Datasets:
habdine
/
Prot2Text-Data

Dataset card Data Studio Files
xet
Community
1
accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
⌀
taxon
stringlengths
3
46
⌀
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q8CV64
RECX_OCEIH
Regulatory protein RecX
Oceanobacillus
MKKIARITTQKKHKNRYNIFLQTPDGGDAYGFSVDEAILIEYRLSKGMELEDEMISILEQKDTLHKAYTLTIHFLSYRMRSEKEVSDYLQKKEVDEEHIAEIIKRLKKEKWVDDQQFAEMFVRSRINSSSKGPKMIQQELFEKGVDGSKITSALEQYPVEEQKQKVEKLISKKLQSKSKDSHQKRIDQIKQNLMQKGFDSGVISMVIQQMDTTEDTDREWEVLQLQGEKLLYKYQKKHSGFALKQKVMEGLYRKGFSFDMINQFIDQSLQDE
Modulates RecA activity.
Q8CV64
Q5HC05
RPOB_EHRRW
Transcriptase subunit beta
Ehrlichia
MSSSVTSKYVLNSFSSVPRLSYAKSIDIKDSLTDLIKIQRDSYNAFIGIDQDVDSGIKNIFQSMFPIQDLLGRAVLQFVSYSIGEPQYDEYECIKRGITYSVPIRIVLRFIVWKVQEVSFKEVKYVVDEETSEKSIKYIKEQEVSIGDLPTMTSYGTFIINGVERVIVSQMHRSPGVFFDSDKGKTYSSGKLIYLARIIPYRGSWLDFEFDIKDILYFRIDRKRKLPVSLLLRALGLSNSEILDTFYDKIRYERCENGWVVPFVVDRFRGVRLSYDLVDIDGNVLVKANTRITLRLAKKLASDGLKKYLVPFAEIQGLFIANDLVDPASNVMIMCAGESITSEHINKLKLFDINEIFILNIDFLTVGPYILNTLFLDKNISYEDALFEIYKVLRSGESPSLDTMKAFFDGLFFEKERYDLSTVGRIKLNDHLGLDISEDVTVLTKDDIIHVIKKLVLLRDGEGFVDDIDHLGNRRVRSVGEFIENQFRIGILRLERMIMDYMSSVNFDNAMPCDFVNPKVLATVLKDFFSSSQLSQFMDQTNPLSEVTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGQNIGLISSLAIYARINKHGFIESPYRKVDNGVVTDKVEYLLAMQESNYYIADASATLDENNRFVDDMLYCRHDGNFVMVKREQVDYIDVSPKQIVSVAASLIPFLENNDANRALMGSNMQRQAVPLLKADAPLVGTGMESIVAAGSGTVVLAKRSGIVHRVDGLYIVIRAFDKEKNEYLGVDIYNLRKFQRSNHNTCINQKPLVKPGDYVRENDVIADGSAIDQGELALGKNVLVAFMSWQGYNFEDSIVISSEVVKKDVFTSIHIEEFECVVRDTALGPEKIMRSIPDVNEDSLSHLDDVGIVNVGAEVSAGDILVGKVTPRPPVSLPPETKLLVTIFGEKVFDCVDSSLYLPIDVEGTVVDVHVFVRRGVEENDRSLLIKQNEINGFIKERDYEIDVVSEYFYDELKRVLVNTNTEYNNQNIEDYLKSIPQKSWWDIKLSDESVLSQISDLKEKFDSMIENAHSKFDQKIDKLNYGYDLPQGVLCIVKVFVAVKHNLQPGDKMAGRHGNKGVISRIVPVEDMPYLEDGTPVDIILNSLGVPSRMNVGQILETHLGWASVNLGKKIGNILDNIDELTIAHLRNFLDQVYDGQDLKYSIRSMSDDDLLAFAERLRDGVPMAAPVFEGPKDNQISNLLKLADLDVSGQVDLYDGRIGEKFDRKVTVGYIYMLKLHHLVDDKIHARSVGPYGLVTQQPLGGKSHFGGQRFGEMECWALQAYGAAYTLQEMLTVKSDDIVGRVKIYESIIKGDSNFECGIPESFNVMVKELRSLCLDVALKQDKDFLHDRKINN
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q5HC05
A9HDX7
DCUP_GLUDA
Uroporphyrinogen decarboxylase
Gluconacetobacter
MTDTGKPLLRVLQGEAVWPPPIWLMRQAGRYLPEFRALRDQADFITRCMTPDLATEITLQPIRRYAMDGAILFSDILILPWAMGQSLDFVAGKGPILGAIRSEADLARLDPKRVPDATAPVMETLSRLRAILDGPDPIGAAQGGRVTLLGFAGAPFTVACYMVEGHGSREFDATRGMAYSDPLLFDRLMATLTQATADMLVAQIDAGAEAVMLFDSWSGLLPPAQFRRHVIAPTRAIVQEIQARRPGVPVIGFPRLAGIMAAEYARETGLRVMALDTGADMAAMAGLLPPGMTVQGNLDPLLLLAGGDAMAQEARAIRDAMKGRPHVFNLGHGVVPPTPPEHVGDLVRTVREV
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
A9HDX7
Q87KN8
TRMA_VIBPA
tmRNA (uracil(341)-C(5))-methyltransferase
Vibrio
MATLDVNPQRYQEQLAEKVERLTDMFAPYNVPELEVFESPEQHYRMRAEFRVWHEGEDLYYIMFNQETREKYRVDQFPAASRLINDLMPLLVEAMKDNESLRRKLFQVDFLSTLSGEILVSLLYHRQLDEEWIENAKALKQRLNDEGFNLNIIGRARKMKIILDRDYVIEKLDVNGQSYIYQQVENSFTQPNGKVAEKMLEWAVDCTQESTGDLLELYCGNGNFSLALAQNFDRVLATELAKPSVESAQYNIAANKIDNVQIIRMSAEEFTEAMEGKREFRRLKDNGVDLKSYNCNTIFVDPPRAGMDVDTCKMVQGYERIMYISCNPETLKENLDILSETHNVTRFALFDQFPYTHHMEAGVLLERKA
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
Q87KN8
Q8C522
ENDD1_MOUSE
Endonuclease domain-containing 1 protein
Mus
MGCARWLALGGLLALAGLLQARLLLPQQAGFGECDRFFYKGTPPAGLATEAHVRICQRFAGSERFATLYSPGHRIPVFSAFRAARPASRSAEQRGLLEPQIDDPDSNLEEVIDEANALTSVDNLGSKQALNADYIDSDYEIGQLYPFPLNSDLQMATFPLTNSVPMTQSFRERWHMNLNSLMDRALIPHCSEGKDLYILTGAVPSEHRVKGKVTIPEFVWLAACCAVPGEGWAMGFIKHTQDIDVIEDVMLRDLEKLLPHKPQLFQDNCGEMEQDTEKMKKILEVVNQVQDEERSLQSQERMSPLASTQSQRSALLSPEAPPEGGSSFLGQVLGFLATPFIKLFQLIYYLVTAVLRNIVHLLWLVAKQAINTVESCLYHLGEATVSYLVAIGQELVSIPWKVLKVVAKVIRAFLRILCCLLKAVCRALSIPLRVLVDVATFPVYTVGAIPIVCKDIAVGLGGTLSLLFDTAFGTVGGLFQIVFSVFKRIGYKVTLDNSGEF
May act as a DNase and a RNase. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26.
Q8C522
B1YVL0
PLSX_BURA4
Phosphate-acyl-ACP acyltransferase
Burkholderia cepacia complex
MTVKLTIDCMGGDHGPSVTVPAAVKFVRAHPDAHLMLVGIESAIRAQLKKLKALDDPALTIVPATEVVAMDDPVEVALRKKKDSSMRVALNQVKEGAAQACISAGNTGALMAVSRYVLKTLPGIERPAIAFALPNPTGYTMMLDLGANVDCEPQHLLQFAEMGHALVAALEGKERPTIGLLNIGEEVIKGNETIKRAGELLRASTLNFRGNVEGNDIYKGTVDVIVCDGFVGNVALKTSEGLAQMLSDIIREEFGRSLMSKLMALLALPVLMRFKKRVDHRQYNGAALLGLKGLVIKSHGSADAYAFEWAIKRGYDAVKNGVLERLARAMADNSVSLGDGGHDAGGAGTASPAPGHHAEPSAAQSSKA
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
B1YVL0
I6Y3V5
IPDE1_MYCTU
5OH-HIP-CoA dehydrogenase alpha subunit
Mycobacterium tuberculosis complex
MQDVEEFRAQVRGWLADNLAGEFAALKGLGGPGREHEAFEERRAWNQRLAAAGLTCLGWPEEHGGRGLSTAHRVAFYEEYARADAPDKVNHFGEELLGPTLIAFGTPQQQRRFLPRIRDVTELWCQGYSEPGAGSDLASVATTAELDGDQWVINGQKVWTSLAHLSQWCFVLARTEKGSQRHAGLSYLLVPLDQPGVQIRPIVQITGTAEFNEVFFDDARTDADLVVGAPGDGWRVAMATLTFERGVSTLGQQIVYARELSNLVELARRTAAADDPLIRERLTRAWTGLRAMRSYALATMEGPAVEQPGQDNVSKLLWANWHRNLGELAMDVIGKPGMTMPDGEFDEWQRLYLFTRADTIYGGSNEIQRNIIAERVLGLPREAKG
Involved in cholesterol degradation. Catalyzes the dehydrogenation of 5OH-HIP-CoA to 5OH-HIPE-CoA . Can also use octanoyl-CoA and dihydroferuloyl-CoA, with lower efficiency. Cannot use 3-oxo-4-pregnene-20-carboxyl-CoA (3-OPC-CoA) .
I6Y3V5
Q5E2G4
GPH_ALIF1
Phosphoglycolate phosphatase
Aliivibrio
MFEDIKLIAFDLDGTLLDSVPDLARAVDLAMQDMGYPRVTLEQASHWIGNGADVLVSRALSQNYIVKDDLDAELIKQARARLDQHYHDGGHQLSHLYPDVKDTLERLHQQGYTLALVTNKPSQFVPELLEQHQLTHLFSEVIGGDTFAEKKPNPFALNWLLDKHGLTAPQMLMVGDSKNDIQAAQAAGCHSFALTYGYNHGEPISDSQPDVVSDEFKYLLAVLSMAR
Specifically catalyzes the dephosphorylation of 2-phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress.
Q5E2G4
Q979K2
RL13_THEVO
50S ribosomal protein L13
Thermoplasma
MKIIDASNTVYGRLSAYVAKQLLNGEEVVIVNASKAVITGDRKFIIDKFKQRLDIGSVRKGPYYPKTPENILRRSIGDMLPKKITRGKEALSRCKVYRNLPKNVSSEKIEKVDDVMTDKVVGIITLEELSKELGGM
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Q979K2
P32731
RBFA_BACSU
Ribosome-binding factor A
Bacillus
MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQIAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNRIETLIHELHSEKPSE
One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
P32731
P97484
LIRB3_MOUSE
Paired immunoglobulin-like receptor B
Mus
MSCTFTALLRLGLTLSLWIPVLTGSLPKPILRVQPDSVVSRRTKVTFLCEETIGANEYRLYKDGKLYKTVTKNKQKPENKAEFSFSNVDLSNAGQYRCSYSTQYKSSGYSDLLELVVTGHYWTPSLLAQASPVVTSGGYVTLQCESWHNDHKFILTVEGPQKLSWTQDSQYNYSTRKYHALFSVGPVTPNQRWICRCYSYDRNRPYVWSPPSESVELLVSGNLQKPTIKAEPGSVITSKRAMTIWCQGNLDAEVYFLHNEKSQKTQSTQTLQEPGNKGKFFIPSVTLQHAGQYRCYCYGSAGWSQPSDTLELVVTGIYEYYEPRLSVLPSPVVTAGGNMTLHCASDFPYDKFILTKEDKKFGNSLDTEHISSSGQYRALFIIGPTTPTHTGAFRCYGYYKNAPQLWSVPSALQQILISGLSKKPSLLTHQGHILDPGMTLTLQCFSDINYDRFALHKVGGADIMQHSSQQTDTGFSVANFTLGYVSSSTGGQYRCYGAHNLSSEWSASSEPLDILITGQLPLTPSLSVQPNHTVHSGETVSLLCWSMDSVDTFILSKEGSAQQPLRLKSKSHDQQSQAEFSMSAVTSHLSGTYRCYGAQDSSFYLLSSASAPVELTVSGPIETSTPPPTMSMPLGGLHMYLKALIGVSVAFILFLFIFIFILLRRRHRGKFRKDVQKEKDLQLSSGAEEPITRKGELQKRPNPAAATQEESLYASVEDMQTEDGVELNSWTPPEEDPQGETYAQVKPSRLRKAGHVSPSVMSREQLNTEYEQAEEGQGANNQAAESGESQDVTYAQLCSRTLRQGAAASPLSQAGEAPEEPSVYATLAAARPEAVPKDMEQ
May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM).
