3
Pseudomonas
MIIKREMRQDKRAAPKAPINENISAREVRLIGADGEQIGIVSIDEALRIAEEAKLDLVEISADAVPPVCRVMDYGKSIFEKKKQVAAAKKNQKQIQVKEIKFRPGTEEGDYQVKLRNLVRFLSDGDRAKVSLRFRGREMAHQELGMELLKRVEGDLLEYGSVEQHPKMEGRQLIMVIAPKKKK
IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
P0A132
B5Y963
RS13_COPPD
30S ribosomal protein S13
Coprothermobacter
MARIVGVELPDNKRIVFALPRIYGIGKSTAEDICEALGIDPMQKLGELTPEQINTLQDYITAHYKVEGDLRREVAMNIKRLMDIKCYRGIRHQRGLPVRGQRTRHNARTRKGPRKTVGAKKGKR
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
B5Y963
A0LQM0
HIS3_SYNFM
Phosphoribosyl-AMP cyclohydrolase
Syntrophobacter
MTLDPDFSKNDGLLPVIVQSADDDKVLMLAYMNELAWHRTLETGKAHYWSRSRRKLWQKGEESGNVQTIREILLDCDLDTILLKVVQTGGAACHDGYESCFYRRYADGKLEVVGKRVFDPKEVYKK
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
A0LQM0
P86197
ODP2_MESAU
Pyruvate dehydrogenase complex component E2
Mesocricetus
VPLPSLSPTMQAGTIARDVPLGAPLCIIVEKGRVFVSPLAKGIDLTQVKGTGPEGDIDSFVPSKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKEGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPITMLL
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
P86197
A1UUD2
DAPE_BARBK
N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
Bartonella
MPVLTDPVQLLQALIRCPSITPNEAGALSILEQFLRKMGFSVERPIFSDKNTADVENLYAKMGNKGPHLMFAGHSDVVPPGELDNWMYPPFEGIINQGKIYGRGAVDMKGAIACFIAALARVLEKQPIKGAVSLLITGDEEGPAINGTVKLLKWAAQKGEKWNAAIVGEPTSVKRVGDMIKIGRRGSISGIITVKGRQGHVAFPERAANPLPLAHKLIQALTDTALDQGTKNFQASNLELTTIDTGNSATNIIPAQTVIRFNIRYNDLWTKEALIAEIEKRLALVHSENNSNQYPYYQLEWIQNLGSVFLIKNDHLIEILSNAIEIVTGKRPECSTSGGTSDARFIKDYCPVVEFGLPGNTMHMVDECVTLDAMESLTVIYERFIIDFFA
Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls.
A1UUD2
Q5SXM2
SNPC4_HUMAN
snRNA-activating protein complex 190 kDa subunit
Homo
MDVDAEREKITQEIKELERILDPGSSGSHVEISESSLESDSEADSLPSEDLDPADPPISEEERWGEASNDEDDPKDKTLPEDPETCLQLNMVYQEVIQEKLAEANLLLAQNREQQEELMRDLAGSKGTKVKDGKSLPPSTYMGHFMKPYFKDKVTGVGPPANEDTREKAAQGIKAFEELLVTKWKNWEKALLRKSVVSDRLQRLLQPKLLKLEYLHQKQSKVSSELERQALEKQGREAEKEIQDINQLPEEALLGNRLDSHDWEKISNINFEGSRSAEEIRKFWQNSEHPSINKQEWSREEEERLQAIAAAHGHLEWQKIAEELGTSRSAFQCLQKFQQHNKALKRKEWTEEEDRMLTQLVQEMRVGSHIPYRRIVYYMEGRDSMQLIYRWTKSLDPGLKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQLIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIMMGKKQGLRRRRRRARHSVRWSSTSSSGSSSGSSGGSSSSSSSSSEEDEPEQAQAGEGDRALLSPQYMVPDMDLWVPARQSTSQPWRGGAGAWLGGPAASLSPPKGSSASQGGSKEASTTAAAPGEETSPVQVPARAHGPVPRSAQASHSADTRPAGAEKQALEGGRRLLTVPVETVLRVLRANTAARSCTQKEQLRQPPLPTSSPGVSSGDSVARSHVQWLRHRATQSGQRRWRHALHRRLLNRRLLLAVTPWVGDVVVPCTQASQRPAVVQTQADGLREQLQQARLASTPVFTLFTQLFHIDTAGCLEVVRERKALPPRLPQAGARDPPVHLLQASSSAQSTPGHLFPNVPAQEASKSASHKGSRRLASSRVERTLPQASLLASTGPRPKPKTVSELLQEKRLQEARAREATRGPVVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSGRLPAFGGVIPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPLPQPGPEKGALDLGLLSQEGEAATQQWLGGQRGVRVPLLGSRLPYQPPALCSLRALSGLLLHKKALEHKATSLVVGGEAERPAGALQASLGLVRGQLQDNPAYLLLRARFLAAFTLPALLATLAPQGVRTTLSVPSRVGSESEDEDLLSELELADRDGQPGCTTATCPIQGAPDSGKCSASSCLDTSNDPDDLDVLRTRHARHTRKRRRLV
Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Q5SXM2
Q15UB7
PYRD_PSEA6
Dihydroorotate oxidase
Pseudoalteromonas
MYAILQKFLFTQDAEWSHDFTINWLKRTQHNFLNVAYKQHIDDKPVEFLGITFKNPVGLAAGLDKNAECIDAFAAMGFGFIEVGTVTPKAQAGNDKPRMFRLPAGQAIINRMGFNNKGVDYLVEQVKQAKYKGVLGINIGKNKTTPEDEALNDYLICLRKVYAHASYVTVNISSPNTPGLRNLQYGDALTQLLEGLKEEQANLEVKHNKRVPILIKIAPDLEDSELDSMVDSFLTVGIDGVIATNTTLDRDRVKGQEHAEEAGGLSGSVLTDKSQQIVSSLCTKLAGNVPVIGVGGIDSPHAAKARIEAGSPLIQVYSALIYQGPKLIKEIVDSL
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
Q15UB7
A1UR46
ATPD_BARBK
F-type ATPase subunit delta
Bartonella
MSDSFSLLPLPLVSQRYAHALFDLVQKEGYVGDVEKALASFQVILEQDKALKHLVQSPFLSVKEQVKAVCAVCENLGLAHKKAGQILRNFLCVVAANRRLSALSGILQAFQRRVALSRGEVSAQVISAHPLDADQKKELCVALESVVGGKVTLRLSVDPAILGGLIVRLGLYQIDTSLATQLSSLKLALKKEVS
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
A1UR46
Q5R109
PDXJ_IDILO
Pyridoxine 5'-phosphate synthase
Idiomarina
MKGLRLGVNIDHVATLRNARGVRYPDPVAAAAIAEQAGADGITIHLREDRRHITDRDVAMLKQTLNVPMNLEMAVTEEMLDIAIKTQPTYSCLVPEKRQELTTEGGLNVAGQLETITDATRRLSDAGIQVSLFIDADHEQIDAAKKAGAPIVELHTGQYAEAETEEQRTVELARLMEASEYAHSIGLQVNVGHGLHYHNTLEVAEIPQVCELNIGHSIIARAVLVGLDQAVRDMRNILDKAR
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
Q5R109
Q8IUC8
GLT13_HUMAN
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13
Homo
MRRFVYCKVVLATSLMWVLVDVFLLLYFSECNKCDDKKERSLLPALRAVISRNQEGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEGCKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENYVKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGTGHVINKNNRRLAEVWMDEFKDFFYIISPGVVKVDYGDVSVRKTLRENLKCKPFSWYLENIYPDSQIPRRYYSLGEIRNVETNQCLDNMGRKENEKVGIFNCHGMGGNQVFSYTADKEIRTDDLCLDVSRLNGPVIMLKCHHMRGNQLWEYDAERLTLRHVNSNQCLDEPSEEDKMVPTMQDCSGSRSQQWLLRNMTLGT
Can glycosylate both unmodified peptides and glycopeptides that already contain an O-linked GalNAc sugar. Transfers GalNAc to Thr-/Ser-rich tandem repeats GTTPSPVPTTSTTSAP of MUC5AC, specifically on Thr-3 of non-glycosylated MUC5AC peptide, on Thr-12 and Thr-13 of preglycosylated MUC5AC at Thr-3 (MUC5AC-3), on Thr-3 of preglycosylated MUC5AC at Thr-13 (MUC5AC-13) and on Thr-12 of preglycosylated MUC5AC at Thr-3 and Thr-13 (MUC5AC-3,13).
