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Participants will be assigned by chance (like the flip of a coin) to receive one of three possible vaginal estrogen treatments - cream, tablets, or drug-eluting ring. |
* The main study tests and procedures include an initial visit in which the researchers will collect baseline information about participants and have participants complete a series of questionnaires. |
* There will then be 3 and 6 month follow-ups in which the researchers will have participants complete additional questionnaires and the researchers also assess whether participants are using the vaginal estrogen treatment that you were prescribed. |
If a participant is part of the microbiome cohort, they will also be asked to do the following: |
* a baseline visit in which urinary and vaginal specimens are collected to assess their baseline microbiome. The vaginal specimen collection will involve a q-tip swab inside the vagina; it is similar to a pap smear. |
* Finally, participants will have an imaging modality performed on their vagina called optical coherence tomography, which allows the researchers to assess the thickness of the vaginal walls and the blood vessel density. This imaging modality involves the insertion of a thin probe into the vagina to obtain the images o... |
* These tests will then be repeated at 6 months to assess if vaginal estrogen treatment causes changes to the vagina. conditions: Recurrent Urinary Tract Infection conditions: Hypoestrogenism studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESE... |
<|newrecord|> nctId: NCT06353256 id: 300012607 id: UL1TR003096 type: NIH link: https://reporter.nih.gov/quickSearch/UL1TR003096 id: 24POST1198805 type: OTHER_GRANT domain: American Heart Association briefTitle: A Community Health Worker Intervention to Address Preeclampsia acronym: AW2H overallStatus: NOT_YET_RECRUITIN... |
<|newrecord|> nctId: NCT06353243 id: STUDY00022901 briefTitle: Bilateral Infant Stimulation Study acronym: BLISS overallStatus: RECRUITING date: 2024-02-26 date: 2024-08 date: 2024-08 date: 2024-04-09 date: 2024-04-09 name: Oregon Health and Science University class: OTHER briefSummary: This study will investigate stre... |
<|newrecord|> nctId: NCT06353230 id: 0001 briefTitle: Comparison of Sclerotherapy Agents Used for Rectal Prolapse Treatment in Children acronym: Prolapse overallStatus: COMPLETED date: 2019-10-15 date: 2020-10-14 date: 2021-04-13 date: 2024-04-09 date: 2024-04-15 name: King Edward Medical University class: OTHER briefS... |
<|newrecord|> nctId: NCT06353217 id: IRB00419034 id: K23DK128572 type: NIH link: https://reporter.nih.gov/quickSearch/K23DK128572 briefTitle: Study of a Primary Care Hypoglycemia Prevention Program overallStatus: RECRUITING date: 2024-04-14 date: 2026-04-14 date: 2026-04-14 date: 2024-04-09 date: 2024-04-10 name: Johns... |
<|newrecord|> nctId: NCT06353204 id: 3325 briefTitle: Effectiveness of the Justice Diversion Halt-intervention overallStatus: RECRUITING date: 2024-02-01 date: 2027-07 date: 2027-07 date: 2024-04-09 date: 2024-04-09 name: Wetenschappelijk Onderzoek en Datacentrum class: OTHER_GOV name: Utrecht University name: Leiden U... |
<|newrecord|> nctId: NCT06353191 id: 19-002566 id: NCI-2024-00943 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 19-002566 type: OTHER domain: Mayo Clinic in Florida id: P30CA015083 type: NIH link: https://reporter.nih.gov/quickSearch/P30CA015083 id: R01HL169268 type: NIH link: https://reporter.nih.... |
<|newrecord|> nctId: NCT06353178 id: 20240314 briefTitle: Building Empowerment and Coping Outcomes for caNcer Patients, Survivors and Their Caregivers acronym: BEACON overallStatus: RECRUITING date: 2024-04-08 date: 2025-02-01 date: 2025-04-01 date: 2024-04-08 date: 2024-04-08 name: Color Health, Inc. class: INDUSTRY b... |
<|newrecord|> nctId: NCT06353165 id: CRO-2022-12-BAC-SNF-THA-YPZ briefTitle: Anti-bacterial Clinical Study on Teeth, Tongue, Cheek, Gum, and Saliva overallStatus: COMPLETED date: 2023-03-08 date: 2023-04-12 date: 2023-04-12 date: 2024-04-08 date: 2024-04-15 name: Colgate Palmolive class: INDUSTRY briefSummary: This 4-w... |
<|newrecord|> nctId: NCT06353152 id: GC506-507 briefTitle: Claudin 18.2-Targeted Chimeric Antigen Receptor T-cells for Gastric/Gastroesophageal Junction Adenocarcinoma overallStatus: RECRUITING date: 2023-11-17 date: 2025-11-16 date: 2025-11-16 date: 2024-04-08 date: 2024-04-08 name: Peking University class: OTHER name... |
