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2.75k
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5.51k
AlphaFoldDB
stringlengths
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10
Q6DTN4
HYUC_RHIML
L-N-carbamoylase
Sinorhizobium
MAAPGENRRVNADRLWDSLMEMAKIGPGVAGGNNRQTLTDADGEGRRLFQSWCEEAGLSMGVDKMGTMFLTRPGTDPDALPVHIGSHLDTQPTGGKFDGVLGVLSGLEAVRTMNDLGIKTKHPIVVTNWTNEEGARFAPAMLASGVFAGVHTLEYAYARKDPEGKSFGDELKRIGWLGDEEVGARKMHAYFEYHIEQGPILEAENKQIGVVTHCQGLWWLEFTLTGREAHTGSTPMDMRVNAGLAMARILEMVQTVAMENQPGAVGGVGQMFFSPNSRNVLPGKVVFTVDIRSPDQAKLDGMRARIEAEAPKICERLGVGCSIEAVGHFDPVTFDPKLVETVRGAAEKLGYSHMNLVSGAGHDACWAAKVAPTTMIMCPCVGGLSHNEAEDISREWAAAGADVLFHAVLETAEIVE
May be involved in the asymmetric conversion of racemic 5-substituted hydantoins to the corresponding L-amino acids. Catalyzes specifically the conversion of N-carbamoyl-L-amino acids to free L-amino acids in an irreversible reaction. N-carbamoyl-L-methionine is the best substrate. HyuC of R.meliloti is the first L-N-carbamoylase that hydrolyzes N-carbamoyl-L-tryptophan as well as N-carbamoyl-L-amino acids with aliphatic substituents.
Q6DTN4
Q9HGI4
ERF3_ZYGRO
Translation release factor 3
Zygosaccharomyces
MSDPNQNGQQGGQQNAGGNYYQQYFQKLTQQAQAGGGYQPYGGYGGYGGYGGYQPYGGYQQFYQDGQQAQQGAYNGYPYQAQGAPGGFNNYNNQFQPQQQSQGMTLDDFHKQKQTSQSAPPKQKKSLKLVSSSGIKLANATKKPKEDEKKEEEPKKEEKKAEPKEQESKKEEPKREGTPRPAAAKDEKKEDLPKLEKLKIKEEQAAANASGADSLIKEQEEEVDEGVVNDMFGGKDHMSIIFMGHVDAGKSTMGGNILYMTGSVDKRTVEKYEREAKDAGKQGWYLSWVMDTNREERDDGKTIEVGRAYFETEKRRYTILDAPGHKMYVSEMIGGASQADVGILVISARKGEYETGFEKGGQTREHALLAKTQGVNKLIVTINKMDDPTVNWSKERYDQCVKNLSNFLKAIGYNVKEEVVFMPVSGYSGAGLGTRVDPKECPWYDGPALLEYMDNMSHVDRKMNAPFMLPIAAKMRDMGTIVEGKIESGHIRKGHSTLLMPNKIPVEIQNIYNETENEVDMAICGEQVKLKIKGVEEEDIAPGFVLTSPKNPVKNVTRFVAQVAIVELKSILSSGFSCVMHVHTAIEEVRITKLLHKLERGTNRKSKKPPAFAKKGMKIIAVLETERPVCVETYQDYPQLGRFTLRDQGTTIAIGKIVKIIE
Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides.
Q9HGI4
P17934
PA2A4_BUNMU
Phosphatidylcholine 2-acylhydrolase
Bungarus
MNPAHLLVLSAVCVSLLGAANIPPQHLDLYQFKEMIRYTIPCEKTWGEYADYGCYCGAGGSGTPIDALDRCCYVHDNCYGDAANIRDCDPKTQSYSYKLTKRTIICYGAAGTCARVVCDCDRTAALCFGNSEYIEGHKNIDTARFCQ
Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
P17934
Q1CCJ6
RNPA_YERPN
Protein C5
Yersinia
MVKLAFPRELRLLTPSHFTFVFQQPQRAGTPQITILGRLNELGHPRIGLTVAKKHVKRAHERNRIKRLTRESFRLHQHALPSMDFVVLVKKGVADLDNRALTEALEKLWRRHCRQAPAS
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
Q1CCJ6
Q5PBH2
EFG_ANAMM
Elongation factor G
Anaplasma
MSSKGDLSRCRNIGIMAHIDAGKTTTTERILFYTGKQNRIGEVHEGAASMDWMEQERERGITITSAATTCFWNDCRINIIDTPGHVDFTIEVERSLRVLDGAVAVFDGVAGVEPQSETVWRQADKYDVPRICFVNKMDRIGADFYACVDMIKDRLGAVPLVLQLPIGVDKSFVGVVDLVEMRSITWEEDSLGAKFNYGEIPSDLMEKAQDYRARLIESAVEMNDEAMNLYLDGGEISVPLLKSCIRSGVIGAKFVPVLCGSAFKNKGVQPLLDAVVDFLPSPSDIPTIEGASASDPQKAVTIKSSVDDKFVALAFKVMVDRFVGSLTFIRVYSGKLTGKSVVLNSAKGVTESVGRILRMHANNREDISEIQAGDIAALAGLKKTTTGDTLCDQNFPVVLEKMDFPESVMEIAVEPVSTADQEKMGTALSRLVAEDPSLKVCVNSESGQTILKGMGELHLEIIVDRMKREFGVEASVGAPQVAYRETITKSAEIEYVHKKQTGGAGQFAKVNILFEPLPPGSGFEFENKITCGAIPKEYIPGVQSGLELVKETGMIAGFPVIDFKATLFDGAFHEVDSSPLAFELAAKGAFREMANKAGPVLLEPIMRVEIITPDEYMGDVIGDVNSRRGRVAEMQDRHNAKLITAFIPLGKMFGYVKDLRSMSQGRAQYSMYFARYERVPENAVDNVMKK
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Q5PBH2
Q821T4
IPYR_CHLCV
Pyrophosphate phospho-hydrolase
Chlamydia
MSEKPSLSIMHPWHGPILTQDNYESLCCYIEITPQDSVKFELDKATGLLKVDRPQKFSNFCPCLYGLLPRTYCGELSGKYSGEQSLKENIQGDDDPLDICVLTEKNITHGNILLQARPIGGLRIIDSGEADDKIIAVLEDDLVFSEIQDISDCPCTVLDMIQHYFLTYKASPEHLIHGKPAKIEIVGIYGKKEAQKVIELAHQDYLNKFCREKTTI
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Q821T4
B1XKF6
DAPAT_SYNP2
LL-diaminopimelate aminotransferase
unclassified Synechococcus
MVRINENYLKLKAGYLFPEIARRVNGFLAENPNAPIIKLGIGDVTEPLPAACREAMAKAIDDMGDRANFKGYGPEQGYAWLREKIAAHDFQARGCDIDASEIFVSDGAKCDTGNILDIFGKDNTIAVTDPVYPVYVDTNVMAGHTGEADESGKYGGLTYIPITADNDFVAQIPTEKVDLIYLCFPNNPTGATATKEQLQAWVDYAKTNGSIIFFDAAYEAFITDESLPHSIYELEGAKDCAIEFRSFSKNAGFTGTRCAFTVVPKNLTVTASNGQAVQLWSLWNRRQSTKFNGVSYIVQRGAEAVYSEAGQAQIKTLIDFYLENAAIIRRELQAVGFDVYGGVNAPYVWVKTPAGLSSWDFFDKLLINCNVVGTPGSGFGAAGEGYFRISAFNSRENVLEAMKRITTAFQ
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
B1XKF6
A6V389
LEXA_PSEA7
LexA repressor
Pseudomonas
MQKLTPRQSEILSFIKRCLEDHGFPPTRAEIAQELGFKSPNAAEEHLKALARKGAIEMTPGASRGIRIPGFEPHAANDDEGLPVIGRVAAGAPILAEQNIEESCRINPAFFNPRADYLLRVRGMSMKDIGILDGDLLAVHVTREARNGQVVVARLGEEVTVKRFKREGSKVWLLAENPEFAPIEVDLKEQELIIEGLSVGVIRR
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
A6V389
Q9USM7
TIM23_SCHPO
Mitochondrial import inner membrane translocase subunit tim23
Schizosaccharomyces
MSWLFTRNKEEEPTSKIDSSELQVPTEATASDILSGSEFDPAKLHPLADLDKPLDYLLIEEDALSTLPGDSMAIPSRGWQDDLCYGTGTSYLSGLAIGGLWGLNEGMKKTKDITSTRLRLNGILNGVTRRGPFVGNSLGVLALVYNGINSLIGYKRQKHGWENSVAAGALTGALYKSTRGLRAMAISSSLVATAAGIWTLAKRSFTKRLN
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Q9USM7
Q5X0P0
ATPD_LEGPA
F-type ATPase subunit delta
Legionella
MSDSTTIARPYAKAIFEHALAEKKLSEWSEYLTLLAQVVLTPQATQFIANPASTDEQQIELLIEICGSKFKKNDALNNLIKLLTTNKRLMLLPEIKALYEVYRAEQEKILEVDVVSYSELTPAQQQRLSESLSQRLSRKVSLKISIDPSLLGGALIRAGDLVIDGSVRGKLNMLGTSLAA
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Q5X0P0
Q71Y88
AROB_LISMF
3-dehydroquinate synthase
Listeria
MPEITVRAKSKTYPVYINEFALEDVREKWTESLAKFSHVFVLTDEHVAELHQAKLDAVLADLPVVTYYVAPNGEEAKTFRVYEDVMTKLIETGLDRKAVLIAFGGGVIGDLGGFVAATYMRGIPFYQVPTTVLAHDSAVGGKVAINHPLGKNMIGNFYQPEAVIYDTQFFATLPEREMRSGFAEMIKHALISDQTLLRALMDTFTEPKDFYTKDLTPFLQRGIEIKANIVAQDETEQGVRAYLNFGHTFGHALEAYGNFGKWLHGEAITYGMIYALTMSETIYGLDFDLAEFKTWLKQLGYDTTFDATVPFNKILENMRHDKKTTFNEISMVLLEEIGEPVIFKAEDDLIFETYKRVMRNGGNGI
Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
Q71Y88
Q3J3V1
SELO_CERS4
Protein adenylyltransferase SelO
Cereibacter
MTFRFDNSYARDLEGFYVDWPAAPVPAPRLLRLNRPLAEELGLDPDLLEREGAEIFSGRRLPEGAHPLAQAYAGHQFGGFSPQLGDGRALLIGEITDRAGRRRDLQLKGSGRTPFSRGADGKAALGPVLREYLVGEAMHGLGIPTTRALAAVATGEPLLRQEGERPGAILTRVAASHIRVGTFQFFAARSDIDRVRRLADYAIARHYPELASAPEPYLAFYEAVAEAQAQLVARWMLVGFIHGVMNTDNMTISGETIDYGPCAFMEGYDPGTVFSSIDLQGRYAYGNQPYILAWNLARLGEALLPLLDGDPVRAADKATSVLETVGARYQGHWLAGMRAKLGLAGAEEGDARLAEDLLEAMRSQRADWTLTFRRLAEAVTDEGALRPLFRDPAALAGWLPRWRARLAPDAAERMRATNPIYIARNHRVEEALAAAHAGDLAPFDRLLEALADPFTERADRELFALPAPEGFDDSYRTFCGT
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
Q3J3V1
Q06SJ6
PSBC_STIHE
Protein CP-43
Stigeoclonium
METLYNGTLSLGGKDQESTGFAWWSGNARLINLSGRLLGAHVAHAGLIVFWAGAMNLFEVAHFVPEKPMYEQGLILLPHLASLGYGVGPGGEVIDTFPYFVSGVLHLISSAVLGFGGVYHSLIGPETLEETFPFFGYTWKDKNKMTSILGFHLIILGFGAWLLVWKAMYFGGVYDTWAPGGGDTRIITNPTTNPAVIFGYLLKSPFGGDGWIVSVDNMEDIIGGHIWIGTLEIFGGIWHIFTQPWAWTRRAFVWSGEAYLSYSLGAIALMGFVACCMGWFNNTAYPSEFYGPTGPEASQSQAFTFLVRDQRLGANVASAQGPTGLGKYLMRSPTGEIIFGGETMRFWDFRGPWLEPLRGPNGLDLNKLKNDIQPWQERRAAEYMTHAPLGSLNSVGGVATEINSVNFVSPRSWLATSHFCLGFFFFVGHLWHAGRARAAAAGFEKGIDRLTEPVLSLKPLD
One of the components of the core complex of photosystem II (PSII). It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of PSII. PSII is a light-driven water:plastoquinone oxidoreductase, using light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation.