Q8IUC8
Q2IWG9
SURE_RHOP2
Nucleoside 5'-monophosphate phosphohydrolase
Rhodopseudomonas
MRILCTNDDGIHAPGLKIVEDIARALSDDVWVVAPELDQSGVSHSLSLNDPLRLREVGPRHFAVRGTPTDCVIMGARHILADKAPDLVLSGVNRGRNVAEDVVYSGTIAGALEGTILGLPSFALSQEFTLETRNAPLWDTAKAHGPEILRKAIKAGVPKNTVININFPACAPDEVAGVQVTRQGKRNQGFLRVDERHDGRGNPYFWIGFERVAVVDMPAEGTDLAALAAKYISVTPLRLDRTDEAFSATLAKTLG
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Q2IWG9
Q043G6
ADDA_LACGA
ATP-dependent helicase/nuclease AddA
Lactobacillus
MTNFTKEQDQAINDAGKDILVSASAGSGKTTVLVERVLKKILSGTPVSSLLIITFTKAAAREMKERIKQKISDQLEIEPDNQFLRSQLLDVDTANISTIDSFCLDVIRRFYYVIDLDPQFSVLTDETQAELLKERALREIEADYLEGDNQDFQDFYDNFSGDRDAEGARNLLLQLYNTATTEPNYEKFLDNLPTCYEVGDNLIRSNLWQQQIKPLLLKEISDLKAEVEALLAEPEINSSDLVKVKENYDIFSNRLDSFWESLNTDQPYNEIRANLMNCKFEKAVRKSKKWSDESIEVYQDSQDLKLDLNDQLKKIFASFFVVEEKEQIAVLQKSEKIVKTIVAAEKKLIQKFSQLKREQNLIDYSDMEQFAFSILTTDTSNAHIAQEYYQEKFNEILIDEYQDVNALQENIIKAIKKKGQNTLFMVGDVKQSIYGFRQARPDLFLSKYHTYGKDNDSEKIILADNFRSTKRVTKTVNDLFNPILTTNFGGIDYKKEGQLQFGASYYPSDLPTASEYIFTDKKQTQSAYEDQYGDEMDFSEVQMVIARIKQLKAENFQVWDRRTQLKRPLEYSDIAIITRTRSDNLQVMQEFAKADLPLFVTDAQNYFQTFELIMIMNYLRLIDNPQQDIPLVAVMRSPLFNFKEPELAQIRVKTPAGNFYTALTSFASVNSSLGKKCKEFLQQLETLRSFAATHRISELIWSIYEKTHLLEIVTGLPNGQQRRVNLESLYERATSYESAGFKGLYQFISFIERMRKNQKDLAQPLLSDKADNAVKLMTIHASKGLEFPIVFVMGLGHQYQTRDLSGNFTISQNELGLTIKEKNYRIDSLVKSLADVQKRQQMLEEEARILYVGLTRAQQKLILVASVNEIENKRKKWVSELDQKKDIIPLVKKINAQSPLDFLGPKLEQKHEFDQTIRDMTSALEEQDKLYYLKFNLDLEPEKIKDQNEDSQEVNSNVNKVVKELYNFKYPFEDATKTTAYQSVSEIKKAFNDPIDTELENSRLISSSNRYLQPIDETPTFLEGQKFTGAEIGTAMHLVLQYYNYEGNKDQENLDQEIDQLVELGKLNSLMVPHLSKEALNWFVMSDFAKEFWKQPDKLHRESQFSSLVNASELFNDFSDPSAKVLVHGTVDGYFEAKDGLILFDYKTDFVDKTNEEQAIEKIKQKYTGQLRLYEQALNEMNNDKKVIGKYLILLDARKVVPVD
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
Q043G6
Q8YLJ5
RL7_NOSS1
50S ribosomal protein L7/L12
Nostoc
MSAATDQILDQLKSLSLLEAAELVKQIEEAFGVSAAAPAGGMMMMAAPGAAAAAEPVEEQTEFDVVLESVPADKKIAVLKIVREITGLGLKEAKDLVEAAPKAVKEAIAKDAAEDAKKRIEEAGGKVTVK
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
Q8YLJ5
O73819
GNA14_XENLA
Guanine nucleotide-binding protein subunit alpha-14
Xenopus
MAGCCLSAEEKESQRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYTDEDRKGFTKLVYQNIFTSMQSMIRAMDTLRIQYTSEQNMENALVIREVEVDKVSSLERKHVEAIKKLWEDEGIQECYDRRREYQLSDSTKYYLSDIDRISNPGFIPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFQNSSVILFLNKKDLLQEKIMYSHLIDYFPEFTGPKQDSQAARDFILKLYQDQNPDKEKVIYSHFTCATDTENIRFVFAAVKDTILQLNLREFNLV
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Mediates responses to trypsin.
O73819
P22520
CVAB_ECOLX
Colicin V secretion/processing ATP-binding protein CvaB
Escherichia
MTNRNFRQIINLLDLRWQRRVPVIHQTETAECGLACLAMICGHFGKNIDLIYLRRKFNLSARGATLAGINGIAEQLGMATRALSLELDELRVLKTPCILHWDFSHFVVLVSVKRNRYVLHDPARGIRYISREEMSRYFTGVALEVWPGSEFQSETLQTRISLRSLINSIYGIKRTLAKIFCLSVVIEAINLLMPVGTQLVMDHAIPAGDRGLLTLISAALMFFILLKAATSTLRAWSSLVMSTLINVQWQSGLFDHLLRLPLAFFERRKLGDIQSRFDSLDTLRATFTTSVIGFIMDSIMVVGVCVMMLLYGGYLTWIVLCFTTIYIFIRLVTYGNYRQISEECLVREARAASYFMETLYGIATVKIQGMVGIRGAHWLNMKIDAINSGIKLTRMDLLFGGINTFVTACDQIVILWLGAGLVIDNQMTIGMFVAFSSFRGQFSERVASLTSFLLQLRIMSLHNERIADIALHEKEEKKPEIEIVADMGPISLETNGLSYRYDSQSAPIFSALSLSVAPGESVAITGASGAGKTTLMKVLCGLFEPDSGRVLINGIDIRQIGINNYHRMIACVMQDDRLFSGSIRENICGFAEEMDEEWMVECARASHIHDVIMNMPMGYETLIGELGEGLSGGQKQRIFIARALYRKPGILFMDEATSALDSESEHFVNVAIKNMNITRVIIAHRETTLRTVDRVISI
Involved, in conjunction with CvaA, in the secretion of colicin V.
P22520
Q6BV91
PRP45_DEBHA
Pre-mRNA-processing protein 45
Debaryomyces
MFSSLLPKPKYSSHEPTSRIKLKKVRAHEKSNQLVKLPENKSDIKVTHNPSNSESTISQLHLNPDGTLNYNLTIASSNSNSRKVQSSYEDTIPLKVKFPNLKHHFPRYTVETCPDDSLKECVEDTKAAINKMINEKMGVDEKTNNKKDDVTYIKYTSNNLVNDPEGSDDERGRERIIQIRNYQEDPMLPPKFKLRKNRHKNPSPPPPLLKSSNNEQTSKLTKEDQAKWQIPSAISNWKNNQGFTISLDKRMVAANGGSELATNDVNLEKFGELSQALENADKQAREEIKIRSEMLKQLAIKEQHEKENKLKELADIARSKKLNNKRPPNGDYDDVKKKTKY
Involved in pre-mRNA splicing.