P97484
B2A8M8
THII_NATTJ
tRNA 4-thiouridine synthase
Natranaerobius
MYNYLLIRYGEIGLKGKNRSYFEKSLVKNMQSALKDLEIGKIKSTQGRMYIPLSGSSDELTRVLDRVTRVFGIETVSPAVKVESDLEVIKKTALQVFKNHMDSISPQNQVSFKVDCRRADKLFSKNSMEMNQILGAHILDHVPGLKVDVKQPQILLQVEIREDGTYIFTEKIPGHGGLPIGTTGKGVLMLSGGIDSPVAGWLAMKRGIQVVGLHFHSYPFTSQRALKKVEDISQVLSRYGTGPTGGFKLITNHFTDIQKAIQNYCSESMWVTVMRRFMFYIANRMAQKEQAMTVVTGENVGQVASQTLESMHAVSQDVVNLPILRPLAGLDKKEIMSKAETIGTYDISIRPYEDCCTLFLPKNPKTRPSLEQTKREISKLNFEELVEESLEKTEIKYFEPYQDITEEELTFDV
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
B2A8M8
P19579
CAPA_BACAN
Capsule biosynthesis protein CapA
Bacillus cereus group
MRRKLTFQEKLLIFIKKTKKKNPRYVAIVLPLIAVILIAATWVQRTEAVAPVKHRENEKLTMTMVGDIMMGRHVKEIVNRYGTDYVFRHVSPYLKNSDYVSGNFEHPVLLEDKKNYQKADKNIHLSAKEETVKAVKEAGFTVLNLANNHMTDYGAKGTKDTIKAFKEADLDYVGAGENFKDVKNIVYQNVNGVRVATLGFTDAFVAGAIATKEQPGSLSMNPDVLLKQISKAKDPKKGNADLVVVNTHWGEEYDNKPSPRQEALAKAMVDAGADIIVGHHPHVLQSFDVYKQGIIFYSLGNFVFDQGWTRTKDSALVQYHLRDNGTAILDVVPLNIQEGSPKPVTSALDKNRVYRQLTKDTSKGALWSKKDDKLEIKLNHKHVIEKMKKREKQEHQDKQEKENQVSVETTT
Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC.
P19579
C0QAY0
FOLD_DESAH
Methenyltetrahydrofolate cyclohydrolase
Desulforapulum
MAEVLKGKPVADALKAELTKNIEALKKDKGITPKLGIIRVGARPDDLFYEGGAKKTCAAVGMDCEIFEYPEDIDQASFEKAVTEVGAKKDVNGILMFSPLPKNLDERKIRTLIPVEKDVDCLTTGGAAKVFTDDATGFPPCTPTACMEMLHFYDIPIKGKKCVVVGRSLVVGKPLAMLLLREHGTVTICHSRTENLPGVCQDADILIAAVGRAKMVKADFVKKGQIVIDVGINADPDRPGKYCGDVDFETVEPVVTKITPVPAGVGSVTTSVLCKQTFMACQMQNA
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
C0QAY0
O42668
TPR1_SCHPO
Tetratricopeptide repeat protein 1
Schizosaccharomyces
MEGFTLETHASRIIEVPLLGQEDQSVEIDCSSLPSDATELCEILVNEQAPREFWTKFAHEYYIRGLREQAILILKSGLETLKDSESLCILNANIAAIYLSMAREAMLKKDTDLRDEQLRNVRTYLEAANNIDSKSEINVLLHGIYRILLNPTDKESLENAARCFDFVLQKSGGNILGFLGKARILYAKGNYRSALKLYQRALVSNPQFKPDPRIGIGLCFWNLDMKTDALSAWTRVQQLDPKNTVVDTYIGLYYYDLAFQNVNNDSFVQNYGKALQHIQRAFKTRNNDPVASSILERYVYSKKNYEGCIKLAENVIQNSFSSSLIADGYYWMGRAYHQMGNNEKAMASYQKAKAADDRHLLSSVGIGQIQILQNDLTSAKLTFERIAEQNQSCFEALVVLGCLHASDSKPDLTKARMLLDRAFNLVGSSKLPRVVDSDLYITQARLWEKEDTKKSLGFLTRALDFLESAHMSVGPELLNNIAVLQYHLGLIPEAHGNIIKAKSVLPDANPELSLLLDYNLARCEEELGNTSVASEAYVSILEKHPSFIDARIRKCLLQLSNPNEETFKEIRHIMNADSQNLEVRAFFGWYLSKQKRRPVEDPEVRHCSQTLRHWHDDIYSLVQLGNAYMRQAREFRVHNDREKLKRQKLYIKAIQSYDQAIKFDPKNAHAAQGIAIILAQNRQFSKALLILSKVREAIKDATTLINIGNCLAELKQFSRAIEVFETVYSSTGESDTYGVLSCLGRVWLQRGRESKNVDYLKESVRYATLALEKNPENPSLLFNVAFVQFQLCELIRQKPENSRTVEDLNFAMQQLDASIETFTKLVSVEHPPYSPTSIEQRAKMAKNTTKRQLERAIQAQIEYEKSVAAKLEDARIQREKEKARRLAEEEALLKEKQERERQLQEERQKMQEEVLEWRKSQQKASEDDMSLSDDEEKQSGKKKKKDRKKRKSKSKQESSDSGVSEDDEIPLSDARNKTKKRRVNRRVISEEYTFDQDSDAEGNQEEEVSRTIEEKQDNDITDNQDDNKELNLFSEEDEE
Involved in promoting potassiumm ion uptake.
O42668
Q5L0U5
PYRC_GEOKA
Dihydroorotase
Geobacillus thermoleovorans group
MGVWLKNGMSFNKDGELMRTHIKIEHGTIAAILYEQPLEANEEDVIDVGGRLIVPGLIDLHVHLREPGGEAKETIETGTLAAAKGGFTTVAAMPNTNPAPDRKEQMEWLQARIRETARVNVLPYAAITIGQKGEELTDFAALKEAGAFAFTDDGVGVQSAGMMFEAMKQAAALDMAIVAHCEDDTLTNGGAVHDGEFARRYGLRGIPSVCEAVHIARDVLLAEAAGCHYHVCHISTKESVRVVRDAKRAGIRVTAEVTPHHLLLCDEDIPGLDANYKMNPPLRSREDRDALIEGLLDGTIDFIATDHAPHTAAEKAKGIEAAPFGIVGLETAFPLLYTHFVKTGVFTLKQLVDWLTIKPAQCFGLKAGRLAVGAPADIAVIDLETEEAIDPETFASKGKNTPFAGWVCQGWPVMTFVGGTLVWEKGRA
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Q5L0U5
Q8U9K6
RUVB_AGRFC
Holliday junction ATP-dependent DNA helicase RuvB
Agrobacterium tumefaciens complex
MSDADRLITPEKRGEDIDTTLRPQSLDDFTGQAEARANLKVFIEAAKNRGEALDHVLFVGPPGLGKTTLAQIMAKELGVNFKSTSGPVIAKAGDLAALLTNLEERDVLFIDEIHRLNPAVEEILYPAMEDFQLDLIIGEGPAARSVKIDLSKFTLVAATTRLGLLTTPLRDRFGIPVRLAFYTVDELELIVRRGARLMGLNMTDGGAREIARRARGTPRIAGRLLRRVRDFAEVARAEAVTREIADEALTRLLVDNMGLDQLDMRYLTMIAVNFGGGPVGIETIAAGLSEPRDAIEDIIEPYMIQQGFIQRTPRGRILTATAWKHLGLQPPKDLEAAQFRLTLEDD
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
Q8U9K6
Q9Y708
CGR1_EMENI
rRNA-processing protein cgrA
Aspergillus subgen. Nidulantes
MSSAAPAPSTHAAKSIRKNGKNWHDNKKPFRPNGGLTSYTKRAAARKEQEAIKEYEKELREEREAERQAHIQRIKERRAAKEEKERYEKMAEKMHRKRVERLKKREKRNKLLNS
Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.
Q9Y708
Q0HYA3
CYSC_SHESR
Adenosine-5'-phosphosulfate kinase
Shewanella
MSNIVWHQHSVDQADRAKLKGQNPVLLWFTGLSGAGKSTLAGALERALFDAGFHTYLLDGDNVRHGLCKDLGFSVADRDENLRRVGEVAKLMVDAGLVVLSAFISPTREERDSIRARFPEGQFIEVHVSTPLSICEQRDPKGLYVKARRGEISNFTGISSPYEAPLSAELTIDTSKGDLASQVRALIDYLTAIEVINPSRLTASA
Catalyzes the synthesis of activated sulfate.
Q0HYA3
Q7SZ73
FXL15_XENLA
F-box/LRR-repeat protein 15
Xenopus
MAKDEDNSRVHLLDLPWEDVLVPHILSYLPLRHILSLQRVSKPFHSLVHIYLCNCRHFDSTQLGPQLPKTTFSELLKNNTVLQKLDLQSCSDWLTDKELLPIIGQNHHLTYINLNSCGQLTRQSLVAISLSCPHLQNICLGHCDWVDCLSMRSLADHCKCLEAIDLTACRQLKDDAISYLVQKSTRLKSLSLAVNANISDIAVEETAKSCRDLEHLDLTGCLRVKNDSIRTLAEYCNNLKSLKVKHCHNVTESSLGNLRKREVVLDVEPPLQRALVLLQDVVGFAPFINLQI
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts as a positive regulator of the BMP signaling pathway). Required for dorsal/ventral pattern formation (By similarity.