Q06SJ6
O42499
NEUV_TAKRU
Neurophysin VT 1
Takifugu
MPQCALLLSLLGLLALSSACYIQNCPRGGKRALPETGIRQCMSCGPRDRGRCFGPNICCGEALGCLMGSPETARCAGENYLLTPCQAGGRPCGSEGGRCAVSGLCCNSESCAVDSDCLGETESLEPGDSSADSSPTELLLRLLHMSSRGQSEY
Vasotocin is probably an antidiuretic hormone.
O42499
Q7W3B3
DCUP_BORPA
Uroporphyrinogen decarboxylase
Bordetella
MSVAPLKNDVFLRALLREPVPYTPIWLMRQAGRYLPEYNATRARAGSFMGLAQNPDYACEVTLQPLARYPLDAAILFSDILTVPHAMGLGLDFAPGEGPRFAHPVRDESDVAKLAVPDMDSLRYVFDAVRTIRRELDGRVPLIGFAGSPWTIACYMVEGRGSDDYRLIKSMLYGRPDLLHRILEINAEATRHYLNAQIDAGAQAVMLFDSWGGVLADGLFQQFSLAYTRRVVEGLTREREGRRVPVIVFSKGGGQWLEEIAACGCDAVGLDWTVNLGTARRRVADAVALQGNLDPMTLFGGAQAVRAEARRTLDAFGPVGKGGHVFNLGHGISQYSPPEVVSELVDEVHTYSRALHAG
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
Q7W3B3
Q18235
IFY1_CAEEL
Interactor of Fizzy protein
Caenorhabditis
MEDLNFEERGSTQIPASLQQHFSAKLGRQNELEKTPSRGGLGLVVNSSKTPGGKSLQSLASACKVPPSTKKNTIPIAFECYEDETDDQIADVATIKKTEKHPCSPIDTANRCETFDSLAADIEDDMLNLEDQDVVLSEDRPYGDVIDPAESEAEALAELGVEEWDSYPPIDPASRIGDDFNYVLRTEDFAEEGDVKLEETRHRTVIADIDEVKMSKAERNELFSMLADDLDSYDLLAEEANLPL
Acts as a chaperone and as an inhibitor for separase sep-1 . Plays an essential role in maintaining chromosome cohesion prior to meiotic and mitotic anaphase, in cytokinesis and in organizing the spindle and the centrosome . Ubiquitination-dependent degradation at the onset of anaphase is likely to activate sep-1 resulting in the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes . Also required for cortical granule exocytosis .
Q18235
Q9BSG1
ZNF2_HUMAN
Zinc finger protein 661
Homo
MAAVSPTTRCQESVTFEDVAVVFTDEEWSRLVPIQRDLYKEVMLENYNSIVSLGLPVPQPDVIFQLKRGDKPWMVDLHGSEEREWPESVSLDWETKPEIHDASDKKSEGSLRECLGRQSPLCPKFEVHTPNGRMGTEKQSPSGETRKKSLSRDKGLRRRSALSREILTKERHQECSDCGKTFFDHSSLTRHQRTHTGEKPYDCRECGKAFSHRSSLSRHLMSHTGESPYECSVCSKAFFDRSSLTVHQRIHTGEKPFQCNECGKAFFDRSSLTRHQRIHTGESPYECHQCGKAFSQKSILTRHQLIHTGRKPYECNECGKAFYGVSSLNRHQKAHAGDPRYQCNECGKAFFDRSSLTQHQKIHTGDKPYECSECGKAFSQRCRLTRHQRVHTGEKPFECTVCGKVFSSKSSVIQHQRRYAKQGID
May be involved in transcriptional regulation.
Q9BSG1
Q4ICM9
PAM17_GIBZE
Presequence translocated-associated motor subunit PAM17, mitochondrial
Fusarium
MASPLKTFVLRMPATGLVRSSPKASFSTISAARPASCLSRSPFRKQCFKPAISINKSFSRAVSDKPQPETVQATPQPAPSNVLPPLDWNSFFKLRVKRRRYQMLFSITNGIFAGSGGAIFLSTGSAEPIISQIPLDPFMTLGLMTLAFSGLGWLSGPSVGNQVFYILNRQWKKQMTQKEAIFFERIKRNRVDPTNSSANNPVPDFYGEKISSVAGYRSWLKDQKAFNKKKTANFV
Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
Q4ICM9
Q2SL32
RNC_HAHCH
Ribonuclease III
Hahella
MTAKLERLQRALGYTFKEPALLTLALTHRSFGGRNNERLEFLGDSVLNFIIADYLFGRFEEAREGQLSRLRARMVKGVTLAEIAREFDLGEYLRLGSGEMKSGGFRRESILADALESIIGAIYLDAGFEVCADRVLNWFEARLQKLNLKDTQKDSKTRLQEYLQARQLNLPRYEVISVQGEAHAQTFHVRCEIDGLSDATEGTGSSRRVAEQKAAKQALLALGVDQ
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Q2SL32
Q7VT71
MASZ_BORPE
Malate synthase G
Bordetella
MTERIPHHGLQVAASLHRFIEDEALSGSGLAPDEFWAGFAALVRDLAPRNRELLAERDRLQGEIDAWHRAHPGPVRDSAGYQALLERIGYLQPQPAQVTASTRDVDSEIASQAGPQLVVPVSNARYALNAANARWGSLYDALYGTDAIPPVAGDDGKGYNPARGEAVIARARAFLDEAAPLAQGSHADATAYAIEGGKLVVTLGAGQRTGLRNPAQLAGYQGDASQPAAVLLANNGLHFEIQIDRQHQIGATDAAGVKDVLLEAALTTIMDCEDSVAAVDADDKVLIYRNWLGLMKGDLSESVTKGGKTFTRRLNADRQYHKPDGGTLTLHGRSLMFVRNVGHLMTNPAILDEQGSEVPEGILDAVITSLAALPDRANRLNSRTGSIYIVKPKMHGPAEAAFANELFDRVEDLLKLPRHTIKMGIMDEERRTSVNLKACIAAAAARVAFINTGFLDRTGDEMHTGMEAGPMLRKGDMKSSAWITAYERNNVLVGLDCGLRGRAQIGKGMWAMPDMMAAMLEQKIGHPKAGANTAWVPSPTAATLHAMHYHQVDVAAVQQALEQTRYDSVRDELLAGLLTVPVGDPAAWSADDIQRELDNNAQGILGYVVRWIDQGVGCSKVPDINNVGLMEDRATLRISSQHIANWLRHGIVDRAQVNATFERMAKVVDQQNAGDPNYLPMAGHFDTSFAYRAACALVFEGLTQPNGYTEPLLHEYRQAFKAARR
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
Q7VT71
Q0I8I3
HEM3_SYNS3
Pre-uroporphyrinogen synthase
unclassified Synechococcus
MALEHLRIASRRSQLAMVQTNWVKAELEKAHPGLAISVEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGRAEIAVHSLKDLPTNLPEGLMLGCITEREDPADALVVNSKNAEYTLETLPEGSIVGTSSLRRLAQLRYHYPHLQFKDVRGNVITRLEKLDSGNYDCLILAAAGLSRLGFGDRIHQSIPGNISLHAVGQGALGIECVCDRPEVMELIQVLNHAPTSARCLAERAFLRVLEGGCQVPIGVNTQIEGDTIQLTGMVASLDGKRLIRDEQAGPLADPEAVGRDLAHKLKDQGAGEILQEIFEMERGQ
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Q0I8I3
P30657
PSB7_YEAST
Proteinase YSCE subunit PRE4
Saccharomyces
MNHDPFSWGRPADSTYGAYNTQIANAGASPMVNTQQPIVTGTSVISMKYDNGVIIAADNLGSYGSLLRFNGVERLIPVGDNTVVGISGDISDMQHIERLLKDLVTENAYDNPLADAEEALEPSYIFEYLATVMYQRRSKMNPLWNAIIVAGVQSNGDQFLRYVNLLGVTYSSPTLATGFGAHMANPLLRKVVDRESDIPKTTVQVAEEAIVNAMRVLYYRDARSSRNFSLAIIDKNTGLTFKKNLQVENMKWDFAKDIKGYGTQKI
Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. PRE3 and PRE4 are necessary for the peptidyl-glutamyl-peptide-hydrolyzing activity.
P30657
Q49ZF6
RL5_STAS1
50S ribosomal protein L5
Staphylococcus
MNRLKEKFNSEVTQNLVKQFDYSSVMEVPKIEKIVVNMGVGDAVQNTKVLDDAVEELQAITGQKPLITKAKKSVATFRLREGMPIGAKVTLRGERMYDFLDKLIAVSLPRVRDFQGVSKTAFDGRGNYTLGVKEQLIFPEIDYDRVNKVRGMDIVIVTTANTDEEARELLSQFGMPFHK
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Q49ZF6
B2UDL1
UNG_RALPJ
Uracil-DNA glycosylase
Ralstonia
MTRRANPAQAALFDEPAVDAADVSFIPLAQQFDALPADWKAVLTPCIAQTNWPELCAFVDGERAAGKPIFPTDVFRALHLTSVDDVRVVILGQDPYHGTGTVDGREIPQAHGLAFSVPAGVRVPPSLRNIYKEIEAEFGCKLPGTSGNLEGWAQQGVLLLNTVLTVEQGQAASHAKRGWERITDCLLEQLARVGHKRVFMLWGSHAQAKRALLSDGHLVLEAPHPSPLSAHRGFLGCGHFKTANDWLAAQRQPTIDWLKPQAA
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
B2UDL1
B0TJA6
RS20_SHEHH
30S ribosomal protein S20
Shewanella
MANSKSAKKRALQSEKRRQHNASRSSMLRTYVKKVIAAINAGDHATATAAFAVAQPIVDRMATKGLIHKNKAARYKSRLNAKIKALVA
Binds directly to 16S ribosomal RNA.