Q6BV91
Q8D3Z2
DEOD2_VIBVU
Purine nucleoside phosphorylase DeoD-type 2
Vibrio
MATPHINAQPGDFAETVLMPGDPLRAKYIAETFLEDVKQVCDVRNMFGFTGTYKGKKVSVMGHGMGIPSACIYVHELIAEYGVKNVIRVGSCGAVRDDVNLMDVVIGMGASTDSKVNRIRFNDHDFAALADYGLLEEAVKQARAQNVPVKVGNVFSADLFYTPEADIFEKMEKLGILGVDMEAAGIYGVAADLKAKALTILTVSDHIIRGEKLSSEDRQKSFNDMMKVALETAINL
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
Q8D3Z2
C8WLM1
CGR2_EGGLE
Cardiac glycoside reductase operon protein 2
Eggerthella
MEYGKCRGIERGMGRRDFLKAATLLGATAAGAGMLAGCAPKSASEAQAQTAPAATGGLDPADVDWKYETDVVIVGSGSGGTCAAIEAAEAGADVVVFEKDKAMYGGNSALCGGYMLAAGWSTQEEITGYAGDTGEAFANQMLRWSQGLGNQDMIREACLRSGEAVDWMMDTGRTYEGASPLPPVWSCGDTEADVVPRSVYNHNAYGATEGHMATLKKRAESLSNIEIEMGCEVAHILKNAEGSVIGVQLADGSFAKARKGVVMACASVDNNLEMSKDLGLMQNVWGLTLEGAGLLAPGNPDMDSNTGDGVRMLREIGAELCMQQAVCMNDSIYVGGISDWGMSEILGKDVNIHDSSNIDAILVDKTGRRFCQDDAEWGYVMHECAQAAWKQGFTPDDPTTGYIFYVYDATGAPFFEMKGHTPDTCDTTFSADSVDGLAEFIGCDPTALASEVERWNSFCEAGLDADFGRRANMAPIATPPFYCDVVRPGPMGTFAGAKSNVEAEIIGLDGNPIPRLYGAGCIIGGNVSGAFYFGCGWSITNTVVWGREAGRNVAALEPWE
Involved in the inactivation of the cardiac medication and plant natural product digoxin, thus decreasing drug efficacy and toxicity. Catalyzes the reduction of the alpha,beta-unsaturated butyrolactone ring of digoxin to the inactive metabolite dihydrodigoxin. Likely uses the cytochrome Cgr1 as the physiological electron donor, encoded by the adjacent gene in the locus. Only reduces digoxin and other cardenolide toxins, such as digitoxin, digoxigenin, ouabain and ouabagenin. Therefore is a specialized enzyme present in some gut bacteria E.lenta that protects their human host against ingested plant toxins.
C8WLM1
Q30QB8
SURE_SULDN
Nucleoside 5'-monophosphate phosphohydrolase
Sulfurimonas
MRYKILVTNDDGYEAKGLRALVKALKELEDVEVMVVAPASEKSACGHSLTLVRPLRFVGVDDNFFKLDDGTPSDCVYLALSTIYVDSKPDLLISGINRGSNMGEDITYSGTAAGAMEGVLHDVPSIAISQVMDFSDPQGDFTLAQKVIKELVIKIKNGSFPLPQREFLNVNIPPDLDSTDNRDAKMVVTYAGYRFYANDSHIHRNPRGEEFYWLGLHPLDFLPREGIKGISDYEAIEAGNISITPIQLDMSAYKSMNKLKEWIE
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Q30QB8
C1CVN9
EFTS_DEIDV
Elongation factor Ts
Deinococcus
MMESIKKLRELTGAGMMDVKKALSDAGNDEDKAVALLRERGIVKAAKKADREAKEGIVRFVVEGNRAAIVEVNSETDFVARNSDFQALVEKLAQTALSAKTNDVEEFRNFSMDGETVGTVVAAAAGKIGENLVLNRVAYIEGDKVAGYVHSNGKIGVLVDVAGGDETKAKDVALHVAAERPQYLSRDEVNQDDIEKEREILTNKALNEGKPQQIVEKIVSGQIGKFYEEKVLPEQRYVKDNSMTVGQYLGDASVKRFVRFEIGA
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
C1CVN9
Q5GYM5
LEXA2_XANOR
LexA repressor 2
Xanthomonas
MDLTDTQQAILALIAERIDADGVPPSQTEIARAFGFKGVRAAQYHLEALEQAGAIRRVPGQARGIRLAGQGGQTRAAAVSEPVRDDVLRLPVLGRVAAGLPIGADIGSDDFVVLDRVFFSPSPDYLLKVQGDSMRDEGIFNGDLIGVHRTRDARSGQIVVARIDEEITVKLLKIGKDRIRLLPRNPDYAPIEVLPDQDFAIEGLYCGLLRPNR
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Q5GYM5
Q2ST42
UPP_MYCCT
UPRTase
Mycoplasma
MAFTEIKHPLIIDKLTRMRKTETSSKDFRENLSEIAQLMVYEIFRDLKLESVDIETPVSKTTGYTINQPVVLVPILRAGIGMLDGIQKLIPTARIAHIGLYRDEETLETHQYFAKTTKDIDKSYVIVVDPMLATGGSACKAIDIVKQWGAKEIKFVCLVAVEPGIKRLQEQHPDVEIYAASKDEKLNEKGYIVPGLGDAGDRIFGTK
Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.
Q2ST42
P18863
HXB8_RAT
Homeobox protein R1A
Rattus
VLSPIPSSRRTQRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKENNKDKFPSSKCEQEELEKEKLER
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
P18863
A6VJ76
DPCKG_METM7
Dephospho-coenzyme A kinase
Methanococcus
MYLLTDEVARELKKPFGKVYKELPSIDGKVVSIGDVTTKHLLSNGIIPNLSILDFKTKRNIPVNIPHKFKTIFEVENPQGCISDEAIERIKYLSTIHDRDMALIIKGEEDLLTIPVIKYFPEDTSVIYGQPDEGMVLLKITDELKQKIEKLLKDMEER
Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
A6VJ76
Q6FTG6
FYV10_CANGA
Protein FYV10
Nakaseomyces/Candida clade
MAETTSLINEPDVDFHLKLNQHSFNIPYEQLQRNSRYLNRLIEKEIDELNSHYERLNIALGSGNIEGDKKALQELKDIIRSVEIFEKRLQKRVNEEVPILKRLEVRINFFKELENAKQQVADITPLMEWYLKFTNILIGDYLTRHTTSNSSPELGLPGVTFLEQEGIQDLLDTDILLTGNRISTALVDNHDLRPLLDWINDSKSYLKKNGSRLEFEARFQQYIELLKASEYEEAIKCFQDYLLKFVNTNFNELTHASGLLLSINYCKEIMKAKASERSAILTKDDGNPLENEIRAYKYFFHKKPKIVEQQHVKPVDLSYMNLSQNTDFEKYMLLLDDKRWGLLNELFLKDYYSLYGISQNDPLLIYLSLGISTLKTRECLHHRRVAKSSSPLVDKKVEEEVLQNSCPVCDKTFAPIAESLPFAHHTQSQLFDDPIMLPNGNIYEAKRLKRLAKYLVDIKAIELGETEVIDPIDKQIYNEADFITMYPT
Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.