Q7SZ73
Q4L7Y6
ATPA_STAHJ
F-ATPase subunit alpha
Staphylococcus
MAIKAEEISALLRSQIENYESEMSVTDVGTVLQIGDGIALIHGLNDCMAGELVEFSNGVLGLAQNLEESNVGVVILGPYTEITEGDEVRRTGRIMEVPVGEELIGRVVNPLGQPIDGQGPINTTKTRPVEQKATGVMARKSVDEPLQTGIKAIDALVPIGRGQRELIIGDRQTGKTTIGIDTILNQKGLDTICIYVAIGQKDSTVRANVEKLRQAGALDYTIVVSASASEPSPLLYIAPYSGVTMGEEFMFNGKHVLIVYDDLTKQAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNDDLGGGSITALPIIETQAGDISAYVPTNVISITDGQIFLQSDLFFSGVRPAINAGQSVSRVGGSAQIKAMKKVAGTLRLDLASYRELESFAQFGSDLDEFTARKLERGKRTVEVLKQDQNKPLPVENQVLIIYALTKGYLDDIPVEDITRFEDELNSWTKSNGSDLLNEIRETGGLPSDDKFEATINEFKKSFSKSE
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
Q4L7Y6
A4YCR6
EF1A_METS5
Elongation factor Tu
Metallosphaera
MSQKPHLNLIVIGHVDHGKSTLVGRLLMDRGFLDEKTIKEAEEAAKKLGKESEKYAFLLDRLKEERERGVTINLTFMRFETKKYFFTIIDAPGHRDFVKNMITGASQADAAILAVSARKGEFESGMSLEGQTREHIILAKTMGLNQVIVAITKMDVAEPPYDQKRYNEIKETIEKFMKSFGFDMSKVKFIPIVSITGENVTKRSENMKWYNGPTLEEALDMLEIPPKPVDKPLRLPIQEVYSISGVGTVPVGRVESGVMKVGDKIVFMPAGKSAEVRSIETHHTKLEKAEPGDNIGFNVRGIDKKDVKRGDVVGHTTNPPTVAEEFTARVIVVWHPTALAVGYTPVVHVHTASIACRVSEIVARLDPKTGKEAEKNPQFIKQGESAIVKFKPIKPLCVEKFSDFPPLGRFAMRDMGKTVGVGVINDVKPSKIEIK
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
A4YCR6
Q8DST2
MURE_STRMU
UDP-N-acetylmuramyl-tripeptide synthetase
Streptococcus
MITIETVLTILKNNANFREIIDGKHYQYKYSNPEVAFHHISYDSRDIKASTLFFVKGATFKKEFLEKAIESGLTFYVAEKDYQVGIPLILVNNIKNAMCLIAKEFYDNPQDKLKTLAFTGTKGKTTAAYFAYHILKQGYRPAMISTMNTTLDGKTFFKSKLTTPESLDLFKMMAQAVANGMTHLIMEVSSQAYLVGRVYGLTFDVGVFLNISPDHIGPIEHPTFEDYFYHKRLLLKHSRYVIVNSQMNHFALIKEQVADQPHDFYGKYSDNQIINSKAFSFDLTGKLAGHYDIQLTGSFNQENAVAAALACLQLGASQTDIQKGIVQTTVPGRMEVLIQKNGAKVFVDYAHNGDSLEKLLSVVEEHQKGTLILILGAPGNKGESRRADFGYVINAHPELQVILTADDPNNEDPQLISQEIAHHIKRPVNIIVDRKQAIQKAMSLTQSENDAVIIAGKGADAFQIIKGKRTAYAGDIEVARKYL
Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Q8DST2
P80859
6PGD_BACSU
GNTZII
Bacillus
MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQEAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGNTYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAISAKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVFAEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVPLPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSYAQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDSYFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFGAHTYERTDKEGIFHTEWMK
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. Is the predominant 6-P-gluconate dehydrogenase isoenzyme in B.subtilis during growth on glucose and gluconate.
P80859
Q9RYZ2
Y2861_DEIRA
Uncharacterized protein DR_A0161
Deinococcus
MSAGSLGGRSRLDEQLERMTADFLSMQDTLAGQLRALQAAFAQGDTSVREEVERLDRDIDAANARIEGEALHLLARQSPVAHDLKLTLLILQSTPDLERAGDYAKHVARRLSALRAGTAGHPSEFAQALALLLQMATTLRAASSPMNAALAHEVRALDDQVDALYDRAVEQVLAGRPDAALADTLEASHAWRAAERLGDHLVNVAQRTERLLARPAPSDAPA
Not known; probably involved in phosphate transport and/or metabolism.
Q9RYZ2
A1UK02
KHSE_MYCSK
Homoserine kinase
unclassified Mycobacterium
MTQTLPAGLTATATVAASSANLGPGFDSLGLALSLYDEIVVETVDSGLTVTVEGEGAGQVALDSSHLVVRAIEAGLRATGCIAPGLVVRCRNDIPHSRGLGSSAAAVVGGLAAANGLVSQTDWTPLTVEQLIQLSSAFEGHPDNAAAAVLGGAVVTWTDGAGAQARYAAAPLRVHPDIHLFPAIPQQRSSTAETRVLLPDTVSHTDARFNLSRAALLVVALTERPDLLMAATEDVLHQPQRAAAMPASAEFLRVLRGCGVAAVLSGAGPAVIALSTEPVLPAEAVEFGIANGFTIAEMAVGDGVRWSTGVAAGR
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
A1UK02
A0KF22
RL4_AERHH
50S ribosomal protein L4
Aeromonas
MELVMKDAKSALEVSETTFGREFNEALVHQVVVAYAAGARQGTRAQLTRSEVSGGGKKPWRQKGTGRARAGSIRSPIWRSGGVTFAAKPQDHSQKVNKKMYRGAIRSILSELVRQERLIVVEKFGIEAPKTKELIAKLKEMELTDVLIVTAEVDENLFLAARNLYKVDVRDVAGIDPVSLIAFDKVLMTADAVKQIEEMLA
Forms part of the polypeptide exit tunnel.
A0KF22
P18949
METC_SALTY
Cysteine-S-conjugate beta-lyase
Salmonella
MTDKQLDTKLVNAGRSKKYTLGSVNSVIQRASSLVFDTVEAKKHATRNLANGELFYGRRGTLTHFSLQEAMCELEGGAGCALFPCGAAAVANTILAFVEQGDHILMTNTAYEPSQDFCSKILGKLGVTTSWFDPLIGADITQHIQPNTKVVFLESPGSITMEVHDIPSIVSAVRRVAPEAVIMIDNTWAAGVLFKALEFDIDISIQAGTKYLIGHSDAMVGTAVANARCWEQLRENAYLMGQMLDADTAYMTSRGLRTLGVRLRQHQESSLKIAAWLANHPQVARVNHPALPGSKGHAFWKRDFTGSSGLFSFVLNKKLTEAELSAYLDNFSLFSMAYSWGGYESLIIANQPEQIAAIRPAGGVDFTGTLVRVHIGLESVDDLIADLAAGFARIV
Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis.
P18949
Q3K3L2
RPOB_STRA1
Transcriptase subunit beta
Streptococcus
MAGHEVQYGKHRTRRSFSRIKEVLDLPNLIEIQTDSFQDFLDAGLKEVFEDVLPISNFTDTMDLEFVGYELKEPKYTLEEARIHDASYSAPIFVTFRLVNKETGEIKTQEVFFGDFPIMTEMGTFIINGGERIIVSQLVRSPGVYFNDKVDKNGKVGYGSTVIPNRGAWLELETDAKDIAYTRIDRTRKIPFTTLVRALGFSGDDEIVDIFGDSELVRNTIEKDIHKNPSDSRTDEALKEIYERLRPGEPKTADSSRSLLVARFFDPRRYDLAAVGRYKINKKLNLKTRLLNQTIAENLVDGETGEILVEAGTVMTRDVIDSIAEHIDGDLNKFVYTPNDYAVVTEPVILQKFKVVAPTDPDRVVTIVGNSNPEDKVRALTPADILAEMSYFLNLAEGIGKVDDIDHLGNRRIRAVGELLANQFRIGLARMERNVRERMSVQDNEVLTPQQIINIRPVTAAVKEFFGSSQLSQFMDQHNPLSELSHKRRLSALGPGGLTRDRAGYEVRDVHYTHYGRMCPIETPEGPNIGLINNLSSFGHLNKYGFIQTPYRKVDRSTGAVTNEIVWLTADEEDEFTVAQANSKLNEDGTFAEEIVMGRHQGNNQEFPSSIVDFVDVSPKQVVAVATACIPFLENDDSNRALMGANMQRQAVPLIDPKAPYVGTGMEYQAAHDSGAAVIAKHDGRVIFSDAEKVEVRREDGSLDVYHVQKFRRSNSGTAYNQRTLVKVGDLVEKGDFIADGPSMENGEMALGQNPVVAYMTWEGYNFEDAVIMSERLVKEDVYTSVHLEEFESETRDTKLGPEEITREIPNVGEDSLRDLDEMGIIRIGAEVKEGDILVGKVTPKGEKDLSAEERLLHAIFGDKSREVRDTSLRVPHGGDGVVRDVKIFTRANGDELQSGVNMLVRVYIAQKRKIKVGDKMAGRHGNKGVVSRIVPVEDMPYLPDGTPVDIMLNPLGVPSRMNIGQVMELHLGMAARNLGIHIATPVFDGASSEDLWETVQEAGMDSDAKTVLYDGRTGEPFDNRVSVGVMYMIKLHHMVDDKLHARSVGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGASNVLQEILTYKSDDVTGRLKAYEAITKGKPIPKPGVPESFRVLVKELQSLGLDMRVLDEDDNEVELRDLDEGEDDDVMHVDDLEKARVKQEAEEKQAEQVSEVVQED
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q3K3L2
A6T4I7
RSMA_KLEP7
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Klebsiella
MNNRVHQGHLARKRFGQNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIELDRDLAARLQTHPFLGPKLTIYQQDAMTMNFGELAEKMGQPLRVFGNLPYNISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQYYCQVIPVLEVPPSAFTPPPKVDSAVVRLVPHSTMPYPVKEIRVLSRITTEAFNQRRKTIRNSLGNLFSVEVLTELGIDPAMRAENISVAQYCLMANWLSDNLPTKES
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
A6T4I7
B5XQ71
MINC_KLEP3
Probable septum site-determining protein MinC
Klebsiella
MSNTPIELKGSSFTLSVVHLHDANPEVIRQALEDKIAQAPAFLRHAPVVVNIASVEEEVEWRAINEAIAATGLRIMGVSGCKIPRLKTEIDRAGIPLLTEGKEKAPRPAPSEPTPPPPPVANQITKTRLIDQPVRSGQRIYAPHCDLIVTNHVSAGAELIADGNIHVYGMMRGRALAGAGGDRDAQIFCTHLAAELVSIAGEYWLSDNIPAEFYGKAARLRLGESALTVQPLN
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
B5XQ71
Q83I04
RL19_TROW8
50S ribosomal protein L19
Tropheryma
MHALDALDALSIKADIPDFSPGDTVRVYVNITEGDRSRVQVFQGVVIARRGFGVRQTFTVRKISFQVGVERIFPLHSPSINRIEVVTKGSVRRAKLYYIRKLRGKKAKVKQKREL
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Q83I04
P0C0X3
TFB5_CANAL
RNA polymerase II transcription factor B subunit 5
Candida
MLVASKGVLVQCDPSIKALIIQIDSSSSGIILEELDETHLLIQHDKVNFVKSELNRLLSKNIYNPFEEE
Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.