<|newrecord|> nctId: NCT06353139 id: 90591 briefTitle: The Efficacy of Modified Olfactory Training for Patients With Olfactory Dysfunction overallStatus: RECRUITING date: 2023-07-01 date: 2024-12-31 date: 2024-12-31 date: 2024-04-08 date: 2024-04-08 name: Peking University Third Hospital class: OTHER briefSummary: The ... |
Is it possible that the device can treat olfactory disorders in adults? Compared to the conventional device, how efficient is the modified olfactory training device for treating patients with olfactory disfunction? conditions: Olfactory Impairment studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED intervention... |
<|newrecord|> nctId: NCT06353126 id: DTACESALT briefTitle: DEB-TACE Prior to Liver Transplantation in the Treatment of HCC overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-07-01 date: 2027-07-01 date: 2024-04-08 date: 2024-04-08 name: RenJi Hospital class: OTHER name: Boston Scientific Corporation briefSum... |
The primary outcome: Recurrence-free survival (RFS) The secondary outcome:1) Overall survival (OS)；2) Pathological response rate (Pathological Response); 3) Proportion of patients completing SALT; 4) Adverse events related to DEB-TACE. conditions: Liver Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA int... |
<|newrecord|> nctId: NCT06353113 id: HS-2023-0254 briefTitle: Feasibility of a Prenatal Yoga Mobile App in African American Pregnant Women overallStatus: RECRUITING date: 2024-04 date: 2024-07 date: 2024-09 date: 2024-04-08 date: 2024-04-08 name: San Diego State University class: OTHER briefSummary: The goal of this re... |
1. Is the Down Dog prenatal yoga app feasible for AA pregnant women? |
2. How does mental and physical health change after using the Down Dog app for 12-weeks? |
3. What cultural adaptations to the Down Dog app are needed? |
The study lasts for 12 weeks and participants are asked to: |
* do prenatal yoga with the app for at least 20 min/day, three days/week, from home |
* wear a Garmin Vivosmart 5 watch daily |
* complete four online surveys |
* complete an optional virtual interview |
This project aims to advance public health by contributing to a broader understanding of how prenatal yoga can support the health and well-being of AA pregnant women and promote optimal maternal and child health outcomes. conditions: Pregnancy Related conditions: Mental Health Issue conditions: Discrimination, Racial c... |
<|newrecord|> nctId: NCT06353100 id: 230602006 briefTitle: Chronic Pain in the General Population of Chile acronym: RDC overallStatus: ACTIVE_NOT_RECRUITING date: 2023-01-01 date: 2024-12-30 date: 2024-12-30 date: 2024-04-08 date: 2024-04-08 name: Pontificia Universidad Catolica de Chile class: OTHER name: Chilean Safe... |
The study objectives are as follows: |
1. Estimate the prevalence of CP and subtypes in the general population |
2. Explore the association between mental health indicators, perceived work stress and presence of CP in the population. |
3. Investigate the impact of CP (functional, occupational and social) among the subset of participants reporting CP |
4. Describe the use of management strategies in those who suffer from CP. conditions: Chronic Pain conditions: Migraine Disability conditions: Neuropathic Pain conditions: Fibromyalgia conditions: Depression, Anxiety conditions: Self Harm conditions: Insomnia conditions: Loneliness studyType: OBSERVATIONAL observationa... |
<|newrecord|> nctId: NCT06353087 id: B7451114 briefTitle: Abrocitinib Taiwan Treatment Pattern and Real World Study in ATopiC Dermatitis (ATTRACT Registry) acronym: ATTRACT overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-11-15 date: 2025-11-15 date: 2024-04-08 date: 2024-04-08 name: Pfizer class: INDUSTRY... |
<|newrecord|> nctId: NCT06353074 id: 1335cemre. briefTitle: Uterine Preservation With Acar's Atony Suture for Postpartum Uterine Hemorrhage overallStatus: COMPLETED date: 2021-01-01 date: 2023-11-30 date: 2023-11-30 date: 2024-04-08 date: 2024-04-08 name: Necmettin Erbakan University class: OTHER briefSummary: This stu... |
<|newrecord|> nctId: NCT06353061 id: LACC-MET briefTitle: Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2025-08-01 date: 2026-02-01 date: 2024-04-08 date: 2024-04-08 name: Peking Union Medical College Hospital class: OTHER briefS... |
<|newrecord|> nctId: NCT06353048 id: Soh-Med-24-02-04MS briefTitle: Short Term Radiological and Clinical Outcomes of Fixation of Schatzker II Tibial Plateau Fractures by Screws Only Versus Plate and Screws , Comparative Study overallStatus: RECRUITING date: 2024-02-10 date: 2025-02-15 date: 2025-02-15 date: 2024-04-08 ... |
