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3. Design: Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 clinical trial followed by an Open-Label Extension Treatment Period conditions: Autism Spectrum Disorder studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Main study(0\~1... |
Extension study(12\~24 weeks) Experimental: AST-001 Comparator: AST-001 primaryPurpose: TREATMENT masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 160 type: ESTIMATED name: AST-001 name: Placebo of AST-001 measure: K-VABS-II (Korean-Vineland ... |
<|newrecord|> nctId: NCT06333951 id: 20230167 briefTitle: AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) overallStatus: RECRUITING date: 2024-06-03 date: 2026-10-08 date: 2029-10-07 date: 2024-03-27 date: 2024-04-25 name: Am... |
<|newrecord|> nctId: NCT06333938 id: 01968 briefTitle: Veterans Enhanced Recovery Using Integrative Treatments Around Surgery acronym: VERITAS overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-12 date: 2025-06 date: 2024-03-27 date: 2024-03-27 name: Durham VA Medical Center class: FED briefSummary: The study a... |
<|newrecord|> nctId: NCT06333925 id: Pro00114183 briefTitle: Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study acronym: MISO-STIM overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-10-31 date: 2026-10-31 date: 2024-03-27 date: 2024-03-27 name: Duke University class: OTHER name: Misopho... |
Sixty adult participants with moderate to severe misophonia will be recruited and taught an emotion regulation skill and randomly assigned to receive one of two types of repetitive transcranial magnetic stimulation (rTMS). The study includes 9-10 visits: the remote screening visit(s), the initial MRI, the four neurosti... |
The study team member who will conduct the behavioral session will be kept blind to the type of neurostimulation the participant will receive. Participants will also be kept blinded to what neurostimulation they receive and their perception of what they received will be assessed at follow-up. The intervention provider ... |
Participants will only be told about the type of neurostimulation at the end of the study to protect against different expectations whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: High Frequency Repetitive Transcranial Magnetic Stimulation (HF rTMS) name: Sha... |
<|newrecord|> nctId: NCT06333912 id: ridgesplittingguided briefTitle: Accuracy of Guided Ridge Splitting With Simultaneous Implant Placement overallStatus: COMPLETED date: 2023-08-02 date: 2024-01-29 date: 2024-02-27 date: 2024-03-27 date: 2024-03-27 name: Alexandria University class: OTHER briefSummary: Assessing whet... |
<|newrecord|> nctId: NCT06333899 id: CONNECT2111 briefTitle: Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2027-09-01 date: 2034-09-01 date: 2024-03-27 date: 2024-03-27 name: Nationwide Children's Hospital class: OTHER name: Pfizer brief... |
<|newrecord|> nctId: NCT06333886 id: ciusss-nordmtl_ESG briefTitle: Use of Point-of-care Neuro-sacral Electrophysiology Following Spinal Cord Injury overallStatus: ACTIVE_NOT_RECRUITING date: 2024-03-18 date: 2028-12-31 date: 2028-12-31 date: 2024-03-27 date: 2024-03-27 name: Centre Integre Universitaire de Sante et Se... |
<|newrecord|> nctId: NCT06333873 id: P22-09 briefTitle: Impact of Age-related Macular Degeneration on Daily Living Activitie acronym: AMDAY overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2029-06 date: 2029-06 date: 2024-03-27 date: 2024-03-27 name: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts cl... |
<|newrecord|> nctId: NCT06333860 id: M24-541 briefTitle: A Study to Learn How Safe and Effective Risankizumab is When Compared to Deucravacitinib to Treat Participants With Moderate Plaque Psoriasis and Who Need to Try Systemic Treatment (Works Throughout the Whole Body) overallStatus: NOT_YET_RECRUITING date: 2024-05-... |
This study is designed to enroll 336 participants 18 years of age and older with have been diagnosed with moderate chronic plaque psoriasis for at least 6 months prior to Baseline (Day 1) and who have not previously been treated with a biologic treatment (natural substance that is made by using living cells in a labora... |
Participants will be administered subcutaneous (SC) treatment of risankizumab every 12 weeks for up to 44 weeks or provided deucravacitinib oral tablets to be taken once daily. |
