accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
A5ICS0
LOLA_LEGPC
Outer-membrane lipoprotein carrier protein
Legionella
MNKLFLILLLIFSHEVFSQTSAEVLQSKLNAIQTMTANFSQIVKAKNREVSRSSGSMALQRPGRFRWQTKDPLEQLIVADGQKMWIYDVDLEQVTVKNQEKGLGGTAALFLSGYDETLTHDFDVSEKQKGKLTVFDLKSKSAKENFQRIKLIFSQSTLIGLELYDQLGQITDVKLVQIKSNPKLPAKLFQFKPPKGVDVVKQ
Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).
A5ICS0
B8HEU5
ENO_PSECP
2-phosphoglycerate dehydratase
Pseudarthrobacter
MALIDAIHAREILDSRGNPTVEVEVLLSDGQIGRAAVPSGASTGEHEAVELRDGDKGRYLGKGVQKAVDAVIDQIAPALTGFDATDQRSIDQAMLDLDGTPNKGKLGANAILGVSLAVANAAAASADLPLYKYLGGPNAHVLPVPLMNILNGGSHADSDVDIQEFMIAPIGAETFSEGLRWGVEVYHNLKSVLKEQGLSTGLGDEGGFAPNLPSNRAALDLIQEAIKNAGYTPGKDIALALDVASSEFFKDGAYQFEGKALSASEMSAYYAELVADYPLVSIEDPLDENDWEGWKTLTDAIGDKVQLVGDDLFVTNPAILQRGIDTRTANSLLVKVNQIGSLTETLDAVSLAQRAGYTTITSHRSGETEDTTIADISVATNAGQIKTGAPARSERVAKYNQLLRIEEELDDAARYAGRSAFPRFKG
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
B8HEU5
Q39RS2
HCP_GEOMG
Prismane protein
Geobacter
MGMFCNQCEQAAKGVGCDIIGVCGKNPEVAALQDLMLYGLKGLAIYADKARELGVKEEKIDYFVLEGLFTTVTNVDFDPVQIAGKLRTCYDYKERIKALYETAYREKNGSSAPQITAGPAAWVIAGDLEGLVKQGQEHGINTHHADADIRSAIEILIYGLKGMAAYADHAYILGKKDEEVFAFFHKAMAATADPAKGLMDFVGLAMECGKLNIKVMGMLNEGHVAHYGHPVPTKVPTGTRKNKGILVSGHDLRMLEELLKQTDGKGIDVYPHGEMLPAHGYPGLKKYAHLYGNFGGAWQDQAKEFPHFPGAIIFNTNCIQRPADSYKDRLFSWGQVGWPGVKHINGWDFSEVINKALECPELADAPAKEILTGFGHNAVLGVADKVIEGVKAGAIKHFFLIGGCDGAKPGRNYYTELAEKVPQDCVILTLACGKYRFNKLEFGDIGGIPRLLDIGQCNDAYSALQIALALADAFKCGVNDLPLSMILSWYEQKAVVILLSLLHLGIKNIKIGPSLPAFVTPNVLNFLVENFNLGPITTVDADLKAALGQ
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
Q39RS2
Q9RQ55
ILVC_BUCDN
Ketol-acid reductoisomerase type II
Buchnera
MNYFNTLNFRQKINQIKKCRFMEKKEFNKKNEILKNKKIVIVGCGSQGLNQGLNMRDSGLNISYALRKNSILKKNQSWINATKNNFLVGDYESLIPNADLVINLTPDKQHSNVVKELQKLMKKDACLGYSHGFNIVEKLRNIRKDITVIMVAPKCPGTEVREEYKRGFGVGTLIAVHNENDYSNMGLEVAKAWAFSTGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQTASLVCYEKLITTQNHPGYAGKLIQFGWETITESLKHGGITLMMDRLSNSSKIRAFKLSQEIKEFSQNLFQKHMDDIISGDFSSKMIQDWKNKDQNLLNWRYKTKNTSFEQSPDYDKKILEQEYYDHGILMVAILKAGIELSFETMIQSGIMEESAYYESLHELPLIANTIARKKLYEMNMVISDTAEYGNYLFSESAYPILKEFVKNINNTDLGSALPRNSVNNIELYNVNTMIRNHPIEIIGRKLRSYMKNMKTIIVG
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
Q9RQ55
Q7U140
KDC_MYCBO
Alpha-keto-acid decarboxylase
Mycobacterium tuberculosis complex
MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRVLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEALLAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGMADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVERAIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ
Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.
Q7U140
Q28UQ8
YIDC_JANSC
Membrane protein YidC
unclassified Jannaschia
MDDQNRNLILATGLSFVVILVWFLLFPPPEMVEDPNAIPPAAETGGVETDTGIALTPPVTVADAPAGADTTAPSEVALSEAARIDIDTPAVEGSISLLGGRIDDLSLRNYFTEVDGDQIVRLLSPVGSDDPYYALYGWTPSGDLGYADVPTSDTPWELESGTILTPDSPITLAWDNGSGLIFRRTIEIDDRFMFQVTQSVENTGGAEVNLAPYGIVARHGLPSDLQNFFILHEGVVRKVDGELSELGYSDLPDLDIIAREGVPAEVMEVETNGWIGFTDKYWMTTLIPGENQSFVSVVKYVPSAEIYQTEARLPYMSIAPGETAEVTTQLFAGAKEAEAIRDYENAEPGLIASLFGAEQDASRGEIPRFIDSIDWGWFYFLTKPLFWLLHWLNGAIGNMGLAIISLTLIVKAVLFPLAYRSYVSMAKMKELQPEIEKLKESAGDDRQKLQQGMMELYKKNKVNPAGGCLPILLQIPIFFSLYKVIFVTLELRHAPFFGWLNDLSAPDSSSIINLYGLLPNPAPEPESIMALIFIGILPLLLGISMWLQQKLNPAPTDAMQAQIFAWLPWVFMFMLGSFASGLLVYWIANNTLTFTQQYLIMRSQGFKPDVFGNIRSSFKKKAKEEK
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.
Q28UQ8
Q9PBC5
HISX_XYLFA
Histidinol dehydrogenase
Xylella
MKIIDWNQLDTAAQAQTLTRPAQTIATQTREAVAALIEQVRRGGDTALRDITARLDGVDLATFEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNGYRVETAPGVVCERLVRPIARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVTRVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLAQAGVVAIDMPAGPSEVLVIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQTALALQLQQLSRAEIARQALAQSRLIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGDYCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGDCALTLARAEGLDAHANAVALRMGTVP
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Q9PBC5
Q8G1L5
UVRC_BRUSU
Excinuclease ABC subunit C
Brucella
MKRLPNNPGVYRMFNSDGDVLYVGKARNLKKRVSNYARGIGHSNRITRMIRETVTMEFVVTRTETEALLLEANLIKRSRPRFNVLMRDDKSFPYILLTGGHRAPGIFKHRGARSRKGDYFGPFASAGAVGRTINALQRAFLLRTCTDSVFETRTRPCLLYQIKRCSAPCTYEISDEDYAGLVAEAKAFLSGKSQSVKDHLAAAMQAASADLDFEHAAVYRDRLAALSHVQSHQGINPQTVEEADVFAIHQEGGMTCIQVFFFRTGQNWGNRAYFPKADSSLGPAEVLGAFLSQFYDDKPCPKLVLLSETVEEQSLITEALSTRAGHKVQVSVPQRGEKKELVQHALTNAREALGRRLAETSSQARLLQGLAETFGLPRAPRRIEVYDNSHIMGTNAVGGMIVAGPEGFVKNQYRKFNIRSTDITPGDDFGMMREVIERRFSRLVKEHGTPAGEVENPDAFPAWPDVILIDGGQGQVGAVRQILGEMGISDLVTAIGIAKGVDREAGRERFFMEGKQPFTLPPRDPVLYFIQRLRDEAHRFAIGTHRARRKKEMVRNPLDEIAGIGPTRKRALLHHFGTAKAVSRAAVEDLMQIDGISEAMARAIHDHFRDK
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q8G1L5
P85298
RHG08_HUMAN
Rho-type GTPase-activating protein 8
Homo
MAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKDGDLTMWPRLVSNSKLKRSSHLSLPKYWDYRYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAARRRL
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
P85298
Q2GI75
DNAJ_EHRCR
Chaperone protein DnaJ
Ehrlichia
MSKSDYYDLLGVSKSATPEEIKKAYRKMALKYHPDKNPGNKEAEEKFKELSEAYDVLIDQDKRAAYDKYGHNAFDSSGRGGFDFNSGFSGDFSDIFNDLFGGGFRGGRGSSRRHDSGAVGSDLRFDIEITLEDSFNGKKVPISYVTYVKCSSCSGSGSEGSAKSVQCSTCHGVGNVRTQQGFFTIERTCHVCNGEGEIIQNKCKKCSGSGRVRDEVNLLVTIPKGIESGNKIRLNGKGEAGYRGARSGDLYVYSNIQKHKFFTRNGSDLYCNVPIKMTLAALGGHIEMPSIDGTWTKVKVPEGSQNGDKLRLKEKGMPIINSSKRGDMYIQITVETPVKLTKKQKELLQKFDDEPNVDCNPQSTGFFQKVKSFWKDIRSN
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Q2GI75
Q8KPQ7
KGUA_SYNE7
GMP kinase
Synechococcus
MSIGRVVVLTGPSGVGKGTLLKAILSQHPEAFLSISATTRSPRPGEVDGQHYYFLSREEFQTKIAEQEFLEWAEFAGNLYGTPRSPVIEQVNLGRTVILEIELEGARQVRKTLPSARQVMLLPPSVEELERRIRERATEDEAAIARRLLQAQTEIGAAKEFDRCVINDQLDTAITALEAAIFS
(Microbial infection) Catalyzes the phosphorylation of dZMP to dZDP, when the bacterium is infected by a phage that produces the substrate for the synthesis of dZTP (2- amino-2'-deoxyadenosine 5'-triphosphate), which is then used by the phage as a DNA polymerase substrate.
Q8KPQ7
B0R636
RADB_HALS3
DNA repair and recombination protein RadB
Halobacterium
MREDDTHLPTGCGALDELLGGGVERGTVTQLYGPPAAGKTNVALTTAVTTAAAGGLAVYVDTEGLSLARFQQLLEARATDPEAASANVIVSDAHDFDEQAQAVRDTADFADRADLIVVDSVTGFYRLARGGDDTTGDALRQVADQITHLLSLARKHDLAVVVTNQVFTDVDNDSDRARPLGGHTLAHWTGTVLRLDRFRGGTRRATLEKHRAKPDGEHAQFQITDGGIDAASADDY
Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
B0R636
Q9YGJ9
VSPH2_GLOBR
Snake venom serine protease Haly-2
Gloydius
MVLIRVLANLLILQLSYAQKSSELIIGGDECNINEHRSLVLMYYDGHQCDGTLINEEWVLTAAHCDGENMEIQLGVHSKKVPNEDVQTRVPKEKFFCDSNKTYARWNKDIMLIRLDRPVSNSAHIAPLSLPSSPPSVGSVCRIMGWGTFSTTQETYPDVPHCANINIHDFEVCQAAYPGLPATNRILCAGILEGGKDTCKGDSGGPLICNGEIQGIVSWGGHLCGNVLEPGIYTKVFDHLEWIRSIIAGNTDATCPL
Snake venom serine protease that may act in the hemostasis system of the prey.
Q9YGJ9
P38039
CYSJ_SALTY
Sulfite reductase [NADPH] flavoprotein alpha-component
Salmonella
MTTPAPLTGLLPLNPEQLARLQAATTDLTPEQLAWVSGYFWGVLNPRSGAVAVTPVPERKMPRVTLISASQTGNARRVAEALRDDLLAANLNVTLVNAGDYKFKQIASEKLLVIVTSTQGEGEPPEEAVALHKFLFSKKAPKLENTAFAVFSLGDTSYEFFCQSGKDFDSKLAELGGERLLDRVDADVEYQAAASEWRARVVDVLKSRAPVAAPSQSVATGAVNDIHTSPYTKDAPLIATLSVNQKITGRNSEKDVRHIEIDLGDSGLRYQPGDALGVWYQNDPALVKELVELLWLKGDEPVTVDGKTLPLAEALEWHFELTVNTANIVENYATLTRSESLLPLVGDKAQLQHYAATTPIVDMVRFSPAQLDAQALIDLLRPLTPRLYSIASAQAEVESEVHITVGVVRYDIEGRARAGGASSFLADRVEEEGEVRVFIEHNDNFRLPANPETPVIMIGPGTGIAPFRSFMQQRAAEGVEGKNWLFFGNPHFTEDFLYQVEWQRYVKEGVLSRIDLAWSRDQKEKIYVQDKLREQGAELWRWINDGAHIYVCGDARRMAADVEKALLEVIAEFGGMDLESADEYLSELRVERRYQRDVY
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component.