Soft-tissue damage in fractures around the knee is of critical importance. The oedema and inflammation associated with the trauma can easily lead to local venous compromise, dermal hypoxia, and additional soft-tissue injury. This commonly leads to blistering of the skin and in some cases dermal and even muscle necrosis... |
Traditionally, initial radiograph diagnosis should include anteroposterior (AP), lateral and oblique views. But single radiographs do not allow an exact fragment identification and the initial fracture classification can change in 5% to 24% (mean 12%) of cases and treatment can change in up to 26% of cases after CT sca... |
Schatzer classification (published in 1974) will be used to complete understanding of the personality of these fracture which is the key element in decision making process when choosing the best possible treatment . |
In general ,tibial plateau fracture are to be operated on , but the decision whether to be operated or not on a specific fracture should be based on the fracture morphology ,soft tissues , the patient general condition and the expected limb axis and articular surface restoration. |
Usual indications for surgical treatment are : |
1. Intra-articular displacement of ⩾ 2 mm |
2. Metaphyseal -diaphyseal translation \> 1 cm |
3. Angular deformity more than 10 degree in the coronal or sagittal view |
4. Open fracture , compartment syndrome and associated ligament injury require repair. |
5. Associated fractures of the ipsilateral tibia or fibula |
Frequently the depressed articular fragments have to elevated back toward the knee , followed by fixation and sometimes supplemented with bone graft to fill any cancellous bone voids left beneath the joint surface after fracture reduction . |
We will evaluate treatment outcomes of closed reduction and percutaneous cannulated screw fixation for tibial plateau fractures versus open reduction and fixation by plate conditions: Tibial Plateau Fractures Schatzker Type II studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL prima... |
<|newrecord|> nctId: NCT06353035 id: NaturalResourcesIFinland id: 346136 type: OTHER_GRANT domain: Strategic Research Council Finland id: 346138 type: OTHER_GRANT domain: Strategic Research Council Finland briefTitle: Biodiversity Interventions for Well-Being acronym: BIWE overallStatus: ACTIVE_NOT_RECRUITING date: 202... |
In Biodiversity interventions for well-being (BIWE), microbial biodiversity interventions are performed to increase biodiversity in urban built areas. Results from the intervention trials are combined with publicly available land cover and ecological data. These are analyzed from the viewpoint of shifts in ecosystems a... |
The investigators set up an intervention study in which urban private yards are rewilded with diverse vegetation and decaying deadwood and plant residuals. The investigators aim to evaluate the effect of rewilding, and yard management practices on commensal microbiome, cortisol levels and well-being and salivary cytoki... |
<|newrecord|> nctId: NCT06353022 id: RC23_0267 id: 2023-508310-41 type: EUDRACT_NUMBER briefTitle: Minimal Residual Disease-based Strategy With T-Cell Redirector After Treatment With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (D-VRd) in Newly Diagnosed Multiple Myeloma acronym: IFm2022-01 overallStatus: N... |
The patient population will consist of adults men and women at least 18 years to younger than 66 years of age, who meet eligibility criteria. conditions: Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 103 ty... |
<|newrecord|> nctId: NCT06353009 id: ICM 2021-2720 briefTitle: Effect of a Single Ultra-Processed Meal on Myocardial Endothelial Function Assessed With Positron Emission Tomography acronym: SUPPER overallStatus: COMPLETED date: 2020-08-20 date: 2023-04-28 date: 2023-04-28 date: 2024-04-08 date: 2024-04-08 name: Matthie... |
The proposed study is an open-label, randomized crossover clinical trial. Participants will be divided into 2 groups: half of the participants will consume a Mediterranean meal during the first experimental visit and an ultra-processed meal during the second, and vice versa for the other half. The order in which the me... |
This project will contribute to clarify the role of diet in the development and progression of coronary artery disease. The results obtained from this study may potentially demonstrate the harmful effect of ultra-processed foods, even in the short term, on coronary arteries. conditions: Myocardial Endothelial Function ... |