There may be higher treatment burden for participants in this trial compared to their standard of care (due to study procedures). Participants will attend regular (weekly, monthly) visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking ... |
<|newrecord|> nctId: NCT06333847 id: K2023-059 briefTitle: Is Multimorbidity a Source of Non-response Bias in Patients With Spinal Pain? - A Pilot Study overallStatus: ENROLLING_BY_INVITATION date: 2023-06-01 date: 2024-04-20 date: 2024-04-20 date: 2024-03-27 date: 2024-03-27 name: Jacob Christiansen Gandløse class: OT... |
<|newrecord|> nctId: NCT06333834 id: Dosis Seriada de Alacramyn briefTitle: Assessment of the Efficacy of Scorpion Antivenom Therapy in a Dose-response Manner, in Patients With Scorpionism overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-08-01 date: 2024-08-30 date: 2024-03-27 date: 2024-03-27 name: Selene... |
<|newrecord|> nctId: NCT06333821 id: BPL-Nim-CC-3003 briefTitle: A Study of Nimotuzumab Plus Concurrent Chemoradiotherapy Sequential Maintenance Treatment for Cervical Carcinoma overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2030-04-01 date: 2030-04-01 date: 2024-03-27 date: 2024-03-27 name: Biotech Pharmaceu... |
The primary hypotheses are that nimotuzumab plus concurrent chemoradiotherapy sequential maintenance therapy is superior to placebo plus concurrent chemoradiotherapy with respect to progression-free survival. conditions: Cervical Cancer studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: ... |
<|newrecord|> nctId: NCT06333808 id: GS-US-621-6290 id: 2023-510022-33 type: OTHER domain: European Medicines Agency briefTitle: Study to Compare Bictegravir/Lenacapavir Versus Current Therapy in People With HIV-1 Who Are Successfully Treated With Biktarvy acronym: ARTISTRY-2 overallStatus: RECRUITING date: 2024-03-25 ... |
The primary objective of this study is to learn how effective it is to switch to BIC/LEN FDC tablets versus continuing on B/F/TAF FDC tablets in virologically suppressed PWH. conditions: HIV-1-infection studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescript... |
<|newrecord|> nctId: NCT06333795 id: 1-10-72-131-23 briefTitle: Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis acronym: FaeMiCue overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-01-31 date: 2025-12-31 date: 2024-03-27 date: 2024-03-27 name: University of Aarh... |
<|newrecord|> nctId: NCT06333782 id: 2023-EU-GEN-01 id: 2023-A02012-43 type: OTHER domain: ANSM briefTitle: Evaluation of the Safety and Efficacy of Hyaluronic Acid Injection in Labia Majora Augmentation overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2025-07-01 date: 2025-07-01 date: 2024-03-27 date: 2024-04-... |
The primary objective is the evaluation of the safety of Genefill Contour®. The secondary objectives is effectivenes of the investigational device (improvement of patient´s symptoms, patient´s satisfaction, sexual function \& pain during injection). |
Participants will come to a total of 8 visits (including 2 phone calls) over a period of 12 months. Participants would be enrolled in Genefill Contour® or comparator group. |
An ancillary study would be conducted in a cohort of participants evaluating the increase in volume and distance between labia after HA injection conditions: Vulvar Atrophy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants would be randomi... |
<|newrecord|> nctId: NCT06333769 id: CATIMOR briefTitle: A Phase II Multicenter Clinical Study of Improved Short-course Radiotherapy Combined With CAPOX and PD-1 Monoclonal Antibody for Locally Advanced Mid-low Rectal Cancer overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-12-01 date: 2026-12-01 date: 2024... |
<|newrecord|> nctId: NCT06333756 id: YM110099E briefTitle: Effects of Muscle Strengthening and Fatigue on Activities in Cortex and Muscle acronym: YM110099E overallStatus: COMPLETED date: 2021-05-01 date: 2022-04-30 date: 2022-08-01 date: 2024-03-27 date: 2024-03-27 name: National Yang Ming University class: OTHER brie... |
Healthy participants receive cross education training of the elbow flexor (12 rep./set, 3sets, 60%MVC, 180°/s, eccentric).Maximal voluntary contraction, electroencephalogram and electromyogram will record during cross education tasks to determine the effects of cross education training on cortical network and muscle fu... |