B0TJA6
Q2RGI1
ACPS_MOOTA
4'-phosphopantetheinyl transferase AcpS
Moorella
MLEAGIDIIEISRLERSIKRHPRLLARVFTPAEVAYCLARHRPGASLAARFAAKEAVMKALGIGLGRCSWQDIEITREQGGRPRVILHNRARQLARELGVGEITVSLSHCHAYAAAVALVESSFSEEG
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
Q2RGI1
A5CQ58
ATPA_CLAM3
F-ATPase subunit alpha
Clavibacter
MAELSISPDEIRDALKDFVQSYEPGKASTTEVGYVLDAGDGIAHVQGLPGVMANELITFADGTLGLAQNLEESEIGVIVLGEFAGIEEGMEVRRTGEVLSVPVGDGYLGRVVDPLGNPIDGQGEIATEGRRALELQAPGVMQRKSVHEPMQTGIKAIDAMIPIGRGQRQLIIGDRQTGKTAIAIDTIINQKANWESGDTNKQVRCIYVAIGQKGSTIASVKGALEEAGAMEYTTIVASPASDPAGFKYLAPYTGSAIGQHWMYGGKHVLIIFDDLSKQAEAYRAVSLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDELGAGSMTGLPIIETKANDVSAYIPTNVISITDGQIFLQSDLFNANQRPAVDVGISVSRVGGDAQVKSIKKVSGTLKLELAQYRSLEAFAIFASDLDAASRRQLARGARLTELLKQPQYSPFPIEEQVVSIWAGTKGKLDEVPVEDILRFERELLDHLHRNTEVLSQLKEKNVLTDDIVDAMDKAVDQFKLEFQTGEGKPLASVGSEKFEPAKAEDVNQEQIVKGKR
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
A5CQ58
Q95XR4
EPG2_CAEEL
Ectopic P granules protein 2
Caenorhabditis
MSANRTVTVFSSSAEDQEPIELAEDSLQNLDKMLAEEKEEHQLLKDEVVLLRKENVEAKTYSTLLEIMLDEAEEKASSAQETTSEENNLKILNRDLVAENLELKEMKEELRKIWLSDSKKFQEALTRISDENTKLQKDCHELESIRQCAQFALDNCNEELEKTQTENEEHESRIETLEREVCEKDIAMKDIVERKDEISLQLELQTKEFTSALNDLMYGREDTLKQIHQMKENWKVKQNEFEVEITKLKSQNDYFDSERLQLTDRIRALLNELSDVRLELGSTRLAMKEKAEVTEAVTSFNKDLRDKLEDEIARLGECLQFRKDEHEQDEAVIAHLEEQLKLGSDKAAAFSSEHSDTIELLRESETELMELRMENYDLKEDFKILKEEKEDVNRTCECLREQLSTTIQERDIEKGQMQSEMDAKMVAVHQQYAKQIDNMKYNHMLAINQELIKGQMALESGKKKHANEILTVRNELEQSNAAHQSLRDQCSLLLSSEDDLRTAHLALESKMTLVSEECIALRVSRANAQKEIGNLTEHHKLEVALLEDAKSGIQQRLHYATIEIEQLKKINEVTQAQFKKETDEKNAEINEFQAAMVSMKQQYNVLGNHCRVLTSQGISDRTTIDKLQETIREHTELAIETKRIHDAEIVQLNDAHKKLVDNLGVEELDEEPKASTESEEKAEWEMVDEE
Involved in autophagy . Thought to act as an adapter protein that brings PGL granules to autophagic structures containing lgg-1 . Association with other adapters such as sepa-1 is required for the accumulation and degradation of germ cell specific P-granules by autophagy in somatic cells . This ensures exclusive localization of the P-granules in germ cells . May also play a role in the removal of sepa-1 from somatic cells .
Q95XR4
Q99PF6
GAB1_MESAU
Growth factor receptor bound protein 2-associated protein 1
Mesocricetus
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEDMNKWVRCICDICGFNPTEEDPVKPLGNSSQAPVDSPFAGNTAPASTQLEASPVTLPPSYQLISLPPHPDTLGLQDDPQDYLLLINCQSKKPEPTRTHADSAKPTSSETDCNDNVPSHKTPASSQSKHGVNGFFQQQMLYDCPPSRAASVSVDSSLYNLPRSYSHDVLPKESPSSTEADGQLYIFNTPSGTSSVEAQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQSSKLDTIPDIPPPRPPKPHLTHDRSPVETCGAPRTASDTDSSYCVPTAGMPPSRSNTISTVDLNKLWKDASSQDCYDIPRTFPSDRSSSLEGFHNQSKIKNVLTVASVSGEEPDENYVPMNPNSPPRQHSSSFTEPIQEPNYVPMTPGTFDFSSFGMQVPPPAHLGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKAKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPLSPRPNSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSSMIKPKGDKQVEYLDLDLDSGKSTPPRKQKNSGSGSSMADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPTKSVK
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway.
Q99PF6
Q9W603
SP16H_XENLA
Facilitates chromatin transcription complex subunit spt16
Xenopus
MAVTLDKEAYYRRIKRFFGSWKKGDDEFANVDAIVVSVGVDEEIVYAKSTALQTWLFGYELTDTIMVFCEEKILFMASKKKVEFLKQIANTKGNENANGTPAITLLVREKQNESNKGNFDKMIEAIKVSKKGKRIGVFIKDKFPGDFMKSWYDILNKESFEKVDISASVAYTIAVKEEGELNLMKKAASITSDVFSKFFKDRVMEIVDADEKVRHGKLAESVEKAIEDKKYLGGTDPSTIEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCALGIRYKSYCSNLVRTLMVDPTQEMQENYNFLLQLQEELLKELKHGAKICDAYQVIMDQVKKQKPDLMSKITKTLGFAMGIEFREGSLVINNKNQYKLKKGMVFSVHLGLAELNNKMGKKPEEKTYALFVGDTVLVNEEGAATVLTNVKKKVKNVGIFLKKEDEEEEEEEKDEAEDLLGRGSRAAALLTERTRNEMTAEEKRRTHQKELATQLNDEAKRRLTEQKGGQQTMKARKSNVSYKNASQVPKEPELREMKLYIDKKYETVIMPVFGISTPFHIATIKNISMSVEGDYTYLRINFFCPGSALGRNEGNIFPNPEATFVKEITYRASNVKTPGDPSVPSLNLQNAFRIIKEVQKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTSVRGDKVDILYNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKKRHTDVQFYTEVGEITTDLGKHQHMHDRDDLYAEQLEREMRHKLKTAFKNFIEKVESLTKEDLEFEIPFRDLGFNGAPYRSTCLLQPTSSSLVNTTEWPPFVVTLDEVELVHFERVQFHLKNFDMVIVYKEYGKKVTMINAIPMASLDPIKEWLNSCDIKYTEGVQSLNWTKIMKTIVDDPEGFFEQGGWSFLEPDGEGSDAAEGDSESELDDETFNPSEDEEEEEEDSDEDYSDETEDSVDSEESADSEEESGKDWDELEEEARKADRESLYEEVEEQKSGNRKRKGHAPLPNPSKKRKK
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.
Q9W603
Q42609
PALY_BROFI
Phenylalanine ammonia-lyase
Bromheadia
MEVSKENGLCLQGRDPLNWGAAAAELQGSHLDEVKKMVEEFRRPVVKLEGVKLKISQVAAVAFGGGASAVELAESARAGVKASSDWVLESVDKGTDSYGVTTGFGATSHRRTKQGGALQKELIKFLNAGIFGSGNSNTLPSAATRAAMLVRINTLLQGYSGIRFEILKAIATLLNKNITPCLPLRGTITASGDLVPLSYLAGILTGRPNSKARTPNGSTVDATTAFRLAGISSGFFDLQPKEGLALVNGTAVGSGVASIVLFETNILAVMAELLSALFCEVMQGKPEFTDHLTHKLKHHPGQIEAAAVMEHILEGSSYMKMAKKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRAATKSIEREINSVNDNPLIDVSRNKALHGGNFQGTPIGVSMDNTRLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSSGRNPSLDYGFKGAEIAMASYCSELQALANPVTNHVQSAEQHNQDVNSLGLISSRKTAEAVDILKLMSTTFLVGLCQAVDLRHLEENLKNAVKNTVSQVAKRVLTMGVNGELHPSRFCEKDLIKVIDREYVFAYADDPCSSTYPLMQKLRAVIVEHALNNGVKEKDSNTSIFQKISSFENELKAALPKEVEAARAEFENGSPAIENRIKDCRSYPLYKFVKEVGSGFLTGEKVVSPGEEFDKVFNAICEGKAIDPMLDCLKEWNGAPLPIC
This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.
Q42609
Q6LY53
THIM_METMP
4-methyl-5-beta-hydroxyethylthiazole kinase
Methanococcus
MDFVAKNLTKLRETNPLVQNITNYVVMNSTANSLLALGASPVMAHAMDELEEMVSIASALVVNIGTLDEYWIPSMEKAAKIASDLKKPIVLDPVGAGATKLRTKTALKILDFADISVLRGNFGEIAAVLGEHGKTRGVDSAAYDSNEAIELSKNAAKEFNTVSAVTGPVDHVSNGKEIYSISNGHSMLSKVTGTGCATTSIIGAFSAVDDPLKAAVSGLVVYGISAEMAFTEAPYPGTFQAKVYDWLYRIDEKLVLEKAKVNKFEI
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
Q6LY53
A0A0A1I6E7
NDB4S_ANDCR
Antimicrobial peptide AcrAP1
Androctonus
MEIKYLLTVFLVLLIVSDHCQAFLFSLIPHAISGLISAFKGRRKRDLDGQIDRFRNFRKRDAELEELLSKLPIY
Has antimicrobial activity against the Gram-positive bacteria S.aureus (MIC=8 uM) and the yeast C.albicans (MIC=16 uM). Causes hemolysis on horse erythrocytes (64 uM for 100% hemolysis). Minimum bactericidal concentrations have also been tested against S.aureus and is four-fold higher (MBC=32 uM).
A0A0A1I6E7
B2GV47
RADX_RAT
RPA-related protein RADX
Rattus
MSGESDQPQPGPSHAGLYLEHRERDQAGVPGGVIRRAGSQRHRSWIQTVIEQITGSPRQCVTLSEVVPVSVLAVQRYLLEDEPRDTVPKPPLYCYDVTISDGVYQEKCYLDPSLNFLVYQNILKVGIEMRISRVSCLYNEKRLGQGILCIDKVHCGEPLDVISVETPFRNRAHEEKPERPLRGSKSHYLALWNNEDPYGDIWKTNKQPEEFNFNNTKIISLSHLEMTWHNRKNFPALLVRILHKSKLRYYGKPNKKMIEPYQTYLEVADSSGMVSVIMWNALCPEWYKSLRVGLILLLQDYSVKKSYPLRIQPDPVDPQMKLISTMEICLNLRDPPTNIVIIPEKQLKSEWKLPKLINRFITRSELDDMPENSICDVIGMLSFVGRVQRSKKKENSEDFWSYRWIHITDGTSEQPFIVQLFSTSQPEVFENIYPMTYFVCTQLKVVRNNSQVPKLLYLTTTNESRVLITGHRGQPYTYDTKAKKIIQWIKTKTNLEAKNTVIGGYYPYPPVPETFSKYSRFIKAESLLTTISEVRKVIEDLQYREQKRIAIQGIITAIKYIPYNHSAKSAPASETLQNASPPSTSQAAAKEGHYHERGSKRSQDDRPMDSLPMVLSLCAKRKILQGPTANPVPVPQPHSSAQMKGNKPNIPSRENSTANATGKSKRIINDRWESQLWRDKKFSLRDHLHYGHVDPESIPRKFILGHEKFLTQQFNSQPAKYVPPEGKPPKLDEFQSARSLGHFEVTILGLNHEIAIDVAFLPMYSPEDVETSQIDTFLTCMNYSCVYPPAAPVSGRVPDPKAVAGDIVKAAADLDRVHIIGILDICNLGNNKVEVCLQKIYTPE
Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks.