Q6FTG6
Q0C1A1
TRPD_HYPNA
Anthranilate phosphoribosyltransferase
Hyphomonas
MSESALNTAIQAIARGLPLEESVLEGAFDTLLSGEAAPEEVGAFLAGLTVRGETANELIAGARIMRRHGRSVSVEGPLLDTCGTGGLPWKSLNTSTASAIVIAAAGGRVAKHGNRSVPPKTGSADVLEALGLQLELSDTAFKSCLEIAGVGFLFARSYHSAMRHVAPIRHKLGIRTIFNLLGPLSNPAGAEYSVLGVYDKQWVTPMAEALKALGTRCAWVVHGLAGIDEISISGPTDVCEVTPASIRHFQITPSDAGLPSHPLSTLEGGAPEENTAAIRDLLDGREGPFRDIVLINAAAGLHVSGMVADLPAGVQRAAQAIDSGAARETLNTLVRTSRESD
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q0C1A1
B8J7G5
SSRP_ANAD2
Small protein B
Anaeromyxobacter
MKGKAGGKAADAAEKVAASNRRARFDYDVEDTWEAGLVLTGSEVKSLREGNVNLSDAYAMPRGEELWLLNCRIGEYQQAAHFGHAPLRDRKLLMNRAEIDRVRGKVEQRGYTLVPLRIYFKQGWAKVELGLARGRSHEDRRGAIAERESKREMDRALARGRRR
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
B8J7G5
Q9EPB8
V1R54_MOUSE
Vomeronasal type-1 receptor A9
Mus
MNKMNRLSHNTEIRNAIYSGVGIGISGNSFLLLFHIFKYIRGQRSRHIDLPIGLLSLIHLVMLIAMSLVATDIFMPWGRWGDTTCKCVISLYRFCRSLSLCATSLLSILQAVTLNPRNSCLEKFKRKSPHYMLGCLLFLSVFYTFISSPLATYITAKSNLTSPSFTYITTSCSLAPMSYSFHLTVFILLTSRDVIFVGLMLLSSGYMVTFLGRHKKQSQFLHITSFSLKPSAEKRAMRTILCLMSFFVLMYTLDSIVSYIRSIDDGQIFYCVHIFTAHGYATVSPFLILSTEKYIINIFRSTFGRMVTIILLRNR
Putative pheromone receptor implicated in the regulation of social and reproductive behavior.
Q9EPB8
Q8D3J8
ATPL_WIGBR
Lipid-binding protein
Wigglesworthia
MNSINADLLYISAAIIMGFASIGAAIGIGILGGKFLEGAARQPDLIPTLRTQFFIVMGLVDAIPMISVGLGLYLIFAAS
Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.
Q8D3J8
B8J8F0
MURB_ANAD2
UDP-N-acetylmuramate dehydrogenase
Anaeromyxobacter
MTWRDEIARRVRGEHLRDAPLAPRTAVRVGGPADLLCRPADGDALSALLRAVRELGVPLSVLGGGANTLVADAGVRGVVLRLPQEFPGESTDGDTLVLSAGAPISRLPARAHAHGLVGMEFLGGIPGTLGGAAAMNAGTRLGEMKDVVTRLELATPDGTGFVPASALGYAYRTCRLPPGAVIARVEVRLHPGDVAASEALMREDRERRRATQPLYRPTFGSTFTNPPGEYAGRLVEAVGLKGHRVGNAIWSPVHANFVTNLGGATARDVLALVRLARARVQERFGIALETEVRLLGEFLEEDLEGLDGHAAAGGGPGAASGGVRPPEAT
Cell wall formation.
B8J8F0
Q56336
CFPA_TREPA
Cytoplasmic filament protein A
Treponema
MASLDLPKSPNVFHPEKPSAVGSRNSLAQDCRDQQQEVNQLIEEETNKILHHLNTKLPKEVLERLDVMGGLKEKLYNYFNQNYQNMFNRYMVTAEDEMLKKVRGFIDREEMKVLNRYTPKEIAILLDEVAGADKFNTGEIEKSMVNMYGHLQGHIQRGVNELETHTNSLLRQKVDVGAFVRGENAYAVVKCAFKDNLARPKTVTDVKLSINILDSELVSPIFHYQTTVAYLIKDLISNHYIDAIDKEIDRVKDELIDQGKEEMSDSSIIFEKMKMVSDFTDDDCENPDSKRYELISRELMERISNLRAEIDPETFDQLNVRENIKKIVDLENIRNRGFNTAINSITSILDTSRMGYQYIENFKNARELILREYDDTDISNLPDERYQLRLKYLDNAQLIEERKGYEVMLRSFETEVDHLWDVLRTKYDKSKASRFMAKITDFDDLAKVYKKHIKKHYKDKTGEPVYEDIAKVWDEIAFVKPAETEVERMNRTFVYEKDKMRRKLILMRGKLKGMYDYQYPIERRVMEERLAFLESEFNRFDYLVNPFHLQPGLLLDIDITSIKRKKATLDGMANVLNEFLHGISKGFADAAFASFSRRRSTVRADIGQSFASDGSADQKESSGRVAFMDMVNETPALESSVAAEQVDVRSDVGMKTRKAGAVDAGKGRRGRRSAIREL
Component of the cytoplasmic filaments that run the length of the organism just underneath the cytoplasmic membrane.
Q56336
Q9US60
KLP3_SCHPO
Kinesin-related protein 1
Schizosaccharomyces
MTSIKVVCRIRPTNQLEQDLGGNNVIYPLNDSTVHIETSDYSGNFVFDRVFHPSSTQNDIFSYSIESTVDDLFLGYNGTVLAYGQTGSGKTYTMMGIENNFEKEGMTPRMLRRIFDKIRDSPSTTEYEVKVSYMEIYMEKIHDLLSEKNDRLTVHEDKLQGVYVQGLKTIYVSSETEALDILNKGMGSRAVASTSMNAQSSRSHSIFVLEVVQTDTESGETRRGRLFLVDLAGSESVGKSGAVGQTLEEAKKINRSLSTLGMVINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSYNATETLSTLRFGHRAKSIKNKAVVNSELSVDEMKRQLYIYKDALSRCVCGARINNNLDYNNCHSNVWSGEHSLTLSNLAEKSNLKEAEIIQGNRTIQESNNDRDESTVASIHRHNFDSDSINRLYAEAQLELKQRDGVLSSTKQQLSDLMTALGDAQERYVELVKNHRVNSNLTANNSLNDKPGFTIEQKDKNFSINNERNNFLQKLSTLDSSLAALVNVQRKLIKALISKERPQNGTVIKKIQGGT
Cytoplasmic motor that could play a role in Golgi membrane recycling.