P38039
A4VYR6
RS13_STRS2
30S ribosomal protein S13
Streptococcus
MARIAGVDIPNDKRVVISLTYVYGIGLATSKKILAAAGISEDVRVKDLTSDQEDAIRREVDAIKVEGDLRREVNLNIKRLMEIGSYRGIRHRRGLPVRGQNTKNNARTRKGKAVAIAGKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
A4VYR6
Q8T2I8
SEPA_DICDI
Septase A
Dictyostelium
MSKKEPEEIKKNVTVGNYNLGVVIGKGGFGTVYQGLDIEDGDFVAIKQINLTKIPKDQLQGIMNEIDLLKNLNHANIVKYIKYVKTKDNLYIVLEYVENGSLSGIIKKFGKFPETLVCVYIRQVLEGLVYLHEQGVVHRDIKGANILTTKEGKIKLADFGVATKFDDTSAAAVVGTPYWMAPEIIELNGATTKSDIWSVGCTVIELLTGSPPYYDLGQMPALFRIVQDDCPPLPEGISPPLKDWLMQCFQKDPNLRISAQKLLKHKWIQASIKKKPVENGAGGVGNGTDSLGAPANIDDIAKNITDYNERINKKPSHQRKPSIHPKSPKGKVFLPPPEEEEDEWGDDFSNTPKSIKLPDKKSPLKLTNNKPSTPLKQQPTNNTPVQQQQQQQQPPPLKLAVPKQPVIENDDDWGDDFNTVSDLSKAVGSLNFNNNKKNETPKPNIKKPTFSEDEDEDDDDDGFGSGGDDEDDDFGDIPTSIKLNPKFGSNIKGNSSGSANTTNSSSTVVQQPKLTVSNNNNNNNKKLPLSPRQPSSGNVKEGINHGSTGSKSGGVIIDQWGEDGEEDNDWGDVATVNFDPKVIRKGTVNKPDLSTRLKNRIALSETALSNSFNNNGNDDEDEDIFADDFDEDDDEDFDLDKNLMKDNYARMSSEILKLMNLLTPEQPEEVISSACTQLITMFKENSEQKTLLIRRHGVIPIMEMLEVSNIQSHVLCSILKVVNQIIDNNMEIQENLCLVGGIPAIMKFSGPEYPASVRLETASFISKMCSTSTLTLQMFIACKGLPILVDFLLSPYAESKRLVWMAVDAIVNVFELQSPTPKNDFCRLFSKCGLLKTLPIVLRDSIADGEAAATYPDRIINLFIMFSAADSVVRKTMSAVEVIRPILDTLSQLMPEQLAKVLKSIKQLSMDHNTLANLQNAGAIRFMVPFLGRRTGAFVAEIHNHVLNTMFHLCRIDPERQYQAAIDGIIPHLQYFITSHSPLNQFALPIICDLAHSKKARSELWKNNGVAFYLSLLEERYWQVNALDSLAVWITDETHKVENIIATNENIKKLIQLFTNAESQSFAGILEPLLKIIQISIPVNILLGTSNFITKIIDKLGHTNPQVRLNLLKIITSLYECHPNAKKMIQEFKLIPIIQKIADTDKSVLVQKMASKLLEAFNANTVI
Serine/threonine-protein kinase involved in the spatial and temporal control system organizing cortical activities in mitotic and postmitotic cells.
Q8T2I8
Q9P6L5
SLA2_SCHPO
SLA2 protein homolog
Schizosaccharomyces
MSSFRLQSDHMQSDASLMTSVRKATSIDETAPKRKHVRSCIIFTWDHHTARPFWTAIKVQPLLANEVQTFKALITIHRVLQEGHKSALVDSQSEKGWLKTCERQYDGESSPKGYSDLIRDYVDYLLDKLSFHAQHPEFNGTFEYKEYISLRQVDDPNEGYETVYDMMNLQDHIDEFQKQLFSNFKRSNKNECRIAALVPLVQESYGIYRFLTSMLRALYSTVDAPETLEPLKHRYKSQHHRLRQFYADCSNLRYLTSLISVPRLPHDPPDLEGDDNIPDLPKRPASIAPQPTGASTIAPQPTGTSPSPPVEMNFPDTSDITPAYSEPEPIQDFWSDPTLDQQLAAQQAAQQAAQQQAELAAQQAAAQQAQLAAQQAAEMERQRMAAQQHQQALEAIQMAQAEQQRIAQEQLAQQQFQMQTQGQLAELEQQLLATRGQLEQSNVLLNQYDARVRTLENELSQAGVNLQEQIHQNDDLIESLKNQILTWKNKYEALAKLYTQLRQEHLDLLSKYKQIQLKASSAQEAIDKKEKMEREMKNKNLELADMILERDRARHELETMHRSQRDKQESTERELRLLQEKAASLERNKSSEVSNLLSRYNTEVAHLEDALHSKDRELANLGVELKSTENRYRQLLQEKEEELEIQKAAVDESLLQLSKLQLDRNDIDQAMDTQIDELLKSQLEKLDDIVDSVLATGIQRLDTSLYELDSPMHAGNQYATPEFILSTIENASNNATDFSTAFNNYFADGPNADHSEVINGVNLFSTAIYEVANNAKGLSRTTGDDQGSDRFVGLSRDLVNMAKRFLSSLFSVNTRKMDVNVKTDLVIGENIELQRYLQQLTQYSEKFLNKESENTVGLLNAPGENIEELVDNQLAETAQAIQQAILRLQNIAAKPKDDSLSPSELQVHDSLLSASIAITEAIARLIKAATASQAEIVAQGRGSSSRGAFYKKHNRWTEGLISAAKAVARATTTLIETADGVVNGTSSFEHLIVACNGVSAATAQLVAASRVKANFASKVQDHLEDAAKAVTEACKALVRQVESVALKAKEVQHEDFSSLGVHEYRRKEIEQQVQILKLENDLVAARRRLFDMRKTSYHVAEE
Required for cellular morphogenesis and polarization of the cortical cytoskeleton. Required for establishment of new polarized growth zones where it acts in actin organization. Involved plasma membrane internalization and is essential for fluid-phase endocytosis.
Q9P6L5
E8MJ15
LDH1_BIFL2
L-lactate dehydrogenase 1
Bifidobacterium
MVTMNRNKVVIVGTGQVGATAAFGIVTHGLCNELVLIDCSAAKALGEARDLDDGSEFQDRHVKVRAGDYADCKDADIVVITVGRKPPANSNRMAELGFTVGLVGEVVDNVMASGFDGVIVMVSNPVDVMAWYAWKRSGLPRTQVLGTGTALDTSRLKTIIGEETGLDPRNVGGFVMGEHGDSQFTAWSTVSLGGKPFARFLADNQDRFASVSTTEIEEKTRTRGNEIVAAKGGTNFGIASTVAGIVQTILWDERRIVPVSTLLDGEYGEHDVFLGVPTELRANGANEIVELDLSEDERAKLHHSAELVREHCEGLL
Catalyzes the conversion of lactate to pyruvate.
E8MJ15
Q9PE82
ATPD_XYLFA
F-type ATPase subunit delta
Xylella
MSQALTLARPYARAAFAIACEKGKCMQWSQALTFSAQVANNPIAAALLCHPQIDHEQAAALLSPEGADPAYVRFLEVIAEAHRLDVLLQVAGLYEKLRAEAEHVIKAKITSAIELAPNELNNIVTALKKRFDCEIEVTTGVDHSLIGGAVIDTGNVVIDGSIKSKLTRLQASLTH
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Q9PE82
Q6B929
PSBA_GRATL
Photosystem II Q(B) protein
Agarophyton tenuistipitatum
MTATLERRESASLWERFCTWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFVAAPPVDIDGIREPVAGSLLYGNNIISGAIIPSSAAIGIHFYPIWEAASLDEWLYNGGPYQLIVLHFLLGVSCYIGREWELSYRLGMRPWISVAFTAPVAAAAAVFLVYPIGQGSFSDGMPLGISGTFNFMLVFQAEHNILMHPFHQLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANNGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLGLWPVVGIWFTAMSVSTMAFNLNGFNFNQSVVDSQGRVINTWADILNRANLGMEVMHERNAHNFPLDLASSNSLPVSLVAPSVNG
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
Q6B929
Q3A526
HLDE_SYNC1
D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase
Syntrophotalea
MDRTNIENFLSRLKDLRALVIGDLMLDEYLWGRTERISPEAPVQVVDVVREDLRLGGAGNVINNLVTLGCQVHVASVLGEGHDGLLLRRRLEEKQVGIEGLQFDAKRTTSRKTRILASGQQMMRFDRESRCPIDATQEAVLAEFVSNSADRFDVILVSDYLKGVLTEDLLQSVIAVGKQKGIPVVIDPKGNDYAKYRGATLLTPNRKETEVASGISIVDEESLRLAARTLMQRIDLETLMVTRSEEGISIFFRNGEEVHLPTQAREVYDVTGAGDTVLSLVGLGLAGGLPVSEAAALANIGAGIVVGKVGTSTVNVEELHEAMAHHALEYDSKIRLRESLRDVLEVERRRGKTVVFTNGCFDLLHVGHVKYLQKARRLGDLLVLGLNSDASIRRLKGPSRPLISEQERAHILAALSCIDYVVVFDEDTPLELIDTLRPDILVKGGDYTPETVVGKDLVESYGGRVELIDLVDGRSTTNIIERILDRYEQG
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Q3A526
B9MLX4
SPEH_CALBD
S-adenosylmethionine decarboxylase alpha chain
Caldicellulosiruptor
MHALGRHIIAELYGCDKEVLNNRELIEKIMVESALKAGAEVREVAFHKFSPQGVSGVVVISESHLTIHTWPELGYAAVDVFTCGERVDPWQACNYITEMLKASHMTTTEVKRGLFEQPVKVANL
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
B9MLX4
Q74DB5
ACCA_GEOSL
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Geobacter
MAAQYYMEFEKPVVELEKKVQELAELAGTNAELAGEVTKLEKKVDRMREVIFSNLSRWQTVQVARHIERPFTLDYLNLIFTDFTELHGDRLFGDDHAIVAGLAKLDGEPVVVIGHQKGRDTKEKVYRNFGMPNPEGYRKALRIMELAERFRLPIITFVDTPGAFPGIGAEERGQAEAIARNLREMAALTVPIIVVVTGEGGSGGALAIAVGDRVLMLQYSIYAVISPEGCAAILWSDGTKGEQAAEALKLTAKDLKELEVIDEIVPEPLGGAHRDHEAMARTLHEAIARQLKELKAIPAEQLVEERYQKFRKMSRFIEG
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
Q74DB5
C5C0H6
RL6_BEUC1
50S ribosomal protein L6
Beutenbergia
MSRIGKIPVQVPSGVDVDIADRVVTVKGPKGTLTHRVPAPIVVARGDDGALVVTRPDDERTSRSLHGLTRTLLANLVTGVTQGYQKNLEIVGTGYRVTAKGSSLEFALGFSHPVTVSAPEGITFAVESPTKFSVAGIDKQQVGEVAANIRKIRKPEPYKGKGVRYAGEQVRRKVGKAGK
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
C5C0H6
Q96JF0
SIAT2_HUMAN
Sialyltransferase 2
Homo
MKPHLKQWRQRMLFGIFAWGLLFLLIFIYFTDSNPAEPVPSSLSFLETRRLLPVQGKQRAIMGAAHEPSPPGGLDARQALPRAHPAGSFHAGPGDLQKWAQSQDGFEHKEFFSSQVGRKSQSAFYPEDDDYFFAAGQPGWHSHTQGTLGFPSPGEPGPREGAFPAAQVQRRRVKKRHRRQRRSHVLEEGDDGDRLYSSMSRAFLYRLWKGNVSSKMLNPRLQKAMKDYLTANKHGVRFRGKREAGLSRAQLLCQLRSRARVRTLDGTEAPFSALGWRRLVPAVPLSQLHPRGLRSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPSHHFIDSSLYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRQRNPNQPFYILHPKFIWQLWDIIQENTKEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNMGTQGDLHRKGKVVLPGFQAVHCPAPSPVIPHS
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
Q96JF0
G5ECM9
CPI2_CAEEL
Cysele2
Caenorhabditis
MKAILVFALIAISIISVNAGMMTGGSVEQDASQKEYSDKAWKAVKGINDQASNNGPYYYAPIKVTKASTQVVAGISTKLEVLVGESNCKKGELQAHEITSSNCQIKDGGSRALYQVTIWEKPWENFEQFTVEKIRDVTADEQF
Cysteine protease inhibitor which inhibits members of the peptidase C1 family . Does not inhibit asparaginyl endopeptidase . Required for the uptake and/or processing of yolk proteins during the development of oocytes, probably by regulating the catalytic activity of cysteine proteases cpl-1 and cpz-1 . May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation .
G5ECM9
Q5M6L8
DNAA_STRT2
Chromosomal replication initiator protein DnaA
Streptococcus
MTEKEHFFWNKLLELAKEELTQATFDYYVLDTKLIKIQDNVATILLEEVKKLFWEKNMQSFILMTGFEVYNSEIKVEYVFDEALVSETKPTLANNDFSNKREQQTPDLPTLNSDLNSKYTFDNFIQGDENRWSVAASLAVADSPGATYNPLFIYGGPGLGKTHLLNAIGNKVLHDNPQARIKYITAENFINEFVLHIRLDKMDELKLKYRHLDVLLIDDIQSLAKKSTQATQEEFFNTFNVLHDNNKQIVLTSDRNPDQLNEMEERLVTRFKWGLTVNITPPDFETRVAILTNKIMDYDYHFPPETIEYLAGQFDSNVRDLEGALKDISLVANVRQLDTITVEVAAEAIRARKIDGPKLTLIPIEDIQSEVGKFYNVTVKEIKATKRTQNIVLARQVAMYLAREMTDNSLPKIGKEFGGRDHSTVLHAYNKIKNMLAQDDSLRIEIDTIKNKIK
Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
Q5M6L8
Q54SP2
FORB_DICDI
Formin-B
Dictyostelium
MFFKGKKKDKEKEKSHGNIGNVISVENKTGSQSNLHVEQNLSNEDLKIQFSQLLYELGVPEAKRVEMELWSNDKKWMLLVQNKDKIKENEEKMKQKGSLYETPQFYLSLLRENASIQKTISDLKVSLASNKLSWIDSFIGLSGFDEILKIFQTFQLKPEKNSIDFLILFDCVNIIKSILNSQSGVKSVMTTSHTFKVLVLCLDQSYPPELRNAVLQLTAALTLLPTVGHSYVLEAIENFKVSNREKVRFQTIIEGAKSVSNTQLHYEYLTSFMNLVNSIVNSPADLQVRIGLRSEFTALKLIELISNSKGVSEDLDTQINLFFECMEEDNDEVGAHYKEVNIRSPSEVSTKIDTLLQSHPALHHHFISIIKGLYTLASTQSDLGGSMWNILDESVGLILKDPSKESQLEKLQNENNNLKLQLSEIKLNNSNNNNNNNNSNNNNNDSNVSTPNINTGSPLLPPQQYQDLEQKLQLTQNEKNESQNKVKQLESEIKGLNSTLTGLQLKVTKLEADLLSVSVTTPPSDTNGTTSPPIEAPSSPSLGAPPPPPPPPPAPPVSGGGPPPPPPPPPPSSGGGPPPPPPPPSSGGPPPPPPPPGGMKKPGAPAVPNLPPKKSSVPSVKMVGLQWKKVNNNVIENSIWMNVKDYNLNDQFKQLEELFQVKKPTATTPTAPVGGASNVAVGGGSGSKSIVSTPTISILDPKRSQAIMIMLSRFKISFPDLSKAITNLDESKLNLEDAKSLLKFVPSSEEIELLKEEDPSCFGKPEQFLWELSKINRISEKLECFIFKQKLSTQIEELTPDINALLKGSMETKNNKSFHQILEIVLSLGNFINGGTPRGDIYGFKLDSLSGLLDCRSPSDSKVTLMTWLIQFLENKHPSLLEFHQEFTAIDEAKRVSIQNLRSEVASLKKGLTLLTNEVEKSEGASKTILSGFVGKSTDAVTLIEKQFNTALESFNSTVQFYGEDVKTSSPEEFFQHVSKFKNEFKRTIESIQKERENVQKLAARKKAAASGPSVPSASGSSINIAPKSGVSPITPTSKSSISISQKPPQSTQPSISVQQQQQQHHGDDDDDIPQNGTFMDQLMSKMKGGEAIRASRRASQYVFTQNGAGGVGAIDALNAALKNKK
Formins play an important role in the nucleation of actin and the formation of linear actin filaments.
Q54SP2
P38217
IMB2_YEAST
Transportin
Saccharomyces
MASTWKPAEDYVLQLATLLQNCMSPNPEIRNNAMEAMENFQLQPEFLNYLCYILIEGESDDVLKQHYSLQDLQNNRATAGMLLKNSMLGGNNLIKSNSHDLGYVKSNIIHGLYNSNNNLVSNVTGIVITTLFSTYYRQHRDDPTGLQMLYQLLELTSNGNEPSIKALSKIMEDSAQFFQLEWSGNTKPMEALLDSFFRFISNPNFSPVIRSESVKCINTVIPLQTQSFIVRLDKFLEIIFQLAQNDENDLVRAQICISFSFLLEFRPDKLVSHLDGIVQFMLHLITTVNEEKVAIEACEFLHAFATSPNIPEHILQPYVKDIVPILLSKMVYNEESIVLLEASNDDDAFLEDKDEDIKPIAPRIVKKKEAGNGEDADDNEDDDDDDDDEDGDVDTQWNLRKCSAATLDVMTNILPHQVMDIAFPFLREHLGSDRWFIREATILALGAMAEGGMKYFNDGLPALIPFLVEQLNDKWAPVRKMTCWTLSRFSPWILQDHTEFLIPVLEPIINTLMDKKKDVQEAAISSVAVFIENADSELVETLFYSQLLTSFDKCLKYYKKKNLIILYDAIGRFAEKCALDETAMQIILPPLIEKWALLSDSDKELWPLLECLSCVASSLGERFMPMAPEVYNRAFRILCHCVELEAKSHQDPTIVVPEKDFIITSLDLIDGLVQGLGAHSQDLLFPQGTKDLTILKIMLECLQDPVHEVRQSCFALLGDIVYFFNSELVIGNLEDFLKLIGTEIMHNDDSDGTPAVINAIWALGLISERIDLNTYIIDMSRIILDLFTTNTQIVDSSVMENLSVTIGKMGLTHPEVFSSGAFANDSNWNKWCLSVNALDDVEEKSSAYMGFLKIINLTSTEVTMSNDTIHKIVTGLSSNVEANVFAQEIYTFLMNHSAQISAINFTPDEISFLQQFTS
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Required for nuclear transport of NAB2, HRP1/NAB4 and TFG2. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins . The complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism . At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of the cargo. Efficient GTP-Ran-mediated substrate release requires RNA . The importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus .
P38217
P81824
VSP1_BOTJA
Snake venom serine protease
Bothrops
NSLVIVVGGRPCKINVHRSLVLLYNSSSLLCSGTLINQEWVLTAAHCDSKNFKMKLGVHSIKIRNKNERTRHPKEKFICPNRKKDDVLDKDIMLIRLNRPVSNSEHIAPLSLPSSPPSVGSVCYVMGWGKISSTKETYPDVPHCAKINILDHAVCRAAYTWWPATSTTLCAGILQGGKDTCEGDSGGPLICNGLQGIVSGGGNPCGQPRKPALYTKVFDYLPWIESIIAGTTTATCP
Snake venom serine protease that induces platelet aggregation through activation of protease-activated platelet receptors (PAR1/F2R and PAR4/F2RL3). On F2R, the cleavage occurs at Arg41-Ser42 (like thrombin cleavage), and Arg46-Asn47. In normal condition of hemostasis, the cleavage of the Arg41-Ser42 bond liberates a new N-terminus that functions as an agonist. However after envenomation, the cleavage of Arg46-Asn47 bond degrades this potential agonist. This may explain why the snake protease is less potent than thrombin in causing platelet aggregation and release reaction. On F2RL3, a thrombin-like activity has also been proven by calcium release from lung fibroblasts transfected with this receptor. Possesses amidolytic activities.
P81824
P33782
FAEH_ECOLX
K88 minor fimbrial subunit FaeH
Escherichia
MKITHHYKSLLSAIISVALFYSAAPHADILDGGEIQFNGFVTDDAPKWTWQISSPDQTWAVDTADARTENGQLVFDLSDKGPLPFLEGYLYEVAERGGPGFTPFITFSSNGRPFAVKEGSDTSVQRFRASVPVRDPETGNVSGQLSFTLNQGMAVSTGKQEEGASTPSGMSLVSGQSVTDVQSGSLPQGLKNRLSALLLMNKGFGNGMSAVDNGQVITQGVLADGRVMNLAAAYASAVSDFELRLPAEGTPARWQAGLNVTVTVQ
K88 minor fimbrial subunit, plays an essential role in the biogenesis of the K88 fimbriae. Fimbriae (also called pili), are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell. They enable bacteria to colonize the epithelium of specific host organs.
P33782
Q97NG0
G6PI_STRPN
Phosphohexose isomerase
Streptococcus
MSHIKFDYSKVLDKFVAPHEVEYMQSQVTAADELIRKGTGAGSDFLGWLDLPEKYDREEFDRILKAAEQIKSDSDVLVVIGIGGSYLGAKAAIDFLNHHFANLQTKEERKAPQILYAGNSISSTYLADLVEYVADKDFSVNVISKSGTTTEPAIAFRVFKELLVKKYGQEEANKRIYATTDRQKGAVKVEADANGWGTFVVPDDIGGRFSVLTAVGLLSIAASGADIKALMEGANAARKDYTSDKISENEAYQYAAVRNILYRKGYATEILVNYEPSLQYFSEWWKQLAGESEGKDQKGIYPTSANFSTDLHSLGQFIQEGTRIMFETVVRVDKPRKNVLIPTLEEDLDGLGYLQGKDVDFVNKKATDGVLLAHTDGDVPNMYVTLPEQDAFTLGYTIYFFELAIALSGYLNAINPFDQPGVEAYKRNMFALLGKPGFEELSKELNARL
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
Q97NG0
Q7VDB2
SYE_PROMA
Glutamyl-tRNA synthetase
Prochlorococcus
MKVRVRLAPSPTGSLHIGTARTALFNWLFAQRNKGSFLIRIEDTDKERSKDEFTSNILEGLQWLGLKWDEAPIIQSKRIHEHKEAIKSLINKGLAYRCFATEEELQTMRDAQINSGEAPRYDNRHRKLTKEQEQKFIKDGRSAVIRFRIEDEESVHWNDMVRGPIHWNSKDLGGDMVISRRAPANEIGDPLYNLVVVLDDAAMEITHVIRGEDHIANTAKQLLLYKALGFKEPSFAHTPLILNKDGRKLSKRDGVTSISDFKTMGYTSQAMTNYMTLLGWSPPEGMGEKFTLKESSSVFDFDRVNNAGAKFDWDKLQWLNSQEIHNWSNEKLLDSLIPLWTKEGWNLSSKDWGLKLVHLIKPSLILINDGIEESRVFFEEPLLKKDAIQQLEIPRAKEALKFICRKLEETPWHGKENEIAIELITSCSKSLDIKKGIIMKSLRAALLGTLQGPDLITSWGLLAMMENDQARIKRCL
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Q7VDB2
C8VJW1
HXNP_EMENI
Nicotinate catabolism cluster protein hxnP
Aspergillus subgen. Nidulantes
MGATATDIEKVPSAGTPDEPKAGETNVYVDTEAEKSFVRKVDFFVLPMLCLMYFFDCMDRSNLANAKTDGLEEDINLKGNEYSLLILLFYIPFGLFDLPWNLLIKRYSARIMLSLRRYAVTVVWGICALCQCAANNFGGLLAIRIILGVFEAGFFAGSTFYFTLFYTRNEMGFRLAVLQSFAVLASAFSGLISFGLFQINHSAVKGWQWLFIVEGAMTLIIGVIGFWWLPDTAQSAWFLTQRERDAASARLLRDTSAEIETKLELKAAFQTWSDWKFPIWAVITFSYPVAYATAMNFFPIIVARLGYSVVKTNLWTVAPNLVGAVVLLVVAKSSDIFRERSLHIIFSLTVSLVGMLILASIDVSHNKGVSYFACFLLASGAYIPTCLVHAWHNNNNTNENSRAANTGFFVGLGNIAGVLSAATFRTEYAPKYVPTLVATCACNGVCILATAFMGTWMRLENRRKDKEQGARIVAGQVETRMLADGEKSPEWRYFL
Major facilitator-type transporter, part of the hnx cluster involved in the purine degradation . The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism . The major facilitator-type transporters hxnP and hxnZ are probably involved in the uptake of nicotinate-derived metabolites, and the oxidoreductases hxnT and hxnY in the further metabolism of 6-OH nicotinic acid .