B2GV47
Q8D4T9
NAGB_VIBVU
Glucosamine-6-phosphate isomerase
Vibrio
MRLIPLKTAAQVGKWAAAHIAKRINDFQPTAERPFVLGLPTGGTPLATYKALIELYQEGKVSFKHVVTFNMDEYVGISADHPESYRSFMYNNFFNHIDIQEENINLLNGNAEDHEAECQRYEDKIKSYGRINLFMGGVGNDGHIAFNEPASSLSSRTRIKTLTEDTRIANSRFFDGDINQVPKYALTIGVGTLLDSQEIMILVTGHNKALALEAAVEGSVNHLWTVSALQLHPKSVIVCDEPSTQELKVKTVKYFTELEAKNIVGF
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Q8D4T9
Q7YC63
CYB_APOMU
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Apomys
MTNIRKTHPLIKIINHSFIDLPAPSNISSWWNFGSLLGLCLMIQIITGLFLAMHYTSDTTTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFIHIGRGMYYGSYTFMETWNIGVILLFAIMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIIAALVIVHLLFLHETGSNNPTGLNSNADKIPFHPYYTIKDLLGVFMLILFLMTLVLFFPDMLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAFLPFLHTSKQRSLMFRPITQVLYWMLVANLLILTWIGGQPVEHPFIIIGQLASISYFSIILILMPISGIIEDKLLKWSL
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q7YC63
Q8YDR8
Y3107_BRUME
Probable ABC transporter permease protein BMEII0107
Brucella
MNARLTGLGLNLLSFAVGIGGWYLLTATGAVVLPGPVDVLERAVTLLLNGQLVGDIFASLRRVLSGFVLGVALAIPVGFLMGWYRIARSLIEPWVQFFRMIPPLAVIPLAIVTLGIDESPKIFVIFLASFLSSVVATYQGVISVDRTLINAARVLGAKDATIFARVIVPASVPFILVGVRIGLGSAWATVVAAELIAAQSGLGYRMQQAQLYYDLPTIFVSLVTIGILGLFMDRLLQAADRRLTQW
Probably part of an ABC transporter complex. Probably responsible for the translocation of the substrate across the membrane (Probable).
Q8YDR8
Q8HXE3
KMCP1_MACFA
Solute carrier family 25 member 30
Macaca
MSALNWKPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALYSGIAPAMLRQSSYGTIKIGTYQSLKRLFVERPEDETLLINVICGILSGVISSTIANPTDVLKIRMQAQSSTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRVLQDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIILFVTYEQLKKLDL
Probable transporter.
Q8HXE3
A4WKJ7
GCH3_PYRAR
GTP cyclohydrolase III
Pyrobaculum
MHKVVLISLRGYREWTESLGPRREHIIQKVQARIHGALWSSFTAVGALPHHFRYDYLIALANNVPRHWIDTAVAKIRRSSPVEVDYCIGMGETPLDAYRSCGEHKEGKESNAVVAHVDIVNSTDATRINGPIHTYLRALDMLRTAAGACEDVGCIAFYLGGDNMVVYLPEPKAIYALLDRVEAPVRAGVGVSPRPYTAFVKATKGLDALRAENKTGVKVVR
Catalyzes the formation of 2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity.
A4WKJ7
B2U822
RNPA_RALPJ
Protein C5
Ralstonia
MGLHAYPKAARLTKTDEFSSVFALRPVRRSRHFVLYVRANGDRPARLGVVIGKKFAKRAVERNLIKRQCRELFRLRQPLLGGRDVLIRLQAKFPRQDVPTVAAFKRICREELAQLFEVATRPLSAPPAATPPQPTAGSTP
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
B2U822
Q8CPP8
QOX3_STAES
Quinol oxidase polypeptide III
Staphylococcus
MSHDANTIDSRTHEGELNKLGFWIFLTAEFALFGTLFATLLTLQHGGGYGGKLTTDLFELHLILIMTFALLISSYTCGIAIYYMRQEKQNLMMFWMIITVILGLVFVGFEIYEFAHYASEGVNPTIGSFWSSFFILLGTHGAHVSLGIVWVICLLIQIGTRGLDSYNAPKLFIVSLYWHFLDVVWVFIFTAVYMIGMVYSG
Catalyzes quinol oxidation with the concomitant reduction of oxygen to water.
Q8CPP8
Q8D3D5
OPGH_WIGBR
Glucans biosynthesis glucosyltransferase H
Wigglesworthia
MTNNKNYMKFLKFYNKKNKIKKIKNCSYKKLFCMNHYLRTGSNKRKKFLKKQYISTISVKKRLKCAWPKLINCSNFIIKDKKNIPLIKSYPKINRTSIAPTPWVIDSIFSFLKKFFFKKQNSKILSKNKKKKYLEKWEIVGIIRRYVFLILILSQTSIATYKLNSILPYKDISWSYTIYLFNKNIFLIIKYFSPYILQIFVLILFYILFFWVSASFWTAFMGFYQLITKKDEYNISNKSIVKEIKKNHRTAILMPICNEDVERVFAGLRATYESILSTGKIKFFDIYILSDSYNTDICMSEQKSWIDLCSETGFIGNIFYRRRNRRVKQKSGNIDDFCRRWGKNYSYMVILDADSIMSGKCLVKLVSLMESNPRAGIIQSIPKASGMNTLYARYHQFSTRVYGPLFTAGMHFWQLGESHYWGHNAIIRIKPFIKYCVLSPLPGNGIFSGSILSHDFVEAALMRRAGWSVWIAYDIPGSYEEPPPNLLDELKRDRRWCHGNLMNFRLFFMNGLHPVHRVVFLTGVMSYLSAPLWFAFLILSTILQIIYNIEFMCCFKINSYFYIIPYLHLEASIGLFFITLLLLLLPKFFSVILIISKNSIQYGGTRCFILSIILEIFLSMMFSPIKMMFHTFFIFRAFFGFSLSWKSPKRRDFSTSWKESIKSHIVQVVIGLIWSFLIIFFMTIKSLFIFFPIIFSLIISPLISVYSSYVKIGLIFKNFGLLLIPEEKYPPKEIINTKKYFKINKNKSLKNGFFQAILHPVYNALAVAMASSRHNSSILIDLNRKKFLDLILIKGLNKLNMIEKLTVLNDPIILTKLHFIYLLNNQ
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
Q8D3D5
A6WRA3
TORD_SHEB8
Chaperone protein TorD
Shewanella
MSQVDINHARALVYQLLSSLFAREVDEQRLKELTSEAAQQFWEQLSLEAKLTQSVDKIRSTLNGIKDDETLLELAADYCGLFLVGTKHSASPYASLYLSGEDEPLLFGQQHQQMSEFLHQSKLQVQSHFPEPADHLAVMLAYMAHLCCHSEDSVQLSFLQTCVDSWLAKFINQLTQCDKNGFYSAVAILTLAWVKQDIAQLEPAEAVIS
Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
A6WRA3
Q0P5F9
AL8A1_BOVIN
Aldehyde dehydrogenase family 8 member A1
Bos
MAGRGGLLMLENFIGGKFLPCSSYLDSYDPSTGEVYCHVPNSGKEEIEAAVEAARAAFPGWSSRSPQERSQVLQRLADLLEQSLEELAQAESKDQGKTITLARTMDIPRAVHNFRFFASSILHHTSECTQMDHLGCLHYTVRAPVGIAALISPWNLPLYLLTWKIAPAIAAGNTVIAKPSELTSVTAWMMCRLLEKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERIMQLSAPHCKKLSLELGGKNPAVIFEDANLAECIPTTVRSSFANQGEICLCTSRIFVQRSIYSEFLKRFVEAARMWKVGIPSDPSADMGALISKAHLEKVRSYIKKARMEGAQILCGEGVDKLNLPPRNQAGYFMLPTVITDVKDESCCMKEEIFGPVTCVVPFDSEEEVIQRANNVKYGLAATVWSGNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGVGREGAKDSYEFFTEVKTITVKH
Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation.
Q0P5F9
Q5TIS6
NOTO_MOUSE
Homeobox protein notochord
Mus
MSSPAPSGTQVQPGSLRPCPGAVSPVVPRRLARGRLESSFSVEAILARPKTRELAATSLPLSTCTSLNLLGAVSQYGVLPWVCSTGSWLPAYLSVGVYPLCSMSCVPGLNVTHHQQGLRLTGSELPYCLGPLKWAPTVDLRDHGTERHTKRVRTTFNLQQLQELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQNRRVKYQKQQKLKLPSSSVMEEPSSSSDGNIQSEDAELGIGS
Transcription factor that controls node morphogenesis . Acts downstream of both FOXA2 and Brachyury (T) during notochord development . Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function . Plays a role in regulating axial versus paraxial cell fate . Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node .
Q5TIS6
P47660
UVRA_MYCGE
Excinuclease ABC subunit A
Mycoplasma
MKPEWKNNDFIRVKGARENNLKNINIDIPKNQFVVITGLSGSGKSSLAFNTIYAEGRRRYLESLSSYARQFLGNSDKPDVDLIEGLSPAISIDQKTTSHNPRSTMGTVTEIYDYLRLLWARIGTPYCPNGHGSIQTQTINQIANQIFDLPNKSKVQLLAPTVKNQRGIFTNEFIKYKQLGFLRVLVDGQIYTLDDEIKLDKNTKHNISVVIDRIIINKDNQTYSRIVDSIETIDRLTNGKIEVLKEDGTILNFSKNHGCDKCGFSISELEPRLFSFNSPLGSCSYCKGLGFSYEPDVDKIIADSKLSINQGAIDIFKNIVHGTSLDWQRFLSLVNHYKIPLDKPIEQLDKSQLNLILEGSDEPIEIKTISNSGAKNIRFEHYEGIANLIKRRHLETNSQVSREWYSAYMSEITCKKCHGKKLIKDALSVKLGGIDIISFTELSIDKSIDFLLKLELNDEQKKIGELALKEIINRLSFLKNVGLDYLNLARRASTLSGGEAQRIRLATQIGSQLTGVLYVMDEPSIGLHQKDNMRLIKTMMVMRDLGNTLLVVEHDSETMLAADYLIDIGPKAGNEGGELVACGTPLQVMENSNSITGQYLSGKKQISIPKNRHSGNGKTIIIKGAKVNNLKNINVTIPLNKLVLITGVSGSGKSSLINQTLVPALERILYRKGVKKDTYKEIIGANNIDKIIVVSQDPIGRTPRSNPATYISVFDDIRDLFANTKEAKARGYTNSRFSFNVPGGRCDKCFGDGVIRIEMHFLPDVYVKCEVCNGKKYNSQTLEIKYLGKSIFDVLQMSCKEAYEFFKAIPNISRKLRLLCDVGLEYLQLGINVTFLSGGEAQRIKLSKFLQKKSTGKTLFVLDEPSTGLHLEDINKLLTIIQRIIKNGDTVVVIEHNLDIIKVADYIIDLGPEGGDNGGQIVAQGTPEQLINQVNKSYTAQYLSKILKPDSI
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
P47660
Q13DU3
RIMM_RHOPS
Ribosome maturation factor RimM
Rhodopseudomonas
MPAGLICIARIGAPHGVRGAMRLWSFTAEPLAVMDYGPLATKDGARSFEIATARPAKDHLVVTLKGVATREEAERLNGLELYVPRDRLPPTEDGEYYHADLIGLPAITPAGEPLGRVLAIHNFGAGDIIEIAPPQGATLLLPFTNAVVPTVDLTAGHVVIELPTEIEGDTPNHPEA
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.
Q13DU3
Q2RH55
GLGA_MOOTA
Starch [bacterial glycogen] synthase
Moorella
MNKPLKILLVSPEVAPLAKTGGLADVAGSLPKALAAKGHEVRVAMPRYRQVKEVNYLTDLPVEMDGSLETAVIRQGKLPGEAGIPVYLIDNYKFFYRDGMYGYGDDAARFNFFCKAVLSMLPWLEFQPDIIHCNDWQTGPIPLFLKVKHEDNPFYRETATIYTIHNLQYQGTFPRNILKTMALSEEFFVPERLEFYGQVSYMKAGILYADLVNTVSKKYALEIQTPEYGERLDGLLRKRAADLRGILNGIDYEEFDPATDRRLAVNYDADHLEKKGENKAALQREMELPVRDVPVLGLISRLVSQKGLDLLAAILDPLMQQDLQFVLLGSGEDYYQQLFSRYKVKYRDKMAVKIGFDPVLAQHIYAGCDIFLMPSRFEPCGLGQMISLRYGAVPVVRATGGLEDTIKDLHQYPGVGNGFTFRDYQPQALLDTINRALHVYRHEPGEWRKLMRRGMAADFSWSASAGHYEEMYREALEKRRAAMFKVG
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
Q2RH55
A2Z259
ZHD1_ORYSI
Zinc-finger homeodomain protein 1
Oryza sativa
MDFDDHDDGDEEMPPMPVSSSYETPPQHGLAGGGMAPKPPGEIGSHVKGPSCGGGRYRECLKNHAVGIGGHAVDGCGEFMAAGEEGTIDALRCAACNCHRNFHRKESESLAGEGSPFSPAAVVPYGATPHHQFSPYYRTPAGYLHHHQHHMAAAAAAAAAAAGGHPQRPLALPSTSHSGRDDGDDLSGMVGPMSAVGPLSGMSLGAGPSGSGSGKKRFRTKFTQEQKDKMLAFAERVGWRIQKHDEAAVQQFCDEVGVKRHVLKVWMHNNKHTLGKKLP
Putative transcription factor.