<|newrecord|> nctId: NCT06333743 id: ZhuLan briefTitle: Laser Ablation in the Treatment of High-grade Cervical Lesions overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2026-05 date: 2024-03-27 date: 2024-03-27 name: Peking Union Medical College Hospital class: OTHER name: Obstetrics & Gynecology Hosp... |
<|newrecord|> nctId: NCT06333730 id: PMC briefTitle: Comparison of Anesthetic Efficacy of Mental Nerve Block Versus Inferior Alveolar Nerve Block in Mandibular Anterior Teeth and Premolars in Symptomatic Irreversible Pulpitis overallStatus: RECRUITING date: 2024-04-01 date: 2024-05-30 date: 2024-06-20 date: 2024-03-27 ... |
Study design: This randomized clinical trial study Number of participants: 96 participants which will be randomly divided into two groups: MINB and IANB. |
Inclusion criteria: Participants with mandibular premolars or lower anterior experiencing sharp and persistent pain in response to thermal stimuli and an electric pulp tester, as well as bleeding during access opening, will be included. |
Exclusion criteria: Participants with a medical history, allergies or contraindications to the local anesthetic, pregnant or breastfeeding women, those taking pain-affecting medication, or those experiencing pain in more than one tooth will be excluded. |
Both techniques will use 2% lidocaine and adrenaline 1:80,000. Age, gender, and the efficacy of anesthesia will be recorded in both groups. The chi-square test will be used for comparison. conditions: Symptomatic Irreversible Pulpitis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALL... |
<|newrecord|> nctId: NCT06333717 id: Dnr 2020-03709 briefTitle: Impact of Whole Grain Rye Bread on Health acronym: FBS overallStatus: COMPLETED date: 2021-03-03 date: 2021-03-03 date: 2021-11-05 date: 2024-03-27 date: 2024-03-27 name: Örebro University, Sweden class: OTHER briefSummary: This randomized controlled trial... |
<|newrecord|> nctId: NCT06333704 id: mRNA-1273-P924 briefTitle: Post-marketing Surveillance (PMS) Use-Result Surveillance With SPIKEVAX BIVALENT and SPIKEVAX X Injection. overallStatus: RECRUITING date: 2023-03-10 date: 2026-12-07 date: 2026-12-07 date: 2024-03-27 date: 2024-03-27 name: ModernaTX, Inc. class: INDUSTRY ... |
<|newrecord|> nctId: NCT06333691 id: Aya Mohammed briefTitle: Comparative Study Between Calcium Gluconate With Diosmin, Cabergoline and Cabergoline With Diosmin overallStatus: COMPLETED date: 2022-10-01 date: 2024-02-01 date: 2024-02-15 date: 2024-03-27 date: 2024-03-27 name: Minia University class: OTHER briefSummary:... |
Severe forms are also accompanied by electrolyte disturbances and cardiopulmonary, hepatic, renal, and hemoconcentration associated with increased thromboembolic risk. |
This syndrome is avoidable by the judicious use of gonadotropins and careful monitoring of stimulation regimens. conditions: Ovarian Hyperstimulation Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: PREVENTION masking: QUADRUPLE whoMasked: PARTICIPANT whoM... |
<|newrecord|> nctId: NCT06333678 id: 22-321 briefTitle: A Study Comparing Sotorasib With Durvalumab in People With Non-Small Cell Lung Cancer (NSCLC) overallStatus: RECRUITING date: 2024-03-20 date: 2027-03 date: 2027-03 date: 2024-03-27 date: 2024-03-27 name: Memorial Sloan Kettering Cancer Center class: OTHER name: A... |
<|newrecord|> nctId: NCT06333665 id: Wei G briefTitle: PPIO-007 Correlation Analysis of Type II Diabetes Mellitus on Short-term and Long-term Outcomes of Patients With Esophageal Squamous Cell Cancer Undergoing Minimally Invasive Esophagectomy overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-20 date: 2024-04-20 date:... |
<|newrecord|> nctId: NCT06333652 id: 22-009239 briefTitle: Ravulizumab in Pregnancies Complicated by Severe Hypertensive Disorders overallStatus: RECRUITING date: 2024-06-01 date: 2026-12-31 date: 2028-12-31 date: 2024-03-27 date: 2024-04-22 name: Mayo Clinic class: OTHER briefSummary: The researchers are testing a med... |
<|newrecord|> nctId: NCT06333639 id: 24Chirortho01 briefTitle: Implementing Virtual Reality in the Operating Room acronym: IRVABO overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-15 date: 2024-10-15 date: 2024-03-27 date: 2024-03-27 name: Centre Hospitalier Universitaire de Nice class: OTHER briefSummar... |
However, despite the clinical effectiveness of virtual reality in reducing pain and anxiety, there are very few feedback studies from patients on their experience of surgery and their satisfaction, especially in orthopaedics. |
