accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
P10058
HBB_EUDCH
Hemoglobin beta chain
Eudyptes
VHWSAEEKQLITGLWGKVNVAQCGGEALARLLIVYPWTQRFFSSFGNLSSPSAILGNPMVRAHGKKVLTSFGDAVKNMDNIKNTFAQLSELHCDKLHVDPENFRLLGDILIIVLAAHFAKDFTPECQAAWEKLVRVVAHALARKYH
Involved in oxygen transport from the lung to the various peripheral tissues.
P10058
A1JJF4
RSMA_YERE8
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Yersinia
MNNRVHQGHFARKRFGQNFLNDQFVIDSIVSAIHPVPGEAVVEIGPGLGALTEPVAARMDHMTVIELDRDLADRLASHPQLKDKLTIHQEDAMKINFSELAELAGQPLRVFGNLPYNISTPLMFHLFSYTSAIRDMHFMLQKEVVNRLVAGPNSKAYGRLTVMAQYYCNVIPVLEVPPTAFTPAPKVDSAVVRLIPHVNTPNPVGDVRMLSRITTQAFNQRRKTVRNSLGDLFTPEQLIELGIDPILRAENISVAQYCKLANWLSAQSTPQE
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
A1JJF4
A8G1W5
ATPB_SHESH
F-ATPase subunit beta
Shewanella
MSTGTVVQVIGAVVDVEFPHDAVPQVYDALEIKSEGLVLEVQQQLGGGVVRTIAMGSSDGLRRGLEVVNSGSPITVPVGEKTLGRIMNVLGEPVDEAGPIGEEDRYVIHREAPSYEDQSSSTELLETGIKVIDLVCPFAKGGKVGLFGGAGVGKTVNMMELINNIAKAHSGLSVFAGVGERTREGNDFYYEMEDSGVLDKVAMVYGQMNEPPGNRLRVALTGLTMAEKFRDEGKDVLFFVDNIYRYTLAGTEVSALLGRMPSAVGYQPTLAEEMGVLQERITSTKTGSITSVQAVYVPADDLTDPSPATTFAHLDATVVLSRNIASLGIYPAVDPLDSTSRQLDPQVVGQEHYDVATGVQTQLQRYKELKDIIAILGMDELSDDDKTTVFRARKIEKYLSQPFFVAEVFTGSPGKYVSLKDTIRGFKGILDGEFDHLPEQAFYMVGSIDEAVEKANKK
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
A8G1W5
Q5L0S3
FMT_GEOKA
Methionyl-tRNA formyltransferase
Geobacillus thermoleovorans group
MTNIVFMGTPDFAVPILRQLLDDGYHVAAVVTQPDKPKGRKREPVPPPVKVEAERRGIPVLQPTKIREPEQYEQVLAFAPDLIVTAAFGQILPKALLDAPKYGCINVHASLLPELRGGAPIHYAIWQGKTKTGVTIMYMVERLDAGDMLAQVEVPIAETDTVGTLHDKLSAAGAKLLSETLPLLLEGNIAPVPQDEEKATYAPNIRREQERIDWTQPGEAIYNHIRAFHPWPVTYTTQDGHIWKVWWGEKVPAPRSAPPGTILALEENGIVVATGNETAIRITELQPAGKKRMAVGEFLRGAGSRLAVGMKLGEDHERT
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
Q5L0S3
Q09X07
PSAI_MORIN
Photosystem I reaction center subunit VIII
Morus
MTTISNLPAIFVPLVGLVFPAIAMVSLSLHVQKNKIF
May help in the organization of the PsaL subunit.
Q09X07
Q46TH1
FLHC_CUPPJ
Flagellar transcriptional regulator FlhC
Cupriavidus
MKTTAQTAPARSALQDASDTQLAIELIGLGARPQVVEAEVTLSRSRVYRLYRELTGGSPPKGMLPFSADWFVTWRPNAHASYLLSVHEYMQQRAGLPGIRAVLNSYRVYAEHMKANNEECLISFTRFWTLVRFCEGGLLQLSTCPCCGGRFVTHAHEPLASFICTLCQPPSRVRRSVRRETPHATANAPAAVLGNRPPVAMPGFGMVPAL
Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways.
Q46TH1
Q487K8
NAGB_COLP3
Glucosamine-6-phosphate isomerase
Colwellia
MQVIIFDNAQQVAENAAEWVAELINKKSNPVLGLATGSTPISLYQELVNKYKAGELSFSNTTSFNLDEYLGINEKNQQSYRHFMNENLFNHVDINKLKTFLPTCNQGENPREQGLDYEDKIAQAGGIDLQILGIGANGHIGFNEPTSSLASRTRIKTLTQQTLNDNSRLFAADEFQPTLAMTMGIATILDARYVLLMATGKSKAKAVKEMVTGPLSAVCPASSLQLHENAIVLLDKEAASELEDHEYYVWADKQNVKINQEFGLYHNY
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Q487K8
Q5B7I7
INPE_EMENI
Inp cluster protein E
Aspergillus subgen. Nidulantes
MAKETRFYPYTSNGGATLGVSGPDFAILAGDTRSTAGYNINTRYEPKVFTIQDARDRSIVISVIGFAADGRALKERLDAIVAMYKYQHGKNIGLRACAQRVSTMLYEKRFFPYQLQTMVAGIDADGQGAIYYYDPAGCIEKRSHCAAGEASSLMLPFLDSQAPRLQPLSLQTAQQLVRDAYTGATERHIEVGDHLQMLVVTREGVSEQLVDLKKD
Proteasome subunit beta type-6; part of the inp gene cluster that mediates the biosynthesis of fellutamide B, a mycotoxin that acts as a proteasome inhibitor . In the first step of fellutabmide B biosynthesis inpC activates 3-hydroxydodecanoic acid to generate 3-hydroxydodecanoyl-AMP that is then loaded onto the T0 domain of inpB . The 3-hydroxydodecanoyl-S-phosphopantetheinyl-T0 is sequentially extended with L-Asn and L-Gln by the two CAT modules of inpB . The linear lipodipeptide from inpB is then transferred onto inpA for the addition of the third amino acid, L-Leu . Reductive releasing of the lipotripeptide by the TE domain of inpA produces (2S)-fellutamide B . InpF might be involved in the release and transfer of the lipodipeptide from inpB to inpA . The inp cluster-encoded proteasome subunit inpE confers resistance to internally produced fellutamides . The MFS efflux transporter inpD may contribute to fellutamide resistance as well .
Q5B7I7
Q0BTX6
PYRG_GRABC
UTP--ammonia ligase
Granulibacter
MTRFVFITGGVVSSLGKGIASAALGALLQARGYSVRLRKLDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTGVHARKSDNATTGRIYSDVIARERRGDYLGATVQVIPHITDAIKDAVTRDLNQDLDFALIEIGGTVGDIESLPFLEAIRQLGNELGPSRTMFVHLTLVPYIPSAGELKTKPTQHSVKELQNVGIQPNMLLCRCDRLIPENERRKIANFCNVRQEAVVSALDVDTIYSVPIRYHEEGMDREVLRHFNLPIGGEPDLTRWREIADVVRAPDGVVKIAIVGKYITLLDSYKSLAEALVHGGIANRVKVEIDWVDSQIFEQADSVQRLEGVHGILVPGGFGERGAEGKIEAVRFAREHKVPFLGICFGMQMAVIEAARNLAGLPDASSTEFGPCEVPIVGLMTEWARGNDLERRSASGDLGGTMRLGSYPAALIEGSLARETYGGVPVVQERHRHRYEVNIHYREQLEAVGLRFSGLSPDGVLPEIVEYADHPWFVGVQYHPELKSKPFDPHPLFSGFVAAAVRQARLV
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Q0BTX6
Q2Y791
RL31_NITMU
50S ribosomal protein L31
Nitrosospira
MKPDIHPDYQEITVTCSCGSTFQTRSTMGKPLHIEVCSVCHPFYTGKQKIVDTAGRVEKFRQKYGKKVEKQPAAG
Binds the 23S rRNA.
Q2Y791
A9NB52
RNH_COXBR
Ribonuclease H
Coxiella
MAKQEQNIVYLYCDGACRGNPGPGGWGVLLRYNQHERQLHGGVANTTNNQMELTAAIEGLKSLKKPCQVVVTTDSQYLRRGITEWLPVWKRRGWRTSNKKPVKNQPLWETLEREVERHTIVWHWVKGHSGHAENEIADELANRGIDEVLKRGVQ
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
A9NB52
A2RD01
IF2_STRPG
Translation initiation factor IF-2
Streptococcus
MSKKRLHEIAKEIGKSSKEVVEHAKYLGLDVKSHASSVEEADAKKIISSFSKASKPDVTASQAVKPKEVAQPSVTVVKETGSEHVEKTQVSKPKSRNFKAEREARAKEQAARKQANGSSHRSQERRGGYRQPNNHQTNEQGDKRITHRSQGDTNDKRIERKASNVSPRHDNHQLVGDRNRSFAKENHKNGRFTNQKKQGRQEPQSKSPKIDFKARAAALKAEQNAEYSRQSETRFRAQQEAKRLAELARQEAKEAALKAQAEEMSHREAALKSIEEAETKLKSSNISAKSTADNRRKKQARPEKNRELTHHSQEGQKKNKKSWNSQNQVRNQKNSNWNKNKKTKKGKNVKNTNTAPKPVTERKFHELPKEFEYTEGMTVAEIAKRIKREPAEIVKKLFMMGVMATQNQSLDGDTIELLMVDYGIEAKAKVEVDDADIERFFEDENYLNPENIVERAPVVTIMGHVDHGKTTLLDTLRNSRVATGEAGGITQHIGAYQIEEAGKKITFLDTPGHAAFTSMRARGASVTDITILIVAADDGVMPQTIEAINHSKAAGVPIIVAINKIDKPGANPERVIAELAEYGIISTAWGGECEFVEISAKFNKNIDELLETVLLVAEVEELKADPTVRAIGTVIEARLDKGKGAIATLLVQQGTLHVQDPIVVGNTFGRVRAMVNDLGRRVKSAEPSTPVSITGLNETPMAGDHFAVYADEKAARAAGEERSKRALLKQRQNTQRVSLDNLFDTLKAGEIKTVNVIIKADVQGSVEALAASLVKIEVEGVRVNVVHSAVGAINESDVTLAEASNAVIIGFNVRPTPQARQQADTDDVEIRLHSIIYKVIEEVEEAMKGKLDPVYQEKVLGEAIIRETFKVSKVGTIGGFMVINGKVTRDSSVRVIRDSVVIFDGKLASLKHYKDDVKEVGNAQEGGLMIENFNDLKVDDTIEAYIMEEIVRK
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A2RD01
A3MXH2
COXX1_PYRCJ
Heme O synthase 1
Pyrobaculum
MKAYLTLLKPRVIWLLILASAAGYVYAAGGVDWGKLSSLLLAALLATGGSAAFNHYWERDIDAAMRRTSRRPLPMGLIKPGRALAFSLALSAAGVALGFLLLGPLPGAFVALGWFFYAVVYTMWLKRRSWLNVLAGGFAGNAVFLGGYALGKGHIDLAAVLMSFAVYLWIPAHIWSLAYKYKEDYRRAGVPMLPVVIGEQKAVVVISVLNVASVAYIALLTLLFLPSLLSLLLVAVGAGAAVASSIYALVKRTEGAMWKMYKSSAPVLTIFLVAVMLA
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
A3MXH2
Q2VZ23
RL25_MAGSA
General stress protein CTC
Magnetospirillum
MSEAIAIAAELRDGSGKGAARATRRAGKVPGVIYGDKKAAICIQMDPRVVWAQISKTGFFTQLFNVDLGKDGKHLCLARDVQMHPVTDQPIHVDFMRVSADHAIHVKVPVHFTNELKSPGIKKGGVLNVELHEIEITCSPNDIPHEILIDLDGLEIGASIHLSDLKLPAGAKPYHVASGATVASIAAPTVARAETTETEAAG
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
Q2VZ23
Q3ITQ5
AMZA_NATPD
Archaemetzincin
Natronomonas
MHVDIVPVGDLPAVVKREASSGLRSVYDCEVTIHDSQPVPDGAYDSGRDQYRAEEFIELASRVGNGEKNIAITDTDLYYRRRNYVFGLAYLSGKGSVISTHRLQTSSDGGFSEKSAGDIFADRVRKEVVHEVGHTLGLEHCDNSRCVMNFSPTVREVDVKEENLCGSCQRQIL
Probable zinc metalloprotease whose natural substrate is unknown.