A2Z259
Q9RV39
AATNT_DEIRA
A-adding enzyme
Deinococcus
MFRRRPPLPPFPPGAALVGGAVRDWLRGVRSADYDWAHPDPAAGARALAALVGGAAFPLDEERGYWRVTAGEVQHDFVPLPPNLEDDLRRRDFTVNAIALREGRRLVDPLGGQQDLKRRVLRMVSEDNLRADPLRAWRAARFVTTLSFTLEPQTEQAVRQVAADLKAGRLPFPAWERVRDELHALLRSPDAARGILTLEALGLLDLTLPELREGQGLTQGGFHHLDVFEHGVEALHQLLTRRPDADLLLRWATLLHDVGKPRTFARDPDTGRRSFHGHDRVGAELTTQILTRLKLPGADVKRAAALVKAHMVQLPADDAQARRFVHRRRELLPDLLSLMLADREAARGPSSSELGRFAYMLAMERVLAALEEQPAAPPPLLSGKEVMALLGLTPGPRVGEVLRALAEARALGEVGTPQEARAFVQRWAEETPGS
tRNA nucleotidyltransferase involved in the synthesis of the tRNA CCA terminus. Adds the terminal adenosine residue to tRNA.
Q9RV39
A6QB69
PROB_SULNB
Gamma-glutamyl kinase
unclassified Sulfurovum
MKRIVIKVGSHVLTEDGSIARERMMALVELIADLKKHSYEVALVSSGAVAAGYTQLPLDRDDIANRQALAAIGQPLLLKMYQEKFARFDLLCSQVLFSADVFESDKHVSHAKVAIDTLLANNVVPIINENDTVSIEELVFGDNDRLSAHVAHYFDADLLVILSDIDALYDKDPNCFQDARRRAVVNEIEEEELAAEHTPNNEFATGGIVTKLQAADFLMKHGREMFLASGFELSDVKSFLIEGEHKGGTLFTSTKRS
Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
A6QB69
P72392
FABH1_STRCO
3-oxoacyl-[acyl-carrier-protein] synthase III 1
Streptomyces albidoflavus group
MSKIKPSKGAPYARILGVGGYRPTRVVPNEVILEKIDSSDEWIRSRSGIETRHWAGPEETVAAMSVEASGKALADAGIDASRIGAVVVSTVSHFSQTPAIATEIADRLGTDKAAAFDISAGCAGFGYGLTLAKGMVVEGSAEYVLVIGVERLSDLTDLEDRATAFLFGDGAGAVVVGPSQEPAIGPTVWGSEGDKAETIKQTVSWDRFRIGDVSELPLDSEGNVKFPAITQEGQAVFRWAVFEMAKVAQQALDAAGISPDDLDVFIPHQANVRIIDSMVKTLKLPEHVTVARDIRTTGNTSAASIPLAMERLLATGDARSGDTALVIGFGAGLVYAATVVTLP
Essential enzyme that catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain of fatty acids.
P72392
B1LWQ2
RS13_METRJ
30S ribosomal protein S13
Methylobacterium
MARIAGVNIPTNKRVVIALQYIHGIGAKKAEEITQKVNIPAERRVNQLTDAEVLQIRETIDRDYLVEGDLRREVSMNIKRLMDLGAYRGLRHRKQLPVRGQRTHTNARTRKGKAKPIAGKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
B1LWQ2
Q09G14
RPOA_PLAOC
Plastid-encoded RNA polymerase subunit alpha
Platanus
MVREKVTVSTRTLQWKCVESRADSKRLYYGRFILSPLIKGQADTIGIAMRRALLGEIEGTCITRAKSEKIPHEYSTIVGIEESVHEILMNLKEIVLRSNLYGTRNASICIRGPGYVTAQDIISPPSVETVDNTQHIANLTEPIDFCIELEIERNRGYRMKTPNNSQDGSYPIDAVFMPVRNANHSIHSYANGNEKQEILFLEIWTNGSLTPKEALHEASRNLIDLFIPFLHAQEENILLEDNQNGVTLPFFTFHDRLAKIRKNEKEIALKYIFIDQSELPPRTYNCLKRSNIHTLLDLFNNSQEDLMKIEDFRIEDVKQILGILQKHFTVDLPKNKF
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q09G14
Q477Z0
ATPE_DECAR
F-ATPase epsilon subunit
Dechloromonas
MAMTVHCDVVSAEESIFSGLVEIAVFPGEAGELGILPRHTPLLTRIKPGTIRLKVPDQSEFELVYVSGGMLEVQPDMITVLADTAIRAHDLDEAKALEAKKRAEEALANRNAEMDYAAAEAELAQAVAQLQAIQRLRKHTH
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q477Z0
Q8MEY4
MATK_CERME
Intron maturase
Ceratozamia
MDKLQRDGKEDTSRQRRFLYLLLFQEDLYAIAYDHYFNRSSSFEPMENSSSNDRFSFLTVKRSISRIRQQNGSIIPFVNCDQNRLVGHSRSFYSELVLGGLTAVPEVPFSIRSKHSLEGMNEWTSFRSINSIFPLMEDKIPHSNFLLDIQIPHLTHPEILVRTFRRWIQDAPFLNLLRSVLHEHRNLTISSNLDQLILIASKENKRLSLFLWNYYAYECESLLVPLWKRFSHSRSLPYESFIERTPFYQKIKNIVIFYHKYIKKSLWFLKDPSIHYVKYRERSIIALRGTYLLVKKWRYHLTNFWQCHFHLWLQPYRIYIDEFSNNCFSLLGYLLSVKMKTSVVRIRMLDDSFITHLITKEFDPIAPTTLLIRSLAKERFCDISGHPISRLAWTGLTDDDILDRFDRIWRNIFHYHSGSSKKDGLYRMKYILRLPCAKTLACKHKSTIRVVRERFGSELFTKSFPKERESILLPFSKTRSQRERIWHSDIIQRNPLVNS
Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Q8MEY4
A1KUN6
AROA_NEIMF
5-enolpyruvylshikimate-3-phosphate synthase
Neisseria
MTESVRLPVARLKPSTVALPGSKSISNRTLLLAALSDNACEIHSLLKSDDTDRMLEALDKLGVQIEYLAEDRLKVHGTGGRFPNRTADLFLGNAGTAFRPLTAALAVLGGDYHLHGVPRMHERPIGDLADALRIAGADVEYLGKEHYPPLHIGKRQDNGERVIPIKGNVSSQFLTALLMALPLTGQAFEIRMVGELISKPYIDITLKLMAQFGVQVANENYRVFKIPADAHYHAPEHLHVEGDASSASYFLAAGLIAATPVRVTGIGANSIQGDVAFARELEKIGADVVWGENFVEVSRPKERAVQSFDLDANHIPDAAMTLAIVALATGQTCTLRNIGSWRVKETDRIAAMANELRKLGAKVVEEAEAIHITPPKTLTPDAVIDTYDDHRMAMCFSLVSLLGVPVVINDPKCTHKTFPTYFDVFSSLTETTE
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
A1KUN6
Q5E7T0
FETP_ALIF1
Probable Fe(2+)-trafficking protein
Aliivibrio
MSRTVFCVRLNKEADGLDFQLYPGELGKRIFDNISKEAWGQWQHKQTMLINEKKLNMMDPEHRKLLETEMEGFLFDGKDVVIDGYTPPSE
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
Q5E7T0
Q839F3
RL24_ENTFA
50S ribosomal protein L24
Enterococcus
MFVKKGDKVKVITGKDKNKEGVVLAAFPKQDKVIVEGVNVVKKHQKPNQAAPQGGILEVEAPIHVSNVMVIDPSNGEATKVAFKEVDGKKVRVSKKTGEVLDK
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Q839F3
Q63DX8
LEU1_BACCZ
Alpha-isopropylmalate synthase
Bacillus cereus group
MKKILFMDTTLRDGEQSPGVNLNEQEKLQIARQLERLGIHVMEAGFAAASEGDFQSVKRIANTIQNATVMSLARAKESDIRRAYEAVKGAVSPRLHVFLATSDIHMKYKLCMSKEDVLDSIYRSVTLGKSLFPTVQFSAEDATRTARDFLAEAVEVAIRAGANVINIPDTVGYTNPEEYYSLFKYLQESVPSYEKAIFSCHCHDDLGMAVANSLAAVEGGALQVEGTINGIGERAGNAALEEVAVALHIRKDFYKAEPSMTLKEIKATSTLVSRLTGMVVPKNKAIVGANAFAHESGIHQDGVLKEVTTYEIIEPALVGESQNLFVLGKHSGRHAFTEKMKELGYEFTNDERDAVFEAFKKLADRKKEITEEDLRALMLGEAAFAAQQYNITQLQVHFVSNSTQCATVVLKDEEGNVFEDAATGSGSIEAIYNAIQRILGLECELADYRIQSITQGQDALAHVHVELKEGAHQVSGFGVAQDVLEASARAYVHAAGKLKSFIQLVK
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Q63DX8
A5DIR3
PLPL_PICGU
Patatin-like phospholipase domain-containing protein PGUG_03164
Meyerozyma
MTSSTPLYDENEDYIDENHINTFAKALLWEDDDHDGLASPPLPAYEGDKLAEVNAEELSSVLTPEPNNESEKSRPEFVVSHNDWYPINAPEKSKAKADAKGRKKRASTRDEFRSSAAYTLLRWPFLIIITVWILLLCILYTVVRAYVALSEYMLTWVGERKVLRNKLRASKTYEEWIENALELDRYLHLDKWSSIPRFSYYDYRTVKRTTSKLRMLRMRGMDEELMVFLQGCLKKNFAGIENRQLYAHRYYGTKNVVHVYIDEVVASIDHVTESENITPEDKRRFFRSVSRNYGRTALCLSGGACFAYTHFGIVKALLDNDLLPSIITGTSGGGLVAALACTRTDDELKQLLVPRLARKITACEDPWYVWIPRWWRTGARFDSTAWARKSNYFTLGSLTFQEAYHRTGRRLNISTVPADPHSPVILCNNITAPNCIIWSCLLASSAVPGILNPVVLMMKDSKKNTIVPFSLGSKWKDGSLRTDIPIDALKTYYNVNFTVVSQVNPHISLFFFAPKGSVGRPVASSRRKTRREKYASLRGGFIATALEHLFKLEIKKWLEMIKTLDLLPRLSESDWSSIWLQRFTGSITIWPRNNFRDFWYILSDPSEEGLGEMIRKGERYMFPKILFLKHRLSIENAIERGRTKSKLSTAHLEHSPRFSGTPEFAGPEFQLQTVHYDDDYDSESSAEETLSPGFSQGTHAVLTDESDDDSSDDEIDD
Probable lipid hydrolase.