P0C0X3
A1VT30
COAX_POLNA
Pantothenic acid kinase
Polaromonas
MTFLALDVGNTRLKWAQYDAPVVGAKLLAHGAVFLENIDRLAENDWHGMPEPSAILGCVVAGDAIKRRVAEQMEIWDVLPRWVHSSPQEAGLTNGYDHPARLGSDRWVAMIGAYHRLLARGIRKPCLVVMVGTAVTVEAIDASGKFLGGIILPGHGIMLRALESGTAGLHVPTGDVRDFPTNTSDALTSGGTFAIAGAVQRMVDNITRHCGEAPECIMTGGAAWKMAPSMSVKVELVETLIFDGLLEIASRRFKP
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
A1VT30
Q9QY17
PACN2_RAT
Syndapin-II
Rattus
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCGDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAVMSEAERVSELHLEVKASLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVDAAKKAHHTACKEEKLAVSREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKALKELDQTTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKGIYRELEQSIKAADAVEDLRWFRANHGPGMAMNWPQFEDEEWSADLNRTLSRREKKKAADGVTLTGINQTGDQSGQNKPSSNLSVPSNPAQSTQLQSSYNPFEDEDDTGSSVSEKEDIKAKNVSSYEKTQNYPADWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQEHDELSFKAGDELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEAIQ
Regulates the morphogenesis and endocytosis of caveolae . Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
Q9QY17
Q3SVD0
ISPG_NITWN
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Nitrobacter
MNKLESPSEIDVAGPSPRHKTTQVMVGNVAVGGGAPIVVQSMTNTDTADIEGTIAQVAALSRAGSEMVRMTVDRDEAAAAVPHIRDGLRKRGITTPLIGDFHYIGHKLLADHPSCAEALDKYRINPGNVGFKDKRDKQFTDIVETAIKYGKAVRIGANWGSLDQELLTHLMEENANSAAPLDARAVTREAMVQSALLSAKRAEEIGLPKTRMVLSAKVSAVQDLIAVYQTLASRSDYAIHLGLTEAGMGSKGIVASSAALGILLQQGIGDTIRISLTPEPGGDRTLEVQVAQELLQTMGFRTFVPLVAACPGCGRTTSTTFQELARSIQDFIRDEMPNWKTQYPGVEQLNVAVMGCIVNGPGESKHADIGISLPGTGEAPAAPVFVDGKKFKTLRGPAIAQDFKALVIDYIEQRYGDAAKARAEAVSAAE
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Q3SVD0
Q8DZK7
NADK_STRA5
ATP-dependent NAD kinase
Streptococcus
MTQMNFTDRATRVAIIANGKYQSKRVASKLFAAFKHDPDFYLSKKDPDIVISIGGDGMLLSAFHMYEKQLDKVRFVGVHTGHLGFYTDYRDFEVDTLINNLKNDKGEQISYPILKVTITLEDGRVIRARALNESTIKRIEKTMVADVVINQVVFERFRGDGILVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVYRTLGSSVIIPKKDAIEIVPKRVGVYTISIDNKTVHYKNVTKIEYSIDEKSINFVSTPSHTSFWERVNDAFIGEPEH
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Q8DZK7
Q46631
AMSA_ERWAM
Amylovoran biosynthesis membrane-associated protein AmsA
Erwinia
MKSKIEEPSANGGEAIRFELAHLLGQLLDHRWMIVAVSVLFTLMGTLYSLFATPIYSADAMVQVEQKNANTVLNDISQMMPNAQPASAAEIEIITSRMVLGKTVADLGLDVLVQQDHFPLIGAGLSRIIGQKAQQIAVSRLKVPTLWDKRELSVEVDGPDSYTVSKDGNELFKGKVGQFEQHGDVTMLVNSIEADAGTRFTVSKLNNLQAIKMISNNLVVADMGKDTGVLGLTYSGEDPVQISRVLDQVINNYLYQNIARKSEEAEKSIQFLAQQLPDVRAKLDQAEDKLNVFRRKHDSVDMSLEAKSALDSSVSIQTQLNALTFREAEVSQLFKKDHPTYRALLEKRQTLDEQQKQLNGKISQMPQTQQEIVRLTRDVQAGQEIYMQLLNRQQELNISKASTVGDVRIIDHAETAAKPVAPKSILIVAGSLILGLVVSVGLVLMKALFHHGIDNPEQLEELGLNVYASVPLSEWQRKKDQETLLKRKLDARTDPHNRLLALGNPTDLSIEAIRSLRTSLHFAMMDAQNNILMITGASPGIGKTFVCANLATLVAKTGEKVLFIDGDMRRGYTHELLGAESKTGLSDILSGKLPFNTDLVQRGDYGFDFIARGQVPPNPSELLMNSRMKELVHWASQNYDLVLIDTPPILAVTDASIIGKLAGTSLMVARFETNTVKEVEISYKRFIQNGIDIKGIILNAVVRKSANNYGYGYDYYDYSYQQGEKS
Involved in the biosynthesis of amylovoran which functions as a virulence factor.
Q46631
A5GQF7
NU3C_SYNR3
NDH-1 subunit 3
unclassified Synechococcus
MFVLPGYDAFLGFLLIAAAVPVLALITNAVLAPRSRQGERRLTYESGMEPVGGAWIQFNIRYYMFALVFVIFDVETVFLYPWAVAFHRLGLLAFIEALVFIAILVVALAYAWRKGALEWS
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.
A5GQF7
P19486
EF1A_THEAC
Elongation factor Tu
Thermoplasma
MASQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRKEAEQKGKATFEFAWVMDRFKEERERGVTIDLAHRKFETDKYYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGEGVMEQTREHAFLARTLGVPQMVVAINKMDATSPPYSEKRYNEVKADAEKLLRSIGFKDISFVPISGYKGDNVTKPSPNMPWYKGPTLLQALDAFKVPEKPINKPLRIPVEDVYSITGIGTVPVGRVETGVLKPGDKVIFLPADKQGDVKSIEMHHEPLQQAEPGDNIGFNVRGIAKNDIKRGDVCGHLDTPPTVVKAFTAQIIVLNHPSVIAPGYKPVFHVHTAQVACRIDEIVKTLNPKDGTTLKEKPDFIKNGDVAIVKVIPDKPLVIEKVSEIPQLGRFAVRDMGQTVAAGQCIDLEKR
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
P19486
Q96AJ1
CLUA1_HUMAN
Qilin
Homo
MSFRDLRNFTEMMRALGYPRHISMENFRTPNFGLVSEVLLWLVKRYEPQTDIPPDVDTEQDRVFFIKAIAQFMATKAHIKLNTKKLYQADGYAVKELLKITSVLYNAMKTKGMEGSEIVEEDVNKFKFDLGSKIADLKAARQLASEITSKGASLYDLLGMEVELREMRTEAIARPLEINETEKVMRIAIKEILTQVQKTKDLLNNVASDEANLEAKIEKRKLELERNRKRLETLQSVRPCFMDEYEKTEEELQKQYDTYLEKFQNLTYLEQQLEDHHRMEQERFEEAKNTLCLIQNKLKEEEKRLLKSGSNDDSDIDIQEDDESDSELEERRLPKPQTAMEMLMQGRPGKRIVGTMQGGDSDDNEDSEESEIDMEDDDDEDDDLEDESISLSPTKPNRRVRKSEPLDESDNDF
Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.
Q96AJ1
Q9SKJ5
CESAA_ARATH
Probable cellulose synthase A catalytic subunit 10 [UDP-forming]
Arabidopsis
MVAGSYRRYEFVRNRDDSDDGLKPLKDLNGQICQICGDDVGLTKTGNVFVACNECGFPLCQSCYEYERKDGSQCCPQCKARFRRHNGSPRVEVDEKEDDVNDIENEFDYTQGNNKARLPHRAEEFSSSSRHEESLPVSLLTHGHPVSGEIPTPDRNATLSPCIDPQLPGIYQLLLLPVRILDPSKDLNSYGLVNVDWKKRIQGWKLKQDKNMIHMTGKYHEGKGGEFEGTGSNGDELQMVDDARLPMSRVVHFPSARMTPYRIVIVLRLIILGVFLHYRTTHPVKDAYALWLTSVICEIWFAFSWLLDQFPKWYPINRETFLDRLALRYDRDGEPSQLAPVDVFVSTVDPMKEPPLVTANTVLSILAVDYPVDKVACYVSDDGSAMLTFEALSETAEFSKKWVPFCKKFNIEPRAPEFYFSQKIDYLKDKIQPSFVKERRAMKREYEEFKVRINILVAKAQKIPEDGWTMEDGTSWPGNNPRDHPGMIQVFLGHSGGLDTDGNELPRLIYVSREKRPGFQHHKKAGAMNALIRVSAVLTNGAYLLNVDCDHYFNNSKAIKEAMCFMMDPAIGKKCCYVQFPQRFDGIDLHDRYANRNTVFFDINLKGLDGIQGPVYVGTGCCFNRQALYGYDPVLTEEDLEPNIIVKSCFGSRKKGKSRKIPNYEDNRSIKRSDSNVPLFNMEDIDEDVEGYEDEMSLLVSQKRLEKRFGQSPVFIAATFMEQGGLPSTTNPLTLLKEAIHVISCGYEAKTDWGKEIGWIYGSVTEDILTGFKMHARGWISIYCVPSRPAFKGSAPINLSDRLNQVLRWALGSIEILLSRHCPIWYGYNGRLKLLERIAYINTIVYPITSIPLLAYCMLPAFCLITNTFIIPEISNLASLCFMLLFASIYASAILELKWSDVALEDWWRNEQFWVIGGTSAHLFAVFQGLLKVFAGIDTNFTVTSKASDEDGDFAELYVFKWTSLLIPPTTILLVNLVGIVAGVSYAINSGYQSWGPLMGKLLFAFWVVAHLYPFLKGLLGRQNRTPTIVIVWSALLASIFSLLWVRINPFVSTTGVMSNSFMGE
Probable catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation.
Q9SKJ5
Q133W8
MRAY_RHOPS
UDP-MurNAc-pentapeptide phosphotransferase
Rhodopseudomonas
MLYWLIDLSSSIPAFNVFRYITFRTGGAVVTGALFVFLCGPWIINNLRLRQGKGQPIRSDGPQSHLVTKKGTPTMGGLMILSGLTVGTVLWANPVNPYVWIVLAVTLGFGFVGFYDDYMKVTKQTHAGISGRTRLLIEFAIAGAACFALVWLGRSSLSSSLVIPFFKEVVLNLGWYFVIFGAFVIVGAGNAVNLTDGLDGLAIVPVMIAAASFGLIAYLAGNAVFADYLQINYVAGTGELAVLCGALLGAGLGFLWFNAPPASIFMGDTGSLALGGMLGSIAVAVKHEIVLAVIGGLFVLEAVSVIVQVASFKLTGKRVFRMAPIHHHFEQKGWTEPQIVIRFWIIAVMLALAGLATLKLR
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.
Q133W8
Q04806
GTO3_YEAST
Glutathione S-transferase omega-like 3
Saccharomyces
MSEKSASNNKAEFKRQSSPFREIISADHPIYKPAKGRYWLYVALPCPWAQRTLITRALKGLAPIIGCSVAHWHLDDKGWRFLEEGDGKTNERHWFDIAGGISSVNLNTSTPVANIPNNAHRLLVDGTDEPHYGYKRLSDFYFKTKPDYKGRFTVPVLWDLETCTIVNNESSDIIGIMNSAAFDEFVGEEYRQVRLVPRSLEAQITEFNSWVYDKINNGVYKAGFAECAEVYEREVTSLFQYLDKLENLLDKKYTDLEAEYGKNNKDKILDRYFAIGDTLTEADVRLYPTIVRFDVVYHQHFKCNLATIRDDYSRIHTWLKNIYWRHEAFQRTTDFTHIKLGYTRSQPRVNPIGITPLGPKPDIRPP
Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1-chloro-2,4-dinitrobenzene (CDNB).
Q04806
Q6XGD4
CAPE_ECOLX
Patatin-like phospholipase
Escherichia
MTYSVSPSSLLTEYGNDNICRVLALDGGGAKGFYTLGVLKEIEAMLGCPLYKRFDLVFGTSTGAIIAALIALGYEVDQIHALYTEHVPRVMSSRSAAARTMALQDLAKEVFQDKTFEDVLMGIGIVATRWMTERPMIFKGNVVQAHGRKGTFSPGFGVSIADAVQASCSAYPFFERKVIVTAAGDKVELIDGGYCANNPTLFAIADATVALKKDHKDIRVINVGVGIYPEPKPGLLMRIAKKWLAVQLLQKTLEINTQSMDQLRDILFKDIPTIRISDTFERPEMATDLLEYNLDKLNTLRQRGRESFGAREAQLREFLI
Phospholipase that is activated upon binding to the cyclic dinucleotide (CDN) second messenger 3',3'-cyclic UMP-AMP (3',3'-cUAMP).