Q9US60
Q9RME2
SERC_ALKAL
Phosphohydroxythreonine aminotransferase
Alkalihalobacillus
MVKQVFNFNAGPSALPKPALERAQKELLNFNDTQMSVMELSHRSQSYEEVHEQAQNLLRELLQIPNDYQILFLQGGASLQFTMLPMNLLTKGTIGNYVLTGSWSEKALKEAKLLGETHIAASTKANSYQSIPDFSEFQLNENDAYLHITSNNTIYGTQYQNFPEINHAPLIADMSSDILSRPLKVNQFGMIYAGAQKNLGPSGVTVVIVKKDLLNTKVEQVPTMLQYATHIKSDSLYNTPPTFSIYMLRNVLDWIKDLGGAEAIAKQNEEKAKIIYDTIDESNGFYVGHAEKGSRSLMNVTFNLRNEELNQQFLAKAKEQGFVGLNGHRSVGGCRASIYNAVPIDACIALRELMIQFKENA
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Q9RME2
P56831
IFNT3_BOVIN
Trophoblastin
Bos
CYLSEDHMLGARENLRLLARMNRLSPHPCLQDRKDFGLPQEMVEGSQLQKDQAISVLHEMLQQCFNLFHIEHSSAAWNTTLLEQLCTGLQQQLEDLDACLGPVMGEKDSDMGRMGPILTVKKYFQDIHVYLKEKEYSDCAWEIIRVEMMRALSSSTTLQKRLRKMGGDLNSL
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
P56831
P59198
LPXM1_SHIFL
Kdo(2)-lauroyl-lipid IV(A) myristoyltransferase 1
Shigella
METKKNNSEYIPEFDKSFRHPRYWGAWLGVAAMAGIALTPPKFRDPILARLGRFAGRLGKSSRRRALINLSLCFPERSEAEREAIVDEMFATAPQAMAMMAELAIRGPEKIQPRVGWQGLEIIEEMRRNNEKVIFLVPHGWAVDIPAMLMASQGQKMAAMFHNQGNPVFDYVWNTVRRRFGGRLHARNDGIKPFIQSVRQGYWGYYLPDQDHGPEHSEFVDFFATYKATLPAIGRLMKVCRARVVPLFPIYDGKTHRLTIQVRPPMDDLLEADDHTIERRMNEEVEIFVGPRPEQYTWILKLLKTRKPGEIQPYKRKDLYPIK
Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)-lipid A. Can probably also catalyze the transfer of myristate to Kdo(2)-(palmitoleoyl)-lipid IV(A) to form the cold-adapted Kdo(2)-lipid A.
P59198
Q14558
KPRA_HUMAN
39 kDa phosphoribosypyrophosphate synthase-associated protein
Homo
MNAARTGYRVFSANSTAACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRNITVDD
Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis.
Q14558
O02100
HOP1_CAEEL
Presenilin hop-1
Caenorhabditis
MPRTKRVYSGKTITGVLYPVAICMLFVAINVKLSQPEQQEQSKVVYGLFHSYDTADSGTITLYLIGFLILTTSLGVFCYQMKFYKAIKVYVLANSIGILLVYSVFHFQRIAEAQSIPVSVPTFFFLILQFGGLGITCLHWKSHRRLHQFYLIMLAGLTAIFILNILPDWTVWMALTAISFWDIVAVLTPCGPLKMLVETANRRGDDKFPAILYNSSSYVNEVDSPDTTRSNSTPLTEFNNSSSSRLLESDSLLRPPVIPRQIREVREVEGTIRLGMGDFVFYSLMLGNTVQTCPLPTVVACFVSNLVGLTITLPIVTLSQTALPALPFPLAIAAIFYFSSHIALTPFTDLCTSQLILI
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function.
O02100
Q6CMV8
H2B2_KLULA
Histone H2B.2
Kluyveromyces
MAPKAEKKPASKAPAEKKPAAKKTSSSVDPSKKRTKARKETYSSYIYKVLKQTHPDTGISQKSMSILNSFVNDIFERIATESSKLAAYNKKSTISAREIQTAVRLILPGELAKHAVSEGTRAVTKYSSSTQA
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q6CMV8
Q2INL1
CHEB2_ANADE
Protein-glutamate methylesterase/protein-glutamine glutaminase 2
Anaeromyxobacter
MSLAGGDRPIRVLVADDSELFRELLARVVAAEPGFEVAAVAADGDAAAAMARALRPDVVTMDLHMPDADGYSGIARIMAETPTPILVLTANPTEAAGFRALSLGALDILEKPSATADLGEYGRLIRSRLRLLAGVKVIRHLRGLRERRDAAPARAARVEVVVIGASLGGPRALAAVLRGLPPDFPAPIAVVQHIADGFTAGLAGWLAQESRLDVREARHGDPLRAGRVLIAPSGRHLVLGEGVARLSDAPPVDTFRPSVTPLFTSAARQYGRRCCGVLLTGMGRDGAEGLRVIKDAGGPTLAQDEATSAVFGMARAAVELGAVDRVLPVDEIPRALRELTR
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Q2INL1
B9DZF9
HEM1_CLOK1
Glutamyl-tRNA reductase
Clostridium
MIQLIGIKSQCDIGIRQKFSITSEVLEGKLKYINELVGSVLILSTCNRTEIYVDSNLEEKKLIDTVFYGLDWDYDLVSYIFYIKDKYAIKHLMEVSCGFHSKILGEDQILGQIKTAYDAALEAKTIKGKLQRLFQKAITCGKEFKHICESYRIPVSIPSIVAKEILNMDIRKYMIIGFGKIGQLLFKYLNNSQAQIIYIAVRDLNKVHDSYKKCGKIRFISFKDRKSYYNDIDCIVSCTSAPDKIISKGDLPCRKLTIFDLAVPEDIDRNVLDLDNVTLYDIDNISVIDEKNKAIRKKTMGKYRYILENHIDKFIKWEKLHQLSPEIQKVKKYGDEICEKRITTFKNKKHTKDNDILVKTMIESTARFYINRAIEVMKEEKLNGREEECLRLINKIFCK
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
B9DZF9
A0T0U9
PSBI_THAPS
PSII 4.8 kDa protein
Thalassiosira
MLTLKILVYTTVIFFVSLFIFGFLSSDPSRNPNRRDLE
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
A0T0U9
O94992
HEXI1_HUMAN
Menage a quatre protein 1
Homo
MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor . Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation . May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity . Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway .
O94992
Q1QP34
NUOD1_NITHX
NDH-1 subunit D 1
Nitrobacter
MVEAAPRNFTINFGPQHPAAHGVLRLVLELDGEVVRRVDPHIGLLHRGTEKLIEHKTYLQALPYFDRLDYVAPMNQEHAFCLATEKLLNITIPKRGQLIRVLYCEIGRLLSHLLNVTTQAMDVGALTPPLWGFEEREKLMVFYERASGARMHANYFRVGGVHQDLPSKLLDDIWDFCDPFLKVCDDLEGLLTENRIFKQRNVGIAEVKLADAWGWGFSGVMVRGSGAAWDLRKAQPYECYSELDFDIPIGKHGDCYDRYLVRMEEMRQSVRIMKQCLEKLRLPEGQGPVATRDHKIVPPSRAEMKRSMEAMIEHFKLYTEGHRVPAGEVYVAVEAPKGEFGVYLVSDGTNQPYKCKIRAPSFAHLSAMDFLTRGHMLADVSAIIGSLDIVFGEIDR
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q1QP34
Q1GHU0
RL9_RUEST
50S ribosomal protein L9
unclassified Ruegeria
MQVILLERVAKLGQMGDVVDVKPGFARNYLLPQGKAQTASDANIAAFEAQKAQLEARNLETKKEAEALGEKLGGQQFVVIRSASDGGNLYGSVTTRDAADVATEEGFSVDRKQVIIREPIKTLGLHIAEVHLHPEVMVTIELNVARSPEEAELQASGKSIQELAAEEEAAAEFEISELFDDIGGAASDDEGDAPAAAADEEESK
Binds to the 23S rRNA.