Q3ITQ5
Q97W44
PANB_SACS2
Ketopantoate hydroxymethyltransferase
Saccharolobus
MKKVTIRDFIKKKSMKEKITMLTAYDYPTAKIISNTTLDSILVGDSLGMVVLGYTNTLNVTMRDMISHTRAVARANPPQLIVSDMPFLSYEIDVKSAVKNAGLLVKAGSDAVKLEGGEEIKDIIRAIVKAGIPVMGHIGLTPQRFLRLGGFRTIGKTKQEEEQLIKDSLELEDAGVFSIVIENTYVDIAKRITEKLNVPTICIGAGPYCDGQVLVIHDLLGLSEVTPYFAKSYVNLKEIISSAINQYIIDVKTNKFPEKQHYKERES
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Q97W44
Q3BYI0
GLGB2_XANC5
Glycogen branching enzyme 2
Xanthomonas
MSERQGGQEQRTEADGMTTEGISETSQTLQALANGLPADAFAVLGPKPLAEGRRQVRVLAPGAEAMGLIDPRGKLLARMQASAIDGVFEGILAADGPYRLRIVWPDRVQEVEDPYAFAATLDESLLLQIAAGDGQAVRRALGAQHVHCGDVPGVRFAVWAPHAQRVAVVGDFNGWDVRRHPMRQRIGGFWELFLPRVEAGARYKYAVTAADGRVLLKADPVARQTELPPATASVVPSAAAFAWTDAAWMANRDPGAVPAPLSIYEVHAASWRRDGHNQPLDWPTLAEQLIPYVQQLGFTHIELLPITEHPFGGSWGYQPLGLYAPTARHGSPDGFAQFVDACHRAGIGVILDWVSAHFPDDAHGLAQFDGAALYEHADPREGMHRDWNTLIYNYGRPEVTAYLLGSALEWIEHYHLDGLRVDAVASMLYRDYGRAEGEWVPNAHGGRENLEAVAFLRQLNREIATQFPGVLTIAEESTAWPGVTAAISDGGLGFTHKWNMGWMHDTLGYMQRDPAERAQHHSQLTFGLVYAFDERFVLPLSHDEVVHGTGGLLGQMPGDDWRRFANLRAYLALMWAHPGDKLLFMGAEFGQWADWNHDQSLDWHLLDGARHRGMQQLVGDLNAALRRTPALYRGSHRADGFDWSVADDARNSVLAFVRHDPAGGAPLLAVSNLTPQPHHDYHVGVPRAGLWREILNTDSAHYGGSNLGNSGRLATEPVGMHGHAQRLRLTLPPLATIYLQAEK
Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.
Q3BYI0
Q5RF02
TCPE_PONAB
CCT-epsilon
Pongo
MASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSMMDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAKTTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPRMPKKVEDAKIAILTCPFEPPKPKTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTAEKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAETSCALAVSQEADKCPTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKIDDIRKPGESEE
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Q5RF02
Q43385
DOF37_ARATH
Transcription factor BBFa
Arabidopsis
MDATKWTQGFQEMINVKPMEQMISSTNNNTPQQQPTFIATNTRPNATASNGGSGGNTNNTATMETRKARPQEKVNCPRCNSTNTKFCYYNNYSLTQPRYFCKGCRRYWTEGGSLRNVPVGGSSRKNKRSSTPLASPSNPKLPDLNPPILFSSQIPNKSNKDLNLLSFPVMQDHHHHALELLRSNGVSSRGMNTFLPGQMMDSNSVLYSSLGFPTMPDYKQSNNNLSFSIDHHQGIGHNTINSNQRAQDNNDDMNGASRVLFPFSDMKELSSTTQEKSHGNNTYWNGMFSNTGGSSW
Transcription factor specifically involved in the maternal control of seed germination. Regulates transcription by binding to a 5'-AA[AG]G-3' consensus core sequence. May ensure the inactivity of a component that would be activated to trigger germination as a consequence of red light perception.
Q43385
Q68W78
RL3_RICTY
50S ribosomal protein L3
typhus group
MRTGIIAQKIGMTSVFNDKGERISLTLVKVDGCQVVGHKTLAKHGYNALVIGVKDQKISRVTKPMKQVFANAKISPKTKLKEFRISEDNFIDIASILEVDHFSVGQFVDITATTIGKGFAGSMKRHNFRGLEASHGVSISHRSHGSTGQRQDPGKVFKGKKMAGHMGCNQVTIQNLKIFAIDTNRKLIMIQGSIPGHKNSYLLVKDAIKKASITI
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Q68W78
A9BUG7
RUVA_DELAS
Holliday junction ATP-dependent DNA helicase RuvA
Delftia
MIGKLTGTLLEKNPPEVLVDCGGVGYEVQVPMSTFYNLPASGAKVSLLTHFVVREDAQLLYGFGTHSERQAFRELIKITGIGPRMALSVLSGMSVEDLAQAVTLQEVGRLVKVPGIGKKTAERLLLELKGKIGADTGAQSLFVNNDQNDIVQALMALGYSDKDAAAALKKLPPDVGVTEGIKLALKALAK
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
A9BUG7
Q0HX53
DER_SHESR
GTP-binding protein EngA
Shewanella
MIPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAFLSGYEFIVVDTGGIDGTEEGIETKMAEQSLAAIEEADVVLFMTDARAGLTAADLSIAQHLRSRQKTTFVVANKIDGIDADSACAEFWSLGLGEVYQMAAAQGRGVTNMIEYALTPYAEAMGIERQGEEEEVDERQYTEEEAEAEQKRLQDLPIKLAIIGKPNVGKSTLTNRILGEERVVVYDEPGTTRDSIYIPMERDGREYVIIDTAGVRRRSKVHEVIEKFSVIKTLKAVEDANVVLLIIDAREGVAEQDLGLLGFALNAGRALVIAVNKWDGIDQGIKDRVKSELDRRLGFIDFARIHFISALHGTGVGHLFESIEEAYDSATRRVSTSMLTRIMQMSQDDHQPPLVNGRRVKLKYAHAGGYNPPIVVIHGNQVSKLPDSYKRYMMNYFRRSLKVVGTPIQLRFQEGDNPFENKVEKLTMSQERRRKRALSHIKDRKTK
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Q0HX53
A3MBD3
GCH4_BURM7
GTP cyclohydrolase FolE2
pseudomallei group
MNLMNPEFAMPDVQSTVDTRQMPIQRVGVRAVRHPLTVRTAEGETQATVGTWNLDVHLPADQKGTHMSRFVALLEERGGPLTADAFRTMLATMLEKLEARAGRIEVSFPYFVNKTAPVSGVRSLLDYEVTLTGDVRDGLTRVFAKVLVPVTSLCPCSKKISQYGAHNQRSHVTIDAELAADVPVEDLIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVARRLDADERIVAYVLEAENFESIHNHSAYALIERDKRRGA
Converts GTP to 7,8-dihydroneopterin triphosphate.
A3MBD3
Q9W2E1
STUM_DROME
Protein stum
Sophophora
MQQTLSYSSSSPSPSPMPMPSASAAQTPPPNPNLTPNLNIRPSTNPIPRPRSTGGESAFQPAIIPVDYSYRTHTTRSILSAQSMAPSTFASNQSFVRQPSESDAQPYSSLFGDPVPPPLQPDDYFGTAAFETLRNGSVELPSSEEDALVAAMALNALIPAARERIFPSVPYSRTPRGSLLPYLQPPDIQILPNSSGGSSSEQLGSPNYRLLAPDDILNKPDVYDLENEVEEYTVVGQRMSFDDEEDEPTRTPSQAPAKLSVSSITTEDHRGLLSDSYSGRDWFRPAPQHFPEFTRIPRLRPSSKMIMSMKQDEGPLSPLATMIQDMNSSSSGGEERVAPNQSRPVSRDVVLSPKQYLEEQLGLERGSQRQSLEDYRMPPPPADPPPFRRTDLTEQDDSRSVEPEHSLKREMSPVIIRDSIPMGGDYRVEQPRPHKKTAFTILSTGQAASSAPRPPQQAPTRGRHASIQSTSTTTSSPAGRPQISPRRRSIFGSEPRLPELPSALGYTSHLVHQTTDDSPRPSVQFNMSGRHSRSKLAIPQKGILQQRDSLTSSIDTFTPRAQIRRGSIGRDPIRSLPYGQKIKSMETLPLINDQHRSSIPRLHYGSTMDLSRPEPAVFPPGALPRPLKPNLNPTRRQRGLLKIINKEESLTHNPPRSNWCSLDDLSRPSFDGTPNQARRRSSSTSPERRSSTQTVSDRRSSNLSSVTATTSDFSFRRPTLSTLPAAQTLSRMRRKSVQALSPNRIPNRIPSFGQRRQSIYQRDQEPKPLSRHGKIAKPSTLSPIIGTPNKDSSSAQSPNHRSSLMADAVDTPSEVSTRRDSVSRIPVRKSPDSRSSSPPKDFGIPASGRSSRASITRSPSRTMNAGSRSPSRSMHPSRTSSRESGRPGDSRSASRGPPSRPGSRLDQIGSRMDRPNSRLERSSSRAERSSSRADRPSSRFDVSNSRGNSRANSRLSINSSSLRSSSISPATMARNRSMRATTPSRRKSISLSPASAMMGRRKSISPDAVGQNRRVSSRGKPEPPEILSRRNSRSRIPTRSTKVASKSPPSSSKKRSKSPEKPKAMGSTPKSNKVGKGVTAKGSPKAKPKIAASAKPKTKTESLMKPPVKNANKTPVNGRPTTNAKKPASKAISTKDAKVEKGKETGKSVASKSNGKETESSVKSSKSQVTKTKPPGGTTSEAKKPATTKTHGITLEKGTNGTDPVGGIPPLAAQVGNAVLQAVEAVPAVTSEVTVPSTPGGKGAGGANMSKLVRMSSRMSLLSNKSTKVRSDSPQNRKVATVQEHATEKEETVGASSQPMSNDAAAILEKSQKTLENIQKTVTEATDEIHKTISENLTDLKSLENDLAADPSPTPSSGTTMARPGESASRTGTADGSIAPQSSGELPKSPFPPTQPIEASVSVLHPNESSAERIASVPEVECESSDLPTALDASESELVGNVMPTPESGADFKVDAKRRSPDGQGGSTAGSGGLAKSSSQEFLEDKDNVKKGGLCGCCSKLFMPCRRSRCSRCCRRRERNESAEDQPVLWSGNSSATTATNVQVIDETKPKRKKISDWLKSSCCRSCRKKPAIEEHEAHQEEVSKRTNQAANMSTGPRTRGKCGLCLSKVFCCRSVNRVDPTTGDETEMKQCCFCIPCRRGSRPNKKGSTVSWRDQDPELGIKPTESSVVEGASEAAMSAATDAGNDQVKEGCCKRFWLMLLCCRKRKRRESNARRQSIRAPPPSEDTRKKLHVDLVEYSSKMKGAIPVLPLYLAWFCAFCNVVFPGLGTLLSGLFCLCVGIPRFSQFDSARARIGSFIINIIVAVSQFFCVLFCFVGWGWSIWWGTIMLRCAKKLSKIKKVERLELEEEQRQAQLAEAGKNGVAEADKT
Required for locomotion and mechanical sensing in proprioceptive neurons by transducing dendrite stretching into cellular responses. Required for transduction of mechanical stimuli in a specific subpopulation of proprioceptive neurons that sense joint angles. Probably does not constitute the mechanically activated channel and may rather serve as an accessory module required for the proper localization or function of the transduction channels.