The aim of this study is to demonstrate the superiority, during long awake orthopaedic surgery, of equipping the patient with a virtual reality headset, on patient satisfaction, compared with the same surgery without a headset. |
The visual support offered will be appropriate to the duration of the surgery, i.e. more than 1 hour." conditions: General Surgery conditions: Orthopedic Procedures studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: orthopaedic surgery name: orthopaedi... |
<|newrecord|> nctId: NCT06333626 id: 2020281 briefTitle: Effects of an Oral Multi-vitamin Carbohydrate Beverage on Intraoperative Nausea and Vomiting overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-03-31 date: 2025-03-31 date: 2024-03-27 date: 2024-03-27 name: The First Affiliated Hospital of Soochow Univ... |
<|newrecord|> nctId: NCT06333613 id: CR-6565 briefTitle: Evaluation of Acuvue Oasys 1-Day Contact Lenses in New Wearers overallStatus: RECRUITING date: 2024-03-26 date: 2024-05-20 date: 2024-05-20 date: 2024-03-27 date: 2024-04-24 name: Johnson & Johnson Vision Care, Inc. class: INDUSTRY briefSummary: This is a multi-s... |
<|newrecord|> nctId: NCT06333600 id: Soh-Med-23-07-05 briefTitle: Efficacy and Safety of Topical Vitamin D Analogue in Treatment of Female Pattern Hair Loss overallStatus: RECRUITING date: 2023-05-20 date: 2024-04-01 date: 2024-05-01 date: 2024-03-27 date: 2024-03-27 name: Sohag University class: OTHER briefSummary: Th... |
<|newrecord|> nctId: NCT06333587 id: IEO 1810 briefTitle: Minimally Invasive Treatments of the Thyroid acronym: MIPA-MITT overallStatus: RECRUITING date: 2022-10-10 date: 2025-12-31 date: 2035-12-31 date: 2024-03-27 date: 2024-03-27 name: European Institute of Oncology class: OTHER briefSummary: This is a prospective c... |
<|newrecord|> nctId: NCT06333574 id: CDUTCM20240313 briefTitle: Weight Management of Dialysis Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-27 date: 2024-03-27 name: qinxiu zhang class: OTHER briefSummary: The goal of this clinical trial is to Improve the qu... |
* \[Improve the self-compliance of dialysis patients with weight management\] |
* \[alleviate the volume load of dialysis patients and reduce cardiovascular complications\] Participants will be divided into two groups based on a weight management regimen： Control group: received routine outpatient management. Specific methods: The dialysis doctor registered the information of the patient\'s we... |
Intervention group: On the basis of routine outpatient management, patients or their family members were subjected to remote follow-up management based on wechat, and the follow-up time was 6 months. Specific methods: Same as the control group, the information of weight and blood pressure of the patients was registered... |
<|newrecord|> nctId: NCT06333561 id: Liver Project 7 briefTitle: HAIC Combined With Lenvatinib and PD-1 Inhibitor in Infiltrative Hepatocellular Carcinoma overallStatus: RECRUITING date: 2021-01-01 date: 2024-12-30 date: 2024-12-30 date: 2024-03-27 date: 2024-03-27 name: Sun Yat-sen University class: OTHER briefSummary... |
<|newrecord|> nctId: NCT06333548 id: KSH_MB_2024_1 briefTitle: Cord Blood Alarin Levels in Term Babies overallStatus: COMPLETED date: 2023-09-18 date: 2023-12-23 date: 2024-01-15 date: 2024-03-27 date: 2024-03-29 name: Konya City Hospital class: OTHER briefSummary: In this study, alarin levels in the cord blood of babi... |
<|newrecord|> nctId: NCT06333535 id: 2022/568 briefTitle: Foot and Abdominal Massage Applied to After Colonoscopy overallStatus: COMPLETED date: 2023-06-01 date: 2024-01-01 date: 2024-02-25 date: 2024-03-27 date: 2024-03-27 name: TC Erciyes University class: OTHER briefSummary: The aim of this study was to determine th... |
<|newrecord|> nctId: NCT06333522 id: 23-00979 briefTitle: Losartan Use to Mitigate Arthrofibrosis Following Total Joint Arthroplasty overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2026-01-01 date: 2026-01-01 date: 2024-03-27 date: 2024-03-27 name: NYU Langone Health class: OTHER briefSummary: The purpose of t... |
<|newrecord|> nctId: NCT06333509 id: CT071-HM-01 briefTitle: Anti-GPRC5D CAR-T Cells (CT071) in Participants With RRMM or RRpPCL overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-06-15 date: 2027-12-31 date: 2024-03-27 date: 2024-03-27 name: CARsgen Therapeutics Co., Ltd. class: INDUSTRY briefSummary: A Pha... |