Q1GHU0
Q1I5F9
AMPA_PSEE4
Leucyl aminopeptidase
Pseudomonas
MELVVKSVAAVSVKTATLVVPVGEGRKLGATAKAVDLASEGAISAVLKRGDLAGKPGQTLLLHSVPGLKAERVLLVGSGKDEALGDRAWRKLAASVAGVLKGLGGSDAVLALDDIAVTGRDGHYGKYRLLAETLLDSDYVFDRYKSQKAEPRALKKITLLADKAGLAEAERAVKHASAIATGMAFTRDLGNLPPNVCHPSFLAEQAKGLGKAHKGLKVEVLDEKKIKELGMGAFYAVGQGSDQPPRLIVLNYQGGKKSEKPFVLVGKGITFDTGGISLKPGAGMDEMKYDMCGAASVFGTLRAVLELQLPINLVCLLACAENMPSGGATRPGDIVTTMSGQTVEILNTDAEGRLVLCDTLTYAERFKPQAVIDIATLTGACIVALGSHTSGLMGNNDELVGQLLDAGKRADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITAGCFLSRFAKAYNWAHLDIAGTAWISGGKDKGASGRPVPLLTQYLLDRAGA
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Q1I5F9
B4U8T1
RSMH_HYDS0
rRNA (cytosine-N(4)-)-methyltransferase RsmH
unclassified Hydrogenobaculum
MHKSVLLKEVTDFLSNPCPKIHIDATLGLGGHAKALLEVCKDTFLIGIDKDENAIEIAKEKLKGFNAVFYHGSFKDFDIVLKEEGLLYFDSILFDFGVSSLQLDEEEGFSFQREDFLDMRMDKRQQKTAYIVINTYKEKELADIFYKYGEERLSKKIARSIVEKRKKKPIETTKELVDIVSSCYPYKYSKINPATKVFQALRIEVNSELEDIKIALSKLLDFAKEGSKFAFISFHSLEDRLVKEFIKNNADKLKVCSKKPITPSDEELLYNKRARSAKLRCAKLCYNEKKDEAFDS
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
B4U8T1
Q1H4L2
RPOA_METFK
Transcriptase subunit alpha
Methylobacillus
MQNSPTEYLKPRVVDVDVISPVRARVTLEPMERGFGYTLGNALRRVLLSSIPGFAITEVKIDGVVHEYSTLDGVQEDVVDILLNLKGVALKLNSKNEATLTLNKSTEGVVTAGDFDTGHDAEIANPDHVIAHLTKGGKLNLEVKVEMGRGYQPVPQRRKTEDEDRVLGFIQVDASFSPISKVSYQVESARVEQRTDLDKLIMDVETNGIIEPEQAIRDAARILMGQLSVFADLEGAPSEVEVKQAPQVDPILLRPVDDLELTVRSANCLKAENIYYIGDLIQRTENELLKAPNLGRKSLNEIKDVLASKGLTLGMKLENWPPAGLEKV
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q1H4L2
Q9PCG4
FABH_XYLFA
3-oxoacyl-[acyl-carrier-protein] synthase III
Xylella
MSKRIYARIAGTGGYLPEKVLTNDDLAHIVDTSDEWIRTRTGIRERHIAAEGETTSDLAYEAAICALEAAEVRSADLDLIVVGTTTPDLIFPSTACLLQARLGAVGCGAFDVNAACSGFVYALSVAEKFVSSGCSKTVLVVGADTLTRIIDWSDRTTCVLFGDGAGAVVLKADEDTGILSTHLHADGSKKELLWDPVGVSVGFGEGKDCGALLMKGNEVFKYAVKALDRVVDETLEANHLDKHELDWLIPHQANLRIIEATARRLDMSMDQVVVTVDRHGNTSTASVPLALDEAIRSGRVQRGQLLLLEAFGGGFTWGSALLRY
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Q9PCG4
Q1Q8V3
NHAA_PSYCK
Sodium/proton antiporter NhaA
Psychrobacter
MAIHKIRAFFNLEASGGIVLALAAIAAMIIANTSLNTWYESFIHAPVAIQIGSFSIAKDAHHWINDGLMAVFFFLVGLELKREVLIGELSNVKQIILPAGAALGGMIMPAIVYLFFNYNEPEFWRGWAIPAATDIAFALGILSLLGNRVPNSLKVFLVSIAIFDDIGAIIIIALFYTNDLSLGSLAIAGLCLPFLYLLNRRNVTSITPYLLIGVIMWVAVLKSGIHATLAGVVLALFIPLFDRTDPEHSPLEELEHDLQNTVSYGILPLFAFANAGISLKGAGFGELFHSVPLGIAAGLFIGKQVGVMLMCWLIFKLGISTMPKGMNFKQIYGAALLCGVGFTMSLFIGGLAFAGETPLFDERLGIIMGSIVSGIAGYMMLKATLKDEVNVTSVDLTRHS
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Q1Q8V3
A6Q9N6
ANMK_SULNB
AnhMurNAc kinase
unclassified Sulfurovum
MNKERYIGIMSGTSLDGVDVVLCEIDKKSCLLKASVEYPFPDDLKKEILSMINGKCTLAQVGSVDVRLGILFSDAVNALLEIEKIDPKSIKAIGSHGQTLWHEPVGKYPFSMQLGDPSAIAVRTGIKVVADFRQKDMALGGQGAPFAPAFHAFLFGGTDASVSILNIGGMANITVLGKTLLGYDTGPGNVLMDMWVAEHKDVTYDRNGEWARSGEVIYPLLEAMLEDPYFSQPHPKSTGREKFNEAWLQKHLNAQHSTLNAHDVQRTLLELTAVSISNEVLKFNQDILLLCGGGAKNAFLVERLGTLMPNIQIGIANDADNIEAMTFAWLAYKRLHNEHVDLKDVTGARQNAILGGVYV
Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.
A6Q9N6
Q53EZ4
CEP55_HUMAN
Up-regulated in colon cancer 6
Homo
MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTTLLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK
Plays a role in mitotic exit and cytokinesis . Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis . Not required for microtubule nucleation . Plays a role in the development of the brain and kidney .
Q53EZ4
A5GCW2
HEM3_GEOUR
Pre-uroporphyrinogen synthase
Geotalea
MALKTLRIGTRASQLALWQANWVKSELEKRYPGLEVSLLKIKTIGDKILDVPLAQVGGKGLFVKEIEEAMLRGDIDIAVHSMKDVPTEFPEGLGLHCITEREDPRDAVISRGIKFADLPKGAKIGTSALRRQAQLLKIRPDMEMVIIRGNVETRINKLEAENLDAVILAAAGLKRLGFTDKVAEYLPTDLSIPAIGQGALGIECRLDNEEVKSAIDFFNHPATAYAVRAERALLWRCEGGCQVPIAAFGEVEGDQLKLTGFIASVDGKTSVKGSVSGPAEECEKLGITLAEQLLKDGGHEILAEVYQREVSREKEIPV
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
A5GCW2
A9AIP4
GUAA_BURM1
Glutamine amidotransferase
Burkholderia cepacia complex
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGIEDFTTAEGHGMLKVWMSHGDKVAELPPGFKLMASTPSCPIAGMADEARGYYAVQFHPEVTHTVKGRQMLERFVLQIAGAKPDWIMRDHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHIDASEQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKKLSNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREYADLLRRADAIFIEELRNTVATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVTALRAVQTTDFMTAHWAHLPYSLLGRVSNRIINEVRGINRAVYDISGKPPATIEWE
Catalyzes the synthesis of GMP from XMP.