Q6XGD4
Q56K04
CRIP1_BOVIN
Cysteine-rich protein 1
Bos
MPKCPKCSKEVYFAERVTSLGKDWHRPCLKCEKCGKTLTSGGHAEHEGKPYCNHPCYAAMFGPKGFGRGGAESHTFK
Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein.
Q56K04
B2VGW6
ARGR_ERWT9
Arginine repressor
Erwinia
MRNSSKQEDLIKAFKALLKEEKFSSQGEIVNALQEEGFENINQSKVSRMLTKFGAVRTRNAKMEMVYCLPAELGVPTTTSPLKNLVLDIDFNDALVVIHTSPGAAQLIARLLDSLGKAEGILGTIAGDDTIFITPARSFTVKQLHDAILVLFEQEL
Regulates arginine biosynthesis genes.
B2VGW6
P0C2B4
PEPO_LACLC
Endopeptidase O
Lactococcus
MTRIQDDLFATVNAEWLENAEIPADKPRISAFDELVLKNEKNLAKDLADLSQNLPTDNPELLEAIKFYNKAGDWQAREKADFSAVKNELAKVETLNTFEDFKNNLTQLVFHSQAPLPFSFSVEPDMKDAIHYSLGFSGPGLILPDTTYYNDEHPRKKELLDFWAKNTSEILKTFDVENAEEIAKSALKFDALLVPSANTSEEWAKYAELYHPISTDSFVSKVKNLDLKSLIKDLVKTEPDKVIVYEDRFYESFDSLINEENWSLIKAWMLTKIARGATSFFNEDLRILGGAYGRFLSNVQEARSQEKHQLDLTESYFSQVIGLFYGKKYFGEAGKADVKRMVTAMIKVYQARLSKNEWLSQETAEKAIEKLDAITPFIGFPDKLPEIYSRLKTTSGSLYEDALKFDEILTARTFEKFSEDVDKTSWHMPAHMVNAYYSPDSNTIVFPAAILQAPFYSLEQSSSQNYGGIGTVIAHEISHAFDNNGAQFDKEGNLNKWWLDEDYEAFEEKQKEMIALFDGVETEAGPANGKLIVSENIADQGGITAALTAAKDEKDVDLKAFFSQWAKIWRMKASKEFQQMLLSMDFHAPAKLRANIPPTNLEEFYDTFDVKETDKMYRAPENRLKIW
Endopeptidase with broad substrate specificity for several oligopeptides.
P0C2B4
B0T8A6
LGT_CAUSK
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
unclassified Caulobacter
MIFPNIDPIVHIGPWALQWGPLALRWYALAYVVGILLGWRYAVMLVRDAKLWGGHKPTATPLQIDDLVLWITLGIILGGRIGYVLFYMMLNEGQRAGLAEHPFDVFKIWEGGMSFHGGFLGVCAAIVLFARQQKIDMLKLGDLIAPVAPIGLFFGRCANFINGELWGRETTHPWGMIFCNETIQKANQGGCPAGHLPRHPSQLYEAALEGVLLFLILNFAAHKLKWLQRRGALVATFLICYGLFRVSLEGVRNPDHGMPNFPLGLTMGMILSIPMLAVGVWLLWRALREPVPPPLAEDHEPA
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
B0T8A6
Q2MY55
PATD3_SOLTU
Patatin group D-3
Solanum
MATTKSFLILIVMILATTSSTFASLEEMVTVLSIDGGGIKGIIPGTILEFLEGQLQKMDNNADARLADYFDVIGGTSTGGLLTSMITTPNENNRPFAAANEIVPFFFEHGPHIFNSSTGQFFGPKYDGKYLMQVLQENLGETRVHQALTEVAISSLDIKTNKPVIFTKSNLAKSPELDAKMYDICYSTAAAPTYFPPHYFTTNTINGDKYEFNLVDGAVATVADPALLSISVATRLAEKDPAFASIRSLNYKKMLLLSLGTGTTSEFDKTYTAEETAKWGAIQWMLVIQRMTDAASSYMTDYYLSTVFQAQNSQKNYLRVQENALTGTTTEMDDASEANMESLVQVGENLLKKPVSKDNPETYEEALKRFAKLLSDRKKLRANKASY
Probable lipolytic acyl hydrolase (LAH), an activity which is thought to be involved in the response of tubers to pathogens.
Q2MY55
Q0THN1
ASR_ECOL5
Acid shock protein
Escherichia
MKKVLALVVAAAMGLSSAAFAAETATTPAPTATTTKAAPAKTTHHKKQHKAAPAQKAQAAKKHHKNAKAEQKAPEQKAQAAKKHAKKHSHQQPAKPAAQPAA
Required for growth and/or survival at acidic conditions.
Q0THN1
Q1QV43
SYS_CHRSD
Seryl-tRNA(Ser/Sec) synthetase
Chromohalobacter
MLDPKLLRSDLPLVAERLARRGFTLDTARLEALESRRRELQTETERLQNERNTRSKAIGQAKASGEDIQPLLDEVSDLGERLDAAKARLAEVQAEWDESVAALPNLPHDSVPQGLDEADNVELHRWGTPGTFDFEVRDHVDLGAKFGYLDFEMAAKLTGSRFAVMRGPIARLHRALAQFMLDKQTREHGYEECYVPYIVNDASLTGTGQLPKFGEDLFKLEGDHDFYLIPTAEVPLTNIAREQIFTPAELPLKLTAHTPCFRSEAGAYGRDTRGMIRQHQFDKVEMVQIVDPATSYDALESMRGHAEAILQALELPYRVVTLCAGDMGFGAAKTYDLEVWLPSQETYREISSISNCEDFQARRMQARMRHPEQKKPQLVHTLNGSGLAVGRCLLAVLENCQQADGSIVIPEVLRGYMDGVERINA
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Q1QV43
O49741
GATA2_ARATH
GATA transcription factor 2
Arabidopsis
MDVYGLSSPDLLRIDDLLDFSNEDIFSASSSGGSTAATSSSSFPPPQNPSFHHHHLPSSADHHSFLHDICVPSDDAAHLEWLSQFVDDSFADFPANPLGGTMTSVKTETSFPGKPRSKRSRAPAPFAGTWSPMPLESEHQQLHSAAKFKPKKEQSGGGGGGGGRHQSSSSETTEGGGMRRCTHCASEKTPQWRTGPLGPKTLCNACGVRFKSGRLVPEYRPASSPTFVLTQHSNSHRKVMELRRQKEVMRQPQQVQLHHHHHPF
Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. May be involved in the regulation of some light-responsive genes.
O49741
O66131
GLPK_THETH
Glycerokinase
Thermus
MNQYMLAIDQGTTSSRAILFNQKGEIVHMAQKEFTQYFPQPGWVEHNANEIWGSVLAVIASVLSEAQVKPEQVAGIGITNQRETTVVWEKDTGNPIYNAIVWQSRQTAGICDELKAKGYDPLFRKKTGLLIDAYFSGTKVKWILDHVDGARERAERGELLFGTIDTWLIWKLSGGRVHVTDYSNASRTLMFNIHTLEWDDELLDILGVPKAMLPEVRPSSEVYAKTAPYHFFGVEVPIAGAAGDQQAALFGQACFTEGMAKNTYGTGCFMLMNTGEKAVASKHGLLTTIAWGIDGKVEYALEGSIFVAGSAIQWLRDGLRMIKTAADSETYAEKVESTDGVYVVPAFIGLGTPYWDSEVRGAVFGLTRGTTKEHFIRATLESLAYQTKDVLAVMEADSGISLTTLRVDGGAVKNNFLMQFQSDLLAVPVERPVVNETTALGAAYLAGLAVGYWNSRDDIAAQWQLERRFEPKMDDDKRTMLYDGWKKAVRAAMAFK
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
O66131
B7GH89
ISPG_ANOFW
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Anoxybacillus
MSEIIHRSKTRPVRVGNITIGGNNEVVIQSMTTTKTHDVDATVAQIHRLEEAGCQIVRVACPDERAADAIAEIKKRINIPLVVDIHFDYRLALKAIENGADKIRINPGNIGKREKVEAVVKAAKERGVPIRIGVNAGSLEKRILDKYGYPTADGMVESALHHIRILEDLDFQDIIVSLKASDVRLAIEAYEKAARAFDYPLHLGITESGTLFAGTVKSAAGLGAILSKGIGNTVRVSLSADPVEEVKVARELLKAFGLAANAATLISCPTCGRIEIDLISIANEIEEYIAQIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRHGKIVRKVPEETMVEELKKEIDKLAEEYASKGKQK
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
B7GH89
P0DMJ0
AMP4_HETSP
Antimicrobial peptide HsAp4
Heterometrus
MSRRRILILVLVTMLVKTMAGMESKWVETTYEIKKRSGTSEKERESGRLLGVVKRLIVGFRSPFRGRRAISEQT
Possesses antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as against the fungus C.tropicalis. Also possesses a relatively high hemolytic activity.
P0DMJ0
Q8NER1
TRPV1_HUMAN
Vanilloid receptor 1
Homo
MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFPVDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
Q8NER1
A8LE19
METK_FRASN
Methionine adenosyltransferase
unclassified Frankia
MATRLFTSESVTEGHPDKIADQVSDSILDAMLKDDPKSRVAVETMITTGQVHVAGEVTTKTYVDIASVVRERILEIGYDSSKKGFDGASCGVSVSIGSQSPDIAQGVDTAHEARVEGSTEDDLDRQGAGDQGLMFGFACDETPELMPLPIALAHRLARRLSAVRKDGQVGYLRPDGKTQVTIEYEDGKPVRLDTVVVSSQHAADIDLDTLLAPDVAEYVVEPELALLEISTEGRRLLVNPTGRFEIGGPMGDAGLTGRKIIVDTYGGYARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLASRCEVQVAYAIGKAHPVGLFVETFGTGKVPDAQIQDAVTQVFDLRPAAIVRDLDLLRPIYAQTAAYGHFGRPELDFTWEATSRADALTAAVKG
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
A8LE19
Q5F6I7
NADA_NEIG1
Quinolinate synthase
Neisseria
MQTAARRSFDYDMPLIQTPTSACQIRQAWAKVADTPDHETAGRLKDEIKVLLKRKNAVLVAHYYVDPLIQDLALETGGCVGDSLEMARFGAEHEAGTLVVAGVRFMGESAKILCPEKTVLMPDLEAECSLDLGCPEEAFSAFCDQHPDRTVAVYANTSAAVKARADWVVTSSVALEIVSYLKSRGEKLIWGPDRHLGDYIRRETGADMLLWQGSCIVHNEFKGQELAALKAEHPDAVVLVHPESPQSVIELGDVVGSTSKLLKAAVSRPEKKFIVATDLGILHEMQKQAPDKEFIAAPTAGNGGSCKSCAFCPWMAMNSLGGIKHALTGGRNEILLDRKLGEAAKLPLQRMLDFAAGLKRGDVFNGMGPA
Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
Q5F6I7
Q0K9V9
ALR_CUPNH
Alanine racemase
Cupriavidus
MPRPIHAVIHQPALANNLDIIRGKAPESRIWAVVKANAYGHGIRRVFAALRGADGFGLLDLNEAVLLRDLGWQGPILLLEGFFQPQDVAVIEQYRLTTAIHCDEQLRMLESARAKGPLAIQLKLNTGMNRLGFHPAAYRTAWERARAMPCVGSIVHMTHFSDADSARGVAHQIEAFDAATANLPGEASLSNSAAVLWHPQAHRAWVRPGIILYGASPTGRDADIAGTGLQPAMSLHSELISVQDLQPGDTVGYGSLFTAERPMRIGVVACGYADGYPRHASGWGEQRAPVLVDGVRTELVGRVSMDMLCVDLTPCPKARVGSPVTLWGQGLPIDEVAQASGTVGYELMCALAPRVPTSVATITASDSAAPAVA
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
Q0K9V9
O75817
POP7_HUMAN
Ribonucleases P/MRP protein subunit POP7 homolog
Homo
MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQLARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANTSTVELVDELEPETDTREPLTRIRNNSAIHIRVFRVTPK
Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends . Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences .
O75817
A0A0G3F8Z3
TBO1_TIBOB
Omega-Tbo-IT1
Tibellus
MKKTFCFILILVCIVLKSVNAEEEDNFEESSLEMETARCASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM
Insect-specific toxin that probably acts as an inhibitor of presynaptic insect calcium channels, presumably Cav2 subtype. In vivo, induces immediate paralysis on insects, followed by death when high doses are injected.
A0A0G3F8Z3
F9UT68
LPDD_LACPL
Gallate decarboxylase subunit D
Lactiplantibacillus
MATFTTEQAGYQMQAILQVIGYDLLIVVTGGTNPHIGDVTTLTASTVPETVKFPSHDGRFHKDNFISERMAKRIQRYLAGSCTITAGIHVNQITKAQIAAAAPMTDDLSRQIISWLQAHPVQAEKPEYYGQDEQPR
Probably involved in tannin degradation, however the precise biochemical function in metabolism of gallate is unknown.
F9UT68
Q849R0
SEPB_PSEP1
Probable efflux pump membrane transporter SepB
Pseudomonas
MSRFFIDRPIFAWVLAIIAMLAGALSLTKMPISQYPNIAAPAVSIQVVYPGASAKTVQDTVVQVIEQQLNGLDGFRYMAAESASDGSMNIIVTFEQGTNPDIAQVQVQNKLQLATPRLPEEVQRQGLRVVKYQMNFFMVVGLVDKTGKMTNFDLGNLIASQLQDPISRINGVGDFLLFGSPYAMRIWLDPGKLNSYQLTPGDVAQAIREQNVQVSSGQLGGLPTRSGVQLNATVVGKTRMTTPAEFEEILVKVKADGSQVRVKDLGRVVLASENFAISAKYRGQDSAGLGLRLASGGNLLETVKAVKAELEKQKAYLPEGVEVIYPYDTSPVVEASIDSVVHTILEAVVLVFLVMFLFLQSLRATIIPTLAVPVVLLAAFALLPYFGISINVLTMYAMVLAIGLLVDDAIVVVENVERLMHDEGLSPLEATRKSMGQISGALVGIGMVLSAVFVPMAFFGGSAGIIYKQFAVTIVICMSLSVLVALIFTPALCATILKAPENDAHHEKKGFFGWFNRSFDRNSARFERGVGGILKHRGRYLLIFALITAGTGYLFTQIPKAFLPSEDQGLMMTEVRMPLNASAERTEVVLQEVKDYLLKEEGQLVDHVMTVNGFNFAGRGQNSGLVLVVLKDWAARQAAGEDVLSVAERANARFARIKDATVMAFVPPAVLEMGNAMGFDLYLQDNLGLGHESLMAARNQFLELAAENPSLRAVRPNGKDDEPQFQVKIDDEKARALQVSIASINDTMSAAWGSMYVNDFIDLGRVKRVYIQGVDSSRIAPEDFDKWYVRNALGEMVPFSAFATGEWIHGSPKLERYGGISAVNILGEPAPGFSTGDAMIAIAQIMQQLPSGIGLSYNGLSYEEIRTGDQAPMLYALTVLIVFLCLAALYESWSVPMSVILVVPLGIFGAVLATLWRGLEADVYFQVGLMTTVGLSAKNAILIIEFAKELYEKEGVPLVKAAIEAARLRLRPIIMTSLAFTFGVLPMARATGAGAGSQHSIATGVVGGMITATVLAVFFVPLFYVVVVKVFERNKKPAALAEEELA
Probable membrane transporter component of the SepABC efflux pump with unknown specificity.
Q849R0
Q0TKN7
ACPH_ECOL5
Acyl carrier protein phosphodiesterase
Escherichia
MNFLAHLHLAHLAESSLSGNLLADFVRGNPEESFPPDVVAGIHMHRRIDVLTDNLPEVREAREWFRNETRRVAPITLDVMWDHFLSRHWSQLSPDFPLQEFTCYAREQVMTILPDSPPRFINLNNYLWSERWLVRYRDMDFIQSVLNGMASRRPRLDALRDSWYDLDAHYDALETRFWQFYPRMMEQASRKAL
Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP.
Q0TKN7
B1L1I1
G6PI_CLOBM
Phosphohexose isomerase
Clostridium
MKNSLSLDLTKTKPYVEEHEIQYLESIIREMDNTLGKKTGPGNKFLGWMDLPINYNKEEFARIKKAAEKIKNTCDVFIVIGIGGSYLGSRAAIEMISNTFYNNLDKSQRKVPQIYFAGNNISSTYMADLLELVKDKDICVNVISKSGTTTEPAIAFRIFKELLENKYGKEGAKERIFATTDAAKGALRTLADSEGYETFVIPDDVGGRFSVLTPVGLLPIAASGIDIDEMMKGAADARQEYSSDNIEKNHVYRYVAVRNALYRKGKTTEMLVNFEPCLHYFGEWWKQLYGESEGKDGKGIFPAAADFSTDLHSMGQYIQEGLRNIFETFINVENPRKSIMIKEDKENLDGLNFLAEKDMDYVNHQALRGTVLAHNDGGVPAIVLNVPELSAYYFGQLVYFFEKACGISGYLQGVNPFDQPGVEAYKKNMFALLGKPGHEDMKATLEERLK
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
B1L1I1
Q43883
NIFB_TRIAZ
Radical SAM assemblase NifB
Trichormus
MTPPVTGSSVTESTPTKAKSGGCGCDTSTTVEMDEKLQERIAKHPCYSEEAHHHYARMHVAVAPACNIQCNYCNRKYDCANESRPGVVSELLTPEEAAHKVLVIAGKIPQMTVLGIAGPGDPLANPEKTFRTFELIADKAPDIKLCLSTNGLMLPEYVDRIKQLNIDHVTITLNTIDPEIGAQIYSWVHYKRRRYRGAEGARILLEKQMEGLQALREADILCKVNSVMIPGINDQHLVEVNKMIREQGAFLHNIMPLISAPEHGTHFGLTGQRGPSQKELKSVQDQCSGNMKMMRHCRQCRADAVGLLGEDRSQEFTKDKFLEMAPEYDFDKRQEVHEGIEKFRVELKVAKEKVLAGKEKTASNPKILVAIATKGGGLVNQHFGHAKEFQVYEVDGSEVRFVSHRKVDHYCQGGYGEEATFDNIVKTIADCKAVLVSKIGESPKEKLLQAGIQTVEAYDVIEKVALEFYEQWNKG
Involved in the biosynthesis of the iron-molybdenum cofactor (FeMo-co or M-cluster) found in the dinitrogenase enzyme of the nitrogenase complex in nitrogen-fixing microorganisms. NifB catalyzes the crucial step of radical SAM-dependent carbide insertion that occurs concomitant with the insertion of a 9th sulfur and the rearrangement/coupling of two [4Fe-4S] clusters into a [8Fe-9S-C] cluster, the precursor to the M-cluster.
Q43883
Q2P4Y6
PQQB_XANOM
Pyrroloquinoline quinone biosynthesis protein B
Xanthomonas
MRIIVLGSAAGGGHPQWNCHTPASLRAWQQADGAQRRTQASIAVSADGERWVLINASPDFRQQILATPALWPQQGLRHSPIKAVLLTSGEIDHIAGLLSMRESQPFALHASRRVLDLLAQNPIFDAVNPQYVSRQPFTLNAPLTVSGLQLTPFSVPGKVPLFMESRSGGDLAGSQEETLGLTIDDSQHRVHYIPGCAAMTDALRARLHGAELVFFDGTLWRDDEMVQLGISQKTGQRMGHMSIDGPEGTIAAFAPLNVARKIFIHLNTTNPVLNTQSPEFATARASGWEVAHDGLEIAL
May be involved in the transport of PQQ or its precursor to the periplasm.
Q2P4Y6
O54820
PAPS1_CAVPO
Adenylylsulfate 3'-phosphotransferase
Cavia
MELPGSLCKKAKLGHGAQSWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALGEHLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDACDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAESLPALQINKVDMQWVQVLAEGWATPLGGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATEEDKERLDGCTAFALIYEGRRVAILRNPEFFEHRKEERCARQWGTTCKSHPYIKMVMEQGDWLIGGDLQVLDRIYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHRQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGILNPESTVVAIFPSPMMYAGPTGVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYKPTHGAKVLTMAPGLITLEIVPFRVAAYNKRKKRMDYYDAEHHEDFEFISGTRMRRLAREGQKPPEGFMAPTAWAVLAEYYKALEKA
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells.
O54820
P60105
RL11_VIBVY
50S ribosomal protein L11
Vibrio
MAKKVEAYIKLQVAAGMANPSPPVGPALGQRGVNIMEFCKAFNAKTESMEKGLPVPVVITVYSDRSFTFVTKTPPAAVLLKKAAGIKSGSGRPNTEKVGTVTDAQIQEIAEAKAADMTGADIEAMKRSIAGTARSMGLVVEG
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
P60105
A1U126
RECR_MARN8
Recombination protein RecR
Marinobacter
MAFSPLVDELVESLRCLPGVGQKTAQRMAFHLLERGRSGGTRLAAALNHAMDGVRRCDSCQNFSDTEICQICEKPERRNGTLCVVESPSDLLAIEQAGDYKGSYFVLMGHLSPIDGVGPEEIGIERLLDRVRREGVTELILATNPTVEGEATAHYIADRLDGQNILITRLAHGIPVGGELGYVDGFTLTHAFRGRKPLSE
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
A1U126
P53545
GSC_CHICK
Homeobox protein goosecoid
Gallus
MPASMFSIDNILAARPRCKDSVLLPPSAPVVFPSLHGDSLYGAASDYGGFYSRAVAPGSALPAVGRSRLGYNNYYYGQLHVATSPVGPSCCGAVPPLGAQQCSCVPPAGYEGAGSVLMSPVPHQMLPYMNVGTLSRTELQLLNQLHCRRKRRHRTIFTDEQLEALENLFQETKYPDVGTREQLARKVHLREEKVEVWFKNRRAKWRRQKRSSSEESENAQKWNKASKTSPEKRQEDGKSDLDSDS
Involved in the development of the organizer region in the gastrula (Hensen node in chicken).
P53545
Q661E2
RL4_BORGP
50S ribosomal protein L4
Borreliella
MERKVFSKDGKEIGTINLDDRVFNIEISHGSIYNAIKNELSNLRVGTSSTKTRSEVRGSSKKPWKQKGTGRARVGTKRNPIWIGGGIALGPKPRDYSYRLPKKVKRLAFKSVLSLRAADENNFKVVENFNIESGKTKDLALIIKNFASFNGKVVILLGNDDQMIKRAGKNIRDLKILSFNKLRVVDLFYAKNLIALESAVNKLNEFYVK
Forms part of the polypeptide exit tunnel.