<|newrecord|> nctId: NCT06333496 id: AB20240102H briefTitle: Effect of a Glucagon Like Peptide 1 (GLP1) Booster in Healthy Humans overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-02 date: 2024-03-29 date: 2024-04-08 date: 2024-03-27 date: 2024-04-15 name: Alpine Biotech LLC class: INDUSTRY briefSummary: BACKGROUND GL... |
PURPOSE The purpose of this study is to assess several clinical endpoints and questionnaires in healthy volunteers taking the new GB formula. |
SCOPE The scope of this protocol covers the non-clinical portion as well as the assessment of several clinical endpoints and questionnaires. In brief, the non-clinical design will be an open-label study involving volunteers taking GB everyday for 12 weeks. Data analysis will involve measuring the clinical endpoints acr... |
<|newrecord|> nctId: NCT06333483 id: AUTO1-SL1 id: 2023-508236-60-00 type: CTIS briefTitle: A Study of CD19 Targeted CAR T Cell Therapy in Patients With Severe, Refractory Systemic Lupus Erythematosus (SLE) acronym: CARLYSE overallStatus: RECRUITING date: 2024-02-02 date: 2024-11 date: 2025-10 date: 2024-03-27 date: 20... |
<|newrecord|> nctId: NCT06333470 id: 2024KYPJ025 briefTitle: Liwan Eye Study: the Fourth Follow-up overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-09-30 date: 2024-09-30 date: 2024-03-27 date: 2024-03-28 name: Zhongshan Ophthalmic Center, Sun Yat-sen University class: OTHER briefSummary: Primary angle-clo... |
<|newrecord|> nctId: NCT06333457 id: EA4/024/24 briefTitle: Presence and Relapse Rates in Patients With Alcohol Use Disorder Using Virtual Reality acronym: PRE-VR overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-11-01 date: 2025-02-01 date: 2024-03-27 date: 2024-03-27 name: Charite University, Berlin, Germ... |
Study group: abstinent patients (at least 18 years old) with a diagnosed alcohol dependence after completed inpatient withdrawal treatment in the the last 3 months. |
Primary hypothesis: the experience of presence during a virtual presentation of alcohol in alcohol-dependent patients is associated with levels of craving for alcohol during VR-CET. conditions: Alcohol Dependence studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 100 type: ESTIMA... |
<|newrecord|> nctId: NCT06333444 id: n. 08, 09/03/2021 briefTitle: Counselling Intervention for College Students Experienced Psychological Distress acronym: TRESPASS overallStatus: RECRUITING date: 2022-01-01 date: 2024-12-31 date: 2025-12-31 date: 2024-03-27 date: 2024-03-27 name: University of Campania "Luigi Vanvite... |
The main question it aims to answer are: |
* is the psychological counselling intervention useful in improving psychological distress and academic motivation |
* which psychological variables predict the intervention outcome conditions: University Students conditions: Psychological Intervention conditions: Psychological Distress studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Four weekly psychological counselli... |
<|newrecord|> nctId: NCT06333431 id: WN/WF briefTitle: Effects of WN and WF During Gastroscopy acronym: WF/WN_GCPY overallStatus: NOT_YET_RECRUITING date: 2024-04-03 date: 2024-05-30 date: 2024-06-08 date: 2024-03-27 date: 2024-03-27 name: Suleyman Demirel University class: OTHER briefSummary: Background: Gastroscopy i... |
Purpose: To examine effects of glass waterfall and white noise on pain, anxiety and physiological parameters during gastroscopy Method: The population of the study consists of all patients who applied to Mardin Education and Research Hospital, Department of General Surgery, Endoscopy Unit and were scheduled for gastros... |
<|newrecord|> nctId: NCT06333418 id: VR/WF briefTitle: Effects of VR and Glass WF Colonoscopy acronym: VR/WN_colon overallStatus: NOT_YET_RECRUITING date: 2024-04-03 date: 2024-05-30 date: 2024-06-08 date: 2024-03-27 date: 2024-03-27 name: Suleyman Demirel University class: OTHER briefSummary: Background: Today, colono... |
Purpose: To examine the effect of virtual rain forest and glass waterfall on satisfaction, comfort, anxiety, and vital signs before colonoscopy Method: The population of the study consists of all patients who applied to Mardin Education and Research Hospital, Department of General Surgery, Endoscopy Unit and were sched... |
<|newrecord|> nctId: NCT06333405 id: FMTNEC/01/2024 briefTitle: Fecal Microbiota Transplantation (FMT) as a Prophylaxis of Necrotizing Enterocolitis (NEC) - Clinical Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-01-31 date: 2025-01-31 date: 2024-03-27 date: 2024-03-27 name: Medical University of W... |