Q9W2E1
Q5P8J4
ILVD1_AROAE
Dihydroxy-acid dehydratase 1
Aromatoleum
MSDPTRPARIDERSRNVTEGVMRAPNRSMYYAMGYRETDFGKPMVGVASAHSTITPCNSGLQPLADTVAAALKEAGANPQLFGTPTVSDGIGMGTEGMKYSLVSREVIADSIETCVNGLWQDGVVVIGGCDKNMPGGMMALVRTNVPGIYVYGGTIKPGHYKGRDLNIVSVFEAVGEFIAGQLDPVDFKEIEKRACPGSGSCGGMYTANTMSAAFEALGMSLPYSSTMANEDAEKLASAAESARVLVEAIKRGLRPRDIVTREAIENAVSVIMATGGSTNAVLHFLAIAHAAEVPWTIDDFERIRRRVPVIVDMKPSGRYLATDLHQAGGIPQVMKLLLDAGLLHGACVTITGQTIAEVLENVPAAPRADQGVIRTLSDPLYAEGHLAILRGNLSPEGCVAKISGLKNPAITGPARVFDSEDDAMAAIMARRIVEGDVVVIRYEGPKGGPGMREMLAPTSALVGQGLGESVGLITDGRFSGGTWGMVVGHVSPEAFVGGPIALVREGDSVTIDAHRQLVQLNVGDEELARRAADWTPPSPRYTRGVLAKFAKFASSASKGAVTDLDL
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
Q5P8J4
A7INB6
ENO_XANP2
2-phosphoglycerate dehydratase
Xanthobacter
MTAIVDIIGREILDSRGNPTVEVDVVLEDGALGRAAVPSGASTGAHEAVELRDGDASRYLGKGVGMAVDAVNGEIFDAIGGYEAEDQAHIDAALLALDGTPNKGRLGANAILGVSLAVAKAAAESKGLPLYRYVGGVNARVLPVPMMNIINGGAHADNPIDFQEFMILPAGAPSFAEGLRWGAEIFHTLKKGLKDAGHNTNVGDEGGFAPNLASAEAALEFVLKAIEKAGFKPGEDVYLGLDCASTEFFKNGVYNYEGEGTVRDIEAQVAYLAELVAKYPIVTIEDGMAEDDWVGWKLLTDTVGSKCQLVGDDLFVTNVERLSRGIKDGVGNSILVKVNQIGSLTETLDAVEMAHKAGYRAVMSHRSGETEDATIADLAVATNCGQIKTGSLARSDRTAKYNQLLRIEQELGDSARYAGKAALKALA
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
A7INB6
A8M8Q8
LYSZ_CALMQ
Putative [LysW]-aminoadipate/[LysW]-glutamate kinase
Caldivirga
MILVKLGGSVICGGGLDNVTNDVEPGTVLIHGGGCMVNSVMERMGVKPVILKHPNGYTSRYTDEETLKAYVMTMMLINKLIVSKLNARGIRAIGLSGVDLGLVTAKRKERVMIIDERGRTRVIDGGFSGRVTGVNVNIMNLMLSNSDVVVVSPIALSQEGLMLNVDGDQIAENIAISMNVKELVILTNVDGVLVNGKPIDKVTKANAQEILQYTTGGMRRKLETALKLTELGVRTIIANGLRDKPIRSALNGLGTVVE
Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis).
A8M8Q8
C5C5S1
SYDND_BEUC1
Non-discriminating aspartyl-tRNA synthetase
Beutenbergia
MLRTSPAGSLRAEHTAQVVTLTGWVDRRRDHGGVAFIDLRDASGIAQVVIRDEAVAHPLRNEFVLQVTGEVSRRPAGNENPNLPTGEIEVVASDVVVLNSAAALPFQVSTALADTEAIGEEVRLKYRYLDLRRPAPARAIRLRAKANQAARRVLDAEEFVEIETPTLTRSTPEGARDFLVPARLAPGSWYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQPEFTQLDVEMSFVEQDDVIALAEKVLVALWELIGFTIPTPIPRMTFDDAMRLYGTDKPDLRFGNPIVELTSYFADTPFRVFQSEYVGAVVMAGGASLPRRQFDAWQEWAKQRGARGLAYVTFPEDGSDLGGPVAKNLSDAERAGLREATGAAPGDAVFFAAGATTPSRALLGAARQEIAKRTGLIDSADQEGAWAFVWVVDAPLFKPTGDAADDGDVALGHSAWTAVHHAFTSPTPEWIDTFEQDPGSALSNAYDIVCNGNEIGGGSIRIHRRDVQERVFQVMGIDAAEAQEKFGFLLDAFSYGAPPHGGIAFGWDRILALLTGSESIREVIAFPKSGGGYDPLTQAPAPITAEQRRESGVDAVPDDETAPQA
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
C5C5S1
Q8SRW9
SC61G_ENCCU
Probable protein transport protein Sec61 subunit gamma
Encephalitozoon
MSQKLQKPSFLSEYLRSIRLFSKKCVRPSGKELSMSIKRHAIGIGFLGILGYAIKLIHIPINNIIVSSPGKE
Necessary for protein translocation in the endoplasmic reticulum.
Q8SRW9
Q890J0
GLGC_LACPL
ADP-glucose synthase
Lactiplantibacillus
MQDEMLGIILAGGQGTRLGKLTKDTAKPAVPFGGRYRIIDFTLSNCANSGVNTVGVITQYQPLELNAHIGSGASWGFDSLNGGVTVLQPYSSSEGEKFFQGTAHAIYQNIEYIDQQDPKYLLVLSGDHIYKMDYDAMLKYHQEKKASLTVGVIHVTNEEAKRFGMMNTDATDRIIEFEEKPEHPKSDKASMGIYIFNWPTLRDYLVKSYATDKSLEDFGKNVIPSYLANNESVYAYAFKGYWRDVGTIKSLWQANMEFLSPHNRLNIGDRYWRIYSKAEVLPPMFLTETSQVNNAMVVDSCYVAGEIDHSILSQRVSVGMGSRVVDSMIMPGATIGKNVVIDHALIGEDAVIGDDAQIIGTTDKIAVVGYHETMGVEQP
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
Q890J0
Q8FLJ8
TRPD_COREF
Anthranilate phosphoribosyltransferase
Corynebacterium
MTSDETLAVLIRYLDNPNPTVEEAVEVFTPMTIGEYDDVHIAALLATIRTRGETFADIAGAAKAFLNAGRPFPVPGTGVLDTAGTGGDGANTINITTGASLVAAAGGLKVVKHGNRSVSSKSGSADVLEALNIPLDLDPERAQRWFEASNFTFLFAPAYNPAIAHAQPVRKALKVPTIFNVLGPLLSPVRPEFQIMGVANPRHGQMLTEVFRELGRTRALVVHGAGTDEIAVHGTTQVWELKADGEIISYEITPEELGVERCDLTDLVGGDGVENARHMRAIFDGTGPAAHRNAVAVNAGAMFYLNSQADSLREGTAHALSLINDGTVADWLKTHEEIDYRG
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q8FLJ8
A9MFB7
IHFA_SALAR
Integration host factor subunit alpha
Salmonella
MALTKAEMSEYLFDKLGLSKRDAKELVELFFEEIRRALENGEQVKLSGFGNFDLRDKNQRPGRNPKTGEDIPITARRVVTFRPGQKLKSRVENAAPKEE
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
A9MFB7
B1AIZ3
TRUB_UREP2
tRNA-uridine isomerase
Ureaplasma
MSAISKNIIIINKPIKWTSNDVVQKVKRVIGAKKVGHAGTLDPNASGVLVLGINEGTKLLTKLILDNKSYIAEIKFGTSTNTYDAAGEIVSSTNRMVTLTEVTKIVKDFYKNDYWQKPPQFSALKINGQKAYVLARQKVDFEIAPRLVKIFKYQIMDFNYEKQILKISLHVSKGFYVRSFAVDLATKINNLAHLLTLIRTQSGPFEIKDAIEIEQVYDYWNNINKYL
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
B1AIZ3
Q4Q0R9
MTNA_LEIMA
Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
Leishmania
MMSKPHHATLESIKYTPGSLRLLDQRKLPLETVFDDVLTVEDIWSAIKEMRVRGAPAIAVSAALGIAVATQRKAANGELKSGREVQTFLLTSCDFVMTSRPTAVNLFNCLRDLKAQVDKLDPTKAAAEVAQAFVELAEAVYTNDVAFNEGIMRHGAAHILAAAKAEGRDKVSILTICNTGALATSRYGTALGVVRQLFYDGKLERVYACETRPWNQGARLTVYECVQEDIPCTLICDGAASSLMLNRKIDAVVVGADRICQNGDTANKIGTYNLAVSAKFHGVKLYVAAPTTTLDVKTASGNHVEIEEREPTEITTNLVTKQRVVADGPHLSIWNPVFDITPSELITGGIITEKGVQAPAASAPYYDIASIIAQA
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).
Q4Q0R9
P99095
GLN1A_STAAN
Glutamine synthetase I alpha
Staphylococcus
MPKRTFTKEDIRKFAEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMMFDGSSIEGFVRIEESDMYLHPDLDTWVIFPWTAGQGKVARLICDVYKTDGTPFEGDPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELNDDGGYFDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKYADAVTACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLFKGKENAFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVPGYEAPCYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAILEAGLDGIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRENEVIKKALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY
Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.
P99095
Q73ZP9
MBTK_MYCPA
Mycobactin synthase protein K
Mycobacterium avium complex (MAC)
MSDAPAESAPAQIDPAQTDPAEQPVQILPRERSDIPDAVARIPRPPVPHLDPPFALRVARLGDADMVAEWMNRPHLAAAWEYDWPTPRWRRHLGAQLQGSYSLPLIGSMRGVDLAYLELYWAAKDLISRYYDAEPYDLGLHAAIADVKLVNRGLGPMLLPRIVASVFATEPRCRRVMFDPDHRNTTARRLCEYAGCRFLGEHDTTNRRMALYALDAPTTDR
Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.
Q73ZP9
A7GSG2
RNZ_BACCN
tRNase Z
Bacillus cereus group
MEFVFLGTGAGVPSKGRNVSAIALQLLEERGGTWLFDCGEATQHQILHTSVRPRRIEKIFITHLHGDHIFGLPGLLGSRSFQGGTTPLTVYGPKGIEQFIEVALSVSTTHVKYPLEIVEITEEGIVFEDKQFYVETKRLSHGIECFGYRIVEKDIQGPLLVEKLREANVKPGPIFKRLKDGEIVELEDGRVLDGKDFIGPPQKGRIITILGDTRYCDASRILAQDADVLVHEATFAAADQTQAHDYFHSTTEQAARIALEANVKRLILTHISSRYQGDMYKELLREAKAVFAHTEIAMDLKSFPVER
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
A7GSG2
Q68WL0
RHO_RICTY
ATP-dependent helicase Rho
typhus group
MNTTNKQLTEELNNTESNNDHNDFAENNIINLKQLKRKLPEELQVQAEELKIENISSLLKQELVFAILKKSVEQGGLIVGDGVLEVLPDGFGFLRSPEVNYLAGPDDIYISPSQIRRFGLRTGDTVEGQIRAPKAGERYFALLKVNRVNFDDPVNAYHRVHFDNLTPLYPDEKLGLELENNSKDSKDFSTRVIELVAPMGKGQRALIVAPPRTGKTVLLQNIAHAITTNNPEVFLIVLLIDERPEEVTDMQRSVRGEVVSSTFDEPASRHVQLAEMVIEKAKRLVEHKKDVVILVDAITRLARAYNTVVPSSGKVLTGGVDANALQRPKRFFGAARNIENGGSLTIIGTALIETGSRMDEVIFEEFKGTGNSEIVLDRKIADKRIYPAIDITRSGTRKEDLLVDKIILNKMWVLRRIIDPMGSSEAIEFLLKKLENTKTNYEFFEMMKSPERSRNGL
Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.