<|newrecord|> nctId: NCT06352996 id: Dentist Anas Kassas briefTitle: Three-Dimensional Assessment of Maxillary Canine Retraction With and Without Power Arm overallStatus: ACTIVE_NOT_RECRUITING date: 2023-06-09 date: 2024-03-09 date: 2024-07-30 date: 2024-04-08 date: 2024-04-08 name: Mansoura University class: OTHER bri... |
Materials and methods:Twenty patients with age range between 14 to 25 years. Before bonding, a hook will be attached to the canine bracket in one side only. Leveling and alignment then The first premolars will be extracted and mini-implant will be inserted. |
Canine retraction using nickel titanium closed coil spring will start in the same day of upper first premolar extraction. conditions: Power Arm Canine Retraction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR... |
<|newrecord|> nctId: NCT06352983 id: 2014/11 briefTitle: Zirconium Dioxide Fixed Dental Prosthesis. overallStatus: COMPLETED date: 2017-12-20 date: 2019-09-27 date: 2023-01-20 date: 2024-04-08 date: 2024-04-08 name: Malmö University class: OTHER briefSummary: The purpose of this clinical trial is to evaluate and compar... |
<|newrecord|> nctId: NCT06352970 id: LundU-2024 briefTitle: Effects of Tuberculosis Infection on Development and Function of the Placenta overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2027-12-31 date: 2024-04-08 date: 2024-04-08 name: Lund University class: OTHER name: Addis Ababa University... |
The main questions it aims to answer are: |
* Does TB infection affect the structure of the placenta? |
* Does TB infection affect the function of the placenta? |
Pregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection: |
* Pathological lesions of the placenta |
* Gene and protein expression patterns linked to pregnancy-related disorders |
* Infant outcome at birth and at 6 weeks after birth conditions: Pregnancy Related conditions: Tuberculosis Infection conditions: Placenta Diseases studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 500 type: ESTIMATED name: TB infection measure: Proportion of women with pathologica... |
<|newrecord|> nctId: NCT06352957 id: 23022022CERC briefTitle: Use of ETElcalcetidefor pReserving vitamiN K-dependent proteIn activiTY ITAlian Study acronym: ETERNITY-ITA overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-12-31 date: 2027-12-31 date: 2024-04-08 date: 2024-04-08 name: Istituto di Fisiologia Cl... |
The study will enroll 160 hemodialysis patients: 80 patients treated with Etelcalcetide and 80 age and sex matched patients treated with Calcitriol or vitamin D analogs. The treating nephrologist will base the target dose of Etelcalcetide on individual-level in order to achieve the KDIGO PTH target. In the Etelcalcetid... |
<|newrecord|> nctId: NCT06352944 id: AssiutMD briefTitle: Procalcitonin as a Marker of Severity of Non-cystic Fibrosis Bronchiectasis in Children overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-07 date: 2026-07 date: 2024-04-08 date: 2024-04-17 name: Assiut University class: OTHER briefSummary: The aim of th... |
<|newrecord|> nctId: NCT06352931 id: TCD & TCUS in infants briefTitle: Transcranial Ultrasound and Transcranial Doppler in Diagnosis and Detection of Outcome in Infants With Neurological Diseases overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-06-30 date: 2025-07-30 date: 2024-04-08 date: 2024-04-08 name:... |
<|newrecord|> nctId: NCT06352918 id: B.30.2.ATA.0.01.00/395 briefTitle: Peripheral Central Catheter (PICC) Care acronym: PICC overallStatus: COMPLETED date: 2023-05-01 date: 2023-11-30 date: 2023-12-31 date: 2024-04-08 date: 2024-04-08 name: Ataturk University class: OTHER briefSummary: Peripheral Central Catheter (PIC... |
Today, it is accepted that tactile stimuli, which have a pain-reducing effect on babies, should be used as a complementary treatment and care method. Palmar grasp reflex is one of the important tactile stimuli to reduce pain and provide comfort in babies. This research will be conducted to examine the effect of palmar ... |
<|newrecord|> nctId: NCT06352905 id: 2157711 briefTitle: Acute Effects of Whole Body Vibration for Individuals With Parkinson Disease overallStatus: RECRUITING date: 2022-09-01 date: 2025-04 date: 2025-04 date: 2024-04-08 date: 2024-04-08 name: Baylor University class: OTHER name: University of St. Augustine for Health... |
<|newrecord|> nctId: NCT06352892 id: 20210201 briefTitle: A Study to Evaluate AMG 133 in Chinese Participants With Obesity or Overweight overallStatus: NOT_YET_RECRUITING date: 2024-04-24 date: 2024-09-03 date: 2024-09-03 date: 2024-04-08 date: 2024-04-08 name: Amgen class: INDUSTRY briefSummary: The main objective of ... |