C8VJW1
Q98PZ2
RL14_MYCPU
50S ribosomal protein L14
Mycoplasmopsis
MLQELSVAKVADNSGAKEVGIIRNLGGSVKKSSNIGDVVICSVKKAIPNGIVKKGQVVKAVIVRTKYGIKRENGQHVSFDDNAVVIIKEDKSPRGTRVFGPVARELREKGYLKIVSLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
Q98PZ2
Q9LI77
GATA_ARATH
Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial
Arabidopsis
MLSTLQPPRSLSLLPLRRFQISKTIVSAASSKTIDTSVISPPQSQILTTRRSLLSGETTAVEIAKSYLSRIRLTEPQLKCFLHVSENVLKDAQEIDQRIAKGEELGPLAGVLIGVKDNICTQGMPSTAASRILEHYRPPFDATAVKKIKELGGIVVGKTNMDEFGMGSTTEASAFQVTANPWDLSRVPGGSSGGSAAAVAARQCMVSLGSDTGGSVRQPASFCGVVGLKPTYGRVSRFGLMAYASSLDVIGCFGSTVADAGMLLHAISGYDRFDSTSSKQDVPEFQSQFLSVDHFESKPLNGVKVGIIRETLEDGVDSGVRSATQEAASHLEALGCILTEVSLPSFSLGLPAYYVIASSESSSNLSRYDGVRYGNQVMAEELNKLYECSRGEGFGGEVKMRILMGTYALSAGYYDAYYKRAQQVRTLIRKDFKAALEQNDILISPAAPSAAYKIGEKKDDPLAMYAGDIMTVNVNLAGLPAMVLPCGLVEGGPSGLPVGLQMIGAAFDEEKLLKVGHIFEQTLKGSSFVPPLLANVA
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Q9LI77
Q5HKZ5
CYSH_STAEQ
Thioredoxin-dependent 5'-adenylylsulfate reductase
Staphylococcus
MSIERITYDNFQNDPFINELDINDETKGAYEILKWAYQTYENDIVYSCSFGAESMVLIDLISQIKPDAQIVFLDTDLHFQETYDLIDRVKDKYPQLRIKMKKPELTLEEQGEKYNPALWKNDPNQCCYIRKIKPLEDVLSGAVAWISGLRRAQSPTRAHTNFINKDERFKSIKVCPLIYWTEEEVWSYIRDKDLPYNELHDQNYPSIGCIPCTSPVFDSNDSRAGRWSNSSKTECGLHVTDKP
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
Q5HKZ5
B3MIF1
EIF3C_DROAN
Eukaryotic translation initiation factor 3 subunit 8
Sophophora
MSRFFANGSDSESESSEEEVQATNFNKASAFQFSDDEEEVKRVVRSTKEKRYENLTNIIKTIRNHKKIKDIPNTLSSFEDLTKAYTKALPVISKEENGITPRFYIRCLAELEDFINEVWEDREGRKNLSKNNSKSLGTLRQKVRKYIKDFEDDLSRFREAPDQESEAEDEEAAQDSDGGDAGDDSDAGIKREPAEAAPKVAKTVPAKAAPADDDDSDDSIDWDSDSETETESSDDENQYQNMRERFLKRTTEKEEKDDDKRKDKRKEQKIKIRKRPEDDEDGEWETVVKGHVVEKPKMFEKDAEIDIPLVLAKLVEIMSARGKKRTDRRLQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIFDYNQKISEPMKLEHWALLLEVMQSMLKLLLVNPDIHMSESVAEEHEELATSPFYVRGCPLAAVERLDDEFTKLLKECDPHSNDYVSRLKDEVNVVKTIELVLQYFENDGNNNERCRIYLRKIEHLYYKFDPEVLKKKRGEIPQNTQTSVDVMDRLCKFIYAKDDTDRIRTRAILAHIYHHAMHDNWFQARDLVLMSHLQDNIDAADPATRILYNRMMANLGLCAFRQENIKDAHHCLVDLMVTGKPKELLAQGLLPQRQHERSAEQEKIEKQRQMPFHMHINLELLECVYLVSAMLLEIPYIAAHEFDARRRMISKTFYQQLRSSERQSLVGPPESMREHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESDRVREMLTKFIKEESLRTYLFTYSNVYTSISIPSLAQMYELPVQKVHSIISKMIINEELMASLDDPTETVVMHRSEPSRLQALAMQFVDKVTNLVDVNEKVFDMKQGNFFQRGNMGNRGDRGYNRNQDGNWGGQLRDIKRIRGQRIQRGRKHQQQQQQQVQTIDEE
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
B3MIF1
B8DJ66
THIM_DESVM
4-methyl-5-beta-hydroxyethylthiazole kinase
Desulfovibrio
MPHTEHIWRNVDAVRRQAPLVHSITNFVVMNVTANALLAAGASPIMAHAREEMAELVNIVSSLVLNIGTLSAPWIDSMFLAGAAAHERGIPVVLDPVGAGASTLRTTTAAQLMERVRPAIVRGNGSEIMALAGAAGATRGVDSTRDAHAAADSARALSRRHHCVTVVSGPVDLVTDGDEEVLITGGHELMPRVTGMGCTATVLVAAHAAVAASPLEGAVSGMAAMSAAGSMAAERAAGPGSFAMHFIDALYALSEADIRARVRVGRP
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
B8DJ66
B1XN08
CYSH_SYNP2
PAdoPS reductase
unclassified Synechococcus
MGGMMPDLDLATVNEKLSEANAVEVVQWASQTFPEGLIMSTSFGIQSAVMLHLVTQVIPDIPVVWIDTGYLPEATYRFAEELGDRLNLNLKVYQSPLSPARMEALYGKLWEQDNIEAFNRYDYIRKVEPMQRALKELNAKAWLAGLRKGQTDHRKTLGYVAKQGKQYKIHPILTWTSKDVYEYLMAHDLPYHPYFDKGYVTVGDWHSSRPLMAGDESERDTRFRGLKQECGLHLPSTSEEAQSLDSSGL
Catalyzes the formation of sulfite from phosphoadenosine 5'-phosphosulfate (PAPS) using thioredoxin as an electron donor.
B1XN08
Q0KCT2
TPIS_CUPNH
Triose-phosphate isomerase
Cupriavidus
MRQKLVIGNWKMHGSLAANAALLEGIKAGAAKATLAVCAPFPYLAQCQALLNGSQVAWGAQDVSAEARGAFTGEVSASMVGEFGCTYVLVGHSERRTYHGETDQTVAAKALRALEFGIVPVVCVGETLAQREAGETEAVVGRQLQAVLDALTVEQLSRVVLAYEPVWAIGTGKTATSEQAQAVHAFLRGQVAARDAGVAERMAILYGGSVKPDNAAELFSMTDIDGGLIGGASLKSADFLAIGNA
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q0KCT2
Q99315
YG31B_YEAST
Integrase p58
Saccharomyces
MSFMDQIPGGGNYPKLPVECLPNFPIQPSLTFRGRNDSHKLKNFISEIMLNMSMISWPNDASRIVYCRRHLLNPAAQWANDFVQEQGILEITFDTFIQGLYQHFYKPPDINKIFNAITQLSEAKLGIERLNQRFRKIWDRMPPDFMTEKAAIMTYTRLLTKETYNIVRMHKPETLKDAMEEAYQTTALTERFFPGFELDADGDTIIGATTHLQEEYDSDYDSEDNLTQNGYVHTVRTRRSYNKPMSNHRNRRNNNPSREECIKNRLCFYCKKEGHRLNECRARKAVLTDLELESKDQQTPFIKTLPIVHYIAIPEMDNTAEKTIKIQNTKVKTLFDSGSPTSFIRRDIVELLKYEIYETPPLRFRGFVATKSAVTSEAVTIDLKINDLHITLAAYILDNMDYQLLIGNPILRRYPKILHTVLNTRESPDSLKPKTYRSETVNNVRTYSAGNRGNPRNIKLSFAPTILEATDPKSAGNRGDSRTKTLSLATTTPAAIDPLTTLDNPGSTQSTFAQFPIPEEASILEEDGKYSNVVSTIQSVEPNATDHSNKDTFCTLPVWLQQKYREIIRNDLPPRPADINNIPVKHDIEIKPGARLPRLQPYHVTEKNEQEINKIVQKLLDNKFIVPSKSPCSSPVVLVPKKDGTFRLCVDYRTLNKATISDPFPLPRIDNLLSRIGNAQIFTTLDLHSGYHQIPMEPKDRYKTAFVTPSGKYEYTVMPFGLVNAPSTFARYMADTFRDLRFVNVYLDDILIFSESPEEHWKHLDTVLERLKNENLIVKKKKCKFASEETEFLGYSIGIQKIAPLQHKCAAIRDFPTPKTVKQAQRFLGMINYYRRFIPNCSKIAQPIQLFICDKSQWTEKQDKAIDKLKDALCNSPVLVPFNNKANYRLTTDASKDGIGAVLEEVDNKNKLVGVVGYFSKSLESAQKNYPAGELELLGIIKALHHFRYMLHGKHFTLRTDHISLLSLQNKNEPARRVQRWLDDLATYDFTLEYLAGPKNVVADAISRAVYTITPETSRPIDTESWKSYYKSDPLCSAVLIHMKELTQHNVTPEDMSAFRSYQKKLELSETFRKNYSLEDEMIYYQDRLVVPIKQQNAVMRLYHDHTLFGGHFGVTVTLAKISPIYYWPKLQHSIIQYIRTCVQCQLIKSHRPRLHGLLQPLPIAEGRWLDISMDFVTGLPPTSNNLNMILVVVDRFSKRAHFIATRKTLDATQLIDLLFRYIFSYHGFPRTITSDRDVRMTADKYQELTKRLGIKSTMSSANHPQTDGQSERTIQTLNRLLRAYASTNIQNWHVYLPQIEFVYNSTPTRTLGKSPFEIDLGYLPNTPAIKSDDEVNARSFTAVELAKHLKALTIQTKEQLEHAQIEMETNNNQRRKPLLLNIGDHVLVHRDAYFKKGAYMKVQQIYVGPFRVVKKINDNAYELDLNSHKKKHRVINVQFLKKFVYRPDAYPKNKPISSTERIKRAHEVTALIGIDTTHKTYLCHMQDVDPTLSVEYSEAEFCQIPERTRRSILANFRQLYETQDNPEREEDVVSQNEICQYDNTSP
Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.
Q99315
Q96GS4
BORC6_HUMAN
Lysosome-dispersing protein
Homo
MESSRGRPGPETDLLAVAEHQALVFGGGPGRTSSEPPAGLRVSGEEETENVGGANRHPRTSPKTSSCGVVHRPEREALENEPGPQGTLSGAGSRRGAPGAEHEPSLSSRHKNPAPPEGKPSSGRDCRRGGPGGGMDVEQQEEEDNDEEAAAGSRAGRSFSSRLQDSRSLDGLSEACGGAGSSGSAESGAGGGRRATISSPLELEGTVSRHGDLTHFVANNLQLKIRLSGAPPPPPSAPARPCPAPAPTPTPAIPPIDPEVLRDLERLSRELGGRVDRLLRGLGGAVQELTALSVGCIQTYRDAVDSLGEAVDMSIKGMYTLLARCEELERALQPVQGLARQVRDIRRTLEVLEALCK
As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
Q96GS4
A5F4V7
RL31_VIBC3
50S ribosomal protein L31
Vibrio
MKAGIHPEYKAVNATCSCGNSFVFNSTLGKDTMHLDVCDKCHPFYSGKQRIVDTGGRVERFNKRFGALSAKK
Binds the 23S rRNA.
A5F4V7
A9BDG0
MURG_PROM4
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Prochlorococcus
MSCLLIAASGTGGHLFPALAVAEALPESWKVSWLGVSDRLESSLIPKKYQLSTIGVEGVQSRGIKRIVQIFKLLAATGSVICLIRRNRIQIVLTTGGYIAVPAVLAAKLTGKKVILHESNAIPGKATRLLGRLCDKVALGWPPAKKKLPGCKVTVTGTPVRKSFLMKNKLPSWAPSGPGPLIVVIGGSQGAVGLNDMVRAVLPFLLDQGCRIVHITGKNAQSKIIHTNLVEQPFSDDIPGLLQNADLVISRSGAGALSEFAVCEVPAILVPYPYAADNHQECNAIYASQFGAALIVHQHEPEGKALRNALERLLKKNLSQADTVENLLNLMRKGMAKMAVRDAHIHLMSLLKEAS
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
A9BDG0
Q6UEG2
AFLN_ASPPU
Aflatoxin biosynthesis protein N
Aspergillus
MPEFSLLAGHFGTLKKTIQGMPSDATLHSIMLKISQQFSSGIFYINMWPFSGTWMVVSTPSAASQIQKLNLTKPVILRRPLETVTGGPSMMSMHGETWKKWRALFNPGFNPGYIIGLAPNITDEVATFWLSCAKGQQGEVFPLESLTTRLTVDSICSVVLDTQLHHQIKDHPLATALQRQIDWTTFGTTFNPLKRYLTIRPLVLWYNNKVMDRIIGGEVDRACRTPPDHPSKSVISLALREYLQEQASTNSTRSLAEFKRLVAPQLRVFLFAGRNTTSSTLIYSYYLLAQHPEVLAKIRAEHEDVLGADPAEAQGRIKEDVQLLNKLPYTTAVIKETLRLFPPSASMREGRPDAEIIGEDGQRYPTVGCNVWTLTVALHHNSDYWDQVENFIPERWLVGPEDPLYPVKGAWRAFEFGPRSCIGQTLAMLELRIALAMTIRQFDITPAYDEWDSIHPATTAKEVNGHRAYQAERGAGGAHTADGFPCRVKERC
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of aflatoxins, a group of polyketide-derived furanocoumarins, and part of the most toxic and carcinogenic compounds among the known mycotoxins . The four major aflatoxins produced by A.parasiticus are aflatoxin B1 (AFB1), aflatoxin B2 (AFB2), aflatoxin G1 (AFG1) and aflatoxin G2 (AFG2) . The first step of the pathway is the conversion of acetate to norsolorinic acid (NOR) and requires the fatty acid synthase subunits aflA and aflB, as well as the PKS aflC . AflC combines a hexanoyl starter unit and 7 malonyl-CoA extender units to synthesize the precursor NOR . The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by the fungal fatty acid synthase aflA/aflB . The second step is the conversion of NOR to averantin (AVN) and requires the norsolorinic acid ketoreductase aflD, which catalyzes the dehydration of norsolorinic acid to form (1'S)-averantin . The norsolorinic acid reductases aflE and aflF may also play a role in the conversion of NOR to AVN . The cytochrome P450 monooxygenase aflG then catalyzes the hydroxylation of AVN to 5'hydroxyaverantin (HAVN) . The next step is performed by the 5'-hydroxyaverantin dehydrogenase aflH that transforms HAVN to 5'-oxoaverantin (OAVN) which is further converted to averufin (AVF) by aflK that plays a dual role in the pathway, as a 5'-oxoaverantin cyclase that mediates conversion of 5'-oxoaverantin, as well as a versicolorin B synthase in a later step in the pathway . The averufin oxidase aflI catalyzes the conversion of AVF to versiconal hemiacetal acetate (VHA) . VHA is then the substrate for the versiconal hemiacetal acetate esterase aflJ to yield versiconal (VAL) . Versicolorin B synthase aflK then converts VAL to versicolorin B (VERB) by closing the bisfuran ring of aflatoxin which is required for DNA-binding, thus giving to aflatoxin its activity as a mutagen . Then, the activity of the versicolorin B desaturase aflL leads to versicolorin A (VERA) . A branch point starts from VERB since it can also be converted to dihydrodemethylsterigmatocystin (DMDHST), probably also by aflL, VERA being a precursor for aflatoxins B1 and G1, and DMDHST for aflatoxins B2 and G2 . Next, the versicolorin reductase aflM and the cytochrome P450 monooxygenase aflN are involved in conversion of VERA to demethylsterigmatocystin (DMST) . AflX and aflY seem also involved in this step, through probable aflX-mediated epoxide ring-opening step following versicolorin A oxidation and aflY-mediated Baeyer-Villiger oxidation required for the formation of the xanthone ring . The methyltransferase aflO then leads to the modification of DMST to sterigmatocystin (ST), and of DMDHST to dihydrosterigmatocystin (DHST) . Both ST and DHST are then substrates of the O-methyltransferase aflP to yield O-methylsterigmatocystin (OMST) and dihydro-O-methylsterigmatocystin (DHOMST), respectively . Finally OMST is converted to aflatoxins B1 and G1, and DHOMST to aflatoxins B2 and G2, via the action of several enzymes including O-methylsterigmatocystin oxidoreductase aflQ, the cytochrome P450 monooxygenase aflU, but also the NADH-dependent flavin oxidoreductase nadA which is specifically required for the synthesis of AFG1 .