A5DIR3
Q1LQG2
HLDD_CUPMC
ADP-L-glycero-beta-D-manno-heptose-6-epimerase
Cupriavidus
MTIIVTGAAGFIGSNIVKGLNERGETNIIAVDNLTRAEKFNNLVDCEIADYLDKTDFVARFARGDFGNVRAVFHEGACSDTMETDGRYMMENNYRYTLALLEACLEQGAQFLYASSAATYGASTMFREDRDYEKPLNVYGYSKFLFDQVVRRRLPSAHSQIVGFRYFNVYGPREFHKGRMASVAFHHFNQFRAEGTVKLFGEYNGYAPGTQSRDFVSVEDVVKVNLYFLDHPEKSGIFNLGTGRSQPFNDIAVSVVNALRESEGKPALSLDEMVQEGLVEYVKFPDALRGKYQCFTQSDVSRLRGAGYSDQFLTVQEGVSRYCKWLLERSA
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Q1LQG2
Q9U6L5
PEB1_DROME
PEB-me
Sophophora
MVRQLILVLSLILFCGSSHAVVSELARQSESAIQGLADIKMAPLRYLDVLFGGNPGGLRGLDGGNSASLSTLQAAKVANILARGDIASSGYSKISAGVGKGSDLITIIKNTRSYDPYLIPPGIPGYNYPLGWPLRYPLGPYWPNRPPWLPINSPPIRPGGLFPGGPSPGGPSPGEPSPGEPSPGGPSPGGPSPGGPSPGGPSPGGPSPGGPSPGGPFPGGSPPSPGGPLGPWQFPWILGGPRPNRPGRPFPGGILPGHLDGSVVPNSVLNVAGGIFGNGGLFGTGIFGQHGLFGTGFLSGPSLDPFGIFTPIGNFFGSLGNLFGFSSPSQIIPIFGGKFGPLGRGLQGSITLDVGGTVPSVKGILGQLLHPFLGFLG
Major protein component of the posterior mating plug. Accessory gland proteins constitute, or are required for formation of the anterior mating plug. Posterior mating plug forms before sperm transfer and the anterior mating plug is formed after the start of mating.
Q9U6L5
A4K2W7
WFDC5_AOTNA
WAP four-disulfide core domain protein 5
Aotus
MRIQSLLLLGALLAVGSQPPAAFGRKKGEKPGACPPDDGPCLLSVPDQCMEDRQCPLTRKCCYRACFRQCVPRVSVKLGSCPEDQLRCLSPMNHLCHKDADCSGKKRCCSSACGRDCRDPVRG
Putative acid-stable proteinase inhibitor.
A4K2W7
O13935
TRM4B_SCHPO
tRNA (cytosine-5-)-methyltransferase trm4b
Schizosaccharomyces
MGKRNKKVTQGKRAYNDKSEIVLENKQFEGYYKKQNLFRGKPNDEFDSFMEYMRKPLPTTFRICGYRHHAFELKNHFEKYYVPSLKNVVHEGQTIPPPTVLPWYPDGLAYIVDAQKDVIRKSPPLKRLQRFLVSENEAGNINRQEAVSMLPPLFLDVEPHHVILDMCAAPGSKTAQLIEAVYKKANIKDAAHDSKNLKSVEGLVIANDADPKRAQMLVHQINRLNSPNILVVNHDASTMPNIYVKGSSPSDGLNVIEEKKILKFDRILADVPCSGDGTFRKNLSLWREWSANSAFSLHPLQLRILIRGLQLLKVGGCLVYSTCSINPIENEAVVTAALKATGGAVSLVDVSKKLPLLKRDPGLLSWKVLDDSLNEFQSPAENTNDKIELTESMWPLPEEEMSKLHIERCARLYPHMQNTGGFFVAVLQKTDPINSRSFDPKKYTASMEILPPENKRQRTEKGVDEASNSTLTKSGNSYFDEEPFVYINPDDTSIKTIVDFYGIDPSFPRDQFFVRNQSGIPVRSIYFACSLFKEIIEANTNRVKFVHGGVRFFVKQEISQLLKDFSLKANKDICNFRIHSNGVNIISPFLNEKHFYDAGLKDLKILVKNEYPHVEQFSESGMLKKEFEKMPLGCNILRVDAQTKDGALMDMLILQPIWRSPTSCNLMLARKEKQNLSLELFGMDV
tRNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in tRNAs at position 49 and 50 . Trm4a and trm4b methylate different sets of tRNAs . Also methylates cytosine to m5C at positions (60, 61 and 62) in tRNA(Asp) .
O13935
B4UMK8
RNH_ANASK
Ribonuclease H
unclassified Anaeromyxobacter
MSQARFIAFSDGSALVNPGGPGGTGFVVLDRARPAYRFGGTRWVEDGPNAVTNNRMELRAVLEALEGLPGGEQVEVISDSRYVVDALSRWIHGWRKKGWRTASGEPVLNRDLIEALDARASALSVRYTWVRGHDGHAVNEVVDQLAQAAARGVAGPGEAEVVAALRAEAFLAGGPAAPRSSRA
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
B4UMK8
A1VYF1
GPMI_CAMJJ
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Campylobacter
MKQKCVLIITDGIGYNKNSKFNAFEAAKKPSYEKLFKEVPNSLLKTSGLAVGLPEGQMGNSEVGHMCIGSGRIIYQNLVRINKAIENKELEKNENLQKLLAKCKRVHIIGLYSDGGVHSMDTHFKAMLEICAKNGNEVFAHAITDGRDVNPKSGLNFIKDLKEFCENLGVHFATLCGRFYAMDRDKRWDRVKECYECLLGKAYKVPNLLEYLQKSYDENVTDEFIKAVQNENYKGMREEDGIIFINFRNDRMKQLVEVLNSKDFKEFEREKIFENLLTMSVYDDKFKLPVLFEKEKIENTLAQVISKAGLSQLHTAETEKYAHVTFFFNGGKEELLENETRVLIPSPKVKTYDEKPQMSAFEVCDAVKKGIEKGEDFIVVNFANGDMVGHTGDFNAAIKAVEAVDTCLGEIVECAKKHDYAFIITSDHGNCEAMQDEKGNLLTNHTTFDVFVFVQAKGVSKIKDNMGLSNIAASVLKILDLEIPKEMNEALF
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
A1VYF1
P56368
RK23_CHLVU
50S ribosomal protein L23, chloroplastic
Chlorella
MMLDLVKYPVIRTEKTTRLVENNQLSFDVDVRITKPQIRKIIEEFFNVKVLAVNTHRPPRKTNRLGSKPSYKRVIVTVDSDVTLLK
Binds to 23S rRNA.
P56368
Q830Q6
RL1_ENTFA
50S ribosomal protein L1
Enterococcus
MAKKSKKMQEALKKVDATKAYSVEEAVALAKDTNIAKFDATVEVAYKLNVDPKKADQQIRGAVVLPNGTGKTQTVLVFAKGEKAKEAEAAGADFVGDDDMVAKIQGGWFDFDVVVATPDMMATVGKLGRVLGPKGLMPNPKTGTVTMDVTKAVEEVKAGKVTYRVDKAGNIHVPIGKVSFDNEKLVENFNTINDVLLKAKPSTAKGQYIKNISVTTTFGPGIHVDQASF
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
Q830Q6
Q8PFX6
QUEF_XANAC
PreQ(0) reductase
Xanthomonas
MNTPEDSTLGREVAYPSGYDPSLLFPIPRAAGRQAIGLTGDLPFIGRDRWHAYELSWLDAQGKPCVATATLHVPCDSPSLIESKSLKLYLNSLNATRFNSAEAVRTRIATDLSTRAGADVAVEFGLPPIDAVGEGESIDALDLSIDDYGPPNAAYLCAHAQPVVEEVLTSALLKSNCPVTGQPDWASVTLRYRGAPIDREGLLRYLVSFRDHAEFHEQCVERIFNDVLTQCAPQWLVVEARYTRRGGLDINPLRSSASVPTPLSIFRDLRQ
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).
Q8PFX6
Q9U4H5
AMX_DROME
TM2 domain-containing protein almondex
Sophophora
MRLQRQCIVVNMRSAIVLIMIFVLTGIRNSETASGGNQMDLSDSKGDHKDNSNASNGNGNANDNEVYVPPLVSSMVAKSGGGAGGLLDNITAYSSSSSSSSSNGNNNMLCPYDKETPCDRLQFPCIRCNYNHGCIYGRDLNVTCEVINNVQCLGERSFQRQMNCRYCYQTEMWQQSCGQRSSCNSATDKLFRTNCTVHHDVLCLGNRSFTRNLRCNWTQGYRWSTALLISLTLGGFGADRFYLGHWQEGIGKLFSFGGLGVWTIIDVLLISMHYLGPADGSLYI
Involved in the control of cell fates in the neurectoderm. Acts as a positive regulator of Notch pathway and is required at different levels during development.
Q9U4H5
B9FDT1
OST1B_ORYSJ
Ribophorin-1B
Oryza sativa
MAPSLSTAVSSLLLLLLLAAAISVSSSPPMPEDSIRVISAEKRIDLTSPIVKVFLTLKLENDATAPEASQVLLAFTPTEVEHLAIVKATRAEGKRKKKIYVPLSVKASDLAAAPNGARLYSILLSTPLKPAEVTTLEVFYALTHSLEPFPAEITQSDPQLVYYRDSAVLLSPYHVLEQVTYIKMPSNRVESFTRVDPTSRAGNEVKYGAYNNQLPNSYVPILVHYENNRPFAVVEEFVRKVEISHWGNVQITEQYKLKHGGAQHKGVFSRLEYQSRPSISGVSSFKNLLARLPPRVHSVYYRDEIGNISSSHLRSDSHKSELEIEPRYPLFGGWHCTFTIGYGLPLQDFLFESDDGRRYINLTFGCPLLDTVVDDLTIKVVLPEGSTSPQAVVPFLMEQYLETSYSYLDVVGRTTVVLKKRNVVGEHNVPFQVYYEFNPIFMLAEPLMLISAVFLFFVACIAYLHMDLSIGKS
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.
B9FDT1
B8D867
RF3_BUCAT
Peptide chain release factor 3
Buchnera
MFDSNHEQELSKRRTFAIISHPDAGKTTITEKMLFFGKVIRVPGTIKGRGSGKYAKSDWMNIEKERGISITTSVMQFTYKNILMNLLDTPGHQDFSEDTYRILTAVDCCLVVIDAAKGIEERTRKLMDVARIHNTPIITFINKLDRDSRDPIEILDEIEKELKLHCIPISWPISCGKNFRGVYHIHDKIIHLYKSKFRKNFLTLDSFLDGSLNEYLGADLSIYIRQELELIMNVYSKFNKEKFLKGITTPIFFGSALGNFGIDHLLDSLIKWAPSPLYRQSNKRIIKPQERNFTGFIFKIQANMDLKHRDRIAFMRIVSGQYTKGMKLTHVRIKKNIIISDAFSFLAGERISINKAYPGDVIGLHNHGTIKIGDTFTQGEEIKFIGIPSFAPEIFRLIYLKNPLKQKQLKKGLVQLSEEGTVQVFRPILNNDLILGAIGILQFDVVIERLRIEYNIDAVYKKVNIVLARWINCGNHHSLYNLKKSYSSYLAYDISNSLIYLAPSSANLNIVMSQNSDISFNATREQ
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
B8D867
A6QBQ7
KHSE_SULNB
Homoserine kinase
unclassified Sulfurovum
MLISVPATSANLGPGFDTLGLAVDLRNEIVIKPSKFLSLSTHGEGADNPKIKKNSLFLSIFNENYKRLSGKANNFRFEFTNRIPISRGLGSSSAVIVAALSGAYAMAGVKYNKREILNQALRYEHHPDNITPAVMGGFNVACVEGDRVYSKKRRMPDYLRAVVVVPNRTISTARSRTVLPKMYRKEETVYSLSRAAYMTALFMSESWDLLRIASKDKLHQARRMKMMPELFDVQKLALKQGALMSTLSGSGSTFFNLAYEKDTDRIAQSLRARFPQFRVFVLALDNNGVITK
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
A6QBQ7
B5XP99
THIM_KLEP3
4-methyl-5-beta-hydroxyethylthiazole kinase
Klebsiella
MPELLNPAPVAHLRHLLRAHSPLVHCMTNDVVQTFTANVLLAVGASPAMVIDPREAAQFAAIADALLINVGTLTEDRAVAMRAAVEHARQAGKPWTLDPVAVGALTVRTAFCHELLALQPAAIRGNASEILALAGMSAGGRGVDTTDTAAAALPAAQALARRLATVVAVTGEVDYVTDGERVLSVAGGNPLMTRVVGTGCALSAVVAASAALPGDRLENVAAACGLMKQAGEIAARQGGPGSFIPAFLDALYQEVQG
Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).