A9AIP4
A9A1K7
LYSZ_NITMS
Putative [LysW]-aminoadipate/[LysW]-glutamate kinase
Nitrosopumilus
MITIKIGGSVVDDLHPSTIADIKKIAESEGVILVHGGGKEVTKVCEQLGKEPKFVTSPSGIKSRYTDKETAEIFTMVMSGRINKTIVQMLQKNGINAIGLSGVDAKVIEADRKKKLLIVNEKGRKQAIDGGYTGKIREVNASFIKSLLDQGLTPVISPIAISEESEFLNVDGDRAAAYVAGKVGSDKVLFITNVDGLLMDDKVVPKLTLAEAKEIRPKIGPGMEKKILASTEALDMGVTTALIANGQKENPISSAISHDNCTVIEHE
Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
A9A1K7
P74618
6PGL_SYNY3
6-phosphogluconolactonase
unclassified Synechocystis
MAPQVDVLINKQILIERALVCVTTRITKAIAERGQGTIALSGGNTPKPLYEALARQALPWEKIHVFWGDERYVSVDHPDSNQRMARLAWLDQVDIPEANIHPMPTAAADPEQDAQTYENELATFFQVEAGHFPAFDLILLGLGDDGHTASLFPHTPALTVGDRLITVGNKDGQPRLTFTIPLINRARSVVFLVAGASKQHALGEIFAPEADPQQYPARFIQPQGELIWLLDQQAGENLRP
Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
P74618
P25454
RAD51_YEAST
DNA repair protein RAD51
Saccharomyces
MSQVQEQHISESQLQYGNGSLMSTVPADLSQSVVDGNGNGSSEDIEATNGSGDGGGLQEQAEAQGEMEDEAYDEAALGSFVPIEKLQVNGITMADVKKLRESGLHTAEAVAYAPRKDLLEIKGISEAKADKLLNEAARLVPMGFVTAADFHMRRSELICLTTGSKNLDTLLGGGVETGSITELFGEFRTGKSQLCHTLAVTCQIPLDIGGGEGKCLYIDTEGTFRPVRLVSIAQRFGLDPDDALNNVAYARAYNADHQLRLLDAAAQMMSESRFSLIVVDSVMALYRTDFSGRGELSARQMHLAKFMRALQRLADQFGVAVVVTNQVVAQVDGGMAFNPDPKKPIGGNIMAHSSTTRLGFKKGKGCQRLCKVVDSPCLPEAECVFAIYEDGVGDPREEDE
Required both for recombination and for the repair of DNA damage caused by X-rays. Its function may be modulated by interaction with other repair proteins. RAD52 interacts directly with RAD51, via its C-terminus. Forms a nucleoprotein filament with DNA as an early intermediate in recombination.
P25454
O31269
ISCS_AZOVI
Cysteine desulfurase IscS
Azotobacter
MKLPIYLDYSATTPVDPRVAQKMCECLTMEGNFGNPASRSHVFGWKAEEAVENARRQVAELVNADPREIVWTSGATESDNLAIKGVAHFNASKGKHIITSKIEHKAVLDTTRQLEREGFEVTYLEPGEDGLITPAMVAAALREDTILVSVMHVNNEIGTVNDIAAIGELTRSRGVLYHVDAAQSTGKVAIDLERMKVDLMSFSAHKTYGPKGIGALYVRRKPRVRLEAQMHGGGHERGMRSGTLATHQIVGMGEAFRIAREEMAAESRRIAGLSHRFHEQVSTLEEVYLNGSATARVPHNLNLSFNYVEGESLIMSLRDLAVSSGSACTSASLEPSYVLRALGRNDELAHSSIRFTFGRFTTEEEVDYAARKVCEAVGKLRELSPLWDMYKDGVDLSKIEWQAH
Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur from cysteine to produce alanine via an enzyme-bound persulfide intermediate. Functions as a sulfur delivery protein for Fe-S cluster synthesis. Cluster assembly on IscU homodimers proceeds sequentially from 1 2Fe-2S per dimer, to 2 2Fe-2S per dimer and finally 1 4Fe-4S per dimer.
O31269
O64503
UTR1_ARATH
UDP-galactose/UDP-glucose transporter 1
Arabidopsis
MEVHGSGFRRILLLALCISGIWSAYIYQGVLQETLSTKRFGPDEKRFEHLAFLNLAQSVVCLIWSYIMIKLWSNAGNGGAPWWTYWSAGITNTIGPAMGIEALKYISYPAQVLAKSSKMIPVMLMGTLVYGIRYTFPEYMCTFLVAGGVSIFALLKTSSKTISKLAHPNAPLGYALCSLNLAFDGFTNATQDSIASRYPKTEAWDIMLGMNLWGTIYNMIYMFGLPQGIGFKAIQFCKLHPEAAWDILKYCICGAVGQNFIFMTISNFGSLANTTITTTRKFVSIVVSSVMSGNPLSLKQWGCVSMVFGGLAYQIYLKWKKLQRVEKKKQKS
Essential sugar transporter required for the transport of UDP-galactose and UDP-glucose from the cytoplasm into the Golgi and the endoplasmic reticulum, to ensure quality control of protein folding. Essential for pollen development and involved in embryo sac progress.
O64503
D3ZQE1
CEA16_RAT
Carcinoembryonic antigen-related cell adhesion molecule 16
Rattus
MKMPLTWGSWFLLSAWILNAGAEISITPEPAQPAEGDNVTLVVHGLSGELLAYNWYAGPSISLTFLVASYIVSTGDETPGPAHTGREAVRPDGSLDIHGALPGHTGTYILQTLNRQFQTEVGYGHMQVYEILAPPTVMANDTALVERRDTLRLICSSPSPAEVRWFFNGDALPVAVRLGLSPDGRMLTRHGVRREEAGAYQCEVWNPVSVSRSEPLNLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWAFNGKALKNGQDHLNISSMSADHEGTYTCIAKNSKTLLSGSASVVVKLSAAAVAMMIVPVPTKPMEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGNWIAGPAHTGREVGFANCSLLVQKLNLTDAGRYTLKTVTLQGKTDTLEVELQVA
Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.
D3ZQE1
Q3B327
CHED_CHLL3
Probable chemoreceptor glutamine deamidase CheD
Pelodictyon
MKKTAKTDTEDAFKFRSTFGEHYYDGYGARHETPHIVAYTGEVTAAGPGRVLISSPLGSCIAVCAYDPGTRVGGLAHVMLPGVPPAHAETGKDRYAAHALETLFSVMQNEGADPGNLLICLIGGANVLRREHDTIHIDNLRSLTSLILQRNLPICRTMTGGSERMMARMETKTGRIFQTTGNNPEEMLFDYFTHNIENPDN
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
Q3B327
Q4R5L2
ENOA_MACFA
Non-neural enolase
Macaca
MSILKVHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVANPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.
Q4R5L2
A5D2S0
IF2_PELTS
Translation initiation factor IF-2
Pelotomaculum
MVKKRVHELAKELKIESKEIINRLNQMGINVKSHMSTLEDGVVERLHQLYRPDQEEVKPAAAKPPAAGQTIKPEEVAPQAQPESRKKDAAMLDSQKPDRDRVQKNGRERAGKATRADHYKGAGLVERVPSRPPDRRFQERPKQSDKARPWGQPRADQGARLKTADFVQERTRSARAGQDYSQPEKVQQERVQDRQQKERPPFEKAQQPRPQHEHKPQDSVKERPHPERASREADNAKRAERLDKGAGKTAEIAYKSGLKALEKAQVGTKPQRAGERGARPGGLHETKPKKNLAPGDAGYAKLWQEQTPVIPQKLLDDRRRQTEEKVKVTEKQKQQAKSQKLVKSREKRNAMAELAEERLRPRPAVAGSRKKGAAKPQEQAQKPAQPLEKKPIVLGESTTVQELALKMHKSPAELIKKLMQLGVMATINQEIDTDTATILAGEFGYEVEVKLPVDIEAMLMQEPEDDPVSLQDRPCVVTVMGHVDHGKTSLLDAIRETNVTATEAGGITQHIGAYQVEHNGKKITFLDTPGHEAFTAMRARGARVTDIAILVVAADDGVMPQTVEAINHAKEAKVPIIVAINKIDKPGANPDRVKQQLTEHGLVAEEWGGDTICVNVSALKKEGLKDLLEMILLVAEMSELKANPNRPARGTVIEAELDKGRGPVANVLVQNGTLNVGDTLIAGAAFGRVRAMMDDKGRRIKKAGPSTPVEVLGFSEVPQAGDIFVVVEDEKLARTIVARRQARKREEELKSTARVSLADLFKHIQEGQIKELGIIIKADVQGSVEALRQALERLSTDEVRVNIIHGGVGAITETDVMLASASNAIIIGFNVRPDVNARKAAENEKVDVRLYRVIYDAIEDVKAAMSGLLEPEYREVTLGRAEIRKIFRSSKIGNIAGCYVLEGKIERDASVRVIRDGIVVHEGKLESLKRFKDDVREVVQGYECGIALEKFNEIQEGDIIEAFTVEAIKRQLT
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A5D2S0
P02710
ACHA_TETCF
Acetylcholine receptor subunit alpha
Tetronarce
MILCSYWHVGLVLLLFSCCGLVLGSEHETRLVANLLENYNKVIRPVEHHTHFVDITVGLQLIQLISVDEVNQIVETNVRLRQQWIDVRLRWNPADYGGIKKIRLPSDDVWLPDLVLYNNADGDFAIVHMTKLLLDYTGKIMWTPPAIFKSYCEIIVTHFPFDQQNCTMKLGIWTYDGTKVSISPESDRPDLSTFMESGEWVMKDYRGWKHWVYYTCCPDTPYLDITYHFIMQRIPLYFVVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMIFVISSIIITVVVINTHHRSPSTHTMPQWVRKIFIDTIPNVMFFSTMKRASKEKQENKIFADDIDISDISGKQVTGEVIFQTPLIKNPDVKSAIEGVKYIAEHMKSDEESSNAAEEWKYVAMVIDHILLCVFMLICIIGTVSVFAGRLIELSQEG
Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
P02710
Q9ZW24
GSTU7_ARATH
Glutathione S-transferase 25
Arabidopsis
MAERSNSEEVKLLGMWASPFSRRIEIALTLKGVSYEFLEQDITNKSSLLLQLNPVHKMIPVLVHNGKPISESLVILEYIDETWRDNPILPQDPYERTMARFWSKFVDEQIYVTAMKVVGKTGKERDAVVEATRDLLMFLEKELVGKDFLGGKSLGFVDIVATLVAFWLMRTEEIVGVKVVPVEKFPEIHRWVKNLLGNDVIKKCIPPEDEHLKYIRARMEKLNIKSA
May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.