<|newrecord|> nctId: NCT06352879 id: 18-Al-KindyCM briefTitle: Prevalence, Types and Risk Factors of Urinary Incontinence Among Women in Baghdad, Iraq. overallStatus: RECRUITING date: 2024-03-01 date: 2024-05-31 date: 2024-06-15 date: 2024-04-08 date: 2024-04-08 name: Al-Kindy College of Medicine class: OTHER briefSumm... |
* What is the prevalence of incontinence among the targeted group? |
* What are the types of incontinence and what is the frequency of each type among the targeted group? |
* What is the effect of several risk factors on the occurrence and severity of urinary incontinence (including age, job, sexual activity, chronic constipation, chronic cough, parity, largest birth weight, and body mass index)? Participants will be asked to fill out a questionnaire consisting of the Arabic International... |
<|newrecord|> nctId: NCT06352866 id: CASE3A23 briefTitle: Siltuximab for Cytokine Release Syndrome Prophylaxis Prior to tx w/ Teclistamab in RRMM overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-04-01 date: 2025-12-01 date: 2024-04-08 date: 2024-04-16 name: Jack Khouri class: OTHER briefSummary: The purpos... |
Participants will receive a single dose of prophylactic siltuximab, 11 mg/kg, 2 hours prior to the administration of the first dose of teclistamab on day 1. There is no planned dose escalation of siltuximab, and teclistamab dosing will be done following the standard planned ramp-up. Participants will be hospitalized fo... |
<|newrecord|> nctId: NCT06352853 id: Diathermy and skin incision cs briefTitle: Scalpel Versus Diathermy in Transverse Abdominal Skin Incision During Cesarean Section overallStatus: COMPLETED date: 2022-04-01 date: 2022-09-01 date: 2022-10-01 date: 2024-04-08 date: 2024-04-09 name: Cairo University class: OTHER briefSu... |
<|newrecord|> nctId: NCT06352840 id: HUM00231526 id: 5K23HD099283-03 type: NIH link: https://reporter.nih.gov/quickSearch/5K23HD099283-03 briefTitle: Novel Web-based, Self-directed Intervention for Chronic Pelvic Pain overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-04 date: 2026-04 date: 2024-04-08 date: 202... |
The overall hypothesis is that patients with chronic pelvic pain that have access to the My Pelvic Plan program will demonstrate improvements in pain, physical function, and quality of life with this integrative self-management approach. conditions: Chronic Pelvic Pain conditions: Endometriosis studyType: INTERVENTIONA... |
<|newrecord|> nctId: NCT06352827 id: HUM00228948 id: 1K23DK134752-01 type: NIH link: https://reporter.nih.gov/quickSearch/1K23DK134752-01 briefTitle: Guideline to Implementation: A Rapid Clinical Care Pathway to Care for Patients Affected by Chronic Constipation overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 202... |
<|newrecord|> nctId: NCT06352814 id: 1977152 briefTitle: Activities-based Locomotor Training Program Versus Traditional Physical Therapy in Children With Cerebral Palsy overallStatus: RECRUITING date: 2024-03-08 date: 2027-05-30 date: 2027-05-30 date: 2024-04-08 date: 2024-04-08 name: Baylor University class: OTHER bri... |
<|newrecord|> nctId: NCT06352801 id: EA230530 briefTitle: Effectiveness of Self-Compassion Intervention on Enhancing Self-Compassion and Psychological Well-Being of Children With Attention Deficit/Hyperactivity Disorder overallStatus: RECRUITING date: 2023-12-28 date: 2026-05-31 date: 2026-05-31 date: 2024-04-08 date: ... |
The intervention program includes the following components: |
Participants will be randomly assigned to the self-compassion intervention group or the waitlist control group. The intervention group consists of two parts: children training session and parent group sessions. All children participants will complete a total of 6 training sessions, and each session will last around 90 ... |
To investigate the intervention effectiveness, children will be asked to complete a questionnaire assessing their levels of self-compassion, emotional regulation, as well as psychological well-being in terms of life satisfaction, positive and negative affect. Parents and teachers of participants will also be asked to c... |
Study Objectives: |
1. To investigate the underlying mechanism of the relationship between AD/HD traits and psychological well-being |
2. To explore the effectiveness of self-compassion intervention on enhancing self-compassion and psychological well-being of children with AD/HD in Hong Kong |
Hypotheses: |
1. AD/HD traits negatively predicts psychological well-being |
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