Q68WL0
B1YAJ2
RNZ_PYRNV
tRNase Z
Pyrobaculum
MPLLKLVFLGTGGAVPRSDRTLPAIYLEDWLGHRFLLDAGEGAQYRLLQIGVSPASLTAVAITHQHEDHTLGLPGLVITSRFLGGRTAVLAPRSMHKALEALGVEVMDSYGGDRLRVSCVEVCHTVDACGWLFQWDVGYKLDLSKAAGLPRWALTSLIRGSPVEVGGRLIKPEDVAEPGHKRLRRLLYTGDTAPCPEMWRKVGEVDVLIHEATFADDVEPQKAHEEGHSTVADAVEAAKALNAGVLILTHVSSRYPDKRRHRELAASVKPPPHVYVPEDFDTVLVRL
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
B1YAJ2
P20457
PRI2_YEAST
DNA primase 58 kDa subunit
Saccharomyces
MFRQSKRRIASRKNFSSYDDIVKSELDVGNTNAANQIILSSSSSEEEKKLYARLYESKLSFYDLPPQGEITLEQFEIWAIDRLKILLEIESCLSRNKSIKEIETIIKPQFQKLLPFNTESLEDRKKDYYSHFILRLCFCRSKELREKFVRAETFLFKIRFNMLTSTDQTKFVQSLDLPLLQFISNEEKAELSHQLYQTVSASLQFQLNLNEEHQRKQYFQQEKFIKLPFENVIELVGNRLVFLKDGYAYLPQFQQLNLLSNEFASKLNQELIKTYQYLPRLNEDDRLLPILNHLSSGYTIADFNQQKANQFSENVDDEINAQSVWSEEISSNYPLCIKNLMEGLKKNHHLRYYGRQQLSLFLKGIGLSADEALKFWSEAFTRNGNMTMEKFNKEYRYSFRHNYGLEGNRINYKPWDCHTILSKPRPGRGDYHGCPFRDWSHERLSAELRSMKLTQAQIISVLDSCQKGEYTIACTKVFEMTHNSASADLEIGEQTHIAHPNLYFERSRQLQKKQQKLEKEKLFNNGNH
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. In a complex with DNA polymerase alpha (DNA polymerase alpha:primase) constitutes a replicative polymerase. Both primase components participate in formation of the active center, but the ATP-binding site is exclusively located on p48.
P20457
Q8PML8
LPXB_XANAC
Lipid-A-disaccharide synthase
Xanthomonas
MKGIGNRESGIVDGQRNGASVGSVTTALPIPDSPLPIPGARKRAPRIALIAGEASGDILGAGLIEQLRLRYPNAEFVGIGGDAMRGVGCQTWFDASELAVMGLTEVLRHLPRLLKLRSAFRERVLAWKPDVFIGIDAPDFNLPVERWLKQRGIKTVHYVSPSVWAWREKRAEKIGVSADLVLCLFPMEPPIYAKHGVDARFVGHPMADDIAYQSDRAAARATLGLSASSTVLAVLPGSRHGEISRLGDTFFQAAWLVSEHLPNLHVLVPAANPGCKQLLAEQLSRSSLPVMRSHLLDGQARTAMLAADVVLLASGTATLEAMLVKRPMVVGYKVAPLTYRIVKLLGLLKVNRYALPNILANDDLAPELMQDDCTPERLCVALLDWFKHPDKVAALQPRYLALHAELRRDASARAADAVAGLLSQRESGMENRESAGAGA
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Q8PML8
Q3YR20
HSLV_EHRCJ
ATP-dependent protease subunit HslV
Ehrlichia
MEHKDPSQMYGTTILCIRRGNQVIIAGDGQVSLGQTVIKNSAKKIKRLANDTVITGFAGATADAFTLFERLESKLEKHPGQLLRACVELAKDWRMDKYLRRLEAMMIVADKSISLIISGNGDVLEPENGIAAIGSGGNYALAAAKALCETNERFSQNMTLEYTITTAMRIASEICIYTNNNIIIEKIED
Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
Q3YR20
B5ZYU8
RS14_RHILW
30S ribosomal protein S14
Rhizobium
MAKTSAVEKNKRRRTTVANQAAKRAALKAIIMNQALPIEERFKASIKLASLPRDGSKTRIRNRCEVSGRPRAYYRKLRMSRIALRELGNLGKVPGIVKSSW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
B5ZYU8
Q6GM84
GFRP_XENLA
GTP cyclohydrolase I feedback regulatory protein
Xenopus
MPYVLISTQIRMETGPTIVGDEFSDLVLMAQLEADKRTVLGNNFSEYYVNEPPRVTLNKLERLGYRVVSMTGVGQTLVWCLHKE
Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1.
Q6GM84
Q9VRJ0
GEN_DROME
Xpg-like endonuclease
Sophophora
MGVKELWGVLTPHCERKPINELRGKKVAIDLAGWVCESLNVVDYFVHPRHHLKNLFFRTCYLIWEQVTPVFVLEGVAPKLKSQVIAKRNELQFRGVKPKNSPECTQSQPSKGDKGRSRFNHVLKQCETLLLSMGIQCVQGPGEAEAYCAFLNKHGLVDGVISQDSDCFAYGAVRVYRNFSVSTQGAQAAAGGAVDIYDMREITSRMDFGQQKIIVMALLCGCDYCPDGIGGIGKDGVLKLFNKYKETEILDRMRSWRGETDKYNALEIRVDDKSICSNCGHIGKTQSHTKSGCSVCRTHKGCDESLWKEQRLSIKSELTLRRKALLSPDFPNEEIIAEFLSEPDTIPNLNLNWRQPNLVKFIKQIGHLLQWPEIYCFQKFFPILTRWQVQQSKQEKILIQPHEIIKKRTVKGVPSLELRWHDPSGIFKGLIPDKQIAEYEAEHPKGIEELYYTIEPLDMLETAYPDLVAAFLKSKEKPAKKTTRKKKTASEEENKENEPNSKPKRVVRKIKAQPEENQPLLHQFLGRKKEGTPVKAPAPQRQQCSTPITKFLPSDLESDCDAEEFDMSDIVKGIISNPNAKPALTNHDGHQLHYEPMAEDLSLRLAQMSLGNVNESPKVETKRDLSQVDQLPQSKRFSLEDSFDLLVKGDLQKLARTPVERFKMQHRISEKIPTPVKPLDNISYFFNQSSDNADVFEELMNSSLVPQDQEDNAEDEEEDDLVVISD
Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA. Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the flap is double-stranded. Also possesses weak 5'- to 3'-exonuclease activity on nicked but not gapped double-stranded DNA. Does not cleave bubble-like or Holliday junction substrates.
Q9VRJ0
D1Z6B1
UTP25_SORMK
U three protein 25
Sordaria
MAFRGRGGDRGGGGRGRGGGGGFRGRGGSRGGGSRGGDRGGSRGRGRGGDRGASRGRGRGSSRGGARGGFGPRPSKFNDARLADKDEDGSEEDDISEDESNVSEEEIEGSEEEDEEGEEEAQSGQPYMSLLKSFQSATKSKKRKLDHTEEEGPNKATKTEDDDDSDDEDDDEEVKEDVDAVDEPEEDPQDAPLEDLFDEDDDLDDSDPFETHFAAPDEATFQARIKAVQANKWRTDRIAQNSNRIYYNTPETGDSTERKLPHSISGVADLKLKKKLAESMAKHTEFDEAEKAVAPLLFNYQDMLYCNRTVASSESIRRMACLHALNHVFKTRDRVIKNNTKLQRDDTLELRDQGFTRPKVLMLLPTRQSCVKMVEMICEVASPEQQEHRKRFDEGYVDKSTKFSDDKPEDFRDLFSGSDDDMFRLGMKFTRKTIKYFSQFYNSDIIFASPLGLRMAIGSEEEKKKLDYDFLSSIELVIVDQADALLMQNWEHVEFIFEHLNLQPRDAHGCDFSRVRPWYLDDQAKYFRQTVIFSAFNTPELAELQRLHCHNWAGKARLHPEYPGVIQYLGVKTRQTFSRFDAGSIAADPDARFAYFTKAIVPTLVKRAKDAAGTLIFIPSYLDFVRVRNYFANNPDVASVTFGNISEYADTPEASRARSHFLTGRHRVLLYTERAHHFRRYAIKGVKRVIFTKSEQSLMLEHGLGTVKVMFSKYDIMKLERIVGTKRAGKMITEQGDTFDFV
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
D1Z6B1
Q8VQX6
RECX_MYXXD
Regulatory protein RecX
Myxococcus
MDEARGGPDKKKERGPKRPRKVSPTYLENAALHYLKRYAATKSQLQRVLLRRVDRSIKFHGGERGEALAWVEALVAKLVRNGLLNDEAYAQMKAHSLRASGRSTRVIAQKLRLKGVPAEVVAKKVADATHEVSEEDAARIWARKKRLGPFRTQPGTREENRKRDLAALARAGFSFGIAKKVIDSNPA
Modulates RecA activity.
Q8VQX6
Q92622
RUBIC_HUMAN
Beclin-1 associated RUN domain containing protein
Homo
MRPEGAGMELGGGEERLPEESRREHWQLLGNLKTTVEGLVSTNSPNVWSKYGGLERLCRDMQSILYHGLIRDQACRRQTDYWQFVKDIRWLSPHSALHVEKFISVHENDQSSADGASERAVAELWLQHSLQYHCLSAQLRPLLGDRQYIRKFYTDAAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKHESPLLVTKSQSLTALPSSTYTPPNSYAQHSYFGSFSSLHQSVPNNGSERRSTSFPLSGPPRKPQESRGHVSPAEDQTIQAPPVSVSALARDSPLTPNEMSSSTLTSPIEASWVSSQNDSPGDASEGPEYLAIGNLDPRGRTASCQSHSSNAESSSSNLFSSSSSQKPDSAASSLGDQEGGGESQLSSVLRRSSFSEGQTLTVTSGAKKSHIRSHSDTSIASRGAPESCNDKAKLRGPLPYSGQSSEVSTPSSLYMEYEGGRYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPMYQEAEHGSFRVTSSSSQFSSRDSAQLSDSGSADEVDEFEIQDADIRRNTASSSKSFVSSQSFSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMAIPSRVLRKWDFSKYYVSNFSKDLLIKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLCHMKNMFKTCRLAKELLDSFDTVPGHLTEDLHLYSLNDLTATRKGELGPRLAELTRAGATHVERCMLCQAKGFICEFCQNEDDIIFPFELHKCRTCEECKACYHKACFKSGSCPRCERLQARREALARQSLESYLSDYEEEPAEALALEAAVLEAT
Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines . Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes .
Q92622
Q11184
LE756_CAEEL
Lethal protein 756
Caenorhabditis
MAVPAASSIVSYGGAATSNFLTTPVTPFLAGFYNSNFVTDRINSCAPYRVDRIRKQLQDEEENGYPPADDRRRGALFCRSGTWLEMLPIENPDDGSTRVKVHGTKEESSKFSIVEFVSVAMSLVSIRGVETKNFICMDPSGKLYATPSSNYSTECVFLEEMMENYYNLYASCAYGDRFNPWYIELRRSGKPRRGPNSKKRRKASHFLVVHHDLDRLRSPVPNGNDVTDLVVASLFHQPPSHPLFRQQTVTKPPNPHRISNLRAKVEMTNQAEKQRLLEEKKRRREKKKRRREDRLRKEEQIREARRQELKSLREEELRRRYQQQQQQQASTQTRYNRPQNPANPYPTYRPLPTRSTVQSPRPAYNPYWQSPVTQAPHHNSHHHHHHHPRVSSSSDPQQRHQSQQHYLAQTVSNPNRQNVNYQRYP
Required for larval development . Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development .