Q6UEG2
Q17103
MYC_ASTRU
c-myc
Asterias
ARVPDDDMNSLEDSDSMESCFAGEEEFYSSTLTPPTPSEDIWKKFELYPTPPLSPSHNPDDKESDRHPRHHQQDGDGSPSRSYQHLMDDDDLPLVNPQVPLLDLSSAPPIAALIQDCMWSSIIAEERRKLFMKSEKKHAEERATKKASTPSSGVMLPPLVPASEYGTSDCVDPSAVCPYPLSETRLDLFSSGTNTPSDSEEEIDVVTVEKKHHSVHKINTTRPYHKQSTKVRHQLHHRPISVALVGSLRGRPSTATILSIPIKKLKTEGNLEEVKQILQKSNLIRSSSGSSRGSSRGCSRNSSSRRVNQVSHPSSDSEDTEKRACHNVLERQRREDLRTSFLLLRDEVPELGTCDRAAKVVILKKATDYVSSLRDREETLRMDMATEKNRNLQLRRRLEALLAPLTL
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.
Q17103
Q6D137
RS18_PECAS
30S ribosomal protein S18
Pectobacterium
MARYFRRRKFCRFTAEGVVEIDYKDIATLKNYITESGKIVPSRITGTRAKYQRQLARAIKRARYLSLLPYTDRHQ
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Q6D137
O95264
5HT3B_HUMAN
Serotonin receptor 3B
Homo
MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.
O95264
P21894
SYAC_BOMMO
Alanyl-tRNA synthetase
Bombyx
MDTSMTGNEIRKTFIDFFIKKGHKYVHSSSTIPLDDPTLLFANAGMNQFKPIFLGSVDPNSDMAQYIRVVNTQKCIRAGGKHNDLDDVGKDVYHHTFFEMMGNWSFGDYFKKEICAWAWELLTDVFKLSRERLYVTYFEGDPSSGLEPDLECRNIWLNLGVPEAHILPGSMKDNFWEMGETGPCGPCSELHYDRIGDREAAHLVNMDDPDVLEIWNLVFIQFNRETDGSLKLLPTKHIDCGLGLERLVSVIQNKRANYDTDFFMPIFKAIENATGVRPYSGKVGVDDVDGIDMAYRVLADHARTLTIALSDGGCPDNTGRGYVLRRILRRAVRYASEKLNAKPGFFGSLVYTVVELLGDVFPEIKKDPDSIVHVINEEEVQFLKTLLRGRNLLYRTIEKLNNSKTLPGDVAWRLYDTYGFPIDLTQLMCEEKGLNVDMEGYEKSRKESQLVSQGKAAGQEDLIALDVHAISHLQDTGIPATDDSPKYNYLPSSTDKDALYTFAPCTAKIVALRKNKEFVSEISSGQECGVILDRTSFYAEQGGQIFDEGYMVKIDDETVEFTVKNVQVKGGYVLHAGKVEGILKVGDTLSLHIDTERRRLVMNNHTGTHVLNNVLRKVLGNDSDQRGSLVMPDRLRFDFTNKGPMTIKQIKDTENEIKEIIAKNKTVYANYTSLSEAKKINGLRAMFDEHYPDPVRVVSVGVPVEDLIKNPDAPTGFETSVEFCGGSHLHRTSHIGEYVIVSEEGIAKGIRRIVAVTGPEAIKAINKLSVLENEVNNVANFIKEQNESISHKEVSKKIVDLTNEISQAQISYWKKDELRNMLKNLKKQLDDKERAEKAIIITQVTEKAKELCLERKESKYIVSELKAFGNTKALDGALKQVKQFCPNSAAMFFSVDKDADKIYCLAAVPKSDVEKGLLASEWVQSVVDIIGGKGGGKAESAQASGNNPNSLNEAIQIANEYAKSKLN
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.
P21894
Q1LWB0
TXB1A_DANRE
Tax1-binding protein 1 homolog A
Danio
MSSSCNVGASAGGGGSVVMETSNFAHVIFQNVGKSFLPQAALECHYTLTPFITPHPKDWVGIFKVGWSSARDYYTFLWSPMPENYTEGSTVHRTIIFQGYYVPRSDGEFYQFCYVTHTGEIRGASTPFQFRPATPTGEELLTVEDDGNSDILVRVEEVQQECKELQKALRLLTQERDQLQEKQRQQNQELQKSLIEEKEEAQSRVRQLEQDLLKITQKAVLKETELDCLRDKLQKVISERDSLQTQLKNERDERELYKSHVRSAELENTKLSAELQMLKAVELNREVTIAQYQEELHRLRTERDTHPAETGLKEQLRQAEEQLQATRQQAAMLGSELRDASGGRDRTMTELYRVRQEAEELRAHLAEAQEECRHAQDQLDRMKNQTSQEMGRAGGGVGVASELEAELQKEVEELKLRLNMAAEHYKEKYRECQRLRRQVTKLTQQQETQQGDANRNDASTETTLELHTPDAETPSESYPAEIKTVARDVEKSRDEEGNEQEEEDEEEEECSLSVEAELACMEEKWREQCTINENLKLLLANEEKRFKTQVAEKDREVSALRESLVVVTKEKERLEKQYMREGTTRSRRLEVREPVVLRYPLPYPQDPPPLPLVPQQPAELQFGNPYLEQETRDGADGALSPEQTCRPPPLAPPPWGGPVVCSQPSRSLSPPDGLENPTEERPTGGDGEAPAVCEHQSLESNESHTSFCFDTRPDVHKQCPLCEVIFPPHFEQSSFERHVESHWRVCPVCSEQFPLDCQQQLYEKHVHTHFDGNVLNFDNFD
May have anti-apoptotic activity.
Q1LWB0
E5ASS2
FBID_MYCRK
3-phospho-D-glycerate guanylyltransferase
Mycetohabitans
MRCNGMSPVSVAQRNTGIWAVVPLKAPECAKTRLSGVLSHAARQALFFSMASHVIGTLRASPRIASLLVVTPSESTAEMARAAGAEILWGPPDEGMANACSRAMAHIAAAGGERVMFVPGDLPLLDGAAIDMLSRAPVDAIGMAPNRDGHGTNGLICRPGAIPLFFSGPSFSAHQNAARCAGIDVWIVRSREWALDVDLPADLEEFESSIKDAKRRVLCQI
Guanylyltransferase that catalyzes the activation of (2R)-3-phosphoglycerate (3PG) as 3-[(R)-glyceryl]-diphospho-5'-guanosine, via the condensation of 3PG with GTP. It is involved in the biosynthesis of a derivative of the hydride carrier cofactor coenzyme F420, 3PG-F420. Can also use (2S)-2-phospholactate (2-PL), with lower turnover, and has weak activity with phosphoenolpyruvate (PEP).
E5ASS2
Q9NUP1
BL1S4_HUMAN
Protein cappuccino homolog
Homo
MEGSFSDGGALPEGLAEEAEPQGAAWSGDSGTVSQSHSSASGPWEDEGAEDGAPGRDLPLLRRAAAGYAACLLPGAGARPEVEALDASLEDLLTRVDEFVGMLDMLRGDSSHVVSEGVPRIHAKAAEMRRIYSRIDRLEAFVRMVGGRVARMEEQVTKAEAELGTFPRAFKKLLHTMNVPSLFSKSAPSRPQQAGYEAPVLFRTEDYFPCCSERPQL
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
Q9NUP1
Q1JG69
QUEA_STRPD
Queuosine biosynthesis protein QueA
Streptococcus
MNTNDFDFELPEELIAQTPLEKRDSSKLLIIDHRQKTMVDSHFDHIIDQLNPGDALVMNNTRVLPARLYGEKPDTHGHVELLLLKNTQGDQWEVLAKPAKRLKVGSQVNFGNGHLKATIIDELEHGGRIVEFSYDGIFLEVLESLGEMPLPPYIHEKLEDAERYQTVYAKENGSAAAPTAGLHFTTDLLKKIEAKGVHLVYLTLHVGLGTFRPVSVDNLDEHDMHSEFYSLSEEAAQTLRDVKQAGGRVVAVGTTSIRTLETIGSKFQGDIQADSGWTNIFIKPGYQFKVVDAFSTNFHLPKSTLVMLVSAFAGRDFVLEAYRHAVDEKYRFFSFGDAMFVN
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Q1JG69
Q8T116
HCYX_SCUCO
Hemocyanin subunit X
Scutigera
MKYCTESLILILAVIGCISAAINFKCPKGTAEEKHQKEIYDLVQRINRPLIPQFKEPNFPTSFLIKGKDPKEFFQAIGHLPKKEVFSLFDERHWDEAMTAYEYLYEAETLDDFIDIAKILYLHLNEDMFYYVFSFAVLYRKDTRNVRLPQVHDVYPDKFLKTDIINKIKQANYQGKQHPVIDATKEFHDLRNPVSYLHYFLEDIGMNSHHYHWHVMNSALRKAYPTEGEKKFYRKGELFYHMHHQMLNRYELERLSNGLPRCPTFENWDDPIAEGYASHLAVDRTGYRYTFRPDNLHVRDLPELTKDNMRVWRDRIFDAATSCSVLRENGSFVKICRTRFYGGLNILGNLIESNLRSINRMFYGNIHCYAHVIAARVTDPDGKYGQGNGVMYDVATSARDPLFYQWHKFLDHFFYEHLTKLPTNHLFHLQNPDVSITNLEIISNGRKNEIHTFWENDIMEISKGHSFTLNSDAKVKIQHLQHEKFEIHLTVQNDKGEDTDLFVRIFLLPLEDEESHELSLEEMVRMAVDIEKRVIPAKPGSNDIVISSRSIGAPANKFFGSFEERYISEDCNFHSHCGWPNYLLVPKGSSQGTPFAFVVMLTLAEDDFTPNMDDTCFCADSWSHCGSLFIQYPENVEMGFPFQPIIECTKEEFFALPNIAKQEVIIKFTGETKDSPLVIQLENDS
Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.
Q8T116
Q92520
FAM3C_HUMAN
Interleukin-like EMT inducer
Homo
MRVAGAAKLVVAVAVFLLTFYVISQVFEIKMDASLGNLFARSALDTAARSTKPPRYKCGISKACPEKHFAFKMASGAANVVGPKICLEDNVLMSGVKNNVGRGINVALANGKTGEVLDTKYFDMWGGDVAPFIEFLKAIQDGTIVLMGTYDDGATKLNDEARRLIADLGSTSITNLGFRDNWVFCGGKGIKTKSPFEQHIKNNKDTNKYEGWPEVVEMEGCIPQKQD
May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
Q92520
Q9GV27
EIF3H_BOMMO
Eukaryotic translation initiation factor 3 subunit H
Bombyx
MASRAGSARRAPENEATIQYVQCDGLAVMKIVKHCHEESCSNMEVAQGALLGLVVENRLEITNCFPFPKHDDTMDEEEYQLDMMRRLRRVNVDHFHVGWYQSADVGNFLSLSLLESQYHYQTSIEESVVVIYDTKKSARGFLTLKAYRLTPQAIAMYKEGDYTPEALRNLKIGYENLFIEVPIVIRNSPLTNIMISELTEMIPEEEGSKFLDLGTASVLEGQLRSLMERVDELNQEAIKFNRYQQLVVRQQQDKHRWMVKRAQENAARAAKDETPLPEEDVNKLFKPHPVPPRLNPMIVAGQIDTYSQHISQFCSQSLAKLYLTQALQNAKEAKQNN
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
Q9GV27
Q08747
UAF30_YEAST
Upstream activation factor 30 KDa subunit
Saccharomyces
MAELNDYSTMIDILLSDMDLETVTTKKVRMALKEVYAIDVESQGKAINKLIRKHLDLVKERPRFERSLEDLLKENATLAIELTKEITVSKRSSGEEKNDSETKGTHVEKKKGTVSKSPISTRKVTLSKSLASLLGEHELTRTEVVRRLWAYIKAHNLQNPNNKKEILCDEKLELILGKSTNMFEMHKILASHMTEPKKISDCPPLIQEVRRKEKPIVSDSEQSDTKGI
Nonessential component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. Together with SPT15/TBP UAF seems to stimulate basal transcription to a fully activated level. UAF30 seems to play a role in silencing transcription by RNA polymerase II.