B5XP99
A8ZUH7
RUVB_DESOH
Holliday junction ATP-dependent DNA helicase RuvB
Desulfosudis
MKEKILTFSSDPSSPVTRHETEEDTGDDLFSLRPCDFEDYVGQDRTVETLRIAIAAAKQRSEPLEHVLFHGPPGLGKTTLAHIIAAEMGTSLTITSGPALEKGGDLIGMLTHLKRGDILFVDEIHRLPRTTEEFLYPAMEDFAVDFVFDKGIHARCHRYRLNQFVLVGATTRVGLLSAPLRDRFGIFRKFDFYSRQDLARIVSRSAALMGLTIDETCTMELARRSRGTPRIVNRLLKRVRDYVQVRHGGVITVSAIDDALALEGVDEKGLTGLDRSYLETIIQYYGGGPVGIEAIGATLQEETDTLVDVVEPFLLAEGLLQRTSSGRKATEAAYRHLGVQWRG
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
A8ZUH7
P29933
COBS_SINSX
Hydrogenobyrinic acid a,c-diamide cobaltochelatase subunit CobS
Sinorhizobium
MMSKIDLDISNLPDTTISVREVFGIDTDLRVPAYSKGDAYVPDLDPDYLFDRETTLAILAGFAHNRRVMVSGYHGTGKSTHIEQVAARLNWPCVRVNLDSHVSRIDLVGKDAIVVKDGLQVTEFKDGILPWAYQHNVALVFDEYDAGRPDVMFVIQRVLESSGRLTLLDQSRVIRPHPAFRLFATANTVGLGDTTGLYHGTQQINQAQMDRWSIVTTLNYLPHDKEVDIVAAKVKGFTADKGRETVSKMVRVADLTRAAFINGDLSTVMSPRTVITWAENAHIFGDIAFAFRVTFLNKCDELERALVAEHYQRAFGIELKECAANIVLEATA
Catalyzes cobalt insertion in the corrin ring.
P29933
A4SLP3
NUOB_AERS4
NDH-1 subunit B
Aeromonas
MKYTLTRIDPDAPVERYPQEQSQTVDDPLAQDATRGIMMGRLEEVLQDTVNWGRKNSLWPYNFGISCCYVEMCTAFTSPHDVARFGAEVIRASPRQADFMVIAGTPFIKMAPVIQRLYEQLLEPKWVISMGACANSGGMYDIYSVVQGVDKFLPVDVYIPGCPPRPEAFLQALMLLQDSIGKERRPLSWVVGDQGIYRPDMPAEKDRKRGERIKVTNLRTPDEI
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
A4SLP3
A6UTT2
ADHS_META3
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
Methanococcus
MKMFNNIKNTGKLIRLERIFDKKSEKTVIIPMDHGVSSGPVAGLKDMRTAINSVAEGGANSVLVHKGIVRHGHRGYGKDIGLIIHLSAGTGVSPDPNEKVIVTSVEEAIRMGADAVSVHVNMGAPTDCQMYQDLGKIAETCEYWGMPLIAMMYPRGEKITDEKDPEFVAHAARLGAELGADIIKTNYTGDIDSFKDVVKGCPAPIIIAGGAKSTDAEYLQMVKDSIEAGGAGVASGRNVFQHKDVIGITKATAMVVHENADVEEALKVIKK
Catalyzes a transaldol reaction between 6-deoxy-5-ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
A6UTT2
Q0BXJ3
PURA_HYPNA
IMP--aspartate ligase
Hyphomonas
MAGVVVVGAQWGDEGKGKIVDWLSSRADVVVRFQGGHNAGHTLVIDGKVFKLALLPSGLVRGGKLSVIGNGVVVDPWHMLTEIEGIQAQGIEVSPESLVLADNASLILPWHKDIDAAREGALGAAQIGTTKRGIGPAYEDRVGRRAIRVADLADPAALDLKIERLLAHHRPLRAGLDLPEPDGAALKAALLEIAPQVLAYAQPVWKLLDEKVRRGSRILFEGAQGVMLDVDHGTYPFVTSSSVVAGNASAGSGVGPGAISYVLGLAKAYTTRVGAGPFPTEQDNDIGKRLGTVGHEFGTNTGRARRCGWFDSVMVRQACATSGVTGLALTKLDVLDGFEEIKICTAYKLNGKTIDYFPAGLTDQAAVEPVYETLKGWSGSTRGARSWTDLPPEAVVYVRRLEELVGKPCALVSTSPEREDVILMRDPFEG
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q0BXJ3
B9L605
OBG_NAUPA
GTP-binding protein Obg
Nautilia
MFVDNIKLKVKSGKGGQGCVSFRREKFVVKGGPDGGDGGKGGDVIVECDKNTHTLSHYKGRKLLKAKNGRPGEGRKKHGANGEDLILKVPPGTVIKNAETGEVLLDMKEDGERKVLLEGGRGGLGNWHFRGPRNQTPRYAQPGEEGQELEIVLELKLIADVGLVGFPNAGKSTLISTLSNARPEIANYEFTTLTPKLGVVRVDEYRSFVMADIPGIIEGAHEGKGLGIEFLKHIERTSTILYMIDLSSYRDPVYQFKTLQKELKEYSEKLASRDYAIALTKCDSVEVEKIEEFFEKLGISKTEPKFKADPNLPCHFDDKTFVLPISSVANINIEALKFALFDLVEKNKRKENEENSF
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
B9L605
Q9H7U1
CCSE2_HUMAN
Protein GCAP14 homolog
Homo
MEEKTQIKTFLGSKLPKYGTKSVRSTLQPMPNGTPVNLLGTSKNSNVKSYIKNNGSDCPSSHSFNWRKANKYQLCAQGVEEPNNTQNSHDKIIDPEKRVPTQGMFDKNGIKGGLKSVSLFTSKLAKPSTMFVSSTEELNQKSFSGPSNLGKFTKGTLLGRTSYSSINTPKSQLNGFYGNRSAGSMQRPRANSCATRSSSGESLAQSPDSSKSINCEKMVRSQSFSHSIQNSFLPPSSITRSHSFNRAVDLTKPYQNQQLSIRVPLRSSMLTRNSRQPEVLNGNEHLGYGFNRPYAAGGKKLALPNGPGVTSTLGYRMVHPSLLKSSRSPFSGTMTVDGNKNSPADTCVEEDATVLAKDRAANKDQELIENESYRTKNNQTMKHDAKMRYLSDDVDDISLSSLSSSDKNDLSEDFSDDFIDIEDSNRTRITPEEMSLKEEKHENGPPQDMFDSPKENEKAFSKTDEWIDISVSDRSECTKHTSGNNLVSPDTDYRAGSSFELSPSDSSDGTYMWDEEGLEPIGNVHPVGSYESSEMNSIDILNNLESCDLEDDDLMLDVDLPEDAPLENVECDNMNRFDRPDRNVRQPQEGFWKRPPQRWSGQEHYHLSHPDHYHHHGKSDLSRGSPYRESPLGHFESYGGMPFFQAQKMFVDVPENTVILDEMTLRHMVQDCTAVKTQLLKLKRLLHQHDGSGSLHDIQLSLPSSPEPEDGDKVYKNEDLLNEIKQLKDEIKKKDEKIQLLELQLATQHICHQKCKEEKCTYADKYTQTPWRRIPGGYSAPSFSPWQGSFQGIPRTVPPHRRQTSSTTAFQQPSQTHRSHPGKTNKATTYRGPQ
Microtubule-binding protein which might play a role in microtubule bundling.
Q9H7U1
Q61XH2
TIPIN_CAEBR
CSM3 homolog
Caenorhabditis
MDEMDDFFGNDELDREPSPFGEEAIEDNTGEEGSRRIIEPKLLRTKKLTNPRLALNEKTLTGPKGITALREAFQNFNPNPKDDPYKNLEKMMKKYAYWGHLMFPKMKTEDVLNRVETLGTRRQVKLYIMKQRLGESTDDVENEKRETKSKNGIIDDGADDDEDDLFNDLPEKETPTKPINHTEKVVDSPEKKNGQVSNNDAEEEEYRMMEEERLREEQEAREAEAEDELMEDFDLNNDW
Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress.
Q61XH2
O14653
GOSR2_HUMAN
Membrin
Homo
MDPLFQQTHKQVHEIQSCMGRLETADKQSVHIVENEIQASIDQIFSRLERLEILSSKEPPNKRQNARLRVDQLKYDVQHLQTALRNFQHRRHAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKVHNGMDDLILDGHNILDGLRTQRLTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT
Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.
O14653
Q2GVL1
ATG8_CHAGB
Autophagy-related ubiquitin-like modifier ATG8
Chaetomium
MRSKFKDEHPFEKRKAEAERIRQKYADRIPVICEKVEKSDIATIDKKKYLVPSDLTVGQFVYVIRKRIKLSPEKAIFIFVDEVLPPTAALMSSIYEEHKDEDGFLYITYSGENTFGNFETA
Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.
Q2GVL1
A5VVJ8
HUTU_BRUO2
Imidazolonepropionate hydrolase
Brucella
MSNPRHNEREVRSPRGDELNAKSWLTEAPLRMLMNNLDPDVAERPHELVVYGGIGRAARTWDDFDRIVATLKTLNDDETLLVQSGKPVGVFRTHKDAPRVLIANSNLVPHWANWDHFNELDKKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEAGRQHYGGNLKGRWILTGGLGGMGGAQPLAAVMAGACCLAVECDETRADFRLRTRYVDEKTHSLDEALAKIDAWTKAGEAKSIALIGNAAEIFPELVKRGVKPDIVTDQTSAHDPVHGYLPLGWTVAEWRAKQENDPKAVEKAARASMKVQVQAMLDFWNAGIPTVDYGNNIRQMALEEGLENAFAFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIAKTDAKVKELLPDNKHLHNWLDMAKERIAFQGLPARICWVGLGDRHRLGLAFNEMVRNGELKAPIVIGRDHLDSGSVASPNRETEAMKDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGFSQHAGMVICCDGTEDADRRLERVLWNDPATGVMRHADAGYDIALDWARKQGLRLPAILGN
Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.