Q11184
Q8EK53
RL18_SHEON
50S ribosomal protein L18
Shewanella
MDKKTSRLRRAIRARKKIQELGVNRLVVHRTPRHIYAQVINPEAQVVAAASTVEKAVKEQLKSTGNVDAAKAVGKFVAERAIEKGVTNVAFDRSGFKYHGRVAALADAAREAGLQF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q8EK53
Q56226
NQO11_THET8
NDH-1 subunit 11
Thermus
MSYLLTSALLFALGVYGVLTRRTAILVFLSIELMLNAANLSLVGFARAYGLDGQVAALMVIAVAAAEVAVGLGLIVAIFRHRESTAVDDLSELRG
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient required for the synthesis of ATP.
Q56226
Q6D157
PLSY_PECAS
Lysophosphatidic acid synthase
Pectobacterium
MSVTALGMMLIAYLCGSVSSAILFCKITGLPDPRLHGSGNPGATNVLRIGGKAAAATVLVFDILKGMLPVWGAYALGVTPLYLGLTAIAACLGHIYPVFFHFRGGKGVATALGAIAPIGLDLTGLMTGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVAMLSCLILMRHHDNIQRLWRGQESKIWDKLRKKKQPEDEDTSPEE
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Q6D157
C5GDJ2
RCF1_AJEDR
Respiratory supercomplex factor 1, mitochondrial
Blastomyces
MPNIDNTPLPSSFDAHPEFFQETKWQKVTRRLKEEPLIPIGYAATSYALWRAYKSMKARDSVELNRMFRARIYGHAFTLFAIVAGGIYYGQERKQRKEFEKALQEKQDQEKRDAWLRELEVRDKEDKDWRQRHAAMEMAAKEAEKKMG
Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.
C5GDJ2
Q57K67
YGFZ_SALCH
tRNA-modifying protein YgfZ
Salmonella
MAFISFPPRHPSSSARLPLTLIALDDWALSTITGVDSEKYIQGQVTADVSQMTEQQHLLAAHCDAKGKMWSTLRLFRERDGFAWIERRSVLEAQLTELKKYAVFSKVVIAPDDERVLLGVAGFQARAALANVFSVLPNSENQVVRDGASTLLWFEHPAERFLLVTDVATANMLTEKLHGEAELNNSQQWLALDIEAGIPAIDAANSGQFIPQATNLQALGGISFKKGCYTGQEMVARAKFRGANKRALWLLAGKASRVPEAGEDLELQMGENWRRTGAILAATQLDDGQLLVQAVMNNDLEAESVFRVRDDANTLHIVPLPYSLEE
Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication.
Q57K67
Q1C5W7
MACB2_YERPA
Macrolide export ATP-binding/permease protein MacB 2
Yersinia
MTGPQQGKILLRLENVSREFITGEQTVRVLNNINLTLHSGEMVAIVGTSGSGKSTLMNILGCLDKPSAGEYWVAGRIPQYLGSDALAELRREHFGFIFQRYHLLNDLSARENVEIPAIYAGIDREERRKRAVNLLSRIGLAERLDYRPSQLSGGQQQRVSIARALMNGGDVILADEPTGALDTHSGNEVLNILKDLHQQGHTVVIVTHDMSIAEHAQRIIELKDGEIIADRPRDHAQEKPKMVDIPSVIDIPSMDEKISTGAQQETEIARKPLLTRWKVQYDRLHEAFKMAILAMAAQRLRTALTMLGIIIGIASVVSVVALGKGSQQQVLANINAMGTSTLEIFPGKDFGDMRSAAIHTLRDTDADVLAQQGYIHSVTPTVSTSVTLRYGNKSVSGTVNGVGEQYFLVRGYTIAQGMAFTRTSVNDLMQDAVIDENTRDKLFPNGETPLGKVILLGSLPCRVIGVAAKKQSGFGSDENLNVWIPYTTAMKRMLGQSYLKSITVRVNDDIDLANAEQGVIKLLSQRHGTQDFFVMNTDSIRQTIQATTSTMTLLVSMIAVISLIVGGIGVMNIMLVSVTERTKEIGVRMAVGARASDIMQQFLIEAVLVCLLGGSLGVALSLGIGLLFSLFSSNFSMVYSAASIITAFVCSSLIGVIFGFFPAKRAAEMDPIRALERE
Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
Q1C5W7
Q9SFW8
NLP5_ARATH
Nodule inception protein-like protein 5
Arabidopsis
MENNSLPMDPAMDSSFMDGLLLEGCWLETTDASEFLNFSPSTSVAPFDPSSFMWSPTQDTSNSLSQMYGQDCPERSSLEDQNQGRDLSTFNRRWWIGPSGHHGFSVMERLVQAVTHIKDFTSERGSLIQLWVPVDRGGKRVLTTKEQPFSHDPMCQRLAHYREISENYQFSTEQEDSDSSSRDLVGLPGRVFLGKVPEWTPDVRFFKNEEYPRVQHAQDCDVRGTLAIPVFEQGSQICLGVIEVVMTTQMVKLSPDLESICRALQAVDLRSTEIPIPPSLKGPDFSYQAALPEIRNLLRCACETHKLPLAQTWVSCLKQSKTGCRHNDENYIHCVSTIDDACYVGDPTVREFHEACSEHHLLKGQGVVGEAFLTNGPCFSSDVSSYKKSEYPLSHHATMFGLHGTVAIRLRCIHTGSVDFVLEFFLPKNCRDIEEQRKMLNALSTIMAHVPRSLRTVTQKELEEEGDSMVSEVIEKGVTLPKIENTTEVHQSISTPQNVGLVFDGGTTEMGELGSEYGKGVSVNENNTFSSASGFNRVTEKKRTKAEKNITLDVLRQYFAGSLKDAAKSIGVCPTTLKRICRQHGIQRWPSRKIKKVGHSLQKIQRVIDSVEGVSGHHLPIGSFYASFPNLAASPEASSLQQQSKITTFLSYSHSPPAKSPGSSCSHSSSCSSETQVIKEDPTDKTRLVSRSFKETQTTHLSPSSQEDDFLRVKVSYEEEKIRFKMRNSHRLKDLLWEIAKRFSIEDVSRYDLKYLDEDNEWVLLRCDDDVEECVDVCRSFPGQTIKLLLQLSSSYLPERSSVSGCLS
Probable transcription factor.
Q9SFW8
B8E4U3
RPIA_SHEB2
Phosphoriboisomerase A
Shewanella
MTQDEMKKAAGWAALKYVERDSIVGVGTGSTVNHFIDALATMKADIEGAVSSSEASTQKMKALGIPVYDLNSVDRLSVYVDGADEINDRMDMIKGGGAALTREKIVAAVAEKFICIVDNTKQVDILGEFPLPVEVIPMARSYVARQLVKLGGDPVYREGVVTDNGNVILDVYNLKILNPKELESQINEIVGVVTNGLFAKRGADVLLVGTPDGVKTFTAE
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
B8E4U3
Q48KN0
AROC_PSE14
5-enolpyruvylshikimate-3-phosphate phospholyase
Pseudomonas
MSGNTFGKLFTVTTAGESHGPALVAIVDGCPPGLELDLQDLQRDLDRRKPGTSRHTTQRQEADEVEILSGVFEGKTTGASIGLLIRNTDQKSKDYSAIKDLFRPAHADYTYHHKYGIRDYRGGGRSSARETAMRVAAGAIAKKYLATQGIVIRGYMSQLGPIQIPFKTWDSVEDNAFFCPDPDKVPELEAYMDQLRRDQDSVGAKITVVAEGVMPGLGEPIFDRLDAELAHALMNINAVKGVEIGAGFDCVAQRGTEHRDEMTPLGFLSNQAGGILGGISSGQPIIAHLALKPTSSITTPGRSIDTDGNAADVITKGRHDPCVGIRATPIAEAMMAIVLLDHLLRHRGQNADVSVNTPVLGQL
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Q48KN0
Q68VW6
SYS_RICTY
Seryl-tRNA(Ser/Sec) synthetase
typhus group
MLNIKWIRENQELFDEKLSQRFIEPMSSKIAMLDREKRKITSLIQEFQHARKVKSKILGNMVSKSGEEFEELQRDVNHINEKLEELEQTLDNNNELNELLNMLPNIPDEEVPYGIDESMNKLVRSYGNTNKNALNKQHFELGTKLNLMDFEQTAKISGSRFVTLKGDLAKLERALINFMVDIHTKEFDFFEISPPLLVRDSAMYNAGQLPKFSEESFITTNGYRLIPTAEVSLVNIVADTIIQREKLPMRYVAYTTCFRSEAGSSGRDTRGMIRLHQFGKVELVSITTPEESKNEHEYITNASETILKKLDLPYRVMLLCTGDMGFAAKKTYDIEVWLPGQNQYREIASCSNCGDFQARRMKARYKEFGSNETTLVHTLNASGLPIGRTIVAILENYQNNDGSITIPDVLINYMGGLKKITTYSE
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Q68VW6
C3K613
FADB_PSEFS
3-hydroxyacyl-CoA dehydrogenase
Pseudomonas
MIYEGKAITVKALESGIVELKFDLKGESVNKFNRLTLNELRQAVDTIKADASIKGVIVSSGKDVFIVGADITEFVDNFKLPDAELVAGNLEANKIFSDFEDLNVPTVAAINGIALGGGLEMCLAADFRVMSATAKIGLPEVKLGIYPGFGGTVRLPRLIGADNAIEWIAAGKENRAEDALKVGAVDAVVAPDKLAEAALNLIKGAISGEFDYKAKRQPKLEKLKLNAIEQMMSFETAKGFVAGQAGPNYPAPVEAIKTIQKAANFGRDKALEVEAAGFVKLAKTSAAQSLIGLFLNDQELKKKAKAYDEIARDVKQAAVLGAGIMGGGIAYQSASKGTPILMKDINEHGIEQGLAEAAKLLVGRVDKGRMTAAKMAEVLNGIRPTLSYGDFGHVDLVVEAVVENPKVKQAVLAEVEAQVKDDTILASNTSTISISLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSELAVATTVAYAKKMGKNPIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYLMDVVGIDTGHHGRDVMAEGFPDRMKDDRRSAIDALYEAKRLGQKNGKGFYAYEADKKGKQKKVADPSVHEVLAPVIYEQREVSDEDIINWMMIALCLETVRCLEDGIVETAAEADMGLVYGIGFPPFRGGALRYIDSIGVAEFVALADKYADLGPLYHPTAKLREMAKNGQSFFG
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
C3K613
P20966
PTFBC_ECOLI
Fructose permease IIC component
Escherichia
MKTLLIIDANLGQARAYMAKTLLGAAARKAKLEIIDNPNDAEMAIVLGDSIPNDSALNGKNVWLGDISRAVAHPELFLSEAKGHAKPYTAPVAATAPVAASGPKRVVAVTACPTGVAHTFMAAEAIETEAKKRGWWVKVETRGSVGAGNAITPEEVAAADLVIVAADIEVDLAKFAGKPMYRTSTGLALKKTAQELDKAVAEATPYEPAGKAQTATTESKKESAGAYRHLLTGVSYMLPMVVAGGLCIALSFAFGIEAFKEPGTLAAALMQIGGGSAFALMVPVLAGYIAFSIADRPGLTPGLIGGMLAVSTGSGFIGGIIAGFLAGYIAKLISTQLKLPQSMEALKPILIIPLISSLVVGLAMIYLIGKPVAGILEGLTHWLQTMGTANAVLLGAILGGMMCTDMGGPVNKAAYAFGVGLLSTQTYGPMAAIMAAGMVPPLAMGLATMVARRKFDKAQQEGGKAALVLGLCFISEGAIPFAARDPMRVLPCCIVGGALTGAISMAIGAKLMAPHGGLFVLLIPGAITPVLGYLVAIIAGTLVAGLAYAFLKRPEVDAVAKAA
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.