Q9ZW24
P08566
ARO1_YEAST
Shikimate dehydrogenase
Saccharomyces
MVQLAKVPILGNDIIHVGYNIHDHLVETIIKHCPSSTYVICNDTNLSKVPYYQQLVLEFKASLPEGSRLLTYVVKPGETSKSRETKAQLEDYLLVEGCTRDTVMVAIGGGVIGDMIGFVASTFMRGVRVVQVPTSLLAMVDSSIGGKTAIDTPLGKNFIGAFWQPKFVLVDIKWLETLAKREFINGMAEVIKTACIWNADEFTRLESNASLFLNVVNGAKNVKVTNQLTNEIDEISNTDIEAMLDHTYKLVLESIKVKAEVVSSDERESSLRNLLNFGHSIGHAYEAILTPQALHGECVSIGMVKEAELSRYFGILSPTQVARLSKILVAYGLPVSPDEKWFKELTLHKKTPLDILLKKMSIDKKNEGSKKKVVILESIGKCYGDSAQFVSDEDLRFILTDETLVYPFKDIPADQQKVVIPPGSKSISNRALILAALGEGQCKIKNLLHSDDTKHMLTAVHELKGATISWEDNGETVVVEGHGGSTLSACADPLYLGNAGTASRFLTSLAALVNSTSSQKYIVLTGNARMQQRPIAPLVDSLRANGTKIEYLNNEGSLPIKVYTDSVFKGGRIELAATVSSQYVSSILMCAPYAEEPVTLALVGGKPISKLYVDMTIKMMEKFGINVETSTTEPYTYYIPKGHYINPSEYVIESDASSATYPLAFAAMTGTTVTVPNIGFESLQGDARFARDVLKPMGCKITQTATSTTVSGPPVGTLKPLKHVDMEPMTDAFLTACVVAAISHDSDPNSANTTTIEGIANQRVKECNRILAMATELAKFGVKTTELPDGIQVHGLNSIKDLKVPSDSSGPVGVCTYDDHRVAMSFSLLAGMVNSQNERDEVANPVRILERHCTGKTWPGWWDVLHSELGAKLDGAEPLECTSKKNSKKSVVIIGMRAAGKTTISKWCASALGYKLVDLDELFEQQHNNQSVKQFVVENGWEKFREEETRIFKEVIQNYGDDGYVFSTGGGIVESAESRKALKDFASSGGYVLHLHRDIEETIVFLQSDPSRPAYVEEIREVWNRREGWYKECSNFSFFAPHCSAEAEFQALRRSFSKYIATITGVREIEIPSGRSAFVCLTFDDLTEQTENLTPICYGCEAVEVRVDHLANYSADFVSKQLSILRKATDSIPIIFTVRTMKQGGNFPDEEFKTLRELYDIALKNGVEFLDLELTLPTDIQYEVINKRGNTKIIGSHHDFQGLYSWDDAEWENRFNQALTLDVDVVKFVGTAVNFEDNLRLEHFRDTHKNKPLIAVNMTSKGSISRVLNNVLTPVTSDLLPNSAAPGQLTVAQINKMYTSMGGIEPKELFVVGKPIGHSRSPILHNTGYEILGLPHKFDKFETESAQLVKEKLLDGNKNFGGAAVTIPLKLDIMQYMDELTDAAKVIGAVNTVIPLGNKKFKGDNTDWLGIRNALINNGVPEYVGHTAGLVIGAGGTSRAALYALHSLGCKKIFIINRTTSKLKPLIESLPSEFNIIGIESTKSIEEIKEHVGVAVSCVPADKPLDDELLSKLERFLVKGAHAAFVPTLLEAAYKPSVTPVMTISQDKYQWHVVPGSQMLVHQGVAQFEKWTGFKGPFKAIFDAVTKE
The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.
P08566
Q47R66
RS4_THEFY
30S ribosomal protein S4
Thermobifida
MRYTGPKVRLSRRAGVPLTRKAVKYFEKRPYPPGEHGRRVRRSTSDYAVRQAEKQKLRWYYDLSEKQLARVYENAKKRPGRTGEEMIAELELRLATVLLRAGFAASIYAARQFINHGHITVDGKKVDIPSYQVKPGQIVSVREKSRKLVPFIEAAEGVHADEKIASYLAVSHKDLTIAVVDRPKREQVPVPFDEQLVVEYYAR
With S5 and S12 plays an important role in translational accuracy.
Q47R66
Q6BSQ1
HAT1_DEBHA
Histone acetyltransferase type B catalytic subunit
Debaryomyces
MSDNSPITSITAASLQPELWTSSSNDALQIYITDSDGTALNFHPNFTYPIFGDSEQIFGYRDLVIFLCFDHCTFYPFLNVKYSDKLNDDTLEDPREKLLSYLPESTIFKDEVKWVDSINKEKEGFEIPGELVGNIFTHGDDKFGIYKLDLKNAQGLELHKRLQILVLLFIEAGSYIDHQDELWDIYVMYKVTDEKTPSIIGFCTAYNYWKYGGFEKFDSNQQEVRKKISQFIVLPMYQGLKLGGRFYNKLYEYWMQDPRVIEVVVEDPSESFDDLRDRCDLTRLCQNTIKVASVDLPLINTEWATKLRQEQKLEKRQFSRLLEMILIYQLEHNLTNITKKQVRLFIKKRLYEKNKEILDGLDEPTRLDKLQTAYASLESDYKRILSGLSLHKRALDSTEGSSKKSKPNV
Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.
Q6BSQ1
P71059
EPSJ_BACSU
Uncharacterized glycosyltransferase EpsJ
Bacillus
MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPDRSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQRLTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWYVWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSLTEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPNSPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQRGTMKGSAKQA
May be involved in the production of the exopolysaccharide (EPS) component of the extracellular matrix during biofilm formation. EPS is responsible for the adhesion of chains of cells into bundles.
P71059