A5VVJ8
A4FZQ7
HIS3_METM5
Phosphoribosyl-AMP cyclohydrolase
Methanococcus
MDLDIKEIVKNMDLKFRNIEGKKLLLAISTDKSGKVLMTAFMSEESLEKSIETGFMHYYSTSRDKLWRKGEESGNVQKIINVFRDCDGDALLFTVEQTGWACHEGYMSCFHNKIDLSTGKSTVVGNKLD
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
A4FZQ7
Q1J118
FOLD1_DEIGD
Methenyltetrahydrofolate cyclohydrolase
Deinococcus
MTKAQLFGKPLADDVTRGVRAALKEWAGAEPGFQPHLVSVLASEDEASRVYVHSKARQAERLGVRFTARDLGADAKQDELHAVLQALSADADVHGVVLELPLAPGLDADAALRHIAPCKDVEGLTPANLALIAAGREAEALLPPTPRSVRFLLREVLGDDLRGRRVAVIGPGRTVGRPLTFMLNNRGVTVTLCNECTRDLRDVLAPQDAVVVAVGHAGLLRPEQVQPHHVVIDAGINVTPGGVVGDAVPDLPVRAQTPVPGGVGPLTSALMYQNLVRAVKLQRGERVE
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q1J118
Q4R755
GPDM_MACFA
mtGPD
Macaca
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQMNLAYVKAADYISEPVNREPPSREAQLLTLQNTSEFDILVIGGGATGSGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMKLDIEQYRMVKEALHERANLLEIAPHLSAPLPIVLPVYKWWQLPYYWVGIKLYDLVAGSNCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPQTGKVRVSGARCKDVLTGQEFDVRAKCVINATGPFTDSVRKMDDKDAAAICQPSAGVHIVMPGYYSPESMGLLDPATSDGRVIFFLPWQKMTIAGTTDTPTDVTPHPIPSEEDINFILNEVRNYLSCDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISESGLITIAGGKWTTYRSMAEDTINAAIKTHNLKAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAATYGDKAFEVAKMASVTGKRWPIVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWDDHKKQEQLETAKKFLYYEMGYKSRSEQLTDRSEISLLPSDIDRYKKRFHKFDADKKGFITIVDVQRVLESINVQMDENTLHEILNEVDLNKNGQVELNEFLQLMSAIQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL
Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device.
Q4R755
P41069
TRAV_ECOLI
Protein TraV
Escherichia
MKQTSFFIPLLGTLLLYGCAGTSTEFECNATTSDTCMTMEQANEKAKKLERSSEAKPVAASLPRLAEGNFRTMPVQTVTATTPSGSRPAVTAHPEQKLLAPRPLFTAAREVKTVVPVSSVTPVTPPRPLRTGEQTAALWIAPYIDNQDVYHQPSSVFFVIKPSAWGKPRIN
Involved in F pilus assembly. Appears to facilitate the polymerization of inner membrane-located pilin subunits into extracellular F pilus filaments.
P41069
Q02854
NUXM_NEUCR
Complex I-20.9kD
Neurospora
MSSTSSPTYTISKTLNTNYPLIDNDPHFRRVIGYARPSDYVHGTVAGAAGPGLLYLMEKMAPSGVGKGGFPKAMRLATAVGFFGGFLYFYQRSILRFYGMSENAREVQMDMREMVDKVKAGQPLYGVSTLPVDVQGMAARQSRYSALFFAVLPWFNFVNHNQHGVDTAKYYQQAERELEAERLGKGSSS
Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Q02854
Q8R9I2
PSTB2_CALS4
Phosphate-transporting ATPase 2
Caldanaerobacter
MKKIEVRDLDLFYGEVQALKKINLDVEPNSVLALIGPSGCGKSTFIRTLNRMNDLIEGVKISGTVLLDGKDIYKEVDVIELRKKVGMVFQKPNPFPMTVYDNVAYGPRIHGIRDKRTLNEIVEKSLKAAALWDEVKDRLHHSALSLSGGQQQRLCIARTLAVEPEVILMDEPTSALDPISTMKIEELIEELKKKYTIIIVTHNMQQAGRVSDYTAFFLNGELVEWGPTDQVFYNPKDKRTEDYITGRFG
Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.
Q8R9I2
Q4QM31
OBG_HAEI8
GTP-binding protein Obg
Haemophilus
MKFIDESLIRIEAGDGGNGCVSFRREKFIPKGGPDGGDGGDGGDVYLQADENLNTLIDYRFNKRFAAERGENGRSSDCTGRRGKDIILPVPVGTRAIDNDTKETLGDLTQHGQKMLVAKGGYHGLGNTRFKSSVNRAPRQKTMGTPGEKRDLLLELMLLADVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLVPSLGVVKVDDSHSFVVADIPGLIEGAADGAGLGIRFLKHLERCRVLIHLVDIAPIDGSNPADNVAIIESELFQYSEKLSEKPRWLVFNKIDTMSDEEAEERVREITEQLGWEEDYYLISAATRKNVPPLCRDIMDFIIANPREAETQQVAPEEVKFKWEDYHQEQLAGYQFDDDEDWDDDWTEEDDEGIEFIYKP
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Q4QM31
Q6ZGM7
YSL7_ORYSJ
Protein YELLOW STRIPE LIKE 7
Oryza sativa
MEPVNDFQEGISTEHAFEAEPVPSLSETITPRSMVVSFILSVTLSIVAMKVTLSSGFIPSFSIPAGLLGFCVSRASIRILDYFAVAQLPFTRQENTIIQTCVVACTSITFTGGFGTYILAMGKKAAVGDVNAQNNVEEPSFARMITFLFLISFAGMFIIMPFRKVMIIRHRLTFPSGTATAHLINSFHTPQGVKQARKQVTLLFKSFGGTIAWSLFQWFFASGPGCGFKFFPTFGLEAYKHGFFFDFTMANVGIGMMCPYMIVFSVFIGTIISCGVIWPYIESKEGIWYPSNLGPNSLNGIRGYKVFIGLSMIMADCLFVFLCIMVRTTCAMIKRRRQAMQGGGGNAQPFQGIDIADQPVKSFDDRRRAQVFLRDEIPDSVTIGCYVLLSIISIAAIPHLYPQMRYSHVALIYLAAPVFAFCNAYGFGVTDMNLASTYCKIAMFAFGSWVGIKSGGVVAALVAGGITMSILGNAADVAQDLKTGYLTLTSPRAVFISEAIGTALGCVVNPTVFWVFYRVYKMGSGDMGDMPYAKLYRGFAMLSVGDGEQGLPRHSMLLFKVFFVLALALSVFREVASRKEWRIRRYIPSTIGMAITFFMPPRVPVGMCIGSLVAYLWEKMDAGRGRMLSPALASGLICGDGVGSILLSMLTLMGARAPICIKFLSRGDNVKLDAFLATLHDMR
May be involved in the transport of nicotianamine-chelated metals.
Q6ZGM7
A1K5J4
MNMC_AZOSB
FAD-dependent cmnm(5)s(2)U34 oxidoreductase
Azoarcus
MPITPASLSFAEDGTPYSTAYGDVYHSSDGGLGQAHHVFLAGNGLPERWRGRERFVIVETGFGLGLNFLASWAAWRKDPQRSERLHFVSCELHPFRVEDLALLHARWPEFAPLAAELQANWPCLAPGVHRLHLDGGRVCLTLYFGDARDGLAQLDARADAFLLDGFSPAKNPDLWSARIFHLLARLAAADATLATWSVAGEVREGLRRAGFEVEKAPGFGGKRQMLRGRYLGRGHRPAPAAAERRALVIGAGVAGTSIAERLAARGWQVELLDAASGPAQGASGNHAGVLRPLPSLDDNRMGRLTRAGTLYGWRHIQRLQAAGLPLRAEACGVLHLARDAAQEAKMRAVVERLALPPAHLRFVSAAEASEIGGWPVPLGGWWFGDSGWVQPPSLCAANLSAGGEGIRAHWNARVTLARADTRWQARDAQGALLAEAPVAILAAGTGITGFPLAAPLPVVSARGQVSLLPAPAGSAPRVVMCRMGYVSPAVDGLRCAGATFDVGDDDATLRARDHHENLSKLEAMLPGYTAALATQPAEGRVGFRPASPDRLPMVGAVPALTTLAAPCALAEIPRHTGLYALSGFGARGLVWATLAAETLASQLDGEPLPLERDLVDALDPARFLLRPARTLRGED
Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34.
A1K5J4
P65598
ORN_MYCBO
Oligoribonuclease
Mycobacterium tuberculosis complex
MQDELVWIDCEMTGLDLGSDKLIEIAALVTDADLNILGDGVDVVMHADDAALSGMIDVVAEMHSRSGLIDEVKASTVDLATAEAMVLDYINEHVKQPKTAPLAGNSIATDRAFIARDMPTLDSFLHYRMIDVSSIKELCRRWYPRIYFGQPPKGLTHRALADIHESIRELRFYRRTAFVPQPGPSTSEIAAVVAELSDGAGAQEETDSAEAPQSG
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
P65598
A8FCU5
CTAA_BACP2
Cytochrome aa3-controlling protein
Bacillus
MKFALRLLSVITTFVMLIVLIGGALVTKTGSGLGCGRQWPLCHGRFFPEMNPASIIEWSHRMSTGVSTILVLALAVLCWKKISPVFRETKFLVIMSIIFLLLQALLGALAVVFGSNALVMALHFGISLISFASVLLLALLVFEATRSETKLVKPLHIGKKMQFHIYGLITYTYIVVYTGAYVRHTKSSLACSVFPFCSKDGALPAYFNQWVQMSHRAAALLLFVWIFVAMFHAMKHYKEQKQLYYGWIISAILITLQAISGVMSVYSQLALGYALAHSFFISCLFGVLCYFCLLIARFKYESKEPFK
Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
A8FCU5
Q9RXC9
ISPG_DEIRA
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Deinococcus
MSFDSLPALPLDPLPDAALPTAPRRRQTVSVNVGGVMVGSAHPIVVQSMTNTDTANAEATAIQVAQLARAGSEIVRVTVNTREAAAAVPELVQRLADIGVHVPIVGDFHYNGHLLLREYPETARLLAKYRINPGNVGAGQRHDENFATMIEVAKEFDKPVRIGVNWGSLDQQVLARLMDENAAAGHPKSPTDVTIDAMIVSALDSARFAEELGLGHDKILISVKVSSAPELWQVYRQLAPLCDYPLHLGLTEAGMGMKGIVASSVALAPLLTEGIGDTIRVSLTPEPGAPRKLEVEVAQQILQSLGLRQFLPQVTSCPGCGRTTSSFFQTLAQKIQDFIRESMPEWKAKYPGVEDMQVAVMGCVVNGPGESKHANIGISLPGTGEDPRAPVYQDGKLLTTLKGPRIAEEFQELLEKYVEERYGQGVAQG
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Q9RXC9
Q9PNI7
CLPS_CAMJE
ATP-dependent Clp protease adapter protein ClpS
Campylobacter
MPKTQTLEQTKLSEPKMYKVILLNDDVTTMDFVIEILMNIFHQNLEKASQTMLEIHHNGSGICGIYTQEIALSKQKKVMDAAKLANFPLQAKVEEE
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
Q9PNI7
Q9W799
CPSF2_XENLA
Cleavage and polyadenylation specificity factor 100 kDa subunit
Xenopus
MTSIIKLTTLVGAQEESAVCYLLQVDEFRFLLDCGWDENFSMDIIDSVKKYVHQVDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFSLFSLDDVDCAFDKIQQLKYNQIVHLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMINRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLTLCHGYSDLARVPSPKVVLASQPDLECGFSRELFIQWCQDPKNSVILTYRTTPGTLARFLIDHPSERIIDIELRKRVKLEGKELEEYVEKEKLKKEAAKKLEQSKEADLDSSDDSDVEEDIDQITSHKAKHDLMMKNEGSRKGSFFKQAKKSYPMFPAPEDRIKWDEYGEIIKPEDFLVPELQVTEDEKTKLESGLTNGDEPMDQDLSDVPTKCVSTTESMEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPDATQDLAEACRAFGGKDIKVYTPKLHETVDATSETHIYQVRLKDSLVSSLKFCKAKDTELAWIDGVLDMRVSKVDTGVILEERELKDEGEDMEMQVDTQVMDASTIAQQKVIKSLFGDDDKEFSEESEIIPTLEPLPSNEVPGHQSVFMNEPRLSDFKQVLLREGIHAEFVGGVLVCNNMVAVRRTETGRIGLEGCLCEDFFKIRELLYEQYAIV
CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. In X.laevis this subunit seems to be predominantly involved in cytoplasmic polyadenylation reaction. May also be involved in the histone 3'-end pre-mRNA processing.
Q9W799