P20966
C3PAJ0
ACCD_BACAA
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Bacillus cereus group
MLRDLFVKKKKYAAIPSEQVRKDVPDGVMTKCPKCKKIMYTKEVLKNLKVCVNCGYHHPMNAWERLDSILDEGSFREYDKEMVSLNPLEFPNYEEKLESDRKKTELNEAVVTGEGTIDDMLVVVAVMDSRFRMGSMGSVVGEKIARAVEKAYDLQVPFIIFTASGGARMQEGILSLMQMAKTSVALKKHSNAGGLFISVMTHPTTGGVSASFASLGDYNLAEPGALIGFAGRRVIEQTVREKLPEDFQTAEFLLEHGQLDAVVHRDDMRESLRKILEVHQGGEMAVWQS
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
C3PAJ0
Q8JIR6
DMT1Y_ORYLA
Y-specific doublesex- and mab-3-related transcription factor
Oryzias
MSKEKQCRPGPRVPKCSRCRNHSLKTPLKGHKRFCRWKDCHCLKCKLIVDRQRVMAAQVALRRQQAQEEELGICSPEASSGPEVVVKNEAGADCLFSVEGRSGTPAPPPNPNPLSVAGSYSASSSSPSAAARVYSEEASDQPLETSYYNFYQPSRYSSYYGNLYNYQQYQQMPPSDGRLSGHSMPSQYRMHSFYPGTAYLPQGLGSPVPPYFSLEDNDGAAASFFPSSLTSTHDSTLTYRSISSLVNDGVKAEFESGGQPPSSRPTP
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and germ cell proliferation. Acts both as a transcription repressor and activator.
Q8JIR6
Q2NFX1
RS14Z_METST
30S ribosomal protein S14 type Z
Methanosphaera
MARKYGKAARKCSRCGDHSAIVRRYGLNLCRQCFREIAPKIGFKKYN
Binds 16S rRNA, required for the assembly of 30S particles.
Q2NFX1
Q5NZS9
PSRP_AROAE
Pyruvate, water dikinase regulatory protein
Aromatoleum
MSDTPIRTVFFISDGTGITAETLGHSLLAQFPGARFRQVRVPFVDDLDKALDCARQIRETAVTDGVRPIVFSTLVNPDPLSGLREIDALFVDLFEQFINPLEAELGQRSTHTVGRFHGIAESSDYKARIEAINFAMAHDDGVSTDGELADADVILVGVSRSGKTPTSLYLAVQFGVKAANYPLIPEDFERNKLPGELHRHRSKLFGLTIAPERLSQIRQERRPNSRYASIENCRFEIDAAQKLMRRENIQWLDSTSKSIEEISATILQAVRLNRPVY
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
Q5NZS9
A8FRE9
ASTD_SHESH
Succinylglutamic semialdehyde dehydrogenase
Shewanella
MTQFIKGQWVAGLGHAVTSKNPANNDVIWNSQTATPEQVNTAVEAAREVQFDWFMLGFEARLAIVEAYRAQLEENKAEIAETIAQETGKPQWETATEAGAMIGKIGLSVAAYNKRTGTSENDTPAGRAVLRHKPHGVVAVFGPYNFPGHLPNGHIVPALLAGNTVVFKPSELTPKVAELMLKLWEKAGLPAGVINLVQGEVETGKALASHPQIDGLFFTGSSRTGHILHQQYAGEPGKILALEMGGNNPLIIKGVKDSKAAVHDIIQSAYISSGQRCTCARRLYVEKGAEGDALLAQLTDAVKRIVVGAWNAQPQPFMGAMISETAAKGMVEAQRNLVNLGGHSLVELTHIEEGTGLVSPGLIDVSQVIELPDEEYFGPLLQVVRYTDFDEAIKLANNTRYGLSAGILADSRDDYEYFLARIRAGIVNWNKQITGASGAAPFGGVGASGNHRASAFYAADYCAYPVASVEADEVSLPANLSPGLSL
Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
A8FRE9
Q1MPK8
GPMI_LAWIP
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Lawsonia
MNVVPILLLILDGYGLAPDSTGNAAKLAFTPNIDRMLAMSGGTQIHASGRAVGLPDGYMGNSEVGHLNIGAGRVVYQQMTRIDVAIENKELDSNPILLDLFTKVKSSNGRLHLLGLLSNGGVHSHIRHLEALLSIAKEHNIQVILHPFMDGRDTGPKDGLKFMKEIVSFLTSTSSGVIGSFCGRFYAMDRDKRWERIKLAWDAIVHGVGLHVEDSVKALEQAYASGETDEFIKPRVMGNSSVNCVQDNDAVLFFNFRADRARELVSAFILPDFNGFDRGRVPHLSGIATMTMYDKEFNIPVLFNHENITKTLGEVVSALGLLQLRIAETEKYAHVTYFFSGGREEVFTGEERILVQSPRDVATYDLKPEMSVMEVTDRLLTAWNSKKFSLIVCNLANPDMVGHTGNIKASISALEAVDNCVGRIEKAVAEQHGCFILTADHGNVEEMLDKSGQPQTAHSCNPVPLIAIYDGKPLNLKESGKLGDIAPTILSIWDVSIPNEMTGNNLLSSE
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Q1MPK8
B1AJP2
RSMA_UREP2
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Ureaplasma
MNKSFIKNKLKQESFVPSKKMGQNFLLSNNIKNKIVDVANINKDDLILEIGPGWGAITEILVQKTNILIAIELDKRLYAHLKTYIKTSNFHIINNDVLCVDLDNLILDYNNTQKIQKIKVVANLPYAISSKIVLKIIQSKLINDAYIMVQKEMAERIGAKVNTRGYNAFTVLVQLFCKTKILFEVNAKEFHPQPKVQSAVIHLENLHNSVNFNIEELGKFLRICFLNKRKKLKNNLSNIYDIKIINQMFIDYNLDMNLRAENIEPKMFLKLFNYLNR
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
B1AJP2
Q6ZJJ1
APX4_ORYSJ
OsAPx4
Oryza sativa
MAAPVVDAEYLRQVDRARRHLRALISSKGCAPIMLRLAWHDAGTYDVNTKTGGANGSIRYEEEYTHGSNAGLKIAIDLLEPIKAKSPKITYADLYQLAGVVAVEVTGGPTVEFIPGRRDSSVCPREGRLPDAKKGALHLRDIFYRMGLSDKDIVALSGGHTLGRAHPERSGFEGAWTQEPLKFDNSYFLELLKGESEGLLKLPTDKALLEDPSFRRYVDLYARDEDTFFKDYAESHKKLSELGFTPRSSGPASTKSDLSTGAVLAQSAVGVAVAAAVVIVSYLYEASKKSK
Plays a key role in hydrogen peroxide removal.
Q6ZJJ1
C6DHH1
ILVD_PECCP
Dihydroxy-acid dehydratase
Pectobacterium
MPKYRSATTTHGRNMAGARALWRATGMTDNDFGKPIIAVVNSFTQFVPGHVHLRDLGKLVAEQIEASGGVAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASLRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDEQSEQVERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFLNAGKRIVGLAKRYYEQDDESVLPRNIANKAAFENAMILDIAMGGSTNTVLHLLAAAQEGEVDFTMTDIDRLSRQVPHLCKVAPSTQKYHMEDVHRAGGVIGILGELDRAGLLNREVNNVLGKTLPETLEAYDVMLTQDDSVKSMYSAGPAGIRTTQAFSQDCRWDSLDTDRQEGCIRSREFAYSQDGGLAVLYGNLAENGCIVKTAGVDEGSLVFRGPAKVYESQDDAVDAILGGKVVAGDVVVIRYEGPKGGPGMQEMLYPTTYLKSMGLGKSCALITDGRFSGGTSGLSIGHASPEAASGGTIALVQDGDIIAIDIPNRSIALVLDDNALASRRAAEEARGDQAWTPHNRERQVSFALRAYASLATSADKGAVRDKSKLGG
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
C6DHH1
Q0TLQ1
MURD_ECOL5
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Escherichia
MADYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLDKLPEAVERHTGGLNDEWLMAADLIVASPGIALAHPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDECELYVLELSSFQLETTSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAKVCVVNADDALTMPIRGADERCVSFGVNMGDYHLNHQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWVNDSKATNVGSTEAALNGLHVDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKELG
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Q0TLQ1
C4LF13
TRUA_TOLAT
tRNA-uridine isomerase I
Tolumonas
MRIALGIEYFGADYYGWQRQREVNSVQQELETALSRVANHPVEIQCAGRTDAGVNATGQVIHFDTTANRQMSAWTLGINAQLPDDIAVRWAHVVDDNFHARFSATARRYRYIIYNEPLRPGILAKGVSHYYHPLNADQMNEAGQLLLGERDFTSFRAAQCQSNTPFRNIMSLSVHRAGSYVILDIQANAFLHHMVRNIMGSLLLVGTGEKPKEWIGEILDAKDRTVSGATAKAEGLYLVDVTYPLHYGLPKPPLGPLWFNA
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
C4LF13
Q06196
H3_ENTHI
Histone H3
Entamoeba
MARTKGHIERPSNKSAKAVKNVAFKAAKKMLSKDSTKKKRAHPGAVALTEIKVLQRSTELLLRKAPFQALVREIAQVSKSDLRFQSAAISALQEAAEAYLVGLFEDTNLCAIHAKRITIMPKDMQLARRIRGERT
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q06196
P38680
MTR_NEUCR
Methyltryptophan resistance protein
Neurospora
MDSQYETKKNDPNAIMPYPESNDEHVGEVRGLGGGIMDKEPEAQEGHAKFHRLGWKRLTVVLIVEAIALGSLSLPGAFATLGMVPGVILSVGMGLICIYTAHVIGQTKLKHPEIAHYADVGRVMFGRWGYEIISFMFVLQLIFIVGSHVLTGTIMWGTITDNGNGTCSLVFGIVSAIILFLLAIPPSFAEVAILGYIDFVSICAAILITMIATGIRSSHQEGGLAAVPWSCWPKEDLSLAEGFIAVSNIVFAYSFAMCQFSFMDEMHTPSDYKKSIVALGLIEIFIYTVTGGVVYAFVGPEVQSPALLSAGPLLAKVAFGIALPVIFISGSINTVVVSRYLIERIWPNNVIRYVNTPAGWMVWLGFDFGITLIAWVIAEAIPFFSDLLAICSALFISGFSFYFPALMYFKITRNDAKSQGKKYFLDALNMLCFVIGMGILGIGTYAAIQDIMDRYDHGKVSKPYSCAPLA
Required for the transport of neutral aliphatic and aromatic amino acids via the N system.
P38680
Q5PC10
COAD_SALPA
Pantetheine-phosphate adenylyltransferase
Salmonella
MQKRAIYPGTFDPITNGHLDIVTRATQMFDHVILAIAASPGKKPMFTLNERVALAQKATAHLGNVEVVGFSDLMANFARDRQANILIRGLRAVADFEYEMQLAHMNRHLMPQLESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPDNVHQALMDKLK
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
Q5PC10
P57152
SECE_BUCAI
Protein translocase subunit SecE
Buchnera
MNKHHYNRNKHKIPEKVKWISISIFFILSFFINMCFYETQLFIRIFIISCLMLCAIGTMIYTKKGKDILLYIVMSKKEMQKIIWPKYKETLYTTFIVISVTIFISFILWSIDSVIFRLIAFIISLRF
Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.
P57152
A8AW61
SSRP_STRGC
Small protein B
Streptococcus
MAKGEGKVVAQNKKARHDYTIVDTIEAGMVLTGTEIKSVRAARINLKDGFAQIKNGEAWLSNVHIAPYEEGNIWNQEPERRRKLLLHKKQIQKLEQETKGTGMTLVPLKVYLKDGYAKLLLGLAKGKHDYDKRESIKRREQNRDIARQMKNFNTR
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.