Q08747
Q9XIG2
PLM_ARATH
Protein PHLOEM UNLOADING MODULATOR
Arabidopsis
MTKGGLGIAAMSYVVIDYMRYVSPVWHSRLMPVLWSVLAIAVVTRVLFYKHWSKELRAAIPFLGSIVFLLCALLFEALCVRSVTAVLGLDWHRETPPLPDTGQWFLLALNESLPGTLVEILRAHIIGLHHFLMLFIMLGFSVVFDSVKAPGLGLGARYIFTMGVGRLLRAITFVSTILPSARPWCASARFNNVPSQPHRWAQKYYVPYANDPAAIRKLLHWDAAYADPGSYIGDYRADWGSMSFLSEFLRPSYSEGSSWFALLKKAGGGCNDLMYSGHMLVAVLTAMAWTEAYGGFSSAMIWLFVAHSAQREIRERHHYTVDCIVAIYVGILLWKMTGFIWSAERKTKQTKLEKIQNSLIHAAKDGDIETVRRLVEEIEVSSRVEKQSKVISNRTMTVFACATVITTLTIVILALTLTSDG
Catalyzes the biosynthesis of sphingolipids with very long-chain fatty acid (VLCFA) . Required for the formation of plasmodesmal cytoplasmic sleeve during the transition from type I to type II plasmodesmata to modulate post-sieve elements (SE) unloading and symplastic cell-to-cell molecular trafficking at the phloem pole pericycle (PPP)-endodermis interface in roots .
Q9XIG2
Q839E5
RL15_ENTFA
50S ribosomal protein L15
Enterococcus
MKLHELKPAEGSRQVRNRVGRGTSSGNGKTAGRGQKGQKARSGGGVRLGFEGGQTPLFRRLPKRGFTNINRKDYAVVNLDTLNRFEDGTEVTPVVLKEAGIVKNEKAGIKVLADGELTKKLTVKAAKFSKSAQEAIEAAGGSIEVI
Binds to the 23S rRNA.
Q839E5
A0A075B6X5
TVA18_HUMAN
T cell receptor alpha variable 18
Homo
MLSASCSGLVILLIFRRTSGDSVTQTEGPVTLPERAALTLNCTYQSSYSTFLFWYVQYLNKEPELLLKSSENQETDSRGFQASPIKSDSSFHLEKPSVQLSDSAVYYCALR
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity .
A0A075B6X5
Q0C668
RIMM_HYPNA
Ribosome maturation factor RimM
Hyphomonas
MSADTKTQRLIPMGVLKGAHGVRGEVRVKSFTADPDALFTYGPLMDEAGKVLLTPITARPGKDHFIVRPKENLQKEDWDALRGCLLHASRDQLPEADEDEFYFEDLIGMPVYTVGEEPEARVRAVQNFGSGDLLEIEIPGAPATIYVPLTRADVPVIDMAAHRIVIPELSLWANQDEDDAS
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Q0C668
P39885
TCMR_STRGA
Tetracenomycin C transcriptional repressor
Streptomyces
MDSAETDTPSTRSTPNGPGLRQRKLRRTRDQLIREALELFLAQGYEHTTVEQIAEAVEVHPRTFFRHFASKEEVALTPISAIDEAFLAALEVRPAGENPLQAMSGAFRAVLGRVRDGELEGVDGALHMAMMRLVERTPGLLAEYLRRSEEMEGRLARIIAAREGVDLDDDFRPRFIVAVFKAVGRVVSREWYLRADTDLEALSVAFESALDSLRPELFADWRRPGA
Represses transcription of the divergently oriented tcmR and tcmA (tetracenomycin C resistance and export) genes by binding to an intergenic operator region. This binding is inhibited by tetracenomycin C.
P39885
Q82JD2
PTA_STRAW
Phosphotransacetylase
Streptomyces
MTRSVYVTGIDRGDGRQVVELGVMELLTRQVDRVGVFRPLVHDGPDRLFELLRARYRLAQDPATVYGMDYHEASALQAEQGTDELMSTLVDRFHLVARDYDVVLVLGTDFADTQFPDELALNARLANEFGAAVIPVVGGRGQTAESVRAETRNAYRAYEGLGCDVLAMVVNRVAREDREELAARLDSLLAVPCYVLPDEPALSAPTVAQITHALGGKVLLGDDSGLARDALDFVFGGAMLPNFLNALTPGCLVVTPGDRADLVVGALAAHSAGTPPIAGVLLTLDERPSDEVLTLAARLAPGTPVVSVAGTSFPTAAELFSLEGKLNAATPRKAETALGLFERYVDTGDLLKRVSAPSSDRLTPMMFEHKLLEQARSDKRRVVLPEGTETRVLHAAEVLLRRGVCDLTLLGPVDQIRKKAADLGIDLGGSQLIDPVTSQLRDSFAEKYAQLRAHKGVSVELAYDVVADVNYFGTLMVQEGLADGMVSGSVHSTAATIRPAFEIIKTKPDTKIVSSVFFMCLADKVLVYGDCAVNPDPNAEQLCDIAVQSAATARQFGVEPRIAMLSYSTGTSGSGADVDKVREATELVRLRRDDLKIEGPIQYDAAVEPSVAATKLPGSDVAGQASVLIFPDLNTGNNTYKAVQRSAGAIAVGPVMQGLRKPVNDLSRGALVQDIVNTVAITAIQAQSPHEKATAQ
Involved in acetate metabolism.
Q82JD2
Q39Z66
DAPB_GEOMG
4-hydroxy-tetrahydrodipicolinate reductase
Geobacter
MVKIAVCGAAGRMGQRIIVAAKEAGCTVSGALERPGHELVGQDAGLIAGCGALGVAISDDLNAVVDGCDVLIDFTTPKVSLKNLEACALKKKAIVIGSTGFTPEERALAAELAKDIPAVLAPNMSVGVNVCFKILKDVAKTLGDDFDVEIVELHHNKKKDAPSGTAVRMGEVVAEALGRDYNKVANYHREGICGERTKEEIGMQTVRGGDIVGEHTVYFIGMGERIEISHRAMTRDMFSRGSVRAAQWVVGKAPGLYDMQDVLGLR
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Q39Z66
A2BQ26
CHLN_PROMS
Light-independent protochlorophyllide reductase subunit N
Prochlorococcus
MSKVEFNKETGPREVFCGLTSIVWLHRRMPDAFFLVVGSRTCAHLIQSAAGVMIFAEPRFGTAILEEKDLAGLADAHEELDRVVNDLIARRPEIKTLFLVGSCPSEVIKLDLATVAEKLNKRFLGQVRFVNYSGSGIETTFTQGEDGALKALIPLMESSNEEKLLLVGTLANNVEDRFKKIFKNLGISNIESFPPRQSTELPKIGKNTKVLLTQPYLSDTVRDLKHRGCEIISAPFPLGIEGSTEWFLAAAKAFKINELKVHEILSPLINRAKLALESHKEILKGKRLFLLPESQLEISLARFLHNECEMDLVEVGTPYLNKDLMKEEINLLPDNTKIVEGQHVEKQLDRVRESNPDLVVCGMGLANPLEAEGISTKWSIEMVFSPIHGIDQAADLAGLFSKPLRRNQILTTKTLVTH
Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex.
A2BQ26
Q09MH8
PSAA_CITSI
PsaA
Citrus
MIIRSPEPEVKILVDRDPVKTSFEEWAKPGHFSRTIAKGPETTTWIWNLHADAHDFDSHTSDLEEISRKVFSAHFGQLSIIFLWLSGMYFHGARFSNYEAWLSDPTHIGPSAQVVWPIVGQEILNGDVGGGFRGIQITSGFFQLWRASGITSELQLYCTAIGALIFAALMLFAGWFHYHKAAPKLAWFQDVESMLNHHLAGLLGLGSLSWAGHQVHVSLPINQFLNAGVDPKEIPLPHEFILNRDLLAQLYPSFSEGATPFFTLNWSKYAEFLTFRGGLDPVTGGLWLTDIAHHHLAIAILFLIAGHMYRTNWGIGHGLKDILEAHKGPFTGQGHKGLYEILTTSWHAQLSLNLAMLGSLTIIVAHHMYSMPPYPYLATDYGTQLSLFTHHMWIGGFLIVGAAAHAAIFMVRDYDPTTRYNDLLDRVLRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMSALGRPQDMFSDTAIQLQPVFAQWIQNTHALAPGGTAPGATASTSLTWGGVDLVAVGGKVALLPIPLGTADFLVHHIHAFTIHVTVLILLKGVLFARSSRLIPDKANLGFRFPCDGPGRGGTCQVSAWDHVFLGLFWMYNAISVVIFHFSWKMQSDVWGSISDQGVVTHITGGNFAQSSITINGWLRDFLWAQASQVIQSYGSSLSAYGLFFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKLKVAPATQPRALSIVQGRAVGVTHYLLGGIATTWAFFLARIIAVG
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin.
Q09MH8
Q9M9L7
LONM4_ARATH
Lon protease homolog 4, chloroplastic/mitochondrial
Arabidopsis
MLKFLTPTAYASHHVTPATRFRSTPVKNLLFKQLTLLTGWNRSSYELGRRSFSSDLDSDTKSSTTTVSAKPHLDDCLTVIALPLPHKPLIPGFYMPIYVKDPKVLAALQESRRQQAPYAGAFLLKDDASSDSSSSSETENILEKLKGKELINRIHEVGTLAQISSIQGEQVILIGHRQLRITEMVSESEDPLTVKVDHLKDKPYDKDDDVIKATYFQVMSTLRDVLKTTSLWRDHVRTYTQACSLHIWHCLRHIGEFNYPKLADFGAGISGANKHQNQGVLEELDVHKRLELTLELVKKEVEINKIQESIAKAVEEKFSGDRRRIILKEQINAIKKELGGETDSKSALSEKFRGRIDPIKDKIPGHVLKVIEEELKKLQLLETSSSEFDVTCNYLDWLTVLPWGNFSDENFNVLRAEKILDEDHYGLSDVKERILEFIAVGGLRGTSQGKIICLSGPTGVGKTSIGRSIARALDRKFFRFSVGGLSDVAEIKGHRRTYIGAMPGKMVQCLKNVGTENPLVLIDEIDKLGVRGHHGDPASAMLELLDPEQNANFLDHYLDVPIDLSKVLFVCTANVTDTIPGPLLDRMEVITLSGYITDEKMHIARDYLEKTARRDCGIKPEQVDVSDAAFLSLIEHYCREAGVRNLQKQIEKIFRKIALKLVRKAASTEVPRISDDVTTDTEETKSLAKTDLESPETSAEGSTVLTDELATGDPTESTTEQSGEVAETVEKYMIDESNLSDYVGKPVFQEEKIYEQTPVGVVMGLAWTSMGGSTLYIETTFVEEGEGKGGLHITGRLGDVMKESAEIAHTVARRIMLEKEPENKLFANSKLHLHVPAGATPKDGPSAGCTMITSLLSLALKKPVRKDLAMTGEVTLTGRILAIGGVKEKTIAARRSQVKVIIFPEANRRDFDELARNVKEGLEVHFVDEYEQIFELAFGYDH
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.