Q661E2
Q1Q8S2
RNPH_PSYCK
tRNA nucleotidyltransferase
Psychrobacter
MRIDNRELNQLRSISFERHYTKHAEGSVLVSFGDTKVLCTASVESGVPRWLKGKGKGWITAEYGMLPRATNTRNQREAARGKQSGRTQEIQRLIGRSLRAMIDLSKLGENTIYLDCDVLQADGGTRTASVTGAAIALIDALESIQKTKKLKADPLIGLVAAVSVGMKDGKAYLDLNYEEDASCDTDLNVVMTQKGEFIELQGTAEEKPFTRAQADDMLILAEKGIAELIAMQKTALGW
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
Q1Q8S2
P28635
METQ_ECOLI
D-methionine-binding lipoprotein MetQ
Escherichia
MAFKFKTFAAVGALIGSLALVGCGQDEKDPNHIKVGVIVGAEQQVAEVAQKVAKDKYGLDVELVTFNDYVLPNEALSKGDIDANAFQHKPYLDQQLKDRGYKLVAVGNTFVYPIAGYSKKIKSLDELQDGSQVAVPNDPTNLGRSLLLLQKVGLIKLKDGVGLLPTVLDVVENPKNLKIVELEAPQLPRSLDDAQIALAVINTTYASQIGLTPAKDGIFVEDKESPYVNLIVTREDNKDAENVKKFVQAYQSDEVYEAANKVFNGGAVKGW
This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system.
P28635
B8CNX5
CMOA_SHEPW
Carboxy-S-adenosyl-L-methionine synthase
Shewanella
MKSSQDDLYAKPYQQVSDFQFDNKVAGVFNDMIRRSVPGYGQIINTIGDLAQKYATPNSKIYDLGCSLGAATLSVRRRVEGRNCQIIAVDNSESMIERCKENLSAYVSETPVKLVCGDIRDIEIENASLVILNFTMQFLAPEHRQSLLKKIYDGLQPGGLLVLSEKLYFEQDKIQSTLDDLHLDFKRANGYSELEISQKRSSLEHVMKPDTLEQHKIRIKQQGFSQFSVWFQCFNFASMVAIK
Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).
B8CNX5
Q473Q7
UREF_CUPPJ
Urease accessory protein UreF
Cupriavidus
MTPLRQLISLLHLASPALPIGGFSYSQGLEAAIDIGCVRDADTAERWIRDSLLYVQAQCEAPLWLLLHRGWQAMDVDAVREWNGWFHATRETAELRLETEQMGWSLAKLVGQMGWGGDALREHLAVISPVCLPTAFAATCVALEIDEREGLAAYCFNWAENQVAAAIKAVPLGQVAGQHMLRRLHEAVLMTVDEAVQRAAETPPRLSTFSPMLGLLSSRHETQYSRLFRS
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
Q473Q7
Q4PSE6
LRX7_ARATH
Cell wall hydroxyproline-rich glycoprotein
Arabidopsis
MRIYQPTLLIFTTVVLLSISAVAPGGSRQLLYTRDDPITIPPYLIFENVRLERAYVALQAWKRAMISDPWNLTTNWFGSRVCDYNGVVCSESLDDPLVKTVSGVDLNQGDIAGHLPEELGLLTDIALFHVNSNRFCGTLPVGFSQLSLLFELDLSNNRFAGKFPEVVIGLPKLKYLDLRYNEFEGELPESLFDKDLDALFLNSNRFRSKIPVNMGNSPVSVLVLASNRFEGCIPPSFGKMGKTLNEIILMDNGLQSCIPNDMGLLQNVTVLDISYNWLVGELPKSMGQMENLEVLNVERNMLSGLIPDELCSLEKLRDFRYGSNYFTGEPATCRYLENYNYTMNCFKDVRDQRSMMECKMFLSKPVDCDSFKCSPGSSCFSPPPSQISPSSQPLAPAPSPTSPPLSTPPPARPCPPVYSPPPPPPLSLAPSMN
Modulates cell morphogenesis by regulating cell wall formation and assembly, and/or growth polarization.
Q4PSE6
Q66HD3
NASP_RAT
Nuclear autoantigenic sperm protein
Rattus
MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAEGQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIPGLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETSEDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLSGQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSETKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANEETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSGNEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Q66HD3
A5GJG7
ACCA_SYNPW
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
unclassified Synechococcus
MPRRPLLEFEKPLVELEQQIEQIRQRARDSEVDVSPQLHQLETLAARRREEIFKSLTPAQKIQVARHPHRPSTLDYIQMLCDDWVELHGDRRGSDDQALIGGIGRLGDRAVLLIGHQKGRDTKENVARNFGMATPGGYRKALRLMDHANRFGLPILSFIDTPGAYAGLLAEEQGQGEAIAVNLREMFRFRVPIIATVIGEGGSGGALGIGVADKLLMFEHSVYTVASPEACASILWRDAGKASEAASALKITGPDLLSLGVVDEVLPEPVGGNHWAPLEAGEILKEALTRNLEGLLQLSEDALREQRYRKFRAMGQFLDDLSPEALMAE
Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.
A5GJG7
A8AF95
FLIT_CITK8
Flagellar protein FliT
Citrobacter
MTNFIPSLTDWHALHALSITMLDLAHSGKWDELIEQEMNYVQLVEGIARNPISPGNTFLINQAKEILNAVLRNEAELKTLLQHRMEELRQLIDQTGKQQSVSTTYGNLAGNILFPSNLNQ
Dual-function protein that regulates the transcription of class 2 flagellar operons and that also acts as an export chaperone for the filament-capping protein FliD. As a transcriptional regulator, acts as an anti-FlhDC factor; it directly binds FlhC, thus inhibiting the binding of the FlhC/FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus.
A8AF95
A6VH00
RS8_METM7
30S ribosomal protein S8
Methanococcus
MSLMDPLANALNHVSNCESVGKNVAYLKPASKLIGRVLNVMQDQGYIGNFEYIEDGKAGVYKVDLIGQINKCGAVKPRFAVKNHDFEKFEKRYLPAKGFGLLIVSTPKGLMTHDEARNAGVGGRLISYIY
One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.
A6VH00
B7NEP6
SELA_ECOLU
Selenocysteinyl-tRNA(Sec) synthase
Escherichia
MTTETRSLYSQLPAIDRLLRDSSFLSLRDTYGHTRVVELLRQMLDEAREVIRDSQTLPAWCENWAQEVDARLTKEAQSALRPVINLTGTVLHTNLGRALQAEAAVEAVAQAMRSPVTLEYDLDDAGRGHRDRALAQLLCRITGAEDACIVNNNAAAVLLMLAATASGKEVVVSRGELVEIGGAFRIPDVMRQAGCTLHEVGTTNRTHANDYRQAVNENTALLMKVHTSNYSIQGFTKAIDEAELVALGKELDIPVVTDLGSGSLVDLSQYGLPKEPMPQELIAAGVSLVSFSGDKLLGGPQAGIIVGKKEMIARLQSHPLKRALRADKMTLAALEATVRLYLHPEALSEKLPTLRLLTRSAEVIQIQAQRLQAPLAAHYGAEFAVQVMPCLSQIGSGSLPVDRLPSAALTFTPHDGRGSHLESLAARWRELPVPVIGRIYDGRLWLDLRCLEDEQRFLEMLLK
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
B7NEP6
Q137A8
QUEA_RHOPS
Queuosine biosynthesis protein QueA
Rhodopseudomonas
MRTELFDFDLPASSIALRPVSPRDAARMLVVRPGATLEDRAVRDLPALLQPGDQLVVNDTRVIAAQLTGRRIGRATEPRIEATLIKRLDGSRWQALVKPAKKLAEGDVVRFGHDGRVCLLGHLDATVEAKGDAGEVTLAFTFHGPALDQAIAELGATPLPPYIASKRTPDDQDAADYQTMFAANEGAVAAPTAGLHFTPELDAALKARGVTLHRLTLHVGAGTFLPVKVDDTAEHKMHAEWGTISEATADALNAARAQGGRIVAVGTTSLRLLESAAREDGTIAPFADETAIFITPGYRFRAVDALMTNFHLPRSTLFMLVSAFCGLETMQAAYRHAIDSGYRFYSYGDASLLFREPASR
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Q137A8
Q8TRS3
KAD_METAC
Adenylate monophosphate kinase
Methanosarcina
MNIILFGPPGAGKGTQAKKLVDFYGIPQISTGDILRANVREGTELGLAAKAYMDKGELVPDQVLIGIIKNRLNEADCEKGFILDGYPRTVPQADALEAILDEIEKPIDVVLNLEVPDEVLVGRISGRLMCKCGASYHIISNPPKKDNVCDICGGEVFQRADDTAEAVQNRLDVYKKQTQPLINYYKEKGILVTLDGTKEIDVVFEDLKAILAKFA
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Q8TRS3
C6E585
APT_GEOSM
Adenine phosphoribosyltransferase
unclassified Geobacter
MEDLKSIIRNIPDFPKKGILFKDITTLLGDAKSFQRMVDLLSHRYVGQKIDKVVGVEARGFIIGAALAYKLGAGIVLVRKPGKLPSQTRSKTYDLEYGTDTLEIHTDAFNKGDRVLIADDLLATGGTMAAVVDLISSMDVELVECCFMAELEFLEGGKKLPEGKVFSLLKF
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
C6E585
Q0DIV0
HEMH2_ORYSJ
Protoheme ferro-lyase 2
Oryza sativa
MWSSSQASTRGVIEVGRVEAGPSHFPKRPAPRNSSRVNLSRTYAIKSCSVSSRTGLCLGQCYHKKSSACKCKLGWSSQPLSSLRHHLRVHSSASEAVLTSQSDFTKLLVGNEKIGVLLLNLGGPETLDDVQPFLFNLFADPDIIRLPRLFRFLQKPLAQFISVVRAPKSKEGYASIGGGSPLRQITDAQAEALRKALCDKDIPAKVYVGMRYWHPFTEEAIEQIKRDGITKLVVLPLYPQFSISTSGSSLRLLEGIFREDEYLVNMQHTVIPSWYQREGYIKAMATLIEKELRTFSEPQKVMIFFSAHGVPLAYVEEAGDPYKAEMEECVDLIMEELEKRGITNSCTLAYQSRVGPVEWLRPYTDETIIELGQKGVKSLLAVPISFVSEHIETLEEIDVEYKELALESGIKHWGRVPALGCEPTFITDLADAVIESLPYVGAMAVSNLEARQPLVPLGSVEELLAAYDSKRDELPPPVTVWEWGWTKSAETWNGRAAMLAVLALLVLEVTTGEGFLHQWGILPLFH
Catalyzes the ferrous insertion into protoporphyrin IX.
Q0DIV0
Q6G5A8
COAE_BARHE
Dephosphocoenzyme A kinase
Bartonella
MKIIGLTGSIAMGKSTVADFFRQAGISVFSADEAVYKLYKSEPTLSLIEYKFPGVFENGKVNRQKLSEILINDNEKLQTLEKIIHPLVQEKEKKFIDTARQQGEKLVVLDIPLLLETKGEKRVDSVVVVSAPLAIQKERAMIRQNMSEKKFAFINGRQMSDEKKRARADFIIDTGKDLENTREQVLFVIKSLLKN
Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.