A8AW61
Q2S905
RPOB_HAHCH
Transcriptase subunit beta
Hahella
MTYSYTEKKRIRKDFGKLPAVMDVPYLLSIQLDSYHDFLQQDVAIEDRQEVGLHAAFKSVFPIVSFSGNAALEYVSYRLGQPVFDVAECQLRGVTYAAPLRVKVRLIIYDKESSTKAIKDIKEQEVYMGEVPLMTENGTFVINGTERVIVSQLHRSPGVFFDHDKGKTHSSGKLLYSARIIPYRGSWLDFEFDPKDCVFVRIDRRRKLPATILLRALGYAADEMLEMFFENSLFEVEGGEYFLDLVPSRLRGDIAIFEIKDDEGNLIVEEGRRVTARHIRQMEKAGLKRLRVPSSYLLGKVTATNIADPSTGEVIVECNTEITDDAIEKIEKAGIKRIETLYTNDLDCGPFVSDTLRIDATRSQLEALVEIYRMMRPGEPPTKESAENLFNNLFFSEERYDLSAVGRMKFNRRLGREETEGLGVLSHSDIIDVLRTLIDIRNGKGVVDDIDHLGNRRVRSVGEMAENQFRVGLVRVERAVKERLSMAESEGLMPQDLINAKPVAAAVKEFFGSSQLSQFMDQNNPLSEVTHKRRVSALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGPNIGLINSLATYARTNTYGFLESPYRKVVDGLVTDDIEYLSAIEESDYVIAQASAAVDENGRLIDELVTVRHKNEFTVMPPEKVTLMDVSPRQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPTLKAEKPLVGTGMERYVAQDSGVCVVARRGGVVVSVDAARIVVRVSDDETEAGDAGVDIYNLTKYQRSNQNTCINQRSLVMEGDEVARGDVLADGPSVDLGELALGQNMRIAFMPWNGYNFEDSILVSERVVQEDRFTTIHIQELTCVARDTKLGPEEVTADIPNVGESALAKLDDSGIIYIGAEVEPGDILVGKVTPKGETQLTPEEKLLRAIFGEKASDVKDTSLRVSTGMRGTVIDVQVFTRDGVEKDQRAKEIEQTELNKFRKDLNDEYKIVEGATFERLRSALLGQSVIGGPGLKKGDTLTEVHFNAFEKEEWFKLNMADEQLNELLEKAEGQLQERRKSIEDRYEDKKRKLQSGDDLAPGVLKIVKVYVAVKRRIQPGDKMAGRHGNKGVISAIKPVEDMPYDEQGNPVDIVLNPLGVPSRMNVGQVLETHLGAAAKGLGDKINRMLAEQKQAAEIRKFLHEIYNGIGGRNEDLDSLSDSEVLVLAANLKKGVPMATPVFDGAKEKEIKEMLRLADMDDSGQVWLYDGRTGERFERQVTVGYMYMLKLNHLVDDKMHARSTGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVNGRTKMYKNIVDGDHRMEPGMPESFNVLVKEIRSLGIDIELEAN
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q2S905
C4Y4V1
GSM1_CLAL4
Glucose starvation modulator protein 1
Clavispora
MSIRFPEIPGTTRAPGTSLSSRGIFPTSPGVPQIPTTPNSYSALLHPHKSEAKGKHPLSFSSSMTKRLTPQEKKARRPTSRACVFCHSKHLQCSHSRPCQNCIKRNLAHECRDVVRKRAKYMSTTEVPAVSGESSSESGRATGENGSEMGNPPDPQIAYLDGVFERSSIHESLQDSPMSTPASNFNSNFLNQEYMMLGDLISKPSSPSLDVPMMYAENPSRPFISLGQSDERPKSPEFNNFDFSSLDKAQYVSPLVSHHIYQNVQDIYANKVIDFDYPSSYHSLTSFLRQRFSFTGKSLSDSEKAKKRENLLMILRLIASYRPTFISTHKALFRPFDFQFLEMSFQRCLLDYENLSRLNASPTIIWRRTGEIVSMSNDLVALLGLNISTILSKRTFILELMYDDESIVEYFRLFESVAVGNLHSTIVTRCKLIKRPSEGIETNTSMDSDYIEFCSVWTVKRDLFDLPMMVVGQFLPVLPTPDGFRTY
Transcription factor which regulates nonfermentable carbon utilization.
C4Y4V1
A0KFH9
CYAY_AERHH
Iron-sulfur cluster assembly protein CyaY
Aeromonas
MKDHEYHALTDAFFQYVEDTVDAGYPDIDCERAGGVLTLSFENKTKVIINKQEPLHQIWVATRENGFHFELQGESWIDNRFGHELKTLLSKACTTQAGEPVQFP
Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
A0KFH9
B0XQ42
ERB1_ASPFC
Eukaryotic ribosome biogenesis protein 1
Aspergillus subgen. Fumigati
MNTSKASKKRKAVTRDVEEEAGVFSGDELNTGNLDGALSDNAHDLSSDEDESDSEVELIDDFSDEEDEEEEDVLDSDEIPSDGEDSAKKKSNAAPGELGAVIDDDDDDDDDESPSEEEQLNYRIEKDANGNDRFVYDEINPDDNSDYSDVDENANTIGNIPLSFYDQYPHIGYDINGKKIMRPAKGEALDALLDSIEIPKGWTGLTDPSTGKPLELSQEELELLRKVQMNEIPEDGYNPYEPIVEWFTSQQEIMPLSAAPEPKRRFVPSKHEAKRVMKIVKAIREGRILPFKPPTEEDEEDDTIVKYDLWADEAERKDHPMHIPAPKLPPPGYEESYHPPPEYLPSRKERKTWEEADPEDRDREFLPNDFGSLRRVPGYENFVKEKFERCLDLYLAPRVRRSKLNIDPESLLPKLPSPEELKPFPTACATVFRGHKGRVRTLAVDPSGLWLASGGDDGTVRVWELLTGRQLWSVKLSEEDPVNVVRWRPGKDALILAAAAGDDIFLAVPPIVDPAMEKASLDILDAGWGYAASVPPPTPAEANKKNNPPKWMRPSSSLADSGVCAVIPLRYVAKSLSWHRRGDYFVTVCPGSSTPASVAIAIHTLSKHLTQYPFRRRIKGGGPPQAAHFHPSKPILFVANQRSIRAYDLSRQLLVKILQPGARWISSFDIHPTSSTASGGDNLIVGSYDRRLLWHDLELSQRPYKTLRYHRKAIRAVKFHPGGRYPLFADASDDGSLQIFHGSVTGDMLSNATIVPLKVLKGHKITGELGVLDVDWHPREPWCVSAGADGTCRLWM
Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
B0XQ42
O67077
FTSH_AQUAE
ATP-dependent zinc metalloprotease FtsH
Aquifex
MNALKNFFIWAIIIGAAIVAFNLFEGKREFTTKVSLNEVVKLVEEGKVSYAEVRGNTAIIQTKDGQKLEVTLPPNTNLVDKMVEKGVRVEVANPEPPGGWLVNVFLSWLPILFFIGIWIFLLRQMSGGGNVNRAFNFGKSRAKVYIEEKPKVTFKDVAGIEEVKEEVKEIIEYLKDPVKFQKLGGRPPKGVLLYGEPGVGKTLLAKAIAGEAHVPFISVSGSDFVEMFVGVGAARVRDLFETAKKHAPCIIFIDEIDAVGRARGAIPVGGGHDEREQTLNQLLVEMDGFDTSDGIIVIAATNRPDILDPALLRPGRFDRQIFIPKPDVRGRYEILKVHARNKKLAKDVDLEFVARATPGFTGADLENLLNEAALLAARKGKEEITMEEIEEALDRITMGLERKGMTISPKEKEKIAIHEAGHALMGLVSDDDDKVHKISIIPRGMALGVTQQLPIEDKHIYDKKDLYNKILVLLGGRAAEEVFFGKDGITTGAENDLQRATDLAYRMVSMWGMSDKVGPIAIRRVANPFLGGMTTAVDTSPDLLREIDEEVKRIITEQYEKAKAIVEEYKEPLKAVVKKLLEKETITCEEFVEVFKLYGIELKDKCKKEELFDKDRKSEENKELKSEEVKEEVV
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
O67077
Q2IHZ3
ACPS_ANADE
4'-phosphopantetheinyl transferase AcpS
Anaeromyxobacter
MILGLGLDVVEVARIQRILAGPPARAERFLARVFAPAERAYCDARQDRATRYAARFAAKEAAVKALGTPEGVRWLDLVVERGTGAPSLALDGVAADAARRMGVARVHLTLTHDGGVAVAAVILEGAGP
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
Q2IHZ3
Q8RHK3
SYV_FUSNN
Valyl-tRNA synthetase
Fusobacterium
MNELDKNYSPNEIEEKWYKIWEDSKYFAASLSSEKENYSIVIPPPNVTGILHMGHVLNNSIQDTLIRYNRMTGKNTLWMPGCDHAGIATQNKVERKLAEDGLKKEDIGREKFLEMTWDWKEKYGGIITKQLRKLGASLDWDRERFTMDEGLSYAVRKIFNDLYHDGLIYQGEYMVNWCPSCGTALADDEVDHEEKDGHLWQIKYPVKDSDEYIIIATSRPETMLADVAVAVHPEDERYKHLIGKTLILPLVNREIPVIADEYVDKEFGTGALKITPAHDPNDYNLGKKYNLPIINMLTPDGKIVEDYPKYAGLDRFEARKKIVEDLKAQDLFIKTEHLHHAVGQCYRCQTVIEPRVSPQWFVKMKPLAEKALEVVRNGEVKILPKRMEKIYYNWLENIRDWCISRQIWWGHRIPAWYGPDRHVFVAMDEAEAKEQAKKHYGHDVELSQEEDVLDTWFSSALWPFSTMGWPEKTKELDLFYPTNTLVTGADIIFFWVARMIMFGMYELKKIPFKNVFFHGIVRDEIGRKMSKSLGNSPDPLDLIKEYGVDAIRFSMIYNTSQGQDVHFSTDLLGMGRNFANKIWNATRFVIMNLKGFDVKSVDKTKLDYELVDKWIISRLNETAKDVKDCLEKFELDNAAKAVYEFLRGDFCDWYVEIAKIRLYNDDEDKKISKLTAQYMLWTILEQGLRLLHPFMPFITEEIWQKIKVDGDTIMLQQYPVADDSLIDVKIEKSFEYIKEVVSSLRNIRAEKGISPAKPAKVVVSTSNSEELETLEKNELFIKKLANLEELTCGTDLEAPSQSSLRVAGNSSVYMILTGLLNNEAEIKKINEQLAKLEKELEPVNRKLSDEKFTSKAPQHIIDRELRIQKEYQDKIKKLKESLKSFEE
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Q8RHK3
P47421
RS13_MYCGE
30S ribosomal protein S13
Mycoplasma
MARILGIDIPNQKRIEIALTYIFGIGLSSAKTILKKAKINPDKRVKDLSEEELVAIRNAASGYKIEGDLRREIALNIKHLTEIGSWKGIRHRKNLPVRGQRTRTNARTRKGPRKTVANKKIESK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
P47421
A4SV64
COQ7_POLAQ
2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
Polynucleobacter
MSLIDRFIAEFDTALRSVVGGAHSRRPTPGSGEISHANLDVAQRKHAAGLMRVNHVGEVCAQALYQSQKMLARNPQIQVMLEHSGQEEMDHLAWCETRLQELGSHPSYLNPFWYAGSFAIGMLAGLAGDRWSLGFVAETEKQVENHLESHLETLPQEDLRSRAIVDQMRIDEIEHGQAALHAGGVVLPDPVQKVMQAMSKVMTTAAYRI
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
A4SV64
P60527
HAD_AGRTR
L-DEX
Agrobacterium tumefaciens complex
MKHIKAIAFDLYGTLFDVHSVIDQCEKRFPGRGREVSTLWRQKQLEYTWLRSLMNRYVTFEQATEDALRYTCRHLGFALDDAACTVLCDAYLRLQAFPEVPPRLRELRNRGLQLAVLSNGSPHSIGAVVGNAGIRDEFDHLISVDPVRVYKPHDRAYGLAEEAFGLARTSILFVSSNGWDATGARYFGFPTCWINRGGNVFEEMGQTPDWDLLGIDEIVRLFDSAEGSAPSV
Catalyzes the hydrolytic dehalogenation of small (S)-2-haloalkanoic acids to yield the corresponding (R)-2-hydroxyalkanoic acids . Acts on acids of short chain lengths, C(2) to C(4), with inversion of configuration at C-2 . Active with 2-halogenated carboxylic acids and converts only the S-isomer (or L-isomer) of 2-chloropropionic acid with inversion of configuration to produce R-lactate (or D-isomer) .