Q9M9L7
Q3JDR4
RF1_NITOC
Peptide chain release factor 1
Nitrosococcus
MKDSIRSKLETLAERQQELTALLAEPEIASAQKKFRELSQEYAQLEPVIGCFRDFEQAQSVLNESKALLQDQDPELRVLAQEEIAAAEKKLERLDRELHTLLLPSDPNDKRNIFLEIRAGTGGDEAALFASDLLRMYLRYAEQRGWRTEIMGDSPGEHGGHKEIIVRIVGAGAYSRLKFESGGHRVQRVPQTESQGRIHTSACTVAIMPEAEEIDDIDINPADLRVDTFRASGAGGQHVNKTDSAIRITHLASGIVVECQDERSQHKNRARAMSLLRTKLKSEEEAKLVAEETATRRSLIGSGDRSERIRTYNFPQGRVTDHRINLTLYKLDEILQGNLDAIIDPLVAEHQADQLAALSD
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
Q3JDR4
Q7U3L0
SPEE_PARMW
Spermidine synthase
Parasynechococcus marenigrum
MGGWIDEEHRGVRYGLAGDVLVEETSPFQRISVIRSERYGKGLLLDGCWMTAEQQERHYHEALVHPALCSAEAIERVLVIGGGDGGTARECLRYPEVIHLDLVEIDGRVVELSQEHLPGIGGAVWSDSRCQLTVGDGIAWAANAPDQSYDVVLVDGSDPAGPAEGLFNRAFFEHCRRILKPGGVFATQSESPEAFREVHVAMVRLLREVFGHADPLYGWVPMYPSGWWSWTFAAVDGPRYRTVQPARAALVAEGCEIWSPRWQQGALDAVPAFIARELAP
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Q7U3L0
Q96190
COX2_RHIUN
Cytochrome c oxidase polypeptide II
Rhinoceros
MAYPLQLGFQDATSPIMEELLHFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQEVETIWTILPAIILILIALPSLRILYMMDEINNPSLTIKTMGHQWYWSYEYTDYEDLTFDSYMIPTSDLKPGELRLLEVDNRVVLPMEMTIRMLISSEDVLHSWAVPSLGLKTDAIPGRLNQTTLISTRPGLYYGQCSEICGSNHSFMPIVLELVPLKHFEKWSTSML
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Q96190
Q50265
RS19_ASTYP
30S ribosomal protein S19
Candidatus Phytoplasma asteris
MPRSVKKGPIVASHLLAKIEKQKNLKNKKVIQTWSRSSTITPIFVGHKIAVYNGREHIPVYITENMVGHKLGEFSPTRTYRGHNKKDKKIQKK
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Q50265
Q4UXZ0
MSCL_XANC8
Large-conductance mechanosensitive channel
Xanthomonas
MGMVSEFKQFAMRGNVIDLAVGVVIGAAFGKIVTALVEKIIMPPIGWAIGNVDFSRLAWVLKPAGVDATGKEIPAVVIGYGDFINTVVQFVIIAFAIFLVVKLINRLSQRKPDAPKGPSEEVLLLREIRDSLKNDTLKNPTVP
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
Q4UXZ0
Q9RXX6
IXTPA_DEIRA
Nucleoside-triphosphate pyrophosphatase
Deinococcus
MQQQTGGRRRQIRRVVVATSNAGKVRELQGALAPLGWQCEGLGAVTLPEETGSTYEENAALKACAAAMATGLPALADDSGIEVLALGGQPGVYSARFGNVNSDVERNVLLLEKMRRHTDRRAKFVSVLVLAYPDGKLEEYRGEVTGQLLEGPRGESGFGYDPLFLPDGSELSMGEMTLEQKQAISHRGQALAALLAAHGA
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Q9RXX6
B2HFW2
ARC_MYCMM
Mycobacterial proteasome ATPase
Mycobacterium
MADSERSEAFGTPDDTPLSSNDAAELEQLRREAAVLREQLESAVGPQGTARSARDVHQLEARIDSLAARNSKLMETLKEARQQLLALREEVDRLGQPPSGYGVLLSTHDDDTVDVFTSGRKMRLTCSPNIEISLLRKGQTVRLNEALTVVEAGTFESVGEISTLREVLADGHRALVVGHADEERIVWLAEPLVAEDLPDGFPDALNDDTKPRKLRPGDSLLVDTKAGYAFERIPKAEVEDLVLEEVPDVSYEDIGGLTRQIEQIRDAVELPFLHKELYREYALRPPKGVLLYGPPGCGKTLIAKAVANSLAKKMAEVRGDDSREAKSYFLNIKGPELLNKFVGETERHIRLIFQRAREKASEGTPVIVFFDEMDSIFRTRGTGVSSDVETTVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERPDAEAAQDIYSKYLTETLPVHADDLAEFEGERPACIKAMIEKVVDRMYAEIDDNRFLEVTYANGDKEVMYFKDFNSGAMIQNVVDRAKKNAIKSVLETGQPGLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLVTGKSSSASRAIDTESNLGQYL
ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
B2HFW2
A6LU43
NUSB_CLOB8
Antitermination factor NusB
Clostridium
MNRKLSREKAMELLFGMTLSKDTMEDAVEAFVENYEGDIKEIDLTYVKQVLIGVNNNKEAIDKVIQENLHNWKIERISKVNLSILRIATYELLYDKEVPRGVAINEALEITRRYSDEKSVSFINGVLDKIKQD
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
A6LU43
Q9PGS5
TGT_XYLFA
tRNA-guanine transglycosylase
Xylella
MSRLQFQLQATDGAARRGQLSFPCGTVQTPAFMPVGTYGAVKGVLPGQLCDLGAEIILGNTFHLFLRPGLEVIADHGGLHGFMRWNGPILTDSGGFQVFSLAHRRKISEQGVTFAAPTDGAQVFLGPEESMKIQKVLNSDIVMIFDECTPYPATEDVARDSMELSLRWAQRSRDAHDALDNDAALFGIIQGGVHPDLRGRSLDGLQAIGFDGYGIGGLAVGESESERNVILEYLHPRVPADRPRYLMGVGRPEDLVESVARGVDMFDCVMPTRHARNGQYFTGFGTVKIRNACYARDVDPIEPGCGCPACVGGYTRAYLRHLDRCNEMLASMLGTLHNLWYYETLMANMRAAITAGTFFAFRRSFYLARGLDLPPLPEVAGCAG
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Q9PGS5
P17709
HXKG_YEAST
Glucose kinase 1
Saccharomyces
MSFDDLHKATERAVIQAVDQICDDFEVTPEKLDELTAYFIEQMEKGLAPPKEGHTLASDKGLPMIPAFVTGSPNGTERGVLLAADLGGTNFRICSVNLHGDHTFSMEQMKSKIPDDLLDDENVTSDDLFGFLARRTLAFMKKYHPDELAKGKDAKPMKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKDVVQLYQEQLSAQGMPMIKVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIFGTGTNGCYMEEINKITKLPQELRDKLIKEGKTHMIINVEWGSFDNELKHLPTTKYDVVIDQKLSTNPGFHLFEKRVSGMFLGEVLRNILVDLHSQGLLLQQYRSKEQLPRHLTTPFQLSSEVLSHIEIDDSTGLRETELSLLQSLRLPTTPTERVQIQKLVRAISRRSAYLAAVPLAAILIKTNALNKRYHGEVEIGCDGSVVEYYPGFRSMLRHALALSPLGAEGERKVHLKIAKDGSGVGAALCALVA
Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake.
P17709
A1RI59
SSTT_SHESW
Na(+)/serine-threonine symporter
Shewanella
MKQESSLLAKLANGSLVLQILLGIAAGVILASFSQDAAKQVAFLGSLFVGALKAIAPILVFILVASSIANQKKNTQTNMRPIVVLYLFGTFAAALTAVVLSSIFPTNLVLVAGIEGTSPPQGIGEVINTLLFKLVDNPVNALMTGNYIGILAWGVGLGLALHHANDSTKQVFADMSHGISQMVRFIIRLAPIGIFGLVAATFAETGFAAIAGYAQLLAVLLSAMAIIALIVNPLIVYVKIKRNPYPLVLRCLRESGVTAFFTRSSAANIPVNMALCEKLNLNKDTYSVSIPLGATINMGGAAITITVLTLAAVHTLGIQVDLPTALLLSVVAAVSACGASGVAGGSLLLIPLACSLFGISNDIAMQVVAVGFIIGVIQDAAETALNSSTDVIFTAAACEAAENKAKLG
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
A1RI59
O34453
NOSO_BACSU
NOSoxy-like protein
Bacillus
MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
Catalyzes the production of nitric oxide.
O34453
Q3II28
RISB_PSET1
6,7-dimethyl-8-ribityllumazine synthase
Pseudoalteromonas
MKIIEGSKYAPGKKFAIVISRFNDFIGSSLLAGAIDELKRTGGVSDDDITVVYVPGAVELPLAAKRIAAKKQYDAIIALGVVIRGGTPHFDLVAGESNKGLAQVSLEYDIPVAFGVLTTESIEQAIERAGTKMGNKGGEAALGALEMVNVLDKI
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Q3II28
P46613
PSBF_BETVU
PSII reaction center subunit VI
Beta
MTIDRTYPIFTVRWLAVHGLAIPTVSFLGSISAMQFIQR
This b-type cytochrome is tightly associated with the reaction center of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
P46613
Q0V8T7
CTP5C_MOUSE
Contactin-associated protein-like 5c
Mus
MDSVPRLNSVFTLVLSGLWHFGLTATNYNCDDPLTSFLSLRAFSSSSDLTGRSSPAQLNWRMGTGGWSPADSNAQQWLQMDLGNRVEITAVATQGRYGSSDWVTSYRLMFSDTGHNWQQYTQEGSIWRFVGNMNANSVVHHKLLNSVRARFVRFVPLEWNPNGKIGMRVEVYGCSYRSDVADFDGWSSLLYRFNQKTMSTLKDVISLKFKSIQRDGVLFHGEGQRGDHITLELQNGRLALYLNLDDSKAQVSSTAPLATLGSLLDDQHWHSVLLERVGKQANFTVDKNTQHFQTKGETDALDIDYELSFGGIPVPSKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYSGNVTFSCSEPQTVPITFVNSRSSYLLLTGTPQIDGLSVSFQFRTWNEDGLLLSTELSEGSGTLLLILEGGTLRLLIKKLARHGTEIFTGSGLNDGMWHSVSISARRNRVTLTLDNDAASLPPDTSWLQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQGSLGSFSDLHIDLCSIKDRCLPNYCEHGGQCAQTWTNFYCNCSDTGYTGATCHDSIYEQSCEVYRHRGKTAEFFYVDSDGSGPLGPLQVFCNITEDKIWMTVQHNNTGLTWVQGSNPEKPYAMTLNYGGSLEQLEALIDGSEHCEQEVTYYCKRSRLLNTPDGVPFTWWIGRSNEKHPYWGGSLPGVQQCGCGLEESCLDIRHFCNCDADTDEWTNDTGYLSFKDHLPVTQIIITDTNRSKSEAAWRIGPLRCYGDRHFWNAVSFSTEASFLHFPTFRVEFSADIFFFFKTTALSGVFLEILGIKDFLRLEMSSPSEVIFAIDVGNGPIDLLVQSPYPLNDNQWHYIRAERNLKETSLQVDNLPQSMREASEEGHFQFQLNSQLFVGGKSSRQKGFFGCIRSLHLNGQNIDLEERAKVTSGVRPGCPGHCSSYGRNCQNGGKCVEKHIGYSCDCTNSPYEGPFCQKEISALFDSDTSVTYMFQEPYSVTKNTNLSSSAIYTDTAPSKEIIMLSFMTAQAPTLLLYLNFSSQNFLAILLSWNGSLQIHYQLSKEESHVFTINTENLANRRVHQVKMSRDGPELSIQMDQQLFSYTFSLESEFQRARSLVLGKVTETLGLDPEVARANTLGFVGCLSSVQYNHITPLKAALRHASISPVTVQRTLTESSCVSMVDSDANAVTTVYSSTDPFGERDEREPLTNAVPSDLAVIGGIIAVVTFISFSVIGIMTHFFYQHKRSHYASQMKEKEYPENVDSSSRNDIDLQNTTRECKQEDFI
May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.
Q0V8T7
P49959
MRE11_HUMAN
Meiotic recombination 11 homolog A
Homo
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis . The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 . RAD50 may be required to bind DNA ends and hold them in close proximity . This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point . The complex may also be required for DNA damage signaling via activation of the ATM kinase . In telomeres the MRN complex may modulate t-loop formation .