This is the first stage of a clinical trial testing the effectiveness of FMT in NEC, the aim of which is to examine the safety profile and analyze all side effects. conditions: Necrotizing Enterocolitis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: sin... |
<|newrecord|> nctId: NCT06333392 id: TotalUnderwater_REK577567 briefTitle: Total Underwater Colonoscopy (TUC) for Improved Colorectal Cancer Screening: A Randomized Controlled Trial overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-05 date: 2026-12 date: 2024-03-27 date: 2024-03-27 name: Vestre Viken Hospital ... |
1. SSLs will be more visible as they "float" on the submucosa and contract into the lumen, while full distension by gas stretches the mucosa, making detection of flat lesions more difficult. |
2. Water works like a magnifying lens, making detection and detailed characterisation of lesions easier. |
3. uEMR is eased. |
4. Improved bowel cleansing |
The goal of this clinical trial is to compare colonoscopy outcomes for standard gas (CO2) insufflation and TUC during withdrawal in patients participating in colonoscopy in the Norwegian and Swedish colorectal cancer screening programme after a positive fecal immunochemical test. |
The overarching research questions of the present trial is whether colonoscopy outcomes are improved when CO2 insufflation is replaced by TUC during withdrawal and whether the new technique reduces the ecological footprint of the colonoscopy examination. |
The project has five main hypotheses: |
1. TUC is superior to the standard approach (CO2 withdrawal) regarding detection of proximal SSLs. |
2. TUC increases the rate of complete resection of lesions \>= 10mm. |
3. TUC reduces the rate of painful colonoscopies and vasovagal reactions. |
4. TUC reduces the health care costs by reduced use of single use accessories and reduced number of redundant colonoscopies to obtain polypfree colon. |
5. TUC reduces the carbon footprint by reduced use of single use accessories. |
If TUC is superior to gas insufflation, the technique may be implemented rapidly since the technique is easy to learn. This study will increase endoscopy competence at participating centres. The centres are involved in national colonoscopy training programs, so the technique will quickly be passed on to other hospitals... |
The trial can be linked to three of the Global Goals: |
* Good health and well-being: The increased detection and improved complete removal of sessile serrated lesions can subsequently decrease the risk of CRC and CRC mortality during follow-up. TUC will probably reduce the rate of painful procedures and vasovagal reactions and thus increase the acceptance of a screening pr... |
* Gender equality: Women have a similar lifetime risk for CRC as men but less benefit of screening regardless of whether they are screened by sigmoidoscopy, FIT or colonoscopy. The reason is probably missed sessile serrated lesions in the proximal colon. If TUC improves SSLDR and complete lesion resection, this may lea... |
* Responsible consumption and production: The TUC technique will also reduce the ecological footprint of colonoscopy activity due to reduced consumption of single use accessories and reduced number of colonoscopies to achieve polyp free colon. Furthermore, the cost for the health care system will be substantially reduc... |
<|newrecord|> nctId: NCT06333379 id: SichuanPPHLC04 id: 2020LY01 type: OTHER_GRANT domain: Sichuan Provincial People's Hospital briefTitle: Aspergillosis Detection Via EBC-GM in Ventilated Patients overallStatus: COMPLETED date: 2023-01-02 date: 2023-12-30 date: 2024-01-10 date: 2024-03-27 date: 2024-03-27 name: Lin Ch... |
Objective: To evaluate the diagnostic accuracy of measuring GM levels in EBC for detecting IPA in mechanically ventilated patients, comparing it against the conventional Bronchoalveolar Lavage Fluid (BALF)-GM measurements. |
Methods: A clinical trial will be conducted with 75 mechanically ventilated patients suspected of having IPA. The study will compare the effectiveness of EBC-GM levels against BALF-GM levels in diagnosing IPA, focusing on sensitivity, specificity, and diagnostic accuracy. The novel, self-designed EBC collection device ... |
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