P60527
Q89FW1
PRMA_BRADU
Ribosomal protein L11 methyltransferase
Bradyrhizobium
MQPSPTHRASFSIGSEAAARRVVDVLTEVFFEGDAAVAAFERPDGQWDVTLHFADAPDQAWLRELVVNSAGNEIADTLAFDTVEAKDWVKASLEDLVPVPAGRFVVHGSHDRDRVAPNKLKIEIEAALAFGTGHHGTTRGCLLLLDHVLKSSRPSNVLDLGTGTGVLAIAAAKALHRAVLASDIDPPSVRVAAENGRLNEVGHHVRVIRATGFAAPDFARAGPFDLVLANILANPLRHLASPMARHLAPGARVILSGLLTHQAPAVIAAYRARGLVPLRHLRIEGWSSLLLRKVG
Methylates ribosomal protein L11.
Q89FW1
Q7D7P7
SECBL_MYCTO
SecB-like chaperone MT2006
Mycobacterium tuberculosis complex
MTDRTDADDLDLQRVGARLAARAQIRDIRLLRTQAAVHRAPKPAQGLTYDLEFEPAVDADPATISAFVVRISCHLRIQNQAADNDVKEGDTKDETQDVATADFEFAALFDYHLQEGEDDPTEEELTAYAATTGRFALYPYIREYVYDLTGRLALPPLTLEILSRPMPVSPGAQWPATRGTP
Chaperone component of an atypical, type II toxin-antitoxin chaperone (TAC) module, probably required for antitoxin HigA1 to neutralize its cognate toxin HigB1.
Q7D7P7
Q70Y13
PSBI_AMBTC
PSII 4.8 kDa protein
Amborella
MLTLKLFVYTVVIFFVSLFIFGFLSNDPGRNPGRDE
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
Q70Y13
Q9JZ24
TRMB_NEIMB
tRNA(m7G46)-methyltransferase
Neisseria
MTDTAENQTQNNWQAGHPRSIRSFVLRQSHMTAAQQRAIDTLWDSFGIDYQATPADLDARFGSSRPKILEIGFGMGTATAEIARRLPETDFLAIDVHGPGVGNLLKLIDENHLENIRVMRHDAVEVVENMLQDGSLDGIHIFFPDPWHKKRHHKRRLIQAPFIAKLLPKLKTGGYIHLATDWEEYAQQMLEVLSSFDSLQNTAADYAPTPDYRPETKFEARGKRLGHGVWDLVFKRIG
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Q9JZ24
Q9LTT3
HMG10_ARATH
Nucleosome/chromatin assembly factor group D 10
Arabidopsis
MSTDISPPYSQTHVEPVNGYPSDNKRCDDSSVPAKYDDLVRNSALFWEKLRAFLGLTSKTLKVPTVGGNTLDLHRLFIEVTSRGGIERVVKDRKWKEVIGAFSFPTTITSASFVLRKYYLKFLFQLEHVYYLEKPVSSLQSTDEALKSLANESPNPEEGIDEPQVGYEVQGFIDGKFDSGYLVTMKLGSQELKGVLYHIPQTPSQSQQTMETPSAIVQSSQRRHRKKSKLAVVDTQKPKCHRSGYNFFFAEQYARLKPEYHGQERSITKKIGHMWSNLTESEKQVYQDKGVKDVERYRIEMLEYKSSHESGATASTVAQ
Binds preferentially DNA with A/T-rich content.
Q9LTT3
A9MHG9
FABR_SALAR
HTH-type transcriptional repressor FabR
Salmonella
MGVRAQQKEKTRRSLVEAAFSQLSAERSFASLSLREVAREAGIAPTSFYRHFRDVDELGLTMVDESGLMLRQLMRQARQRIAKGGSVIRTSVSTFMEFIGNNPNAFRLLLRERSGTSAAFRAAVAREIQHFIAELADYLELENHMPRAFTEAQAEAMVTIVFSAGAEALDVGAEQRRQLEERLVLQLRMIAKGAYYWYRREQEKIAHHSE
Represses the transcription of fabB, involved in unsaturated fatty acid (UFA) biosynthesis. By controlling UFA production, FabR directly influences the physical properties of the membrane bilayer.
A9MHG9
B9E1C8
DER_CLOK1
GTP-binding protein EngA
Clostridium
MGKPIVAIVGRPNVGKSTLFNKLAGKRISIVEDTPGVTRDRVYAQAEWLNYNFTIIDTGGIEPENNDVIISKMRRQAQVAIETANVIIFIVDGREGLTAADKEVAQMLRKSKKPIVLVVNKIDNMKQENYIYEFYNLGIGEPISISASQGLGLGDMLDKLVENFKNEGNEDEDSEYIKIAFIGKPNVGKSSLINKLLGEERVIVSDIPGTTRDAIDSYLETDEGKFLLIDTAGVRRKSKVKEEIEKYSVIRTYTAVERADVCILMLDATHDISEQDEKIIGYAHELNKAIMVVINKWDLVDKDTKTVNKYKTSIGSSLSFMSYAPYLFISAKTGQRVNRIFKMVRECYDNYCKQIKTGILNDIIGKIVMMKEPPVVGNKRLKIYYVTQIGTKPPTFVFFVNDSKCIHFSYRRYIENQLRDSFDFTGTGIKLEFRERKE
GTPase that plays an essential role in the late steps of ribosome biogenesis.
B9E1C8
P01086
IAAE_HORVU
Chloroform/methanol-soluble protein CMe
Hordeum
MAFKYQLLLSAAVMLAILVATATSFGDSCAPGDALPHNPLRACRTYVVSQICHQGPRLLTSDMKRRCCDELSAIPAYCRCEALRIIMQGVVTWQGAFEGAYFKDSPNCPRERQTSYAANLVTPQECNLGTIHGSAYCPELQPGYGVVL
Inhibits trypsin in vitro. Probably plays a protective role through inhibition of insect midgut proteases.
P01086
P0AD67
MRDA_ECO57
Penicillin-binding protein 2
Escherichia
MKLQNSFRDYTAESALFVRRALVAFLGILLLTGVLIANLYNLQIVRFTDYQTRSNENRIKLVPIAPSRGIIYDRNGIPLALNRTIYQIEMMPEKVDNVQQTLDALRSVVDLTDDDIAAFRKERARSHRFTSIPVKTNLTEVQVARFAVNQYRFPGVEVKGYKRRYYPYGSALTHVIGYVSKINDKDVERLNNDGKLANYAATHDIGKLGIERYYEDVLHGQTGYEEVEVNNRGRVIRQLKEVPPQAGHDIYLTLDLKLQQYIETLLAGSRAAVVVTDPRTGGVLALVSTPSYDPNLFVDGISSKDYSALLNDPNTPLVNRATQGVYPPASTVKPYVAVSALSAGVITRNTTLFDPGWWQLPGSEKRYRDWKKWGHGRLNVTRSLEESADTFFYQVAYDMGIDRLSEWMGKFGYGHYTGIDLAEERSGNMPTREWKQKRFKKPWYQGDTIPVGIGQGYWTATPIQMSKALMILINDGIVKVPHLLMSTAEDGKQVPWVQPHEPPVGDIHSGYWELAKDGMYGVANRPNGTAHKYFASAPYKIAAKSGTAQVFGLKANETYNAHKIAERLRDHKLMTAFAPYNNPQVAVAMILENGGAGPAVGTLMRQILDHIMLGDNNTDLPAENPAVAAAEDH
Catalyzes cross-linking of the peptidoglycan cell wall.
P0AD67
B8HX52
NDHO_CYAP4
NAD(P)H dehydrogenase I subunit O
unclassified Cyanothece
MAVKKGDLVRLVEEKFVGSVEAQASDPRLPPYVFAGQGEVVDLMGEYAQVKFPVPTPNVWLRIDQLEAVK
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
B8HX52
Q2IXP6
RS8_RHOP2
30S ribosomal protein S8
Rhodopseudomonas
MSTHDPISDLITRIRNAQMRSKSKVSTPGSRMRASVLEVLKSEGYIRGYASVEHPSGRSELEIELKYFDGEPVIREIERVSRPGRRVYASVKNLPRVNNGLGISVLSTPKGIMADHDARDANVGGEVLFTVF
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
Q2IXP6
Q9I741
VGR1A_PSEAE
T6SS spike protein VgrG1a
Pseudomonas
MQLTRLVQVDCPLGPDVLLLQRMEGREELGRLFAYELHLVSENPNLPLEQLLGKPMSLSLELPGGSRRFFHGIVARCSQVAGHGQFAGYQATLRPWPWLLTRTSDCRIFQNQSVPEIIKQVFRNLGFSDFEDALTRPYREWEYCVQYRETSFDFISRLMEQEGIYYWFRHEQKRHILVLSDAYGAHRSPGGYASVPYYPPTLGHRERDHFFDWQMAREVQPGSLTLNDYDFQRPGARLEVRSNIARPHAAADYPLYDYPGEYVQSQDGEQYARNRIEAIQAQHERVRLRGVVRGIGAGHLFRLSGYPRDDQNREYLVVGAEYRVVQELYETGSGGAGSQFESELDCIDASQSFRLLPQTPVPVVRGPQTAVVVGPKGEEIWTDQYGRVKVHFHWDRHDQSNENSSCWIRVSQAWAGKNWGSMQIPRIGQEVIVSFLEGDPDRPIITGRVYNAEQTVPYELPANATQSGMKSRSSKGGTPANFNEIRMEDKKGAEQLYIHAERNQDNLVENDASLSVGHDRNKSIGHDELARIGNNRTRAVKLNDTLLVGGAKSDSVTGTYLIEAGAQIRLVCGKSVVEFNADGTINISGSAFNLYASGNGNIDTGGRLDLNSGGASEVDAKGKGVQGTIDGQVQAMFPPPAKG
Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection . Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1 . Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity .
Q9I741
Q9Y6G9
DC1L1_HUMAN
Dynein light intermediate chain 1, cytosolic
Homo
MAAVGRVGSFGSSPPGLSSTYTGGPLGNEIASGNGGAAAGDDEDGQNLWSCILSEVSTRSRSKLPAGKNVLLLGEDGAGKTSLIRKIQGIEEYKKGRGLEYLYLNVHDEDRDDQTRCNVWILDGDLYHKGLLKFSLDAVSLKDTLVMLVVDMSKPWTALDSLQKWASVVREHVDKLKIPPEEMKQMEQKLIRDFQEYVEPGEDFPASPQRRNTASQEDKDDSVVLPLGADTLTHNLGIPVLVVCTKCDAISVLEKEHDYRDEHFDFIQSHIRKFCLQYGAALIYTSVKENKNIDLVYKYIVQKLYGFPYKIPAVVVEKDAVFIPAGWDNDKKIGILHENFQTLKAEDNFEDIITKPPVRKFVHEKEIMAEDDQVFLMKLQSLLAKQPPTAAGRPVDASPRVPGGSPRTPNRSVSSNVASVSPIPAGSKKIDPNMKAGATSEGVLANFFNSLLSKKTGSPGGPGVSGGSPAGGAGGGSSGLPPSTKKSGQKPVLDVHAELDRITRKPVTVSPTTPTSPTEGEAS
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.
Q9Y6G9