Q6G5A8
A3MRU1
RL11_BURM7
50S ribosomal protein L11
pseudomallei group
MAKKIVGFIKLQIPAGKANPSPPVGPALGQRGLNIMEFCKAFNAQTQGMEPGLPVPVVITAYADKSFTFVMKTPPATVLIKKAAKVDKGSSKPHTDKVGKITRAQAEEIAKTKMPDLTAADLDAAVRTIAGSARSMGITVEGV
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
A3MRU1
Q5RDJ2
ZMYM2_PONAB
Zinc finger protein 198
Pongo
MDTSSVGGLELTDQTPVLLGSTAMATSLTNVGNSFSGPANPLVSRSNKFQNSSVEDDDDVVFIEPVQPPPPSVPVVADQRTITFTSSKNEELQGNDSKITPSSKELASQKGSVSETIVIDDEEDMETNQGQEKNSSNFIERRPPETKNRTNDVDFSTSSFSRSKVNAGMGNSGITTEPDSEIQIANVTTLETGVSSVNDGQLENTDGRDMNLMITHVTSLQNTNLGDVSNGLQSSNFGVNIQTYTPSLTSQTKTGVGPFNPGRMNVAGDVFQNGESATHHNPDSWISQSASFPRNQKQPGVDSLSPVASLPKQIFQPSAQQQPTKPVKVTCANCKKPLQKGQTAYQRKGSAHLFCSTTCLSSFSHKPAPKKLCVMCKKDITTMKGTIVAQVDSSESFQEFCSTSCLSLYEDKQNPTKGALNKSRCTICGKLTEIRHEVSFKNMTHKLCSDHCFNRYRMANGLIMNCCEQCGEYLPSKGAGNNVLVIDGQQKRFCCQSCVSEYKQVGSHPSFLKEVRDHMQDSFLMQPEKYGKLTTCTGCRTQCRFFDMTQCIGPNGYMEPYCSTACMNSHKTKYAKSQSLGIICHFCKRNSLPQYQTTMPDGKLYNFCNSSCVAKFQALSMQSSPNGQFVAPSDIQLKCNYCKNSFCSKPEILEWENKVHQFCSKTCSDDYKKLHCIVTYCEYCQEEKTLHETVNFSGVKRPFCSEGCKLLYKQDFARRLGLRCVTCNYCSQLCKKGATKELDGVVRDFCSEDCCKKFQDWYYKAARCDCCKSQGTLKERVQWRGEMKHFCDQHCLLRFYCQQNEPNMTTQKGPENLHYDQGCQTSRTKMTGSAPPPSPTPNKEMKNKAVLCKPLTMTKATYCKPHMQTKSCQTDDTWKTEYVPVPIPVPVYIPVPMHMYSQNIPVPTTVPVPVPVPVFLPAPLDSSEKIPAAIEELKSKVSSDALDTELLTMTDMMSEDEGKTETTNINSVIIETDIIGSDLLKNSDPETQSSMPDVPYEPDLDIEIDFPRAAEELDMENEFLLPPVFGEEYEEQPRPRSKKKGAKRKAVSGYQSHDDSSDNSECSFPFKYTYGVNAWKHWVKTRQLDEDLLVLDELKSSKSVKLKEDLLSHTTAELNYGLAHFVNEIRRPNGENYAPDSIYYLCLGIQEYLCGSNRKDNIFIDPGYQTFEQELNKILRSWQPSILPDGSIFSRVEEDYLWRIKQLGSHSPVALLNTLFYFNTKYFGLKTVEQHLRLSFGTVFRHWKKNPLTMENKACLRYQVSSLCGTDNEDKITTGKRKHEDDEPVFEQIENTANPSRCPVKMFECYLSKSPQNLNQRMDVFYLQPECSSSTDSPVWYTSTSLDRNTLENMLVRVLLVKDIYDKDNYELDEDTD
May function as a transcription factor.
Q5RDJ2
O05137
MASZ_PSEFL
Malate synthase G
Pseudomonas
MTEHVQVGGLQVAKVLFDFVNNEAIPGTGITADQFWAGADKVIHDLAPKNKALLAKRDDFQARIDTWHQTHAGQAHDPVAYKAFLQDIGYLLPEAADFQASTQNVDDEIARMAGPQLVVPVMNARFALNASNARWGSLYDALYGTDAISEADGAEKGKGYNKVRGDKVIAFARAFLDEAAPLSAGSHVDSTGYKIADGKLIVSLKGGSNSGLRDDAQLIGFQGPAAQPIAILLKHNGLHFEIQIDASTPVGQTDAAGVKDVLMEAALTTIMDCEDSVAAVDADDKVVIYRNWLGLMKGDLAEEVAKGGKTFTRTMNPDRVYTGVDGQDVTLHGRSLLFVRNVGHLMTIDAILDKAGNEVPEGILDGLLTSLAAIHSLNGNSSRKNSRTGSVYIVKPKMHGPEEAAFTNELFGRIEDVLNLPRNTLKVGIMDEERRTTVNLKACIKAASERVVFINTGFLDRTGDEIHTSMEAGAMVRKAAMKTEKWIGAYENWNVDIGLSTGLQGRAQIGKGMWAMPDLMAAMLEQKIAHPLAGANTAWVPSPTAAALHALHYHKVDVFARQAELAKRERASVDDILTIPLAKNTDWSEEEIRNELDNNAQGILGYVVRWIDQGVGCSKVPDINDVGLMEDRATLRISSQHIANWLRHGVVTQDQVMESLKRMAPVVDRQNAGDALYRPLAPDFDSNIAFQAAVELVIEGTKQPNGYTEPVLHRKRREFKAKNGL
Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA.
O05137
O05940
DLDH_RHIEC
ORF-E3
Rhizobium
MAESYDVIIIGSGPGGYVAAIRASQLGLKTAIVEREHMGGICLNWGCIPTKALLRSAEVLDHANHFKDFGLVLEGSVKPDAKAVVGRSRAVSARLNAGVGFLMKKNKIDIIWGEAKLTKPGEIVVGKSSKPVVEPQHPLPKNVKGEGTYTAKHIIIATGARPRALPGIEPDGKLIWTYFEALKPDALPKSLIVMGSGAIGIEFASFYRSMGVDVTVVEVMPTIMPVEDAEITAIARKQLEKRGLKIFTSAKVTKVEKGAGSITAHVETSDGKVQQITADRMISAVGVQGNIENLGLEALGVKTDRGCVVADGYGKTNVAGIYAIGDVAGPPMLAHKAEHEGVVCVEKIAGLPNVHPTDKGKVPGCTYCNPQVASVGLTEAKAKELGRDIRVGRFSFAANGKAIALGEDQGMVKVIFDKKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTIFPHPTVSETMKEAVLDAYGRVLNA
Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.
O05940
Q0T8F9
CAIE_SHIF8
Carnitine operon protein CaiE
Shigella
MSYYAFEGLIPVVHPTAFVHPSAVLIGDVIVGAGVYIGPLASLRGDYGRLIVQAGANIQDGCIMHGYCDTDTIVGENGHIGHGAILHGCVIGRDALVGMNSVIMDGAVIGEESIVAAMSFVKAGFSGEKRQLLMGTPARAVRSVSDDELHWKRLNTKEYQDLVGRCHASLHETQPLRQMEENRPRLQGTTDVTPKR
Overproduction of CaiE stimulates the activity of CaiB and CaiD.
Q0T8F9
Q7ZAP3
PHNX_SALTY
Phosphonoacetaldehyde phosphonohydrolase
Salmonella
MNRIHAVILDWAGTTVDFGSFAPTQIFVEAFRQAFDVEITLAEARVPMGLGKWQHIEALGKLPAVDARWQAKFGRSMSAADIDAIYAAFMPLQIAKVVDFSSPIAGVIDTIAALRAEGIKIGSCSGYPRAVMERLVPAAAGHGYRPDHWVATDDLAAGGRPGPWMALQNVIALGIDAVAHCVKVDDAAPGISEGLNAGMWTVGLAVSGNEFGATWDAYQTMSKEDVAVRREHAASKLYAAGAHYVVDSLADLPGVIAHINARLAQGERP
Involved in phosphonate degradation.
Q7ZAP3
Q8IZ69
TRM2A_HUMAN
mRNA (uracil-5-)-methyltransferase TRMT2A
Homo
MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLYSYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAAERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPYAEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYRNKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTPYSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRASGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVLYTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNPRAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEMLILFERVEHPNGTGVLGPHSPPAQPTPGPPDNTLQETGTFPSS
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs . Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs . Also able to mediate the formation of 5-methyl-uridine in some mRNAs .
Q8IZ69
Q74CG7
PANC_GEOSL
Pantoate-activating enzyme
Geobacter
MRIIDSVADMQAFSRDARRSGKTIALVPTMGYLHDGHASLMREGRTRADILVVSIFVNPTQFGPNEDFTTYPRDLERDLQVAEAAGADVIFAPRADDMYPAGFQTYVDVEKVTLPLCGASRPGHFRGVTTVVAKLFNIVMPHTAFFGKKDFQQLAVIRRMVADLNMDLSIVGMPIIREPDGLAMSSRNAYLGPQERTNALCLNRSLAAARTLFTDGERSVARLRDTVLRILTEVPGAAIDYADFRDSETLEPVEAANEKTLLALAVKIGTTRLIDNCVLGEEQ
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q74CG7
A5CWV5
HTPG_VESOH
High temperature protein G
Candidatus Vesicomyosocius
MTIKQTHSFQTEVSQLLHLMIHSLYSNKEIFLRELISNASDAVDKLKFKSLSDDTLIEGKEALQIHIDVNKDANTITITDNGIGMSEVEVNKNIGTIANSGTKKFLKSLNETQAQDSNLIGQFGVGFYSSFIVSDKVEIITRKAGSKSKKGTKWASTGKGKYSIESIDRPDFGTSVILHIKKDEKEFLDDYRLRNIISKYSDHITVPIMMVKVSEDNKDIEYERINKANAFWAQDKQDLKQKDYDEFYKSLTYDLEAPLTQLHNRVEGNIDYTSLLFIPSKSPFDIWEPKRKGGIKLYAKRVFIMEDNEALMPLYLRFVKGVIDTADLSLNLSREILQDNKVIKAIRKASVKRILSVLEKMAKNKPEDYATFWQEFGMLMKEGVVEDTINKDKIAKLLRFTTNKSKNATQTVTLEHYIKNIQKDQKAIYYITAETYETAKGSPHLENFNQKNIEVLLLSDRVDEWMVSNFREFDGIQLKSIAKGNLEDFDSKEEKKAKEEVAKNFEIVIEKMQKILDSQVKEIKISSRLSESPSCLVADENEMGGNMERIMKSLGQDIPDTKPILEINPTHSLVKKLKTKIDEDLVKVLFDQAVLSEGGQLKDPAEFVKRINKLIN
Molecular chaperone. Has ATPase activity.
A5CWV5
Q62280
SSXT_MOUSE
Synovial sarcoma-associated Ss18-alpha
Mus
MSVAFAAPRQRGKGEITPAAIQKMLDENNHLIQCIMDYQNKGKASECSQYQQILHTNLVYLATIADSNQNMQSLLPAPPTQTMPMGPGGMSQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPSQLSMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMNMQPNQGPMMHQQPPSQQYNMPPGGAQHYQGQQAPMGLMGQVNQGSHMMGQRQMPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQSYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
Appears to function synergistically with RBM14 as a transcriptional coactivator. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.
Q62280
Q9ERJ6
GLHA_MERUN
Thyrotropin alpha chain
Meriones
MDYDRRYAAVILVVLSMFLHILHSLPDGDFIIQGCPECKLKENKYFSKGGAPIYQCMGCCFSRAYPTPARSKKTMLVPKNITSEATCCVAKSFTKATVMGNARVENHTECHCSTCYYHKS
Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways.
Q9ERJ6
O42837
MTA1_SORMK
Mating type protein SmtA-1
Sordaria
MSSVDQIVKTFAKLPEGERNAAVNAILAMMPPGPGPVRQIPEPVSQAPAPKKKVNGFMGFRSYYSPLFSQFPQKARSPFMTILWQHDPFHNEWDFMCSVYSSIRNYLEQSNAQREKKITLQYWLHFAVPVMGVLGRENYLPTLGWDLVTMPNGTIDLMRIAMPLFRKNLQPMNGLCLFTKCQEGGLQVDNQHLVIAKLSDPSYDMIWFNKRPHYQQRHAVQADSSELGVSALFPRNHAVAAEADDVATLQLPHWMQQGDFGTESGYSPQFETLLGSILENGNATSNDSYNMALAMDVPMMGFNGGA
Required for mating.
O42837