P49959
A4IX64
MURG_FRATW
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Francisella
MSLENKNIIITAGGTGGHIYPALAIAELLRQNKANVTWVGTPNSMEASIVPEYFNIQFIKSSGVRRKGIIKKITFPLKLAYNTLKSRSLLKKLKADLVIGFGGYVSGPICLAAAQINIPVIIHEQNAKIGLTNRILAKFATTICLAFEIENLHKQFSSKQLAKTKIVGNPVRKDIVALNDKARIYTDSSTLKILVLGGSQGAKAINEIIPKLIQKSNEQGINIKVWHQTGKLSLEETKDAYKDISQNHIKDIAAFIDDMAIAYNWADLVICRAGALTVSECAIAGLPAIFIPLPSAVDDHQFFNAQNIVNNNAGFCLRQQQMTLENLLAIIKPLNQDRSKLEQMSKMAKKTLIKNSSEQILDCVKKILNNK
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
A4IX64
O78514
PSBH_GUITH
Photosystem II reaction center protein H
Guillardia
MALRTRLGELLRPLNSEYGKVAPGWGTTPAMGFVMLLFFLFLLIILQIYNSSLILENVDVDWASLGN
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
O78514
Q6M183
MPTA_METMP
GTP cyclohydrolase IV
Methanococcus
MQCNDVQATEPDIKVSLTRVGVTNLKKLVKLKRKNKRDIVLLPTFEVFVDLPSSQKGIHMSRSPEVIEEVVENILLEKEIYGVEDLSVEIVMKLFEKHEYATRAEVMLYSDYMMEEKSPVTKKDSQEIGKIIARAYGVKDSNGKIDVKKMVGAEVVGITACPCAQNMLKENAVVSLTEKGFSSEDIEKILDSVTIATHNQRGIGTVMIEVPNGYTVGISKIIKIIKDSMSGEVYELLKRSDEAFVVEAAHKNPKFVEDCAREMIKRVVDVFDYLPEDTQVLVRQVNKESIHRHDAFAERNSTIRELRDELKTLTN
Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
Q6M183
Q5E8W9
THIC_ALIF1
Thiamine biosynthesis protein ThiC
Aliivibrio
MSSSRKQARLDAKTNIESLSVQPYPNSNKVYIEGSRPDIRVPMREISLADSLVGGTKESPIFEPNEPIQVYDTSGVYTDPSYDIDVYKGLPKLRQEWIEERNDTELLDGVSSVYSQERLADETLDELRYGNLPTIRRAKQGQCVTQLHYARQGIITPEMEYIAIRENMGRQKFADEQLNHQHPGHSFGANLPKEITPEFVRREVAEGRAIIPSNINHPEAEPMIIGRNFLIKVNANIGNSSVSSSIEEEVEKLVWSTRWGGDTVMDLSTGRNIHETREWILRNSPVPIGTVPMYQALEKVNGVAENLNWEVMRDTLIEQAEQGVDYFTIHAGLLLRYVPMTAKRVTGIVSRGGSIIAKWCLAHHQESFLYTHFREICEICAKYDVALSLGDGLRPGSVADANDEAQFAELRTLGELTKVAWEYDVQVIIEGPGHVPMHMIKENMDEQLKHCHEAPFYTLGPLTTDIAPGYDHITSGIGAAMIGWYGCAMLCYVTPKEHLGLPNKDDVKTGLITYKLAAHAGDLAKGHPGAQIRDNALSKARFEFRWEDQFNLSLDPITAREYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVREYAKDSEQVALDQAIEIKMIDDPLEGMRQKSEEFKASGSELYHPVVEAE
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Q5E8W9
Q7VR53
PDXH_BLOFL
Pyridoxal 5'-phosphate synthase
Candidatus Blochmannia
MLELSKIHNLRREYISKQFRRSNLTKNPMHLFSKWLYEAYCQIPDPNAMCLSTVDHTGQPFQRLVLLKYFNDKTIVFFTHLNSRKAIHINNNPKISLCFPWNIINRQIIITGSVYKISKKEAQKYFYTRPKNNQISTWASKQSTIISSKKVLKNKFLKLKKKYFQKSVPFPHFWVGYKININSMEFWQGGIYRLHDRFLYKKNKKKWYINRLSP
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
Q7VR53
Q83AC6
LPTD_COXBU
LPS-assembly protein LptD
Coxiella
MKQGKSFIFYCLVLLLCGFQQLSSAVTASIAKAIKTTDRKQRVSETLPTGLSYRRFYQHIAHLLGWVPAPDLVCRGYFKEPLILTEHPHPGPATKEPAIVTAKGPSMVTAQGVSILRKDVVVTQPGRIVEADKAYIYRDSKTGHVTKIILIGHVRLHEADKRIVADKGTLTLYPKTAILMNAAYHIYNGEPYFYKFKYPFDAWGIAKHAVRDASNVITLRHATYSTCKPTAPAWSMSATTLVLNRNTHRGEAYNMLLHIGRVPIFYFPYFNFPIDNYRKTGFLIPYAGHSSSSGWFFALPFYWNMAPNYDLTLTPEFMSERGLNLQSLFRFLSTKSSGTIYLNYLPNDKVFQQFRETTLSKFPPSVLAEHPVFIPYVDKLKKMKNQRAFFSMNETTLFNSEWSSRVILNYVTDPYFFQDLGGQLGGSSLANQLLNQIDLQYNGLHWQFMGMLQAYQTLHLISQWTTPALDQYSRLPDFNIVGYYPDIARHVDFNFNAEAVNFDYRSDFVPDKPRGQRFHMRPGISFPFYFASGYIIPQLWADATAYNITHFQPGQAHTSSRLLPIFDIDSGLYFDRNFHLGHRSFIQTLEPRFFYLYVPYQNQDRFPNFDTVLLPFSFEQLFALNQFTGNDRLQNANQASFALTSRVLDAQNGSPILTANVGFIYYLENQRVCLTPGCTPSNYHYSPIIGELTFYPFPYWSFTGSLAWDPNLGQTNNTSVELAYNNGGKKADIRYLFVHGNEDSIVTPTTLIVPGNAYSQNTNHVISSGAWPLLKKWNAVGYWDYNITERRTDVYSIGVQYNTCCWALSFSIRRTYAGLKVDPNGALQRQYDTAYGFELQLKGLGNLGTAPISTVTVLDAMNNGVSNDVR
Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
Q83AC6
Q9S6S1
PEPQ_LACDE
Proline dipeptidase
Lactobacillus
MNLDKLQNWLQENGMDVAYVSSPTTINYFTGFITDPEERIFKLFAFKDAEPFLFCPALNYEEAKASAWDGDVVGYLDSEDPWGKIAEEIKQRTKDYQNWAVEKNGLTVAHYQALHAQFPDSDFSKDLSDFIAHIRLFKTESELVKLRKAGEEADFAFQIGFEALRNGVTERAVVSQIEYQLKLQKGVMQTSFDTIVQAGKNAANPHQGPSMNTVQPNELVLFDLGTMHEGYASDSSRTVAYGEPTDKMREIYEVNRTAQQAAIDAAKPGMTASELDGVARKIITDAGYGEYFIHRLGHGIGMEVHEFPSIANGNDVVLEEGMCFSIEPGIYIPGFAGVRIEDCGVLTKEGFKPFTHTSKELKVLPVKE
Strict dipeptidase active on Xaa-Pro dipeptides, except Gly-Pro and Pro-Pro.
Q9S6S1
Q5U2P6
PIANP_RAT
Paired immunoglobin-like type 2 receptor-associating neural protein
Rattus
MWPAQLLSQLLPLWPLLLLPLSLPAQGSSHRSPPAPARPPCVRGGPSAPRHVCVWERAPPPSRSPRVPRSRRQVLPGTAPPATPSGFEEGPPSSQYPWAIVWGPTVSREDGGDPNSVNPGFLPLDYGFAAPHGLATPHPNSDSMRDDGDGLILGETPATLRPFLFGGRGEGVDPQLYVTITISIIIVLVATGIIFKFCWDRSQKRRRPSGQQGALRQEESQQPLTDLSPAGVTVLGAFGDSPTPTPDHEEPRGGPRPGMPQPKGAPAFQLNR
Acts as a ligand for PILRA in neuronal tissues, where it may be involved in immune regulation.
Q5U2P6
A6WIP6
RIMO_SHEB8
Ribosome maturation factor RimO
Shewanella
MTVETFKPKQTTTLDIPVKTLEAASTNAVTTGNRIGFVSLGCPKNLVDSERILTQLRIDGYEVTNSYDNADLVIVNTCGFIDAAVEESLDAVREALEENGKVIVTGCLGAKENQIREVHPDVLEITGPHSYEAVLKHVHKYVPKPEHNPFTSLIPQTGVKLTPKHYAYLKISEGCDNRCTFCIIPSLRGDLDSRPAGSILDEAKRLVESGVQEILVVSQDTSAYGKDKGGRTDFWNGMPVKQDITSLARQLGKMGAWVRLHYIYPYPWVDDLIPLMAEGLILPYLDIPMQHASPRILKMMKRPGRVDRQLEAIQRWREICPDLVIRSTFIVGFPGETEEDFQILLDFLKEARLDRVGCFKYSEVDGAVANTIAELISEDVKEDRYHRFMEVQAEISAERLARFVGRTLDILIDDVDEEGAIGRSFADAPEIDGMVFINGETELEPGMLVRARITHSDEHDLWAEVVDADTQD
Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.
A6WIP6
Q7TQN9
GP142_MOUSE
Probable G-protein coupled receptor 142
Mus
MHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
Orphan receptor.
Q7TQN9
O94287
YOO2_SCHPO
Uncharacterized chloride channel protein C887.02
Schizosaccharomyces
MKDDQLIDWIHERYEEQKSANRLAGRFRFLGLETKYSIISIISGIFIGLTAALLNALASLLNSFREGYCTVNILFDKQTCCSTLTEDYECQEFFFWRNNHSVFVSCLIYVSVSVGFAFIATTLGYVVAPAARASGIPTIKAILSGYKYPDMNVFFSIKTLCSKSLAVCFSVASGLWVGKEGPFVHIATNIIYLVERIAPSLADSEIFTRQLLAAAMASGIAASFNAPVGGVIFALEQLASSSFPSLFTGSIWYEFLCSASSVVALQLIRSWHTDVGYLSYVSLDRRWSYKDTLPFIFISILCGCLGSVLIYLNMKFASKTKGFSKISNVFFVIFLSLITSLTAYAILGESELLFNPMELFPQVINSCSPSSSTVLCETTFWVTAIVLFTSALLGLLLTSATFGAAIPTGIIVPSLAIGACIGRAVGTLLKSRFPSLAGTSIYGVIGSIAFLSSTTRLVVALVVILFELTGALNIALPLMLATLISKWVSDSIIETSIYDAWIQFRNIPYFPSSNSLKFSIPLNFPVRSPEQLVRLPIRSCSIEELERAMHDSSQSFFVVLKNDTEFFEGFISRNKVSELLNRRPMSSNMQTTDNTGLDPLRSASAPVDSTFDLFDYIHPTTFTLNYDTPPVLMLKLFKDAGITNLALLNHGKLHGVLTKIDIIEYAKKCKTHTGNTYSELPTGVTYETDIFNRADD
Voltage-gated chloride channel.
O94287
Q9PE41
CLPP_XYLFA
Endopeptidase Clp
Xylella
MDDVTKALNLVPMVVEQTSRGERAYDIYSRLLKERLIFLVGPIDDYMANLIVAQLLFLEAENPEKDINIYINSPGGVVTAGMAIYDTMQYIKPAVSTICVGQAASMGALLLASGASGKRYALPNSRVMIHQPLGGFQGQATDIDIHAREILALRARLNEILAKHTGQSLETIAHDTERDNFKSAVDAQAYGLVDQVLGQRPEELIQSS
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q9PE41
Q9HWK6
LYSC_PSEAE
PvdS-regulated endoprotease
Pseudomonas
MHKRTYLNACLVLALAAGASQALAAPGASEMAGDVAVLQASPASTGHARFANPNAAISAAGIHFAAPPARRVARAAPLAPKPGTPLQVGVGLKTATPEIDLTTLEWIDTPDGRHTARFPISAAGAASLRAAIRLETHSGSLPDDVLLHFAGAGKEIFEASGKDLSVNRPYWSPVIEGDTLTVELVLPANLQPGDLRLSVPQVSYFADSLYKAGYRDGFGASGSCEVDAVCATQSGTRAYDNATAAVAKMVFTSSADGGSYICTGTLLNNGNSPKRQLFWSAAHCIEDQATAATLQTIWFYNTTQCYGDASTINQSVTVLTGGANILHRDAKRDTLLLELKRTPPAGVFYQGWSATPIANGSLGHDIHHPRGDAKKYSQGNVSAVGVTYDGHTALTRVDWPSAVVEGGSSGSGLLTVAGDGSYQLRGGLYGGPSYCGAPTSQRNDYFSDFSGVYSQISRYFAP
Lysine-specific endoprotease . Involved in corneal virulence.
Q9HWK6
A4SJR5
IF2_AERS4
Translation initiation factor IF-2
Aeromonas
MAEVSVKQLATDIDTPVDRLLQQFVDAGISKSKADDLVSESEKQTLLAHLKKQHGGDELTAPARMTLQRKTKSTISVQGTGGKNKEVQVEVRKTRTYVKRSALEDEQRQAEAEETARLEAEEKARSEAENKVRLDAEEKARREAEQARREAEEKARIEAQSKARQAPQPAKAASSTAQQEAEKMAKREAEELKRQQEQTALQKAEELAAKKAEEARLMAEQNGPRWAEEEAARAKESSDYHLTTNKHAQAAEDELDRKEETSRRTAAAAVKAPKKAGRREDDRDSRNPRARKGKRGKMAMPNAMKHGFNKPAAVVNRDVVIGETITVAELANKMAVKGVEVIKAMMKMGAMATINQVIDQETAQLVAEEMGHKVVLRRENELEEAVLSDRDETSEAKSRAPVVTIMGHVDHGKTSLLDYIRKAKVAAGEAGGITQHIGAYHVETDSGMITFLDTPGHAAFTSMRARGAKSTDIVVLVVAADDGVMPQTIEAIQHAKAAEVPIVVAVNKIDKPEADPDRVKTELARYNVMSEDWGGDSQFVHVSAKSGEGIDDLLEAILIQSEVLELKAVVDGMASGVVIESFLDKGRGPVATVLVQEGTLRQGDIVLCGLEYGRIRAMRDELGREIKEAGPSLPVEILGLSGVPSAGDEATVVRDEKKAREVALYRQGKFRDVKLARQQKAKLENMFANMTEGEVSEVNVVIKADVQGSVQAICDALVQLSTDEVKVKIVGSGVGGITETDATLAAASSAILVGFNVRADASARKVIESESLDLRYYSVIYDLIDEVKQAMSGKLAPEYRQEIIGLAEVRSVFKSPKFGAVAGCMVTEGVVKRSNRIRVLRDNVVIYEGELESLRRFKDDVNEVRNGYECGIAVKNYNDVREGDQIEVYETIEIQRTL
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A4SJR5
Q1JDD1
SCPA_STRPB
Segregation and condensation protein A
Streptococcus
MDIKLKDFEGPLDLLLHLVSQYKVDIYEVPIVEVIEQYLNYIETLQVMKLEVAGDYMLMASQLMLIKSRRLLPKVVEHIEEEDLEQDLLEKIEEYSRFKAVSQALAKQHDQRAKWYSKPKQELIFEDAILQEDKTVMDLFLAFSNIMAAKRAVLKTNHTVIERDDYKIEDMMASIKQRLEKENVISLSAIFEECQTLNEVISIFLASLELIKLHVVFVEQLSNFGAIILRKEKK
Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.
Q1JDD1
Q96S96
PEBP4_HUMAN
Protein cousin-of-RKIP 1
Homo
MGWTMRLVTAALLLGLMMVVTGDEDENSPCAHEALLDEDTLFCQGLEVFYPELGNIGCKVVPDCNNYRQKITSWMEPIVKFPGAVDGATYILVMVDPDAPSRAEPRQRFWRHWLVTDIKGADLKKGKIQGQELSAYQAPSPPAHSGFHRYQFFVYLQEGKVISLLPKENKTRGSWKMDRFLNRFHLGEPEASTQFMTQNYQDSPTLQAPRERASEPKHKNQAEIAAC
Promotes AKT phosphorylation, suggesting a possible role in the PI3K-AKT signaling pathway.
Q96S96